2EHO

crystal structure of human gins complex

• Total interactions analyzed: 66
• Total true interactions: 24
• Strongest Interaction:
  • Chains: E-G
  • Int. Res.: 155
  • Norm. En. per Res.: -4.0933
• Hub Node: B(4)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-22.3034	-18.5789	-350.914	-391.7963	141	19	14	15696	1	41	45
A-C	-49.9251	-63.5407	-301.768	-415.2338	124	28	7	13244	4	32	26
A-D	-8.9676	4.865	-46.6816	-50.7842	36	6	3	2253	1	12	11
B-C	0.0	-3.9814	-20.0377	-24.0191	22	0	0	1166	0	9	7
B-D	-30.5659	-23.9365	-396.779	-451.2814	134	42	16	16449	5	43	41
B-F	-8.0909	17.0703	-78.3231	-69.3438	49	17	0	3862	0	28	28
B-H	0.0	0.0	-46.1534	-46.1534	46	7	0	2065	0	15	15
C-D	-7.3638	-22.5963	-260.753	-290.7131	119	16	11	11770	2	32	31
D-F	-2.1823	-0.9139	-53.3931	-56.4893	50	11	1	2745	0	19	17
D-H	0.0	0.0	-0.3656	-0.3656	3	0	0	42	0	0	0
E-F	-30.0892	-40.3927	-353.44	-423.9219	144	17	14	16212	3	45	50
E-G	-92.3601	-116.062	-426.041	-634.4632	155	32	10	18130	6	57	48
E-H	-12.229	-11.7715	-44.3757	-68.3762	41	1	3	2189	2	13	10
F-G	0.0	-1.8219	-20.7541	-22.576	22	0	0	998	0	9	6
F-H	-48.8032	-96.3721	-364.686	-509.8613	132	32	15	16450	14	46	45
G-H	0.0	9.0929	-328.872	-319.7791	127	10	12	13688	1	35	31
G-K	0.0	0.0	-0.0388	-0.0388	4	0	0	22	0	3	2
H-K	-12.4243	-34.5939	-96.9293	-143.9475	63	2	2	4485	5	22	26
I-J	-14.3931	-42.3305	-374.379	-431.1025	145	22	13	16577	2	45	50
I-K	-82.0899	-98.738	-389.886	-570.714	153	50	10	18285	8	58	47
I-L	0.0	-2.1158	-40.3584	-42.4742	41	1	3	2007	1	14	11
J-K	0.0	-4.2731	-19.5088	-23.7819	23	0	0	1193	0	9	9
J-L	-29.588	-61.506	-375.312	-466.406	130	30	15	16298	10	44	41
K-L	-13.139	2.2772	-315.069	-325.9308	131	21	12	13628	3	31	30

Interface residues

• A-B: ALA107B, ALA108B, ALA122B, ALA128A, ALA130A, ALA135A, ALA145A, ALA161A, ALA38B, ALA78B, ALA89B, ARG119B, ARG126B, ARG160A, ARG30B, ARG71B, ARG73B, ARG74B, ARG83B, ARG84A, ARG86A, ARG88B, ARG91B, ARG94A, ARG96A, ASN115B, ASN116B, ASN136A, ASN143A, ASN152A, ASN72B, ASP131B, ASP135B, ASP139B, ASP157A, ASP82B, CYS95A, GLN138B, GLN154A, GLN44B, GLN79A, GLU101A, GLU109B, GLU110B, GLU112B, GLU125A, GLU126A, GLU132A, GLU138A, GLU26B, GLU34B, GLU35B, GLU41B, GLU52A, GLU56A, GLU59A, GLU62A, GLU83A, GLY129B, GLY130B, GLY133B, HIS148A, HIS66B, ILE100A, ILE136B, ILE85A, ILE87B, LEU121B, LEU122A, LEU127A, LEU128B, LEU134B, LEU141A, LEU146A, LEU153A, LEU158A, LEU29B, LEU33B, LEU39B, LEU58A, LEU69B, LEU70B, LEU80B, LEU84B, LEU85B, LEU89A, LEU93A, LEU97A, LYS102A, LYS118B, LYS141B, LYS142A, LYS144B, LYS147A, LYS155A, LYS37B, LYS99A, PHE103A, PHE104A, PHE114B, PHE129A, PHE133A, PHE24B, PRO105A, PRO124A, PRO142B, PRO143B, PRO150A, PRO151A, PRO163A, SER120B, SER123A, SER127B, SER139A, SER145B, SER68B, SER90A, SER91A, THR123B, THR137A, THR137B, THR76B, TRP113B, TRP34A, TRP92B, TYR117B, TYR124B, TYR140A, TYR40B, TYR79B, TYR81B, TYR87A, TYR92A, VAL144A, VAL156A, VAL162A, VAL32B, VAL51A, VAL54A, VAL77B, VAL88A
• A-C: ALA10C, ALA132C, ALA163C, ALA24A, ALA49C, ALA4C, ARG171C, ARG174A, ARG207A, ARG55C, ARG84A, ARG86A, ARG94A, ASN147C, ASN154C, ASN165C, ASN20C, ASN51C, ASP146C, ASP166A, ASP168A, ASP24C, ASP2C, ASP32C, ASP72A, CYS95A, GLN139C, GLN162C, GLN203A, GLN57A, GLN79A, GLU11C, GLU13C, GLU152C, GLU25A, GLU28A, GLU31A, GLU59A, GLU5C, GLU62A, GLU71A, GLU7C, GLU81A, GLU83A, GLY157C, GLY30C, GLY31C, HIS166C, HIS204A, HIS60A, HIS78A, ILE153C, ILE206A, ILE26C, ILE27A, ILE29C, ILE77A, ILE85A, LEU128C, LEU148C, LEU150C, LEU160C, LEU164C, LEU167A, LEU173A, LEU205A, LEU23C, LEU26A, LEU28C, LEU33C, LEU46C, LEU48C, LEU52C, LEU58A, LEU65A, LEU73A, LEU89A, LEU98C, LEU9C, LYS12C, LYS169C, LYS209A, LYS25C, LYS38A, LYS57C, LYS74A, PHE135C, PHE172A, PHE21C, PHE36C, PHE39A, PHE8C, PRO19C, PRO23A, PRO35C, PRO41A, PRO45C, PRO90C, SER169A, SER202A, SER22C, SER76A, SER91A, THR149C, THR158C, THR161C, THR172C, THR210A, THR22A, TRP34A, TRP47C, TYR168C, TYR170A, TYR208A, TYR27C, TYR87A, TYR91C, VAL136C, VAL171A, VAL44C, VAL54A, VAL6C, VAL75A, VAL88A
• A-D: ALA161A, ALA4D, ARG160A, ARG7D, ARG94A, ASN18D, ASP157A, ASP166A, GLU101A, GLU17D, GLU9D, GLY11D, HIS106A, ILE100A, LEU141A, LEU146A, LEU158A, LEU20D, LEU97A, LYS102A, LYS164A, LYS99A, PHE103A, PHE104A, PHE133A, PHE19D, PHE6D, PRO105A, PRO163A, PRO165A, SER10D, SER21D, THR137A, VAL156A, VAL162A, VAL8D
• B-C: ALA3C, ALA4C, ARG55C, ASN51C, ASP2C, GLN54C, GLU11C, GLU5C, GLU7C, HIS102C, ILE50C, LEU98C, LEU9C, LYS141B, LYS144B, LYS97C, PHE8C, PRO142B, PRO143B, SER145B, TRP47C, VAL6C
