2E9X

the crystal structure of human gins core complex

• Total interactions analyzed: 28
• Total true interactions: 20
• Strongest Interaction:
  • Chains: F-H
  • Int. Res.: 168
  • Norm. En. per Res.: -4.889
• Hub Node: A(6)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	0.0	-2.0257	-16.1119	-18.1376	20	0	0	813	0	9	6
A-C	-50.5831	-49.1423	-502.195	-601.9204	140	24	15	19493	11	47	47
A-D	-33.9133	-21.1214	-446.991	-502.0257	156	18	13	18637	2	42	44
A-F	-6.282	57.8941	-122.641	-71.0289	66	4	2	4972	0	26	33
A-G	0.0	-11.0778	-4.7949	-15.8727	20	0	0	341	1	5	1
A-H	-6.9542	-29.8416	-14.4015	-51.1973	18	2	0	693	2	8	9
B-C	-35.5665	1.8678	-425.974	-459.6727	141	16	13	16749	1	37	33
B-D	-115.2731	-81.9689	-516.317	-713.559	164	23	13	21166	8	59	43
B-G	0.0	-10.9505	-4.3945	-15.3451	16	0	0	367	1	4	4
B-H	0.0	0.0	-0.0235	-0.0235	2	0	0	4	0	0	1
C-D	0.0	-8.2347	-51.7765	-60.0112	47	2	3	2467	0	17	12
C-F	0.0	0.0	-8.3426	-8.3426	17	8	0	809	0	1	2
C-G	0.0	0.0	-0.2733	-0.2733	7	0	0	75	0	1	0
C-H	-6.7209	-9.963	-62.2252	-78.9091	51	3	1	2882	1	23	19
E-F	0.0	-2.0583	-16.395	-18.4533	22	0	0	849	0	9	6
E-G	-50.4813	-46.6017	-460.271	-557.354	132	23	15	18144	8	45	42
E-H	-39.706	-27.1014	-457.572	-524.3794	158	12	12	18948	2	41	50
F-G	-12.7896	1.3286	-422.052	-433.5129	141	8	14	16581	1	34	33
F-H	-162.8328	-114.9013	-543.612	-821.3461	168	23	13	21490	9	60	46
G-H	0.0	-3.0378	-35.2829	-38.3207	39	0	3	1997	0	13	10

Interface residues

• A-B: ALA3B, ALA4B, ASN51B, ASP2B, GLN54B, GLU11B, GLU5B, GLU7B, HIS102B, ILE50B, LEU98B, LEU9B, LYS141A, LYS144A, MET140A, PHE8B, PRO142A, PRO143A, TRP47B, VAL6B
• A-C: ALA1004C, ALA1012C, ALA1039C, ALA1045C, ALA1059C, ALA1073C, ALA16A, ALA50A, ALA6A, ALA78A, ALA89A, ARG1007C, ARG1042C, ARG1082C, ARG1173C, ARG11A, ARG15A, ARG55A, ARG65A, ARG71A, ARG73A, ARG74A, ARG83A, ARG86A, ARG88A, ARG91A, ASN1018C, ASN43A, ASN48A, ASN72A, ASP1023C, ASP1024C, ASP1057C, ASP1078C, ASP46A, ASP57A, ASP82A, CYS3A, CYS67A, CYS75A, GLN1177C, GLN20A, GLN42A, GLU1003C, GLU1009C, GLU1016C, GLU1017C, GLU1030C, GLU1037C, GLU1170C, GLU12A, GLU18A, GLU35A, GLU49A, GLU4A, GLU8A, GLU93A, GLY1011C, GLY1044C, GLY1075C, GLY19A, GLY998C, HIS1000C, HIS1029C, HIS1115C, HIS14A, HIS66A, ILE1025C, ILE1083C, ILE10A, ILE59A, ILE62A, ILE87A, LEU1020C, LEU1022C, LEU1026C, LEU102A, LEU1043C, LEU1066C, LEU1068C, LEU1070C, LEU1072C, LEU1076C, LEU1084C, LEU13A, LEU21A, LEU39A, LEU58A, LEU69A, LEU70A, LEU80A, LEU84A, LEU85A, LEU90A, LEU9A, LYS1031C, LYS1074