2ERJ

crystal structure of the heterotrimeric interleukin-2 receptor in complex with interleukin-2

• Total interactions analyzed: 28
• Total true interactions: 11
• Strongest Interaction:
  • Chains: B-C
  • Int. Res.: 85
  • Norm. En. per Res.: -4.1894
• Hub Node: B(3)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-D	-55.0678	-39.147	-228.638	-322.8527	86	18	2	9137	7	35	23
A-F	0.0	0.0	-0.0036	-0.0036	2	0	0	4	0	0	1
B-C	-63.9633	-58.1651	-233.971	-356.0994	85	15	0	9223	6	34	41
B-D	-24.1334	-59.0992	-150.221	-233.4536	68	4	3	6461	6	27	25
B-F	-7.4631	0.0	-47.7211	-55.1842	30	1	1	2283	0	4	8
C-D	-9.1775	-12.6383	-127.731	-149.5468	67	6	1	5431	0	12	14
D-F	-5.0227	0.0	-18.8765	-23.8992	24	1	0	1050	0	8	7
E-H	-19.8693	-56.2709	-228.148	-304.2882	85	13	2	9024	7	34	22
F-G	-56.1622	-72.9239	-214.836	-343.9221	88	19	0	9192	7	33	42
F-H	-36.5522	-61.5344	-156.645	-254.7315	68	11	3	6792	6	27	25
G-H	-10.4847	-13.233	-128.811	-152.5287	66	10	1	5408	0	12	13

