2DW7

crystal structure of d-tartrate dehydratase from bradyrhizobium japonicum complexed with mg++ and meso- tartrate

• Total interactions analyzed: 120
• Total true interactions: 35
• Strongest Interaction:
  • Chains: O-P
  • Int. Res.: 171
  • Norm. En. per Res.: -4.7094
• Hub Node: A(6)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-72.5712	-196.757	-553.771	-823.0992	175	37	1	20967	11	84	66
A-C	0.0	11.6394	-37.6514	-26.012	54	3	0	2309	1	24	27
A-D	0.0	0.0	-11.6526	-11.6526	32	2	0	987	0	16	17
A-J	-2.5942	-2.8426	-53.3762	-58.8131	62	11	0	3213	2	34	30
A-K	-6.2454	9.5724	-116.324	-112.997	61	3	0	4612	0	28	30
A-L	-16.6129	20.1781	-31.2072	-27.642	34	2	3	1594	4	2	8
B-C	-16.1595	4.7336	-22.1736	-33.5995	25	1	0	1168	4	13	15
B-D	0.0	0.0	-14.3263	-14.3263	31	1	0	902	0	6	6
B-K	-24.2152	20.1526	-38.5144	-42.5769	34	6	4	1990	4	4	8
B-L	-2.1582	-2.2764	-99.0207	-103.4553	60	4	0	4244	0	28	29
B-O	0.0	-9.9851	-9.3479	-19.333	27	6	0	1071	5	31	27
C-D	-88.8439	-210.358	-500.921	-800.1229	172	44	1	20805	12	84	66
C-F	0.0	-18.9071	-86.1712	-105.0783	61	6	0	3939	2	25	20
C-M	-2.5065	2.5824	-95.1569	-95.081	59	2	0	4031	0	28	29
C-N	-17.9778	20.0614	-36.3509	-34.2673	34	3	5	1795	4	4	8
D-G	0.0	-30.7317	-22.5782	-53.3099	36	0	0	1412	1	23	24
D-M	-23.595	20.8035	-38.0143	-40.8058	34	2	4	1809	3	4	8
D-N	-5.6821	3.9589	-95.8586	-97.5819	59	1	0	4008	0	28	30
D-O	-5.5906	-3.4046	-36.0959	-45.0911	24	5	0	1474	3	19	18
D-P	-3.8635	0.0	-22.6812	-26.5447	26	1	0	1317	0	8	10
E-F	-72.7437	-198.3348	-518.017	-789.0954	174	26	1	20397	12	86	65
F-G	0.0	-2.6603	-94.4073	-97.0676	51	15	1	4034	4	35	31
G-H	-90.9238	-200.396	-512.714	-804.0338	172	39	1	20630	13	84	67
G-I	0.0	-9.0512	-15.5846	-24.6358	35	0	0	1348	0	24	20
G-J	0.0	-15.9248	-22.8507	-38.7755	47	0	0	1706	2	24	26
H-I	0.0	0.0	-12.1851	-12.1851	23	1	0	806	0	4	3
H-J	-2.9953	-3.5302	-14.2099	-20.7355	21	0	0	958	2	15	17
I-J	-89.0954	-170.8464	-527.92	-787.8618	174	39	1	20578	12	84	66
I-K	0.0	-3.8685	-5.0019	-8.8704	14	0	0	433	0	7	5
J-K	0.0	-20.6802	-7.0558	-27.736	19	0	0	628	0	13	8
K-L	-83.285	-199.0117	-525.089	-807.3856	172	41	1	20545	15	84	66
M-N	-79.5538	-116.3375	-509.829	-705.7203	175	42	1	20733	13	83	65
M-P	0.0	0.0	-0.0245	-0.0245	4	0	0	10	0	3	2
N-P	0.0	8.0312	-1.2253	6.8059	7	0	0	115	0	8	7
O-P	-99.5282	-185.7541	-520.029	-805.3112	171	35	1	20533	12	83	65

Interface residues

• A-B: ALA112A, ALA112B, ALA214A, ALA214B, ALA248A, ALA248B, ALA251A, ALA251B, ALA273A, ALA273B, ARG109A, ARG109B, ARG20A, ARG20B, ARG217A, ARG217B, ARG274A, ARG274B, ARG278A, ARG278B, ARG57A, ARG57B, ARG65A, ARG65B, ARG67A, ARG67B, ARG71A, ARG71B, ASN100A, ASN100B, ASN215A, ASN215B, ASN21A, ASN21B, ASN266A, ASN266B, ASN275A, ASN275B, ASN53A, ASN53B, ASN55A, ASN55B, ASP213A, ASP213B, ASP243A, ASP243B, ASP246A, ASP246B, ASP25A, ASP25B, ASP272A, ASP272B, GLN250A, GLN250B, GLN271A, GLN271B, GLN60A, GLN60B, GLU101A, GLU101B, GLU108