2DF7

crystal structure of infectious bursal disease virus vp2 subviral particle

• Total interactions analyzed: 190
• Total true interactions: 43
• Strongest Interaction:
  • Chains: I-J
  • Int. Res.: 224
  • Norm. En. per Res.: -3.5038
• Hub Node: C(6)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-26.7142	-9.3333	-222.652	-258.6996	120	23	5	10497	3	19	19
A-D	0.0	0.0	-0.0073	-0.0073	2	0	0	1	0	0	0
A-F	-207.235	114.4849	-664.999	-757.7492	224	32	23	26537	10	54	60
A-L	0.0	0.0	-24.5528	-24.5528	12	1	1	713	0	0	0
A-T	-27.7878	16.1693			13
B-D	-35.1525	19.9722	-201.904	-217.0843	114	7	2	9142	2	19	20
B-L	0.0	0.0	-17.6764	-17.6764	10	0	1	372	0	0	0
C-E	-183.8232	113.5171	-640.205	-710.5111	224	38	22	26177	11	49	59
C-L	-217.2437	120.5674	-662.235	-758.9113	226	31	22	26346	11	51	60
C-M	0.0	0.0	-0.0007	-0.0007	2	0	0	2	0	0	0
C-N	-21.4086	9.5557	-150.251	-162.1038	103	19	1	7805	2	19	18
C-O	-26.9106	0.0	-94.6097	-121.5203	47	6	1	3779	0	8	5
C-R	-13.6444	25.0729			9
D-E	-29.1752	0.0	-87.951	-117.1262	50	9	1	3907	0	8	5
D-L	-28.7596	25.2037	-171.395	-174.9509	111	19	3	9228	1	20	20
E-L	-176.1007	122.2527	-633.433	-687.281	224	31	21	26224	9	50	61
E-O	-15.4245	1.3217	-183.725	-197.8278	109	7	2	8672	0	19	20
F-S	-20.55	15.2014			12
F-T	-28.2046	0.0			6
G-K	-187.3184	108.3352	-643.278	-722.2612	228	38	22	26658	8	52	61
G-M	-229.7571	110.5995	-665.153	-784.3106	226	31	22	26783	10	52	61
G-S	-16.7724	4.5999			14
H-I	-8.7388	13.9659	-173.329	-168.1018	112	10	2	8581	2	19	20
H-N	-218.7348	114.012	-638.855	-743.5778	224	37	20	26109	10	51	61
H-O	-209.529	116.1835	-671.705	-765.0505	227	31	23	26620	10	53	62
I-J	-226.87	114.8738	-672.855	-784.8512	224	34	20	26526	11	51	60
I-N	-19.8422	0.0	-96.9952	-116.8374	47	4	1	3750	0	8	5
I-Q	-202.7254	121.2651	-1.4445	-82.9048	63	0	0	113	0	0	4
J-K	-10.6817	-17.1808	-179.993	-207.8555	111	10	2	8838	4	19	20
J-P	-15.9395	6.5231	-174.7	-184.1164	105	9	1	8117	3	19	19
J-Q	-220.6645	127.9193	-7.4139	-100.1591	62	1	0	271	0	1	3
K-M	-180.4828	107.9654	-636.207	-708.7243	224	35	21	26223	11	52	61
K-Q	-25.2964	0.0	-0.0259	-25.3223	8	0	0	17	0	0	0
L-R	-25.5131	0.0			6
L-T	-26.6271	-1.2375			13
M-Q	-9.1304	-7.0362	-26.994	-43.1606	32	6	0	1507	0	2	2
M-R	-14.06	1.7754			10
M-S	-28.4205	0.0			6
N-O	-221.9594	121.9673	-656.49	-756.4821	227	32	22	26417	10	50	60
N-Q	-11.3488	-1.3433	0.0	-12.6921	12	0	0	0	0	0	0
R-S	-203.0534	108.1833			58
R-T	-185.0189	123.3644			57
S-T	-195.945	115.9041			59

Interface residues

• A-B: ALA119A, ALA119B, ALA126B, ALA147B, ALA149B, ALA358B, ALA366A, ALA430A, ALA89A, ARG109A, ARG16A, ARG356B, ARG389A, ARG39A, ARG405B, ARG407B, ARG417A, ARG417B, ARG423A, ASN121A, ASN121B, ASN125B, ASN142B, ASN150B, ASN152B, ASN157B, ASN370A, ASN46A, ASN91A, ASP391A, ASP421B, GLN84A, GLN90A, GLU162B, GLU355B, GLU404B, GLU406B, GLU418B, GLU41A, GLU424A, GLU428A, GLU428B, GLY115A, GLY115B, GLY116A, GLY116B, GLY122B, GLY143B, GLY156B, GLY161A, GLY161B, GLY24A, GLY360A, GLY367A, GLY409B, ILE11A, ILE124B, ILE151B, ILE155B, ILE410B, LEU113A, LEU113B, LEU120A, LEU120B, LEU144B, LEU159B, LEU383A, LEU38A, LEU408B, LEU47A, LYS154B, LYS411B, MET145B, MET427A, PHE14A, PRO114A, PRO114B, PRO13A, PRO21A, PRO25A, PRO415B, SER110A, SER111A, SER146B, SER361A, SER369A, SER40A, SER43A, THR107A, THR112A, THR123B, THR148B, THR22A, THR23A, THR364A, THR420A, THR42A, THR44A, THR48A, THR88A, TYR118A, TYR118B, TYR141B, TYR354B, TYR425B, TYR45A, TYR96A, VAL117A, VAL117B, VAL12A, VAL158B, VAL160A, VAL160B, VAL357B, VAL362A, VAL363A, VAL365A, VAL368A, VAL429B, VAL49A
• A-D: LEU113D, TYR118A
• A-F: ALA147A, ALA149A, ALA186F, ALA195F, ALA210A, ALA211A, ALA232A, ALA256F, ALA259F, ALA275F, ALA277F, ALA329A, ALA334A, ALA380F, ALA394F, ARG100F, ARG179F, ARG202A, ARG202F, ARG204A, ARG274F, ARG347A, ARG389F, ARG405A, ARG407A, ASN150A, ASN152A, ASN233A, ASN280F, ASN288A, ASN293A, ASN293F, ASN299F, ASN341A, ASN376F, ASN382F, ASN396A, ASN396F, ASN97F, ASP138A, ASP153A, ASP174A, ASP174F, ASP182F, ASP190F, ASP198F, ASP201A, ASP201F, ASP212A, ASP213A, ASP235A, ASP258F, ASP279F, ASP287A, ASP30A, ASP30F, ASP31A, ASP31F, ASP391F, CYS197F, CYS99F, GLN130A, GLN215A, GLU135A, GLU245A, GLU300F, GLU34F, GLU378F, GLU386F, GLU404A, GLU406A, GLY131A, GLY143A, GLY176F, GLY181F, GLY188F, GLY243A, GLY243F, GLY244A, GLY285A, GLY331A, GLY339A, GLY339F, GLY340A, GLY344A, GLY388F, GLY393A, GLY393F, HIS249A, HIS338F, HIS36F, ILE151A, ILE184F, ILE187F, ILE208A, ILE227A, ILE234A, ILE242A, ILE242F, ILE286A, ILE28A, ILE28F, ILE296F, ILE308A, ILE312A, ILE337A, ILE374F, ILE401A, ILE410A, LEU136A, LEU144A, LEU169A, LEU175A, LEU175F, LEU180F, LEU189F, LEU18A, LEU229A, LEU240F, LEU246A, LEU289A, LEU294F, LEU310A, LEU333A, LEU33F, LEU346A, LEU373F, LEU379F, LEU383F, LEU400A, LEU402A, LYS154A, LYS192F, LYS309A, LYS35