Interface residues

• A-D: ALA108D, ALA112D, ALA114A, ALA73D, ARG35A, ARG36A, ARG38D, ASN27A, ASN57A, ASN71D, ASP109D, ASP4A, ASP56A, ASP5A, ASP6A, CYS105D, CYS147A, CYS28A, CYS30A, CYS3A, CYS58D, CYS61A, GLN57D, GLN58A, GLU106D, GLU1A, GLU29A, GLU60D, GLU61D, GLU62D, GLU67D, GLU68D, GLY152A, GLY23A, GLY33A, GLY40A, HIS120A, ILE114D, ILE118A, ILE37A, LEU26A, LEU2A, LEU36D, LEU40D, LEU42A, LEU45A, LEU59D, LEU63D, LEU66D, LEU70D, LEU72D, LYS153A, LYS31A, LYS35D, LYS38A, LYS43D, LYS64D, MET104D, MET25A, MET39D, MET44A, MET46D, PHE103D, PHE121A, PHE34A, PHE42D, PHE44D, PRO34D, PRO65D, PRO7A, SER39A, SER41A, SER64A, THR111D, THR154A, THR24A, THR37D, THR41D, THR62A, TRP156A, TYR107D, TYR119A, TYR43A, TYR45D, VAL122A, VAL69D
• A-F: GLY26F, SER49A
• B-C: ALA143B, ARG121B, ARG137B, ARG144B, ARG183C, ARG204C, ASN123B, ASN151C, ASN206C, ASP172C, ASP181C, ASP192C, CYS122B, CYS160C, CYS168B, GLN147C, GLN162B, GLN164B, GLN178C, GLN188B, GLN194C, GLU118B, GLU136B, GLU140B, GLU142B, GLU149C, GLU162C, GLU165B, GLU170B, GLU177C, GLY193C, HIS120B, HIS138B, HIS141C, HIS159C, HIS163C, ILE167B, LEU139B, LEU143C, LEU148C, LEU150C, LEU157B, LEU158B, LEU160B, LEU161C, LEU164C, LEU169B, LEU172B, LEU187B, LEU188C, LEU208C, LYS161B, LYS163B, LYS185B, LYS185C, LYS195C, PHE135B, PHE141B, PHE180B, PHE186C, PRO156B, PRO186B, PRO189C, PRO207C, SER144C, SER146C, SER179C, SER187C, SER190C, THR159B, THR169C, THR171B, THR176C, TRP126B, TRP152C, TRP166B, TRP171C, TRP194B, TRP215C, TYR167C, TYR182C, TYR197C, VAL165C, VAL180C, VAL191C
• B-D: ALA16B, ALA66B, ARG137B, ARG15B, ARG41B, ARG42B, ARG43B, ARG81D, ARG83D, ASN88D, ASN90D, ASP20D, ASP40B, ASP68B, ASP76B, ASP84D, GLN13D, GLN188B, GLN22D, GLN70B, GLU102B, GLU136B, GLU15D, GLU95D, GLY189B, GLY65B, HIS133B, HIS138B, HIS16D, HIS79D, ILE24D, ILE77B, ILE86D, ILE89D, ILE92D, LEU104B, LEU12D, LEU14D, LEU17D, LEU187B, LEU18D, LEU19D, LEU21D, LEU64B, LEU72B, LEU80D, LEU85D, LEU94D, LEU96D, LYS71B, LYS8D, LYS99B, LYS9D, MET23D, PHE101B, PHE135B, SER132B, SER14B, SER69B, SER87D, THR10D, THR73B, THR74B, TYR12B, TYR134B, VAL75B, VAL91D, VAL93D
• B-F: ALA16B, ALA37B, ALA66B, ARG42B, ARG43B, ARG85F, ARG89F, ASN45B, ASP68B, CYS33F, GLN130B, GLN34F, GLN46B, GLU49F, GLU86F, GLY65B, GLY87F, ILE63B, LEU62B, LEU64B, LYS71B, PRO39B, PRO67B, SER32F, SER69B, THR31F, THR47B, TRP44B, TRP90F, VAL88F
• C-D: ALA108D, ALA125D, ALA212C, ALA50D, ARG120D, ASN119D, ASN128C, ASN158C, ASN206C, ASN26D, ASN71C, ASP109D, ASP181C, ASP73C, CYS160C, CYS209C, GLN104C, GLN11D, GLN126D, GLN127C, GLN213C, GLN22D, GLU110D, GLU116D, GLU15D, GLY210C, HIS159C, HIS16D, ILE122D, ILE128D, ILE129D, LEU102C, LEU118D, LEU126C, LEU12D, LEU132D, LEU14D, LEU157C, LEU18D, LEU19D, LEU208C, LEU25D, LYS125C, LYS48D, LYS49D, LYS70C, LYS8D, MET123C, MET46D, PHE124D, PHE205C, PRO207C, PRO47D, SER127D, SER130D, SER211C, SER72C, THR105C, THR123D, THR131D, THR133D, THR51D, THR7D, TYR103C, TYR182C, VAL115D, VAL45C
• D-F: ALA56F, ARG81D, ARG83D, ARG85F, ASP30F, ASP84D, CYS84F, GLN55F, GLN74D, GLU49F, GLU86F, GLY87F, HIS79D, LEU51F, LEU80D, LYS76D, PRO52F, PRO82D, SER32F, SER54F, SER57F, THR31F, TRP58F, VAL53F
• E-H: ALA108H, ALA114E, ALA65E, ARG35E, ARG36E, ARG38H, ASN27E, ASN57E, ASN71H, ASP109H, ASP4E, ASP56E, ASP5E, ASP6E, CYS105H, CYS147E, CYS28E, CYS30E, CYS3E, CYS58H, CYS61E, GLN57H, GLN58E, GLN74H, GLU106H, GLU1E, GLU29E, GLU60H, GLU61H, GLU62H, GLU67H, GLU68H, GLY152E, GLY23E, GLY33E, GLY40E, HIS120E, ILE114H, ILE118E, ILE37E, LEU26E, LEU2E, LEU40H, LEU42E, LEU45E, LEU63H, LEU66H, LEU70H, LEU72H, LYS153E, LYS35H, LYS38E, LYS43H, LYS48H, LYS64H, LYS76H, MET104H, MET25E, MET39H, MET44E, MET46H, PHE103H, PHE121E, PHE15E, PHE34E, PHE42H, PHE44H, PRO34H, PRO65H, PRO7E, SER39E, SER41E, SER64E, SER75H, THR111H, THR154E, THR37H, THR41H, TRP156E, TYR107H, TYR119E, TYR43E, TYR45H, VAL122E, VAL69H
• F-G: ALA143F, ARG121F, ARG137F, ARG144F, ARG168G, ARG183G, ARG204G, ASN123F, ASN151G, ASN206G, ASP172G, ASP181G, ASP192G, CYS122F, CYS160G, CYS168F, GLN147G, GLN162F, GLN164F, GLN178G, GLN188F, GLN194G, GLU118F, GLU136F, GLU140F, GLU142F, GLU149G, GLU162G, GLU165F, GLU170F, GLU177G, GLY193G, HIS120F, HIS138F, HIS141G, HIS159G, HIS163G, HIS173G, ILE167F, LEU139F, LEU143G, LEU148G, LEU150G, LEU157F, LEU158F, LEU160F, LEU161G, LEU164G, LEU169F, LEU172F, LEU187F, LEU188G, LEU208G, LYS161F, LYS163F, LYS185F, LYS185G, LYS195G, PHE135F, PHE141F, PHE180F, PHE186G, PRO156F, PRO186F, PRO189G, PRO207G, SER144G, SER146G, SER179G, SER187G, SER190G, THR159F, THR169G, THR171F, THR176G, TRP126F, TRP152G, TRP166F, TRP171G, TRP194F, TRP215G, TYR134F, TYR167G, TYR182G, TYR197G, VAL165G, VAL180G, VAL191G
• F-H: ALA16F, ALA66F, ARG137F, ARG15F, ARG41F, ARG42F, ARG43F, ARG81H, ARG83H, ASN88H, ASN90H, ASP20H, ASP40F, ASP68F, ASP76F, ASP84H, GLN13H, GLN188F, GLN22H, GLN70F, GLU102F, GLU136F, GLU15H, GLU95H, GLY189F, GLY65F, HIS133F, HIS138F, HIS16H, HIS79H, ILE24H, ILE77F, ILE86H, ILE89H, ILE92H, LEU104F, LEU12H, LEU14H, LEU17H, LEU18H, LEU19H, LEU21H, LEU64F, LEU72F, LEU80H, LEU85H, LEU94H, LEU96H, LYS71F, LYS8H, LYS99F, LYS9H, MET23H, PHE101F, PHE135F, PRO39F, SER132F, SER69F, SER87H, THR10H, THR73F, THR74F, TRP44F, TYR12F, TYR134F, VAL75F, VAL91H, VAL93H
• G-H: ALA108H, ALA112H, ALA125H, ALA212G, ALA50H, ARG120H, ASN119H, ASN128G, ASN158G, ASN206G, ASN26H, ASN71G, ASP109H, ASP181G, ASP73G, CYS160G, CYS209G, GLN104G, GLN11H, GLN126H, GLN127G, GLN22H, GLU110H, GLU116H, GLU15H, GLY210G, HIS159G, HIS16H, ILE122H, ILE128H, ILE129H, LEU102G, LEU118H, LEU126G, LEU12H, LEU132H, LEU14H, LEU157G, LEU18H, LEU19H, LEU208G, LEU25H, LYS125G, LYS48H, LYS49H, LYS70G, LYS8H, MET46H, PHE124H, PHE205G, PRO207G, PRO47H, SER127H, SER130H, SER211G, SER72G, THR105G, THR123H, THR131H, THR133H, THR51H, THR7H, TYR103G, TYR182G, VAL115H, VAL45G