A, GLU108B, GLU239A, GLU239B, GLU240A, GLU240B, GLU265A, GLU265B, GLU66A, GLU66B, GLU74A, GLU74B, GLY104A, GLY104B, GLY105A, GLY105B, GLY107A, GLY107B, GLY216A, GLY216B, GLY242A, GLY242B, GLY280A, GLY280B, GLY281A, GLY281B, GLY323B, GLY56A, GLY56B, GLY59A, GLY59B, GLY61A, GLY61B, GLY62A, GLY62B, HIS106A, HIS106B, HIS270A, HIS270B, HIS312A, HIS312B, HIS322A, HIS322B, ILE19B, ILE24A, ILE24B, ILE99A, ILE99B, LEU220A, LEU220B, LEU245A, LEU245B, LEU249A, LEU249B, LEU267A, LEU267B, LEU276A, LEU276B, LEU295A, LEU295B, LEU63A, LEU63B, LYS102A, LYS102B, LYS184A, LYS184B, LYS28A, LYS28B, MET29A, MET29B, MET98A, MET98B, PHE268A, PHE268B, PHE26A, PHE26B, PHE347A, PHE347B, PHE68A, PHE68B, PRO103A, PRO103B, PRO244A, PRO244B, SER110A, SER110B, SER269A, SER269B, SER54A, SER54B, SER70A, SER70B, THR12A, THR12B, THR27A, THR27B, THR30A, THR30B, TRP94B, TYR156A, TYR156B, TYR23A, TYR23B, TYR247A, TYR247B, TYR279A, TYR279B, TYR297A, TYR297B, TYR343A, TYR343B, TYR58A, TYR58B, VAL111A, VAL111B
• A-C: ALA35A, ALA386A, ALA386C, ALA388A, ALA388C, ALA69C, ALA75C, ARG46A, ARG46C, ARG4C, ARG65A, ARG65C, ARG67C, ARG71C, ARG9A, ARG9C, ASP39C, ASP7A, ASP7C, GLU10A, GLU10C, GLU383A, GLU389A, GLU389C, GLU66A, GLU66C, GLU74C, GLY61A, GLY62A, ILE11A, ILE5C, ILE64C, LEU33A, LEU387A, LEU387C, LEU73C, LYS13A, LYS28A, LYS382A, LYS385A, LYS385C, LYS78C, MET384A, PRO14A, SER2C, SER70C, THR12A, THR30A, TYR350A, VAL37A, VAL37C, VAL6A, VAL6C, VAL8C
• A-D: ALA386D, ALA75A, ARG46A, ARG4A, ARG65A, ARG65D, ARG9D, ASP39A, ASP76A, ASP7A, GLU10D, GLU383D, GLU66A, GLU74A, ILE11D, ILE5A, LEU387D, LEU73A, LYS13D, LYS28D, LYS382D, LYS385D, LYS78A, LYS79A, PRO14D, PRO77A, SER16D, SER2A, SER70A, THR12D, THR27D, VAL6A
• A-J: ALA128A, ALA144A, ARG134A, ARG147A, ARG171J, ARG176J, ARG358A, ARG358J, ASN145A, ASN179A, ASN361A, ASP175J, ASP345J, ASP355J, ASP368A, ASP379J, GLN348J, GLU138A, GLU360A, GLU360J, GLU43A, GLY129A, GLY172J, GLY177J, GLY356A, GLY356J, GLY362A, HIS363A, ILE15J, ILE364A, LEU174J, LEU346J, LEU369A, LEU380J, LYS130A, LYS143A, LYS377J, LYS382J, LYS385J, MET366A, PHE133A, PHE149A, PHE347J, PRO131A, PRO146A, PRO14J, PRO18J, PRO344J, PRO349J, PRO367A, PRO370A, SER16J, SER17J, SER378J, THR365A, TYR158J, TYR173J, TYR178J, VAL142A, VAL357A, VAL359A, VAL359J
• A-K: ALA251A, ALA251K, ALA252A, ALA252K, ALA254A, ALA254K, ARG274A, ARG274K, ARG278A, ARG278K, ARG283A, ARG283K, ARG286A, ARG286K, ASP285A, ASP285K, ASP287A, ASP287K, GLU255A, GLU255K, GLU307A, GLU307K, GLY259K, GLY281A, GLY281K, GLY313A, GLY313K, HIS312A, HIS312K, LEU253A, LEU253K, LEU277A, LEU277K, LEU309A, LEU309K, LYS310A, LYS310K, MET261K, MET282A, MET282K, PHE256A, PHE256K, PRO258A, PRO258K, PRO260K, PRO284A, PRO284K, PRO316A, PRO316K, SER315A, SER315K, THR311A, THR311K, TRP314A, TRP314K, TYR257A, TYR257K, TYR279A, TYR279K, VAL308A, VAL308K
