2EIM

zinc ion binding structure of bovine heart cytochrome c oxidase in the fully reduced state

• Total interactions analyzed: 325
• Total true interactions: 94
• Strongest Interaction:
  • Chains: R-V
  • Int. Res.: 54
  • Norm. En. per Res.: -6.5002
• Hub Node: A(15)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-65.6212	-76.0375	-837.427	-979.0856	299	33	35	36974	5	37	41
A-C	-80.4418	-84.8863	-750.363	-915.691	245	28	22	29856	6	17	21
A-D	-20.8088	-19.0127	-315.913	-355.7345	148	11	14	12657	2	19	21
A-E	0.0	0.0	-0.0937	-0.0937	10	0	0	29	0	2	1
A-F	-67.9509	-16.2187	-365.653	-449.8226	103	14	9	14080	0	13	5
A-G	-22.1128	2.3003	-84.1327	-103.9452	40	2	0	3471	0	11	3
A-H	0.0	0.0	-19.4193	-19.4193	22	1	0	921	0	3	0
A-I	0.0	0.0	-19.0905	-19.0905	17	0	0	602	0	0	4
A-J	0.0	0.0	-40.7972	-40.7972	36	1	3	2157	0	2	1
A-K	-17.1889	2.1307	-64.9748	-80.033	42	1	0	2720	0	2	4
A-L	-49.06	-1.1347	-461.555	-511.7498	139	24	12	17818	0	22	16
A-M	-89.2419	-25.5	-318.084	-432.8259	96	22	5	11833	3	10	7
A-P	0.0	0.0	-0.0536	-0.0536	5	0	0	25	0	0	1
A-S	0.0	0.0	-0.0035	-0.0035	2	0	0	4	0	0	0
A-T	0.0	0.0	-164.478	-164.478	72	9	7	7090	0	2	1
B-C	0.0	0.0	-1.1143	-1.1143	9	0	0	111	0	1	2
B-D	-34.2171	-3.784	-202.303	-240.3041	81	9	3	8055	3	20	18
B-E	-15.3207	-12.2772	-62.7412	-90.3391	29	1	0	2691	0	8	9
B-F	0.0	0.0	-0.0327	-0.0327	5	0	0	17	0	0	2
B-H	-67.3301	-13.611	-283.839	-364.7802	86	11	2	10508	0	13	8
B-I	-52.4362	-23.9937	-382.931	-459.3609	144	22	10	14908	2	29	38
B-K	0.0	0.0	-36.4421	-36.4421	22	1	0	1434	0	5	3
B-T	0.0	0.0	-2.2758	-2.2758	17	0	0	320	0	0	1
C-F	-24.5709	-28.1143	-239.458	-292.1431	80	4	7	9214	2	28	11
C-G	-52.3124	-42.4086	-444.785	-539.506	154	25	9	17270	2	30	19
C-H	0.0	0.0	-56.903	-56.903	31	0	0	2249	0	4	3
C-J	-33.3869	-2.381	-360.188	-395.9559	118	13	6	15126	3	17	24
C-L	0.0	0.0	-2.4517	-2.4517	6	0	0	134	0	0	1
C-N	0.0	0.0	-0.0359	-0.0359	5	0	0	21	0	0	1
C-S	0.0	0.0	-0.0019	-0.0019	2	0	0	1	0	4	4
C-T	0.0	0.0	-8.1506	-8.1506	16	0	0	633	0	0	2
D-E	-96.566	-30.1472	-420.909	-547.6222	108	25	13	16045	3	46	46
D-F	-10.5979	0.0	-34.5901	-45.188	18	1	0	1191	0	6	1
D-I	-18.8325	-23.0173	-84.5645	-126.4142	48	1	3	3536	2	13	13
D-K	-33.3567	-20.1103	-431.041	-484.508	112	16	8	16160	1	22	24
D-L	0.0	0.0	-0.0918	-0.0918	6	0	0	29	0	1	1
D-M	0.0	0.734	-55.8751	-55.141	51	4	4	2532	0	5	4
E-F	-4.8361	-14.6967	-35.4202	-54.9529	23	3	0	1369	1	7	7
E-I	-51.7264	-93.8641	-172.888	-318.4785	51	9	1	6088	7	20	13
F-G	0.0	0.0	-7.6076	-7.6076	5	0	0	342	0	0	0
F-J	-7.4931	0.0	-30.6244	-38.1175	22	2	0	1055	0	3	3
F-N	0.0	0.0	-0.0043	-0.0043	2	0	0	4	0	0	0
F-P	0.0	0.0	-0.0019	-0.0019	2	0	0	1	0	3	4
F-S	-3.0523	0.0	-16.2405	-19.2928	10	0	0	451	0	0	0
F-T	0.0	-17.3143	-5.4007	-22.715	6	0	0	250	0	4	0
G-H	-5.6805	-7.9931	-52.0844	-65.758	17	1	0	1885	2	6	6
G-N	0.0	0.0	-171.845	-171.845	73	12	7	7168	0	2	1
G-O	0.0	0.0	-1.8747	-1.8747	16	0	0	303	0	0	1
G-P	0.0	0.0	-8.6329	-8.6329	17	0	0	667	0	0	2
G-S	0.0	-15.9835	-5.9201	-21.9037	6	0	0	261	0	4	1
H-U	-8.1253	2.3653	-55.1554	-60.9154	47	7	2	3690	0	17	16
I-K	-2.8733	0.0	-24.5395	-27.4128	12	0	0	722	0	2	3
J-L	-9.1768	2.2844	-31.1299	-38.0223	16	0	0	1223	0	0	4
K-M	0.0	0.0	-0.2136	-0.2136	4	0	0	44	0	0	0
L-M	-24.2887	-10.9741	-170.377	-205.6398	69	4	9	7015	1	4	12
N-O	-82.4938	-68.9517	-853.204	-1004.6495	300	31	34	37375	5	37	42
N-P	-77.7826	-88.6735	-738.196	-904.6521	245	26	20	29602	6	17	21
N-Q	-16.2562	-33.4757	-321.223	-370.955	150	11	15	12898	4	19	22
N-R	0.0	0.0	-0.0631	-0.0631	10	0	0	24	0	2	1
N-S	-72.2425	-16.5746	-356.895	-445.7121	104	20	11	13939	0	13	5
N-T	-36.4526	2.1204	-85.2831	-119.6153	38	2	1	3425	0	11	3
N-U	0.0	0.0	-25.6461	-25.6461	21	1	0	976	0	3	0
N-V	0.0	0.0	-15.9348	-15.9348	16	0	0	582	0	0	4
N-W	0.0	0.0	-41.3837	-41.3837	37	3	3	2165	0	2	1
N-X	-9.1546	1.121	-67.5961	-75.6298	47	2	0	2739	0	2	4
N-Y	-34.1839	-0.5004	-470.043	-504.7273	141	20	12	17929	0	23	15
N-Z	-80.2685	-19.4753	-316.413	-416.1568	96	26	5	11829	3	10	7
O-P	0.0	0.0	-1.1098	-1.1098	8	0	0	106	0	1	2
O-Q	-31.8724	-4.6519	-205.037	-241.5613	84	20	3	8240	3	20	18
O-R	-14.1508	-11.6378	-60.1006	-85.8892	31	0	0	2595	0	8	9
O-S	0.0	0.0	-0.0499	-0.0499	5	0	0	22	0	0	2
O-U	-64.4487	-16.6497	-284.833	-365.9314	90	18	2	10788	1	13	8
O-V	-44.4996	-28.3379	-378.328	-451.1654	143	10	11	14621	2	30	38
O-X	0.0	0.0	-37.4749	-37.4749	22	2	0	1499	0	5	3
P-S	-20.7917	-26.4844	-242.294	-289.5701	82	7	7	9380	2	27	11
P-T	-51.9678	-42.2012	-440.172	-534.341	152	23	9	17088	2	30	18
P-U	0.0	0.0	-58.7896	-58.7896	31	1	0	2320	0	4	3
P-W	-24.8108	-1.1619	-345.147	-371.1197	118	10	7	14815	3	17	24
P-Y	0.0	0.0	-2.64	-2.64	7	0	0	133	0	0	1
Q-R	-73.2198	-41.7973	-435.706	-550.7231	109	24	13	16016	6	45	44
Q-S	-4.7935	0.0	-34.6146	-39.4081	18	1	0	1234	0	6	1
Q-V	-15.6133	-23.1968	-94.6415	-133.4516	47	1	3	3681	2	13	14
Q-X	-22.1518	-29.3702	-439.362	-490.884	111	18	8	16353	2	22	24
Q-Y	0.0	0.0	-0.1206	-0.1206	7	0	0	33	0	1	1
Q-Z	0.0	0.8473	-57.9931	-57.1458	49	2	4	2616	0	5	4
R-S	-8.3536	-18.447	-42.0405	-68.8412	22	2	0	1448	1	7	8
R-V	-90.4132	-97.6484	-162.95	-351.0116	54	16	1	6055	6	20	13
S-T	0.0	0.0	-6.5474	-6.5474	5	1	0	319	0	0	0
S-W	-3.1479	0.0	-29.0852	-32.2331	21	2	0	1056	0	4	4
T-U	-6.918	-7.9148	-55.7493	-70.5821	19	2	0	1965	1	6	6
V-X	-3.028	0.0	-20.7298	-23.7578	11	3	0	763	0	2	3
W-Y	-14.5483	2.6688	-29.7481	-41.6276	16	2	0	1235	0	0	4
X-Z	0.0	0.0	-0.1552	-0.1552	4	0	0	39	0	0	0
Y-Z	-27.3178	-11.6441	-164.145	-203.1069	70	8	8	7041	1	4	12

Interface residues

• A-B: