2EU1

crystal structure of the chaperonin groel-e461k

• Total interactions analyzed: 91
• Total true interactions: 39
• Strongest Interaction:
  • Chains: J-K
  • Int. Res.: 181
  • Norm. En. per Res.: -2.7018
• Hub Node: A(5)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-48.965	-25.3318	-334.469	-408.7658	179	9	9	15371	2	76	79
A-C	0.0	0.0	-0.1705	-0.1705	3	0	0	35	0	0	0
A-F	0.0	0.0	-0.1232	-0.1232	2	0	0	30	0	0	0
A-G	-64.1716	-32.0996	-366.618	-462.8892	186	17	9	16462	4	77	82
A-M	0.0	-8.0655	-31.7304	-39.7959	25	4	0	1274	2	12	19
B-C	-70.5958	-24.7161	-350.9	-446.2119	180	21	8	15688	4	78	84
B-D	0.0	0.0	-0.2205	-0.2205	3	0	0	39	0	0	0
B-G	0.0	0.0	-0.0739	-0.0739	2	0	0	22	0	0	0
B-L	0.0	0.6777	-28.871	-28.1933	24	2	0	1081	1	12	15
B-M	0.0	0.0	-0.026	-0.026	8	0	0	8	0	4	6
C-D	-71.3757	-36.4802	-352.44	-460.2958	181	19	9	15721	2	75	78
C-E	0.0	0.0	-0.2683	-0.2683	3	0	0	42	0	0	0
C-K	0.0	0.0	-16.9277	-16.9277	20	0	0	880	0	9	13
C-L	0.0	0.0	-0.0081	-0.0081	3	0	0	9	0	4	6
D-E	-81.2726	-29.6819	-388.813	-499.7675	185	30	12	16721	3	79	80
D-F	0.0	0.0	-0.3865	-0.3865	3	0	0	50	0	0	0
D-J	0.0	0.6512	-13.8161	-13.1649	19	1	0	808	0	9	13
D-K	0.0	0.0	-0.0003	-0.0003	2	0	0	1	0	3	3
E-F	-93.8339	-31.4361	-311.682	-436.9521	177	41	11	15764	3	78	79
E-G	0.0	0.0	-0.3129	-0.3129	3	0	0	42	0	0	0
E-I	-15.3684	0.1757	-22.421	-37.6137	18	8	0	932	0	11	12
E-J	0.0	0.0	-0.0355	-0.0355	7	0	0	10	0	4	6
F-G	-75.8122	-23.3458	-349.393	-448.5511	184	18	9	15669	2	76	78
F-H	0.0	-0.7621	-19.4136	-20.1757	25	10	0	1231	0	12	16
F-I	0.0	8.9193	-0.6147	8.3046	11	0	0	112	0	6	10
G-H	0.0	0.0	-1.0756	-1.0756	13	0	0	181	0	5	7
G-N	0.0	-12.7856			3
H-I	-63.9638	-23.0668	-323.15	-410.1806	177	15	9	14925	3	74	81
H-J	0.0	0.0	-0.0719	-0.0719	2	0	0	18	0	0	0
H-M	0.0	0.0	-0.0503	-0.0503	2	0	0	15	0	0	0
H-N	-23.1969	-49.5623			27
I-J	-58.1002	-29.8501	-329.069	-417.0193	179	14	6	15433	3	79	85
I-K	0.0	0.0	-0.1589	-0.1589	2	0	0	28	0	0	0
J-K	-83.3014	-32.229	-373.502	-489.0324	181	24	10	16368	3	82	85
J-L	0.0	0.0	-0.2278	-0.2278	3	0	0	34	0	0	0
K-L	-97.6488	-31.1411	-353.65	-482.4399	183	38	12	16429	5	80	84
K-M	0.0	0.0	-0.3217	-0.3217	3	0	0	43	0	0	0
L-M	-93.4258	-41.7498	-324.81	-459.9856	172	64	9	16178	3	78	79
M-N	-82.7081	-41.5934			31

Interface residues

• A-B: ALA12A, ALA239B, ALA241B, ALA243B, ALA24B, ALA258A, ALA26B, ALA278A, ALA2A, ALA383B, ALA384B, ALA3A, ALA46B, ALA481B, ALA57B, ALA71A, ARG118A, ARG13A, ARG18B, ARG197A, ARG231A, ARG268B, ARG284A, ARG285A, ARG36B, ARG58B, ASN112A, ASN206B, ASN21B, ASN229A, ASN265B, ASN37B, ASN433A, ASN457B, ASN68A, ASN68B, ASP115A, ASP179B, ASP253A, ASP25B, ASP283A, ASP361A, ASP41B, ASP523A, ASP5A, ASP64B, CYS458B, CYS519A, GLN184B, GLN432A, GLN436A, GLN453B, GLN72A, GLN72B, GLU186B, GLU214B, GLU216B, GLU232A, GLU238B, GLU252A, GLU255A, GLU257A, GLU303A, GLU308A, GLU310A, GLU386B, GLU388B, GLU460B, GLU483B, GLU518A, GLU59B, GLU61A, GLU61B, GLU63B, GLU76A, GLY180B, GLY182B, GLY244B, GLY256A, GLY269B, GLY280A, GLY282A, GLY32B, GLY35B, GLY382B, GLY459B, GLY45B, GLY512A, GLY70A, GLY9A, ILE227A, ILE230A, ILE270B, ILE49B, ILE515A, ILE60B, LEU183B, LEU237B, LEU23B, LEU40B, LEU456B, LEU513A, LEU524A, LEU62B, LYS117A, LYS207B, LYS225A, LYS226A, LYS242B, LYS245B, LYS272B, LYS277A, LYS286A, LYS28B, LYS34B, LYS364A, LYS390B, LYS42B, LYS4A, LYS51B, LYS65A, LYS65B, LYS75A, LYS75B, LYS7A, LYS80A, MET111A, MET114A, MET16A, MET267B, MET389B, MET514A, MET520A, MET69A, MET73A, PHE281A, PHE44B, PHE66A, PHE8A, PRO113A, PRO246B, PRO279A, PRO33B, PRO47B, SER217B, SER228A, SER358A, SER43B, SER509A, SER55B, THR181B, THR266B, THR30B, THR385B, THR482B, THR48B, THR50B, THR516A, THR517A, THR522A, TYR203A, TYR360A, VAL107A, VAL22B, VAL240B, VAL271B, VAL27B, VAL29B, VAL381B, VAL387B, VAL38B, VAL39B, VAL455B, VAL510A, VAL521A, VAL56B, VAL6A, VAL74A, VAL77A
• A-C: ALA2A, ALA3A, PHE44C
• A-F: ALA2F, PHE44A
• A-G: ALA12G, ALA239A, ALA241A, ALA243A, ALA24A, ALA258G, ALA26A, ALA278G, ALA2G, ALA383A, ALA384A, ALA3G, ALA46A, ALA481A, ALA57A, ALA71G, ARG118G, ARG13G, ARG18A, ARG197G, ARG231G, ARG268A, ARG284G, ARG285G, ARG322A, ARG36A, ARG58A, ASN112G, ASN206A, ASN21A, ASN229G, ASN265A, ASN37A, ASN433G, ASN457A, ASN68A, ASN68G, ASP115G, ASP179A, ASP253G, ASP25A, ASP283G, ASP359G, ASP361G, ASP41A, ASP435G, ASP523G, ASP5G, ASP64A, CYS458A, CYS519G, GLN184A, GLN432G, GLN436G, GLN453A, GLN72A, GLN72G, GLU186A, GLU214A, GLU216A, GLU232G, GLU238A, GLU252G, GLU255G, GLU257G, GLU303G, GLU308G, GLU310G, GLU386A, GLU388A, GLU460A, GLU483A, GLU518G, GLU59A, GLU61A, GLU61G, GLU63A, GLU76G, GLY180A, GLY182A, GLY244A, GLY256G, GLY269A, GLY280G, GLY282G, GLY32A, GLY35A, GLY382A, GLY459A, GLY45A, GLY512G, GLY70G, GLY9G, ILE227G, ILE230G, ILE270A, ILE49A, ILE515G, ILE60A, LEU116G, LEU183A, LEU237A, LEU23A, LEU40A, LEU456A, LEU513G, LEU524G, LEU62A, LYS117G, LYS207A, LYS225G, LYS226G, LYS242A, LYS245A, LYS272A, LYS277G, LYS286G, LYS28A, LYS34A, LYS364G, LYS380A, LYS390A, LYS42A, LYS4G, LYS51A, LYS65A, LYS65G, LYS75A, LYS75G, LYS7G, LYS80G, MET111G, MET114G, MET16G, MET267A, MET389A, MET514G, MET520G, MET69G, MET73G, PHE281G, PHE44A, PHE66G, PHE8G, PRO113G, PRO246A, PRO279G, PRO33A, PRO47A, SER217A, SER228G, SER358G, SER43A, SER509G, SER55A, SER79G, THR181A, THR266A, THR30A, THR357G, THR385A, THR482A, THR48A, THR50A, THR516G, THR517G, THR522G, TYR203G, TYR360G, VAL107G, VAL22A, VAL240A, VAL271A, VAL27A, VAL29A, VAL381A, VAL387A, VAL38A, VAL39A, VAL455A, VAL510G, VAL521G, VAL56A, VAL6G, VAL74G, VAL77G
• A-M: ALA312A, ALA312M, ASP316A, ASP316M, GLU308A, GLU308M, GLU310A, GLU310M, GLU315A, GLU315M, GLY306A, GLY306M, ILE305A, ILE305M, LEU314A, LEU314M, LYS311A, LYS311M, MET307A, MET307M, THR299A, THR299M, THR313A, THR313M, VAL236A
