2E2M

crystal structure of archaeal peroxiredoxin, thioredoxin peroxidase from aeropyrum pernix k1 (sulfinic acid form)

• Total interactions analyzed: 45
• Total true interactions: 20
• Strongest Interaction:
  • Chains: I-J
  • Int. Res.: 251
  • Norm. En. per Res.: -5.345
• Hub Node: A(4)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-129.9821	-178.2209	-979.092	-1287.295	255	46	42	39564	12	106	80
A-C	-13.9728	-0.846	-96.084	-110.9027	39	2	1	3753	4	19	15
A-I	-16.871	3.4777	-108.683	-122.0763	41	2	1	3993	3	19	14
A-J	-27.823	43.4666	-182.829	-167.1854	72	5	4	7528	0	19	29
B-C	-38.1014	44.4947	-206.964	-200.5707	79	9	4	8208	0	21	32
B-D	-32.1871	-4.7288	-101.281	-138.1969	39	3	1	3767	4	19	16
B-J	-22.897	-7.8593	-103.035	-133.7913	41	3	1	3868	3	19	16
C-D	-183.6554	-187.1444	-954.714	-1325.5138	259	44	39	38903	12	104	84
C-E	-8.4756	14.2903	-101.729	-95.9142	41	2	1	3842	2	19	17
D-E	-34.7208	41.6052	-179.11	-172.2256	73	9	4	7562	0	19	29
D-F	-31.5726	-6.5663	-99.9506	-138.0895	39	3	1	3794	4	19	16
E-F	-152.6678	-139.0968	-986.149	-1277.9136	256	45	43	39871	12	104	82
E-G	-23.6462	0.8282	-95.4536	-118.2716	41	4	1	3693	3	19	17
F-G	-32.0539	42.4188	-196.102	-185.7371	70	7	4	7686	0	19	29
F-H	-31.1458	1.1255	-95.9974	-126.0177	41	3	1	3768	4	19	16
G-H	-174.9786	-166.0102	-973.51	-1314.4988	261	51	42	39774	12	101	86
G-I	-29.2638	2.5631	-108.258	-134.9587	38	4	1	3688	4	19	16
H-I	-36.5708	35.8259	-195.334	-196.079	78	6	4	8036	0	20	32
H-J	-10.9959	6.8793	-105.522	-109.6386	40	2	1	3779	2	19	15
I-J	-161.3442	-174.6425	-1005.6	-1341.5867	251	47	42	40098	11	102	87

Interface residues

• A-B: ALA121A, ALA121B, ALA160A, ALA160B, ALA170A, ALA170B, ALA173A, ALA173B, ALA226A, ALA226B, ALA233A, ALA233B, ALA234A, ALA234B, ALA238A, ALA238B, ALA245B, ALA44A, ALA44B, ALA58A, ARG126A, ARG126B, ARG134A, ARG138A, ARG138B, ARG149A, ARG149B, ARG156A, ARG156B, ARG169A, ARG169B, ARG199B, ARG206A, ARG206B, ARG227A, ARG227B, ARG228A, ARG228B, ARG231A, ARG231B, ARG232A, ARG232B, ARG59A, ARG59B, ARG60A, ARG60B, ARG91A, ASN177A, ASN177B, ASN178A, ASN178B, ASP152A, ASP152B, ASP165A, ASP165B, ASP174A, ASP174B, ASP209A, ASP209B, ASP45A, ASP45B, CYS213A, CYS213B, GLU10A, GLU10B, GLU146A, GLU146B, GLU153A, GLU153B, GLU179A, GLU179B, GLU183A, GLU183B, GLU235A, GLU235B, GLU243A, GLU243B, GLU244B, GLU53A, GLU53B, GLY114A, GLY114B, GLY127A, GLY127B, GLY148A, GLY148B, GLY164A, GLY164B, GLY182A, GLY182B, GLY184A, GLY184B, GLY94B, GLY9A, GLY9B, HIS123A, HIS123B, HIS42A, HIS42B, HIS92A, HIS92B, ILE130A, ILE130B, ILE137A, ILE137B, ILE154A, ILE154B, ILE157A, ILE157B, ILE180A, ILE180B, ILE181A, ILE181B, ILE186A, ILE186B, ILE5A, ILE5B, ILE89A, ILE89B, ILE8A, ILE8B, ILE93A, ILE93B, ILE97A, ILE97B, LEU113A, LEU113B, LEU115A, LEU115B, LEU116A, LEU116B, LEU141A, LEU141B, LEU147A, LEU147B, LEU150A, LEU150B, LEU161A, LEU161B, LEU163B, LEU185A, LEU185B, LEU208A, LEU208B, LEU230A, LEU230B, LEU240A, LEU240B, LEU241A, LEU241B, LEU7A, LEU7B, LYS159A, LYS159B, LYS162A, LYS162B, LYS168B, LYS236A, LYS236B, LYS239A, LYS239B, LYS84A, LYS84B, MET140A, MET140B, MET145A, MET145B, PHE129B, PHE212A, PHE212B, PHE46A, PHE46B, PHE54A, PHE54B, PHE57A, PHE57B, PRO144A, PRO144B, PRO172A, PRO172B, PRO176A, PRO176B, PRO188A, PRO188B, PRO189A, PRO189B, PRO190A, PRO190B, PRO237A, PRO237B, PRO48A, PRO48B, PRO6A, PRO6B, SER207A, SER207B, SER4A, SER56A, SER56B, THR124A, THR124B, THR139A, THR139B, THR191A, THR191B, THR216A, THR216B, THR47A, THR47B, THR51A, THR51B, THR52A, THR52B, TRP175A, TRP175B, TRP210A, TRP210B, TRP211A, TRP211B, TRP214A, TRP214B, TRP36A, TRP36B, TRP85A, TRP85B, TRP88A, TRP88B, TYR142A, TYR142B, TYR143A, TYR143B, TYR229A, TYR229B, TYR242A, TYR242B, VAL125A, VAL125B, VAL128A, VAL128B, VAL151A, VAL151B, VAL158A, VAL158B, VAL171A, VAL171B, VAL187A, VAL187B, VAL223A, VAL223B, VAL49A, VAL49B, VAL55A, VAL55B, VAL95A, VAL95B
• A-C: ALA196A, ARG197A, ARG96C, ASP194A, ASP209A, ASP20C, GLN195A, GLU193A, GLU87C, GLU90C, GLY22C, HIS21C, HIS82C, ILE101C, ILE83C, ILE97C, LEU208A, LYS84C, LYS86C, MET200A, PHE212A, PHE80C, PHE99C, PRO100C, PRO188A, PRO189A, PRO190A, PRO98C, SER78C, SER81C, THR18C, THR191A, THR192A, THR19C, TRP210A, TRP211A, TRP85C, VAL23C, VAL79C
• A-I: ALA103A, ALA196I, ARG197I, ARG96A, ASP194I, ASP209I, ASP20A, GLN195I, GLU193I, GLU87A, GLU90A, GLY22A, HIS21A, HIS82A, ILE101A, ILE83A, ILE97A, LEU208I, LYS84A, LYS86A, MET200I, PHE212I, PHE46A, PHE80A, PHE99A, PRO100A, PRO188I, PRO189I, PRO190I, PRO98A, SER78A, SER81A, THR18A, THR191I, THR192I, THR19A, TRP210I, TRP211I, TRP85A, VAL23A, VAL79A
• A-J: ALA103J, ALA110A, ALA110J, ALA121A, ALA121J, ALA44A, ALA44J, ARG111A, ARG111J, ARG91A, ARG91J, ASP104A, ASP104J, ASP45A, ASP45J, ASP77A, ASP77J, GLN106A, GLN106J, GLY107A, GLY107J, HIS123A, HIS123J, HIS82A, HIS82J, HIS92A, HIS92J, ILE83A, ILE83J, LEU115J, LEU116A, LEU116J, LYS84A, LYS84J, MET145A, MET145J, PHE46A, PHE46J, PHE80A, PHE80J, PRO105A, PRO105J, PRO43A, PRO43J, PRO48A, PRO48J, SER75A, SER75J, SER78A, SER78J, SER81A, SER81J, THR108A, THR108J, THR122A, THR122J, THR124A, THR124J, THR18A, THR18J, THR47A, THR47J, TRP85A, TRP85J, TRP88A, TRP88J, VAL125A, VAL125J, VAL76A, VAL76J, VAL79A, VAL79J