C, LYS141A, LYS63A, MET1001C, MET1027C, MET1040C, MET140A, MET1A, MET7A, PHE1006C, PHE1019C, PHE1046C, PHE1047C, PHE1077C, PHE2A, PHE64A, PRO1041C, PRO1069C, PRO1114C, PRO17A, PRO60A, PRO999C, SER1002C, SER1010C, SER1021C, SER1028C, SER45A, SER56A, SER68A, THR1036C, THR1038C, THR61A, THR76A, TRP1071C, TRP92A, TYR1005C, TYR117A, TYR79A, TYR81A, TYR94A, VAL1008C, VAL1060C, VAL47A, VAL77A
• A-D: ALA107A, ALA108A, ALA122A, ALA128D, ALA130D, ALA135D, ALA145D, ALA161D, ALA38A, ALA78A, ALA89A, ARG119A, ARG126A, ARG131D, ARG160D, ARG30A, ARG65A, ARG71A, ARG73A, ARG74A, ARG83A, ARG84D, ARG86D, ARG88A, ARG91A, ARG94D, ARG96D, ASN115A, ASN116A, ASN136D, ASN143D, ASN152D, ASN72A, ASP131A, ASP135A, ASP139A, ASP157D, ASP82A, CYS75A, CYS95D, GLN138A, GLN154D, GLN44A, GLN79D, GLU101D, GLU109A, GLU110A, GLU112A, GLU125D, GLU126D, GLU132D, GLU138D, GLU26A, GLU34A, GLU35A, GLU41A, GLU52D, GLU56D, GLU59D, GLU62D, GLU81D, GLU83D, GLY129A, GLY130A, GLY133A, HIS148D, HIS66A, ILE100D, ILE136A, ILE85D, ILE87A, LEU121A, LEU122D, LEU127D, LEU128A, LEU134A, LEU141D, LEU146D, LEU153D, LEU158D, LEU29A, LEU33A, LEU39A, LEU58D, LEU69A, LEU70A, LEU80A, LEU84A, LEU85A, LEU89D, LEU93D, LEU97D, LYS102D, LYS118A, LYS141A, LYS142D, LYS144A, LYS147D, LYS155D, LYS37A, LYS38D, LYS99D, MET106A, MET111A, MET125A, MET134D, MET140A, MET149D, MET36A, MET55D, MET80D, MET82D, MET98D, PHE103D, PHE104D, PHE114A, PHE129D, PHE133D, PHE24A, PRO105D, PRO124D, PRO142A, PRO143A, PRO150D, PRO151D, PRO163D, SER120A, SER123D, SER127A, SER139D, SER68A, SER90D, SER91D, THR123A, THR137A, THR137D, THR76A, TRP113A, TRP34D, TRP92A, TYR117A, TYR124A, TYR140D, TYR40A, TYR79A, TYR81A, TYR87D, TYR92D, VAL144D, VAL156D, VAL162D, VAL32A, VAL51D, VAL54D, VAL77A, VAL88D
• A-F: ALA101A, ALA107A, ALA108A, ALA132F, ALA141F, ALA143F, ALA16A, ALA23A, ARG103A, ARG129F, ARG137F, ARG15A, ARG171F, ARG30A, ARG79F, ARG83A, ARG86A, ASN100A, ASN25A, ASP133F, ASP146F, ASP27A, GLN138F, GLN139F, GLN20A, GLN31A, GLU110A, GLU12A, GLU140F, GLU18A, GLU26A, GLU78F, GLU81F, GLU82F, GLU93A, GLY19A, GLY28A, HIS105A, HIS142F, HIS77F, LEU102A, LEU128F, LEU21A, LEU90A, LEU98A, LYS127F, LYS141A, LYS144F, LYS80F, MET106A, PHE104A, PHE135F, PHE24A, PHE84F, PRO17A, PRO22A, PRO99A, SER131F, SER134F, THR123F, THR83F, THR85F, TYR94A, VAL130F, VAL136F, VAL97A
• A-G: ALA101A, ALA132G, ARG147G, ARG97G, ASN100A, ASN131G, ASP133G, GLN136G, GLN140G, GLU130G, GLU93A, GLY144G, ILE134G, ILE143G, LYS141A, LYS144A, PHE104A, PRO129G, PRO99A, TYR94A