ALA133A, ALA137A, ALA164B, ALA174B, ALA223A, ALA276A, ALA2B, ALA303A, ALA308A, ALA313A, ALA325A, ALA341A, ALA359A, ALA446A, ALA58B, ALA70B, ALA77B, ARG134B, ARG178B, ARG302A, ARG438A, ARG439A, ARG82B, ASN180B, ASN203B, ASN331A, ASN360A, ASN55A, ASP11B, ASP158B, ASP173B, ASP221A, ASP227A, ASP25B, ASP298A, ASP300A, ASP364A, ASP369A, ASP442A, ASP445A, ASP50A, ASP51A, ASP57B, ASP88B, CYS196B, CYS200B, GLN103B, GLN10B, GLN181B, GLN195B, GLN232A, GLN43A, GLN52A, GLN59B, GLN6B, GLU132B, GLU137B, GLU157B, GLU198B, GLU19B, GLU266A, GLU40A, GLU60B, GLU62B, GLU89B, GLY123A, GLY125A, GLY134A, GLY169B, GLY177B, GLY194B, GLY201B, GLY226A, GLY263A, GLY269A, GLY272A, GLY296A, GLY317A, GLY329A, GLY330A, GLY343A, GLY351A, GLY352A, GLY355A, GLY432A, GLY435A, GLY45A, GLY8B, HIS138A, HIS161B, HIS204B, HIS22B, HIS233A, HIS24B, HIS26B, HIS291A, HIS328A, HIS368A, HIS429A, HIS52B, ILE16B, ILE175B, ILE199B, ILE209B, ILE229A, ILE30B, ILE311A, ILE312A, ILE314A, ILE332A, ILE345A, ILE34B, ILE356A, ILE365A, ILE41B, ILE42B, ILE453A, ILE53A, ILE64B, ILE67B, ILE71B, ILE72B, ILE74B, ILE76B, ILE83B, LEU128B, LEU132A, LEU133B, LEU135B, LEU136A, LEU136B, LEU160B, LEU168B, LEU170B, LEU179B, LEU20B, LEU21B, LEU230A, LEU28B, LEU324A, LEU327A, LEU33B, LEU342A, LEU347A, LEU353A, LEU358A, LEU363A, LEU367A, LEU37B, LEU39B, LEU41A, LEU431A, LEU433A, LEU44B, LEU46B, LEU487A, LEU50B, LEU68B, LEU73B, LEU7B, LEU81B, LEU84B, LYS171B, LYS264A, LYS265A, LYS319A, LYS333A, LYS49B, MET122B, MET17B, MET207B, MET271A, MET273A, MET292A, MET297A, MET29B, MET310A, MET338A, MET339A, MET436A, MET449A, MET45B, MET56B, MET5B, MET86B, MET87B, PHE206B, PHE220A, PHE23B, PHE268A, PHE293A, PHE305A, PHE321A, PHE32B, PHE344A, PHE346A, PHE348A, PHE418A, PHE426A, PHE430A, PHE9B, PRO130A, PRO131A, PRO166B, PRO176B, PRO208B, PRO222A, PRO228A, PRO267A, PRO315A, PRO427A, PRO437A, PRO444A, PRO44A, PRO4B, PRO69B, PRO79B, SER156B, SER162B, SER167B, SER197B, SER202B, SER205B, SER262A, SER307A, SER322A, SER35B, SER361A, SER362A, SER36B, SER434A, SER43B, SER441A, SER54B, SER80B, THR124A, THR125B, THR127A, THR172B, THR182B, THR27B, THR294A, THR301A, THR306A, THR309A, THR316A, THR326A, THR349A, THR354A, THR370A, THR448A, THR46A, THR47B, THR48B, THR51B, THR53B, THR55B, THR59A, THR63B, THR66B, TRP104B, TRP106B, TRP126A, TRP163B, TRP275A, TRP323A, TRP334A, TRP450A, TRP65B, TYR129A, TYR193B, TYR231A, TYR261A, TYR270A, TYR304A, TYR372A, TYR3B, TYR40B, TYR440A, TYR443A, TYR447A, TYR54A, TYR85B, VAL128A, VAL159B, VAL165B, VAL258A, VAL295A, VAL299A, VAL318A, VAL31B, VAL320A, VAL350A, VAL357A, VAL366A, VAL38B, VAL56A, VAL58A, VAL61B
• A-C: ALA100C, ALA107C, ALA114A, ALA139A, ALA141A, ALA153A, ALA161A, ALA192A, ALA200C, ALA203A, ALA204A, ALA21C, ALA223A, ALA24C, ALA289A, ALA74C, ALA7C, ALA89A, ALA93A, ARG213A, ARG59C, ARG5A, ARG63C, ARG80C, ARG96A, ASN11A, ASN12C, ASN135A, ASN163A, ASN170A, ASN214A, ASN216A, ASN4A, ASN98A, ASN99A, ASP144A, ASP190C, ASP212A, ASP221A, ASP227A, ASP60C, ASP91A, GLN178A, GLN232A, GLN4C, GLN56C, GLN68C, GLN76C, GLU111C, GLU119A, GLU506A, GLU507A, GLU64C, GLU90C, GLY113C, GLY114C, GLY140A, GLY191C, GLY194C, GLY205A, GLY20C, GLY224A, GLY225A, GLY226A, GLY30C, GLY78C, GLY82C, GLY88A, GLY96C, HIS103C, HIS12A, HIS138A, HIS151A, HIS233A, HIS36C, HIS3C, HIS503A, HIS6C, HIS71C, HIS9C, ILE147A, ILE158A, ILE15A, ILE162A, ILE165A, ILE168A, ILE169A, ILE188C, ILE206A, ILE229A, ILE256C, ILE3A, ILE62C, ILE84C, ILE87A, ILE87C, ILE88C, LEU104A, LEU105A, LEU110A, LEU111A, LEU112A, LEU112C, LEU145A, LEU150A, LEU152A, LEU159A, LEU18C, LEU194A, LEU195A, LEU196A, LEU197A, LEU199A, LEU202A, LEU209A, LEU210A, LEU215A, LEU22C, LEU230A, LEU234A, LEU25C, LEU26C, LEU31C, LEU43C, LEU79C, LEU7A, LEU85C, LEU92C, LYS172A, LYS77C, MET100A, MET10C, MET171A, MET208A, MET27C, MET292A, MET33C, MET54C, MET83C, MET92A, MET97A, PHE101C, PHE102A, PHE109A, PHE148A, PHE164A, PHE197C, PHE198C, PHE203C, PHE219A, PHE220A, PHE233C, PHE237A, PHE238A, PHE285A, PHE305A, PHE35C, PHE37C, PHE505A, PHE86C, PHE8A, PHE93C, PHE94A, PHE94C, PHE97C, PHE98C, PRO106A, PRO107A, PRO108C, PRO110C, PRO118C, PRO13C, PRO15C, PRO173A, PRO174A, PRO17C, PRO200A, PRO222A, PRO228A, PRO508A, PRO73C, PRO84A, PRO90A, PRO95A, SER101A, SER104C, SER105C, SER108A, SER115A, SER142A, SER149A, SER14C, SER189C, SER195C, SER198A, SER23C, SER29C, SER89C, SER9A, THR109C, THR10A, THR146A, THR166A, THR167A, THR187C, THR196C, THR19C, THR207A, THR211A, THR217A, THR218A, THR28C, THR32C, THR504A, THR509A, THR53C, THR5C, THR95C, TRP103A, TRP116C, TRP16C, TRP236A, TRP288A, TRP34C, TRP57C, TRP58C, TRP6A, TRP99C, TYR102C, TYR193C, TYR231A, TYR502A, TYR81C, TYR8C, VAL118A, VAL11C, VAL143A, VAL155A, VAL192C, VAL193A, VAL199C, VAL201A, VAL61C, VAL75C, VAL91C
• A-D: ALA12D, ALA39A, ALA410A, ALA415A, ALA446A, ALA464A, ALA84D, ALA85D, ALA93D, ARG19D, ARG20D, ARG38A, ASN331A, ASN406A, ASN451A, ASN496A, ASN72D, ASP10D, ASP18D, ASP21D, ASP26D, ASP407A, ASP442A, ASP445A, ASP486A, CYS498A, GLN119D, GLN43A, GLU112D, GLU40A, GLU481A, GLU77D, GLU99D, GLU9D, GLY105D, GLY263A, GLY329A, GLY330A, GLY420A, GLY42A, GLY457A, GLY45A, GLY497A, GLY83D, GLY90D, HIS109D, HIS413A, ILE107D, ILE332A, ILE412A, ILE416A, ILE453A, ILE460A, ILE89D, ILE97D, LEU13D, LEU35A, LEU36A, LEU41A, LEU462A, LEU467A, LEU47A, LEU483A, LEU487A, LEU48A, LEU495A, LEU94D, LEU95D, LEU96D, LYS100D, LYS264A, LYS265A, LYS333A, LYS411A, LYS79D, LYS7D, MET123D, MET339A, MET417A, MET423A, MET449A, MET456A, MET466A, MET71D, MET86D, PHE111D, PHE414A, PHE418A, PHE459A, PHE470A, PHE87D, PHE88D, PHE91D, PRO106D, PRO108D, PRO14D, PRO336A, PRO444A, PRO44A, PRO499A, PRO500A, PRO501A, SER15D, SER262A, SER455A, SER458A, SER461A, SER4D, SER8D, THR110D, THR408A, THR448A, THR452A, THR463A, THR46A, THR484A, THR488A, THR489A, THR504A, THR75D, THR80D, THR92D, TRP115D, TRP334A, TRP409A, TRP494A, TRP78D, TRP98D, TYR102D, TYR104D, TYR11D, TYR16D, TYR22D, TYR260A, TYR261A, TYR443A, TYR447A, VAL103D, VAL116D, VAL128D, VAL17D, VAL419A, VAL482A, VAL485A, VAL5D, VAL6D, VAL81D, VAL82D
• A-E: ASN331A, ASP40E, ASP73E, GLY329A, GLY38E, HIS328A, LYS264A, LYS265A, LYS74E, THR35E
• A-F: ALA175A, ALA35F, ALA38F, ARG56F, ASN32F, ASN47F, ASN491A, ASN496A, ASN512A, ASN54F, ASN66F, ASP29F, ASP65F, CYS60F, CYS62F, CYS82F, CYS85F, GLN178A, GLN180A, GLU266A, GLU493A, GLU506A, GLU507A, GLU63F, GLU64F, GLY269A, GLY41F, GLY497A, GLY59F, GLY88A, HIS88F, HIS94F, ILE33F, ILE52F, ILE57F, ILE61F, ILE70F, ILE87A, LEU183A, LEU34F, LEU487A, LEU48F, LEU492A, LEU495A, LEU513A, LEU74F, LEU85A, LEU91F, LEU96F, LYS172A, LYS264A, LYS265A, LYS37F, LYS514A, LYS55F, LYS90F, MET176A, MET271A, MET86A, PHE505A, PHE72F, PRO173A, PRO174A, PRO182A, PRO267A, PRO30F, PRO36F, PRO46F, PRO501A, PRO508A, PRO50F, PRO83F, PRO93F, SER177A, SER40F, SER51F, SER67F, SER84F, THR181A, THR259A, THR39F, THR488A, THR489A, THR490A, THR504A, THR509A, THR53F, THR68F, THR87F, TRP186A, TRP494A, TRP71F, TRP73F, TYR179A, TYR270A, TYR31F, TYR510A, TYR89F, VAL274A, VAL49F, VAL511A, VAL58F, VAL69F
• A-G: ALA139A, ALA141A, ALA223A, ARG213A, ARG54G, ARG56G, ASN135A, ASN214A, ASN216A, ASN66G, ASP144A, ASP212A, ASP221A, GLY134A, GLY140A, GLY224A, GLY225A, GLY226A, GLY65G, HIS51G, HIS52G, HIS67G, ILE55G, LEU136A, LEU210A, LEU215A, LEU53G, LYS58G, PHE60G, PHE69G, PRO222A, PRO59G, PRO79G, SER61G, THR211A, THR217A, THR218A, THR57G, THR68G, TRP62G
