2F66

structure of the escrt-i endosomal trafficking complex

• Total interactions analyzed: 15
• Total true interactions: 9
• Strongest Interaction:
  • Chains: A-C
  • Int. Res.: 76
  • Norm. En. per Res.: -4.8447
• Hub Node: A(3)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-36.0259	-50.0597	-356.536	-442.6216	115	21	11	14799	2	36	29
A-C	-37.8022	-104.2396	-226.155	-368.1968	76	13	6	9497	4	18	16
A-E	-9.0856	-2.5055	-190.9	-202.4911	76	1	11	7744	0	8	11
B-D	-16.1278	-2.3772	-190.852	-209.3571	75	12	10	7887	0	6	12
B-E	-16.6862	-35.6933	-167.833	-220.2125	110	4	5	7235	6	34	26
B-F	0.0	-2.6431	-27.5799	-30.223	21	0	0	1504	0	4	5
C-E	0.0	0.0	-22.5171	-22.5171	20	0	0	1328	0	4	2
D-E	-65.6406	-45.0829	-357.249	-467.9724	118	20	13	14558	2	37	28
D-F	-32.9207	-78.5263	-196.479	-307.9259	80	12	6	9444	4	20	18

Interface residues

• A-B: ALA344A, ALA367A, ALA56B, ARG347A, ARG351A, ARG364A, ARG368A, ARG374A, ARG379A, ASN27B, ASN326A, ASN69B, ASP20B, ASP26B, ASP323A, ASP335A, ASP33B, ASP357A, ASP51B, ASP60B, ASP63B, GLN16B, GLN327A, GLN362A, GLN369A, GLN370A, GLN66B, GLN77B, GLU21B, GLU343A, GLU365A, GLU38B, GLU42B, GLU54B, GLY324A, GLY352A, GLY363A, HIS125B, HIS19B, HIS350A, HIS376A, HIS52B, HIS93B, ILE29B, ILE342A, ILE354A, ILE377A, ILE37B, ILE380A, ILE43B, ILE46B, ILE48B, ILE62B, ILE97B, LEU17B, LEU24B, LEU325A, LEU328A, LEU331A, LEU338A, LEU345A, LEU349A, LEU356A, LEU366A, LEU372A, LEU384A, LEU40B, LEU50B, LEU74B, LYS34B, LYS361A, LYS55B, LYS59B, LYS73B, MET321A, MET348A, PHE18B, PHE25B, PHE359A, PHE371A, PHE78B, PRO23B, PRO355A, PRO383A, SER15B, SER28B, SER346A, SER382A, SER385A, SER41B, SER45B, SER61B, THR30B, THR322A, THR339A, THR381A, THR39B, THR49B, THR65B, THR68B, THR70B, TRP375A, TYR329A, TYR44B, TYR57B, TYR67B, TYR81B, VAL22B, VAL360A, VAL36B, VAL373A, VAL47B, VAL53B, VAL71B, VAL80B
• A-C: ALA178C, ALA203C, ALA333A, ALA337A, ALA344A, ARG173C, ARG192C, ARG198C, ARG199C, ARG347A, ARG351A, ASN187C, ASN326A, ASN330A, ASP176C, ASP180C, ASP182C, ASP190C, ASP335A, ASP340A, GLN194C, GLN327A, GLN334A, GLN362A, GLN369A, GLN370A, GLU169C, GLU200C, GLU343A, GLU365A, GLY352A, GLY363A, HIS196C, ILE175C, ILE185C, ILE191C, ILE342A, ILE354A, LEU181C, LEU189C, LEU197C, LEU202C, LEU325A, LEU328A, LEU331A, LEU338A, LEU345A, LEU366A, LYS186C, LYS201C, LYS361A, MET321A, MET348A, PHE184C, PHE359A, PRO355A, SER165C, SER166C, SER174C, SER177C, SER346A, THR170C, THR172C, THR193C, THR204C, THR339A, THR341A, THR353A, THR358A, TRP205C, TYR188C, TYR195C, TYR329A, TYR336A, VAL332A, VAL373A
• A-E: ALA101E, ALA108E, ALA111E, ALA333A, ALA337A, ALA367A, ALA99E, ARG114E, ARG117E, ARG374A, ARG379A, ASN105E, ASN110E, ASN326A, ASN330A, ASN83E, ASN91E, ASP102E, ASP335A, ASP340A, GLN327A, GLN334A, GLN370A, GLN378A, GLN95E, GLU116E, GLU343A, GLU88E, GLU98E, GLY118E, GLY324A, HIS376A, HIS93E, ILE106E, ILE112E, ILE119E, ILE121E, ILE342A, ILE377A, ILE380A, ILE90E, ILE97E, LEU115E, LEU325A, LEU328A, LEU331A, LEU372A, LEU384A, LEU82E, LYS79E, LYS87E, LYS92E, MET321A, PHE100E, PHE371A, PHE78E, PHE94E, PRO120E, PRO383A, SER109E, SER382A, SER385A, SER84E, SER96E, THR103E, THR107E, THR113E, THR339A, THR381A, TRP375A, TYR104E, TYR329A, TYR336A, TYR81E, VAL332A, VAL373A
