2DG0

crystal structure of drp35, a 35kda drug responsive protein from staphylococcus aureus

• Total interactions analyzed: 66
• Total true interactions: 27
• Strongest Interaction:
  • Chains: D-F
  • Int. Res.: 114
  • Norm. En. per Res.: -3.0498
• Hub Node: B(6)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-D	0.0	0.0	-0.2282	-0.2282	3	0	0	48	0	5	0
A-F	0.0	-9.9598	-34.5117	-44.4715	34	1	0	1776	0	20	23
A-K	-35.0072	25.1326	-306.156	-316.0306	114	9	7	12516	0	18	20
B-C	0.0	0.0	-0.7217	-0.7217	10	0	0	157	0	4	2
B-E	0.0	0.0	-0.3538	-0.3538	8	0	0	69	0	4	1
B-F	0.0	-4.0059	-0.203	-4.2089	8	0	0	49	0	5	2
B-G	0.0	-13.7616	-12.9473	-26.709	28	1	0	809	0	6	5
B-H	-15.3386	-3.2385	-104.117	-122.6941	69	10	1	4875	0	11	19
B-K	0.0	5.0668	-54.5325	-49.4657	48	5	0	3018	0	17	14
C-F	0.0	0.0	-0.0513	-0.0513	2	0	0	17	0	1	1
C-G	0.0	9.8117	-6.1164	3.6953	25	0	0	683	0	20	17
C-K	0.0	1.2451	-41.7433	-40.4982	29	2	1	1816	0	2	4
D-F	-59.153	7.3167	-295.839	-347.6754	114	10	7	12426	0	19	20
E-G	-46.0897	26.5394	-300.687	-320.2372	114	12	7	12524	0	19	20
E-H	-34.6952	25.4193	-302.505	-311.7809	114	11	7	12623	0	19	22
E-I	0.0	1.2511	-30.0833	-28.8322	31	3	1	1850	0	2	3
E-L	0.0	0.0	-0.0007	-0.0007	2	0	0	2	0	0	7
F-H	0.0	-8.1162	-13.3898	-21.506	35	0	0	1230	1	19	19
F-K	0.0	-20.048	-4.0391	-24.0871	13	0	0	431	0	16	11
G-H	-33.3373	25.3124	-296.215	-304.2399	112	7	7	12382	0	19	19
G-J	0.0	0.0	-0.0124	-0.0124	4	0	0	10	0	0	9
G-L	0.0	1.2701	-37.6459	-36.3758	35	1	1	1789	0	2	2
H-I	0.0	0.0	-0.0443	-0.0443	6	0	0	10	0	2	9
H-J	0.0	1.2279	-50.6473	-49.4194	34	4	1	2044	0	2	4
I-J	-44.1042	7.8739	-295.48	-331.7103	115	9	7	12490	0	19	20
I-L	-56.7743	26.1467	-290.088	-320.7156	113	9	7	12267	0	19	19
J-L	-61.6217	26.5846	-311.862	-346.8991	116	17	7	12778	0	21	22

Interface residues

• A-D: ASN120A, ASP122A, LYS43D
• A-F: ARG80A, ASN67A, ASP143F, ASP192F, ASP213F, ASP214F, ASP300A, GLU193F, GLU212F, GLU302A, GLU65A, GLY146F, GLY147F, GLY215F, GLY304A, GLY305A, GLY306A, GLY44A, ILE301A, ILE40A, LEU189F, LEU211F, LEU45A, LYS145F, LYS194F, LYS42A, LYS43A, LYS96F, PHE69A, PRO169F, SER144F, SER41A, VAL195F, VAL216F
• A-K: ALA203A, ALA20K, ALA210K, ALA223K, ARG154A, ARG205A, ARG205K, ARG208K, ARG255A, ARG262K, ARG274A, ASN159A, ASN180A, ASN180K, ASN185A, ASN18K, ASN204A, ASN260K, ASN88A, ASP107A, ASP138A, ASP275A, CYS136A, GLN179K, GLN219K, GLN253A, GLN268A, GLU200A, GLU200K, GLU233A, GLU26A, GLU26K, GLU276A, GLU28A, GLU28K, GLU302A, GLY106A, GLY155A, GLY15K, GLY162K, GLY163K, GLY222K, GLY231A, GLY234A, GLY252A, GLY254A, GLY263K, GLY273A, GLY277A, HIS207K, HIS232A, HIS278A, ILE177K, ILE178K, ILE181K, ILE209K, ILE218K, ILE225A, ILE225K, ILE23K, ILE24A, ILE24K, ILE269A, ILE271A, LEU105A, LEU206K, LEU257A, LEU270A, LEU280A, LEU29A, LYS109A, LYS16K, LYS261K, PHE108A, PHE153A, PHE221K, PHE229A, PHE259K, PHE64A, PRO160A, PRO160K, PRO220K, PRO226K, PRO22K, PRO235A, PRO265K, SER157A, SER182A, SER182K, SER19K, SER25A, SER25K, SER27A, SER27K, THR158A, THR201A, THR202A, THR217K, THR224K, THR230A, THR31A, TRP197K, TYR156A, TYR227A, TYR227K, TYR228A, TYR228K, TYR251A, TYR264K, VAL183A, VAL195K, VAL21K, VAL256A, VAL63A
