2E77

crystal structure of l-lactate oxidase with pyruvate complex

• Total interactions analyzed: 6
• Total true interactions: 6
• Strongest Interaction:
  • Chains: A-D
  • Int. Res.: 150
  • Norm. En. per Res.: -5.7239
• Hub Node: A(3)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	0.0	6.1222	-0.1734	5.9488	4	0	0	37	0	5	1
A-C	-128.6417	-154.548	-565.841	-849.0308	151	25	16	19939	12	66	57
A-D	-130.0521	-157.8066	-570.732	-858.5907	150	24	16	20239	12	66	58
B-C	-130.2825	-146.0396	-574.195	-850.5171	151	20	15	20191	10	68	58
B-D	-106.4049	-154.717	-568.777	-829.8989	151	23	17	20133	12	69	57
C-D	0.0	6.5067	-0.2035	6.3032	5	0	0	40	0	6	1

Interface residues

• A-B: ARG1052B, ARG52A, GLU1373B, GLU373A
• A-C: ALA2053C, ALA2057C, ALA2173C, ALA2249C, ALA2252C, ALA2273C, ALA2282C, ALA306A, ALA57A, ALA68A, ALA73A, ARG2052C, ARG2056C, ARG2181C, ARG2183C, ARG2225C, ARG2255C, ARG2268C, ARG2286C, ARG300A, ARG301A, ARG347A, ARG56A, ARG66A, ASN2054C, ASN2180C, ASN2187C, ASN21A, ASN2264C, ASN2368C, ASN368A, ASP18A, ASP2047C, ASP2055C, ASP2174C, ASP2182C, ASP2184C, ASP2226C, ASP2248C, ASP2250C, ASP2278C, ASP2367C, ASP24A, ASP344A, ASP364A, ASP367A, ASP55A, ASP70A, GLN2220C, GLN2244C, GLN2269C, GLN350A, GLN355A, GLN69A, GLU2048C, GLU2228C, GLU2247C, GLU2272C, GLU2373C, GLU28A, GLU303A, GLU373A, GLU72A, GLY2046C, GLY2179C, GLY2242C, GLY2275C, GLY2371C, GLY302A, GLY353A, GLY371A, HIS2060C, HIS2245C, HIS2265C, HIS304A, HIS60A, ILE2222C, ILE2227C, ILE2243C, ILE2260C, ILE2283C, LEU2171C, LEU2270C, LEU2280C, LEU351A, LEU363A, LEU365A, LEU62A, LEU63A, LEU67A, LYS2059C, LYS2061C, LYS2149C, LYS2186C, LYS2188C, LYS2219C, LYS2221C, LYS2241C, LYS307A, LYS343A, LYS59A, LYS61A, MET2147C, MET2251C, MET349A, PHE2277C, PHE366A, PRO2224C, PRO2246C, PRO2274C, PRO2281C, PRO2369C, PRO369A, PRO65A, PRO74A, SER2045C, SER2175C, SER2178C, SER2218C, SER2223C, SER2263C, SER2276C, THR2050C, THR2172C, THR2176C, THR2279C, THR346A, THR352A, TRP2049C, TRP2058C, TRP2261C, TRP58A, TYR2215C, TYR2271C, TYR2370C, TYR2372C, TYR2374C, TYR23A, TYR340A, TYR370A, TYR372A, TYR374A, TYR64A, VAL19A, VAL20A, VAL2177C, VAL2185C, VAL2240C, VAL2262C, VAL348A, VAL71A
• A-D: ALA173A, ALA249A, ALA252A, ALA273A, ALA282A, ALA3057D, ALA3068D, ALA3073D, ALA3306D, ALA53A, ALA57A, ARG181A, ARG183A, ARG225A, ARG255A, ARG268A, ARG286A, ARG3056D, ARG3066D, ARG3300D, ARG3301D, ARG3347D, ARG52A, ARG56A, ASN180A, ASN187A, ASN264A, ASN3021D, ASN3368D, ASN368A, ASN54A, ASP174A, ASP182A, ASP184A, ASP226A, ASP248A, ASP250A, ASP278A, ASP3018D, ASP3024D, ASP3055D, ASP3070D, ASP3344D, ASP3364D, ASP3367D, ASP367A, ASP47A, ASP55A, GLN220A, GLN244A, GLN269A, GLN3069D, GLN3350D, GLN3355D, GLU228A, GLU247A, GLU272A, GLU3028D, GLU3072D, GLU3303D, GLU3373D, GLU373A, GLU48A, GLY179A, GLY242A, GLY275A, GLY3302D, GLY3353D, GLY3371D, GLY371A, GLY46A, HIS245A, HIS265A, HIS3060D, HIS3304D, HIS60A, ILE222A, ILE227A, ILE243A, ILE260A, ILE283A, LEU171A, LEU270A, LEU280A, LEU3062D, LEU3063D, LEU3067D, LEU3351D, LEU3363D, LEU3365D, LYS149A, LYS186A, LYS188A, LYS219A, LYS221A, LYS241A, LYS3059D, LYS3061D, LYS3307D, LYS3343D, LYS59A, LYS61A, MET251A, MET3349D, PHE277A, PHE3366D, PRO224A, PRO246A, PRO274A, PRO281A, PRO3065D, PRO3074D, PRO3369D, PRO369A, SER175A, SER178A, SER218A, SER223A, SER263A, SER276A, SER45A, THR172A, THR176A, THR279A, THR3346D, THR3352D, THR50A, TRP261A, TRP3058D, TRP49A, TRP58A, TYR215A, TYR271A, TYR3023D, TYR3064D, TYR3340D, TYR3370D, TYR3372D, TYR3374D, TYR370A, TYR372A, TYR374A, VAL177A, VAL185A, VAL240A, VAL262A, VAL3019D, VAL3020D, VAL3071D, VAL3348D
