2CF2

architecture of mammalian fatty acid synthase

• Total interactions analyzed: 45
• Total true interactions: 14
• Strongest Interaction:
  • Chains: D-L
  • Int. Res.: 15
  • Norm. En. per Res.: -0.1497
• Hub Node: C(5)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-C	0.0	0.0	613.016	613.016	41	63	0	1834	0	0	0
A-J	0.0	0.0	-12.9286	-12.9286	128	0	0	2491	0	0	0
A-L	0.0	0.0	69.8209	69.8209	54	56	0	1419	0	0	0
C-D	0.0	0.0	11.0882	11.0882	21	10	0	368	0	0	0
C-J	0.0	0.0	18.8634	18.8634	24	27	0	535	0	0	0
C-L	0.0	0.0	465.326	465.326	97	138	0	4301	0	0	0
C-M	0.0	0.0	-1.2857	-1.2857	11	0	0	159	0	0	0
C-N	0.0	0.0	9.1236	9.1236	33	8	0	624	0	0	0
D-L	0.0	0.0	-2.2458	-2.2458	15	0	0	208	0	0	0
D-M	0.0	0.0	-4.8937	-4.8937	44	0	0	926	0	0	0
D-N	0.0	0.0	-0.2476	-0.2476	15	0	0	103	0	0	0
E-L	0.0	0.0	17.0692	17.0692	30	8	0	533	0	0	0
J-L	0.0	0.0	249.187	249.187	53	125	0	2653	0	0	0
L-M	0.0	0.0	28.1418	28.1418	16	13	0	351	0	0	0