• A-H: ALA223A, ARG302A, ARG75H, ASN22H, ASN24H, ASP227A, ASP298A, ASP300A, GLN23H, GLY296A, ILE229A, ILE365A, MET297A, PHE293A, PRO21H, PRO222A, SER361A, THR26H, THR294A, TRP68H, VAL295A, VAL299A
• A-I: ALA14I, ALA325A, ARG15I, ARG16I, ARG18I, ARG43I, GLY329A, GLY330A, HIS328A, ILE21I, LEU12I, LEU13I, LEU17I, LEU324A, LEU327A, LEU433A, LYS264A
• A-J: ALA114A, ALA141A, ALA53J, ARG96A, ASN4A, CYS49J, GLU119A, GLY51J, HIS21J, ILE3A, LEU110A, LEU111A, LEU113A, LEU145A, LEU22J, LEU40J, LEU47J, LEU50J, LEU7A, MET117A, MET36J, PHE55J, PHE8A, PRO107A, PRO19J, PRO56J, SER115A, SER116A, SER142A, SER46J, SER54J, THR43J, TRP52J, TYR32J, VAL118A, VAL20J
• A-K: ALA33K, ALA446A, ASN406A, ASN41K, ASP407A, ASP445A, GLN43A, GLU39K, GLY37K, GLY420A, GLY42A, GLY457A, HIS10K, ILE36K, ILE38K, ILE412A, ILE453A, ILE460A, LYS411A, MET32K, MET423A, MET449A, MET456A, PHE459A, PHE9K, PRO42K, PRO444A, PRO44A, PRO44K, SER43K, SER454A, THR408A, THR448A, THR452A, TRP29K, TRP409A, TRP40K, TRP450A, TYR443A, TYR447A, VAL17K, VAL419A
• A-L: ALA114A, ALA120A, ALA122A, ALA23L, ALA24A, ALA26A, ALA32A, ALA34L, ALA35L, ALA39A, ALA475A, ALA477A, ALA60A, ARG20L, ARG41L, ARG480A, ARG5A, ASN10L, ASN11A, ASN17L, ASN4A, ASP14A, ASP50A, ASP51A, CYS498A, GLN43L, GLN52A, GLU119A, GLU16L, GLU474A, GLU481A, GLU4L, GLU5L, GLY121A, GLY23A, GLY27A, GLY30A, GLY30L, GLY32L, GLY402A, GLY49A, GLY6L, GLY8L, HIS2L, HIS42L, HIS503A, HIS61A, ILE11L, ILE39L, ILE3A, ILE471A, ILE472A, ILE53A, LEU112A, LEU113A, LEU18A, LEU20A, LEU21A, LEU21L, LEU22L, LEU27L, LEU33A, LEU35A, LEU36A, LEU399A, LEU44L, LEU45L, LEU462A, LEU47A, LEU48A, LEU7A, LYS13A, LYS18L, LYS46L, LYS479A, LYS47L, LYS9L, MET117A, MET24L, MET25L, MET28A, MET466A, MET468A, PHE109A, PHE13L, PHE22A, PHE28L, PHE29L, PHE2A, PHE33L, PHE37L, PHE38L, PHE393A, PHE397A, PHE400A, PHE459A, PHE470A, PHE476A, PHE8A, PRO12L, PRO36L, PRO398A, PRO499A, PRO500A, PRO501A, PRO7L, SER115A, SER116A, SER142A, SER14L, SER31L, SER34A, SER401A, SER478A, SER9A, THR10A, THR17A, THR26L, THR31A, THR504A, TRP19L, TRP25A, TRP473A, TRP6A, TRP81A, TYR3L, TYR403A, TYR502A, TYR54A, VAL118A, VAL15L, VAL29A, VAL40L, VAL465A, VAL469A, VAL482A, VAL56A, VAL57A, VAL64A
• A-M: ALA16M, ALA24A, ALA30M, ALA32A, ALA39A, ALA3M, ALA464A, ALA475A, ALA477A, ALA6M, ARG480A, ASN406A, ASP38M, ASP407A, ASP486A, ASP50A, CYS498A, GLN15M, GLU14M, GLU40A, GLU474A, GLU481A, GLY18M, GLY27A, GLY402A, GLY49A, HIS395A, ILE17M, ILE1M, ILE416A, ILE471A, ILE472A, ILE53A, LEU19M, LEU24M, LEU27M, LEU34M, LEU35A, LEU36A, LEU37M, LEU399A, LEU405A, LEU462A, LEU467A, LEU47A, LEU483A, LEU48A, LYS13M, LYS333A, LYS41M, LYS479A, LYS4M, LYS7M, MET28A, MET466A, MET468A, PHE23M, PHE26M, PHE459A, PHE470A, PHE476A, PRO12M, PRO398A, PRO5M, PRO9M, SER11M, SER20M, SER25M, SER335A, SER478A, THR10M, THR22M, THR2M, THR31A, THR404A, THR463A, THR46A, THR484A, THR8M, TRP25A, TRP396A, TRP409A, TRP473A, TRP494A, TYR260A, TYR261A, TYR403A, TYR40M, VAL21M, VAL29A, VAL33M, VAL394A, VAL465A, VAL469A, VAL482A, VAL485A
• A-P: ASN125P, ASP300A, LEU127P, LEU131P, TYR304A
• A-S: ALA1S, MET271A
• A-T: ALA13T, ALA192A, ALA1T, ALA276A, ALA303A, ALA308A, ALA3T, ALA4T, ARG14T, ARG17T, ASN170A, ASN34T, ASP7T, GLN178A, GLN180A, GLY10T, GLY12T, GLY22T, GLY272A, GLY281A, GLY284A, GLY6T, GLY9T, HIS38T, HIS8T, ILE165A, ILE168A, ILE169A, ILE190A, ILE280A, ILE286A, ILE311A, ILE314A, LEU194A, LEU196A, LEU197A, LEU19T, LEU23T, LEU248A, LEU283A, LEU30T, LEU33T, LYS172A, LYS5T, MET176A, MET189A, MET271A, MET273A, MET277A, MET278A, PHE18T, PHE21T, PHE237A, PHE282A, PHE285A, PRO241A, PRO26T, SER177A, SER279A, SER27T, SER2T, SER307A, THR15T, THR191A, TRP16T, TRP186A, TRP275A, TYR179A, TYR270A, TYR304A, VAL193A, VAL274A
• B-C: ALA107C, ARG178B, GLU111C, GLY177B, HIS103C, LEU179B, PRO110C, PRO176B, THR109C
• B-D: ALA117D, ALA129D, ALA12B, ALA136D, ALA2B, ARG122D, ARG134B, ARG141B, ARG188B, ARG19D, ARG20D, ASN72D, ASP11B, ASP125D, ASP21D, GLN10B, GLN119D, GLN132D, GLN6B, GLU114D, GLU127B, GLU132B, GLU137B, GLU18B, GLY131B, GLY133D, GLY190B, GLY8B, HIS109D, HIS22B, HIS52B, ILE107D, ILE123B, ILE131D, LEU128B, LEU133B, LEU135B, LEU136B, LEU191B, LEU21B, LEU50B, LEU7B, LYS118D, LYS121D, LYS127D, LYS129B, LYS137D, LYS49B, MET123D, MET126D, MET5B, PHE111D, PHE134D, PHE9B, PRO108D, PRO124B, PRO130B, PRO130D, PRO189B, PRO4B, SER126B, SER135D, SER167B, SER187B, SER74D, THR110D, THR120D, THR125B, THR13B, THR48B, THR51B, THR53B, TRP115D, TYR192B, TYR193B, TYR22D, TYR3B, VAL116D, VAL128D, VAL138B, VAL210B
• B-E: ALA75E, ASN34E, ASP40E, ASP57B, ASP73E, GLY38E, GLY76E, HIS52B, HIS5E, HIS78E, ILE81E, LEU36E, LEU41E, LEU50B, LYS49B, LYS72E, LYS74E, MET56B, PRO77E, SER54B, THR35E, THR47B, THR48B, THR51B, THR53B, THR55B, TYR39E, VAL37E, VAL42E
• B-F: ASN66F, GLU63F, SER67F, THR55B, THR68F
• B-H: ALA14H, ARG151B, ARG178B, ARG27H, ARG57H, ARG58H, ASN10H, ASN180B, ASN22H, ASN24H, ASN28H, ASN91B, ASN92B, ASP112B, ASP115B, ASP173B, ASP17H, ASP88B, CYS29H, CYS64H, GLN12H, GLN181B, GLN23H, GLN25H, GLU109B, GLU114B, GLU157B, GLU89B, GLY177B, HIS102B, ILE150B, ILE175B, ILE66H, ILE90B, LEU116B, LEU153B, LEU170B, LEU179B, LEU216B, LEU63H, LEU84B, LEU95B, LYS171B, LYS61H, LYS98B, MET100B, MET148B, MET152B, MET87B, PHE118B, PHE16H, PHE20H, PRO15H, PRO176B, PRO21H, PRO65H, PRO93B, SER107B, SER117B, SER155B, SER156B, SER18H, SER62H, SER67H, SER94B, THR111B, THR13H, THR149B, THR172B, THR182B, THR183B, THR26H, THR96B, THR99B, TRP30H, TRP68H, TRP72H, TYR108B, TYR110B, TYR113B, TYR11H, TYR60H, VAL154B, VAL59H, VAL69H, VAL97B
• B-I: ALA12B, ALA14I, ALA24I, ALA32I, ALA40I, ALA46I, ALA48I, ALA72I, ARG141B, ARG15I, ARG16I, ARG188B, ARG18I, ARG43I, ARG64I, ARG82B, ASN140B, ASP11B, ASP139B, ASP25B, ASP55I, ASP59I, GLN10B, GLN70I, GLU132B, GLU137B, GLU147B, GLU18B, GLU19B, GLU212B, GLU220B, GLU41I, GLU61I, GLU62I, GLY11I, GLY190B, GLY23I, GLY30I, GLY67I, GLY8B, HIS20I, HIS22B, HIS24B, HIS26B, HIS52B, ILE123B, ILE21I, ILE30B, ILE34B, ILE41B, ILE64B, ILE68I, LEU12I, LEU13I, LEU144B, LEU17I, LEU191B, LEU211B, LEU213B, LEU216B, LEU21B, LEU28B, LEU29I, LEU33B, LEU37B, LEU44B, LEU46B, LEU50B, LEU68B, LEU7B, LYS129B, LYS217B, LYS221B, LYS36I, LYS42I, LYS44I, LYS45I, LYS49B, LYS58I, LYS73I, MET146B, MET17B, MET185B, MET226B, MET29B, MET45B, MET56B, MET57I, MET63I, MET9I, PHE118B, PHE19I, PHE219B, PHE23B, PHE25I, PHE31I, PHE32B, PHE34I, PHE50I, PHE60I, PHE69I, PHE9B, PRO15B, PRO189B, PRO215B, SER14B, SER167B, SER186B, SER187B, SER223B, SER225B, SER28I, SER36B, SER43B, SER56I, SER71I, THR13B, THR27B, THR33I, THR47B, THR48B, THR51B, THR53B, TRP222B, TRP65B, TYR192B, TYR193B, TYR218B, TYR35I, TYR3B, TYR40B, TYR47I, TYR51I, TYR54I, VAL138B, VAL142B, VAL143B, VAL210B, VAL214B, VAL22I, VAL27I, VAL31B, VAL39I, VAL61B