• B-C: ALA103B, ALA103C, ALA110B, ALA110C, ALA118C, ALA121B, ALA121C, ALA44B, ALA44C, ARG111B, ARG111C, ARG112B, ARG91B, ARG91C, ASP104B, ASP104C, ASP45B, ASP45C, ASP77B, ASP77C, GLN106B, GLN106C, GLU119C, GLU16B, GLY107B, GLY107C, HIS117C, HIS123B, HIS123C, HIS82B, HIS82C, HIS92B, HIS92C, ILE83B, ILE83C, LEU115B, LEU115C, LEU116B, LEU116C, LYS84B, LYS84C, MET145C, PHE46B, PHE46C, PHE80B, PHE80C, PRO105B, PRO105C, PRO43B, PRO43C, PRO48B, PRO48C, SER120C, SER75B, SER75C, SER78B, SER78C, SER81B, SER81C, THR108B, THR108C, THR122B, THR122C, THR124B, THR124C, THR18B, THR18C, THR47B, THR47C, TRP85B, TRP85C, TRP88B, TRP88C, VAL125B, VAL125C, VAL76B, VAL76C, VAL79B, VAL79C
• B-D: ALA103B, ALA196D, ARG197D, ARG96B, ASP194D, ASP209D, ASP20B, GLN195D, GLU193D, GLU87B, GLU90B, GLY22B, HIS21B, HIS82B, ILE101B, ILE83B, ILE97B, LEU208D, LYS84B, LYS86B, MET200D, PHE212D, PHE80B, PHE99B, PRO100B, PRO188D, PRO189D, PRO190D, PRO98B, SER81B, THR18B, THR191D, THR192D, THR19B, TRP210D, TRP211D, TRP85B, VAL23B, VAL79B
• B-J: ALA103J, ALA196B, ARG197B, ARG96J, ASP194B, ASP209B, ASP20J, GLN195B, GLU193B, GLU87J, GLU90J, GLY22J, HIS21J, HIS82J, ILE101J, ILE83J, ILE97J, LEU208B, LYS84J, LYS86J, MET200B, PHE212B, PHE46J, PHE80J, PHE99J, PRO100J, PRO188B, PRO189B, PRO190B, PRO98J, SER78J, SER81J, THR18J, THR191B, THR192B, THR19J, TRP210B, TRP211B, TRP85J, VAL23J, VAL79J
• C-D: ALA118C, ALA121C, ALA121D, ALA160C, ALA160D, ALA170C, ALA170D, ALA173C, ALA173D, ALA226C, ALA226D, ALA233C, ALA233D, ALA234C, ALA234D, ALA238C, ALA238D, ALA245C, ALA44C, ALA44D, ALA58D, ARG126C, ARG126D, ARG134C, ARG138C, ARG138D, ARG149C, ARG149D, ARG156C, ARG156D, ARG169C, ARG169D, ARG199C, ARG199D, ARG206C, ARG206D, ARG227C, ARG227D, ARG228C, ARG228D, ARG231C, ARG231D, ARG232C, ARG232D, ARG59C, ARG59D, ARG60C, ARG60D, ASN177C, ASN177D, ASN178C, ASN178D, ASP152C, ASP152D, ASP165C, ASP165D, ASP174C, ASP174D, ASP209C, ASP209D, ASP45C, ASP45D, CYS213C, CYS213D, GLU10C, GLU10D, GLU146C, GLU146D, GLU153C, GLU153D, GLU179C, GLU179D, GLU183C, GLU183D, GLU235C, GLU235D, GLU243C, GLU244C, GLU53C, GLU53D, GLY114C, GLY114D, GLY127C, GLY127D, GLY148C, GLY148D, GLY164C, GLY164D, GLY182C, GLY182D, GLY184C, GLY184D, GLY94C, GLY9C, GLY9D, HIS117C, HIS123C, HIS123D, HIS42C, HIS42D, HIS92C, HIS92D, ILE130C, ILE130D, ILE137C, ILE137D, ILE154C, ILE154D, ILE157C, ILE157D, ILE180C, ILE180D, ILE181C, ILE181D, ILE186C, ILE186D, ILE5C, ILE89C, ILE89D, ILE8C, ILE8D, ILE93C, ILE93D, ILE97C, ILE97D, LEU113C, LEU113D, LEU115C, LEU115D, LEU116C, LEU116D, LEU141C, LEU141D, LEU147C, LEU147D, LEU150C, LEU150D, LEU155C, LEU161C, LEU161D, LEU163C, LEU185C, LEU185D, LEU208C, LEU208D, LEU230C, LEU230D, LEU240C, LEU240D, LEU241C, LEU241D, LEU7C, LEU7D, LYS159C, LYS159D, LYS162C, LYS162D, LYS168C, LYS168D, LYS236C, LYS236D, LYS239C, LYS239D, LYS84C, LYS84D, MET140C, MET140D, MET145C, MET145D, PHE129C, PHE129D, PHE212C, PHE212D, PHE46C, PHE46D, PHE54C, PHE54D, PHE57C, PHE57D, PRO144C, PRO144D, PRO172C, PRO172D, PRO176C, PRO176D, PRO188C, PRO188D, PRO189C, PRO189D, PRO190C, PRO190D, PRO237C, PRO237D, PRO48C, PRO48D, PRO6C, PRO6D, SER207C, SER207D, SER4C, SER56C, SER56D, THR124C, THR124D, THR139C, THR139D, THR191C, THR191D, THR216C, THR216D, THR47C, THR47D, THR51C, THR51D, THR52C, THR52D, TRP175C, TRP175D, TRP210C, TRP210D, TRP211C, TRP211D, TRP214C, TRP214D, TRP36C, TRP36D, TRP85C, TRP85D, TRP88C, TRP88D, TYR142C, TYR142D, TYR143C, TYR143D, TYR229C, TYR229D, TYR242C, TYR242D, VAL125C, VAL125D, VAL128C, VAL128D, VAL136C, VAL151C, VAL151D, VAL158C, VAL158D, VAL171C, VAL171D, VAL187C, VAL187D, VAL223C, VAL223D, VAL49C, VAL49D, VAL55C, VAL55D, VAL95C, VAL95D
• C-E: ALA103E, ALA196C, ARG197C, ARG199C, ARG96E, ASP194C, ASP209C, ASP20E, GLN195C, GLU193C, GLU87E, GLU90E, GLY22E, HIS21E, HIS82E, ILE101E, ILE83E, ILE97E, LEU208C, LYS84E, LYS86E, MET200C, PHE212C, PHE80E, PHE99E, PRO100E, PRO188C, PRO189C, PRO190C, PRO98E, SER78E, SER81E, THR18E, THR191C, THR192C, THR19E, TRP210C, TRP211C, TRP85E, VAL23E, VAL79E
• D-E: ALA103D, ALA110D, ALA110E, ALA121D, ALA121E, ALA44D, ALA44E, ARG111D, ARG111E, ARG91D, ARG91E, ASP104D, ASP104E, ASP45D, ASP45E, ASP77D, ASP77E, GLN106D, GLN106E, GLU87D, GLY107D, GLY107E, HIS123D, HIS123E, HIS82D, HIS82E, HIS92D, HIS92E, ILE83D, ILE83E, LEU115D, LEU115E, LEU116D, LEU116E, LYS84D, LYS84E, MET145D, MET145E, PHE46D, PHE46E, PHE80D, PHE80E, PRO105D, PRO105E, PRO43D, PRO43E, PRO48D, PRO48E, SER75D, SER75E, SER78D, SER78E, SER81D, SER81E, THR108D, THR108E, THR122D, THR122E, THR124D, THR124E, THR18D, THR47D, THR47E, TRP85D, TRP85E, TRP88D, TRP88E, VAL125D, VAL125E, VAL76D, VAL76E, VAL79D, VAL79E
