2CF7

asp74ala mutant crystal structure for dps-like peroxide resistance protein dpr from streptococcus suis.

• Total interactions analyzed: 66
• Total true interactions: 30
• Strongest Interaction:
  • Chains: C-E
  • Int. Res.: 47
  • Norm. En. per Res.: -5.0278
• Hub Node: A(5)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-C	-42.7133	9.2413	-323.777	-357.249	117	6	5	12320	0	32	36
A-E	-20.8969	-31.6772	-111.681	-164.2551	50	2	2	4624	3	12	18
A-H	-49.3191	-28.5166	-151.179	-229.0146	49	5	3	5333	2	11	8
A-I	-19.0317	-32.2204	-113.253	-164.5051	53	1	2	4691	3	12	18
A-K	-46.2559	-11.039	-143.001	-200.2959	48	6	2	5137	1	12	8
B-D	-39.0357	10.3136	-314.028	-342.75	116	9	5	11997	0	32	35
B-F	-50.3457	-29.205	-151.705	-231.2558	50	4	3	5376	2	12	7
B-G	-17.1393	-44.8196	-112.882	-174.8409	49	1	2	4722	3	13	18
B-J	-45.4046	-39.315	-157.962	-242.6816	49	6	2	5398	3	12	8
B-L	-18.9692	-31.9932	-115.565	-166.5273	51	2	2	4703	3	12	18
C-E	-48.3877	-33.6843	-154.236	-236.308	47	4	2	5319	2	12	8
C-H	-18.1443	-29.9684	-112.726	-160.8387	49	1	2	4717	3	11	18
C-J	-32.8735	-30.7152	-112.568	-176.1567	50	2	2	4685	3	12	18
C-L	-45.8338	-28.0261	-144.29	-218.1499	51	4	2	5089	2	12	8
D-F	-20.5361	-22.9022	-113.222	-156.6603	53	3	2	4782	3	11	21
D-G	-49.8422	-37.9586	-151.76	-239.5608	50	5	3	5171	3	12	8
D-I	-44.7419	-32.8069	-152.424	-229.9728	49	6	2	5297	2	12	8
D-K	-18.2242	-35.6149	-114.022	-167.8611	49	1	2	4690	3	12	18
E-G	-31.1511	14.6651	-317.723	-334.209	112	7	5	11954	0	32	35
E-I	-26.8322	-31.716	-112.373	-170.9212	49	2	2	4660	3	13	19
E-L	-48.1525	-33.8929	-144.901	-226.9464	50	11	3	5418	2	12	8
F-H	-36.1436	27.9486	-316.057	-324.252	114	8	5	11882	0	32	35
F-J	-45.2959	-33.0732	-155.588	-233.9571	50	7	2	5479	2	12	8
F-K	-18.0957	-36.5001	-114.527	-169.1228	52	1	2	4714	3	12	20
G-I	-47.0123	-30.2193	-151.368	-228.5996	49	5	3	5314	2	12	8
G-L	-18.9876	-43.5325	-111.035	-173.5551	50	2	2	4750	3	12	18
H-J	-19.3477	-35.4274	-112.432	-167.2071	49	1	2	4641	3	12	18
H-K	-44.4979	-33.7121	-157.809	-236.019	50	7	2	5532	2	12	8
I-K	-32.7338	23.6777	-317.488	-326.5442	112	6	5	11964	0	32	35
J-L	-35.5836	6.9272	-310.399	-339.0554	117	13	5	11896	0	32	35

Interface residues