• B-C: ASP126B, ASP130B, GLN320C, GLU129B, HIS85B, LEU131B, LYS317C, LYS86B, SER132B, SER242C
• B-E: ALA134E, ARG154E, ASN159E, ASP192B, ASP213B, GLN179E, LEU161E, LYS194B
• B-F: ARG80B, ASN123F, ASP122F, GLU77B, GLY121F, ILE78B, LEU124F, LYS79B
• B-G: ALA134G, ARG154G, ARG172B, ASN159G, ASN180G, ASP130G, ASP170B, ASP97B, GLN179G, GLY112G, GLY146B, HIS95B, LEU131G, LEU161G, LYS109G, LYS145B, LYS96B, PRO160G, PRO169B, SER110G, SER132G, THR111G, THR133G, THR158G, THR173B, TYR135G, TYR156G, TYR165G
• B-H: ALA134H, ARG154H, ARG172H, ARG54B, ARG99B, ASN120B, ASN159H, ASN180H, ASN72B, ASP107H, ASP152H, ASP53B, ASP97B, CYS136H, GLN179H, GLN320B, GLN323B, GLN325B, GLN55B, GLN57B, GLU119B, GLU129H, GLU74B, GLU77B, GLY162H, GLY163H, GLY290B, GLY56B, GLY98B, HIS95B, ILE127H, ILE128H, ILE137H, ILE177H, ILE178H, ILE181H, ILE288B, LEU131H, LEU161H, LYS109H, LYS145B, LYS317B, LYS70B, LYS79B, LYS96B, PHE150H, PHE171H, PHE322B, PHE324B, PHE52B, PRO160H, PRO176H, PRO289B, PRO73B, SER110H, SER132H, SER144B, THR111H, THR118B, THR133H, THR173H, THR175H, THR291B, THR75B, TYR135H, TYR165H, TYR166H, VAL167H, VAL174H
• B-K: ALA87B, ARG281B, ARG54K, ASN299B, ASN67B, ASN72K, ASN88B, ASP107B, ASP300B, ASP53K, GLN320K, GLN46B, GLN55K, GLN57K, GLN5K, GLN6K, GLU302B, GLU39B, GLU65B, GLU74K, GLU77K, GLY290K, GLY304B, GLY305B, GLY306B, GLY44B, GLY56K, ILE288K, ILE301B, ILE71K, LEU45B, LYS317K, LYS42B, LYS43B, LYS70K, LYS79K, PHE108B, PHE287K, PHE324K, PHE52K, PHE64B, PRO289K, PRO73K, SER307B, SER41B, THR291K, THR75K, VAL83B
• C-F: ARG172F, GLN6C
• C-G: ARG54C, ARG99C, ASN123C, ASP107G, ASP122C, ASP126G, ASP130G, ASP97C, GLN125C, GLN325C, GLN55C, GLU129G, GLY121G, GLY98C, HIS85G, LEU124G, LEU131G, LYS86G, LYS96C, PHE82G, SER132G, SER84G, THR111G, THR118C, VAL83G
• C-K: ASN18C, ASN18K, GLN30C, GLN30K, GLU28C, GLU28K, GLY15C, GLY15K, ILE32C, ILE32K, LEU11C, LEU11K, LEU8K, LYS16C, LYS16K, PHE12C, PHE12K, PRO9C, PRO9K, SER14C, SER14K, SER17C, SER17K, THR10C, THR10K, THR31C, THR31K, TYR13C, TYR13K