• B-C: ALA12B, ALA239C, ALA241C, ALA243C, ALA24C, ALA258B, ALA26C, ALA278B, ALA2B, ALA383C, ALA384C, ALA3B, ALA46C, ALA481C, ALA57C, ALA71B, ARG118B, ARG13B, ARG18C, ARG197B, ARG231B, ARG268C, ARG284B, ARG285B, ARG322C, ARG36C, ARG58C, ASN112B, ASN206C, ASN21C, ASN229B, ASN265C, ASN37C, ASN433B, ASN457C, ASN68B, ASN68C, ASP115B, ASP179C, ASP253B, ASP25C, ASP283B, ASP361B, ASP41C, ASP435B, ASP523B, ASP5B, ASP64C, CYS458C, CYS519B, GLN184C, GLN432B, GLN436B, GLN453C, GLN72B, GLN72C, GLU186C, GLU214C, GLU216C, GLU232B, GLU238C, GLU252B, GLU255B, GLU257B, GLU303B, GLU308B, GLU310B, GLU386C, GLU388C, GLU460C, GLU483C, GLU518B, GLU59C, GLU61B, GLU61C, GLU63C, GLU76B, GLY180C, GLY182C, GLY244C, GLY256B, GLY269C, GLY280B, GLY282B, GLY35C, GLY382C, GLY459C, GLY45C, GLY512B, GLY70B, GLY9B, ILE227B, ILE230B, ILE270C, ILE49C, ILE515B, ILE60C, LEU183C, LEU237C, LEU23C, LEU40C, LEU456C, LEU513B, LEU524B, LEU62C, LYS117B, LYS207C, LYS225B, LYS226B, LYS242C, LYS245C, LYS272C, LYS277B, LYS286B, LYS28C, LYS34C, LYS364B, LYS380C, LYS390C, LYS42C, LYS4B, LYS51C, LYS65B, LYS65C, LYS75B, LYS7B, LYS80B, MET111B, MET114B, MET16B, MET267C, MET389C, MET514B, MET520B, MET69B, MET73B, PHE281B, PHE44C, PHE66B, PHE8B, PRO113B, PRO246C, PRO279B, PRO33C, PRO47C, SER217C, SER228B, SER358B, SER43C, SER509B, SER55C, THR181C, THR266C, THR30C, THR357B, THR385C, THR482C, THR48C, THR50C, THR516B, THR517B, THR522B, TYR360B, VAL107B, VAL22C, VAL240C, VAL271C, VAL27C, VAL29C, VAL381C, VAL387C, VAL38C, VAL39C, VAL455C, VAL510B, VAL521B, VAL56C, VAL6B, VAL74B, VAL77B
• B-D: ALA2B, ALA3B, PHE44D
• B-G: ALA2G, PHE44B
• B-L: ALA312B, ALA312L, ASP316B, ASP316L, GLU308B, GLU308L, GLU310B, GLU310L, GLU315B, GLU315L, GLY306B, GLY306L, ILE305B, ILE305L, LEU314B, LEU314L, LYS311B, LYS311L, MET307B, MET307L, THR299B, THR299L, THR313B, THR313L
• B-M: ALA243M, GLU315B, GLU315M, GLU338B, GLU338M, LEU314B, LYS242M, THR313B
• C-D: ALA12C, ALA239D, ALA241D, ALA243D, ALA24D, ALA258C, ALA26D, ALA278C, ALA2C, ALA383D, ALA384D, ALA3C, ALA46D, ALA481D, ALA57D, ALA71C, ARG118C, ARG13C, ARG18D, ARG197C, ARG231C, ARG268D, ARG284C, ARG285C, ARG36D, ARG58D, ASN112C, ASN206D, ASN21D, ASN229C, ASN265D, ASN37D, ASN433C, ASN457D, ASN68C, ASN68D, ASP115C, ASP179D, ASP253C, ASP25D, ASP283C, ASP359C, ASP361C, ASP41D, ASP435C, ASP523C, ASP5C, ASP64D, CYS458D, CYS519C, GLN184D, GLN432C, GLN436C, GLN453D, GLN72C, GLN72D, GLU186D, GLU214D, GLU216D, GLU232C, GLU238D, GLU252C, GLU255C, GLU257C, GLU303C, GLU308C, GLU310C, GLU386D, GLU388D, GLU460D, GLU483D, GLU518C, GLU59D, GLU61C, GLU61D, GLU63D, GLU76C, GLY180D, GLY182D, GLY244D, GLY256C, GLY269D, GLY280C, GLY282C, GLY35D, GLY382D, GLY459D, GLY45D, GLY512C, GLY70C, GLY9C, ILE227C, ILE230C, ILE270D, ILE49D, ILE515C, ILE60D, LEU183D, LEU237D, LEU23D, LEU40D, LEU456D, LEU513C, LEU524C, LEU62D, LYS117C, LYS207D, LYS225C, LYS226C, LYS242D, LYS245D, LYS272D, LYS277C, LYS286C, LYS28D, LYS34D, LYS364C, LYS380D, LYS390D, LYS42D, LYS4C, LYS51D, LYS65C, LYS65D, LYS75C, LYS75D, LYS7C, LYS80C, MET111C, MET114C, MET16C, MET267D, MET389D, MET514C, MET520C, MET69C, MET73C, PHE281C, PHE44D, PHE66C, PHE8C, PRO113C, PRO246D, PRO279C, PRO33D, PRO47D, SER217D, SER228C, SER358C, SER43D, SER509C, SER55D, THR181D, THR266D, THR30D, THR357C, THR385D, THR482D, THR48D, THR50D, THR516C, THR517C, THR522C, TYR360C, VAL107C, VAL22D, VAL240D, VAL271D, VAL27D, VAL29D, VAL381D, VAL387D, VAL38D, VAL39D, VAL455D, VAL510C, VAL521C, VAL56D, VAL6C, VAL74C, VAL77C