• A-C: ALA14A, ALA34A, ALA34C, ALA39A, ALA39C, ALA74A, ALA74C, ALA86A, ALA86C, ARG117A, ARG117C, ARG51A, ARG51C, ASN30A, ASN30C, ASN97A, ASN97C, ASP106A, ASP106C, ASP35A, ASP35C, ASP63A, ASP63C, ASP70A, ASP70C, GLN45A, GLN45C, GLU102A, GLU102C, GLU67A, GLU67C, GLU78A, GLU78C, GLU93A, GLU93C, GLU96A, GLU96C, GLY105A, GLY105C, GLY84A, GLY84C, GLY85A, GLY85C, HIS40A, HIS40C, HIS44A, HIS44C, HIS47A, HIS47C, HIS59A, HIS59C, ILE42A, ILE42C, ILE81A, ILE81C, LEU104A, LEU104C, LEU36A, LEU36C, LEU43A, LEU43C, LEU73A, LEU73C, LEU80A, LEU80C, LEU91A, LEU91C, LYS101A, LYS101C, LYS92A, LYS92C, MET50A, MET50C, MET76A, MET76C, PHE16A, PHE55A, PHE55C, PHE88A, PHE88C, PHE94A, PHE94C, PRO18A, PRO87A, PRO87C, SER15A, SER17A, SER37A, SER37C, SER41A, SER41C, SER77A, SER77C, SER89A, SER89C, SER95A, SER95C, SER98A, SER98C, THR82A, THR82C, THR90A, THR90C, TRP48A, TRP48C, TYR107A, TYR107C, TYR49A, TYR49C, VAL103A, VAL103C, VAL33A, VAL33C, VAL38A, VAL38C, VAL46A, VAL46C
• A-E: ALA126E, ALA151E, ALA153E, ALA164E, ALA169E, ALA74A, ARG79A, ASN145A, ASN145E, ASN149E, ASP134E, ASP137A, ASP137E, ASP141A, ASP146A, ASP146E, GLN130E, GLN163E, GLU156E, GLU75A, GLU78A, GLY140A, GLY84A, GLY85A, HIS158E, ILE147A, ILE155E, ILE159E, ILE81A, LEU172E, LEU80A, LEU83A, LYS152E, LYS157E, LYS171E, MET161E, MET76A, PHE129E, PHE133E, PHE148E, PRO170E, SER142A, SER154E, SER77A, THR144A, THR82A, TRP160E, VAL143A, VAL150A, VAL150E
• A-H: ALA164H, ALA169H, ARG51A, ARG53A, ARG53H, ASN108A, GLN163H, GLN168H, GLU112H, GLU113H, GLU165A, GLU165H, GLU64H, GLY167H, GLY52A, GLY52H, GLY54A, GLY54H, HIS158H, HIS47A, HIS59A, ILE111A, ILE111H, ILE57A, ILE57H, LEU115H, LEU162H, LEU166H, LYS157H, LYS171H, LYS61H, MET161H, MET50A, MET56A, MET62H, PHE55A, PHE55H, PRO170H, PRO60A, THR110A, THR110H, TRP160H, TRP48A, TRP58A, TRP58H, TYR107A, TYR49A, TYR65H, VAL109A
• A-I: ALA126A, ALA151A, ALA153A, ALA164A, ALA169A, ALA74I, ARG123A, ARG79I, ASN145A, ASN145I, ASN149A, ASP134A, ASP137A, ASP137I, ASP141I, ASP146A, ASP146I, GLN130A, GLN163A, GLU156A, GLU75I, GLU78I, GLY140I, GLY84I, GLY85I, HIS158A, ILE147I, ILE155A, ILE159A, ILE81I, LEU172A, LEU22I, LEU80I, LEU83I, LYS152A, LYS157A, LYS171A, LYS26I, MET161A, MET76I, PHE129A, PHE133A, PHE148A, PRO170A, SER142I, SER154A, SER77I, THR144I, THR82I, TRP160A, VAL143I, VAL150A, VAL150I