• D-F: ALA203D, ALA20F, ALA210F, ALA223F, ARG154D, ARG205D, ARG205F, ARG208F, ARG255D, ARG262F, ARG274D, ASN159D, ASN180D, ASN180F, ASN185D, ASN18F, ASN204D, ASN260F, ASN88D, ASP107D, ASP275D, CYS136D, GLN179F, GLN219F, GLN253D, GLN268D, GLN46D, GLU200D, GLU200F, GLU233D, GLU26D, GLU26F, GLU276D, GLU28D, GLU28F, GLU302D, GLY155D, GLY15F, GLY162F, GLY163F, GLY222F, GLY231D, GLY234D, GLY252D, GLY254D, GLY263F, GLY273D, GLY277D, HIS207F, HIS232D, HIS278D, ILE177F, ILE178F, ILE181F, ILE209F, ILE218F, ILE225D, ILE225F, ILE23F, ILE24F, ILE269D, ILE271D, LEU105D, LEU206F, LEU257D, LEU270D, LEU280D, LEU29D, LYS109D, LYS16F, LYS261F, PHE108D, PHE153D, PHE221F, PHE229D, PHE259F, PHE64D, PRO160D, PRO160F, PRO176F, PRO220F, PRO226F, PRO22F, PRO235D, PRO265F, SER157D, SER182D, SER182F, SER19F, SER25D, SER25F, SER27D, SER27F, THR158D, THR201D, THR202D, THR217F, THR224F, THR230D, THR31D, TRP197F, TYR156D, TYR227D, TYR227F, TYR228D, TYR228F, TYR251D, TYR264F, VAL164F, VAL183D, VAL195F, VAL21F, VAL256D, VAL63D
• E-G: ALA203E, ALA20G, ALA210G, ALA223G, ARG154E, ARG205E, ARG205G, ARG208G, ARG255E, ARG262G, ARG274E, ASN159E, ASN180E, ASN180G, ASN185E, ASN18G, ASN204E, ASN260G, ASN88E, ASP107E, ASP275E, CYS136E, GLN179G, GLN219G, GLN253E, GLN268E, GLN46E, GLU200E, GLU200G, GLU233E, GLU26E, GLU26G, GLU276E, GLU28E, GLU28G, GLU302E, GLY155E, GLY15G, GLY162G, GLY163G, GLY222G, GLY231E, GLY234E, GLY252E, GLY254E, GLY263G, GLY273E, GLY277E, HIS207G, HIS232E, HIS278E, ILE177G, ILE178G, ILE181G, ILE209G, ILE218G, ILE225E, ILE225G, ILE23G, ILE24E, ILE24G, ILE269E, ILE271E, LEU105E, LEU206E, LEU206G, LEU257E, LEU270E, LEU280E, LEU29E, LYS109E, LYS16G, LYS261G, PHE108E, PHE153E, PHE221G, PHE229E, PHE259G, PHE64E, PRO160E, PRO160G, PRO220G, PRO226G, PRO22G, PRO235E, PRO265G, SER157E, SER182E, SER182G, SER19G, SER25E, SER25G, SER27E, SER27G, THR158E, THR201E, THR202E, THR217G, THR224G, THR230E, THR31E, TRP197G, TYR156E, TYR227E, TYR227G, TYR228E, TYR228G, TYR251E, TYR264G, VAL183E, VAL195G, VAL21G, VAL256E, VAL63E
• E-H: ALA203H, ALA20E, ALA210E, ALA223E, ARG154H, ARG205E, ARG205H, ARG208E, ARG255H, ARG262E, ARG274H, ASN159H, ASN180E, ASN180H, ASN185H, ASN18E, ASN204H, ASN260E, ASN88H, ASP107H, ASP275H, GLN179E, GLN219E, GLN253H, GLN268H, GLN46H, GLU200E, GLU200H, GLU233H, GLU26E, GLU26H, GLU276H, GLU28E, GLU28H, GLU302H, GLY155H, GLY15E, GLY162E, GLY163E, GLY222E, GLY231H, GLY234H, GLY252H, GLY254H, GLY263E, GLY273H, GLY277H, HIS207E, HIS232H, HIS278H, ILE177E, ILE178E, ILE181E, ILE209E, ILE218E, ILE225E, ILE225H, ILE23E, ILE24E, ILE24H, ILE269H, ILE271H, LEU105H, LEU206E, LEU257H, LEU270H, LEU280H, LEU29H, LYS109H, LYS16E, LYS261E, PHE108H, PHE153H, PHE221E, PHE229H, PHE259E, PHE64H, PRO160E, PRO160H, PRO176E, PRO220E, PRO226E, PRO22E, PRO235H, PRO265E, SER157H, SER182E, SER182H, SER19E, SER25E, SER25H, SER27E, SER27H, SER282H, THR158H, THR201H, THR202H, THR217E, THR224E, THR230H, THR31H, TRP197E, TYR156H, TYR227E, TYR227H, TYR228E, TYR228H, TYR251H, TYR264E, VAL183H, VAL195E, VAL21E, VAL256H, VAL63H