• B-K: ARG141B, ARG47K, ARG54K, ASN41K, GLN6B, GLU132B, GLU52K, GLY131B, LEU191B, LYS129B, LYS51K, MET5B, PRO130B, PRO42K, PRO44K, PRO4B, SER43K, TRP40K, TRP53K, TYR3B, VAL45K, VAL48K
• B-T: ALA70B, ALA77B, ARG17T, ASN34T, GLN59B, HIS38T, ILE74B, LEU30T, LEU33T, LEU37T, LEU73B, LEU78B, LEU81B, PHE21T, PRO26T, THR66B, TYR85B
• C-F: ALA13F, ALA1F, ALA24F, ALA74C, ALA7C, ALA97F, ARG156C, ARG18F, ARG221C, ARG56F, ARG63C, ASN230C, ASN32F, ASP155C, ASP29F, ASP9F, GLN12F, GLN222C, GLN4C, GLN68C, GLN76C, GLN95F, GLU10F, GLU11F, GLU153C, GLU17F, GLU19F, GLU64C, GLY154C, GLY15F, GLY3F, GLY4F, GLY5F, GLY69C, HIS158C, HIS226C, HIS231C, HIS232C, HIS3C, HIS6C, HIS70C, HIS71C, HIS9C, ILE33F, ILE52F, LEU151C, LEU160C, LEU16F, LEU96F, LYS157C, LYS224C, MET10C, MET152C, MET159C, MET21F, PHE225C, PHE227C, PHE67C, PRO30F, PRO50F, PRO73C, PRO7F, SER150C, SER229C, SER2F, SER51F, SER65C, THR14F, THR228C, THR53F, THR5C, THR66C, THR72C, THR8F, TRP146C, TYR31F, TYR8C, VAL20F, VAL6F, VAL75C
• C-G: ALA139C, ALA13G, ALA147C, ALA162C, ALA178C, ALA184C, ALA24G, ALA29G, ALA46G, ARG14G, ARG17G, ARG42G, ARG44G, ARG54G, ARG56G, ARG74G, ASN125C, ASN133C, ASN34G, ASN38C, ASN66G, ASN72G, ASN76G, ASP155C, ASP190C, CYS115C, CYS31G, GLN161C, GLU111C, GLU128C, GLU153C, GLU180C, GLU183C, GLY10G, GLY113C, GLY114C, GLY120C, GLY12G, GLY141C, GLY154C, GLY191C, GLY194C, GLY202C, GLY22G, GLY40G, GLY63G, HIS122C, HIS148C, HIS149C, HIS158C, HIS243C, HIS36C, HIS38G, HIS41G, HIS51G, HIS52G, HIS67G, HIS71G, ILE121C, ILE144C, ILE165C, ILE188C, ILE48G, ILE55G, LEU112C, LEU124C, LEU127C, LEU131C, LEU132C, LEU137C, LEU138C, LEU151C, LEU169C, LEU175C, LEU176C, LEU19G, LEU23G, LEU25G, LEU30G, LEU31C, LEU33G, LEU37G, LEU53G, LEU78G, LYS157C, LYS58G, MET152C, MET159C, MET33C, MET40C, PHE186C, PHE18G, PHE198C, PHE21G, PHE35C, PHE37C, PHE60G, PHE69G, PHE70G, PRO110C, PRO117C, PRO118C, PRO123C, PRO126C, PRO130C, PRO185C, PRO26G, PRO45G, PRO59G, PRO73G, PRO77G, PRO79G, SER135C, SER140C, SER143C, SER150C, SER179C, SER189C, SER195C, SER27G, SER35G, SER39C, SER39G, SER61G, THR109C, THR119C, THR134C, THR145C, THR15G, THR166C, THR168C, THR187C, THR20G, THR32C, THR32G, THR57G, THR68G, TRP146C, TRP16G, TRP34C, TRP36G, TRP62G, TYR172C, TYR181C, TYR182C, TYR193C, TYR50G, TYR82G, VAL129C, VAL136C, VAL142C, VAL192C, VAL28G, VAL75G
• C-H: ALA107C, ARG27H, ARG38H, ARG75H, ASN24H, ASN28H, CYS115C, CYS29H, GLN31H, GLU111C, GLY113C, GLY114C, GLY120C, GLY83H, LEU112C, LEU34H, LYS84H, PHE81H, PRO108C, PRO110C, PRO118C, PRO82H, THR109C, THR119C, THR26H, THR71H, THR80H, TRP30H, TRP68H, TRP72H, TYR33H
• C-J: ALA21C, ALA24C, ALA53J, ALA6J, ARG156C, ARG221C, ARG33J, ARG4J, ARG59C, ARG63C, ASN12C, ASN29J, ASN38C, ASN3J, ASN50C, ASP28J, ASP60C, CYS39J, CYS49J, GLN13J, GLN222C, GLN56C, GLN68C, GLN9J, GLU14J, GLU2J, GLU64C, GLU7J, GLY20C, GLY24J, GLY25J, GLY30C, GLY41J, GLY42J, GLY46C, GLY69C, HIS21J, HIS226C, HIS36C, HIS57J, HIS70C, HIS9C, ILE30J, ILE45C, ILE62C, LEU11J, LEU160C, LEU18C, LEU18J, LEU223C, LEU22C, LEU22J, LEU25C, LEU26C, LEU31J, LEU38J, LEU40J, LEU42C, LEU43C, LEU44J, LEU47C, LEU47J, LEU50J, LEU52C, LYS10J, LYS224C, LYS23J, LYS8J, MET33C, MET36J, MET40C, MET44C, MET51C, MET54C, PHE12J, PHE1J, PHE219C, PHE220C, PHE225C, PHE227C, PHE37C, PHE55J, PHE67C, PRO13C, PRO15C, PRO17C, PRO19J, SER14C, SER23C, SER29C, SER39C, SER46J, SER54J, SER65C, THR19C, THR228C, THR27J, THR32C, THR35J, THR37J, THR41C, THR43J, THR48C, THR49C, THR53C, THR66C, TRP16C, TRP52J, TRP57C, TYR32J, TYR45J, TYR48J, TYR55C, VAL11C, VAL20J, VAL34J, VAL5J, VAL61C
• C-L: ASN12C, HIS2L, MET10C, PRO13C, TYR3L, VAL11C
• C-N: ASN125C, ASP300N, LEU127C, LEU131C, TYR304N
• C-S: ASP65S, HIS158C
• C-T: ALA1T, ALA3T, ASP7T, GLY10T, GLY9T, HIS8T, ILE84C, ILE88C, LEU85C, LEU92C, LYS77C, SER2T, SER89C, THR95C, TYR81C, VAL91C
• D-E: ALA26E, ALA28D, ALA46D, ALA51E, ALA54E, ALA62E, ALA64E, ALA69D, ARG19D, ARG20D, ARG30E, ARG53E, ARG56E, ARG57E, ARG61D, ARG66E, ARG73D, ASN34E, ASN59E, ASN72D, ASN94E, ASP107E, ASP18D, ASP21D, ASP26D, ASP54D, ASP60E, ASP73E, CYS55E, GLU102E, GLU103E, GLU28E, GLU42D, GLU44D, GLU55D, GLU58D, GLU66D, GLU69E, GLU70D, GLU95E, GLY105E, GLY32E, GLY38E, GLY76E, GLY97E, HIS29D, ILE53D, ILE67E, ILE98E, LEU104E, LEU106E, LEU24D, LEU29E, LEU36E, LEU40D, LEU51D, LEU52E, LEU58E, LEU59D, LEU62D, LEU68E, LEU93E, LEU96E, LYS108E, LYS31E, LYS41D, LYS43D, LYS45D, LYS56D, LYS63D, LYS65D, LYS72E, LYS74E, MET33E, MET71D, PHE19E, PHE61E, PHE64D, PHE68D, PRO101E, PRO14D, PRO23D, PRO25D, PRO77E, SER47D, SER49D, SER50D, SER52D, SER63E, SER67D, SER74D, SER99E, THR100E, THR35E, THR92E, TRP27E, TRP48D, TYR16D, TYR22D, TYR60D, VAL109E, VAL17D, VAL27D, VAL37E, VAL57D, VAL65E, VAL70E, VAL71E
• D-F: ALA12D, ARG56F, ASP10D, ASP26D, GLN80F, GLU9D, HIS75F, ILE57F, LEU13D, LEU74F, LYS55F, LYS76F, PHE72F, PRO14D, PRO83F, TRP73F, TYR11D, TYR22D
• D-I: ALA129D, ALA136D, ALA38I, ALA40I, ALA46I, ALA48I, ALA66I, ARG122D, ARG43I, ARG64I, ASP125D, ASP141D, ASP49I, ASP55I, ASP59I, GLN132D, GLN70I, GLU41I, GLU61I, GLU62I, GLY133D, GLY67I, ILE131D, ILE68I, LEU124D, LYS121D, LYS127D, LYS137D, LYS146D, LYS42I, LYS44I, LYS45I, LYS58I, LYS65I, MET123D, MET126D, MET63I, PHE50I, PHE60I, PHE69I, PRO130D, SER135D, TYR140D, TYR47I, TYR51I, TYR54I, VAL128D, VAL39I
• D-K: ALA117D, ALA136D, ALA16K, ALA19K, ALA22K, ALA27K, ALA33K, ALA6K, ALA84D, ALA85D, ALA93D, ARG122D, ARG47K, ARG54K, ARG73D, ASN143D, ASN15K, ASN41K, ASN76D, ASP11K, ASP125D, ASP8K, CYS25K, GLN119D, GLN132D, GLN35K, GLU112D, GLU113D, GLU114D, GLU144D, GLU39K, GLU52K, GLU77D, GLU99D, GLY105D, GLY133D, GLY14K, GLY21K, GLY37K, GLY46K, GLY83D, GLY90D, HIS101D, HIS10K, ILE107D, ILE36K, ILE38K, ILE89D, ILE97D, LEU124D, LEU18K, LEU94D, LEU95D, LEU96D, LYS100D, LYS118D, LYS121D, LYS12K, LYS137D, LYS146D, LYS147D, LYS51K, LYS79D, MET123D, MET126D, MET32K, MET86D, PHE111D, PHE134D, PHE24K, PHE87D, PHE88D, PHE91D, PHE9K, PRO106D, PRO108D, PRO42K, PRO44K, PRO50K, PRO7K, SER135D, SER20K, SER43K, SER74D, THR110D, THR120D, THR23K, THR34K, THR49K, THR75D, THR80D, THR92D, TRP115D, TRP138D, TRP145D, TRP29K, TRP40K, TRP53K, TRP78D, TRP98D, TYR104D, TYR13K, TYR31K, VAL116D, VAL17K, VAL26K, VAL28K, VAL30K, VAL45K, VAL48K, VAL81D, VAL82D