• A-L: ALA225A, ALA225L, ALA248A, ALA248L, ALA251A, ALA251L, ALA252A, ALA252L, ARG231A, ARG231L, ASN219A, ASN219L, ASP246A, ASP246L, GLU221A, GLU221L, GLU255A, GLU255L, ILE224A, ILE224L, LEU220A, LEU220L, LEU249A, LEU249L, LEU253A, LEU253L, LYS228A, LYS228L, PHE256A, PHE256L, THR222A, THR222L, TYR279A, TYR279L
• B-C: ALA69B, ALA75C, ARG4C, ARG65B, ARG67B, ARG71B, ARG9B, ASP76C, ASP7B, GLU10B, GLU66B, GLU74B, GLU74C, GLY62B, ILE64B, ILE72B, LEU73B, LEU73C, LYS78C, LYS79C, PHE68B, PRO77C, SER2C, SER70B, VAL8B
• B-D: ALA188D, ARG196D, ASP379B, GLN348B, GLU192D, GLU383B, GLY160D, GLY162D, ILE11B, ILE15B, ILE19D, LYS13B, LYS161D, LYS28B, LYS382B, MET165D, MET29B, PRO14B, PRO159D, PRO189D, PRO18D, PRO349B, SER16B, SER16D, SER17B, SER17D, THR12B, THR27B, THR30B, TYR158D, TYR350B
• B-K: ALA225B, ALA225K, ALA248B, ALA248K, ALA251B, ALA251K, ALA252B, ALA252K, ARG231B, ARG231K, ASN219B, ASN219K, ASP246B, ASP246K, GLU221B, GLU221K, GLU255B, GLU255K, ILE224B, ILE224K, LEU220B, LEU220K, LEU249B, LEU249K, LEU253B, LEU253K, LYS228B, LYS228K, PHE256B, PHE256K, THR222B, THR222K, TYR279B, TYR279K
• B-L: ALA251B, ALA251L, ALA252B, ALA252L, ALA254B, ALA254L, ARG274B, ARG274L, ARG278B, ARG278L, ARG283B, ARG283L, ARG286B, ARG286L, ASP285B, ASP285L, ASP287B, ASP287L, GLU255B, GLU255L, GLU307B, GLU307L, GLY259B, GLY281B, GLY281L, GLY313B, GLY313L, HIS312B, HIS312L, LEU253B, LEU253L, LEU277B, LEU277L, LEU309B, LEU309L, LYS310B, LYS310L, MET282B, MET282L, PHE256B, PHE256L, PRO258B, PRO258L, PRO260B, PRO284B, PRO284L, PRO316B, PRO316L, SER315B, SER315L, THR311B, THR311L, TRP314B, TRP314L, TYR257B, TYR257L, TYR279B, TYR279L, VAL308B, VAL308L
• B-O: ALA388O, ARG167B, ARG171B, ARG176B, ARG358B, ARG46O, ARG65O, ARG9O, ASP175B, ASP207B, ASP39O, ASP7O, GLU169B, GLU203B, GLU389O, GLY168B, GLY172B, GLY177B, GLY44O, LEU174B, LYS45O, MET170B, SER164B, TYR173B, VAL37O, VAL41O, VAL6O
• C-D: ALA112C, ALA112D, ALA214C, ALA214D, ALA248C, ALA248D, ALA251C, ALA251D, ALA273C, ALA273D, ARG109C, ARG109D, ARG20C, ARG20D, ARG217C, ARG217D, ARG274C, ARG274D, ARG278C, ARG278D, ARG57C, ARG57D, ARG65D, ARG67C, ARG67D, ARG71C, ARG71D, ASN100C, ASN100D, ASN215C, ASN215D, ASN21C, ASN21D, ASN266C, ASN266D, ASN275C, ASN275D, ASN53C, ASN53D, ASN55C, ASN55D, ASP213C, ASP213D, ASP243C, ASP243D, ASP246C, ASP246D, ASP25C, ASP25D, ASP272C, ASP272D, GLN250C, GLN250D, GLN271C, GLN271D, GLN60C, GLN60D, GLU101C, GLU101D, GLU108C, GLU108D, GLU239C, GLU239D, GLU240C, GLU240D, GLU265C, GLU265D, GLU66C, GLU66D, GLU74C, GLU74D, GLY104C, GLY104D, GLY105C, GLY105D, GLY107C, GLY107D, GLY216C, GLY216D, GLY242C, GLY242D, GLY280C, GLY280D, GLY323C, GLY56C, GLY56D, GLY59C, GLY59D, GLY61C, GLY61D, GLY62C, GLY62D, HIS106C, HIS106D, HIS270C, HIS270D, HIS312C, HIS312D, HIS322C, HIS322D, ILE19C, ILE19D, ILE24C, ILE24D, ILE99C, ILE99D, LEU220C, LEU220D, LEU245C, LEU245D, LEU249C, LEU249D, LEU267C, LEU267D, LEU276C, LEU276D, LEU295C, LEU295D, LEU63C, LEU63D, LYS102C, LYS102D, LYS184C, LYS184D, LYS28C, LYS28D, MET29C, MET29D, MET98C, MET98D, PHE268C, PHE268D, PHE26C, PHE26D, PHE347C, PHE68C, PHE68D, PRO103C, PRO103D, PRO244C, PRO244D, SER110C, SER110D, SER269C, SER269D, SER54C, SER54D, SER70C, SER70D, THR12C, THR12D, THR27C, THR27D, THR30C, THR30D, TRP94C, TYR156C, TYR156D, TYR23C, TYR23D, TYR247C, TYR247D, TYR279C, TYR279D, TYR297C, TYR297D, TYR343C, TYR343D, TYR58C, TYR58D, VAL111C, VAL111D