• A-K: ALA164A, ALA169A, ARG51K, ARG53A, ARG53K, ASN108K, GLN163A, GLN168A, GLU112A, GLU113A, GLU165A, GLU165K, GLU64A, GLY167A, GLY52A, GLY52K, GLY54A, GLY54K, HIS158A, HIS47K, HIS59K, ILE111A, ILE111K, ILE57A, ILE57K, LEU115A, LEU162A, LEU166A, LYS157A, LYS171A, LYS61A, MET161A, MET50K, MET56A, MET56K, MET62A, PHE55A, PHE55K, PRO170A, PRO60K, THR110A, TRP160A, TRP48K, TRP58A, TRP58K, TYR107K, TYR49K, TYR65A
• B-D: ALA34B, ALA34D, ALA39B, ALA39D, ALA74B, ALA74D, ALA86B, ALA86D, ARG117B, ARG117D, ARG51B, ARG51D, ASN30B, ASN30D, ASN97B, ASN97D, ASP106B, ASP106D, ASP35D, ASP63B, ASP63D, ASP70B, ASP70D, GLN45B, GLN45D, GLU102B, GLU102D, GLU67B, GLU67D, GLU75B, GLU75D, GLU78B, GLU78D, GLU93B, GLU93D, GLU96B, GLU96D, GLY105B, GLY105D, GLY84B, GLY84D, GLY85B, GLY85D, HIS40B, HIS40D, HIS44B, HIS44D, HIS47B, HIS47D, HIS59B, HIS59D, ILE42B, ILE42D, ILE81B, ILE81D, LEU104B, LEU104D, LEU36B, LEU36D, LEU43B, LEU43D, LEU73B, LEU73D, LEU80B, LEU80D, LEU83B, LEU83D, LEU91B, LEU91D, LYS101B, LYS101D, LYS92B, LYS92D, MET50B, MET50D, MET66B, MET76B, MET76D, PHE55B, PHE55D, PHE88B, PHE88D, PHE94B, PHE94D, PRO87B, PRO87D, SER37B, SER37D, SER41B, SER41D, SER77B, SER77D, SER89B, SER89D, SER95B, SER95D, SER98B, SER98D, THR82B, THR82D, THR90B, THR90D, TRP48B, TRP48D, TYR107B, TYR107D, TYR49B, TYR49D, VAL103B, VAL103D, VAL33B, VAL33D, VAL38B, VAL38D, VAL46B, VAL46D
• B-F: ALA164F, ALA169F, ARG51B, ARG53B, ARG53F, ASN108B, GLN163F, GLN168F, GLU112F, GLU113F, GLU165B, GLU165F, GLU64F, GLY167F, GLY52B, GLY52F, GLY54B, GLY54F, HIS158F, HIS47B, HIS59B, ILE111B, ILE111F, ILE57B, ILE57F, LEU115F, LEU162F, LEU166F, LYS157F, LYS171F, LYS61F, MET161F, MET50B, MET56B, MET56F, MET62F, PHE55B, PHE55F, PRO170F, PRO60B, THR110B, THR110F, TRP160F, TRP48B, TRP58B, TRP58F, TYR107B, TYR49B, TYR65F, VAL109B
• B-G: ALA126G, ALA151G, ALA153G, ALA164G, ALA169G, ALA74B, ARG79B, ASN145B, ASN145G, ASN149G, ASP134G, ASP137B, ASP137G, ASP141B, ASP146B, ASP146G, GLN130G, GLN163G, GLU156G, GLU75B, GLU78B, GLY140B, GLY84B, GLY85B, HIS158G, ILE147B, ILE155G, ILE159G, ILE81B, LEU172G, LEU80B, LEU83B, LYS152G, LYS157G, LYS171G, MET161G, MET76B, PHE133G, PHE148G, PRO170G, SER142B, SER154G, SER77B, THR144B, THR82B, TRP160G, VAL143B, VAL150B, VAL150G