• C-E: ALA2C, ALA3C, PHE44E
• C-K: ALA312C, ALA312K, ASP316C, ASP316K, GLU308C, GLU308K, GLU310C, GLU310K, GLU315C, GLU315K, GLY306C, GLY306K, LEU314C, LEU314K, LYS311C, LYS311K, MET307C, MET307K, THR313C, THR313K
• C-L: LEU314C, LYS242L, THR313C
• D-E: ALA12D, ALA239E, ALA241E, ALA243E, ALA24E, ALA258D, ALA260D, ALA26E, ALA278D, ALA2D, ALA383E, ALA384E, ALA3D, ALA46E, ALA481E, ALA57E, ALA71D, ARG118D, ARG13D, ARG18E, ARG197D, ARG231D, ARG268E, ARG284D, ARG285D, ARG322E, ARG36E, ARG58E, ASN112D, ASN206E, ASN21E, ASN229D, ASN265E, ASN37E, ASN433D, ASN457E, ASN68D, ASN68E, ASP115D, ASP179E, ASP253D, ASP25E, ASP283D, ASP359D, ASP361D, ASP41E, ASP523D, ASP5D, ASP64E, CYS458E, CYS519D, GLN184E, GLN432D, GLN436D, GLN453E, GLN72D, GLN72E, GLU186E, GLU214E, GLU216E, GLU232D, GLU238E, GLU252D, GLU255D, GLU257D, GLU303D, GLU308D, GLU310D, GLU386E, GLU388E, GLU460E, GLU483E, GLU518D, GLU59E, GLU61D, GLU61E, GLU63E, GLU76D, GLY180E, GLY182E, GLY244E, GLY256D, GLY269E, GLY280D, GLY282D, GLY32E, GLY35E, GLY382E, GLY459E, GLY45E, GLY512D, GLY70D, GLY9D, ILE227D, ILE230D, ILE270E, ILE49E, ILE515D, ILE60E, LEU183E, LEU237E, LEU23E, LEU40E, LEU456E, LEU513D, LEU524D, LEU62E, LYS117D, LYS207E, LYS225D, LYS226D, LYS242E, LYS245E, LYS272E, LYS277D, LYS286D, LYS28E, LYS34E, LYS364D, LYS380E, LYS390E, LYS42E, LYS4D, LYS51E, LYS65D, LYS65E, LYS75D, LYS75E, LYS7D, LYS80D, MET111D, MET114D, MET16D, MET267E, MET389E, MET514D, MET520D, MET69D, MET73D, PHE281D, PHE44E, PHE66D, PHE8D, PRO113D, PRO246E, PRO279D, PRO33E, PRO47E, SER217E, SER228D, SER358D, SER43E, SER509D, SER55E, THR181E, THR261D, THR266E, THR30E, THR357D, THR385E, THR482E, THR48E, THR50E, THR516D, THR517D, THR522D, TYR203D, TYR360D, VAL107D, VAL22E, VAL240E, VAL271E, VAL27E, VAL29E, VAL381E, VAL387E, VAL38E, VAL39E, VAL455E, VAL510D, VAL521D, VAL56E, VAL6D, VAL74D, VAL77D
• D-F: ALA2D, ALA3D, PHE44F
• D-J: ALA312D, ALA312J, ASP316D, ASP316J, GLU308D, GLU308J, GLU310D, GLU310J, GLU315D, GLU315J, GLY306D, GLY306J, LEU314D, LEU314J, LYS311D, LYS311J, MET307J, THR313D, THR313J
• D-K: LYS242K, THR313D
• E-F: ALA12E, ALA239F, ALA241F, ALA243F, ALA24F, ALA258E, ALA26F, ALA278E, ALA2E, ALA383F, ALA384F, ALA3E, ALA46F, ALA481F, ALA57F, ALA71E, ARG118E, ARG13E, ARG197E, ARG231E, ARG268F, ARG284E, ARG285E, ARG322F, ARG36F, ARG58F, ASN112E, ASN206F, ASN21F, ASN229E, ASN265F, ASN37F, ASN433E, ASN457F, ASN68E, ASN68F, ASP115E, ASP179F, ASP253E, ASP25F, ASP283E, ASP361E, ASP41F, ASP523E, ASP5E, ASP64F, CYS458F, CYS519E, GLN184F, GLN432E, GLN436E, GLN453F, GLN72E, GLN72F, GLU186F, GLU214F, GLU216F, GLU232E, GLU238F, GLU252E, GLU255E, GLU257E, GLU303E, GLU308E, GLU310E, GLU386F, GLU388F, GLU460F, GLU483F, GLU518E, GLU59F, GLU61E, GLU61F, GLU63F, GLU76E, GLY180F, GLY182F, GLY244F, GLY256E, GLY269F, GLY280E, GLY282E, GLY35F, GLY382F, GLY459F, GLY45F, GLY512E, GLY70E, GLY9E, ILE227E, ILE230E, ILE270F, ILE49F, ILE515E, ILE60F, LEU183F, LEU237F, LEU23F, LEU40F, LEU456F, LEU513E, LEU524E, LEU62F, LYS117E, LYS207F, LYS225E, LYS226E, LYS242F, LYS245F, LYS272F, LYS277E, LYS286E, LYS28F, LYS34F, LYS364E, LYS390F, LYS42F, LYS4E, LYS51F, LYS65E, LYS65F, LYS75E, LYS75F, LYS7E, LYS80E, MET111E, MET114E, MET16E, MET267F, MET389F, MET514E, MET520E, MET69E, MET73E, PHE281E, PHE44F, PHE66E, PHE8E, PRO113E, PRO246F, PRO33F, PRO47F, SER217F, SER228E, SER358E, SER43F, SER509E, SER55F, THR181F, THR261E, THR266F, THR30F, THR385F, THR48F, THR50F, THR516E, THR517E, THR522E, TYR203E, TYR360E, VAL107E, VAL22F, VAL240F, VAL271F, VAL27F, VAL29F, VAL381F, VAL387F, VAL38F, VAL39F, VAL455F, VAL510E, VAL521E, VAL56F, VAL6E, VAL74E, VAL77E
• E-G: ALA2E, ALA3E, PHE44G
• E-I: ALA312E, ALA312I, ASP316E, ASP316I, GLU308E, GLU308I, GLU310E, GLU310I, GLY306E, GLY306I, ILE305E, ILE305I, LYS311E, LYS311I, MET307E, MET307I, THR313E, THR313I
• E-J: ALA243J, GLU315E, GLU315J, GLU338E, GLU338J, LYS242J, THR313E
• F-G: ALA12F, ALA239G, ALA241G, ALA243G, ALA24G, ALA258F, ALA26G, ALA278F, ALA2F, ALA383G, ALA384G, ALA3F, ALA46G, ALA481G, ALA57G, ALA71F, ARG118F, ARG13F, ARG18G, ARG197F, ARG231F, ARG268G, ARG284F, ARG285F, ARG322G, ARG36G, ARG58G, ASN112F, ASN206G, ASN21G, ASN229F, ASN265G, ASN37G, ASN433F, ASN457G, ASN68F, ASN68G, ASP115F, ASP179G, ASP253F, ASP25G, ASP283F, ASP359F, ASP361F, ASP41G, ASP435F, ASP523F, ASP5F, ASP64G, CYS458G, CYS519F, GLN184G, GLN432F, GLN436F, GLN453G, GLN72F, GLN72G, GLU186G, GLU214G, GLU216G, GLU232F, GLU238G, GLU252F, GLU255F, GLU257F, GLU303F, GLU308F, GLU310F, GLU386G, GLU388G, GLU460G, GLU483G, GLU518F, GLU59G, GLU61F, GLU61G, GLU63G, GLU76F, GLY180G, GLY182G, GLY244G, GLY256F, GLY269G, GLY280F, GLY282F, GLY32G, GLY35G, GLY382G, GLY459G, GLY45G, GLY512F, GLY70F, GLY9F, ILE227F, ILE230F, ILE270G, ILE49G, ILE515F, ILE60G, LEU183G, LEU237G, LEU23G, LEU40G, LEU456G, LEU513F, LEU524F, LEU62G, LYS117F, LYS207G, LYS225F, LYS226F, LYS242G, LYS245G, LYS272G, LYS277F, LYS286F, LYS28G, LYS34G, LYS364F, LYS380G, LYS390G, LYS42G, LYS4F, LYS51G, LYS65F, LYS65G, LYS75F, LYS7F, LYS80F, MET111F, MET114F, MET16F, MET267G, MET389G, MET514F, MET520F, MET69F, MET73F, PHE281F, PHE44G, PHE66F, PHE8F, PRO113F, PRO246G, PRO279F, PRO33G, PRO47G, SER217G, SER228F, SER358F, SER43G, SER509F, SER55G, SER79F, THR181G, THR266G, THR30G, THR357F, THR385G, THR482G, THR48G, THR50G, THR516F, THR517F, THR522F, TYR203F, TYR360F, VAL107F, VAL22G, VAL240G, VAL271G, VAL27G, VAL29G, VAL381G, VAL387G, VAL38G, VAL39G, VAL455G, VAL510F, VAL521F, VAL56G, VAL6F, VAL74F, VAL77F