Interface residues

• A-C: ALA1014C, ALA1056C, ALA117A, ALA119A, ALA128A, ARG1004C, ARG1038C, ARG121A, ARG124A, ASP1011C, ASP118A, GLU1005C, GLU1010C, GLU1055C, GLY116A, GLY122A, GLY125A, GLY130A, LEU1012C, LEU1013C, LEU1020C, LEU1089C, LEU126A, LYS1003C, LYS1009C, LYS1041C, LYS127A, MET1042C, MET120A, PHE1092C, PRO123A, SER1006C, SER1015C, THR1008C, THR1043C, TYR1007C, TYR1093C, VAL1039C, VAL1040C, VAL1054C, VAL129A
• A-J: ALA117A, ALA117J, ALA137A, ALA139A, ALA139J, ALA144A, ALA144J, ALA147A, ALA147J, ALA162A, ALA162J, ALA203A, ALA203J, ALA262A, ALA262J, ALA267A, ALA267J, ASN156A, ASN156J, ASN95A, ASN95J, ASP202A, ASP202J, ASP265A, ASP265J, ASP268A, ASP268J, CYS145A, CYS145J, CYS199A, CYS199J, GLN113A, GLN113J, GLU196A, GLU196J, GLU200A, GLU200J, GLY106A, GLY106J, GLY107A, GLY107J, GLY108A, GLY108J, GLY116A, GLY116J, GLY125A, GLY125J, GLY130A, GLY130J, GLY141A, GLY141J, GLY154A, GLY154J, GLY266A, GLY266J, GLY393A, GLY393J, GLY394A, GLY394J, GLY43A, GLY43J, HIS153A, HIS153J, ILE152A, ILE152J, ILE159A, ILE159J, LEU126A, LEU126J, LEU179A, LEU179J, LYS127A, LYS127J, LYS151A, LYS151J, MET120A, MET120J, MET138A, MET138J, MET197J, MET204A, MET204J, MET269A, MET269J, PHE150A, PHE201A, PHE392A, PHE392J, PRO110A, PRO110J, PRO131A, PRO131J, PRO149A, PRO149J, PRO97J, SER140A, SER140J, SER143A, SER143J, SER158A, SER158J, SER160A, SER160J, SER161A, SER161J, SER264A, SER264J, THR135A, THR135J, THR148A, THR148J, THR263A, THR263J, THR395A, THR395J, TYR132J, TYR157A, TYR157J, VAL114A, VAL114J, VAL129A, VAL129J, VAL133A, VAL133J, VAL134A, VAL134J, VAL155A, VAL155J
• A-L: ALA1014L, ALA1023L, ALA119A, ALA203A, ARG1004L, ARG1017L, ARG121A, ARG45A, ASP1002L, ASP1011L, ASP118A, ASP202A, ASP41A, CYS194A, CYS199A, GLN1027L, GLN37A, GLU1005L, GLU1010L, GLU1019L, GLU1100L, GLU196A, GLU200A, GLU38A, GLY1016L, GLY1018L, GLY1022L, GLY1025L, GLY1095L, GLY1098L, GLY1099L, GLY122A, GLY43A, HIS47A, LEU1013L, LEU1020L, LEU39A, LYS1003L, LYS1024L, LYS1041L, LYS40A, MET44A, PHE1021L, PHE115A, PRO1026L, SER1006L, SER1015L, SER42A, SER46A, TRP1096L, TRP195A, VAL1001L, VAL1040L, VAL114A
• C-D: ALA48D, ARG2136C, ARG2137C, ARG52D, ARG8D, ASN2135C, ASP2167C, GLN2166C, GLY10D, GLY47D, HIS54D, ILE2139C, LEU2138C, LEU46D, LEU50D, LEU53D, LEU9D, MET44D, PRO55D, THR51D, TYR49D
• C-J: ALA203J, ARG1004C, ARG45J, ASP1002C, ASP1011C, ASP41J, CYS199J, GLU1019C, GLU196J, GLU38J, GLY1022C, GLY1098C, GLY43J, LEU1020C, LEU1097C, LEU39J, LYS1003C, LYS40J, MET44J, PHE1021C, SER42J, TRP1096C, TRP195J, VAL1001C
• C-L: ALA1056C, ALA1056L, ALA1143C, ALA1143L, ALA1157C, ALA1157L, ARG1127C, ARG1127L, ARG1132C, ARG1132L, ARG1152C, ARG1152L, ASN1048C, ASN1048L, ASP1050C, ASP1050L, ASP1144C, ASP1144L, GLU1005C, GLU1005L, GLU1044C, GLU1044L, GLU1055C, GLU1055L, GLU1057C, GLU1057L, GLU1146C, GLU1146L, GLY1046C, GLY1046L, GLY1047C, GLY1047L, GLY1052C, GLY1052L, GLY1082C, GLY1145C, GLY1145L, GLY1151C, GLY1151L, HIS1129C, HIS1129L, ILE1128C, ILE1128L, ILE1133C, ILE1133L, ILE1154C, LEU1058C, LEU1089C, LEU1148C, LEU1148L, LEU1153C, LEU1153L, LYS1041C, LYS1041L, LYS1051C, LYS1051L, LYS1131C, LYS1131L, MET1042C, MET1042L, MET1086C, MET1086L, PHE1049C, PHE1049L, PHE1130C, PHE1130L, SER1006C, SER1006L, SER1158C, SER1158L, THR1043C, THR1043L, THR1045C, THR1045L, THR1125C, THR1125L, THR1156C, THR1156L, TYR1053C, TYR1053L, TYR1126C, TYR1126L, TYR1155C, TYR1155L, VAL1039C, VAL1039L, VAL1040C, VAL1040L, VAL1054C, VAL1054L, VAL1124C, VAL1124L, VAL1134L, VAL1147C, VAL1147L, VAL1149C, VAL1149L
• C-M: ALA184M, ALA186M, ASN2048C, ASP2050C, GLU182M, GLY188M, GLY189M, LYS185M, LYS2131C, PHE2049C, TRP187M
• C-N: ALA2014C, ALA2023C, ALA20N, ALA212N, ALA44N, ARG15N, ARG19N, ARG2004C, ARG2017C, ASP2002C, ASP47N, GLN213N, GLU185N, GLU2019C, GLU214N, GLU23N, GLY16N, GLY2018C, GLY2022C, GLY211N, GLY50N, ILE17N, ILE45N, LEU2020C, LEU49N, LYS2003C, LYS2024C, PHE2021C, SER14N, SER46N, THR186N, TYR48N, VAL2001C
• D-L: ALA184D, ALA186D, ARG183D, ASN2048L, ASP2050L, GLU182D, GLY188D, GLY189D, GLY206D, LYS185D, LYS2051L, LYS2131L, PHE2049L, PRO181D, TRP187D
• D-M: ALA225D, ALA225M, ALA238D, ALA238M, ARG231D, ARG234D, ARG234M, ARG235D, ARG235M, ASN236D, ASN236M, GLY241D, GLY241M, ILE217M, ILE227D, ILE227M, LEU230D, LEU232D, LEU232M, LEU237D, LEU237M, LEU240D, LEU240M, LEU247M, LEU50D, LEU50M, MET233D, MET233M, PHE242D, PHE242M, PRO226D, PRO226M, PRO228D, PRO228M, PRO229D, PRO229M, PRO246D, PRO246M, TRP243D, TRP243M, TYR216D, TYR216M, VAL239D, VAL239M
• D-N: ARG28N, ASN2N, ASP17D, ASP225N, GLU226N, GLU22D, GLU4N, GLY5N, LEU18D, MET1N, PHE3N, PHE57D, PRO19D, PRO56D, VAL16D
• E-L: ALA2014L, ALA2023L, ALA20E, ALA212E, ALA44E, ARG15E, ARG2004L, ARG2017L, ASP2002L, ASP47E, GLN213E, GLU185E, GLU2019L, GLU214E, GLU23E, GLY16E, GLY2018L, GLY2022L, GLY211E, GLY50E, ILE45E, LEU2020L, LEU49E, LYS2003L, LYS2024L, PHE2021L, SER46E, THR186E, TYR48E, VAL2001L
• J-L: ALA1014L, ALA1030L, ALA1056L, ALA1085L, ALA117J, ALA119J, ALA128J, ARG1004L, ARG1017L, ARG1038L, ARG121J, ARG124J, ASP1011L, ASP1037L, ASP118J, GLN1027L, GLN1088L, GLU1005L, GLU1010L, GLU1019L, GLY1016L, GLY1018L, GLY116J, GLY122J, GLY125J, GLY130J, LEU1012L, LEU1013L, LEU1020L, LEU1028L, LEU1034L, LEU1089L, LEU126J, LYS1009L, LYS127J, MET1035L, MET1036L, MET120J, PHE1092L, PHE115J, PRO1029L, PRO1031L, PRO123J, PRO131J, SER1006L, SER1015L, THR1008L, TYR1007L, VAL1039L, VAL1040L, VAL114J, VAL129J, VAL133J
• L-M: ALA48M, ARG2136L, ARG2137L, ARG52M, ASP2167L, GLN2166L, GLY47M, HIS54M, LEU2138L, LEU46M, LEU50M, LEU53M, LEU9M, MET44M, THR51M, TYR49M