• B-J: ALA164B, ALA169B, ARG51J, ARG53B, ARG53J, ASN108J, GLN163B, GLN168B, GLU112B, GLU113B, GLU165B, GLU165J, GLU64B, GLY167B, GLY52B, GLY52J, GLY54B, GLY54J, HIS158B, HIS47J, HIS59J, ILE111B, ILE111J, ILE57B, ILE57J, LEU115B, LEU162B, LEU166B, LYS157B, LYS171B, LYS61B, MET161B, MET50J, MET56B, MET56J, MET62B, PHE55B, PHE55J, PRO170B, PRO60B, PRO60J, THR110B, TRP160B, TRP48J, TRP58B, TRP58J, TYR107J, TYR49J, TYR65B
• B-L: ALA126B, ALA151B, ALA153B, ALA164B, ALA169B, ALA74L, ARG123B, ARG79L, ASN145B, ASN145L, ASN149B, ASP134B, ASP137B, ASP137L, ASP141L, ASP146B, ASP146L, GLN130B, GLN163B, GLU156B, GLU75L, GLU78L, GLY140L, GLY84L, GLY85L, HIS158B, ILE147L, ILE155B, ILE159B, ILE81L, LEU172B, LEU22L, LEU80L, LEU83L, LYS152B, LYS157B, LYS171B, MET161B, MET76L, PHE133B, PHE148B, PRO170B, SER142L, SER154B, SER77L, THR144L, THR82L, TRP160B, VAL143L, VAL150B, VAL150L
• C-E: ALA164E, ALA169E, ARG51C, ARG53C, ARG53E, ASN108C, GLN163E, GLN168E, GLU112E, GLU113E, GLU165C, GLU165E, GLU64E, GLY167E, GLY52C, GLY52E, GLY54C, GLY54E, HIS158E, HIS47C, HIS59C, ILE111E, ILE57C, ILE57E, LEU115E, LEU162E, LEU166E, LYS157E, LYS171E, LYS61E, MET161E, MET50C, MET56C, MET62E, PHE55C, PHE55E, PRO170E, PRO60C, THR110C, THR110E, TRP160E, TRP48C, TRP58C, TRP58E, TYR107C, TYR49C, TYR65E
• C-H: ALA126H, ALA151H, ALA153H, ALA164H, ALA169H, ALA74C, ARG79C, ASN145C, ASN145H, ASN149H, ASP134H, ASP137C, ASP137H, ASP141C, ASP146C, ASP146H, GLN130H, GLN163H, GLU156H, GLU75C, GLU78C, GLY140C, GLY84C, GLY85C, HIS158H, ILE147C, ILE155H, ILE159H, ILE81C, LEU172H, LEU80C, LEU83C, LYS152H, LYS157H, LYS171H, MET161H, MET76C, PHE133H, PHE148H, PRO170H, SER142C, SER154H, SER77C, THR144C, THR82C, TRP160H, VAL143C, VAL150C, VAL150H
• C-J: ALA126C, ALA151C, ALA153C, ALA164C, ALA169C, ALA74J, ARG79J, ASN145C, ASN145J, ASN149C, ASP134C, ASP137C, ASP137J, ASP141J, ASP146C, ASP146J, GLN130C, GLN163C, GLU156C, GLU75J, GLU78J, GLY140J, GLY84J, GLY85J, HIS158C, ILE147J, ILE155C, ILE159C, ILE81J, LEU172C, LEU22J, LEU80J, LEU83J, LYS152C, LYS157C, LYS171C, MET161C, MET76J, PHE133C, PHE148C, PRO170C, SER142J, SER154C, SER77J, THR144J, THR82J, TRP160C, VAL143J, VAL150C, VAL150J
• C-L: ALA164C, ALA169C, ARG51L, ARG53C, ARG53L, ASN108L, GLN163C, GLN168C, GLU112C, GLU113C, GLU165C, GLU165L, GLU64C, GLY167C, GLY52C, GLY52L, GLY54C, GLY54L, HIS158C, HIS47L, HIS59L, ILE111C, ILE111L, ILE57C, ILE57L, LEU115C, LEU162C, LEU166C, LYS157C, LYS171C, LYS61C, MET161C, MET50L, MET56C, MET56L, MET62C, PHE55C, PHE55L, PRO170C, PRO60C, PRO60L, THR110C, THR110L, TRP160C, TRP48L, TRP58C, TRP58L, TYR107L, TYR49L, TYR65C, VAL109L
