2FDB

crystal structure of fibroblast growth factor (fgf)8b in complex with fgf receptor (fgfr) 2c

• Total interactions analyzed: 6
• Total true interactions: 6
• Strongest Interaction:
  • Chains: M-P
  • Int. Res.: 151
  • Norm. En. per Res.: -5.1844
• Hub Node: M(3)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
M-P	-131.0739	-96.8377	-554.939	-782.8505	151	37	8	22268	5	61	72
M-N	0.0	0.0	-0.2014	-0.2014	6	0	0	62	0	2	9
M-R	0.0	-6.6135	-26.1866	-32.8001	20	0	0	1192	0	3	3
P-N	0.0	-6.6249	-26.6706	-33.2955	20	0	0	1194	0	3	3
P-R	-87.1746	23.8405	-214.169	-277.5032	115	19	4	9083	2	24	29
N-R	-87.2959	-60.2953	-516.699	-664.2901	142	35	8	20531	4	51	58

Interface residues

• M-P: ALA140M, ALA2168P, ALA2171P, ALA2172P, ALA2284P, ALA2314P, ALA2315P, ALA2344P, ALA77M, ARG155M, ARG170M, ARG177M, ARG180M, ARG2165P, ARG2251P, ARG2253P, ARG37M, ARG48M, ARG49M, ARG52M, ARG59M, ARG96M, ARG98M, ASN136M, ASN137M, ASN2158P, ASN2173P, ASN2318P, ASN2346P, ASP2247P, ASP2283P, ASP2321P, ASP44M, ASP79M, ASP91M, CYS2278P, CYS2342P, GLN167M, GLN2285P, GLN2289P, GLN34M, GLN39M, GLN45M, GLN55M, GLU131M, GLU135M, GLU2160P, GLU2163P, GLU2250P, GLU2323P, GLU2325P, GLU2339P, GLU78M, GLU89M, GLY2316P, GLY2345P, GLY2349P, GLY62M, GLY80M, GLY94M, HIS173M, HIS2167P, HIS2245P, HIS2254P, HIS2287P, HIS2293P, HIS2353P, HIS35M, HIS64M, ILE132M, ILE2288P, ILE2291P, ILE2324P, ILE2348P, ILE2350P, ILE51M, ILE87M, LEU134M, LEU141M, LEU178M, LEU2166P, LEU2246P, LEU2309P, LEU2312P, LEU2343P, LEU46M, LEU50M, LYS156M, LYS176M, LYS2161P, LYS2164P, LYS2226P, LYS2310P, LYS2313P, LYS2322P, LYS63M, MET175M, MET2162P, PHE129M, PHE174M, PHE2352P, PHE32M, PHE93M, PRO179M, PRO2170P, PRO2256P, PRO2286P, SER2252P, SER2282P, SER2347P, SER2351P, SER2354P, SER40M, SER47M, SER58M, SER61M, SER95M, THR130M, THR139M, THR2159P, THR2174P, THR2319P, THR2320P, THR2341P, THR33M, THR43M, THR53M, THR60M, THR90M, THR92M, TRP2290P, TYR138M, TYR2244P, TYR2281P, TYR2340P, TYR54M, TYR57M, VAL133M, VAL2169P, VAL2175P, VAL2248P, VAL2249P, VAL2280P, VAL2311P, VAL2317P, VAL2326P, VAL36M, VAL42M, VAL88M, VAL97M, VAL99M
• M-N: ARG1170N, ARG170M, HIS1168N, HIS168M, THR1033N, THR33M
• M-R: ARG170M, ARG3253R, ARG3255R, ARG59M, ASN136M, ASN137M, ASN3346R, GLU135M, GLY3349R, HIS3254R, ILE3257R, ILE3348R, ILE3350R, LEU134M, PHE3352R, PRO3256R, SER3347R, SER3351R, TYR138M, VAL133M
• P-N: ARG1059N, ARG1170N, ARG2253P, ARG2255P, ASN1136N, ASN1137N, ASN2346P, GLU1135N, GLY2349P, HIS2254P, ILE2257P, ILE2348P, ILE2350P, LEU1134N, PHE2352P, PRO2256P, SER2347P, SER2351P, TYR1138N, VAL1133N