F, LYS381F, LYS399A, LYS399F, LYS411A, MET145A, MET193F, MET290A, MET290F, MET395A, MET395F, PHE129A, PHE14A, PHE216A, PHE230A, PHE292A, PHE292F, PHE390F, PRO170A, PRO183F, PRO185F, PRO191F, PRO203A, PRO203F, PRO291A, PRO291F, PRO297F, PRO29A, PRO29F, PRO343A, PRO348A, PRO375F, PRO377F, PRO392F, SER132A, SER134A, SER146A, SER168A, SER172A, SER199F, SER200A, SER200F, SER217A, SER231A, SER239F, SER241F, SER278F, SER307A, SER330A, SER332A, SER403A, THR128A, THR137A, THR148A, THR171A, THR196F, THR207A, THR209A, THR226A, THR228A, THR260F, THR283A, THR298F, THR306A, THR32A, THR32F, THR336A, THR336F, THR37F, THR385F, THR398A, THR412A, TRP327A, TYR173A, TYR177F, TYR206A, TYR214A, TYR342A, TYR342F, TYR387F, TYR397A, TYR98F, VAL178F, VAL194F, VAL205A, VAL247A, VAL276F, VAL295F, VAL335A, VAL384F
• A-L: ALA119A, ALA119L, GLY115L, GLY116A, GLY116L, LEU113L, LEU120L, PRO114L, TYR118A, TYR118L, VAL117A, VAL117L
• A-T: ARG109T, ARG16T, ARG407A, ARG423T, ASN142A, ASP421A, GLU162A, GLU424T, GLY115T, LEU113T, LEU120A, THR44T, TYR118A
• B-D: ALA119B, ALA126D, ALA147D, ALA149D, ALA26B, ALA358B, ALA358D, ALA366B, ALA89B, ARG109B, ARG16B, ARG356D, ARG389B, ARG39B, ARG405D, ARG407D, ARG417B, ARG417D, ARG423B, ASN121B, ASN121D, ASN125D, ASN142D, ASN150D, ASN152D, ASN157D, ASN370B, ASN46B, ASN91B, ASP391B, ASP421D, GLN84B, GLN90B, GLU162B, GLU162D, GLU355D, GLU404D, GLU406D, GLU418D, GLU41B, GLU424B, GLU428B, GLU428D, GLY115B, GLY122D, GLY143D, GLY156D, GLY161B, GLY161D, GLY24B, GLY360B, GLY367B, GLY409D, ILE124D, ILE151D, ILE155D, ILE410D, LEU113B, LEU120B, LEU120D, LEU144D, LEU159D, LEU38B, LEU408D, LEU47B, LYS154D, LYS411D, MET145D, MET427B, PHE14B, PHE422D, PRO114B, PRO13B, PRO21B, PRO25B, PRO415D, SER110B, SER111B, SER146D, SER17B, SER361B, SER369B, SER40B, SER43B, THR107B, THR112B, THR123D, THR148D, THR22B, THR23B, THR364B, THR420B, THR42B, THR44B, THR48B, THR88B, TYR118B, TYR141D, TYR354D, TYR425D, TYR45B, TYR96B, VAL117B, VAL12B, VAL158D, VAL160B, VAL160D, VAL357B, VAL357D, VAL362B, VAL363B, VAL365B, VAL368B, VAL49B
• B-L: ALA119B, ALA119L, GLY115B, GLY116B, GLY116L, LEU113B, TYR118B, TYR118L, VAL117B, VAL117L
• C-E: ALA147E, ALA149E, ALA186C, ALA195C, ALA210E, ALA211E, ALA232E, ALA259C, ALA275C, ALA277C, ALA329E, ALA334E, ALA380C, ARG100C, ARG179C, ARG202C, ARG202E, ARG204E, ARG274C, ARG347E, ARG389C, ARG405E, ARG407E, ASN150E, ASN152E, ASN233E, ASN280C, ASN288E, ASN293C, ASN293E, ASN299C, ASN341E, ASN376C, ASN382C, ASN396C, ASN396E, ASN97C, ASP138E, ASP153E, ASP174C, ASP174E, ASP182C, ASP190C, ASP198C, ASP201C, ASP201E, ASP212E, ASP213E, ASP235E, ASP258C, ASP279C, ASP287E, ASP30C, ASP30E, ASP31C, ASP31E, ASP391C, CYS197C, CYS99C, GLN130E, GLN215E, GLU135E, GLU245E, GLU300C, GLU34C, GLU378C, GLU386C, GLU404E, GLU406E, GLY131E, GLY143E, GLY176C, GLY181C, GLY188C, GLY243E, GLY244C, GLY244E, GLY285E, GLY331E, GLY339C, GLY339E, GLY340E, GLY344E, GLY388C, GLY393C, GLY393E, HIS249E, HIS338C, HIS36C, ILE151E, ILE184C, ILE187C, ILE208E, ILE227E, ILE234E, ILE242C, ILE242E, ILE286E, ILE28C, ILE28E, ILE296C, ILE308E, ILE312E, ILE337E, ILE374C, ILE401E, ILE410E, LEU136E, LEU144E, LEU169E, LEU175C, LEU175E, LEU180C, LEU189C, LEU18E, LEU229E, LEU240C, LEU246E, LEU289E, LEU294C, LEU310E, LEU333E, LEU33C, LEU346E, LEU373C, LEU379C, LEU383C, LEU400E, LEU402E, LYS154E, LYS192C, LYS309E, LYS35C, LYS381C, LYS399C, LYS399E, LYS411E, MET145E, MET193C, MET290C, MET290E, MET395C, MET395E, PHE129E, PHE14E, PHE216E, PHE230E, PHE292C, PHE292E, PHE390C, PRO170E, PRO183C, PRO185C, PRO191C, PRO203C, PRO203E, PRO291C, PRO291E, PRO297C, PRO29C, PRO29E, PRO343E, PRO348E, PRO375C, PRO377C, PRO392C, SER132E, SER134E, SER146E, SER168E, SER172E, SER199C, SER200C, SER200E, SER217E, SER218E, SER231E, SER239C, SER241C, SER278C, SER307E, SER330E, SER332E, SER403E, THR128E, THR137E, THR148E, THR171E, THR196C, THR207E, THR209E, THR226E, THR228E, THR260C, THR283E, THR298C, THR306E, THR32C, THR32E, THR336C, THR336E, THR37C, THR385C, THR398E, THR412E, TRP327E, TYR173E, TYR177C, TYR206E, TYR214E, TYR342C, TYR342E, TYR387C, TYR397E, TYR98C, VAL178C, VAL194C, VAL205E, VAL247E, VAL276C, VAL295C, VAL335E, VAL349E, VAL384C