• F-H: ALA312F, ALA312H, ASP316F, ASP316H, GLU308F, GLU308H, GLU310F, GLU310H, GLY306F, GLY306H, ILE301F, ILE305F, ILE305H, LEU309H, LEU314H, LYS311F, LYS311H, MET307F, MET307H, PRO235H, THR299F, THR299H, THR313F, THR313H, VAL236H
• F-I: ALA243F, ALA243I, GLU315F, GLU315I, GLU338F, GLU338I, LEU314F, LEU314I, LYS242I, THR313F, THR313I
• G-H: ALA239G, ALA243G, ALA243H, GLU315G, GLU315H, GLU338G, GLU338H, GLU339G, LEU314G, LEU314H, LYS242H, THR313G, THR313H
• G-N: ASP316G, LYS311G, LYS311N
• H-I: ALA12H, ALA239I, ALA241I, ALA243I, ALA24I, ALA258H, ALA26I, ALA278H, ALA2H, ALA383I, ALA384I, ALA3H, ALA46I, ALA481I, ALA57I, ALA71H, ARG118H, ARG13H, ARG197H, ARG231H, ARG268I, ARG284H, ARG285H, ARG322I, ARG36I, ARG58I, ASN112H, ASN206I, ASN21I, ASN229H, ASN265I, ASN37I, ASN433H, ASN457I, ASN68H, ASN68I, ASP115H, ASP179I, ASP253H, ASP25I, ASP283H, ASP361H, ASP41I, ASP523H, ASP5H, ASP64I, CYS458I, CYS519H, GLN184I, GLN432H, GLN436H, GLN453I, GLN72H, GLN72I, GLU186I, GLU214I, GLU216I, GLU232H, GLU238I, GLU252H, GLU255H, GLU257H, GLU303H, GLU308H, GLU310H, GLU386I, GLU388I, GLU460I, GLU483I, GLU518H, GLU59I, GLU61H, GLU61I, GLU63I, GLU76H, GLY180I, GLY182I, GLY244I, GLY256H, GLY269I, GLY280H, GLY282H, GLY35I, GLY382I, GLY459I, GLY45I, GLY512H, GLY70H, GLY9H, ILE227H, ILE230H, ILE270I, ILE49I, ILE515H, ILE60I, LEU183I, LEU237I, LEU23I, LEU40I, LEU456I, LEU513H, LEU524H, LEU62I, LYS117H, LYS207I, LYS225H, LYS226H, LYS242I, LYS245I, LYS272I, LYS277H, LYS286H, LYS28I, LYS34I, LYS364H, LYS390I, LYS42I, LYS4H, LYS51I, LYS65H, LYS65I, LYS75H, LYS75I, LYS7H, LYS80H, MET111H, MET114H, MET16H, MET267I, MET389I, MET514H, MET520H, MET69H, MET73H, PHE281H, PHE44I, PHE66H, PHE8H, PRO113H, PRO246I, PRO279H, PRO33I, PRO47I, PRO525H, SER217I, SER228H, SER358H, SER43I, SER509H, SER55I, THR181I, THR266I, THR30I, THR385I, THR48I, THR50I, THR516H, THR517H, THR522H, TYR203H, TYR360H, VAL107H, VAL22I, VAL240I, VAL271I, VAL27I, VAL29I, VAL381I, VAL387I, VAL38I, VAL39I, VAL510H, VAL521H, VAL56I, VAL6H, VAL74H, VAL77H
• H-J: ALA2H, PHE44J
• H-M: ALA2M, PHE44H
• H-N: ALA2N, ARG284N, ARG285N, ARG36H, ASP115N, ASP25H, ASP41H, ASP523N, ASP5N, GLU216H, GLU255N, GLU257N, GLU303N, GLU308N, GLU386H, GLU518N, GLU59H, GLU61H, GLU63H, LYS226N, LYS242H, LYS245H, LYS272H, LYS277N, LYS34H, LYS4N, LYS65N
• I-J: ALA12I, ALA239J, ALA241J, ALA243J, ALA24J, ALA258I, ALA26J, ALA278I, ALA2I, ALA383J, ALA384J, ALA3I, ALA46J, ALA481J, ALA57J, ALA71I, ARG118I, ARG13I, ARG197I, ARG231I, ARG268J, ARG284I, ARG285I, ARG322J, ARG36J, ARG58J, ASN112I, ASN206J, ASN21J, ASN229I, ASN265J, ASN37J, ASN433I, ASN457J, ASN68I, ASN68J, ASP115I, ASP179J, ASP253I, ASP25J, ASP283I, ASP361I, ASP41J, ASP435I, ASP523I, ASP5I, ASP64J, CYS458J, CYS519I, GLN184J, GLN432I, GLN436I, GLN453J, GLN72I, GLU186J, GLU214J, GLU216J, GLU232I, GLU238J, GLU252I, GLU255I, GLU257I, GLU303I, GLU308I, GLU310I, GLU386J, GLU388J, GLU460J, GLU483J, GLU518I, GLU59J, GLU61I, GLU61J, GLU63J, GLU76I, GLY180J, GLY