2F8X

crystal structure of activated notch, csl and maml on hes-1 promoter dna sequence

• Total interactions analyzed: 10
• Total true interactions: 3
• Strongest Interaction:
  • Chains: K-M
  • Int. Res.: 72
  • Norm. En. per Res.: -3.4669
• Hub Node: C(2)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
C-K	-45.617	-22.0018	-225.781	-293.3997	125	12	0	10531	5	55	44
C-M	-42.7015	-56.3285	-229.795	-328.825	104	19	3	10335	9	41	23
K-M	-36.8249	-112.4103	-100.382	-249.6172	72	15	1	4635	7	37	22

Interface residues

• C-K: ALA1889K, ALA1937K, ALA1968K, ALA1969K, ALA1972K, ALA1974K, ALA2004K, ALA2007K, ALA2036K, ALA2037K, ALA2038K, ALA355C, ARG122C, ARG146C, ARG1927K, ARG1938K, ARG1941K, ARG1963K, ARG2005K, ARG2061K, ARG2071K, ARG2096K, ARG2105K, ARG382C, ASN2040K, ASN2041K, ASN2059K, ASN2060K, ASN349C, ASN363C, ASN93C, ASP120C, ASP1973K, ASP1995K, ASP2026K, ASP2092K, ASP2095K, ASP2100K, ASP353C, CYS1891K, CYS383C, GLN347C, GLN362C, GLN409C, GLU1930K, GLU2062K, GLU2063K, GLU2072K, GLU2104K, GLU344C, GLU358C, GLU385C, GLU433C, GLY350C, GLY351C, GLY352C, GLY361C, GLY384C, GLY92C, HIS124C, HIS1967K, HIS1994K, HIS2093K, HIS2107K, ILE147C, ILE1888K, ILE2001K, LEU143C, LEU1935K, LEU2002K, LEU2006K, LEU2028K, LEU2068K, LEU346C, LEU348C, LEU357C, LEU359C, LEU388C, LYS121C, LYS123C, LYS145C, LYS148C, LYS2030K, MET126C, MET1887K, MET1961K, MET1993K, MET2094K, MET356C, MET387C, PHE125C, PHE364C, PHE428C, PRO339C, PRO366C, PRO407C, PRO432C, PRO434C, SER1890K, SER1892K, SER1940K, SER1971K, SER2074K, SER345C, SER386C, THR1884K, THR1925K, THR1928K, THR1997K, THR2091K, THR360C, THR365C, THR427C, THR429C, THR431C, TRP2035K, TYR1939K, TYR381C, TYR430C, VAL1970K, VAL2008K, VAL2039K, VAL342C, VAL354C, VAL408C
• C-M: ALA335C, ALA355C, ALA39M, ALA58M, ALA66M, ALA87C, ARG11C, ARG16C, ARG26M, ARG31M, ARG32M, ARG369C, ARG382C, ARG40M, ARG416C, ARG48M, ARG53M, ARG62M, ARG70M, ASN102C, ASN135C, ASN349C, ASN363C, ASN367C, ASN417C, ASP137C, ASP138C, ASP353C, CYS30M, CYS37M, CYS383C, CYS63M, CYS86C, GLN100C, GLN54M, GLN61M, GLN81C, GLN84C, GLN96C, GLN99C, GLU104C, GLU28M, GLU378C, GLU38M, GLU42M, GLU52M, GLU82C, GLU97C, GLY134C, GLY140C, GLY350C, GLY384C, GLY90C, HIS33M, HIS34M, HIS55M, HIS60M, ILE139C, ILE27M, ILE64M, ILE89C, LEU101C, LEU23M, LEU29M, LEU334C, LEU368C, LEU388C, LEU49M, LEU51M, LEU59M, LYS130C, LYS67M, MET131C, MET20M, MET356C, MET380C, MET387C, MET98C, PHE132C, PHE364C, PHE57M, PHE88C, PRO336C, PRO339C, PRO366C, PRO46M, SER128C, SER136C, SER35M, SER386C, SER45M, THR338C, THR365C, THR36M, THR379C, THR56M, TYR133C, TYR381C, TYR41M, VAL141C, VAL19M, VAL333C, VAL354C, VAL390C
• K-M: ALA1972K, ALA1974K, ALA2007K, ALA2037K, ALA2038K, ALA2069K, ALA2070K, ALA2078K, ALA2102K, ARG1941K, ARG2005K, ARG2071K, ARG2105K, ARG2112K, ARG22M, ARG25M, ARG26M, ARG40M, ARG48M, ASN2040K, ASN2041K, ASP1973K, ASP2014K, ASP2043K, ASP2109K, CYS30M, CYS37M, GLN1975K, GLN1979K, GLN2103K, GLU2009K, GLU2072K, GLU2076K, GLU2104K, GLU21M, GLU47M, GLU50M, GLU52M, GLY1976K, GLY2010K, GLY2073K, HIS16M, HIS2107K, HIS2108K, HIS33M, ILE2110K, ILE27M, LEU2006K, LEU2113K, LEU23M, LEU29M, LEU49M, LEU51M, MET2011K, MET2106K, PHE1978K, PRO46M, SER1940K, SER1971K, SER2074K, SER45M, THR2077K, THR36M, TYR2075K, TYR41M, VAL1970K, VAL19M, VAL2008K, VAL2039K, VAL2042K, VAL2111K, VAL44M