• C-F: ALA144F, ALA188C, ALA199C, ALA208F, ARG147F, ARG167C, ARG194C, ARG196C, ARG20C, ARG358F, ASN145F, ASN179F, ASN361F, ASP193C, ASP207F, GLN209F, GLU191C, GLU192C, GLU198C, GLU202C, GLU203C, GLU360F, GLY160C, GLY162C, GLY177F, GLY205C, GLY205F, GLY338F, GLY362F, HIS363F, ILE190C, ILE197C, ILE364F, LEU163C, LEU166C, LEU201C, LYS143F, LYS161C, LYS206F, MET165C, MET195C, MET366F, PHE149F, PHE236F, PRO146F, PRO159C, PRO189C, PRO18C, SER164C, SER317F, THR27C, THR365F, TRP288F, TYR157C, TYR158C, TYR233C, VAL148F, VAL180F, VAL200C, VAL357F, VAL359F
• C-M: ALA251C, ALA251M, ALA252C, ALA252M, ALA254C, ALA254M, ARG274C, ARG274M, ARG278C, ARG278M, ARG283C, ARG283M, ARG286C, ARG286M, ASP285C, ASP285M, ASP287C, ASP287M, GLU255C, GLU255M, GLU307C, GLU307M, GLY281C, GLY281M, GLY313C, GLY313M, HIS312C, HIS312M, LEU253C, LEU253M, LEU277C, LEU277M, LEU309C, LEU309M, LYS310C, LYS310M, MET261C, MET282C, MET282M, PHE256C, PHE256M, PRO258C, PRO258M, PRO284C, PRO284M, PRO316C, PRO316M, SER315C, SER315M, THR311C, THR311M, TRP314C, TRP314M, TYR257C, TYR257M, TYR279C, TYR279M, VAL308C, VAL308M
• C-N: ALA225C, ALA225N, ALA248C, ALA248N, ALA251C, ALA251N, ALA252C, ALA252N, ARG231C, ARG231N, ASN219C, ASN219N, ASP246C, ASP246N, GLU221C, GLU221N, GLU255C, GLU255N, ILE224C, ILE224N, LEU220C, LEU220N, LEU249C, LEU249N, LEU253C, LEU253N, LYS228C, LYS228N, PHE256C, PHE256N, THR222C, THR222N, TYR279C, TYR279N
• D-G: ARG147G, ARG167G, ARG171G, ARG176G, ARG358G, ARG42D, ARG46D, ARG4D, ARG9D, ASN179G, ASN361G, ASP175G, ASP207G, ASP39D, ASP76D, GLU202G, GLU203G, GLU360G, GLY172G, GLY177G, GLY205G, GLY362G, ILE204G, LEU174G, LEU81D, LYS206G, LYS78D, PRO77D, SER2D, THR38D, TYR173G, VAL359G, VAL3D, VAL40D, VAL41D, VAL6D
• D-M: ALA225D, ALA225M, ALA248D, ALA248M, ALA251D, ALA251M, ALA252D, ALA252M, ARG231D, ARG231M, ASN219D, ASN219M, ASP246D, ASP246M, GLU221D, GLU221M, GLU255D, GLU255M, ILE224D, ILE224M, LEU220D, LEU220M, LEU249D, LEU249M, LEU253D, LEU253M, LYS228D, LYS228M, PHE256D, PHE256M, THR222D, THR222M, TYR279D, TYR279M
• D-N: ALA251D, ALA251N, ALA252D, ALA252N, ALA254D, ALA254N, ARG274D, ARG274N, ARG278D, ARG278N, ARG283D, ARG283N, ARG286D, ARG286N, ASP285D, ASP285N, ASP287D, ASP287N, GLU255D, GLU255N, GLU307D, GLU307N, GLY281D, GLY281N, GLY313D, GLY313N, HIS312D, HIS312N, LEU253D, LEU253N, LEU277D, LEU277N, LEU309D, LEU309N, LYS310D, LYS310N, MET261N, MET282D, MET282N, PHE256D, PHE256N, PRO258D, PRO258N, PRO284D, PRO284N, PRO316D, PRO316N, SER315D, SER315N, THR311D, THR311N, TRP314D, TRP314N, TYR257D, TYR257N, TYR279D, TYR279N, VAL308D, VAL308N