182J, GLY244J, GLY256I, GLY269J, GLY280I, GLY282I, GLY32J, GLY35J, GLY382J, GLY459J, GLY45J, GLY512I, GLY70I, GLY9I, ILE227I, ILE230I, ILE270J, ILE49J, ILE515I, ILE60J, LEU183J, LEU237J, LEU23J, LEU40J, LEU456J, LEU513I, LEU524I, LEU62J, LYS117I, LYS207J, LYS225I, LYS226I, LYS242J, LYS245J, LYS272J, LYS277I, LYS286I, LYS28J, LYS34J, LYS364I, LYS380J, LYS390J, LYS42J, LYS4I, LYS51J, LYS65I, LYS65J, LYS75I, LYS7I, LYS80I, MET111I, MET114I, MET16I, MET267J, MET389J, MET514I, MET520I, MET69I, MET73I, PHE281I, PHE44J, PHE66I, PHE8I, PRO113I, PRO246J, PRO279I, PRO33J, PRO47J, PRO525I, SER217J, SER228I, SER358I, SER43J, SER509I, THR181J, THR266J, THR30J, THR357I, THR385J, THR482J, THR48J, THR50J, THR516I, THR517I, THR522I, TYR360I, VAL107I, VAL22J, VAL240J, VAL271J, VAL27J, VAL29J, VAL381J, VAL387J, VAL38J, VAL39J, VAL455J, VAL510I, VAL521I, VAL56J, VAL6I, VAL74I, VAL77I
• I-K: ALA2I, PHE44K
• J-K: ALA12J, ALA239K, ALA241K, ALA243K, ALA24K, ALA258J, ALA26K, ALA278J, ALA2J, ALA383K, ALA384K, ALA3J, ALA46K, ALA481K, ALA57K, ALA71J, ARG118J, ARG13J, ARG197J, ARG231J, ARG268K, ARG284J, ARG285J, ARG322K, ARG36K, ARG58K, ASN112J, ASN206K, ASN21K, ASN229J, ASN265K, ASN37K, ASN433J, ASN457K, ASN68J, ASN68K, ASP115J, ASP179K, ASP253J, ASP25K, ASP283J, ASP361J, ASP41K, ASP435J, ASP523J, ASP5J, ASP64K, CYS458K, CYS519J, GLN184K, GLN432J, GLN436J, GLN453K, GLN72J, GLN72K, GLU186K, GLU214K, GLU216K, GLU232J, GLU238K, GLU252J, GLU255J, GLU257J, GLU303J, GLU308J, GLU310J, GLU386K, GLU388K, GLU460K, GLU483K, GLU518J, GLU59K, GLU61J, GLU61K, GLU63K, GLU76J, GLY180K, GLY182K, GLY244K, GLY256J, GLY269K, GLY280J, GLY282J, GLY35K, GLY382K, GLY459K, GLY45K, GLY512J, GLY70J, GLY9J, ILE227J, ILE230J, ILE270K, ILE49K, ILE515J, ILE60K, LEU183K, LEU237K, LEU23K, LEU40K, LEU456K, LEU513J, LEU524J, LEU62K, LYS117J, LYS207K, LYS225J, LYS226J, LYS242K, LYS245K, LYS272K, LYS277J, LYS286J, LYS28K, LYS34K, LYS364J, LYS380K, LYS390K, LYS42K, LYS4J, LYS51K, LYS65J, LYS65K, LYS75J, LYS75K, LYS7J, LYS80J, MET111J, MET114J, MET16J, MET267K, MET389K, MET514J, MET520J, MET69J, MET73J, PHE281J, PHE44K, PHE66J, PHE8J, PRO113J, PRO246K, PRO279J, PRO33K, PRO47K, PRO525J, SER217K, SER228J, SER358J, SER43K, SER509J, SER55K, THR181K, THR261J, THR266K, THR30K, THR385K, THR482K, THR48K, THR50K, THR516J, THR517J, THR522J, TYR360J, VAL107J, VAL22K, VAL240K, VAL271K, VAL27K, VAL29K, VAL381K, VAL387K, VAL38K, VAL39K, VAL455K, VAL510J, VAL521J, VAL56K, VAL6J, VAL74J, VAL77J
• J-L: ALA2J, ALA3J, PHE44L