• D-F: ALA126F, ALA151F, ALA153F, ALA164F, ALA169F, ALA74D, ARG79D, ASN145D, ASN145F, ASN149F, ASP134F, ASP137D, ASP137F, ASP141D, ASP146D, ASP146F, GLN130F, GLN163F, GLU138D, GLU138F, GLU156F, GLU75D, GLU78D, GLY140D, GLY84D, GLY85D, HIS158F, ILE147D, ILE155F, ILE159F, ILE81D, LEU172F, LEU22D, LEU80D, LEU83D, LYS152F, LYS157F, LYS171F, MET161F, MET76D, PHE133F, PHE148F, PRO170F, SER136D, SER142D, SER154F, SER77D, THR144D, THR82D, TRP160F, VAL143D, VAL150D, VAL150F
• D-G: ALA164G, ALA169G, ARG51D, ARG53D, ARG53G, ASN108D, GLN163G, GLN168G, GLU112G, GLU113G, GLU165D, GLU165G, GLU64G, GLY167G, GLY52D, GLY52G, GLY54D, GLY54G, HIS158G, HIS47D, HIS59D, ILE111D, ILE111G, ILE57D, ILE57G, LEU115G, LEU162G, LEU166G, LYS157G, LYS171G, LYS61G, MET161G, MET50D, MET56D, MET56G, MET62G, PHE55D, PHE55G, PRO170G, PRO60D, PRO60G, THR110D, THR110G, TRP160G, TRP48D, TRP58D, TRP58G, TYR107D, TYR49D, TYR65G
• D-I: ALA164D, ALA169D, ARG51I, ARG53D, ARG53I, ASN108I, GLN163D, GLN168D, GLU112D, GLU113D, GLU165D, GLU165I, GLU64D, GLY167D, GLY52D, GLY52I, GLY54D, GLY54I, HIS158D, HIS47I, HIS59I, ILE111D, ILE111I, ILE57D, ILE57I, LEU115D, LEU162D, LEU166D, LYS157D, LYS171D, LYS61D, MET161D, MET50I, MET56D, MET56I, MET62D, PHE55D, PHE55I, PRO170D, PRO60I, THR110D, THR110I, TRP160D, TRP48I, TRP58D, TRP58I, TYR107I, TYR49I, TYR65D
• D-K: ALA126D, ALA151D, ALA153D, ALA164D, ALA169D, ALA74K, ARG79K, ASN145D, ASN145K, ASN149D, ASP134D, ASP137D, ASP137K, ASP141K, ASP146D, ASP146K, GLN130D, GLN163D, GLU156D, GLU75K, GLU78K, GLY140K, GLY84K, GLY85K, HIS158D, ILE147K, ILE155D, ILE159D, ILE81K, LEU172D, LEU80K, LEU83K, LYS152D, LYS157D, LYS171D, MET161D, MET76K, PHE133D, PHE148D, PRO170D, SER142K, SER154D, SER77K, THR144K, THR82K, TRP160D, VAL143K, VAL150D, VAL150K
• E-G: ALA34E, ALA34G, ALA39E, ALA39G, ALA74E, ALA74G, ALA86E, ALA86G, ARG51E, ARG51G, ASN30E, ASN30G, ASN97E, ASN97G, ASP106E, ASP106G, ASP35E, ASP35G, ASP63E, ASP63G, ASP70E, ASP70G, GLN45E, GLN45G, GLU102E, GLU102G, GLU67E, GLU67G, GLU78E, GLU78G, GLU93E, GLU93G, GLU96E, GLU96G, GLY105E, GLY105G, GLY84E, GLY84G, GLY85E, GLY85G, HIS40E, HIS40G, HIS44E, HIS44G, HIS47E, HIS47G, HIS59E, HIS59G, ILE42E, ILE42G, ILE81E, ILE81G, LEU104E, LEU104G, LEU36E, LEU36G, LEU43E, LEU43G, LEU73E, LEU73G, LEU80E, LEU80G, LEU83G, LEU91E, LEU91G, LYS101E, LYS101G, LYS92E, LYS92G, MET50E, MET50G, MET76E, MET76G, PHE55E, PHE55G, PHE88E, PHE88G, PHE94E, PHE94G, PRO87E, PRO87G, SER37E, SER37G, SER41E, SER41G, SER77E, SER77G, SER89E, SER89G, SER95E, SER95G, SER98E, SER98G, THR82E, THR82G, THR90E, THR90G, TRP48E, TRP48G, TYR107E, TYR107G, TYR49E, TYR49G, TYR72E, VAL103E, VAL103G, VAL33E, VAL33G, VAL38E, VAL38G, VAL46E, VAL46G
• E-I: ALA126I, ALA151I, ALA153I, ALA164I, ALA169I, ALA74E, ARG79E, ASN145E, ASN145I, ASN149I, ASP134I, ASP137E, ASP141E, ASP146E, ASP146I, GLN130I, GLN163I, GLU156I, GLU75E, GLU78E, GLY140E, GLY84E, GLY85E, HIS158I, ILE147E, ILE155I, ILE159I, ILE81E, LEU172I, LEU80E, LEU83E, LYS152I, LYS157I, LYS171I, MET161I, MET76E, PHE129I, PHE133I, PHE148I, PRO170I, SER142E, SER154I, SER77E, THR144E, THR82E, TRP160I, VAL143E, VAL150E, VAL150I
• E-L: ALA164L, ALA169L, ARG51E, ARG53E, ARG53L, ASN108E, GLN163L, GLN168L, GLU112L, GLU113L, GLU165E, GLU165L, GLU64L, GLY167L, GLY52E, GLY52L, GLY54E, GLY54L, HIS158L, HIS47E, HIS59E, ILE111E, ILE111L, ILE57E, ILE57L, LEU115L, LEU162L, LEU166L, LYS157L, LYS171L, LYS61L, MET161L, MET50E, MET56E, MET56L, MET62L, PHE55E, PHE55L, PRO170L, PRO60E, PRO60L, THR110E, THR110L, TRP160L, TRP48E, TRP58E, TRP58L, TYR107E, TYR49E, TYR65L
• F-H: ALA34F, ALA34H, ALA39F, ALA39H, ALA74F, ALA74H, ALA86F, ALA86H, ARG117H, ARG51F, ARG51H, ASN30F, ASN30H, ASN97F, ASN97H, ASP106F, ASP106H, ASP35F, ASP35H, ASP63F, ASP63H, ASP70F, ASP70H, GLN45F, GLN45H, GLU102F, GLU102H, GLU67F, GLU67H, GLU78F, GLU78H, GLU93F, GLU93H, GLU96F, GLU96H, GLY105F, GLY105H, GLY84F, GLY84H, GLY85F, GLY85H, HIS40F, HIS40H, HIS44F, HIS44H, HIS47F, HIS47H, HIS59F, HIS59H, ILE42F, ILE42H, ILE81F, ILE81H, LEU104F, LEU104H, LEU36F, LEU36H, LEU43F, LEU43H, LEU73F, LEU73H, LEU80F, LEU80H, LEU91F, LEU91H, LYS101F, LYS101H, LYS92F, LYS92H, MET50F, MET50H, MET66F, MET76F, MET76H, PHE55F, PHE55H, PHE88F, PHE88H, PHE94F, PHE94H, PRO87F, PRO87H, SER37F, SER37H, SER41F, SER41H, SER77F, SER77H, SER89F, SER89H, SER95F, SER95H, SER98F, SER98H, THR82F, THR82H, THR90F, THR90H, TRP48F, TRP48H, TYR107F, TYR107H, TYR49F, TYR49H, TYR72F, TYR72H, VAL103F, VAL103H, VAL33F, VAL33H, VAL38F, VAL38H, VAL46F, VAL46H