• D-L: LEU95D, PHE33L, PHE37L, PRO7L, SER8D, VAL103D
• D-M: ALA16M, ALA30M, ALA3M, ARG19D, ASP10D, ASP18D, ASP38M, GLU99D, GLU9D, GLY105D, GLY31M, HIS101D, HIS36M, ILE1M, LEU19M, LEU24M, LEU27M, LEU28M, LEU34M, LEU37M, LEU94D, LEU95D, LYS41M, LYS4M, LYS65D, LYS7D, LYS7M, PHE23M, PHE26M, PHE87D, PHE88D, PHE91D, PRO106D, PRO29M, PRO5M, SER15D, SER20M, SER8D, THR2M, THR92D, TRP32M, TRP98D, TYR102D, TYR104D, TYR16D, TYR35M, VAL103D, VAL17D, VAL33M, VAL5D, VAL6D
• E-F: ARG30E, ARG81F, ASN34E, ASP23E, ASP25E, CYS82F, CYS85F, GLN80F, GLU28E, GLY86F, HIS88F, ILE24E, ILE70F, LEU29E, LYS21E, LYS31E, LYS43F, PRO83F, SER84F, THR35E, THR87F, TRP27E, TYR18E
• E-I: ALA13E, ALA14I, ALA3I, ALA5I, ALA75E, ARG10I, ARG15I, ARG16I, ASP12E, ASP40E, ASP8E, GLN87E, GLN8I, GLU10E, GLU44E, GLU80E, GLU88E, GLU9E, GLY11I, GLY76E, HIS78E, ILE47E, ILE48E, ILE81E, ILE86E, LEU12I, LEU13I, LEU17I, LEU36E, LEU41E, LEU4I, LYS46E, LYS6I, LYS74E, LYS79E, MET9I, PHE11E, PRO43E, PRO45E, PRO77E, PRO7I, PRO83E, THR2I, THR7E, TRP15E, TYR39E, TYR82E, TYR84E, VAL42E, VAL71E, VAL85E
• F-G: ALA13G, ALA1F, ARG14G, ARG17G, SER2F
• F-J: ALA13F, ALA6J, ARG18F, ARG4J, ASN3J, ASP9F, GLN12F, GLN13J, GLN9J, GLU11F, GLU17F, GLY15F, GLY5F, LEU16F, LYS10J, LYS8J, PHE12J, PRO7F, THR14F, THR8F, VAL5J, VAL6F
• F-N: ALA1F, MET271N
• F-P: ASP65F, HIS158P
• F-S: ALA1F, ALA1S, ASP65F, ASP65S, GLU64F, GLU64S, GLY3F, GLY3S, SER2F, SER2S
• F-T: ARG14T, ARG17T, ASN66F, ASP65F, GLU64F, SER67F
• G-H: ARG75H, ASP74H, GLU78H, GLY79H, GLY83H, HIS51G, HIS52G, ILE48G, LEU53G, LYS84H, PHE47G, PHE81H, PRO49G, PRO82H, THR71H, THR80H, TYR50G
• G-N: ALA13G, ALA192N, ALA1G, ALA276N, ALA303N, ALA308N, ALA3G, ALA4G, ARG14G, ARG17G, ASN170N, ASN34G, ASP7G, GLN178N, GLN180N, GLY10G, GLY12G, GLY22G, GLY272N, GLY281N, GLY284N, GLY6G, GLY9G, HIS38G, HIS8G, ILE165N, ILE168N, ILE169N, ILE190N, ILE280N, ILE286N, ILE311N, ILE314N, LEU194N, LEU196N, LEU197N, LEU19G, LEU23G, LEU248N, LEU283N, LEU30G, LEU33G, LYS172N, LYS5G, MET176N, MET189N, MET271N, MET273N, MET277N, MET278N, PHE18G, PHE21G, PHE282N, PHE285N, PRO241N, PRO26G, PRO315N, SER177N, SER279N, SER27G, SER2G, SER307N, THR15G, THR181N, THR191N, TRP16G, TRP186N, TRP275N, TYR179N, TYR270N, TYR304N, VAL193N, VAL274N
• G-O: ALA70O, ALA77O, ASN34G, GLN59O, HIS38G, ILE74O, LEU30G, LEU33G, LEU37G, LEU73O, LEU78O, LEU81O, PHE21G, PRO26G, THR66O, TYR85O
• G-P: ALA1G, ALA3G, ASP7G, GLY10G, GLY9G, HIS8G, ILE84P, ILE87P, ILE88P, LEU85P, LEU92P, LYS77P, SER2G, SER89P, THR95P, TYR81P, VAL91P
• G-S: ARG14G, ARG17G, ASN66S, ASP65S, GLU64S, SER67S
• H-U: ALA42H, ALA42U, ALA45H, ALA45U, ARG19H, ARG19U, ARG57H, ARG57U, ASP49H, ASP49U, CYS39H, CYS39U, CYS53H, CYS53U, GLU54H, GLU54U, GLY47H, GLY47U, GLY48H, GLY48U, ILE8H, ILE8U, LYS46H, LYS46U, LYS7H, LYS7U, LYS84H, LYS84U, LYS9H, LYS9U, MET43H, MET43U, PHE36H, SER18H, SER18U, SER51H, SER51U, THR44H, THR44U, TRP55H, TRP55U, TYR56H, TYR56U, VAL50H, VAL50U, VAL52H, VAL52U
• I-K: ALA66I, ARG54K, ARG64I, GLU52K, GLU62I, GLY67I, ILE68I, LYS65I, LYS73I, MET63I, PHE69I, TRP53K
• J-L: ALA53J, ARG41L, GLN43L, GLY51J, HIS42L, HIS57J, ILE39L, LEU45L, LEU50J, LYS46L, LYS47L, LYS58J, PHE55J, PRO56J, SER54J, TRP52J
• K-M: GLN15M, PHE9K, PRO12M, TYR13K
• L-M: ALA16M, ALA23L, ALA30M, ALA34L, ALA35L, ALA6M, ARG41L, ASN17L, ASN39M, ASP38M, GLN15M, GLN43L, GLU14M, GLU16L, GLY18M, GLY30L, GLY31M, GLY32L, HIS36M, HIS42L, ILE17M, ILE39L, LEU19M, LEU22L, LEU24M, LEU27L, LEU27M, LEU28M, LEU34M, LEU37M, LEU44L, LEU45L, LYS13M, LYS18L, LYS41M, LYS42M, LYS46L, LYS47L, LYS4M, LYS7M, MET25L, PHE23M, PHE26M, PHE28L, PHE29L, PHE33L, PHE37L, PHE38L, PRO29M, PRO36L, PRO7L, PRO9M, SER11M, SER20M, SER25M, SER31L, SER43M, THR10M, THR22M, THR26L, THR8M, TRP19L, TRP32M, TYR35M, TYR40M, VAL15L, VAL21M, VAL33M, VAL40L
• N-O: ALA133N, ALA137N, ALA164O, ALA174O, ALA223N, ALA276N, ALA2O, ALA303N, ALA308N, ALA313N, ALA325N, ALA341N, ALA359N, ALA446N, ALA58O, ALA70O, ALA77O, ARG134O, ARG178O, ARG302N, ARG438N, ARG439N, ARG82O, ASN180O, ASN203O, ASN331N, ASN360N, ASN55N, ASP11O, ASP158O, ASP173O, ASP221N, ASP227N, ASP25O, ASP298N, ASP300N, ASP364N, ASP369N, ASP442N, ASP445N, ASP50N, ASP51N, ASP57O, ASP88O, CYS196O, CYS200O, GLN103O, GLN10O, GLN181O, GLN195O, GLN232N, GLN43N, GLN52N, GLN59O, GLN6O, GLU132O, GLU137O, GLU157O, GLU198O, GLU19O, GLU266N, GLU40N, GLU60O, GLU62O, GLU89O, GLY123N, GLY125N, GLY134N, GLY169O, GLY177O, GLY194O, GLY201O, GLY226N, GLY263N, GLY269N, GLY272N, GLY296N, GLY317N, GLY329N, GLY330N, GLY343N, GLY351N, GLY352N, GLY355N, GLY432N, GLY435N, GLY45N, GLY49N, GLY8O, HIS138N, HIS161O, HIS204O, HIS22O, HIS233N, HIS24O, HIS26O, HIS291N, HIS328N, HIS368N, HIS429N, HIS52O, ILE16O, ILE175O, ILE199O, ILE209O, ILE229N, ILE30O, ILE311N, ILE312N, ILE314N, ILE332N, ILE345N, ILE34O, ILE356N, ILE365N, ILE41O, ILE42O, ILE453N, ILE53N, ILE64O, ILE67O, ILE71O, ILE72O, ILE74O, ILE76O, ILE83O, LEU128O, LEU132N, LEU133O, LEU135O, LEU136N, LEU136O, LEU160O, LEU168O, LEU170O, LEU179O, LEU20O, LEU21O, LEU230N, LEU28O, LEU324N, LEU327N, LEU33O, LEU342N, LEU347N, LEU353N, LEU358N, LEU363N, LEU367N, LEU37O, LEU39O, LEU41N, LEU431N, LEU433N, LEU44O, LEU46O, LEU487N, LEU50O, LEU68O, LEU73O, LEU75O, LEU78O, LEU7O, LEU81O, LEU84O, LYS171O, LYS264N, LYS265N, LYS319N, LYS333N, LYS49O, MET17O, MET207O, MET271N, MET273N, MET292N, MET297N, MET310N, MET338N, MET339N, MET436N, MET449N, MET45O, MET56O, MET5O, MET86O, MET87O, PHE206O, PHE220N, PHE23O, PHE268N, PHE293N, PHE305N, PHE321N, PHE32O, PHE344N, PHE346N, PHE348N, PHE418N, PHE426N, PHE430N, PHE9O, PRO130N, PRO131N, PRO166O, PRO176O, PRO208O, PRO222N, PRO228N, PRO267N, PRO315N, PRO427N, PRO437N, PRO444N, PRO44N, PRO4O, PRO69O, PRO79O, SER156O, SER162O, SER167O, SER197O, SER202O, SER205O, SER262N, SER307N, SER322N, SER35O, SER361N, SER362N, SER36O, SER434N, SER43O, SER441N, SER54O, SER80O, THR124N, THR125O, THR127N, THR172O, THR182O, THR27O, THR294N, THR301N, THR306N, THR309N, THR316N, THR326N, THR349N, THR354N, THR370N, THR448N, THR46N, THR47O, THR48O, THR51O, THR53O, THR55O, THR59N, THR63O, THR66O, TRP104O, TRP106O, TRP126N, TRP163O, TRP275N, TRP323N, TRP334N, TRP450N, TRP65O, TYR129N, TYR193O, TYR231N, TYR270N, TYR304N, TYR372N, TYR3O, TYR40O, TYR440N, TYR443N, TYR447N, TYR54N, TYR85O, VAL128N, VAL159O, VAL165O, VAL258N, VAL295N, VAL299N, VAL318N, VAL31O, VAL320N, VAL350N, VAL357N, VAL366N, VAL373N, VAL38O, VAL56N, VAL58N, VAL61O