• D-F: ALA103D, ALA196F, ARG197F, ARG96D, ASP194F, ASP209F, ASP20D, GLN195F, GLU193F, GLU87D, GLU90D, GLY22D, HIS21D, HIS82D, ILE101D, ILE83D, ILE97D, LEU208F, LYS84D, LYS86D, MET200F, PHE46D, PHE80D, PHE99D, PRO100D, PRO188F, PRO189F, PRO190F, PRO98D, SER81D, THR18D, THR191F, THR192F, THR19D, TRP210F, TRP211F, TRP85D, VAL23D, VAL79D
• E-F: ALA110E, ALA121E, ALA121F, ALA160E, ALA160F, ALA170E, ALA170F, ALA173E, ALA173F, ALA226E, ALA226F, ALA233E, ALA233F, ALA234E, ALA234F, ALA238E, ALA238F, ALA245E, ALA245F, ALA44E, ALA58E, ARG111F, ARG126E, ARG126F, ARG138E, ARG138F, ARG149E, ARG149F, ARG156E, ARG156F, ARG169E, ARG169F, ARG206E, ARG206F, ARG227E, ARG227F, ARG228E, ARG228F, ARG231E, ARG231F, ARG232E, ARG232F, ARG59E, ARG59F, ARG60E, ARG60F, ASN177E, ASN177F, ASN178E, ASN178F, ASP152E, ASP152F, ASP165E, ASP165F, ASP174E, ASP174F, ASP209E, ASP209F, ASP45E, ASP45F, CYS213E, CYS213F, GLU10E, GLU10F, GLU146E, GLU146F, GLU153E, GLU153F, GLU179E, GLU179F, GLU183E, GLU183F, GLU235E, GLU235F, GLU243E, GLU243F, GLU244E, GLU244F, GLU53E, GLU53F, GLY114E, GLY114F, GLY127E, GLY127F, GLY148E, GLY148F, GLY164E, GLY164F, GLY182E, GLY182F, GLY184E, GLY184F, GLY9E, GLY9F, HIS123E, HIS123F, HIS42E, HIS42F, HIS92E, HIS92F, ILE130E, ILE130F, ILE137E, ILE137F, ILE154E, ILE154F, ILE157E, ILE157F, ILE180E, ILE180F, ILE181E, ILE181F, ILE186E, ILE186F, ILE5E, ILE5F, ILE89E, ILE89F, ILE8E, ILE8F, ILE93E, ILE93F, ILE97E, ILE97F, LEU113E, LEU113F, LEU115E, LEU115F, LEU116E, LEU116F, LEU141E, LEU141F, LEU147E, LEU147F, LEU150E, LEU150F, LEU161E, LEU161F, LEU185E, LEU185F, LEU208E, LEU208F, LEU230E, LEU230F, LEU240E, LEU240F, LEU241E, LEU241F, LEU7E, LEU7F, LYS159E, LYS159F, LYS162E, LYS162F, LYS168F, LYS236E, LYS236F, LYS239E, LYS239F, LYS84E, LYS84F, MET140E, MET140F, MET145E, MET145F, PHE129E, PHE129F, PHE212E, PHE212F, PHE46E, PHE46F, PHE54E, PHE54F, PHE57E, PHE57F, PRO144E, PRO144F, PRO172E, PRO172F, PRO176E, PRO176F, PRO188E, PRO188F, PRO189E, PRO189F, PRO190E, PRO190F, PRO237E, PRO237F, PRO48E, PRO48F, PRO6E, PRO6F, SER207E, SER207F, SER41F, SER4E, SER4F, SER56E, SER56F, THR124E, THR124F, THR139E, THR139F, THR191E, THR191F, THR216E, THR216F, THR47E, THR47F, THR51E, THR51F, THR52E, THR52F, TRP175E, TRP175F, TRP210E, TRP210F, TRP211E, TRP211F, TRP214E, TRP214F, TRP36E, TRP36F, TRP85E, TRP85F, TRP88E, TRP88F, TYR142E, TYR142F, TYR143E, TYR143F, TYR229E, TYR229F, TYR242E, TYR242F, VAL125E, VAL125F, VAL128E, VAL128F, VAL151E, VAL151F, VAL158E, VAL158F, VAL171E, VAL171F, VAL187E, VAL187F, VAL223E, VAL223F, VAL49E, VAL49F, VAL55E, VAL55F, VAL95E, VAL95F