• B-D: ALA12D, ALA16B, ALA39D, ALA4D, ALA50B, ALA59D, ALA6B, ALA73D, ALA78B, ALA89B, ARG11B, ARG15B, ARG173D, ARG42D, ARG55B, ARG65B, ARG71B, ARG73B, ARG74B, ARG7D, ARG82D, ARG83B, ARG86B, ARG88B, ARG91B, ASN18D, ASN43B, ASN58D, ASN72B, ASP23D, ASP24D, ASP46B, ASP57B, ASP78D, ASP82B, CYS3B, CYS67B, CYS75B, GLN122D, GLN177D, GLN20B, GLN42B, GLN62D, GLU12B, GLU16D, GLU170D, GLU17D, GLU18B, GLU30D, GLU35B, GLU37D, GLU3D, GLU49B, GLU4B, GLU67D, GLU8B, GLU93B, GLU9D, GLY11D, GLY192D, GLY19B, GLY44D, GLY75D, HIS115D, HIS14B, HIS29D, HIS66B, ILE10B, ILE25D, ILE59B, ILE62B, ILE83D, ILE87B, LEU13B, LEU20D, LEU22D, LEU26D, LEU32D, LEU39B, LEU43D, LEU58B, LEU66D, LEU68D, LEU69B, LEU70B, LEU70D, LEU72D, LEU76D, LEU80B, LEU84B, LEU84D, LEU85B, LEU90B, LEU9B, LYS144B, LYS191D, LYS31D, LYS5B, LYS63B, LYS74D, PHE19D, PHE2B, PHE46D, PHE47D, PHE64B, PHE6D, PHE77D, PRO142B, PRO17B, PRO41D, PRO60B, PRO69D, SER10D, SER21D, SER28D, SER45B, SER56B, SER68B, THR36D, THR38D, THR61B, THR76B, TRP189D, TRP71D, TRP92B, TYR117B, TYR5D, TYR79B, TYR81B, TYR94B, VAL34D, VAL60D, VAL77B, VAL8D
• B-F: ALA101F, ALA16B, ALA16F, ALA23B, ALA23F, ARG103F, ARG11B, ARG11F, ARG15B, ARG15F, ARG83F, ARG86B, ARG86F, ASN100F, ASN25B, GLN20B, GLN20F, GLN31B, GLU12B, GLU12F, GLU18B, GLU18F, GLU4B, GLU8B, GLU93F, GLY19B, GLY19F, GLY28B, HIS105B, HIS105F, HIS14B, HIS14F, LEU102F, LEU13B, LEU13F, LEU21B, LEU21F, LEU90F, LEU9B, LYS5B, PHE104F, PHE24F, PRO17B, PRO17F, PRO22B, PRO22F, PRO99F, TYR79B, TYR94F
• B-H: ALA101B, ALA108B, ALA156H, ALA166H, ARG103B, ARG173H, ARG30B, ASN100B, ASN155H, ASN158H, ASN184H, ASP185H, ASP27B, CYS188H, GLN177H, GLN180H, GLN187H, GLN193H, GLN31B, GLU159H, GLU190H, GLU26B, GLU34B, GLY179H, GLY182H, HIS105B, HIS110H, ILE97B, LEU102B, LEU183H, LEU98B, LYS111H, LYS181H, LYS191H, PHE104B, PHE176H, PHE186H, PRO99B, SER153H, SER162H, THR161H, THR178H, TRP189H, TYR157H, TYR94B, VAL165H
• C-D: ALA10C, ALA126C, ALA12D, ALA132C, ALA132D, ALA163C, ALA3C, ALA4C, ARG114C, ARG129C, ARG137C, ARG145D, ARG147D, ARG148D, ARG171C, ARG7D, ASN101C, ASN105D, ASN131D, ASN154C, ASN155D, ASN165C, ASN173C, ASN184D, ASN18D, ASP122C, ASP133C, ASP151D, ASP185D, ASP2C, CYS188D, GLN122D, GLN136D, GLN138C, GLN139C, GLN140D, GLN154D, GLN162C, GLN177D, GLN180D, GLN187D, GLU11C, GLU152C, GLU16D, GLU170D, GLU172D, GLU190D, GLU5C, GLU7C, GLU94C, GLU9D, GLY118D, GLY11D, GLY120D, GLY144D, GLY14D, GLY157C, GLY174D, GLY179D, GLY182D, GLY192D, HIS125D, HIS166C, ILE125C, ILE134D, ILE143D, ILE149D, LEU124D, LEU128C, LEU138D, LEU139D, LEU13D, LEU160C, LEU164C, LEU170C, LEU175D, LEU183D, LEU95C, LEU98C, LYS118C, LYS169C, LYS181D, LYS191D, LYS97C, PHE116D, PHE135C, PHE142D, PHE146D, PHE159C, PHE176D, PHE186D, PHE8C, PRO15D, SER10D, SER121D, SER131C, SER134C, SER135D, SER137D, SER152D, SER153D, SER156C, THR141D, THR149C, THR155C, THR158C, THR161C, THR172C, THR178D, THR96C, TRP121C, TRP189D, TYR117D, TYR168C, TYR91C, TYR92C, VAL130C, VAL136C, VAL6C