• D-O: ALA199D, ALA75O, ARG167D, ARG171D, ARG4O, ASP175D, ASP207D, ASP76O, GLU198D, GLU202D, GLU203D, GLU74O, GLY168D, GLY172D, GLY205D, ILE204D, LEU174D, LEU201D, LYS206D, LYS78O, LYS79O, PRO77O, SER164D, VAL200D
• D-P: ALA225D, ALA227D, ARG194D, ARG20P, ARG231D, ASP232D, GLU191D, GLU198D, GLY160P, GLY162P, ILE190D, ILE19P, LEU163P, LEU230D, LYS161P, LYS228D, MET165P, MET195D, MET229D, PRO159P, PRO18P, SER164P, SER17P, THR27P, TYR158P, TYR233D
• E-F: ALA112E, ALA112F, ALA214E, ALA214F, ALA22E, ALA248E, ALA248F, ALA251E, ALA251F, ALA273E, ALA273F, ARG109E, ARG109F, ARG20E, ARG20F, ARG217E, ARG217F, ARG274E, ARG274F, ARG278E, ARG278F, ARG57E, ARG57F, ARG65E, ARG65F, ARG67E, ARG67F, ARG71E, ARG71F, ASN100E, ASN100F, ASN215E, ASN215F, ASN21E, ASN21F, ASN266E, ASN266F, ASN275E, ASN275F, ASN53E, ASN53F, ASN55E, ASN55F, ASP213E, ASP213F, ASP243E, ASP243F, ASP246E, ASP246F, ASP25E, ASP25F, ASP272E, ASP272F, GLN250E, GLN250F, GLN271E, GLN271F, GLN60E, GLN60F, GLU101E, GLU101F, GLU108E, GLU108F, GLU239E, GLU239F, GLU240E, GLU240F, GLU265E, GLU265F, GLU66E, GLU66F, GLU74E, GLU74F, GLY104E, GLY104F, GLY105E, GLY105F, GLY107E, GLY107F, GLY216E, GLY216F, GLY242E, GLY242F, GLY280E, GLY280F, GLY281E, GLY281F, GLY56E, GLY56F, GLY59E, GLY59F, GLY61E, GLY61F, GLY62E, GLY62F, HIS106E, HIS106F, HIS270E, HIS270F, HIS312E, HIS312F, HIS322E, HIS322F, ILE24E, ILE24F, ILE99E, ILE99F, LEU220E, LEU220F, LEU245E, LEU245F, LEU249E, LEU249F, LEU267E, LEU267F, LEU276E, LEU276F, LEU295E, LEU295F, LEU63E, LEU63F, LYS102E, LYS102F, LYS184E, LYS184F, LYS28E, LYS28F, MET29E, MET29F, MET98E, MET98F, PHE268E, PHE268F, PHE26E, PHE26F, PHE347E, PHE347F, PHE68E, PHE68F, PRO103E, PRO103F, PRO244E, PRO244F, SER110E, SER110F, SER269E, SER269F, SER54E, SER54F, SER70E, SER70F, THR12E, THR12F, THR27E, THR27F, THR30E, THR30F, TRP94E, TYR156E, TYR156F, TYR23E, TYR23F, TYR247E, TYR247F, TYR279E, TYR279F, TYR297E, TYR297F, TYR343E, TYR343F, TYR58E, TYR58F, VAL111E, VAL111F
• F-G: ALA188F, ALA188G, ALA199F, ALA199G, ARG167F, ARG167G, ARG194F, ARG194G, ARG196F, ARG196G, ASP193F, ASP193G, GLU191F, GLU191G, GLU192F, GLU192G, GLU198F, GLU198G, GLU202F, GLU202G, GLU203F, GLU203G, GLY160F, GLY160G, GLY162F, GLY162G, ILE190F, ILE190G, ILE197F, ILE197G, LEU163F, LEU163G, LEU166F, LEU166G, LEU201F, LYS161F, LYS161G, MET165F, MET165G, MET195F, MET195G, PRO189F, PRO189G, SER164F, SER164G, TYR157F, TYR157G, TYR233F, TYR233G, VAL200F, VAL200G