• E-G: ALA103G, ALA196E, ARG197E, ARG96G, ASP194E, ASP209E, ASP20G, GLN195E, GLU193E, GLU87G, GLU90G, GLY22G, HIS21G, HIS82G, ILE101G, ILE83G, ILE97G, LEU208E, LYS84G, LYS86G, MET200E, PHE212E, PHE46G, PHE80G, PHE99G, PRO100G, PRO188E, PRO189E, PRO190E, PRO98G, SER78G, SER81G, THR18G, THR191E, THR192E, THR19G, TRP210E, TRP211E, TRP85G, VAL23G, VAL79G
• F-G: ALA103F, ALA110F, ALA110G, ALA121F, ALA121G, ALA44F, ALA44G, ARG111F, ARG111G, ARG91F, ARG91G, ASP104F, ASP104G, ASP45F, ASP45G, ASP77F, ASP77G, GLN106F, GLN106G, GLY107F, GLY107G, HIS123F, HIS123G, HIS82F, HIS82G, HIS92F, HIS92G, ILE83F, ILE83G, LEU116F, LEU116G, LYS84F, LYS84G, MET145F, MET145G, PHE46F, PHE46G, PHE80F, PHE80G, PRO105F, PRO105G, PRO43F, PRO43G, PRO48F, PRO48G, SER75F, SER75G, SER78F, SER78G, SER81F, SER81G, THR108F, THR108G, THR122F, THR122G, THR124F, THR124G, THR18F, THR47F, THR47G, TRP85F, TRP85G, TRP88F, TRP88G, VAL125F, VAL125G, VAL76F, VAL76G, VAL79F, VAL79G
• F-H: ALA103F, ALA196H, ARG197H, ARG96F, ASP194H, ASP209H, ASP20F, GLN195H, GLU193H, GLU87F, GLU90F, GLY22F, HIS21F, HIS82F, ILE101F, ILE83F, ILE97F, LEU208H, LYS84F, LYS86F, MET200H, PHE212H, PHE46F, PHE80F, PHE99F, PRO100F, PRO188H, PRO189H, PRO190H, PRO98F, SER78F, SER81F, THR18F, THR191H, THR192H, THR19F, TRP210H, TRP211H, TRP85F, VAL23F, VAL79F
• G-H: ALA110G, ALA118H, ALA121G, ALA121H, ALA160G, ALA160H, ALA170G, ALA170H, ALA173G, ALA173H, ALA226G, ALA226H, ALA233G, ALA233H, ALA234G, ALA234H, ALA238G, ALA238H, ALA245G, ALA245H, ALA44G, ALA44H, ALA58G, ARG126G, ARG126H, ARG134G, ARG138G, ARG138H, ARG149G, ARG149H, ARG156G, ARG156H, ARG169G, ARG169H, ARG206G, ARG206H, ARG227G, ARG227H, ARG228G, ARG228H, ARG231G, ARG231H, ARG232G, ARG232H, ARG59G, ARG59H, ARG60G, ARG60H, ASN177G, ASN177H, ASN178G, ASN178H, ASP132H, ASP152G, ASP152H, ASP165G, ASP165H, ASP174G, ASP174H, ASP209G, ASP209H, ASP45G, ASP45H, CYS213G, CYS213H, GLU10G, GLU10H, GLU146G, GLU146H, GLU153G, GLU153H, GLU179G, GLU179H, GLU183G, GLU183H, GLU235G, GLU235H, GLU243G, GLU243H, GLU244G, GLU244H, GLU53G, GLU53H, GLY114G, GLY114H, GLY127G, GLY127H, GLY148G, GLY148H, GLY164G, GLY164H, GLY182G, GLY182H, GLY184G, GLY184H, GLY94G, GLY9G, GLY9H, HIS123G, HIS123H, HIS42G, HIS42H, HIS92G, HIS92H, ILE130G, ILE130H, ILE137G, ILE137