• E-I: ASN18E, ASN18I, ASP7I, GLN30E, GLN30I, GLU28E, GLU28I, GLY15E, GLY15I, ILE32E, ILE32I, LEU11E, LEU11I, LEU29E, LEU8I, LYS16E, LYS16I, PHE12E, PHE12I, PRO9E, PRO9I, SER14E, SER14I, SER17E, SER17I, THR10E, THR10I, THR31E, THR31I, TYR13E, TYR13I
• E-L: GLN6L, GLU276E
• F-H: ALA87F, ARG172H, ARG54H, ARG99H, ASN123H, ASN88F, ASP107F, ASP122H, ASP130F, ASP170H, ASP97H, GLN125H, GLN325H, GLU65F, GLY106F, GLY121F, GLY146H, GLY147H, HIS85F, HIS95H, LEU124F, LEU131F, LYS109F, LYS145H, LYS43F, LYS86F, LYS96H, PHE108F, PHE322H, PHE324H, PHE64F, PRO169H, SER110F, SER144H, THR111F
• F-K: ARG54F, ASP192K, ASP213K, ASP97F, GLN320F, GLN325F, GLN55F, GLU193K, LYS145K, LYS194K, LYS96F, PHE324F, SER144K
• G-H: ALA203G, ALA20H, ALA210H, ALA223H, ARG154G, ARG205G, ARG205H, ARG208H, ARG255G, ARG262H, ARG274G, ASN159G, ASN180G, ASN180H, ASN18H, ASN204G, ASN260H, ASN88G, ASP107G, ASP275G, CYS136G, GLN179H, GLN219H, GLN253G, GLN268G, GLN46G, GLU200G, GLU200H, GLU233G, GLU26G, GLU26H, GLU276G, GLU28G, GLU28H, GLU302G, GLY155G, GLY15H, GLY162H, GLY163H, GLY222H, GLY231G, GLY234G, GLY252G, GLY254G, GLY263H, GLY273G, GLY277G, HIS207H, HIS232G, HIS278G, ILE177H, ILE178H, ILE181H, ILE209H, ILE218H, ILE225G, ILE225H, ILE23H, ILE24G, ILE24H, ILE269G, ILE271G, LEU105G, LEU206H, LEU257G, LEU270G, LEU280G, LEU29G, LYS109G, LYS16H, LYS261H, PHE108G, PHE153G, PHE221H, PHE229G, PHE259H, PHE64G, PRO160G, PRO160H, PRO220H, PRO226H, PRO22H, PRO235G, PRO265H, SER157G, SER182G, SER182H, SER19H, SER25G, SER25H, SER27G, SER27H, THR158G, THR201G, THR202G, THR217H, THR224H, THR230G, THR31G, TRP197H, TYR156G, TYR227G, TYR227H, TYR228G, TYR228H, TYR251G, TYR264H, VAL183G, VAL195H, VAL21H, VAL256G, VAL63G
• G-J: GLN6G, GLU276G, GLU276J, GLU35J
• G-L: ALA316G, ASN18G, ASN18L, ASP243G, ASP243L, ASP7G, GLN30G, GLN30L, GLN5L, GLN6G, GLN6L, GLU28G, GLU28L, GLY15G, GLY15L, ILE32G, ILE32L, LEU11G, LEU11L, LYS16G, LYS16L, PHE12G, PHE12L, PRO9G, PRO9L, SER14G, SER14L, SER17L, THR10G, THR10L, THR31G, THR31L, THR33G, TYR13G, TYR13L
• H-I: ASP7H, GLU276H, GLU276I, GLU35H, GLU35I, THR33H
• H-J: ASN18H, ASN18J, ASP7H, GLN30H, GLN30J, GLU28H, GLU28J, GLY15H, GLY15J, ILE32H, ILE32J, LEU11H, LEU11J, LEU29H, LEU29J, LEU8H, LYS16H, LYS16J, PHE12H, PHE12J, PHE315H, PHE315J, PRO9H, PRO9J, SER14H, SER14J, SER17H, SER17J, THR10H, THR10J, THR31H, THR31J, TYR13H, TYR13J