• C-L: ALA147C, ALA149C, ALA186L, ALA195L, ALA210C, ALA211C, ALA232C, ALA256L, ALA259L, ALA275L, ALA277L, ALA329C, ALA334C, ALA380L, ALA394L, ARG100L, ARG179L, ARG202C, ARG202L, ARG204C, ARG274L, ARG347C, ARG389L, ARG405C, ASN150C, ASN152C, ASN233C, ASN280L, ASN288C, ASN293C, ASN293L, ASN299L, ASN341C, ASN376L, ASN382L, ASN396C, ASN396L, ASN97L, ASP138C, ASP153C, ASP174C, ASP174L, ASP182L, ASP190L, ASP198L, ASP201C, ASP201L, ASP212C, ASP213C, ASP235C, ASP258L, ASP279L, ASP287C, ASP30C, ASP30L, ASP31C, ASP31L, ASP391L, CYS197L, CYS99L, GLN130C, GLN215C, GLU135C, GLU245C, GLU300L, GLU311C, GLU34L, GLU378L, GLU386L, GLU404C, GLU406C, GLY131C, GLY143C, GLY176L, GLY181L, GLY188L, GLY243C, GLY244C, GLY244L, GLY285C, GLY331C, GLY339C, GLY339L, GLY340C, GLY344C, GLY388L, GLY393C, GLY393L, HIS249C, HIS338L, HIS36L, ILE151C, ILE184L, ILE187L, ILE208C, ILE227C, ILE234C, ILE242C, ILE242L, ILE286C, ILE28C, ILE28L, ILE296L, ILE308C, ILE312C, ILE337C, ILE374L, ILE401C, ILE410C, LEU136C, LEU144C, LEU169C, LEU175C, LEU175L, LEU180L, LEU189L, LEU18C, LEU229C, LEU240L, LEU246C, LEU257L, LEU289C, LEU294C, LEU294L, LEU310C, LEU333C, LEU33L, LEU346C, LEU373L, LEU379L, LEU383L, LEU400C, LEU402C, LYS154C, LYS192L, LYS309C, LYS35L, LYS381L, LYS399C, LYS399L, LYS411C, MET145C, MET193L, MET290C, MET290L, MET395C, MET395L, PHE129C, PHE14C, PHE216C, PHE230C, PHE292C, PHE292L, PHE390L, PRO170C, PRO183L, PRO185L, PRO191L, PRO203C, PRO203L, PRO291C, PRO291L, PRO297L, PRO29C, PRO29L, PRO343C, PRO348C, PRO375L, PRO377L, PRO392L, SER132C, SER134C, SER146C, SER168C, SER172C, SER199L, SER200C, SER200L, SER217C, SER231C, SER239L, SER241L, SER278L, SER307C, SER330C, SER332C, SER403C, THR128C, THR137C, THR148C, THR171C, THR196L, THR207C, THR209C, THR226C, THR228C, THR260L, THR283C, THR298L, THR306C, THR32C, THR32L, THR336C, THR336L, THR37L, THR385L, THR398C, THR412C, TRP327C, TYR173C, TYR177L, TYR206C, TYR214C, TYR342C, TYR342L, TYR387L, TYR397C, TYR98L, VAL178L, VAL194L, VAL205C, VAL247C, VAL276L, VAL295L, VAL335C, VAL384L
• C-M: LEU113M, LEU120C
• C-N: ALA126N, ALA147N, ALA149N, ALA358N, ALA366C, ALA89C, ARG109C, ARG16C, ARG356N, ARG389C, ARG39C, ARG405N, ARG407N, ARG417C, ARG417N, ARG423C, ASN121N, ASN125N, ASN142N, ASN150N, ASN152N, ASN157N, ASN370C, ASN46C, ASN91C, ASP421N, GLN84C, GLN90C, GLU162C, GLU162N, GLU355N, GLU404N, GLU406N, GLU418N, GLU41C, GLU424C, GLU428C, GLY116N, GLY122N, GLY143N, GLY156N, GLY161C, GLY161N, GLY24C, GLY360C, GLY367C, GLY409N, ILE11C, ILE124N, ILE151N, ILE155N, ILE410N, LEU113C, LEU113N, LEU144N, LEU159N, LEU383C, LEU38C, LEU408N, LEU47C, LYS154N, LYS411N, MET145N, MET427C, PHE422N, PHE426C, PRO114C, PRO13C, PRO21C, PRO25C, PRO415N, SER110C, SER111C, SER146N, SER361C, SER369C, SER40C, SER43C, THR107C, THR112C, THR123N, THR148N, THR22C, THR23C, THR364C, THR420C, THR42C, THR44C, THR48C, THR88C, TYR141N, TYR354N, TYR425N, TYR45C, TYR96C, VAL158N, VAL160N, VAL357N, VAL362C, VAL363C, VAL365C, VAL368C, VAL49C
• C-O: ALA380C, ALA380O, ALA94C, ALA94O, ARG39C, ARG39O, ASN376C, ASN376O, ASN382C, ASN382O, ASN91C, ASN91O, GLN90C, GLN90O, GLU378C, GLU378O, GLU386O, GLU41C, GLU41O, LEU373C, LEU373O, LEU379C, LEU379O, LEU383C, LEU383O, LEU38C, LEU38O, LEU92C, LEU92O, LYS381C, LYS381O, PRO25C, PRO25O, PRO375C, PRO375O, SER40C, SER40O, SER95C, SER95O, THR37C, THR37O, THR385C, THR385O, TYR96C, TYR96O, VAL384C, VAL384O
• C-R: ARG16R, ARG407C, ARG423R, ASN142C, ASN157C, ASP421C, GLU424R, THR44R, VAL365R
• D-E: ALA380D, ALA380E, ALA89D, ALA94D, ALA94E, ARG389D, ARG389E, ARG39D, ARG39E, ASN376D, ASN376E, ASN382D, ASN382E, ASN91D, ASN91E, GLN90D, GLN90E, GLU378D, GLU378E, GLU386D, GLU41D, GLU41E, LEU373D, LEU373E, LEU379D, LEU379E, LEU383D, LEU383E, LEU38D, LEU38E, LEU92D, LEU92E, LYS381D, LYS381E, PRO25D, PRO25E, PRO375D, PRO375E, SER40D, SER40E, SER95D, SER95E, THR37D, THR37E, THR385D, THR385E, TYR96D, TYR96E, VAL384D, VAL384E
• D-L: ALA119L, ALA126L, ALA147L, ALA149L, ALA358D, ALA366D, ALA89D, ARG109D, ARG16D, ARG356L, ARG389D, ARG39D, ARG407L, ARG417D, ARG417L, ARG423D, ASN121D, ASN121L, ASN125L, ASN142L, ASN150L, ASN152L, ASN157L, ASN370D, ASN46D, ASN91D, ASP391D, ASP421L, GLN90D, GLU162L, GLU355L, GLU404L, GLU406L, GLU418L, GLU41D, GLU424D, GLU424L, GLU428D, GLU428L, GLY122L, GLY143L, GLY156L, GLY161D, GLY161L, GLY24D, GLY360D, GLY367D, GLY409L, ILE11D, ILE124L, ILE151L, ILE155L, LEU113D, LEU113L, LEU120L, LEU144L, LEU159L, LEU383D, LEU38D, LEU408L, LEU47D, LYS154L, LYS411L, MET145L, MET20D, MET427D, PHE14D, PHE422L, PHE426D, PRO13D, PRO21D, PRO25D, PRO415L, SER110D, SER111D, SER146L, SER361D, SER369D, SER40D, SER43D, THR107D, THR112D, THR123L, THR148L, THR22D, THR23D, THR364D, THR420D, THR42D, THR44D, THR48D, THR88D, TRP414L, TYR118L, TYR141L, TYR354L, TYR425L, TYR45D, TYR96D, VAL127L, VAL12D, VAL158L, VAL160D, VAL160L, VAL357L, VAL362D, VAL363D, VAL365D, VAL368D, VAL429D, VAL49D
