2DFD

crystal structure of human malate dehydrogenase type 2

• Total interactions analyzed: 6
• Total true interactions: 6
• Strongest Interaction:
  • Chains: A-B
  • Int. Res.: 168
  • Norm. En. per Res.: -3.8179
• Hub Node: A(3)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-115.362	-66.4799	-459.57	-641.4119	168	13	16	18258	6	41	39
A-C	0.0	0.0	-0.0138	-0.0138	4	0	0	10	0	0	1
A-D	-6.6473	17.3449	-95.5405	-84.8429	55	3	0	4007	0	13	10
B-C	-22.6417	20.0506	-98.4476	-101.0387	54	2	0	3965	0	11	10
B-D	0.0	0.0	-0.1244	-0.1244	4	0	0	26	0	0	1
C-D	-94.2501	-68.8114	-468.056	-631.1175	167	13	16	18353	6	41	40

Interface residues

• A-B: ALA14A, ALA14B, ALA159A, ALA159B, ALA164A, ALA164B, ALA172A, ALA172B, ALA215A, ALA215B, ALA222A, ALA222B, ALA224A, ALA224B, ALA226A, ALA226B, ALA229A, ALA229B, ALA234A, ALA234B, ALA236A, ALA236B, ALA238A, ALA238B, ALA41A, ALA47A, ALA47B, ALA48A, ALA48B, ALA57A, ALA57B, ALA58A, ALA58B, ARG158A, ARG158B, ARG173A, ARG173B, ARG211A, ARG211B, ARG239A, ARG239B, ASN160A, ASN160B, ASN175A, ASN175B, ASN28A, ASN28B, ASP155A, ASP155B, ASP170A, ASP170B, ASP49A, ASP49B, GLN20A, GLN20B, GLU165A, GLU165B, GLU214A, GLU214B, GLU218A, GLU218B, GLU256B, GLU54A, GLU54B, GLY16A, GLY16B, GLY17A, GLY17B, GLY19A, GLY19B, GLY216A, GLY216B, GLY225A, GLY225B, GLY227A, GLY227B, GLY45A, GLY45B, HIS42A, HIS42B, HIS52A, HIS52B, ILE156A, ILE156B, ILE18A, ILE18B, ILE212A, ILE212B, ILE53A, ILE53B, LEU154A, LEU154B, LEU169A, LEU169B, LEU22A, LEU22B, LEU231A, LEU231B, LEU24A, LEU24B, LEU25A, LEU25B, LEU35A, LEU35B, LEU37A, LEU37B, LEU50A, LEU50B, LYS221A, LYS221B, LYS223A, LYS223B, LYS27A, LYS27B, LYS56A, LYS56B, MET233A, MET233B, PHE162A, PHE162B, PHE242A, PHE242B, PRO171A, PRO171B, PRO21A, PRO21B, PRO30A, PRO30B, PRO44A, PRO44B, SER15A, SER15B, SER228A, SER228B, SER232A, SER232B, SER23A, SER23B, SER51A, SER51B, THR153A, THR153B, THR161A, THR161B, THR217A, THR217B, THR230A, THR230B, THR43A, THR43B, THR55A, THR55B, TYR235A, TYR235B, VAL157A, VAL157B, VAL174A, VAL174B, VAL176A, VAL176B, VAL219A, VAL219B, VAL220A, VAL220B, VAL46A, VAL46B, VAL59A, VAL59B
• A-C: ALA41A, ALA41C, HIS42A, HIS42C
• A-D: ALA100A, ALA100D, ALA224A, ALA224D, ALA226A, ALA41D, ARG86A, ARG86D, ARG92A, ARG92D, ASN97A, ASN97D, ASN99A, ASN99D, ASP93A, ASP93D, ASP94A, ASP94D, GLY225A, GLY225D, GLY83A, GLY83D, GLY89A, GLY89D, HIS42D, ILE102A, ILE102D, ILE40A, ILE40D, LEU95A, LEU95D, LYS221A, LYS311A, LYS311D, LYS87A, LYS87D, MET90A, MET90D, PHE315A, PHE96A, PHE96D, PRO85A, PRO85D, PRO88A, PRO88D, THR101A, THR101D, THR91A, THR91D, THR98A, THR98D, VAL220A, VAL220D, VAL84A, VAL84D
• B-C: ALA100B, ALA100C, ALA224B, ALA224C, ALA226C, ALA41B, ARG86B, ARG86C, ARG92B, ARG92C, ASN97B, ASN97C, ASN99B, ASN99C, ASP93B, ASP93C, ASP94B, ASP94C, GLY225B, GLY225C, GLY83B, GLY83C, GLY89B, GLY89C, HIS42B, ILE102B, ILE102C, ILE40B, ILE40C, LEU95B, LEU95C, LYS311B, LYS311C, LYS87B, LYS87C, MET90B, MET90C, PHE315C, PHE96B, PHE96C, PRO85B, PRO85C, PRO88B, PRO88C, THR101B, THR101C, THR91B, THR91C, THR98B, THR98C, VAL220B, VAL220C, VAL84B, VAL84C
• B-D: ALA41B, ALA41D, HIS42B, HIS42D
• C-D: ALA14C, ALA14D, ALA159C, ALA159D, ALA164C, ALA164D, ALA172C, ALA172D, ALA215C, ALA215D, ALA222C, ALA222D, ALA224C, ALA224D, ALA226C, ALA226D, ALA229C, ALA229D, ALA234C, ALA234D, ALA236C, ALA236D, ALA238C, ALA238D, ALA41C, ALA47C, ALA47D, ALA48C, ALA48D, ALA57C, ALA57D, ALA58C, ALA58D, ARG158C, ARG158D, ARG173C, ARG173D, ARG211C, ARG211D, ARG239C, ARG239D, ASN160C, ASN160D, ASN175C, ASN175D, ASN28C, ASN28D, ASP155C, ASP155D, ASP170C, ASP170D, ASP49C, ASP49D, GLN20C, GLN20D, GLU165C, GLU165D, GLU214C, GLU214D, GLU218C, GLU218D, GLU54C, GLU54D, GLY16C, GLY16D, GLY17C, GLY17D, GLY19C, GLY19D, GLY216C, GLY216D, GLY225C, GLY225D, GLY227C, GLY227D, GLY45C, GLY45D, HIS42C, HIS42D, HIS52C, HIS52D, ILE156C, ILE156D, ILE18C, ILE18D, ILE212C, ILE212D, ILE53C, ILE53D, LEU154C, LEU154D, LEU169C, LEU169D, LEU22C, LEU22D, LEU231C, LEU231D, LEU24C, LEU24D, LEU25C, LEU25D, LEU35C, LEU35D, LEU37C, LEU37D, LEU50C, LEU50D, LYS221C, LYS221D, LYS223C, LYS223D, LYS27C, LYS27D, LYS56C, LYS56D, MET233C, MET233D, PHE162C, PHE162D, PHE242C, PHE242D, PRO171C, PRO171D, PRO21C, PRO21D, PRO30C, PRO30D, PRO44C, PRO44D, SER15C, SER15D, SER228C, SER228D, SER232C, SER232D, SER23C, SER23D, SER51C, SER51D, THR153C, THR153D, THR161C, THR161D, THR217C, THR217D, THR230C, THR230D, THR43C, THR43D, THR55C, THR55D, TYR235C, TYR235D, VAL157C, VAL157D, VAL174C, VAL174D, VAL176C, VAL176D, VAL219C, VAL219D, VAL220C, VAL220D, VAL46C, VAL46D, VAL59C, VAL59D