• D-F: ALA101F, ALA107F, ALA108F, ALA163D, ALA166D, ALA23F, ARG103F, ARG119F, ARG173D, ARG30F, ASN100F, ASN115F, ASN158D, ASN184D, ASN25F, ASP108D, ASP160D, ASP27F, GLN177D, GLN180D, GLU112F, GLU159D, GLU170D, GLU172D, GLU26F, GLY174D, GLY179D, HIS105F, HIS110D, ILE97F, LEU164D, LEU168D, LEU175D, LEU26D, LYS111D, LYS118F, LYS181D, PHE104F, PHE114F, PHE176D, PHE24F, PRO114D, PRO99F, SER152D, SER153D, SER162D, THR161D, THR178D, TYR157D, VAL165D
• D-H: GLU49D, LEU48D, PHE46H
• E-F: ALA107F, ALA108F, ALA122F, ALA128E, ALA130E, ALA135E, ALA145E, ALA161E, ALA38F, ALA78F, ALA89F, ARG119F, ARG131E, ARG160E, ARG30F, ARG71F, ARG73F, ARG74F, ARG83F, ARG84E, ARG86E, ARG88F, ARG91F, ARG94E, ARG96E, ASN115F, ASN116F, ASN136E, ASN143E, ASN152E, ASN43F, ASN72F, ASP131F, ASP135F, ASP139F, ASP157E, ASP82F, CYS95E, GLN138F, GLN154E, GLN44F, GLN79E, GLU101E, GLU109F, GLU110F, GLU112F, GLU125E, GLU126E, GLU132E, GLU132F, GLU138E, GLU26F, GLU34F, GLU35F, GLU41F, GLU52E, GLU56E, GLU59E, GLU62E, GLU81E, GLU83E, GLY129F, GLY130F, GLY133F, HIS148E, HIS66F, ILE100E, ILE136F, ILE85E, ILE87F, LEU121F, LEU122E, LEU127E, LEU128F, LEU134F, LEU141E, LEU146E, LEU153E, LEU158E, LEU29F, LEU33F, LEU39F, LEU58E, LEU69F, LEU70F, LEU80F, LEU84F, LEU85F, LEU89E, LEU93E, LEU97E, LYS102E, LYS118F, LYS141F, LYS142E, LYS144F, LYS147E, LYS155E, LYS37F, LYS99E, PHE103E, PHE104E, PHE114F, PHE129E, PHE133E, PHE24F, PRO105E, PRO124E, PRO142F, PRO143F, PRO150E, PRO151E, PRO163E, SER120F, SER123E, SER127F, SER139E, SER145F, SER76E, SER90E, SER91E, THR123F, THR137E, THR137F, THR76F, TRP113F, TRP34E, TRP92F, TYR117F, TYR124F, TYR140E, TYR40F, TYR79F, TYR81F, TYR87E, TYR92E, VAL144E, VAL156E, VAL162E, VAL32F, VAL51E, VAL54E, VAL77F, VAL88E
• E-G: ALA10G, ALA132G, ALA141G, ALA143G, ALA163G, ALA24E, ALA4G, ARG137G, ARG171G, ARG174E, ARG176E, ARG192E, ARG207E, ARG55G, ARG84E, ARG86E, ARG94E, ASN147G, ASN154G, ASN165G, ASN51G, ASN64E, ASP146G, ASP166E, ASP168E, ASP187E, ASP189E, ASP193E, ASP197E, ASP24G, ASP2G, ASP32G, ASP72E, CYS58G, CYS95E, GLN138G, GLN139G, GLN162G, GLN203E, GLN57E, GLN79E, GLU11G, GLU13G, GLU140G, GLU185E, GLU190E, GLU199E, GLU25E, GLU28E, GLU31E, GLU56E, GLU5G, GLU62E, GLU71E, GLU7G, GLU81E, GLU83E, GLY157G, GLY201E, GLY30G, GLY31G, HIS142G, HIS166G, HIS204E, HIS60E, HIS78E, ILE153G, ILE182E, ILE196E, ILE206E, ILE211E, ILE26G, ILE27E, ILE29G, ILE77E, ILE85E, LEU128G, LEU145G, LEU148G, LEU150G, LEU160G, LEU164G, LEU167E, LEU173E, LEU183E, LEU198E, LEU205E, LEU23G, LEU26E, LEU28G, LEU30E, LEU33G, LEU46G, LEU48G, LEU52G, LEU58E, LEU65E, LEU73E, LEU89E, LEU9G, LYS12G, LYS144G, LYS169G, LYS209E, LYS25G, LYS38E, LYS57G, LYS74E, PHE135G, PHE159G, PHE172E, PHE21G, PHE36G, PHE39E, PHE8G, PRO186E, PRO19G, PRO23E, PRO35G, PRO41E, PRO45G, PRO90G, SER156G, SER169E, SER202E, SER22G, SER76E, SER91E, THR149G, THR155G, THR158G, THR161G, THR172G, THR188E, THR210E, THR22E, TRP34E, TRP47G, TYR168G, TYR170E, TYR194E, TYR208E, TYR27G, TYR87E, TYR91G, TYR92E, VAL136G, VAL171E, VAL175E, VAL184E, VAL44G, VAL54E, VAL6G, VAL75E, VAL88E
• E-H: ALA161E, ALA4H, ARG160E, ARG7H, ARG94E, ASN18H, ASP157E, ASP166E, ASP187E, ASP189E, GLN136H, GLU101E, GLU16H, GLU17H, GLU9H, GLY11H, HIS106E, ILE100E, LEU139H, LEU141E, LEU146E, LEU158E, LEU20H, LEU97E, LYS102E, LYS164E, LYS99E, PHE103E, PHE104E, PHE129E, PHE133E, PHE19H, PHE6H, PRO105E, PRO163E, PRO165E, SER10H, SER21H, VAL156E, VAL162E, VAL8H
• F-G: ALA3G, ALA4G, ARG55G, ASN51G, ASP139F, ASP2G, GLN54G, GLU11G, GLU5G, GLU7G, HIS102G, ILE50G, LEU48G, LEU9G, LYS141F, LYS144F, PHE8G, PRO142F, PRO143F, SER145F, TRP47G, VAL6G
• F-H: ALA12H, ALA16F, ALA39H, ALA4H, ALA59H, ALA6F, ALA73H, ALA78F, ALA89F, ARG11F, ARG15F, ARG42H, ARG55F, ARG65F, ARG71F, ARG73F, ARG74F, ARG7H, ARG82H, ARG83F, ARG86F, ARG88F, ARG91F, ASN18H, ASN43F, ASN58H, ASN72F, ASP23H, ASP24H, ASP46F, ASP57F, ASP57H, ASP78H, ASP82F, CYS3F, CYS67F, CYS75F, GLN122H, GLN177H, GLN193H, GLN20F, GLN42F, GLU12F, GLU16H, GLU170H, GLU17H, GLU18F, GLU30H, GLU3H, GLU49F, GLU4F, GLU67H, GLU8F, GLU93F, GLU9H, GLY11H, GLY174H, GLY19F, GLY44H, GLY75H, HIS115H, HIS14F, HIS29H, HIS66F, ILE10F, ILE25H, ILE59F, ILE62F, ILE83H, ILE87F, LEU13F, LEU20H, LEU22H, LEU26H, LEU39F, LEU43H, LEU58F, LEU66H, LEU68H, LEU69F, LEU70F, LEU70H, LEU72H, LEU76H, LEU80F, LEU84F, LEU84H, LEU85F, LEU90F, LEU9F, LYS141F, LYS144F, LYS181H, LYS31H, LYS5F, LYS63F, LYS74H, PHE19H, PHE2F, PHE46H, PHE47H, PHE64F, PHE6H, PHE77H, PRO142F, PRO17F, PRO41H, PRO60F, PRO69H, SER10H, SER21H, SER28H, SER45F, SER56F, SER68F, THR36H, THR38H, THR61F, THR76F, TRP113F, TRP71H, TRP92F, TYR117F, TYR5H, TYR79F, TYR81F, TYR94F, VAL34H, VAL47F, VAL60H, VAL77F, VAL8H