• E-L: ALA147L, ALA149L, ALA186E, ALA195E, ALA210L, ALA211L, ALA232L, ALA259E, ALA275E, ALA277E, ALA329L, ALA334L, ALA380E, ALA394E, ARG100E, ARG179E, ARG202E, ARG202L, ARG204L, ARG274E, ARG347L, ARG389E, ARG405L, ARG407L, ASN150L, ASN152L, ASN233L, ASN280E, ASN288L, ASN293E, ASN293L, ASN299E, ASN341L, ASN376E, ASN382E, ASN396E, ASN396L, ASN97E, ASP138L, ASP153L, ASP174E, ASP174L, ASP182E, ASP190E, ASP198E, ASP201E, ASP201L, ASP212L, ASP213L, ASP235L, ASP258E, ASP279E, ASP287L, ASP30E, ASP30L, ASP31E, ASP31L, ASP391E, CYS197E, CYS99E, GLN130L, GLN215L, GLU135L, GLU245L, GLU300E, GLU311L, GLU34E, GLU378E, GLU386E, GLU404L, GLU406L, GLY131L, GLY143L, GLY176E, GLY181E, GLY188E, GLY243L, GLY244L, GLY285L, GLY331L, GLY339E, GLY339L, GLY340L, GLY344L, GLY388E, GLY393E, GLY393L, HIS249L, HIS338E, HIS36E, ILE151L, ILE184E, ILE187E, ILE208L, ILE227L, ILE234L, ILE242E, ILE242L, ILE286L, ILE28E, ILE28L, ILE296E, ILE308L, ILE312L, ILE337L, ILE374E, ILE401L, ILE410L, LEU136L, LEU144L, LEU167L, LEU169L, LEU175E, LEU175L, LEU180E, LEU189E, LEU18L, LEU229L, LEU240E, LEU246L, LEU289L, LEU294E, LEU310L, LEU333L, LEU33E, LEU346L, LEU373E, LEU379E, LEU383E, LEU400L, LEU402L, LYS154L, LYS192E, LYS309L, LYS35E, LYS381E, LYS399E, LYS399L, LYS411L, MET145L, MET193E, MET290E, MET290L, MET395E, MET395L, PHE129L, PHE14L, PHE216L, PHE230L, PHE292E, PHE292L, PHE390E, PRO170L, PRO183E, PRO185E, PRO191E, PRO203E, PRO203L, PRO291E, PRO291L, PRO297E, PRO29E, PRO29L, PRO343L, PRO348L, PRO375E, PRO377E, PRO392E, SER132L, SER134L, SER146L, SER168L, SER172L, SER199E, SER200E, SER200L, SER217L, SER231L, SER239E, SER241E, SER278E, SER307L, SER330L, SER332L, SER403L, THR128L, THR137L, THR148L, THR171L, THR196E, THR207L, THR209L, THR226L, THR228L, THR260E, THR283L, THR298E, THR306L, THR32E, THR32L, THR336E, THR336L, THR37E, THR385E, THR398L, THR412L, TRP327L, TYR173L, TYR177E, TYR206L, TYR214L, TYR342E, TYR342L, TYR387E, TYR397L, TYR98E, VAL178E, VAL194E, VAL205L, VAL247L, VAL276E, VAL295E, VAL335L, VAL384E
• E-O: ALA126E, ALA147E, ALA149E, ALA358E, ALA366O, ALA89O, ARG109O, ARG16O, ARG356E, ARG389O, ARG39O, ARG405E, ARG407E, ARG417E, ARG417O, ARG423O, ASN121E, ASN121O, ASN125E, ASN142E, ASN150E, ASN152E, ASN157E, ASN370O, ASN46O, ASN91O, ASP421E, GLN84O, GLN90O, GLU162E, GLU162O, GLU355E, GLU404E, GLU406E, GLU418E, GLU41O, GLU424E, GLU424O, GLU428E, GLU428O, GLY122E, GLY143E, GLY156E, GLY161E, GLY161O, GLY24O, GLY360O, GLY367O, GLY409E, ILE124E, ILE151E, ILE155E, ILE410E, LEU113E, LEU113O, LEU120E, LEU144E, LEU159E, LEU383O, LEU38O, LEU408E, LEU47O, LYS154E, LYS411E, MET145E, MET427O, PHE422E, PHE426O, PRO114O, PRO13O, PRO21O, PRO25O, PRO415E, SER110O, SER111O, SER146E, SER361O, SER369O, SER40O, SER43O, THR107O, THR112O, THR123E, THR148E, THR22O, THR23O, THR364O, THR416O, THR420O, THR42O, THR44O, THR48O, THR88O, TYR141E, TYR354E, TYR425E, TYR45O, TYR96O, VAL12O, VAL158E, VAL160E, VAL160O, VAL357E, VAL362O, VAL363O, VAL365O, VAL368O, VAL429O, VAL49O
• F-S: ARG16F, ARG407S, ARG423F, ASN142S, ASN157S, ASN46F, ASP421S, GLU424F, ILE11F, THR123S, THR44F, VAL365F
• F-T: ARG39F, ARG39T, ASN382F, ASN382T, SER95T, TYR96T
• G-K: ALA147K, ALA149K, ALA186G, ALA195G, ALA210K, ALA211K, ALA232K, ALA256G, ALA259G, ALA275G, ALA277G, ALA329K, ALA334K, ALA380G, ARG100G, ARG179G, ARG202G, ARG202K, ARG204K, ARG274G, ARG347K, ARG389G, ARG405K, ARG407K, ASN150K, ASN152K, ASN233K, ASN280G, ASN288K, ASN293G, ASN293K, ASN299G, ASN341K, ASN376G, ASN382G, ASN396G, ASN396K, ASN97G, ASP138K, ASP153K, ASP174G, ASP174K, ASP182G, ASP190G, ASP198G, ASP201G, ASP201K, ASP212K, ASP213K, ASP235K, ASP258G, ASP279G, ASP287K, ASP30G, ASP30K, ASP31G, ASP31K, ASP391G, CYS197G, CYS99G, GLN130K, GLN215K, GLU135K, GLU245K, GLU300G, GLU34G, GLU378G, GLU386G, GLU404K, GLU406K, GLY131K, GLY143K, GLY176G, GLY181G, GLY188G, GLY243G, GLY243K, GLY244K, GLY281G, GLY285K, GLY331K, GLY339G, GLY339K, GLY340K, GLY344K, GLY388G, GLY393G, GLY393K, HIS249K, HIS338G, HIS36G, ILE151K, ILE184G, ILE187G, ILE208K, ILE227K, ILE234K, ILE242G, ILE242K, ILE286K, ILE28G, ILE28K, ILE296G, ILE308K, ILE312K, ILE337K, ILE374G, ILE401K, ILE410K, LEU136K, LEU144K, LEU167K, LEU169K, LEU175G, LEU175K, LEU180G, LEU189G, LEU18K, LEU229K, LEU240G, LEU246K, LEU257G, LEU289K, LEU294G, LEU310K, LEU333K, LEU33G, LEU346K, LEU373G, LEU379G, LEU383G, LEU400K, LEU402K, LYS154K, LYS192G, LYS309K, LYS35G, LYS381G, LYS399G, LYS399K, LYS411K, MET145K, MET193G, MET290G, MET290K, MET395G, MET395K, PHE129K, PHE14K, PHE216K, PHE230K, PHE292G, PHE292K, PHE390G, PRO170K, PRO183G, PRO185G, PRO191G, PRO203G, PRO203K, PRO291G, PRO291K, PRO297G, PRO29G, PRO29K, PRO343K, PRO348K, PRO375G, PRO377G, PRO392G, PRO61K, SER132K, SER134K, SER146K, SER168K, SER172K, SER199G, SER200G, SER200K, SER217K, SER231K, SER239G, SER241G, SER278G, SER307K, SER330K, SER332K, SER403K, THR128K, THR137K, THR148K, THR171K, THR196G, THR207K, THR209K, THR226K, THR228K, THR260G, THR283K, THR298G, THR306K, THR32G, THR32K, THR336G, THR336K, THR37G, THR385G, THR398K, THR412K, TRP327K, TYR173K, TYR177G, TYR206K, TYR214K, TYR342G, TYR342K, TYR387G, TYR397K, TYR98G, VAL178G, VAL194G, VAL205K, VAL247K, VAL276G, VAL295G, VAL335K, VAL384G, VAL413K