• G-H: ALA112G, ALA112H, ALA214G, ALA214H, ALA248G, ALA248H, ALA251G, ALA251H, ALA273G, ALA273H, ARG109G, ARG109H, ARG20G, ARG20H, ARG217G, ARG217H, ARG274G, ARG274H, ARG278G, ARG278H, ARG57G, ARG57H, ARG65G, ARG65H, ARG67G, ARG67H, ARG71G, ARG71H, ASN100G, ASN100H, ASN215G, ASN215H, ASN21G, ASN21H, ASN266G, ASN266H, ASN275G, ASN275H, ASN53H, ASN55G, ASN55H, ASP213G, ASP213H, ASP243G, ASP243H, ASP246G, ASP246H, ASP25G, ASP25H, ASP272G, ASP272H, GLN250G, GLN250H, GLN271G, GLN271H, GLN60G, GLN60H, GLU101G, GLU101H, GLU108G, GLU108H, GLU239G, GLU239H, GLU240G, GLU240H, GLU265G, GLU265H, GLU66G, GLU66H, GLU74G, GLU74H, GLY104G, GLY104H, GLY105G, GLY105H, GLY107G, GLY107H, GLY216G, GLY216H, GLY242G, GLY242H, GLY280G, GLY280H, GLY56G, GLY56H, GLY59G, GLY59H, GLY61G, GLY61H, GLY62G, GLY62H, HIS106G, HIS106H, HIS270G, HIS270H, HIS312G, HIS312H, HIS322G, HIS322H, ILE19H, ILE24G, ILE24H, ILE99G, ILE99H, LEU220G, LEU220H, LEU245G, LEU245H, LEU249G, LEU249H, LEU267G, LEU267H, LEU276G, LEU276H, LEU295G, LEU295H, LEU63G, LEU63H, LYS102G, LYS102H, LYS184G, LYS184H, LYS28G, LYS28H, MET29G, MET29H, MET98G, MET98H, PHE218G, PHE268G, PHE268H, PHE26G, PHE26H, PHE347G, PHE347H, PHE68G, PHE68H, PRO103G, PRO103H, PRO244G, PRO244H, SER110G, SER110H, SER269G, SER269H, SER54G, SER54H, SER70G, SER70H, THR12G, THR12H, THR27G, THR27H, THR30G, THR30H, TRP94G, TYR156G, TYR156H, TYR23G, TYR23H, TYR247G, TYR247H, TYR279G, TYR279H, TYR297G, TYR297H, TYR343G, TYR343H, TYR58G, TYR58H, VAL111G, VAL111H
• G-I: ALA386I, ALA388I, ALA75G, ARG46G, ARG4G, ARG65G, ARG65I, ARG9I, ASP39G, ASP76G, ASP7G, GLU10I, GLU383I, GLU66G, GLU74G, ILE11I, ILE5G, LEU33I, LEU387I, LEU73G, LYS13I, LYS28I, LYS382I, LYS385I, LYS78G, LYS79G, PRO14I, PRO77G, SER16I, SER2G, SER70G, THR12I, THR27I, TYR350I, VAL6G
• G-J: ALA386G, ALA386J, ALA388G, ALA388J, ALA69J, ALA75J, ARG46J, ARG4J, ARG65G, ARG65J, ARG71J, ARG9G, ARG9J, ASP39J, ASP7G, ASP7J, GLU10G, GLU10J, GLU383G, GLU389G, GLU389J, GLU66G, GLU66J, GLU74J, GLY61G, GLY61J, GLY62G, GLY62J, ILE11G, ILE5J, LEU387G, LEU387J, LEU73J, LYS13G, LYS28G, LYS382G, LYS385G, LYS385J, PRO14G, SER2J, SER70J, THR12G, THR30G, TYR350G, VAL37J, VAL6J, VAL8J
• H-I: GLN348H, GLU192I, GLU383H, GLY160I, GLY162I, ILE11H, ILE15H, LEU163I, LYS13H, LYS161I, LYS28H, LYS382H, PRO14H, PRO159I, PRO18I, PRO349H, SER16H, SER16I, SER17I, THR12H, THR30H, TYR158I, TYR350H
• H-J: ALA69H, ALA75J, ARG4J, ARG65H, ARG71H, ARG9H, ASP76J, ASP7H, GLU10H, GLU66H, GLU74H, GLU74J, ILE72H, LEU73H, LYS78J, LYS79J, PRO77J, SER2J, SER70H, VAL6H, VAL8H
• I-J: ALA112I, ALA112J, ALA214I, ALA214J, ALA248I, ALA248J, ALA251I, ALA251J, ALA273I, ALA273J, ARG109I, ARG109J, ARG20I, ARG20J, ARG217I, ARG217J, ARG274I, ARG274J, ARG278I, ARG278J, ARG57I, ARG57J, ARG65I, ARG65J, ARG67I, ARG67J, ARG71I, ARG71J, ASN100I, ASN100J, ASN215I, ASN215J, ASN21I, ASN21J, ASN266I, ASN266J, ASN275I, ASN275J, ASN53I, ASN53J, ASN55I, ASN55J, ASP213I, ASP213J, ASP243I, ASP243J, ASP246I, ASP246J, ASP25I, ASP25J, ASP272I, ASP272J, GLN250I, GLN250J, GLN271I, GLN271J, GLN60I, GLN60J, GLU101I, GLU101J, GLU108I, GLU108J, GLU239I, GLU239J, GLU240I, GLU240J, GLU265I, GLU265J, GLU66I, GLU66J, GLU74I, GLU74J, GLY104I, GLY104J, GLY105I, GLY105J