• N-P: ALA100P, ALA107P, ALA114N, ALA139N, ALA141N, ALA153N, ALA161N, ALA192N, ALA200P, ALA203N, ALA204N, ALA21P, ALA223N, ALA24P, ALA289N, ALA74P, ALA7P, ALA89N, ALA93N, ARG213N, ARG59P, ARG5N, ARG63P, ARG80P, ARG96N, ASN11N, ASN12P, ASN135N, ASN163N, ASN170N, ASN214N, ASN216N, ASN4N, ASN98N, ASN99N, ASP144N, ASP190P, ASP212N, ASP221N, ASP227N, ASP60P, ASP91N, GLN178N, GLN232N, GLN4P, GLN56P, GLN68P, GLN76P, GLU111P, GLU119N, GLU506N, GLU507N, GLU64P, GLU90P, GLY113P, GLY114P, GLY140N, GLY191P, GLY194P, GLY205N, GLY20P, GLY224N, GLY225N, GLY226N, GLY30P, GLY78P, GLY82P, GLY88N, GLY96P, HIS103P, HIS12N, HIS138N, HIS151N, HIS233N, HIS36P, HIS3P, HIS503N, HIS6P, HIS71P, HIS9P, ILE147N, ILE158N, ILE15N, ILE162N, ILE165N, ILE169N, ILE188P, ILE206N, ILE229N, ILE256P, ILE3N, ILE62P, ILE84P, ILE87N, ILE87P, ILE88P, LEU104N, LEU105N, LEU110N, LEU111N, LEU112N, LEU112P, LEU145N, LEU150N, LEU152N, LEU159N, LEU18P, LEU194N, LEU195N, LEU196N, LEU197N, LEU199N, LEU202N, LEU209N, LEU210N, LEU215N, LEU22P, LEU230N, LEU234N, LEU25P, LEU26P, LEU31P, LEU43P, LEU79P, LEU7N, LEU85P, LEU92P, LYS172N, LYS77P, MET100N, MET10P, MET171N, MET208N, MET27P, MET292N, MET33P, MET54P, MET83P, MET92N, MET97N, PHE101P, PHE102N, PHE109N, PHE148N, PHE164N, PHE197P, PHE198P, PHE203P, PHE219N, PHE220N, PHE233P, PHE235N, PHE237N, PHE238N, PHE285N, PHE305N, PHE35P, PHE37P, PHE505N, PHE86P, PHE8N, PHE93P, PHE94N, PHE94P, PHE97P, PHE98P, PRO106N, PRO107N, PRO108P, PRO110P, PRO118P, PRO13P, PRO15P, PRO173N, PRO174N, PRO17P, PRO200N, PRO222N, PRO228N, PRO508N, PRO73P, PRO84N, PRO90N, PRO95N, SER101N, SER104P, SER105P, SER108N, SER115N, SER142N, SER149N, SER14P, SER189P, SER195P, SER198N, SER23P, SER29P, SER89P, SER9N, THR109P, THR10N, THR146N, THR166N, THR167N, THR187P, THR196P, THR19P, THR207N, THR211N, THR217N, THR218N, THR28P, THR32P, THR504N, THR509N, THR53P, THR5P, THR95P, TRP103N, TRP116P, TRP16P, TRP236N, TRP288N, TRP34P, TRP57P, TRP58P, TRP6N, TRP99P, TYR102P, TYR193P, TYR231N, TYR502N, TYR81P, TYR8P, VAL118N, VAL11P, VAL143N, VAL155N, VAL192P, VAL193N, VAL199P, VAL201N, VAL61P, VAL75P, VAL91P
• N-Q: ALA12Q, ALA39N, ALA410N, ALA415N, ALA446N, ALA464N, ALA84Q, ALA85Q, ALA93Q, ARG19Q, ARG20Q, ARG38N, ASN331N, ASN406N, ASN451N, ASN496N, ASN72Q, ASP10Q, ASP18Q, ASP21Q, ASP26Q, ASP407N, ASP442N, ASP445N, ASP486N, CYS498N, GLN119Q, GLN43N, GLU112Q, GLU40N, GLU481N, GLU77Q, GLU99Q, GLU9Q, GLY105Q, GLY263N, GLY329N, GLY330N, GLY402N, GLY420N, GLY42N, GLY457N, GLY45N, GLY497N, GLY83Q, GLY90Q, HIS109Q, HIS413N, ILE107Q, ILE332N, ILE412N, ILE416N, ILE453N, ILE460N, ILE471N, ILE89Q, ILE97Q, LEU13Q, LEU35N, LEU36N, LEU41N, LEU462N, LEU467N, LEU47N, LEU483N, LEU487N, LEU48N, LEU495N, LEU94Q, LEU95Q, LEU96Q, LYS100Q, LYS264N, LYS265N, LYS333N, LYS411N, LYS79Q, LYS7Q, MET123Q, MET339N, MET417N, MET423N, MET449N, MET456N, MET466N, MET71Q, MET86Q, PHE111Q, PHE414N, PHE418N, PHE459N, PHE470N, PHE68Q, PHE87Q, PHE88Q, PHE91Q, PRO106Q, PRO108Q, PRO14Q, PRO336N, PRO444N, PRO44N, PRO499N, PRO500N, PRO501N, SER15Q, SER262N, SER455N, SER458N, SER461N, SER4Q, SER8Q, THR110Q, THR408N, THR448N, THR452N, THR463N, THR46N, THR484N, THR488N, THR489N, THR504N, THR75Q, THR80Q, THR92Q, TRP115Q, TRP334N, TRP409N, TRP494N, TRP78Q, TRP98Q, TYR102Q, TYR104Q, TYR11Q, TYR16Q, TYR22Q, TYR260N, TYR443N, TYR447N, VAL103Q, VAL116Q, VAL128Q, VAL17Q, VAL419N, VAL482N, VAL485N, VAL5Q, VAL6Q, VAL81Q, VAL82Q
• N-R: ASN331N, ASP40R, ASP73R, GLY329N, GLY38R, HIS328N, LYS264N, LYS265N, LYS74R, THR35R
• N-S: ALA175N, ALA35S, ALA38S, ARG56S, ASN32S, ASN47S, ASN491N, ASN496N, ASN512N, ASN54S, ASN66S, ASP29S, ASP65S, CYS60S, CYS62S, CYS82S, CYS85S, GLN178N, GLN180N, GLU266N, GLU493N, GLU506N, GLU507N, GLU63S, GLU64S, GLY269N, GLY41S, GLY497N, GLY59S, GLY88N, HIS88S, HIS94S, ILE33S, ILE52S, ILE57S, ILE61S, ILE70S, ILE87N, LEU183N, LEU34S, LEU487N, LEU48S, LEU492N, LEU495N, LEU513N, LEU74S, LEU85N, LEU91S, LEU96S, LYS172N, LYS264N, LYS265N, LYS37S, LYS514N, LYS55S, LYS90S, MET176N, MET271N, MET86N, PHE505N, PHE72S, PRO173N, PRO174N, PRO182N, PRO267N, PRO30S, PRO36S, PRO46S, PRO501N, PRO508N, PRO50S, PRO83S, PRO93S, SER177N, SER40S, SER51S, SER67S, SER84S, THR181N, THR259N, THR39S, THR488N, THR489N, THR490N, THR504N, THR509N, THR53S, THR68S, THR87S, TRP186N, TRP494N, TRP71S, TRP73S, TYR179N, TYR270N, TYR31S, TYR510N, TYR89S, VAL274N, VAL49S, VAL511N, VAL58S, VAL69S, VAL92S
• N-T: ALA139N, ALA141N, ALA223N, ARG213N, ARG54T, ARG56T, ASN135N, ASN214N, ASN216N, ASN66T, ASP144N, ASP212N, ASP221N, GLY134N, GLY140N, GLY224N, GLY225N, GLY226N, GLY65T, HIS51T, HIS52T, ILE55T, LEU136N, LEU210N, LEU215N, LEU53T, LYS58T, PHE60T, PHE69T, PRO222N, PRO59T, SER61T, THR211N, THR217N, THR218N, THR57T, THR68T, TRP62T
• N-U: ALA223N, ARG302N, ARG75U, ASN22U, ASN24U, ASP227N, ASP298N, ASP300N, GLN23U, GLY296N, ILE229N, ILE365N, MET297N, PHE293N, PRO21U, PRO222N, THR26U, THR294N, THR301N, VAL295N, VAL299N
• N-V: ALA14V, ALA325N, ARG15V, ARG16V, ARG18V, ARG43V, GLY329N, GLY330N, HIS328N, ILE21V, LEU13V, LEU17V, LEU324N, LEU327N, LEU433N, LYS264N
• N-W: ALA114N, ALA141N, ALA53W, ARG96N, ASN4N, CYS49W, GLU119N, GLY51W, HIS21W, HIS57W, ILE3N, LEU110N, LEU111N, LEU113N, LEU145N, LEU22W, LEU40W, LEU47W, LEU50W, LEU7N, MET117N, MET36W, PHE55W, PHE8N, PRO107N, PRO19W, PRO56W, SER115N, SER116N, SER142N, SER46W, SER54W, THR43W, TRP52W, TYR32W, VAL118N, VAL20W
• N-X: ALA33X, ALA446N, ASN406N, ASN41X, ASN451N, ASP407N, ASP445N, ASP8X, CYS25X, GLN43N, GLU39X, GLY37X, GLY420N, GLY42N, GLY457N, HIS10X, ILE36X, ILE38X, ILE412N, ILE453N, ILE460N, LYS411N, MET32X, MET423N, MET449N, MET456N, PHE459N, PHE9X, PRO42X, PRO444N, PRO44N, PRO44X, SER43X, SER454N, SER455N, SER458N, THR408N, THR448N, THR452N, TRP29X, TRP409N, TRP40X, TRP450N, TYR443N, TYR447N, VAL17X, VAL419N