• A-H: ALA16A, ARG15A, ARG192H, ASP187H, ASP189H, ASP193H, ASP197H, GLN191H, GLN20A, GLU18A, GLU199H, HIS204H, ILE196H, PRO17A, PRO186H, TYR194H, VAL184H, VAL195H
• B-C: ALA1012C, ALA10B, ALA1132C, ALA1156C, ALA126B, ALA132B, ALA163B, ALA3B, ALA4B, ARG1007C, ARG1145C, ARG1147C, ARG1148C, ARG114B, ARG129B, ARG137B, ARG171B, ASN1018C, ASN101B, ASN1131C, ASN1155C, ASN1158C, ASN1184C, ASN154B, ASN165B, ASN173B, ASP1127C, ASP1133C, ASP1151C, ASP1185C, ASP122B, ASP133B, ASP2B, CYS1188C, GLN1122C, GLN1136C, GLN1140C, GLN1154C, GLN1177C, GLN1180C, GLN1187C, GLN138B, GLN139B, GLN162B, GLN175B, GLU1003C, GLU1009C, GLU1016C, GLU1130C, GLU1170C, GLU1172C, GLU1190C, GLU11B, GLU140B, GLU152B, GLU5B, GLU7B, GLU94B, GLY1011C, GLY1014C, GLY1118C, GLY1120C, GLY1144C, GLY1174C, GLY1179C, GLY1182C, GLY1192C, GLY157B, HIS102B, HIS1125C, HIS166B, ILE1134C, ILE1143C, ILE1149C, ILE125B, LEU100B, LEU1013C, LEU1123C, LEU1124C, LEU1138C, LEU1139C, LEU1168C, LEU1175C, LEU1183C, LEU128B, LEU160B, LEU164B, LEU170B, LEU174B, LEU95B, LEU98B, LYS1181C, LYS118B, LYS1191C, LYS127B, LYS169B, LYS97B, MET1150C, MET1171C, MET151B, MET167B, MET1B, MET93B, PHE1116C, PHE1142C, PHE1146C, PHE1176C, PHE1186C, PHE135B, PHE159B, PHE8B, PRO1015C, PRO1104C, SER1010C, SER1121C, SER1128C, SER1135C, SER1137C, SER1152C, SER1153C, SER131B, SER134B, SER156B, THR1141C, THR1178C, THR155B, THR158B, THR161B, THR172B, THR96B, TRP1189C, TRP121B, TYR1117C, TYR1157C, TYR168B, TYR91B, TYR92B, VAL117B, VAL130B, VAL136B, VAL6B
• B-D: ALA10B, ALA132B, ALA141B, ALA143B, ALA163B, ALA24D, ALA4B, ARG124B, ARG171B, ARG174D, ARG192D, ARG207D, ARG55B, ARG84D, ARG86D, ARG94D, ASN147B, ASN154B, ASN165B, ASN173B, ASN51B, ASP146B, ASP166D, ASP168D, ASP187D, ASP189D, ASP193D, ASP197D, ASP24B, ASP2B, ASP32B, ASP72D, CYS53D, GLN138B, GLN139B, GLN162B, GLN175B, GLN203D, GLN221D, GLN32D, GLN54B, GLN57D, GLN79D, GLU11B, GLU13B, GLU140B, GLU152B, GLU185D, GLU190D, GLU199D, GLU25D, GLU28D, GLU31D, GLU56D, GLU5B, GLU71D, GLU7B, GLU81D, GLU83D, GLY157B, GLY201D, GLY30B, GLY31B, HIS142B, HIS166B, HIS204D, HIS60D, HIS78D, ILE153B, ILE182D, ILE196D, ILE206D, ILE211D, ILE223D, ILE26B, ILE27D, ILE29B, ILE77D, ILE85D, LEU128B, LEU145B, LEU148B, LEU150B, LEU160B, LEU164B, LEU167D, LEU173D, LEU174B, LEU183D, LEU198D, LEU205D, LEU222D, LEU23B, LEU26D, LEU28B, LEU30D, LEU33B, LEU46B, LEU48B, LEU52B, LEU58D, LEU73D, LEU89D, LEU9B, LYS12B, LYS144B, LYS169B, LYS209D, LYS25B, LYS38D, LYS57B, LYS74D, MET167B, MET1B, MET35D, MET61D, MET80D, MET82D, PHE135B, PHE159B, PHE172D, PHE21B, PHE36B, PHE39D, PHE84B, PHE8B, PRO186D, PRO19B, PRO23D, PRO35B, PRO41D, PRO45B, PRO90B, SER156B, SER169D, SER202D, SER22B, SER76D, SER91D, THR149B, THR158B, THR161B, THR172B, THR188D, THR210D, THR22D, TRP34D, TRP47B, TYR168B, TYR170D, TYR194D, TYR208D, TYR27B, TYR87D, TYR91B, VAL136B, VAL171D, VAL175D, VAL184D, VAL44B, VAL54D, VAL6B, VAL75D, VAL88D
• B-G: ALA103B, ARG35G, ARG59B, ARG81G, ASN101B, ASN106B, ASP105B, GLN54B, GLN56B, GLU37G, HIS102B, LEU100B, LYS53B, LYS80G, PRO129G, SER104B
• B-H: ASP2B, GLN191H
• C-D: ALA1004C, ALA161D, ARG1007C, ARG160D, ARG94D, ASN1018C, ASP157D, ASP166D, ASP187D, CYS95D, GLU1003C, GLU1009C, GLU1017C, GLU101D, GLY1011C, HIS106D, ILE100D, LEU1020C, LEU1139C, LEU141D, LEU146D, LEU158D, LEU97D, LYS102D, LYS164D, LYS38D, LYS99D, MET149D, MET98D, PHE1006C, PHE1019C, PHE103D, PHE104D, PHE129D, PHE133D, PRO1015C, PRO105D, PRO163D, SER1010C, SER1021C, SER91D, THR137D, THR188D, TYR1005C, VAL1008C, VAL156D, VAL162D
• C-F: ARG137F, ARG171F, CYS1188C, GLN138F, GLN139F, GLN175F, GLU140F, GLY1192C, GLY998C, HIS1000C, LEU174F, LYS1191C, MET1001C, PHE135F, PRO999C, SER134F, VAL136F
• C-G: GLN136G, GLN140G, GLY998C, HIS1000C, ILE143G, LEU139G, PRO999C
• C-H: ALA1163C, ALA1166C, ARG1167C, ARG1173C, ARG178H, ARG192H, ASN1155C, ASN1184C, ASN181H, ASP1108C, ASP1160C, ASP1185C, ASP187H, ASP189H, ASP193H, ASP197H, CYS1188C, GLN1177C, GLN1180C, GLN1187C, GLN191H, GLU1170C, GLU180H, GLU190H, GLY1182C, GLY998C, HIS1000C, HIS1110C, ILE182H, ILE196H, LEU1168C, LEU1183C, LEU183H, LYS1111C, LYS1181C, LYS1191C, MET1001C, PHE1176C, PHE1186C, PRO1114C, PRO186H, PRO999C, SER1002C, SER1153C, SER1162C, THR1161C, THR1178C, THR188H, TYR194H, VAL1165C, VAL195H
• E-F: ALA3F, ALA4F, ASN51F, ASP2F, GLN54F, GLU11F, GLU5F, GLU7F, HIS102F, ILE50F, LEU98F, LEU9F, LYS141E, LYS144E, LYS97F, MET140E, MET1F, PHE8F, PRO142E, PRO143E, TRP47F, VAL6F
• E-G: ALA12G, ALA16E, ALA39G, ALA45G, ALA4G, ALA59G, ALA6E, ALA73G, ALA78E, ALA89E, ARG11E, ARG15E, ARG42G, ARG55E, ARG65E, ARG71E, ARG73E, ARG74E, ARG7G, ARG82G, ARG83E, ARG86E, ARG88E, ARG91E, ASN18G, ASN43E, ASN72E, ASP23G, ASP24G, ASP46E, ASP57E, ASP57G, ASP78G, ASP82E, CYS3E, CYS67E, CYS75E, GLN20E, GLN42E, GLU12E, GLU16G, GLU170G, GLU17G, GLU18E, GLU30G, GLU35E, GLU37G, GLU3G, GLU49E, GLU4E, GLU67G, GLU8E, GLU93E, GLU9G, GLY11G, GLY19E, GLY44G, GLY75G, HIS115G, HIS14E, HIS29G, HIS