H, ILE154G, ILE154H, ILE157G, ILE157H, ILE180G, ILE180H, ILE181G, ILE181H, ILE186G, ILE186H, ILE5G, ILE5H, ILE89G, ILE89H, ILE8G, ILE8H, ILE93G, ILE93H, ILE97G, ILE97H, LEU113G, LEU113H, LEU115G, LEU115H, LEU116G, LEU116H, LEU141G, LEU141H, LEU147G, LEU147H, LEU150G, LEU150H, LEU155H, LEU161G, LEU161H, LEU163H, LEU185G, LEU185H, LEU208G, LEU208H, LEU230G, LEU230H, LEU240G, LEU240H, LEU241G, LEU241H, LEU7G, LEU7H, LYS159G, LYS159H, LYS162G, LYS162H, LYS236G, LYS236H, LYS239G, LYS239H, LYS84G, LYS84H, MET140G, MET140H, MET145G, MET145H, PHE129G, PHE129H, PHE212G, PHE212H, PHE46G, PHE46H, PHE54G, PHE54H, PHE57G, PHE57H, PRO144G, PRO144H, PRO172G, PRO172H, PRO176G, PRO176H, PRO188G, PRO188H, PRO189G, PRO189H, PRO190G, PRO190H, PRO237G, PRO237H, PRO48G, PRO48H, PRO6G, PRO6H, SER207G, SER207H, SER4G, SER4H, SER56G, SER56H, THR124G, THR124H, THR139G, THR139H, THR191G, THR191H, THR216G, THR216H, THR47G, THR47H, THR51G, THR51H, THR52G, THR52H, TRP175G, TRP175H, TRP210G, TRP210H, TRP211G, TRP211H, TRP214G, TRP214H, TRP36G, TRP36H, TRP85G, TRP85H, TRP88G, TRP88H, TYR142G, TYR142H, TYR143G, TYR143H, TYR229G, TYR229H, TYR242G, TYR242H, VAL125G, VAL125H, VAL128G, VAL128H, VAL136H, VAL151G, VAL151H, VAL158G, VAL158H, VAL171G, VAL171H, VAL187G, VAL187H, VAL223G, VAL223H, VAL49G, VAL49H, VAL55G, VAL55H, VAL95G, VAL95H
• G-I: ALA103I, ALA196G, ARG197G, ARG96I, ASP194G, ASP209G, ASP20I, GLN195G, GLU193G, GLU87I, GLU90I, GLY22I, HIS21I, HIS82I, ILE101I, ILE83I, ILE97I, LEU208G, LYS84I, LYS86I, MET200G, PHE80I, PHE99I, PRO100I, PRO188G, PRO189G, PRO190G, PRO98I, SER81I, THR18I, THR191G, THR192G, THR19I, TRP210G, TRP211G, TRP85I, VAL23I, VAL79I
• H-I: ALA103H, ALA103I, ALA110H, ALA110I, ALA118H, ALA121H, ALA121I, ALA44H, ALA44I, ARG111H, ARG111I, ARG112I, ARG91H, ARG91I, ASP104H, ASP104I, ASP45H, ASP45I, ASP77H, ASP77I, GLN106H, GLN106I, GLU119H, GLU16I, GLU87H, GLY107H, GLY107I, HIS123H, HIS123I, HIS82H, HIS82I, HIS92H, HIS92I, ILE83H, ILE83I, LEU116H, LEU116I, LYS84H, LYS84I, MET145H, MET145I, PHE46H, PHE46I, PHE80H, PHE80I, PRO105H, PRO105I, PRO43H, PRO43I, PRO48H, PRO48I, SER120H, SER75H, SER75I, SER78H, SER78I, SER81H, SER81I, THR108H, THR108I, THR122H, THR122I, THR124I, THR18H, THR18I, THR47H, THR47I, TRP85H, TRP85I, TRP88H, TRP88I, VAL109I, VAL125H, VAL125I, VAL76H, VAL76I, VAL79H, VAL79I