• F-J: ALA164J, ALA169J, ARG51F, ARG53F, ARG53J, ASN108F, GLN163J, GLN168J, GLU112J, GLU113J, GLU165F, GLU165J, GLU64J, GLY167J, GLY52F, GLY52J, GLY54F, GLY54J, HIS158J, HIS47F, HIS59F, ILE111F, ILE111J, ILE57F, ILE57J, LEU115J, LEU162J, LEU166J, LYS157J, LYS171J, LYS61J, MET161J, MET50F, MET56F, MET56J, MET62J, PHE55F, PHE55J, PRO170J, PRO60F, THR110F, THR110J, TRP160J, TRP48F, TRP58F, TRP58J, TYR107F, TYR49F, TYR65J, VAL109F
• F-K: ALA126K, ALA151K, ALA153K, ALA164K, ALA169K, ALA74F, ARG79F, ASN145F, ASN145K, ASN149K, ASP134K, ASP137F, ASP137K, ASP141F, ASP146F, ASP146K, GLN130K, GLN163K, GLU139F, GLU156K, GLU75F, GLU78F, GLY140F, GLY84F, GLY85F, HIS158K, ILE147F, ILE155K, ILE159K, ILE81F, LEU172K, LEU80F, LEU83F, LYS152K, LYS157K, LYS171K, LYS26F, MET161K, MET76F, PHE129K, PHE133K, PHE148K, PRO170K, SER142F, SER154K, SER77F, THR144F, THR82F, TRP160K, VAL143F, VAL150F, VAL150K
• G-I: ALA164I, ALA169I, ARG51G, ARG53G, ARG53I, ASN108G, GLN163I, GLN168I, GLU112I, GLU113I, GLU165G, GLU165I, GLU64I, GLY167I, GLY52G, GLY52I, GLY54G, GLY54I, HIS158I, HIS47G, HIS59G, ILE111G, ILE111I, ILE57G, ILE57I, LEU115I, LEU162I, LEU166I, LYS157I, LYS171I, LYS61I, MET161I, MET50G, MET56G, MET56I, MET62I, PHE55G, PHE55I, PRO170I, PRO60G, THR110G, THR110I, TRP160I, TRP48G, TRP58G, TRP58I, TYR107G, TYR49G, TYR65I
• G-L: ALA126L, ALA151L, ALA153L, ALA164L, ALA169L, ALA74G, ARG79G, ASN145G, ASN145L, ASN149L, ASP134L, ASP137G, ASP137L, ASP141G, ASP146G, ASP146L, GLN130L, GLN163L, GLU156L, GLU75G, GLU78G, GLY140G, GLY84G, GLY85G, HIS158L, ILE147G, ILE155L, ILE159L, ILE81G, LEU172L, LEU22G, LEU80G, LEU83G, LYS152L, LYS157L, LYS171L, MET161L, MET76G, PHE133L, PHE148L, PRO170L, SER142G, SER154L, SER77G, THR144G, THR82G, TRP160L, VAL143G, VAL150G, VAL150L
• H-J: ALA126J, ALA151J, ALA153J, ALA164J, ALA169J, ALA74H, ARG79H, ASN145H, ASN145J, ASN149J, ASP134J, ASP137H, ASP137J, ASP141H, ASP146H, ASP146J, GLN130J, GLN163J, GLU156J, GLU75H, GLU78H, GLY140H, GLY84H, GLY85H, HIS158J, ILE147H, ILE155J, ILE159J, ILE81H, LEU172J, LEU80H, LEU83H, LYS152J, LYS157J, LYS171J, MET161J, MET76H, PHE133J, PHE148J, PRO170J, SER142H, SER154J, SER77H, THR144H, THR82H, TRP160J, VAL143H, VAL150H, VAL150J