• G-H: ALA10G, ALA126G, ALA12H, ALA132G, ALA132H, ALA156H, ALA163G, ALA3G, ALA4G, ARG114G, ARG129G, ARG137G, ARG145H, ARG147H, ARG148H, ARG171G, ARG173H, ARG7H, ASN101G, ASN131H, ASN154G, ASN155H, ASN165G, ASN173G, ASN184H, ASN18H, ASP122G, ASP133G, ASP133H, ASP151H, ASP185H, ASP2G, CYS188H, GLN122H, GLN136H, GLN138G, GLN139G, GLN140H, GLN154H, GLN162G, GLN175G, GLN177H, GLN180H, GLN187H, GLN193H, GLU130H, GLU152G, GLU16H, GLU170H, GLU172H, GLU190H, GLU5G, GLU7G, GLU94G, GLU9H, GLY118H, GLY11H, GLY120H, GLY144H, GLY14H, GLY157G, GLY174H, GLY179H, GLY182H, GLY192H, HIS102G, HIS125H, HIS166G, ILE125G, ILE134H, ILE143H, ILE149H, LEU124H, LEU128G, LEU138H, LEU139H, LEU13H, LEU160G, LEU164G, LEU168H, LEU170G, LEU174G, LEU175H, LEU183H, LEU95G, LEU98G, LYS118G, LYS127G, LYS169G, LYS181H, LYS191H, LYS97G, PHE116H, PHE135G, PHE142H, PHE146H, PHE159G, PHE176H, PHE186H, PHE8G, PRO15H, SER10H, SER121H, SER128H, SER131G, SER134G, SER135H, SER137H, SER152H, SER153H, SER156G, THR141H, THR155G, THR158G, THR161G, THR172G, THR178H, THR96G, TRP121G, TRP189H, TYR117H, TYR168G, TYR91G, TYR92G, VAL130G, VAL136G, VAL6G
• G-K: ARG137G, ASP133G, LYS73K, VAL130G
• H-K: ALA102H, ALA163H, ARG147H, ARG148H, ARG167H, ARG59K, ARG97H, ASN105H, ASN106K, ASN158H, ASN20K, ASN37K, ASP103H, ASP108H, ASP151H, ASP160H, ASP67K, GLN93H, GLU112K, GLU159H, GLU43K, GLU64K, GLU69K, GLU87H, GLU94H, GLY39K, GLY95H, ILE107K, ILE17K, ILE18K, ILE91H, LEU164H, LEU40K, LEU60K, LEU61K, LEU71K, LEU88H, LYS109K, LYS111H, LYS70K, LYS73K, LYS90H, PHE100H, PRO104H, PRO108K, PRO19K, PRO38K, PRO41K, PRO62K, PRO63K, PRO89H, SER101H, THR161H, THR16K, THR98H, TRP65K, TRP96H, TYR92H, VAL106H, VAL107H, VAL42K, VAL68K, VAL99H
• I-J: ALA107J, ALA108J, ALA122J, ALA128I, ALA130I, ALA135I, ALA145I, ALA161I, ALA38J, ALA78J, ALA89J, ARG119J, ARG126J, ARG131I, ARG160I, ARG30J, ARG65J, ARG73J, ARG74J, ARG83J, ARG84I, ARG86I, ARG88J, ARG91J, ARG94I, ARG96I, ASN115J, ASN116J, ASN136I, ASN143I, ASN152I, ASN43J, ASN72J, ASP131J, ASP135J, ASP139J, ASP157I, ASP82J, CYS95I, GLN138J, GLN154I, GLN44J, GLU101I, GLU109J, GLU110J, GLU112J, GLU125I, GLU126I, GLU132I, GLU138I, GLU26J, GLU34J, GLU35J, GLU41J, GLU52I, GLU56I, GLU59I, GLU81I, GLU83I, GLY129J, GLY130J, HIS106I, HIS148I, HIS66J, ILE100I, ILE136J, ILE85I, ILE87J, LEU121J, LEU122I, LEU127I, LEU128J, LEU134J, LEU141I, LEU146I, LEU153I, LEU158I, LEU29J, LEU30I, LEU33J, LEU39J, LEU58I, LEU69J, LEU70J, LEU80J, LEU84J, LEU85J, LEU89I, LEU93I, LEU97I, LEU9J, LYS102I, LYS118J, LYS141J, LYS142I, LYS144J, LYS147I, LYS155I, LYS37J, LYS99I, PHE103I, PHE104I, PHE114J, PHE129I, PHE133I, PHE24J, PRO105I, PRO124I, PRO142J, PRO143J, PRO150I, PRO151I, PRO163I, SER120J, SER123I, SER127J, SER139I, SER145J, SER68J, SER76I, SER90I, SER91I, THR123J, THR137I, THR137J, THR76J, TRP113J, TRP34I, TRP92J, TYR117J, TYR124J, TYR140I, TYR40J, TYR79J, TYR81J, TYR87I, TYR92I, VAL144I, VAL156I, VAL162I, VAL32J, VAL51I, VAL54I, VAL77J, VAL88I
• I-K: ALA10K, ALA132K, ALA141K, ALA143K, ALA163K, ALA24I, ALA49K, ALA4K, ARG124K, ARG171K, ARG174I, ARG192I, ARG207I, ARG55K, ARG70I, ARG84I, ARG86I, ARG94I, ASN147K, ASN154K, ASN165K, ASN20K, ASN51K, ASN64I, ASP146K, ASP166I, ASP168I, ASP187I, ASP189I, ASP197I, ASP24K, ASP2K, ASP32K, ASP72I, CYS95I, GLN138K, GLN139K, GLN162K, GLN203I, GLN57I, GLN79I, GLU11K, GLU13K, GLU140K, GLU152K, GLU185I, GLU190I, GLU199I, GLU25I, GLU28I, GLU31I, GLU5K, GLU62I, GLU71I, GLU7K, GLU81I, GLU83I, GLY157K, GLY201I, GLY30K, GLY31K, HIS142K, HIS166K, HIS204I, HIS60I, HIS78I, ILE153K, ILE182I, ILE196I, ILE206I, ILE211I, ILE26K, ILE27I, ILE29K, ILE50K, ILE77I, ILE85I, LEU128K, LEU145K, LEU148K, LEU150K, LEU160K, LEU164K, LEU167I, LEU173I, LEU183I, LEU198I, LEU205I, LEU23K, LEU26I, LEU28K, LEU30I, LEU33K, LEU46K, LEU48K, LEU52K, LEU58I, LEU65I, LEU73I, LEU89I, LEU98K, LEU9K, LYS12K, LYS144K, LYS169K, LYS209I, LYS25K, LYS38I, LYS57K, LYS74I, PHE135K, PHE172I, PHE21K, PHE36K, PHE39I, PHE8K, PRO186I, PRO19K, PRO23I, PRO35K, PRO41I, PRO45K, PRO90K, SER169I, SER202I, SER22K, SER76I, SER91I, THR149K, THR158K, THR161K, THR172K, THR188I, THR210I, THR22I, TRP34I, TRP47K, TYR168K, TYR170I, TYR194I, TYR208I, TYR27K, TYR87I, TYR91K, VAL136K, VAL171I, VAL175I, VAL184I, VAL44K, VAL54I, VAL6K, VAL75I, VAL88I
• I-L: ALA161I, ALA4L, ARG160I, ARG7L, ARG94I, ASN18L, ASP157I, ASP166I, ASP187I, ASP189I, GLN136L, GLU101I, GLU17L, GLU9L, GLY11L, GLY14L, ILE100I, LEU139L, LEU141I, LEU146I, LEU158I, LEU20L, LEU97I, LYS102I, LYS164I, LYS99I, PHE103I, PHE104I, PHE133I, PHE19L, PHE6L, PRO105I, PRO163I, PRO165I, SER10L, SER169I, SER21L, THR137I, VAL156I, VAL162I, VAL8L