• G-M: ALA147G, ALA149G, ALA186M, ALA195M, ALA210G, ALA211G, ALA232G, ALA259M, ALA275M, ALA277M, ALA329G, ALA334G, ALA380M, ARG100M, ARG179M, ARG202G, ARG202M, ARG204G, ARG274M, ARG347G, ARG389M, ARG405G, ASN150G, ASN152G, ASN233G, ASN280M, ASN288G, ASN293G, ASN293M, ASN299M, ASN341G, ASN376M, ASN382M, ASN396G, ASN396M, ASN97M, ASP138G, ASP153G, ASP174G, ASP174M, ASP182M, ASP190M, ASP198M, ASP201G, ASP201M, ASP212G, ASP213G, ASP235G, ASP258M, ASP279M, ASP287G, ASP30G, ASP30M, ASP31G, ASP31M, ASP391M, CYS197M, CYS99M, GLN130G, GLN215G, GLU135G, GLU245G, GLU300M, GLU34M, GLU378M, GLU386M, GLU404G, GLU406G, GLY131G, GLY143G, GLY176M, GLY181M, GLY188M, GLY243G, GLY243M, GLY244G, GLY244M, GLY285G, GLY331G, GLY339M, GLY340G, GLY344G, GLY388M, GLY393G, GLY393M, HIS249G, HIS338M, HIS36M, ILE151G, ILE184M, ILE187M, ILE208G, ILE227G, ILE234G, ILE242G, ILE242M, ILE286G, ILE28G, ILE28M, ILE296M, ILE308G, ILE312G, ILE337G, ILE374M, ILE401G, ILE410G, LEU136G, LEU144G, LEU167G, LEU169G, LEU175G, LEU175M, LEU180M, LEU189M, LEU18G, LEU229G, LEU240M, LEU246G, LEU289G, LEU294M, LEU310G, LEU333G, LEU33M, LEU346G, LEU373M, LEU379M, LEU383M, LEU400G, LEU402G, LYS154G, LYS192M, LYS309G, LYS35M, LYS381M, LYS399G, LYS399M, LYS411G, MET145G, MET193M, MET290G, MET290M, MET395G, MET395M, PHE129G, PHE14G, PHE216G, PHE230G, PHE292G, PHE292M, PHE390M, PRO170G, PRO183M, PRO185M, PRO191M, PRO203G, PRO203M, PRO291G, PRO291M, PRO297M, PRO29G, PRO29M, PRO343G, PRO348G, PRO375M, PRO377M, PRO392M, PRO61G, SER132G, SER134G, SER146G, SER168G, SER172G, SER199M, SER200G, SER200M, SER217G, SER231G, SER239M, SER241M, SER278M, SER307G, SER330G, SER332G, SER403G, THR128G, THR137G, THR148G, THR171G, THR196M, THR207G, THR209G, THR226G, THR228G, THR260M, THR283G, THR298M, THR306G, THR32G, THR32M, THR336G, THR336M, THR350G, THR37M, THR385M, THR398G, THR412G, TRP327G, TYR173G, TYR177M, TYR206G, TYR214G, TYR342G, TYR342M, TYR387M, TYR397G, TYR98M, VAL178M, VAL194M, VAL205G, VAL247G, VAL276M, VAL295M, VAL335G, VAL349G, VAL384M, VAL413G
• G-S: ARG109S, ARG16S, ARG407G, ARG423S, ASN142G, ASN157G, ASP421G, GLU162G, GLU418G, GLU424S, MET427S, THR44S, TYR425G, VAL365S
• H-I: ALA126H, ALA147H, ALA149H, ALA358H, ALA366I, ALA89I, ARG109I, ARG16I, ARG356H, ARG389I, ARG39I, ARG405H, ARG407H, ARG417H, ARG417I, ARG423I, ASN121H, ASN121I, ASN125H, ASN142H, ASN150H, ASN152H, ASN157H, ASN370I, ASN46I, ASN91I, ASP391I, ASP421H, GLN84I, GLN90I, GLU162H, GLU162I, GLU355H, GLU404H, GLU406H, GLU418H, GLU41I, GLU424H, GLU424I, GLU428H, GLU428I, GLY122H, GLY143H, GLY156H, GLY161H, GLY161I, GLY24I, GLY360I, GLY367I, GLY409H, ILE11I, ILE124H, ILE151H, ILE155H, ILE410H, LEU113H, LEU113I, LEU120H, LEU120I, LEU144H, LEU159H, LEU383I, LEU38I, LEU408H, LEU47I, LYS154H, LYS411H, MET145H, MET427I, PHE422H, PRO114I, PRO13I, PRO21I, PRO25I, PRO415H, SER110I, SER111I, SER146H, SER361I, SER369I, SER40I, SER43I, THR107I, THR112I, THR123H, THR148H, THR22I, THR23I, THR364I, THR416I, THR420I, THR42I, THR44I, THR48I, THR88I, TRP414H, TYR141H, TYR354H, TYR425H, TYR45I, TYR96I, VAL127H, VAL12I, VAL158H, VAL160H, VAL160I, VAL357H, VAL362I, VAL363I, VAL365I, VAL368I, VAL49I
• H-N: ALA147H, ALA149H, ALA186N, ALA195N, ALA210H, ALA211H, ALA232H, ALA259N, ALA275N, ALA277N, ALA329H, ALA334H, ALA380N, ARG100N, ARG179N, ARG202H, ARG202N, ARG204H, ARG274N, ARG347H, ARG389N, ARG405H, ASN150H, ASN152H, ASN233H, ASN280N, ASN288H, ASN293H, ASN293N, ASN299N, ASN341H, ASN376N, ASN382N, ASN396H, ASN396N, ASN97N, ASP138H, ASP153H, ASP174H, ASP174N, ASP182N, ASP190N, ASP198N, ASP201H, ASP201N, ASP212H, ASP213H, ASP235H, ASP258N, ASP279N, ASP287H, ASP30H, ASP30N, ASP31H, ASP31N, ASP391N, CYS197N, CYS99N, GLN130H, GLN215H, GLU135H, GLU245H, GLU300N, GLU34N, GLU378N, GLU386N, GLU404H, GLU406H, GLY131H, GLY143H, GLY176N, GLY181N, GLY188N, GLY243H, GLY244H, GLY244N, GLY285H, GLY331H, GLY339N, GLY340H, GLY344H, GLY388N, GLY393H, GLY393N, HIS249H, HIS338N, HIS36N, ILE151H, ILE184N, ILE187N, ILE208H, ILE227H, ILE234H, ILE242H, ILE242N, ILE286H, ILE28H, ILE28N, ILE296N, ILE308H, ILE312H, ILE337H, ILE374N, ILE401H, ILE410H, LEU136H, LEU144H, LEU167H, LEU169H, LEU175H, LEU175N, LEU180N, LEU189N, LEU18H, LEU229H, LEU240N, LEU246H, LEU257N, LEU289H, LEU294N, LEU310H, LEU333H, LEU33N, LEU346H, LEU373N, LEU379N, LEU383N, LEU400H, LEU402H, LYS154H, LYS192N, LYS309H, LYS35N, LYS381N, LYS399H, LYS399N, LYS411H, MET145H, MET193N, MET290H, MET290N, MET395H, MET395N, PHE129H, PHE14H, PHE216H, PHE230H, PHE248H, PHE292H, PHE292N, PHE390N, PRO170H, PRO183N, PRO185N, PRO191N, PRO203H, PRO203N, PRO291H, PRO291N, PRO297N, PRO29H, PRO29N, PRO343H, PRO348H, PRO375N, PRO377N, PRO392N, SER132H, SER134H, SER146H, SER168H, SER172H, SER199N, SER200H, SER200N, SER217H, SER231H, SER239N, SER241N, SER278N, SER307H, SER330H, SER332H, SER403H, THR128H, THR137H, THR148H, THR171H, THR196N, THR207H, THR209H, THR226H, THR228H, THR260N, THR283H, THR298N, THR306H, THR32H, THR32N, THR336H, THR336N, THR37N, THR385N, THR398H, THR412H, TRP327H, TYR173H, TYR177N, TYR206H, TYR214H, TYR342H, TYR342N, TYR387N, TYR397H, TYR98N, VAL178N, VAL194N, VAL205H, VAL247H, VAL276N, VAL295N, VAL335H, VAL384N, VAL413H