• H-J: ALA103H, ALA196J, ARG197J, ARG199J, ARG96H, ASP194J, ASP209J, ASP20H, GLN195J, GLU193J, GLU87H, GLU90H, GLY22H, HIS21H, HIS82H, ILE101H, ILE83H, ILE97H, LEU208J, LYS84H, LYS86H, MET200J, PHE80H, PHE99H, PRO100H, PRO188J, PRO189J, PRO190J, PRO98H, SER78H, SER81H, THR18H, THR191J, THR192J, THR19H, TRP210J, TRP211J, TRP85H, VAL23H, VAL79H
• I-J: ALA121I, ALA121J, ALA160I, ALA160J, ALA170I, ALA170J, ALA173I, ALA173J, ALA226I, ALA226J, ALA233I, ALA233J, ALA234I, ALA234J, ALA238J, ALA245J, ALA44I, ALA44J, ARG126I, ARG126J, ARG138I, ARG138J, ARG149I, ARG149J, ARG156I, ARG156J, ARG169I, ARG169J, ARG206I, ARG206J, ARG227I, ARG227J, ARG228I, ARG228J, ARG231I, ARG231J, ARG232I, ARG232J, ARG59I, ARG59J, ARG60I, ARG60J, ASN177I, ASN177J, ASN178I, ASN178J, ASP152I, ASP152J, ASP165I, ASP165J, ASP174I, ASP174J, ASP209I, ASP209J, ASP45I, ASP45J, CYS213I, CYS213J, GLU10I, GLU10J, GLU146I, GLU146J, GLU153I, GLU153J, GLU179I, GLU179J, GLU183I, GLU183J, GLU235I, GLU235J, GLU243I, GLU243J, GLU244I, GLU244J, GLU53I, GLU53J, GLY114I, GLY114J, GLY127I, GLY127J, GLY148I, GLY148J, GLY164I, GLY164J, GLY182I, GLY182J, GLY184I, GLY184J, GLY94J, GLY9I, GLY9J, HIS123I, HIS123J, HIS42I, HIS42J, HIS92I, HIS92J, ILE130I, ILE130J, ILE137I, ILE137J, ILE154I, ILE154J, ILE157I, ILE157J, ILE180I, ILE180J, ILE181I, ILE181J, ILE186I, ILE186J, ILE5I, ILE5J, ILE89I, ILE89J, ILE8I, ILE8J, ILE93I, ILE93J, ILE97I, ILE97J, LEU113J, LEU115I, LEU115J, LEU116I, LEU116J, LEU141I, LEU141J, LEU147I, LEU147J, LEU150I, LEU150J, LEU161I, LEU161J, LEU185I, LEU185J, LEU208I, LEU208J, LEU230I, LEU230J, LEU240I, LEU240J, LEU241I, LEU241J, LEU7I, LEU7J, LYS159I, LYS159J, LYS162I, LYS162J, LYS168I, LYS168J, LYS236I, LYS236J, LYS239I, LYS239J, LYS84I, LYS84J, MET140I, MET140J, MET145I, MET145J, PHE129J, PHE212I, PHE212J, PHE46I, PHE46J, PHE54I, PHE54J, PHE57I, PHE57J, PRO144I, PRO144J, PRO172I, PRO172J, PRO176I, PRO176J, PRO188I, PRO188J, PRO189I, PRO189J, PRO190I, PRO190J, PRO237I, PRO237J, PRO48I, PRO48J, PRO6I, PRO6J, SER207I, SER207J, SER4I, SER4J, SER56I, SER56J, THR124I, THR124J, THR139I, THR139J, THR191I, THR191J, THR216I, THR216J, THR47I, THR47J, THR51I, THR51J, THR52I, THR52J, TRP175I, TRP175J, TRP210I, TRP210J, TRP211I, TRP211J, TRP214I, TRP214J, TRP36I, TRP36J, TRP85I, TRP85J, TRP88I, TRP88J, TYR142I, TYR142J, TYR143I, TYR143J, TYR229I, TYR229J, TYR242I, TYR242J, VAL125I, VAL125J, VAL128I, VAL128J, VAL151I, VAL151J, VAL158I, VAL158J, VAL171I, VAL171J, VAL187I, VAL187J, VAL223I, VAL223J, VAL49I, VAL49J, VAL55I, VAL55J, VAL95I, VAL95J