• J-K: ALA3K, ALA4K, ARG55K, ASN51K, ASP2K, GLN54K, GLU11K, GLU5K, GLU7K, HIS102K, ILE50K, LEU48K, LEU98K, LEU9K, LYS141J, LYS144J, LYS97K, PHE8K, PRO142J, PRO143J, SER145J, TRP47K, VAL6K
• J-L: ALA12L, ALA16J, ALA39L, ALA4L, ALA59L, ALA6J, ALA73L, ALA78J, ALA89J, ARG11J, ARG15J, ARG173L, ARG42L, ARG55J, ARG65J, ARG71J, ARG73J, ARG74J, ARG7L, ARG82L, ARG83J, ARG86J, ARG88J, ASN18L, ASN43J, ASN58L, ASN72J, ASP23L, ASP24L, ASP46J, ASP57J, ASP78L, ASP82J, CYS3J, CYS67J, CYS75J, GLN122L, GLN177L, GLN193L, GLN20J, GLN42J, GLU12J, GLU16L, GLU170L, GLU17L, GLU18J, GLU30L, GLU37L, GLU3L, GLU49J, GLU4J, GLU67L, GLU8J, GLU93J, GLU9L, GLY11L, GLY19J, GLY44L, GLY75L, HIS115L, HIS14J, HIS29L, HIS66J, ILE10J, ILE25L, ILE59J, ILE62J, ILE83L, ILE87J, LEU13J, LEU20L, LEU22L, LEU26L, LEU32L, LEU39J, LEU43L, LEU58J, LEU66L, LEU68L, LEU69J, LEU70J, LEU70L, LEU72L, LEU76L, LEU80J, LEU84J, LEU84L, LEU85J, LEU90J, LEU9J, LYS141J, LYS144J, LYS181L, LYS31L, LYS5J, LYS63J, LYS74L, PHE19L, PHE2J, PHE46L, PHE47L, PHE64J, PHE6L, PHE77L, PRO17J, PRO41L, PRO60J, PRO69L, SER10L, SER145J, SER21L, SER28L, SER45J, SER56J, SER68J, THR36L, THR38L, THR61J, THR76J, TRP71L, TRP92J, TYR117J, TYR5L, TYR79J, TYR81J, TYR94J, VAL47J, VAL60L, VAL77J, VAL8L
• K-L: ALA10K, ALA126K, ALA12L, ALA132K, ALA132L, ALA163K, ALA3K, ALA4K, ARG114K, ARG129K, ARG137K, ARG145L, ARG147L, ARG148L, ARG171K, ARG173L, ASN101K, ASN105L, ASN131L, ASN154K, ASN155L, ASN165K, ASN173K, ASN184L, ASN18L, ASP122K, ASP127L, ASP133K, ASP133L, ASP151L, ASP185L, ASP2K, CYS188L, GLN122L, GLN136L, GLN138K, GLN139K, GLN140L, GLN154L, GLN162K, GLN177L, GLN180L, GLN187L, GLN193L, GLN54K, GLU130L, GLU140K, GLU152K, GLU16L, GLU170L, GLU172L, GLU190L, GLU5K, GLU7K, GLU94K, GLU9L, GLY118L, GLY11L, GLY120L, GLY144L, GLY14L, GLY157K, GLY174L, GLY179L, GLY182L, GLY192L, HIS102K, HIS125L, HIS166K, ILE125K, ILE134L, ILE143L, ILE149L, ILE153K, ILE50K, LEU124L, LEU128K, LEU138L, LEU139L, LEU13L, LEU160K, LEU164K, LEU170K, LEU174K, LEU175L, LEU183L, LEU95K, LEU98K, LYS118K, LYS127K, LYS169K, LYS181L, LYS191L, LYS97K, PHE116L, PHE135K, PHE142L, PHE146L, PHE159K, PHE176L, PHE186L, PHE8K, PRO104L, PRO15L, SER10L, SER121L, SER128L, SER131K, SER134K, SER135L, SER137L, SER152L, SER153L, SER156K, THR141L, THR155K, THR158K, THR161K, THR172K, THR178L, THR96K, TRP121K, TRP189L, TYR117L, TYR168K, TYR91K, TYR92K, VAL117K, VAL130K, VAL136K, VAL6K