, GLY107I, GLY107J, GLY216I, GLY216J, GLY242I, GLY242J, GLY280I, GLY280J, GLY281J, GLY56I, GLY56J, GLY59I, GLY59J, GLY61I, GLY61J, GLY62I, GLY62J, HIS106I, HIS106J, HIS270I, HIS270J, HIS312I, HIS312J, HIS322I, HIS322J, ILE19I, ILE19J, ILE24I, ILE24J, ILE99I, ILE99J, LEU220I, LEU220J, LEU245I, LEU245J, LEU249I, LEU249J, LEU267I, LEU267J, LEU276I, LEU276J, LEU295I, LEU295J, LEU63I, LEU63J, LYS102I, LYS102J, LYS184I, LYS184J, LYS28I, LYS28J, MET29I, MET29J, MET98I, MET98J, PHE268I, PHE268J, PHE26I, PHE26J, PHE347I, PHE347J, PHE68I, PHE68J, PRO103I, PRO103J, PRO244I, PRO244J, SER110I, SER110J, SER269I, SER269J, SER54I, SER54J, SER70I, SER70J, THR12I, THR12J, THR27I, THR27J, THR30I, THR30J, TRP94I, TYR156I, TYR156J, TYR23I, TYR23J, TYR247I, TYR247J, TYR279I, TYR279J, TYR297I, TYR297J, TYR343I, TYR343J, TYR58I, TYR58J, VAL111I, VAL111J
• I-K: ALA75I, ARG167K, ARG171K, ASP207K, ASP76I, GLU202K, GLU203K, GLU74I, GLY205K, ILE204K, LYS206K, LYS78I, LYS79I, PRO77I
• J-K: ALA144K, ALA188J, ARG134K, ARG147K, ARG194J, ARG318K, ASN145K, ASN361K, GLU191J, GLU192J, GLU198J, GLY160J, HIS363K, LEU163J, LYS143K, MET195J, PRO146K, PRO189J, THR365K
• K-L: ALA112K, ALA112L, ALA214K, ALA214L, ALA22K, ALA248K, ALA248L, ALA251K, ALA251L, ALA273K, ALA273L, ARG109K, ARG109L, ARG20K, ARG20L, ARG217K, ARG217L, ARG274K, ARG274L, ARG278K, ARG278L, ARG57K, ARG57L, ARG65K, ARG65L, ARG67K, ARG67L, ARG71K, ARG71L, ASN100K, ASN100L, ASN215K, ASN215L, ASN21K, ASN21L, ASN266K, ASN266L, ASN275K, ASN275L, ASN53K, ASN53L, ASN55K, ASN55L, ASP213K, ASP213L, ASP243K, ASP243L, ASP246K, ASP246L, ASP25K, ASP25L, ASP272K, ASP272L, GLN250K, GLN250L, GLN271K, GLN271L, GLN60K, GLN60L, GLU101K, GLU101L, GLU108K, GLU108L, GLU239K, GLU239L, GLU240K, GLU240L, GLU265K, GLU265L, GLU66K, GLU66L, GLU74K, GLU74L, GLY104K, GLY104L, GLY105K, GLY105L, GLY107K, GLY107L, GLY216K, GLY216L, GLY242K, GLY242L, GLY280K, GLY280L, GLY56K, GLY56L, GLY59K, GLY59L, GLY61K, GLY61L, GLY62K, GLY62L, HIS106K, HIS106L, HIS270K, HIS270L, HIS312K, HIS312L, HIS322K, HIS322L, ILE19K, ILE24K, ILE24L, ILE99K, ILE99L, LEU220K, LEU220L, LEU245K, LEU245L, LEU249K, LEU249L, LEU267K, LEU267L, LEU276K, LEU276L, LEU295K, LEU295L, LEU63K, LEU63L, LYS102K, LYS102L, LYS184K, LYS184L, LYS28K, LYS28L, MET29K, MET29L, MET98K, MET98L, PHE268K, PHE268L, PHE26K, PHE26L, PHE347K, PHE347L, PHE68K, PHE68L, PRO103K, PRO103L, PRO244K, PRO244L, SER110K, SER110L, SER269K, SER269L, SER54K, SER54L, SER70K, SER70L, THR12K, THR12L, THR27K, THR27L, THR30K, THR30L, TYR156K, TYR156L, TYR23K, TYR23L, TYR247K, TYR247L, TYR279K, TYR279L, TYR297K, TYR297L, TYR343K, TYR343L, TYR58K, TYR58L, VAL111K, VAL111L