• H-O: ALA147O, ALA149O, ALA186H, ALA195H, ALA210O, ALA211O, ALA232O, ALA259H, ALA275H, ALA277H, ALA329O, ALA334O, ALA380H, ARG100H, ARG179H, ARG202H, ARG202O, ARG204O, ARG274H, ARG347O, ARG389H, ARG405O, ARG407O, ASN150O, ASN152O, ASN233O, ASN280H, ASN288O, ASN293H, ASN293O, ASN299H, ASN341O, ASN376H, ASN382H, ASN396H, ASN396O, ASN97H, ASP138O, ASP153O, ASP174H, ASP174O, ASP182H, ASP190H, ASP198H, ASP201H, ASP201O, ASP212O, ASP213O, ASP235O, ASP258H, ASP279H, ASP287O, ASP30H, ASP30O, ASP31H, ASP31O, ASP391H, CYS197H, CYS99H, GLN130O, GLN215O, GLU135O, GLU245O, GLU300H, GLU311O, GLU34H, GLU378H, GLU386H, GLU404O, GLU406O, GLY131O, GLY143O, GLY176H, GLY181H, GLY188H, GLY243H, GLY243O, GLY244H, GLY244O, GLY281H, GLY285O, GLY331O, GLY339H, GLY339O, GLY340O, GLY344O, GLY388H, GLY393H, GLY393O, HIS249O, HIS338H, HIS36H, ILE151O, ILE184H, ILE187H, ILE208O, ILE227O, ILE234O, ILE242H, ILE242O, ILE286O, ILE28H, ILE28O, ILE296H, ILE308O, ILE312O, ILE337O, ILE374H, ILE401O, ILE410O, LEU136O, LEU144O, LEU167O, LEU169O, LEU175H, LEU175O, LEU180H, LEU189H, LEU18O, LEU229O, LEU240H, LEU246O, LEU289O, LEU294H, LEU310O, LEU333O, LEU33H, LEU346O, LEU373H, LEU379H, LEU383H, LEU400O, LEU402O, LYS154O, LYS192H, LYS309O, LYS35H, LYS381H, LYS399H, LYS399O, LYS411O, MET145O, MET193H, MET290H, MET290O, MET395H, MET395O, PHE129O, PHE14O, PHE216O, PHE230O, PHE292H, PHE292O, PHE390H, PRO170O, PRO183H, PRO185H, PRO191H, PRO203H, PRO203O, PRO291H, PRO291O, PRO297H, PRO29H, PRO29O, PRO343O, PRO348O, PRO375H, PRO377H, PRO392H, PRO61O, SER132O, SER134O, SER146O, SER168O, SER172O, SER199H, SER200H, SER200O, SER217O, SER231O, SER239H, SER241H, SER278H, SER307O, SER330O, SER332O, SER403O, THR128O, THR137O, THR148O, THR171O, THR196H, THR207O, THR209O, THR226O, THR228O, THR260H, THR283O, THR298H, THR306O, THR32H, THR32O, THR336H, THR336O, THR37H, THR385H, THR398O, THR412O, TRP327O, TYR173O, TYR177H, TYR206O, TYR214O, TYR342H, TYR342O, TYR387H, TYR397O, TYR98H, VAL178H, VAL194H, VAL205O, VAL247O, VAL276H, VAL295H, VAL335O, VAL384H
• I-J: ALA147I, ALA149I, ALA186J, ALA195J, ALA210I, ALA211I, ALA232I, ALA259J, ALA275J, ALA277J, ALA329I, ALA334I, ALA380J, ARG100J, ARG179J, ARG202I, ARG202J, ARG204I, ARG274J, ARG347I, ARG389J, ARG405I, ASN150I, ASN152I, ASN233I, ASN280J, ASN288I, ASN293I, ASN293J, ASN299J, ASN341I, ASN376J, ASN382J, ASN396I, ASN396J, ASN97J, ASP138I, ASP153I, ASP174I, ASP174J, ASP182J, ASP190J, ASP198J, ASP201I, ASP201J, ASP212I, ASP213I, ASP235I, ASP258J, ASP279J, ASP287I, ASP30I, ASP30J, ASP31I, ASP31J, ASP391J, CYS197J, CYS99J, GLN130I, GLN215I, GLU135I, GLU245I, GLU245J, GLU300J, GLU311I, GLU34J, GLU378J, GLU386J, GLU404I, GLU406I, GLY131I, GLY143I, GLY176J, GLY181J, GLY188J, GLY243I, GLY243J, GLY244I, GLY244J, GLY285I, GLY331I, GLY339I, GLY339J, GLY340I, GLY344I, GLY388J, GLY393I, GLY393J, HIS249I, HIS338J, HIS36J, ILE151I, ILE184J, ILE187J, ILE208I, ILE227I, ILE234I, ILE242I, ILE242J, ILE286I, ILE28I, ILE28J, ILE296J, ILE308I, ILE312I, ILE337I, ILE374J, ILE401I, ILE410I, LEU136I, LEU144I, LEU169I, LEU175I, LEU175J, LEU180J, LEU189J, LEU18I, LEU229I, LEU240J, LEU246I, LEU289I, LEU294J, LEU310I, LEU333I, LEU33J, LEU346I, LEU373J, LEU379J, LEU383J, LEU400I, LEU402I, LYS154I, LYS192J, LYS309I, LYS35J, LYS381J, LYS399I, LYS399J, MET145I, MET193J, MET290I, MET290J, MET395I, MET395J, PHE129I, PHE14I, PHE216I, PHE230I, PHE292I, PHE292J, PHE390J, PRO170I, PRO183J, PRO185J, PRO191J, PRO203I, PRO203J, PRO291I, PRO291J, PRO297J, PRO29I, PRO29J, PRO343I, PRO348I, PRO375J, PRO377J, PRO392J, SER132I, SER134I, SER146I, SER168I, SER172I, SER199J, SER200I, SER200J, SER217I, SER231I, SER239J, SER241J, SER278J, SER307I, SER330I, SER332I, SER403I, THR128I, THR137I, THR148I, THR171I, THR196J, THR207I, THR209I, THR226I, THR228I, THR260J, THR283I, THR298J, THR306I, THR32I, THR32J, THR336I, THR336J, THR37J, THR385J, THR398I, THR412I, TRP327I, TYR173I, TYR177J, TYR206I, TYR214I, TYR342I, TYR342J, TYR387J, TYR397I, TYR98J, VAL178J, VAL194J, VAL205I, VAL247I, VAL276J, VAL295J, VAL335I, VAL349I, VAL384J
• I-N: ALA380I, ALA380N, ALA94I, ALA94N, ARG39I, ARG39N, ASN376I, ASN376N, ASN382I, ASN382N, ASN91I, ASN91N, GLN90I, GLN90N, GLU378I, GLU378N, GLU386I, GLU41I, GLU41N, LEU373I, LEU373N, LEU379I, LEU379N, LEU383I, LEU383N, LEU38I, LEU38N, LEU92I, LEU92N, LYS381I, LYS381N, PRO25I, PRO25N, PRO375I, PRO375N, SER40I, SER40N, SER95I, SER95N, THR37I, THR37N, THR385I, THR385N, TYR96I, TYR96N, VAL384I, VAL384N
