2E7A

tnf receptor subtype one-selective tnf mutant with antagonistic activity

• Total interactions analyzed: 3
• Total true interactions: 3
• Strongest Interaction:
  • Chains: B-C
  • Int. Res.: 109
  • Norm. En. per Res.: -3.3779
• Hub Node: A(2)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-39.1229	-34.1852	-266.434	-339.7421	111	6	11	11332	3	9	7
A-C	-38.5603	-19.314	-290.024	-347.8983	116	9	12	12101	1	8	8
B-C	-35.8391	-33.0665	-299.287	-368.1926	109	13	11	12280	4	8	6

Interface residues

• A-B: ALA109A, ALA111A, ALA145A, ALA14A, ALA156A, ALA33A, ALA35A, ALA38A, ALA96B, ARG103A, ARG32A, ARG82B, ARG98A, ARG98B, ASN112A, ASN34A, ASN39A, ASN92B, ASP10A, ASP130B, ASP143A, CYS101A, GLN102B, GLN125B, GLN149A, GLN61A, GLN67A, GLU110A, GLU116A, GLU116B, GLU146A, GLU53B, GLY121A, GLY121B, GLY122B, GLY148A, GLY153A, GLY54B, GLY66A, GLY68A, HIS15A, HIS73B, HIS78B, HIS87B, ILE118A, ILE118B, ILE154A, ILE155A, ILE155B, ILE58A, ILE58B, ILE80B, ILE97B, LEU120A, LEU120B, LEU126B, LEU157A, LEU157B, LEU36A, LEU37A, LEU55B, LEU57A, LEU57B, LEU63A, LEU75B, LEU76A, LEU76B, LEU93B, LEU94B, MET11A, MET11B, PHE124B, PHE152A, PHE64A, PRO100A, PRO100B, PRO113A, PRO117A, PRO117B, PRO12A, PRO8A, PRO90B, SER147A, SER60A, SER60B, SER65A, SER71B, SER84B, SER95B, SER99A, SER99B, SER9A, THR72B, THR77B, THR79B, TRP114A, TYR115A, TYR115B, TYR119A, TYR119B, TYR151A, TYR56B, TYR59A, TYR59B, VAL123B, VAL13A, VAL150A, VAL17A, VAL62A, VAL74B, VAL91B
• A-C: ALA111C, ALA145C, ALA14C, ALA156C, ALA33C, ALA35C, ALA38C, ALA96A, ARG103A, ARG103C, ARG32C, ARG82A, ARG98A, ARG98C, ASN112C, ASN34C, ASN39C, ASN92A, ASP10C, ASP143C, CYS101A, CYS101C, CYS69A, CYS69C, GLN102A, GLN102C, GLN125A, GLN149C, GLN61C, GLN67C, GLN89A, GLU104A, GLU116A, GLU116C, GLU146C, GLU53A, GLY121A, GLY121C, GLY122A, GLY148C, GLY153C, GLY54A, GLY66C, GLY68C, HIS15C, HIS73A, HIS78A, HIS87A, ILE118A, ILE118C, ILE154C, ILE155A, ILE155C, ILE58A, ILE58C, ILE80A, ILE97A, LEU120A, LEU120C, LEU126A, LEU157A, LEU157C, LEU36C, LEU37C, LEU55A, LEU57A, LEU57C, LEU63C, LEU75A, LEU76A, LEU93A, LEU94A, MET11A, MET11C, PHE124A, PHE152C, PHE64C, PRO100A, PRO100C, PRO113C, PRO117A, PRO117C, PRO12C, PRO70A, PRO70C, PRO8C, PRO90A, SER147C, SER60A, SER60C, SER65C, SER71A, SER81A, SER84A, SER95A, SER99A, SER99C, SER9C, THR72A, THR77A, THR79A, TRP114C, TYR115C, TYR119A, TYR119C, TYR151C, TYR56A, TYR59A, TYR59C, VAL123A, VAL13C, VAL150C, VAL17C, VAL62C, VAL74A, VAL91A
• B-C: ALA111B, ALA145B, ALA14B, ALA156B, ALA156C, ALA33B, ALA35B, ALA38B, ALA96C, ARG103C, ARG82C, ARG98B, ARG98C, ASN112B, ASN34B, ASN39B, ASN92C, ASP10B, ASP143B, CYS101B, CYS101C, CYS69B, GLN102B, GLN102C, GLN125C, GLN149B, GLN61B, GLU116B, GLU116C, GLU127C, GLU146B, GLU53C, GLY121B, GLY121C, GLY122C, GLY148B, GLY153B, GLY54C, GLY66B, GLY68B, HIS15B, HIS73C, HIS78C, ILE118B, ILE118C, ILE154B, ILE155B, ILE155C, ILE58B, ILE58C, ILE80C, ILE97C, LEU120B, LEU120C, LEU126C, LEU157B, LEU157C, LEU36B, LEU55C, LEU57B, LEU57C, LEU63B, LEU75C, LEU76B, LEU76C, LEU93C, LEU94C, MET11B, PHE124C, PHE152B, PHE64B, PRO100B, PRO100C, PRO113B, PRO117B, PRO117C, PRO12B, PRO70B, PRO8B, PRO90C, SER147B, SER60B, SER60C, SER65B, SER71C, SER81C, SER84C, SER95C, SER99B, SER99C, SER9B, THR72C, THR77C, THR79C, TRP114B, TYR115B, TYR119B, TYR119C, TYR151B, TYR56C, TYR59B, TYR59C, VAL123C, VAL13B, VAL150B, VAL17B, VAL62B, VAL74C, VAL91C