• M-N: ALA112M, ALA112N, ALA214M, ALA214N, ALA22M, ALA22N, ALA248M, ALA248N, ALA251M, ALA251N, ALA273M, ALA273N, ARG109M, ARG109N, ARG20M, ARG20N, ARG217M, ARG217N, ARG274M, ARG274N, ARG278M, ARG278N, ARG57M, ARG57N, ARG65M, ARG65N, ARG67M, ARG67N, ARG71M, ARG71N, ASN100M, ASN100N, ASN215M, ASN215N, ASN21M, ASN21N, ASN266M, ASN266N, ASN275M, ASN275N, ASN53M, ASN55M, ASN55N, ASP213M, ASP213N, ASP243M, ASP243N, ASP246M, ASP246N, ASP25M, ASP25N, ASP272M, ASP272N, GLN250M, GLN250N, GLN271M, GLN271N, GLN60M, GLN60N, GLU101M, GLU101N, GLU108M, GLU108N, GLU239M, GLU239N, GLU240M, GLU240N, GLU265M, GLU265N, GLU66M, GLU66N, GLU74M, GLU74N, GLY104M, GLY104N, GLY105M, GLY105N, GLY107M, GLY107N, GLY216M, GLY216N, GLY242M, GLY242N, GLY280M, GLY280N, GLY281M, GLY281N, GLY56M, GLY56N, GLY59M, GLY59N, GLY61M, GLY61N, GLY62M, GLY62N, HIS106M, HIS106N, HIS270M, HIS270N, HIS312M, HIS312N, HIS322M, HIS322N, ILE19M, ILE19N, ILE24M, ILE24N, ILE99M, ILE99N, LEU220M, LEU220N, LEU245M, LEU245N, LEU249M, LEU249N, LEU267M, LEU267N, LEU276M, LEU276N, LEU295M, LEU295N, LEU63M, LEU63N, LYS102M, LYS102N, LYS184M, LYS184N, LYS28M, LYS28N, MET29M, MET29N, MET98M, MET98N, PHE268M, PHE268N, PHE26M, PHE26N, PHE347M, PHE68M, PHE68N, PRO103M, PRO103N, PRO244M, PRO244N, SER110M, SER110N, SER269M, SER269N, SER54M, SER54N, SER70M, SER70N, THR12M, THR12N, THR27M, THR27N, THR30M, THR30N, TRP94N, TYR156M, TYR156N, TYR23M, TYR23N, TYR247M, TYR247N, TYR279M, TYR279N, TYR297M, TYR297N, TYR343M, TYR343N, TYR58M, TYR58N, VAL111M, VAL111N
• M-P: ARG171P, GLU221M, PRO189M, SER164P
• N-P: ARG194P, ASP232P, GLU198P, GLU83N, LYS206P, LYS79N, TYR233P
• O-P: ALA112O, ALA112P, ALA214O, ALA214P, ALA248O, ALA248P, ALA251O, ALA251P, ALA273O, ALA273P, ARG109O, ARG109P, ARG20O, ARG20P, ARG217O, ARG217P, ARG274O, ARG274P, ARG278O, ARG278P, ARG57O, ARG57P, ARG65O, ARG65P, ARG67O, ARG67P, ARG71O, ARG71P, ASN100O, ASN100P, ASN215O, ASN215P, ASN21O, ASN21P, ASN266O, ASN266P, ASN275O, ASN275P, ASN53O, ASN53P, ASN55O, ASN55P, ASP213O, ASP213P, ASP243O, ASP243P, ASP246O, ASP246P, ASP25O, ASP25P, ASP272O, ASP272P, GLN250O, GLN250P, GLN271O, GLN271P, GLN60O, GLN60P, GLU101O, GLU101P, GLU108O, GLU108P, GLU239O, GLU239P, GLU240O, GLU240P, GLU265O, GLU265P, GLU66O, GLU66P, GLU74O, GLU74P, GLY104O, GLY104P, GLY105O, GLY105P, GLY107O, GLY107P, GLY216O, GLY216P, GLY242O, GLY242P, GLY280O, GLY280P, GLY56O, GLY56P, GLY59O, GLY59P, GLY61O, GLY61P, GLY62O, GLY62P, HIS106O, HIS106P, HIS270O, HIS270P, HIS312O, HIS312P, HIS322O, HIS322P, ILE24O, ILE24P, ILE99O, ILE99P, LEU220O, LEU220P, LEU245O, LEU245P, LEU249O, LEU249P, LEU267O, LEU267P, LEU276O, LEU276P, LEU295O, LEU295P, LEU63O, LEU63P, LYS102O, LYS102P, LYS184O, LYS184P, LYS28O, LYS28P, MET29O, MET29P, MET98O, MET98P, PHE268O, PHE268P, PHE26O, PHE26P, PHE347O, PHE68O, PHE68P, PRO103O, PRO103P, PRO244O, PRO244P, SER110O, SER110P, SER269O, SER269P, SER54O, SER54P, SER70O, SER70P, THR12O, THR12P, THR27O, THR27P, THR30O, THR30P, TRP94P, TYR156O, TYR156P, TYR23O, TYR23P, TYR247O, TYR247P, TYR279O, TYR279P, TYR297O, TYR297P, TYR343O, TYR343P, TYR58O, TYR58P, VAL111O, VAL111P, VAL113P