• K-L: ALA12K, ALA239L, ALA241L, ALA243L, ALA24L, ALA258K, ALA26L, ALA278K, ALA2K, ALA383L, ALA384L, ALA3K, ALA46L, ALA481L, ALA57L, ALA71K, ARG118K, ARG13K, ARG197K, ARG231K, ARG268L, ARG284K, ARG285K, ARG322L, ARG36L, ARG58L, ASN112K, ASN206L, ASN21L, ASN229K, ASN265L, ASN37L, ASN433K, ASN457L, ASN68K, ASN68L, ASP115K, ASP179L, ASP253K, ASP25L, ASP283K, ASP361K, ASP41L, ASP523K, ASP5K, ASP64L, CYS458L, CYS519K, GLN184L, GLN432K, GLN436K, GLN453L, GLN72K, GLN72L, GLU186L, GLU214L, GLU216L, GLU232K, GLU238L, GLU252K, GLU255K, GLU257K, GLU303K, GLU308K, GLU310K, GLU386L, GLU388L, GLU460L, GLU483L, GLU518K, GLU59L, GLU61K, GLU61L, GLU63L, GLU67K, GLU76K, GLY180L, GLY182L, GLY244L, GLY256K, GLY269L, GLY280K, GLY282K, GLY32L, GLY35L, GLY382L, GLY459L, GLY45L, GLY512K, GLY70K, GLY9K, ILE227K, ILE230K, ILE270L, ILE49L, ILE515K, ILE60L, LEU183L, LEU237L, LEU23L, LEU40L, LEU456L, LEU513K, LEU524K, LEU62L, LYS117K, LYS207L, LYS225K, LYS226K, LYS242L, LYS245L, LYS272L, LYS277K, LYS286K, LYS28L, LYS34L, LYS364K, LYS380L, LYS390L, LYS42L, LYS4K, LYS51L, LYS65K, LYS65L, LYS75K, LYS75L, LYS7K, LYS80K, MET111K, MET114K, MET16K, MET267L, MET389L, MET514K, MET520K, MET69K, MET73K, PHE281K, PHE44L, PHE66K, PHE8K, PRO113K, PRO246L, PRO279K, PRO33L, PRO47L, PRO525K, SER217L, SER228K, SER358K, SER43L, SER509K, SER55L, THR181L, THR261K, THR266L, THR30L, THR385L, THR482L, THR48L, THR50L, THR516K, THR517K, THR522K, TYR203K, TYR360K, VAL107K, VAL22L, VAL240L, VAL271L, VAL27L, VAL29L, VAL381L, VAL387L, VAL38L, VAL39L, VAL455L, VAL510K, VAL521K, VAL56L, VAL6K, VAL74K, VAL77K
• K-M: ALA2K, ALA3K, PHE44M
• L-M: ALA12L, ALA239M, ALA241M, ALA243M, ALA24M, ALA258L, ALA26M, ALA278L, ALA2L, ALA383M, ALA384M, ALA3L, ALA46M, ALA57M, ALA71L, ARG118L, ARG13L, ARG197L, ARG231L, ARG268M, ARG284L, ARG285L, ARG322M, ARG36M, ARG58M, ASN112L, ASN206M, ASN21M, ASN229L, ASN265M, ASN37M, ASN433L, ASN68L, ASN68M, ASP115L, ASP179M, ASP253L, ASP25M, ASP283L, ASP361L, ASP41M, ASP523L, ASP5L, ASP64M, CYS519L, GLN184M, GLN432L, GLN436L, GLN72L, GLN72M, GLU186M, GLU214M, GLU216M, GLU232L, GLU238M, GLU252L, GLU255L, GLU257L, GLU303L, GLU308L, GLU310L, GLU386M, GLU388M, GLU518L, GLU59M, GLU61L, GLU61M, GLU63M, GLU67L, GLU76L, GLY180M, GLY182M, GLY244M, GLY256L, GLY269M, GLY280L, GLY282L, GLY32M, GLY35M, GLY382M, GLY45M, GLY512L, GLY70L, GLY9L, ILE227L, ILE230L, ILE270M, ILE49M, ILE515L, ILE60M, LEU183M, LEU237M, LEU23M, LEU40M, LEU513L, LEU524L, LEU62M, LYS117L, LYS207M, LYS225L, LYS226L, LYS242M, LYS245M, LYS272M, LYS277L, LYS286L, LYS28M, LYS34M, LYS364L, LYS390M, LYS42M, LYS4L, LYS51M, LYS65L, LYS65M, LYS75L, LYS75M, LYS7L, LYS80L, MET111L, MET114L, MET16L, MET267M, MET389M, MET514L, MET520L, MET69L, MET73L, PHE281L, PHE44M, PHE66L, PHE8L, PRO113L, PRO246M, PRO279L, PRO33M, PRO47M, PRO525L, SER217M, SER228L, SER358L, SER43M, SER509L, SER55M, THR181M, THR261L, THR266M, THR30M, THR385M, THR48M, THR50M, THR516L, THR517L, THR522L, TYR203L, TYR360L, VAL107L, VAL22M, VAL240M, VAL271M, VAL27M, VAL29M, VAL381M, VAL387M, VAL38M, VAL39M, VAL510L, VAL521L, VAL56M, VAL6L, VAL74L, VAL77L
• M-N: ARG118M, ARG231M, ARG285M, ARG36N, ASN37N, ASP115M, ASP25N, ASP41N, ASP523M, ASP5M, CYS519M, GLU216N, GLU255M, GLU257M, GLU303M, GLU386N, GLU518M, GLU59N, GLU61N, GLU63N, LYS226M, LYS242N, LYS245N, LYS272N, LYS277M, LYS34N, LYS4M, LYS65M, THR516M, VAL39N, VAL521M