• I-J: ALA203I, ALA20J, ALA210J, ALA223J, ARG154I, ARG205I, ARG205J, ARG208J, ARG255I, ARG262J, ARG274I, ARG281I, ASN159I, ASN180I, ASN180J, ASN185I, ASN18J, ASN204I, ASN260J, ASN88I, ASP107I, ASP275I, CYS136I, GLN179J, GLN219J, GLN253I, GLN268I, GLN46I, GLU200I, GLU200J, GLU233I, GLU26I, GLU26J, GLU276I, GLU28I, GLU28J, GLU302I, GLY155I, GLY15J, GLY162J, GLY163J, GLY222J, GLY231I, GLY234I, GLY252I, GLY254I, GLY263J, GLY273I, GLY277I, HIS207J, HIS232I, HIS278I, ILE177J, ILE178J, ILE181J, ILE209J, ILE218J, ILE225I, ILE225J, ILE23J, ILE24J, ILE269I, ILE271I, LEU105I, LEU206J, LEU257I, LEU270I, LEU280I, LEU29I, LYS109I, LYS16J, LYS261J, PHE108I, PHE153I, PHE221J, PHE229I, PHE259J, PHE64I, PRO160I, PRO160J, PRO176J, PRO220J, PRO226J, PRO22J, PRO235I, PRO265J, SER157I, SER182I, SER182J, SER19J, SER25I, SER25J, SER27I, SER27J, THR158I, THR201I, THR202I, THR217J, THR224J, THR230I, THR31I, TRP197J, TYR156I, TYR227J, TYR228I, TYR228J, TYR251I, TYR264J, VAL164J, VAL183I, VAL195J, VAL198J, VAL21J, VAL256I, VAL63I
• I-L: ALA203L, ALA20I, ALA210I, ALA223I, ARG154L, ARG205I, ARG205L, ARG208I, ARG255L, ARG262I, ARG274L, ASN159L, ASN180I, ASN180L, ASN18I, ASN204L, ASN260I, ASN88L, ASP107L, ASP275L, CYS136L, GLN179I, GLN219I, GLN253L, GLN268L, GLN46L, GLU200I, GLU200L, GLU233L, GLU26I, GLU26L, GLU276L, GLU28I, GLU28L, GLU302L, GLY155L, GLY15I, GLY162I, GLY163I, GLY222I, GLY231L, GLY234L, GLY252L, GLY254L, GLY263I, GLY273L, GLY277L, HIS207I, HIS232L, HIS278L, ILE177I, ILE178I, ILE181I, ILE209I, ILE218I, ILE225I, ILE225L, ILE23I, ILE24I, ILE269L, ILE271L, LEU105L, LEU206I, LEU257L, LEU270L, LEU280L, LEU29L, LYS109L, LYS16I, LYS261I, PHE108L, PHE153L, PHE221I, PHE229I, PHE229L, PHE259I, PHE64L, PRO160I, PRO160L, PRO220I, PRO226I, PRO22I, PRO235L, PRO265I, SER157L, SER182I, SER182L, SER19I, SER25I, SER25L, SER27I, SER27L, THR158L, THR201L, THR202L, THR217I, THR224I, THR230L, THR31L, TRP197I, TYR156L, TYR227I, TYR227L, TYR228I, TYR228L, TYR251L, TYR264I, VAL164I, VAL183L, VAL195I, VAL21I, VAL256L, VAL63L
• J-L: ALA203J, ALA20L, ALA210L, ALA223L, ARG154J, ARG205J, ARG205L, ARG208L, ARG255J, ARG262L, ARG274J, ASN159J, ASN180J, ASN180L, ASN185J, ASN18L, ASN204J, ASN260L, ASN88J, ASP107J, ASP275J, CYS136J, GLN179L, GLN219L, GLN253J, GLN268J, GLN46J, GLU200J, GLU200L, GLU233J, GLU26J, GLU26L, GLU276J, GLU28J, GLU28L, GLU302J, GLY106J, GLY155J, GLY15L, GLY162L, GLY163L, GLY222L, GLY231J, GLY234J, GLY252J, GLY254J, GLY263L, GLY273J, GLY277J, HIS207L, HIS232J, HIS278J, ILE177L, ILE178L, ILE181L, ILE209L, ILE218L, ILE225J, ILE225L, ILE23L, ILE24J, ILE24L, ILE269J, ILE271J, LEU105J, LEU206L, LEU257J, LEU270J, LEU280J, LEU29J, LYS109J, LYS16L, LYS261L, PHE108J, PHE153J, PHE221L, PHE229J, PHE229L, PHE259L, PHE64J, PRO160J, PRO160L, PRO220L, PRO226L, PRO22L, PRO235J, PRO265L, SER157J, SER182J, SER182L, SER19L, SER25J, SER25L, SER27J, SER27L, THR158J, THR201J, THR202J, THR217L, THR224L, THR230J, THR31J, TRP197L, TYR156J, TYR227J, TYR227L, TYR228J, TYR228L, TYR251J, TYR264L, VAL164L, VAL183J, VAL195L, VAL21L, VAL256J, VAL63J