• I-Q: ALA149Q, ALA380I, ARG179I, ARG202I, ARG202Q, ARG204Q, ARG274I, ARG347Q, ARG389I, ARG405Q, ASN150Q, ASN233Q, ASN293I, ASN293Q, ASN341Q, ASP138Q, ASP153Q, ASP174I, ASP174Q, ASP182I, ASP190I, ASP198I, ASP201I, ASP201Q, ASP212Q, ASP213Q, ASP258I, ASP287Q, ASP30I, ASP30Q, ASP31I, ASP31Q, GLU135Q, GLU245Q, GLU300I, GLU34I, GLU386I, GLU404Q, GLU406Q, ILE187I, ILE28Q, LEU189I, LEU18Q, LEU229Q, LEU33I, LYS192I, LYS35I, LYS381I, LYS399Q, PHE14Q, PRO185I, PRO29Q, SER172Q, SER231Q, THR137Q, THR196I, THR207Q, THR209Q, THR385I, TYR173Q, TYR387I, VAL194I, VAL205Q
• J-K: ALA126J, ALA147J, ALA149J, ALA358J, ALA366K, ALA430K, ALA89K, ARG109K, ARG16K, ARG356J, ARG389K, ARG39K, ARG407J, ARG417J, ARG423K, ASN121J, ASN121K, ASN125J, ASN142J, ASN150J, ASN152J, ASN157J, ASN370K, ASN46K, ASN91K, ASP391K, ASP421J, GLN84K, GLN90K, GLU162J, GLU162K, GLU355J, GLU406J, GLU418J, GLU41K, GLU424J, GLU424K, GLU428K, GLY115K, GLY122J, GLY143J, GLY156J, GLY161J, GLY161K, GLY24K, GLY360K, GLY367K, GLY409J, ILE124J, ILE151J, ILE155J, ILE410J, LEU113K, LEU120J, LEU120K, LEU144J, LEU159J, LEU383K, LEU38K, LEU408J, LEU47K, LYS154J, LYS411J, MET145J, MET20K, MET427K, PHE14K, PHE422J, PHE426K, PRO114K, PRO13K, PRO21K, PRO25K, PRO415J, SER110K, SER111K, SER146J, SER361K, SER369K, SER40K, SER43K, THR107K, THR112K, THR123J, THR148J, THR22K, THR23K, THR364K, THR416K, THR420K, THR42K, THR44K, THR48K, THR88K, TRP414J, TYR141J, TYR354J, TYR425J, TYR45K, TYR96K, VAL12K, VAL158J, VAL160J, VAL160K, VAL357J, VAL362K, VAL363K, VAL365K, VAL368K, VAL429K, VAL49K
• J-P: ALA119P, ALA126P, ALA147P, ALA149P, ALA366J, ALA89J, ARG109J, ARG16J, ARG356P, ARG389J, ARG39J, ARG405P, ARG407P, ARG417P, ARG423J, ASN121P, ASN125P, ASN142P, ASN150P, ASN152P, ASN157P, ASN370J, ASN46J, ASN91J, ASP421P, GLN84J, GLN90J, GLU162J, GLU162P, GLU355P, GLU404P, GLU406P, GLU418P, GLU41J, GLU424J, GLU424P, GLU428J, GLY122P, GLY143P, GLY156P, GLY161J, GLY161P, GLY24J, GLY360J, GLY367J, GLY409P, ILE124P, ILE151P, ILE155P, ILE410P, LEU120P, LEU144P, LEU159P, LEU38J, LEU408P, LEU47J, LYS154P, LYS411P, MET145P, MET20J, MET427J, PHE422P, PHE426J, PRO13J, PRO21J, PRO25J, PRO415P, SER110J, SER111J, SER146P, SER361J, SER369J, SER40J, SER43J, THR107J, THR112J, THR123P, THR148P, THR22J, THR23J, THR364J, THR420J, THR42J, THR44J, THR48J, THR88J, TRP414P, TYR141P, TYR354P, TYR425J, TYR425P, TYR45J, TYR96J, VAL127P, VAL12J, VAL158P, VAL160J, VAL160P, VAL362J, VAL363J, VAL365J, VAL368J, VAL429J, VAL429P, VAL49J
• J-Q: ALA149J, ALA380Q, ARG179Q, ARG202J, ARG202Q, ARG204J, ARG274Q, ARG347J, ARG389Q, ARG405J, ASN150J, ASN233J, ASN341J, ASP138J, ASP153J, ASP174J, ASP174Q, ASP182Q, ASP190Q, ASP198Q, ASP201J, ASP201Q, ASP212J, ASP213J, ASP258Q, ASP287J, ASP30J, ASP30Q, ASP31J, ASP31Q, GLN130J, GLU135J, GLU245J, GLU300Q, GLU34Q, GLU386Q, GLU404J, GLU406J, ILE187Q, ILE28Q, LEU189Q, LEU229J, LEU33Q, LYS192Q, LYS35Q, LYS381Q, LYS399J, MET395J, PRO185Q, PRO29Q, SER172J, SER200Q, SER231J, SER278Q, THR196Q, THR207J, THR209J, THR385Q, TYR173J, TYR98Q, VAL194Q, VAL205J
• K-M: ALA147M, ALA149M, ALA186K, ALA195K, ALA210M, ALA211M, ALA232M, ALA259K, ALA275K, ALA277K, ALA329M, ALA334M, ALA380K, ALA394K, ARG100K, ARG179K, ARG202K, ARG202M, ARG204M, ARG274K, ARG347M, ARG389K, ARG405M, ASN150M, ASN152M, ASN233M, ASN280K, ASN288M, ASN293K, ASN293M, ASN299K, ASN341M, ASN376K, ASN382K, ASN396K, ASN396M, ASN97K, ASP138M, ASP153M, ASP174K, ASP174M, ASP182K, ASP190K, ASP198K, ASP201K, ASP201M, ASP212M, ASP213M, ASP235M, ASP258K, ASP279K, ASP287M, ASP30K, ASP30M, ASP31K, ASP31M, ASP391K, CYS197K, CYS99K, GLN130M, GLN215M, GLU135M, GLU245M, GLU300K, GLU34K, GLU378K, GLU386K, GLU404M, GLU406M, GLY131M, GLY143M, GLY176K, GLY181K, GLY188K, GLY243M, GLY244K, GLY244M, GLY285M, GLY331M, GLY339K, GLY339M, GLY340M, GLY344M, GLY388K, GLY393K, GLY393M, HIS249M, HIS338K, HIS36K, ILE151M, ILE184K, ILE187K, ILE208M, ILE227M, ILE234M, ILE242K, ILE242M, ILE286M, ILE28K, ILE28M, ILE296K, ILE308M, ILE312M, ILE337M, ILE374K, ILE401M, ILE410M, LEU136M, LEU144M, LEU169M, LEU175K, LEU175M, LEU180K, LEU189K, LEU18M, LEU229M, LEU240K, LEU246M, LEU289M, LEU294K, LEU310M, LEU333M, LEU33K, LEU346M, LEU373K, LEU379K, LEU383K, LEU400M, LEU402M, LYS154M, LYS192K, LYS309M, LYS35K, LYS381K, LYS399K, LYS399M, LYS411M, MET145M, MET193K, MET290K, MET290M, MET395K, MET395M, PHE129M, PHE14M, PHE216M, PHE230M, PHE292K, PHE292M, PHE390K, PRO170M, PRO183K, PRO185K, PRO191K, PRO203K, PRO203M, PRO291K, PRO291M, PRO297K, PRO29K, PRO29M, PRO343M, PRO348M, PRO375K, PRO377K, PRO392K, SER132M, SER134M, SER146M, SER168M, SER172M, SER199K, SER200K, SER200M, SER217M, SER231M, SER239K, SER241K, SER278K, SER307M, SER330M, SER332M, SER403M, THR128M, THR137M, THR148M, THR171M, THR196K, THR207M, THR209M, THR226M, THR228M, THR260K, THR283M, THR284M, THR298K, THR306M, THR32K, THR32M, THR336K, THR336M, THR37K, THR385K, THR398M, THR412M, TRP327M, TYR173M, TYR177K, TYR206M, TYR214M, TYR342K, TYR342M, TYR387K, TYR397M, TYR98K, VAL178K, VAL194K, VAL205M, VAL247M, VAL276K, VAL295K, VAL335M, VAL384K, VAL413M