• B-C: ALA1053B, ALA1057B, ALA1173B, ALA1249B, ALA1252B, ALA1267B, ALA1273B, ALA1282B, ALA2057C, ALA2068C, ALA2073C, ALA2306C, ARG1052B, ARG1056B, ARG1181B, ARG1183B, ARG1225B, ARG1255B, ARG1268B, ARG1286B, ARG2056C, ARG2066C, ARG2300C, ARG2301C, ARG2347C, ASN1054B, ASN1180B, ASN1187B, ASN1212B, ASN1264B, ASN1368B, ASN2021C, ASN2368C, ASP1047B, ASP1055B, ASP1174B, ASP1182B, ASP1184B, ASP1226B, ASP1248B, ASP1250B, ASP1278B, ASP1367B, ASP2018C, ASP2024C, ASP2055C, ASP2070C, ASP2344C, ASP2364C, ASP2367C, GLN1220B, GLN1244B, GLN1269B, GLN2069C, GLN2350C, GLN2355C, GLU1048B, GLU1247B, GLU1272B, GLU1373B, GLU2028C, GLU2072C, GLU2303C, GLU2373C, GLY1046B, GLY1179B, GLY1242B, GLY1275B, GLY1371B, GLY2302C, GLY2353C, GLY2371C, HIS1060B, HIS1245B, HIS1265B, HIS2060C, HIS2304C, ILE1222B, ILE1227B, ILE1243B, ILE1260B, ILE1283B, LEU1171B, LEU1270B, LEU1280B, LEU2062C, LEU2063C, LEU2067C, LEU2351C, LEU2363C, LEU2365C, LYS1059B, LYS1061B, LYS1149B, LYS1186B, LYS1188B, LYS1219B, LYS1221B, LYS1241B, LYS2059C, LYS2061C, LYS2307C, LYS2343C, MET1251B, MET2349C, PHE1277B, PHE2366C, PRO1224B, PRO1246B, PRO1274B, PRO1281B, PRO1369B, PRO2065C, PRO2074C, PRO2369C, SER1045B, SER1175B, SER1178B, SER1218B, SER1223B, SER1263B, SER1276B, THR1050B, THR1172B, THR1176B, THR1279B, THR2346C, THR2352C, TRP1049B, TRP1058B, TRP1261B, TRP2058C, TYR1215B, TYR1271B, TYR1370B, TYR1372B, TYR1374B, TYR2023C, TYR2064C, TYR2340C, TYR2370C, TYR2372C, TYR2374C, VAL1177B, VAL1185B, VAL1240B, VAL1262B, VAL2019C, VAL2020C, VAL2071C, VAL2348C
• B-D: ALA1057B, ALA1068B, ALA1073B, ALA1306B, ALA3053D, ALA3057D, ALA3173D, ALA3249D, ALA3252D, ALA3267D, ALA3273D, ALA3282D, ARG1056B, ARG1066B, ARG1300B, ARG1301B, ARG1347B, ARG3052D, ARG3056D, ARG3181D, ARG3183D, ARG3225D, ARG3255D, ARG3268D, ASN1021B, ASN1368B, ASN3054D, ASN3180D, ASN3187D, ASN3212D, ASN3264D, ASN3368D, ASP1018B, ASP1024B, ASP1055B, ASP1070B, ASP1344B, ASP1364B, ASP1367B, ASP3047D, ASP3055D, ASP3174D, ASP3182D, ASP3184D, ASP3226D, ASP3248D, ASP3250D, ASP3278D, ASP3367D, GLN1069B, GLN1350B, GLN1355B, GLN3220D, GLN3244D, GLN3269D, GLU1028B, GLU1072B, GLU1303B, GLU1373B, GLU3048D, GLU3247D, GLU3272D, GLU3373D, GLY1302B, GLY1353B, GLY1371B, GLY3046D, GLY3179D, GLY3216D, GLY3242D, GLY3275D, GLY3371D, HIS1060B, HIS1304B, HIS3060D, HIS3245D, HIS3265D, ILE3222D, ILE3227D, ILE3243D, ILE3260D, ILE3283D, LEU1062B, LEU1063B, LEU1067B, LEU1351B, LEU1363B, LEU1365B, LEU3171D, LEU3270D, LEU3280D, LYS1059B, LYS1061B, LYS1307B, LYS1343B, LYS3059D, LYS3061D, LYS3149D, LYS3186D, LYS3188D, LYS3219D, LYS3221D, LYS3241D, MET1349B, MET3251D, PHE1366B, PHE3277D, PRO1065B, PRO1074B, PRO1369B, PRO3224D, PRO3246D, PRO3274D, PRO3281D, PRO3369D, SER3045D, SER3175D, SER3178D, SER3218D, SER3223D, SER3263D, SER3276D, THR1346B, THR1352B, THR3050D, THR3172D, THR3176D, THR3279D, TRP1058B, TRP3049D, TRP3058D, TRP3261D, TYR1023B, TYR1064B, TYR1340B, TYR1370B, TYR1372B, TYR1374B, TYR3215D, TYR3271D, TYR3370D, TYR3372D, TYR3374D, VAL1019B, VAL1020B, VAL1071B, VAL1348B, VAL3177D, VAL3185D, VAL3240D, VAL3262D
• C-D: ARG2052C, ARG2056C, ARG3052D, GLU2373C, GLU3373D