• H-K: ALA164K, ALA169K, ARG51H, ARG53H, ARG53K, ASN108H, GLN163K, GLN168K, GLU112K, GLU113K, GLU165H, GLU165K, GLU64K, GLY167K, GLY52H, GLY52K, GLY54H, GLY54K, HIS158K, HIS47H, HIS59H, ILE111H, ILE111K, ILE57H, ILE57K, LEU115K, LEU162K, LEU166K, LYS157K, LYS171K, LYS61K, MET161K, MET50H, MET56H, MET56K, MET62K, PHE55H, PHE55K, PRO170K, PRO60H, THR110H, THR110K, TRP160K, TRP48H, TRP58H, TRP58K, TYR107H, TYR49H, TYR65K, VAL109H
• I-K: ALA34I, ALA34K, ALA39I, ALA39K, ALA74I, ALA74K, ALA86I, ALA86K, ARG117K, ARG51I, ARG51K, ASN30I, ASN30K, ASN97I, ASN97K, ASP106I, ASP106K, ASP35K, ASP63I, ASP63K, ASP70I, ASP70K, GLN45I, GLN45K, GLU102I, GLU102K, GLU67I, GLU67K, GLU75K, GLU78I, GLU78K, GLU93I, GLU93K, GLU96I, GLU96K, GLY105I, GLY105K, GLY84I, GLY84K, GLY85I, GLY85K, HIS40I, HIS40K, HIS44I, HIS44K, HIS47I, HIS47K, HIS59I, HIS59K, ILE42I, ILE42K, ILE81I, ILE81K, LEU104I, LEU104K, LEU36I, LEU36K, LEU43I, LEU43K, LEU73I, LEU73K, LEU80I, LEU80K, LEU91I, LEU91K, LYS101I, LYS101K, LYS92I, LYS92K, MET50I, MET50K, MET76I, MET76K, PHE55I, PHE55K, PHE88I, PHE88K, PHE94I, PHE94K, PRO87I, PRO87K, SER37I, SER37K, SER41I, SER41K, SER77I, SER77K, SER89I, SER89K, SER95I, SER95K, SER98I, SER98K, THR82I, THR82K, THR90I, THR90K, TRP48I, TRP48K, TYR107I, TYR107K, TYR49I, TYR49K, TYR72I, VAL103I, VAL103K, VAL33I, VAL33K, VAL38I, VAL38K, VAL46I, VAL46K
• J-L: ALA34J, ALA34L, ALA39J, ALA39L, ALA74J, ALA74L, ALA86J, ALA86L, ARG117J, ARG117L, ARG51J, ARG51L, ASN30J, ASN30L, ASN97J, ASN97L, ASP106J, ASP106L, ASP35J, ASP35L, ASP63J, ASP63L, ASP70J, ASP70L, GLN45J, GLN45L, GLU102J, GLU102L, GLU75J, GLU75L, GLU78J, GLU78L, GLU93J, GLU93L, GLU96J, GLU96L, GLY105J, GLY105L, GLY84J, GLY84L, GLY85J, GLY85L, HIS40J, HIS40L, HIS44J, HIS44L, HIS47J, HIS47L, HIS59J, HIS59L, ILE42J, ILE42L, ILE81J, ILE81L, LEU104J, LEU104L, LEU36J, LEU36L, LEU43J, LEU43L, LEU73J, LEU73L, LEU80J, LEU80L, LEU83J, LEU83L, LEU91J, LEU91L, LYS101J, LYS101L, LYS92J, LYS92L, MET50J, MET50L, MET66J, MET66L, MET76J, MET76L, PHE55J, PHE55L, PHE88J, PHE88L, PHE94J, PHE94L, PRO87J, PRO87L, SER37J, SER37L, SER41J, SER41L, SER77J, SER77L, SER89J, SER89L, SER95J, SER95L, SER98J, SER98L, THR82J, THR82L, THR90J, THR90L, TRP48J, TRP48L, TYR107J, TYR107L, TYR49J, TYR49L, TYR72L, VAL103J, VAL103L, VAL33J, VAL33L, VAL38J, VAL38L, VAL46J, VAL46L