66E, ILE10E, ILE25G, ILE59E, ILE62E, ILE83G, ILE87E, LEU13E, LEU20G, LEU22G, LEU26G, LEU39E, LEU43G, LEU58E, LEU66G, LEU68G, LEU69E, LEU70E, LEU70G, LEU72G, LEU76G, LEU80E, LEU84E, LEU84G, LEU85E, LEU90E, LEU9E, LYS141E, LYS31G, LYS63E, LYS74G, MET140E, MET1E, MET1G, MET27G, MET40G, MET7E, PHE19G, PHE2E, PHE46G, PHE47G, PHE64E, PHE6G, PHE77G, PRO142E, PRO17E, PRO41G, PRO60E, PRO69G, SER10G, SER21G, SER28G, SER2G, SER45E, SER56E, SER68E, THR36G, THR38G, THR61E, THR76E, TRP189G, TRP71G, TRP92E, TYR117E, TYR5G, TYR79E, TYR81E, TYR94E, VAL60G, VAL77E, VAL8G
• E-H: ALA107E, ALA108E, ALA122E, ALA128H, ALA130H, ALA135H, ALA145H, ALA161H, ALA38E, ALA78E, ALA89E, ARG119E, ARG126E, ARG160H, ARG30E, ARG65E, ARG71E, ARG73E, ARG74E, ARG83E, ARG84H, ARG86H, ARG88E, ARG91E, ARG94H, ARG96H, ASN115E, ASN116E, ASN136H, ASN143H, ASN152H, ASN43E, ASN72E, ASP131E, ASP135E, ASP139E, ASP157H, ASP82E, CYS75E, CYS95H, GLN138E, GLN154H, GLN44E, GLN79H, GLU101H, GLU109E, GLU110E, GLU112E, GLU125H, GLU126H, GLU132E, GLU132H, GLU138H, GLU26E, GLU34E, GLU35E, GLU41E, GLU52H, GLU56H, GLU59H, GLU62H, GLU81H, GLU83H, GLY129E, GLY130E, GLY133E, HIS148H, HIS66E, ILE100H, ILE136E, ILE85H, ILE87E, LEU121E, LEU122H, LEU127H, LEU128E, LEU134E, LEU141H, LEU146H, LEU153H, LEU158H, LEU29E, LEU33E, LEU39E, LEU58H, LEU69E, LEU70E, LEU80E, LEU84E, LEU85E, LEU89H, LEU93H, LEU97H, LYS102H, LYS118E, LYS141E, LYS142H, LYS144E, LYS147H, LYS155H, LYS37E, LYS38H, LYS99H, MET106E, MET111E, MET125E, MET134H, MET140E, MET149H, MET36E, MET55H, MET80H, MET82H, MET98H, PHE103H, PHE104H, PHE114E, PHE129H, PHE133H, PHE24E, PRO105H, PRO124H, PRO142E, PRO143E, PRO150H, PRO151H, PRO163H, SER120E, SER123H, SER127E, SER139H, SER46H, SER68E, SER90H, SER91H, THR123E, THR137E, THR137H, THR76E, TRP113E, TRP34H, TRP92E, TYR117E, TYR124E, TYR140H, TYR40E, TYR79E, TYR81E, TYR87H, TYR92H, VAL144H, VAL156H, VAL162H, VAL32E, VAL51H, VAL54H, VAL77E, VAL88H
• F-G: ALA10F, ALA126F, ALA12G, ALA132F, ALA132G, ALA156G, ALA163F, ALA3F, ALA4F, ARG114F, ARG129F, ARG137F, ARG145G, ARG147G, ARG148G, ARG171F, ARG173G, ASN101F, ASN105G, ASN131G, ASN154F, ASN155G, ASN158G, ASN165F, ASN173F, ASN184G, ASN18G, ASP103G, ASP122F, ASP127G, ASP133F, ASP133G, ASP151G, ASP185G, ASP2F, CYS188G, GLN122G, GLN136G, GLN138F, GLN139F, GLN140G, GLN154G, GLN162F, GLN175F, GLN177G, GLN180G, GLN187G, GLU11F, GLU130G, GLU152F, GLU16G, GLU170G, GLU172G, GLU190G, GLU3G, GLU5F, GLU7F, GLU94F, GLU9G, GLY118G, GLY11G, GLY120G, GLY144G, GLY14G, GLY157F, GLY174G, GLY179G, GLY182G, GLY192G, HIS102F, HIS125G, HIS166F, ILE125F, ILE134G, ILE143G, ILE149G, LEU124G, LEU128F, LEU138G, LEU139G, LEU13G, LEU160F, LEU164F, LEU168G, LEU170F, LEU174F, LEU175G, LEU183G, LEU46F, LEU95F, LEU98F, LYS118F, LYS127F, LYS169F, LYS181G, LYS191G, LYS97F, MET150G, MET151F, MET167F, MET171G, MET1F, MET93F, PHE116G, PHE135F, PHE142G, PHE146G, PHE159F, PHE176G, PHE186G, PHE8F, PRO104G, PRO15G, SER10G, SER121G, SER128G, SER131F, SER134F, SER135G, SER137G, SER152G, SER153G, SER156F, THR141G, THR155F, THR158F, THR161F, THR172F, THR178G, THR96F, TRP121F, TRP189G, TYR117G, TYR157G, TYR168F, TYR91F, TYR92F, VAL117F, VAL130F, VAL136F, VAL6F
• F-H: ALA10F, ALA132F, ALA141F, ALA143F, ALA163F, ALA24H, ALA49F, ALA4F, ARG171F, ARG174H, ARG192H, ARG207H, ARG55F, ARG84H, ARG86H, ARG94H, ASN147F, ASN154F, ASN165F, ASN173F, ASN51F, ASP146F, ASP166H, ASP168H, ASP187H, ASP189H, ASP193H, ASP197H, ASP24F, ASP2F, ASP32F, ASP72H, CYS53H, GLN138F, GLN139F, GLN162F, GLN175F, GLN203H, GLN221H, GLN32H, GLN54F, GLN57H, GLN79H, GLU11F, GLU13F, GLU140F, GLU152F, GLU185H, GLU190H, GLU199H, GLU25H, GLU28H, GLU31H, GLU56H, GLU59H, GLU5F, GLU62H, GLU71H, GLU7F, GLU81H, GLU83H, GLY157F, GLY201H, GLY30F, GLY31F, GLY34F, HIS142F, HIS166F, HIS204H, HIS60H, HIS78H, ILE153F, ILE182H, ILE196H, ILE206H, ILE211H, ILE223H, ILE26F, ILE27H, ILE29F, ILE50F, ILE77H, ILE85H, LEU128F, LEU145F, LEU148F, LEU150F, LEU160F, LEU164F, LEU167H, LEU173H, LEU174F, LEU198H, LEU205H, LEU222H, LEU23F, LEU26H, LEU28F, LEU30H, LEU33F, LEU46F, LEU48F, LEU52F, LEU58H, LEU73H, LEU89H, LEU98F, LEU9F, LYS12F, LYS144F, LYS169F, LYS209H, LYS25F, LYS38H, LYS57F, LYS74H, MET167F, MET1F, MET35H, MET61H, MET80H, MET82H, PHE135F, PHE159F, PHE172H, PHE21F, PHE36F, PHE39H, PHE8F, PRO165H, PRO186H, PRO23H, PRO35F, PRO41H, PRO45F, PRO90F, SER131F, SER156F, SER169H, SER202H, SER22F, SER76H, SER91H, THR149F, THR158F, THR161F, THR172F, THR188H, THR210H, THR22H, TRP34H, TRP47F, TYR168F, TYR170H, TYR194H, TYR208H, TYR27F, TYR87H, TYR91F, VAL136F, VAL171H, VAL175H, VAL184H, VAL44F, VAL54H, VAL6F, VAL75H, VAL88H
• G-H: ALA161H, ALA4G, ARG160H, ARG192H, ARG7G, ARG94H, ASN18G, ASP157H, ASP166H, CYS95H, GLU101H, GLU16G, GLU17G, GLU3G, GLU9G, GLY11G, GLY14G, LEU139G, LEU141H, LEU146H, LEU158H, LEU20G, LYS102H, LYS164H, MET149H, MET98H, PHE103H, PHE104H, PHE19G, PHE6G, PRO105H, PRO15G, PRO163H, SER10G, SER21G, THR137H, VAL156H, VAL162H, VAL8G