• K-Q: ARG39K, ARG39Q, ASN382K, ASN382Q, PRO25Q, SER95Q, TYR96Q, VAL384K
• L-R: ARG39L, ARG39R, ASN382L, ASN382R, TYR96L, TYR96R
• L-T: ARG109L, ARG16L, ARG407T, ARG423L, ASN157T, ASN46L, ASP421T, GLU162T, GLU418T, GLU424L, THR123T, TYR45L, VAL365L
• M-Q: ALA149M, ARG16Q, ARG405M, ARG407M, ARG423Q, ASN121M, ASN150M, ASN152M, ASN157M, ASP421M, GLU404M, GLU406M, GLU418M, GLU424Q, GLY24Q, GLY409M, ILE11Q, ILE151M, ILE155M, ILE410M, LEU113Q, LEU408M, LYS411M, PHE14Q, PRO13Q, PRO21Q, PRO25Q, PRO415M, THR22Q, THR23Q, VAL12Q, VAL365Q
• M-R: ARG16M, ARG407R, ARG423M, ASN46M, ASP421R, GLU418R, GLU424M, LEU113M, LEU120R, THR123R
• M-S: ARG39M, ARG39S, ASN382M, ASN382S, SER95S, TYR96M
• N-O: ALA147N, ALA149N, ALA186O, ALA195O, ALA210N, ALA211N, ALA232N, ALA259O, ALA275O, ALA277O, ALA329N, ALA334N, ALA380O, ALA394O, ARG100O, ARG179O, ARG202N, ARG202O, ARG204N, ARG274O, ARG347N, ARG389O, ARG405N, ASN150N, ASN152N, ASN233N, ASN280O, ASN288N, ASN293N, ASN293O, ASN299O, ASN341N, ASN376O, ASN382O, ASN396N, ASN396O, ASN97O, ASP138N, ASP153N, ASP174N, ASP174O, ASP182O, ASP190O, ASP198O, ASP201N, ASP201O, ASP212N, ASP213N, ASP235N, ASP258O, ASP279O, ASP287N, ASP30N, ASP30O, ASP31N, ASP31O, ASP391O, CYS197O, CYS99O, GLN130N, GLN215N, GLU135N, GLU245N, GLU300O, GLU311N, GLU34O, GLU378O, GLU386O, GLU404N, GLU406N, GLY131N, GLY143N, GLY176O, GLY181O, GLY188O, GLY243N, GLY244N, GLY244O, GLY285N, GLY331N, GLY339N, GLY339O, GLY340N, GLY344N, GLY388O, GLY393N, GLY393O, HIS249N, HIS338O, HIS36O, ILE151N, ILE184O, ILE187O, ILE208N, ILE227N, ILE234N, ILE242N, ILE242O, ILE286N, ILE28N, ILE28O, ILE296O, ILE308N, ILE312N, ILE337N, ILE374O, ILE401N, ILE410N, LEU136N, LEU144N, LEU167N, LEU169N, LEU175N, LEU175O, LEU180O, LEU189O, LEU18N, LEU229N, LEU240O, LEU246N, LEU289N, LEU294O, LEU310N, LEU333N, LEU33O, LEU346N, LEU373O, LEU379O, LEU383O, LEU400N, LEU402N, LYS154N, LYS192O, LYS309N, LYS35O, LYS381O, LYS399N, LYS399O, LYS411N, MET145N, MET193O, MET290N, MET290O, MET395N, MET395O, PHE129N, PHE14N, PHE216N, PHE230N, PHE292N, PHE292O, PHE390O, PRO170N, PRO183O, PRO185O, PRO191O, PRO203N, PRO203O, PRO291N, PRO291O, PRO297O, PRO29N, PRO29O, PRO343N, PRO348N, PRO375O, PRO377O, PRO392O, PRO61N, SER132N, SER134N, SER146N, SER168N, SER172N, SER199O, SER200N, SER200O, SER217N, SER231N, SER239O, SER241O, SER278O, SER307N, SER330N, SER332N, SER403N, THR128N, THR137N, THR148N, THR171N, THR196O, THR207N, THR209N, THR226N, THR228N, THR238O, THR260O, THR283N, THR298O, THR306N, THR32N, THR32O, THR336N, THR336O, THR350N, THR37O, THR385O, THR398N, THR412N, TRP327N, TYR173N, TYR177O, TYR206N, TYR214N, TYR342N, TYR342O, TYR387O, TYR397N, TYR98O, VAL178O, VAL194O, VAL205N, VAL247N, VAL276O, VAL295O, VAL335N, VAL384O
• N-Q: ARG109N, ARG16N, ARG407Q, ARG423N, ASN157Q, ASN46N, ASP421Q, GLU162Q, GLU418Q, GLU424N, THR123Q, VAL365N
• R-S: ALA149R, ALA380S, ARG179S, ARG202R, ARG202S, ARG204R, ARG274S, ARG347R, ARG389S, ARG405R, ASN150R, ASN233R, ASN341R, ASP138R, ASP153R, ASP174R, ASP174S, ASP182S, ASP190S, ASP198S, ASP201R, ASP201S, ASP212R, ASP213R, ASP258S, ASP287R, ASP30R, ASP30S, ASP31R, ASP31S, GLN130R, GLU135R, GLU245R, GLU300S, GLU34S, GLU386S, GLU404R, GLU406R, ILE187S, LEU189S, LEU229R, LEU33S, LYS192S, LYS35S, LYS381S, LYS399R, PRO185S, SER172R, SER200S, SER231R, THR196S, THR207R, THR209R, THR385S, TYR173R, TYR98S, VAL194S, VAL205R
• R-T: ALA149T, ALA380R, ARG179R, ARG202R, ARG202T, ARG204T, ARG274R, ARG347T, ARG389R, ARG405T, ASN150T, ASN233T, ASN293R, ASP138T, ASP153T, ASP174R, ASP174T, ASP182R, ASP190R, ASP198R, ASP201R, ASP201T, ASP212T, ASP213T, ASP258R, ASP287T, ASP30R, ASP30T, ASP31R, ASP31T, GLU135T, GLU245T, GLU300R, GLU34R, GLU386R, GLU404T, GLU406T, GLY244T, ILE187R, LEU189R, LEU229T, LEU33R, LYS192R, LYS35R, LYS381R, LYS399T, PRO185R, SER172T, SER231T, THR137T, THR196R, THR207T, THR209T, THR385R, TYR173T, VAL194R, VAL205T
• S-T: ALA149S, ALA380T, ARG179T, ARG202S, ARG202T, ARG204S, ARG274T, ARG347S, ARG389T, ARG405S, ASN150S, ASN233S, ASN341S, ASP138S, ASP153S, ASP174S, ASP174T, ASP182T, ASP190T, ASP198T, ASP201S, ASP201T, ASP212S, ASP213S, ASP258T, ASP287S, ASP30S, ASP30T, ASP31S, ASP31T, ASP391T, GLN130S, GLU135S, GLU245S, GLU300T, GLU34T, GLU386T, GLU404S, GLU406S, ILE187T, LEU189T, LEU229S, LEU33T, LYS192T, LYS35T, LYS381T, LYS399S, PRO185T, SER172S, SER200T, SER231S, THR196T, THR207S, THR209S, THR385T, TYR173S, TYR98T, VAL194T, VAL205S