• N-Y: ALA114N, ALA120N, ALA122N, ALA23Y, ALA24N, ALA26N, ALA32N, ALA34Y, ALA35Y, ALA39N, ALA475N, ALA477N, ALA60N, ARG20Y, ARG41Y, ARG480N, ARG5N, ASN10Y, ASN11N, ASN17Y, ASN4N, ASP14N, ASP50N, ASP51N, CYS498N, GLN43Y, GLN52N, GLU119N, GLU16Y, GLU474N, GLU481N, GLU4Y, GLU506N, GLU5Y, GLY121N, GLY23N, GLY27N, GLY30N, GLY30Y, GLY32Y, GLY402N, GLY49N, GLY6Y, GLY8Y, HIS2Y, HIS42Y, HIS503N, HIS61N, ILE11Y, ILE39Y, ILE3N, ILE471N, ILE472N, ILE53N, LEU112N, LEU113N, LEU18N, LEU20N, LEU21N, LEU21Y, LEU22Y, LEU27Y, LEU33N, LEU35N, LEU36N, LEU399N, LEU44Y, LEU45Y, LEU462N, LEU47N, LEU48N, LEU7N, LYS13N, LYS18Y, LYS46Y, LYS479N, LYS47Y, LYS9Y, MET117N, MET24Y, MET25Y, MET28N, MET466N, MET468N, PHE102N, PHE109N, PHE13Y, PHE22N, PHE28Y, PHE29Y, PHE2N, PHE33Y, PHE37Y, PHE38Y, PHE393N, PHE397N, PHE400N, PHE459N, PHE470N, PHE476N, PHE8N, PRO12Y, PRO36Y, PRO398N, PRO499N, PRO500N, PRO501N, PRO7Y, SER115N, SER116N, SER142N, SER14Y, SER31Y, SER34N, SER401N, SER478N, SER9N, THR10N, THR17N, THR26Y, THR31N, THR504N, TRP19Y, TRP25N, TRP473N, TRP6N, TRP81N, TYR3Y, TYR403N, TYR502N, TYR54N, VAL118N, VAL15Y, VAL29N, VAL40Y, VAL465N, VAL469N, VAL482N, VAL56N, VAL57N, VAL64N
• N-Z: ALA16Z, ALA24N, ALA30Z, ALA32N, ALA39N, ALA3Z, ALA464N, ALA475N, ALA477N, ALA6Z, ARG480N, ASN406N, ASP38Z, ASP407N, ASP486N, ASP50N, CYS498N, GLN15Z, GLU14Z, GLU40N, GLU474N, GLU481N, GLY18Z, GLY27N, GLY402N, GLY49N, HIS395N, ILE17Z, ILE1Z, ILE416N, ILE471N, ILE472N, ILE53N, LEU19Z, LEU24Z, LEU27Z, LEU34Z, LEU35N, LEU36N, LEU37Z, LEU399N, LEU405N, LEU462N, LEU467N, LEU47N, LEU483N, LEU48N, LYS13Z, LYS333N, LYS41Z, LYS479N, LYS4Z, LYS7Z, MET28N, MET466N, MET468N, PHE23Z, PHE26Z, PHE397N, PHE459N, PHE470N, PHE476N, PRO12Z, PRO398N, PRO5Z, PRO9Z, SER11Z, SER20Z, SER25Z, SER335N, SER478N, THR10Z, THR22Z, THR2Z, THR31N, THR404N, THR463N, THR46N, THR484N, THR8Z, TRP396N, TRP409N, TRP473N, TRP494N, TYR260N, TYR261N, TYR403N, TYR40Z, VAL21Z, VAL29N, VAL33Z, VAL394N, VAL465N, VAL469N, VAL482N, VAL485N
• O-P: ALA107P, ARG178O, GLU111P, GLY177O, HIS103P, PRO110P, PRO176O, THR109P
• O-Q: ALA117Q, ALA129Q, ALA12O, ALA136Q, ALA2O, ARG122Q, ARG134O, ARG141O, ARG188O, ARG19Q, ARG20Q, ARG73Q, ASN72Q, ASP11O, ASP125Q, ASP21Q, GLN10O, GLN119Q, GLN132Q, GLN6O, GLU114Q, GLU127O, GLU132O, GLU137O, GLU18O, GLY131O, GLY133Q, GLY190O, GLY8O, HIS109Q, HIS22O, HIS52O, ILE107Q, ILE123O, ILE131Q, LEU128O, LEU133O, LEU135O, LEU136O, LEU191O, LEU21O, LEU50O, LEU7O, LYS118Q, LYS121Q, LYS127Q, LYS129O, LYS137Q, LYS49O, MET123Q, MET126Q, MET5O, MET71Q, PHE111Q, PHE134Q, PHE68Q, PHE9O, PRO108Q, PRO124O, PRO130O, PRO130Q, PRO189O, PRO4O, SER126O, SER135Q, SER167O, SER187O, SER74Q, THR110Q, THR120Q, THR125O, THR13O, THR48O, THR51O, THR53O, TRP115Q, TYR192O, TYR193O, TYR22Q, TYR3O, VAL116Q, VAL128Q, VAL138O, VAL210O
• O-R: ALA75R, ASN34R, ASP40R, ASP57O, ASP73R, GLY38R, GLY76R, HIS52O, HIS5R, HIS78R, ILE81R, LEU36R, LEU41R, LEU50O, LYS49O, LYS72R, LYS74R, LYS79R, MET56O, PRO77R, SER54O, THR35R, THR47O, THR48O, THR51O, THR53O, THR55O, TYR39R, VAL37R, VAL42R, VAL70R
• O-S: ASN66S, GLU63S, SER67S, THR55O, THR68S
• O-U: ALA14U, ARG151O, ARG178O, ARG27U, ARG57U, ARG58U, ASN10U, ASN180O, ASN22U, ASN24U, ASN28U, ASN91O, ASN92O, ASP112O, ASP115O, ASP173O, ASP17U, ASP88O, CYS29U, CYS64U, GLN12U, GLN181O, GLN23U, GLN25U, GLU109O, GLU114O, GLU157O, GLU220O, GLU89O, GLY177O, HIS102O, ILE150O, ILE175O, ILE66U, ILE90O, LEU116O, LEU153O, LEU170O, LEU179O, LEU216O, LEU63U, LEU84O, LEU95O, LYS171O, LYS61U, LYS98O, LYS9U, MET100O, MET148O, MET152O, MET87O, PHE118O, PHE16U, PHE20U, PHE219O, PRO145O, PRO15U, PRO176O, PRO21U, PRO65U, PRO93O, SER107O, SER117O, SER155O, SER156O, SER18U, SER62U, SER67U, SER94O, THR111O, THR13U, THR149O, THR172O, THR182O, THR183O, THR26U, THR96O, THR99O, TRP30U, TRP68U, TRP72U, TYR108O, TYR110O, TYR113O, TYR11U, TYR60U, VAL154O, VAL59U, VAL69U, VAL97O
• O-V: ALA12O, ALA14V, ALA24V, ALA32V, ALA40V, ALA46V, ALA48V, ALA72V, ARG141O, ARG15V, ARG16V, ARG188O, ARG18V, ARG43V, ARG64V, ARG82O, ASN140O, ASP11O, ASP139O, ASP25O, ASP55V, ASP59V, GLN10O, GLN70V, GLU137O, GLU147O, GLU18O, GLU19O, GLU212O, GLU220O, GLU41V, GLU61V, GLU62V, GLY11V, GLY190O, GLY23V, GLY30V, GLY67V, GLY8O, HIS20V, HIS22O, HIS24O, HIS26O, HIS52O, ILE123O, ILE21V, ILE30O, ILE34O, ILE41O, ILE64O, ILE68V, LEU12V, LEU13V, LEU144O, LEU17V, LEU191O, LEU211O, LEU213O, LEU216O, LEU21O, LEU28O, LEU29V, LEU33O, LEU37O, LEU44O, LEU46O, LEU50O, LEU68O, LYS129O, LYS217O, LYS221O, LYS36V, LYS42V, LYS44V, LYS45V, LYS49O, LYS58V, LYS65V, LYS73V, MET146O, MET17O, MET185O, MET226O, MET29O, MET45O, MET56O, MET57V, MET63V, MET9V, PHE118O, PHE19V, PHE219O, PHE23O, PHE25V, PHE31V, PHE32O, PHE34V, PHE50V, PHE60V, PHE69V, PHE9O, PRO15O, PRO189O, PRO215O, SER14O, SER167O, SER186O, SER187O, SER223O, SER225O, SER28V, SER36O, SER43O, SER56V, SER71V, THR13O, THR27O, THR33V, THR47O, THR48O, THR51O, THR53O, TRP222O, TRP65O, TYR192O, TYR193O, TYR218O, TYR35V, TYR3O, TYR40O, TYR47V, TYR51V, TYR54V, VAL138O, VAL142O, VAL143O, VAL210O, VAL214O, VAL22V, VAL27V, VAL31O, VAL39V, VAL61O
• O-X: ARG141O, ARG47X, ARG54X, ASN41X, GLN6O, GLU132O, GLU52X, GLY131O, LEU191O, LYS129O, LYS51X, MET5O, PRO130O, PRO42X, PRO44X, PRO4O, SER43X, TRP40X, TRP53X, TYR3O, VAL45X, VAL48X
• P-S: ALA13S, ALA1S, ALA24S, ALA74P, ALA7P, ALA97S, ARG156P, ARG18S, ARG221P, ARG56S, ARG63P, ASN230P, ASN32S, ASP155P, ASP29S, ASP9S, GLN12S, GLN161P, GLN222P, GLN4P, GLN68P, GLN76P, GLN95S, GLU10S, GLU11S, GLU153P, GLU17S, GLU19S, GLU64P, GLY154P, GLY15S, GLY3S, GLY4S, GLY5S, GLY69P, HIS158P, HIS226P, HIS231P, HIS232P, HIS3P, HIS6P, HIS70P, HIS71P, HIS94S, HIS9P, ILE33S, ILE52S, LEU151P, LEU160P, LEU16S, LEU96S, LYS157P, LYS224P, MET10P, MET152P, MET159P, MET21S, PHE225P, PHE227P, PHE67P, PRO30S, PRO50S, PRO73P, PRO7S, SER150P, SER229P, SER2S, SER51S, SER65P, THR14S, THR228P, THR53S, THR5P, THR66P, THR72P, THR8S, TRP146P, TYR31S, TYR8P, VAL20S, VAL6S, VAL75P
• P-T: ALA139P, ALA13T, ALA147P, ALA162P, ALA178P, ALA184P, ALA24T, ALA29T, ALA46T, ARG14T, ARG17T, ARG42T, ARG44T, ARG54T, ARG56T, ARG74T, ASN125P, ASN133P, ASN34T, ASN38P, ASN66T, ASN72T, ASN76T, ASP155P, ASP190P, CYS115P, CYS31T, GLN161P, GLU111P, GLU128P, GLU153P, GLU180P, GLU183P, GLY10T, GLY113P, GLY120P, GLY12T, GLY141P, GLY154P, GLY191P, GLY194P, GLY22T, GLY40T, GLY63T, HIS122P, HIS148P, HIS149P, HIS158P, HIS243P, HIS36P, HIS38T, HIS41T, HIS51T, HIS52T, HIS67T, HIS71T, ILE121P, ILE144P, ILE165P, ILE188P, ILE48T, ILE55T, LEU112P, LEU124P, LEU127P, LEU131P, LEU132P, LEU137P, LEU138P, LEU151P, LEU169P, LEU175P, LEU176P, LEU19T, LEU23T, LEU25T, LEU30T, LEU31P, LEU33T, LEU37T, LEU53T, LEU78T, LYS157P, LYS58T, MET152P, MET159P, MET33P, MET40P, PHE186P, PHE18T, PHE198P, PHE21T, PHE35P, PHE37P, PHE60T, PHE69T, PHE70T, PRO110P, PRO117P, PRO118P, PRO123P, PRO126P, PRO130P, PRO185P, PRO26T, PRO45T, PRO59T, PRO73T, PRO77T, PRO79T, SER135P, SER140P, SER143P, SER150P, SER179P, SER189P, SER195P, SER27T, SER35T, SER39P, SER39T, SER61T, THR109P, THR119P, THR134P, THR145P, THR15T, THR166P, THR168P, THR187P, THR20T, THR32P, THR32T, THR57T, THR68T, TRP146P, TRP16T, TRP34P, TRP36T, TRP62T, TYR172P, TYR181P, TYR182P, TYR193P, TYR50T, TYR82T, VAL129P, VAL136P, VAL142P, VAL192P, VAL28T, VAL75T
