2E9W

crystal structure of the extracellular domain of kit in complex with stem cell factor (scf)

• Total interactions analyzed: 6
• Total true interactions: 4
• Strongest Interaction:
  • Chains: C-D
  • Int. Res.: 66
  • Norm. En. per Res.: -3.943
• Hub Node: A(2)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-8.4059	1.4109	-37.6306	-44.6256	53	1	0	1678	3	21	21
A-C	-64.6947	-127.34	-160.81	-352.8447	94	17	0	7802	7	70	38
B-D	-53.7563	-128.3111	-188.311	-370.3784	96	12	0	7882	7	76	46
C-D	-30.3657	-6.9504	-222.923	-260.2391	66	17	5	8405	1	13	12

Interface residues

• A-B: ALA502A, ALA502B, ARG381A, ARG381B, ARG420A, ARG420B, ASN330A, ASN330B, ASN505A, ASN505B, ASP327A, GLU329A, GLU329B, GLU386A, GLU386B, GLU414B, GLU490A, GLU490B, GLY328A, GLY328B, GLY384A, GLY384B, GLY445A, GLY445B, LEU379A, LEU379B, LEU382A, LEU382B, LYS358A, LYS358B, LYS383A, LYS383B, LYS412A, PHE355A, PHE355B, PHE504A, PHE504B, SER501A, SER501B, THR356A, THR356B, THR380A, THR380B, THR385A, THR385B, THR488A, THR488B, TYR390A, TYR390B, TYR418A, TYR418B, TYR503A, TYR503B
• A-C: ARG122A, ARG135A, ARG181A, ARG205A, ARG271A, ARG5C, ARG7C, ASN10C, ASN11C, ASN260A, ASN268A, ASN6C, ASN75A, ASN81C, ASP121A, ASP14C, ASP266A, ASP54C, ASP58C, ASP61C, ASP72A, ASP77C, ASP84C, ASP85C, CYS183A, CYS4C, CYS89C, GLN272A, GLN51C, GLU270A, GLU73A, GLU88C, GLU92C, GLY126A, GLY265A, HIS180A, HIS263A, HIS264A, ILE201A, ILE76C, ILE82C, LEU124A, LEU52C, LEU56C, LEU60C, LEU71A, LEU79C, LEU86C, LYS100C, LYS103C, LYS127A, LYS127C, LYS13C, LYS199A, LYS203A, LYS258A, LYS31C, LYS78C, LYS91C, PHE102C, PHE200A, PHE208A, PHE267A, PRO206A, SER101C, SER104C, SER123A, SER239A, SER240A, SER241A, SER244A, SER261A, SER53C, SER55C, SER74C, THR57C, THR74A, THR9C, TRP262A, TYR125A, TYR243A, TYR259A, TYR269A, TYR73C, VAL120A, VAL12C, VAL238A, VAL242A, VAL49C, VAL50C, VAL80C, VAL83C, VAL87C, VAL8C
• B-D: ARG122B, ARG135B, ARG181B, ARG205B, ARG271B, ARG5D, ARG7D, ASN10D, ASN11D, ASN260B, ASN268B, ASN6D, ASN75B, ASN81D, ASP121B, ASP14D, ASP266B, ASP54D, ASP58D, ASP61D, ASP72B, ASP77D, ASP84D, ASP85D, ASP97D, CYS183B, CYS4D, CYS89D, GLN272B, GLN51D, GLU257B, GLU270B, GLU69B, GLU73B, GLU88D, GLU92D, GLY126B, GLY265B, HIS180B, HIS263B, HIS264B, ILE201B, ILE70B, ILE76D, ILE82D, LEU124B, LEU52D, LEU56D, LEU60D, LEU71B, LEU79D, LEU86D, LEU98D, LYS100D, LYS103D, LYS127B, LYS127D, LYS13D, LYS199B, LYS203B, LYS31D, LYS78D, LYS91D, LYS99D, PHE102D, PHE200B, PHE267B, PRO206B, SER101D, SER104D, SER123B, SER239B, SER240B, SER241B, SER244B, SER261B, SER53D, SER55D, SER74D, THR57D, THR74B, THR9D, TRP262B, TYR125B, TYR243B, TYR259B, TYR269B, TYR73D, VAL12D, VAL242B, VAL49D, VAL50D, VAL80D, VAL83D, VAL87D, VAL8D
• C-D: ALA20C, ALA20D, ASN21C, ASN21D, ASN65C, ASN65D, ASN72C, ASN72D, ASP25C, ASP25D, ASP58D, ASP61C, ASP61D, GLU68C, GLU68D, GLY69C, GLY69D, ILE28C, ILE28D, ILE66C, ILE66D, ILE75C, ILE75D, ILE76C, ILE76D, LEU18C, LEU18D, LEU22C, LEU22D, LEU59C, LEU59D, LEU60C, LEU60D, LEU70C, LEU70D, LYS17C, LYS17D, LYS24C, LYS24D, LYS62C, LYS62D, MET27C, MET27D, PHE63C, PHE63D, PRO112C, PRO112D, PRO23C, PRO23D, SER64C, SER64D, SER67C, SER67D, SER71C, SER71D, SER74C, SER74D, THR16C, THR16D, TYR26C, TYR26D, TYR73C, TYR73D, VAL15D, VAL19C, VAL19D