• B-D: ALA101B, ALA108B, ALA111B, ALA333D, ALA337D, ALA99B, ARG114B, ARG117B, ARG374D, ARG379D, ASN105B, ASN110B, ASN326D, ASN330D, ASN83B, ASN91B, ASP102B, ASP335D, ASP340D, GLN327D, GLN334D, GLN370D, GLN378D, GLN95B, GLU116B, GLU343D, GLU88B, GLU89B, GLU98B, GLY118B, HIS376D, HIS93B, ILE106B, ILE112B, ILE119B, ILE121B, ILE342D, ILE377D, ILE380D, ILE90B, ILE97B, LEU115B, LEU325D, LEU328D, LEU331D, LEU372D, LEU384D, LEU82B, LYS79B, LYS87B, LYS92B, MET321D, PHE100B, PHE371D, PHE78B, PHE94B, PRO120B, PRO383D, SER109B, SER382D, SER385D, SER84B, SER96B, THR103B, THR107B, THR113B, THR339D, THR381D, TRP375D, TYR104B, TYR329D, TYR336D, TYR81B, VAL332D, VAL373D
• B-E: ALA101B, ALA101E, ALA123B, ALA123E, ALA99B, ALA99E, ARG114B, ARG117B, ARG117E, ASN105B, ASN105E, ASN91B, ASN91E, ASP102B, ASP102E, ASP26B, ASP33B, ASP33E, ASP51B, ASP51E, GLN95B, GLN95E, GLU116B, GLU116E, GLU124B, GLU124E, GLU42B, GLU42E, GLU88B, GLU88E, GLU89B, GLU89E, GLU98B, GLU98E, GLY118B, GLY118E, HIS125B, HIS125E, HIS52B, HIS52E, HIS93B, HIS93E, ILE112B, ILE112E, ILE121B, ILE121E, ILE29B, ILE29E, ILE37B, ILE37E, ILE43B, ILE43E, ILE46B, ILE46E, ILE48B, ILE48E, ILE90B, ILE90E, ILE97B, ILE97E, LEU115B, LEU115E, LEU17B, LEU17E, LEU40B, LEU40E, LEU82E, LYS32B, LYS32E, LYS34B, LYS34E, LYS79E, LYS92B, LYS92E, PHE100B, PHE100E, PHE18B, PHE18E, PHE78B, PHE78E, PHE94B, PHE94E, PRO120B, PRO120E, SER15B, SER15E, SER28B, SER28E, SER41B, SER41E, SER45B, SER45E, SER96B, SER96E, THR103B, THR103E, THR122B, THR122E, THR30B, THR30E, THR39B, THR39E, TYR104B, TYR104E, TYR44B, TYR44E, VAL36B, VAL36E, VAL47B, VAL47E
• B-F: ALA108B, ALA111B, ALA203F, ARG114B, ARG117B, ARG199F, ASN110B, GLU116B, GLU200F, HIS196F, ILE112B, LEU115B, LEU197F, LEU202F, LYS201F, LYS207F, SER109B, THR107B, THR113B, THR204F, TYR195F
• C-E: ALA108E, ALA111E, ALA203C, ARG117E, ARG198C, ARG199C, ASN110E, ASP206C, GLU116E, GLU200C, HIS196C, ILE112E, LEU197C, LEU202C, LYS201C, SER109E, THR107E, THR113E, THR204C, TYR195C
• D-E: ALA344D, ALA367D, ALA56E, ARG347D, ARG351D, ARG364D, ARG368D, ARG374D, ARG379D, ASN326D, ASN330D, ASN69E, ASP20E, ASP26E, ASP323D, ASP335D, ASP33E, ASP340D, ASP357D, ASP51E, ASP60E, ASP63E, GLN16E, GLN327D, GLN362D, GLN369D, GLN370D, GLN378D, GLN66E, GLN77E, GLU21E, GLU343D, GLU365D, GLU38E, GLU42E, GLU54E, GLY324D, GLY352D, GLY363D, HIS125E, HIS19E, HIS350D, HIS376D, HIS52E, HIS93E, ILE29E, ILE342D, ILE354D, ILE377D, ILE37E, ILE380D, ILE43E, ILE46E, ILE48E, ILE62E, ILE97E, LEU17E, LEU24E, LEU325D, LEU328D, LEU331D, LEU338D, LEU345D, LEU349D, LEU356D, LEU366D, LEU372D, LEU384D, LEU40E, LEU50E, LEU58E, LEU74E, LYS34E, LYS361D, LYS55E, LYS59E, LYS73E, MET321D, MET348D, PHE18E, PHE25E, PHE359D, PHE371D, PHE78E, PRO23E, PRO355D, PRO383D, SER15E, SER28E, SER346D, SER382D, SER385D, SER41E, SER45E, SER61E, THR30E, THR322D, THR339D, THR341D, THR381D, THR39E, THR49E, THR65E, THR68E, THR70E, TRP375D, TYR329D, TYR44E, TYR57E, TYR67E, TYR81E, VAL22E, VAL360D, VAL36E, VAL373D, VAL47E, VAL53E, VAL71E
• D-F: ALA178F, ALA203F, ALA333D, ALA337D, ALA344D, ARG173F, ARG192F, ARG198F, ARG199F, ARG347D, ARG351D, ASN187F, ASN326D, ASN330D, ASP162F, ASP176F, ASP180F, ASP182F, ASP190F, ASP335D, ASP340D, GLN167F, GLN194F, GLN327D, GLN334D, GLN362D, GLN369D, GLU169F, GLU200F, GLU343D, GLU365D, GLY352D, GLY363D, HIS196F, ILE175F, ILE185F, ILE191F, ILE342D, ILE354D, LEU168F, LEU181F, LEU189F, LEU197F, LEU202F, LEU325D, LEU328D, LEU331D, LEU338D, LEU345D, LEU366D, LYS186F, LYS201F, LYS207F, LYS361D, MET321D, MET348D, PHE184F, PHE359D, PRO355D, SER165F, SER166F, SER174F, SER177F, SER346D, THR170F, THR171F, THR172F, THR193F, THR204F, THR339D, THR341D, THR353D, THR358D, TRP205F, TYR188F, TYR195F, TYR329D, TYR336D, VAL332D, VAL373D