• P-R: ALA2171P, ALA2172P, ALA2260P, ALA2264P, ALA2355P, ALA3171R, ALA3172R, ALA3260R, ALA3264R, ALA3355R, ARG2203P, ARG2210P, ARG2251P, ARG2253P, ARG2255P, ARG3203R, ARG3210R, ARG3251R, ARG3253R, ARG3255R, ASN2173P, ASN2211P, ASN2265P, ASN3173R, ASN3265R, ASN3346R, ASP2225P, ASP2283P, ASP3225R, ASP3283R, GLN2200P, GLN2212P, GLN2259P, GLN3200R, GLN3212R, GLN3259R, GLU2219P, GLU2339P, GLU3219R, GLU3250R, GLU3339R, GLY2205P, GLY2206P, GLY2261P, GLY2349P, GLY3205R, GLY3206R, GLY3261R, GLY3349R, HIS2213P, HIS2254P, HIS2353P, HIS3213R, HIS3254R, HIS3353R, ILE2204P, ILE2217P, ILE2257P, ILE2348P, ILE3204R, ILE3217R, ILE3257R, ILE3348R, LEU2258P, LEU2262P, LEU3258R, LEU3262R, LYS2208P, LYS3208R, MET2218P, MET3218R, PHE2276P, PHE2352P, PHE3276R, PHE3352R, PRO2170P, PRO2256P, PRO2263P, PRO3170R, PRO3256R, PRO3263R, SER2215P, SER2220P, SER2252P, SER2347P, SER2351P, SER2354P, SER3220R, SER3252R, SER3347R, SER3351R, SER3354R, THR2174P, THR2341P, THR3174R, THR3341R, TRP2356P, TRP3356R, TYR2207P, TYR2281P, TYR2340P, TYR3207R, TYR3340R, VAL2169P, VAL2175P, VAL2209P, VAL2221P, VAL2222P, VAL2277P, VAL3169R, VAL3175R, VAL3209R, VAL3221R, VAL3222R, VAL3277R
• N-R: ALA1077N, ALA1140N, ALA3168R, ALA3171R, ALA3172R, ALA3284R, ALA3314R, ALA3315R, ALA3344R, ARG1037N, ARG1048N, ARG1049N, ARG1052N, ARG1059N, ARG1096N, ARG1098N, ARG1155N, ARG1170N, ARG1177N, ARG3165R, ARG3251R, ARG3253R, ARG3255R, ASN1136N, ASN1137N, ASN3173R, ASN3346R, ASP1044N, ASP1079N, ASP1091N, ASP3247R, ASP3283R, CYS3342R, GLN1034N, GLN1039N, GLN1045N, GLN1055N, GLN1142N, GLN1167N, GLN3285R, GLN3289R, GLU1078N, GLU1089N, GLU1131N, GLU1135N, GLU3160R, GLU3163R, GLU3250R, GLU3325R, GLU3339R, GLY1062N, GLY1080N, GLY1094N, GLY3316R, GLY3345R, GLY3349R, HIS1035N, HIS1064N, HIS1173N, HIS3167R, HIS3245R, HIS3254R, HIS3287R, HIS3293R, HIS3353R, ILE1051N, ILE1087N, ILE1132N, ILE3288R, ILE3291R, ILE3324R, ILE3348R, ILE3350R, LEU1046N, LEU1050N, LEU1134N, LEU1141N, LEU1178N, LEU3166R, LEU3246R, LEU3309R, LEU3312R, LEU3327R, LEU3343R, LYS1063N, LYS1176N, LYS3164R, LYS3292R, LYS3310R, LYS3313R, MET1175N, MET3162R, PHE1032N, PHE1093N, PHE1129N, PHE1174N, PHE3177R, PHE3352R, PRO3170R, PRO3256R, PRO3286R, SER1040N, SER1047N, SER1058N, SER1061N, SER1095N, SER3252R, SER3282R, SER3347R, SER3351R, SER3354R, THR1033N, THR1043N, THR1053N, THR1060N, THR1090N, THR1092N, THR1130N, THR1139N, THR3174R, THR3341R, TRP3290R, TYR1054N, TYR1057N, TYR1138N, TYR3281R, TYR3328R, TYR3340R, VAL1036N, VAL1042N, VAL1088N, VAL1097N, VAL1099N, VAL1133N, VAL3169R, VAL3175R, VAL3248R, VAL3249R, VAL3280R, VAL3311R, VAL3317R, VAL3326R