• P-U: ALA107P, ARG27U, ARG38U, ARG75U, ASN24U, ASN28U, CYS115P, CYS29U, GLN31U, GLU111P, GLY113P, GLY114P, GLY120P, GLY83U, LEU112P, LEU34U, LYS84U, PHE81U, PRO108P, PRO110P, PRO118P, PRO82U, THR109P, THR119P, THR26U, THR71U, THR80U, TRP30U, TRP68U, TRP72U, TYR33U
• P-W: ALA21P, ALA24P, ALA53W, ALA6W, ARG156P, ARG221P, ARG33W, ARG4W, ARG59P, ARG63P, ASN12P, ASN29W, ASN3W, ASN50P, ASP28W, ASP60P, CYS39W, CYS49W, GLN13W, GLN222P, GLN56P, GLN68P, GLN9W, GLU14W, GLU2W, GLU64P, GLU7W, GLY17W, GLY20P, GLY24W, GLY25W, GLY30P, GLY41W, GLY42W, GLY46P, GLY51W, GLY69P, HIS21W, HIS226P, HIS36P, HIS57W, HIS70P, HIS9P, ILE30W, ILE45P, ILE62P, LEU11W, LEU160P, LEU18P, LEU18W, LEU223P, LEU22P, LEU22W, LEU25P, LEU26P, LEU31W, LEU38W, LEU40W, LEU42P, LEU43P, LEU44W, LEU47W, LEU50W, LEU52P, LYS10W, LYS224P, LYS23W, LYS8W, MET33P, MET36W, MET40P, MET44P, MET51P, MET54P, PHE12W, PHE1W, PHE220P, PHE225P, PHE227P, PHE37P, PHE55W, PHE67P, PRO13P, PRO15P, PRO17P, PRO19W, PRO56W, SER14P, SER23P, SER29P, SER39P, SER46W, SER54W, SER65P, THR19P, THR228P, THR27W, THR32P, THR35W, THR37W, THR41P, THR43W, THR48P, THR49P, THR53P, THR66P, TRP16P, TRP52W, TRP57P, TYR32W, TYR45W, TYR48W, TYR55P, VAL11P, VAL20W, VAL34W, VAL5W, VAL61P
• P-Y: ASN12P, HIS2Y, MET10P, PRO13P, SER14P, TYR3Y, VAL11P
• Q-R: ALA26R, ALA28Q, ALA46Q, ALA51R, ALA54R, ALA62R, ALA64R, ALA69Q, ALA75R, ARG19Q, ARG20Q, ARG30R, ARG53R, ARG56R, ARG57R, ARG61Q, ARG66R, ARG73Q, ASN34R, ASN59R, ASN72Q, ASN94R, ASP107R, ASP18Q, ASP21Q, ASP26Q, ASP54Q, ASP60R, ASP73R, CYS55R, GLU102R, GLU103R, GLU28R, GLU42Q, GLU44Q, GLU55Q, GLU58Q, GLU66Q, GLU69R, GLU70Q, GLU95R, GLY105R, GLY32R, GLY38R, GLY76R, GLY97R, HIS29Q, ILE53Q, ILE67R, ILE98R, LEU104R, LEU106R, LEU24Q, LEU29R, LEU36R, LEU40Q, LEU51Q, LEU52R, LEU58R, LEU59Q, LEU62Q, LEU68R, LEU93R, LEU96R, LYS108R, LYS31R, LYS41Q, LYS43Q, LYS45Q, LYS56Q, LYS63Q, LYS65Q, LYS72R, LYS74R, MET33R, MET71Q, PHE19R, PHE61R, PHE64Q, PHE68Q, PRO101R, PRO14Q, PRO23Q, PRO25Q, PRO77R, SER47Q, SER49Q, SER50Q, SER52Q, SER63R, SER67Q, SER74Q, SER99R, THR100R, THR35R, THR92R, TRP27R, TRP48Q, TYR16Q, TYR22Q, TYR60Q, VAL109R, VAL17Q, VAL27Q, VAL37R, VAL57Q, VAL65R, VAL70R, VAL71R
• Q-S: ALA12Q, ASN54S, ASP10Q, ASP26Q, GLN80S, GLU9Q, HIS75S, ILE57S, LEU13Q, LEU74S, LYS55S, PHE72S, PRO14Q, PRO83S, SER84S, TRP73S, TYR11Q, TYR22Q
• Q-V: ALA129Q, ALA136Q, ALA38V, ALA40V, ALA46V, ALA48V, ALA66V, ARG122Q, ARG43V, ARG64V, ASP125Q, ASP141Q, ASP49V, ASP59V, GLN132Q, GLN70V, GLU41V, GLU61V, GLU62V, GLY133Q, GLY67V, ILE131Q, ILE68V, LEU124Q, LYS121Q, LYS127Q, LYS137Q, LYS146Q, LYS42V, LYS44V, LYS45V, LYS58V, LYS65V, MET123Q, MET126Q, MET63V, PHE50V, PHE60V, PHE69V, PRO130Q, SER135Q, TYR140Q, TYR47V, TYR51V, TYR54V, VAL128Q, VAL39V
• Q-X: ALA117Q, ALA136Q, ALA16X, ALA19X, ALA22X, ALA27X, ALA33X, ALA6X, ALA84Q, ALA85Q, ALA93Q, ARG122Q, ARG47X, ARG54X, ARG73Q, ASN143Q, ASN15X, ASN41X, ASN76Q, ASP11X, ASP125Q, ASP8X, CYS25X, GLN119Q, GLN132Q, GLN35X, GLU112Q, GLU113Q, GLU114Q, GLU144Q, GLU39X, GLU52X, GLU77Q, GLU99Q, GLY105Q, GLY133Q, GLY14X, GLY21X, GLY37X, GLY46X, GLY83Q, GLY90Q, HIS101Q, HIS10X, ILE107Q, ILE36X, ILE38X, ILE89Q, ILE97Q, LEU124Q, LEU18X, LEU94Q, LEU95Q, LEU96Q, LYS100Q, LYS118Q, LYS121Q, LYS12X, LYS137Q, LYS146Q, LYS147Q, LYS51X, LYS79Q, MET123Q, MET126Q, MET32X, MET86Q, PHE111Q, PHE134Q, PHE24X, PHE87Q, PHE88Q, PHE91Q, PHE9X, PRO106Q, PRO108Q, PRO42X, PRO44X, PRO50X, SER135Q, SER20X, SER43X, SER74Q, THR110Q, THR120Q, THR23X, THR34X, THR49X, THR75Q, THR80Q, THR92Q, TRP115Q, TRP138Q, TRP145Q, TRP29X, TRP40X, TRP53X, TRP78Q, TRP98Q, TYR104Q, TYR13X, TYR31X, VAL116Q, VAL17X, VAL26X, VAL28X, VAL30X, VAL45X, VAL48X, VAL81Q, VAL82Q
• Q-Y: LEU95Q, PHE33Y, PHE37Y, PRO7Y, SER8Q, TRP98Q, VAL103Q
• Q-Z: ALA16Z, ALA30Z, ALA3Z, ASP18Q, ASP38Z, GLU99Q, GLU9Q, GLY105Q, GLY31Z, HIS101Q, HIS36Z, ILE1Z, LEU19Z, LEU24Z, LEU27Z, LEU28Z, LEU34Z, LEU37Z, LEU94Q, LEU95Q, LYS41Z, LYS4Z, LYS65Q, LYS7Q, LYS7Z, PHE23Z, PHE26Z, PHE87Q, PHE88Q, PHE91Q, PRO106Q, PRO29Z, PRO5Z, SER15Q, SER20Z, SER8Q, THR2Z, THR92Q, TRP32Z, TRP98Q, TYR102Q, TYR104Q, TYR16Q, TYR35Z, VAL103Q, VAL17Q, VAL33Z, VAL5Q, VAL6Q
• R-S: ARG30R, ARG81S, ASN34R, ASP25R, CYS82S, CYS85S, GLN80S, GLU28R, GLY86S, HIS88S, ILE24R, ILE70S, LEU29R, LYS21R, LYS31R, LYS43S, PRO83S, SER84S, THR35R, THR87S, TRP27R, TYR18R
• R-V: ALA13R, ALA14V, ALA3V, ALA5V, ALA75R, ARG10V, ARG15V, ARG16V, ASP12R, ASP40R, ASP8R, GLN87R, GLN8V, GLU10R, GLU44R, GLU6R, GLU80R, GLU88R, GLU9R, GLY11V, GLY38R, GLY76R, HIS78R, ILE47R, ILE48R, ILE81R, ILE86R, LEU12V, LEU13V, LEU17V, LEU36R, LEU41R, LEU4V, LEU89R, LYS46R, LYS6V, LYS74R, LYS79R, MET9V, PHE11R, PRO43R, PRO45R, PRO77R, PRO7V, PRO83R, THR2V, THR7R, TRP15R, TYR39R, TYR82R, TYR84R, VAL42R, VAL71R, VAL85R
• S-T: ALA13T, ALA1S, ARG14T, ARG17T, SER2S
• S-W: ALA13S, ALA6W, ARG18S, ARG4W, ASN3W, GLN12S, GLN13W, GLN9W, GLU11S, GLU17S, GLY15S, GLY5S, LEU16S, LYS10W, LYS8W, PHE12W, PRO7S, THR14S, THR8S, VAL5W, VAL6S
• T-U: ARG54T, ARG75U, ASP74U, GLU78U, GLY79U, GLY83U, HIS51T, HIS52T, ILE48T, LEU53T, LYS84U, PHE47T, PHE81U, PRO49T, PRO82U, THR71U, THR80U, TRP72U, TYR50T
• V-X: ALA66V, ARG54X, ARG64V, GLU62V, GLY67V, ILE68V, LYS65V, LYS73V, MET63V, PHE69V, TRP53X
• W-Y: ALA53W, ARG41Y, GLN43Y, GLY51W, HIS42Y, HIS57W, ILE39Y, LEU45Y, LEU50W, LYS46Y, LYS47Y, LYS58W, PHE55W, PRO56W, SER54W, TRP52W
• X-Z: GLN15Z, PHE9X, PRO12Z, TYR13X
• Y-Z: ALA16Z, ALA23Y, ALA30Z, ALA34Y, ALA35Y, ALA6Z, ARG41Y, ASN17Y, ASN39Z, ASP38Z, GLN15Z, GLN43Y, GLU14Z, GLU16Y, GLY18Z, GLY30Y, GLY31Z, GLY32Y, HIS36Z, HIS42Y, ILE17Z, ILE39Y, LEU19Z, LEU22Y, LEU24Z, LEU27Y, LEU27Z, LEU28Z, LEU34Z, LEU37Z, LEU44Y, LEU45Y, LYS13Z, LYS18Y, LYS41Z, LYS42Z, LYS46Y, LYS47Y, LYS4Z, LYS7Z, MET25Y, PHE23Z, PHE26Z, PHE28Y, PHE29Y, PHE33Y, PHE37Y, PHE38Y, PRO12Z, PRO29Z, PRO36Y, PRO7Y, PRO9Z, SER11Z, SER20Z, SER25Z, SER31Y, SER43Z, THR10Z, THR22Z, THR26Y, THR8Z, TRP19Y, TRP32Z, TYR35Z, TYR40Z, VAL15Y, VAL21Z, VAL33Z, VAL40Y