2DSR

structural basis for the inhibition of insulin-like growth factors by igf binding proteins

• Total interactions analyzed: 3
• Total true interactions: 3
• Strongest Interaction:
  • Chains: B-I
  • Int. Res.: 75
  • Norm. En. per Res.: -3.415
• Hub Node: G(2)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
G-B	-6.3976	8.231	-115.688	-113.8546	55	2	1	4683	0	10	16
G-I	-15.213	-41.0025	-181.426	-237.6415	79	3	7	7078	1	25	13
B-I	-33.3456	-22.0921	-200.686	-256.1237	75	3	9	7733	3	18	9

Interface residues

• G-B: ALA165G, ALA197G, ALA3B, ARG170G, ARG202G, ARG28B, ARG52B, ASP174G, ASP199G, CYS194G, CYS32B, CYS34B, CYS35B, CYS6B, CYS9B, GLN168G, GLN201G, GLU173G, GLU29B, GLY200G, GLY203G, GLY224G, GLY31B, GLY33B, GLY47B, GLY75B, HIS172G, HIS190G, HIS195G, HIS5B, HIS70B, HIS74B, ILE180G, ILE4B, LEU161G, LEU164G, LEU175G, LEU198G, LEU72B, LYS13B, LYS192G, LYS223G, MET73B, PRO196G, PRO30B, PRO7B, PRO8B, SER10B, SER167G, SER169G, THR171G, THR37B, THR50B, TYR49B, VAL48B
• G-I: ALA13I, ALA160G, ALA165G, ALA197G, ALA8I, ARG170G, ARG185G, ARG202G, ARG50I, ASN182G, ASN186G, ASN188G, ASN26I, ASP12I, ASP174G, ASP184G, ASP45I, CYS153G, CYS183G, CYS18I, CYS194G, CYS205G, CYS47I, CYS48I, CYS52I, CYS6I, GLN154G, GLN15I, GLN168G, GLN193G, GLN201G, GLN40I, GLU156G, GLU3I, GLU46I, GLU9I, GLY151G, GLY187G, GLY19I, GLY203G, GLY22I, GLY42I, GLY7I, HIS158G, HIS172G, HIS190G, HIS195G, ILE178G, ILE180G, ILE43I, LEU10I, LEU14I, LEU157G, LEU161G, LEU164G, LEU175G, LEU198G, LEU5I, LYS192G, LYS204G, LYS223G, PHE16I, PHE189G, PHE23I, PHE25I, PHE49I, PRO179G, PRO181G, PRO196G, SER155G, SER169G, SER51I, THR171G, THR4I, TRP206G, TYR176G, TYR24I, VAL11I, VAL44I
• B-I: ALA13I, ALA3B, ALA62I, ALA8I, ARG21I, ARG28B, ARG52B, ARG55I, ARG56I, ARG58B, ASN26I, ASP12I, ASP20I, ASP53I, CYS18I, CYS32B, CYS46B, CYS47I, CYS52I, CYS53B, CYS59B, CYS61I, CYS6B, CYS6I, CYS79B, GLN15I, GLU29B, GLU3I, GLU58I, GLU66B, GLU9I, GLY19I, GLY22I, GLY31B, GLY33B, GLY47B, GLY77B, HIS5B, HIS70B, HIS74B, ILE43I, ILE4B, LEU10I, LEU14I, LEU54I, LEU57I, LEU5I, LEU64I, LEU69B, LEU72B, LYS67B, MET73B, PHE16I, PHE23I, PHE25I, PRO2I, PRO30B, PRO51B, PRO61B, PRO63I, PRO68B, PRO7B, SER51I, THR4I, THR50B, THR71B, TYR24I, TYR49B, TYR60B, TYR60I, VAL11I, VAL17I, VAL48B, VAL65B, VAL78B