2CE3

crystal structure of the atp-dependent clp protease proteolytic subunit 1 (clpp1) from mycobacterium tuberculosis

• Total interactions analyzed: 91
• Total true interactions: 28
• Strongest Interaction:
  • Chains: D-E
  • Int. Res.: 124
  • Norm. En. per Res.: -3.5339
• Hub Node: A(4)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-37.2334	-63.3532	-267.111	-367.6976	119	9	12	11962	5	20	21
A-G	-44.8174	-75.8027	-276.634	-397.2542	120	15	11	11889	6	19	21
A-I	0.0	0.0	-38.5954	-38.5954	26	1	9	1992	0	1	1
A-J	0.0	5.2731	-0.0419	5.2312	5	0	0	14	0	12	9
B-C	-29.1373	-70.9394	-266.101	-366.1777	114	13	12	12321	6	21	21
B-F	0.0	0.0	-0.2569	-0.2569	2	0	0	22	0	0	0
B-H	0.0	0.0	-31.6033	-31.6033	25	0	9	1758	0	0	1
B-I	0.0	5.6148	-0.3523	5.2625	8	0	0	62	0	14	11
C-D	-33.4984	-72.7733	-264.337	-370.6086	115	6	12	11454	6	19	21
C-N	0.0	0.0	-16.6751	-16.6751	23	0	8	1156	0	0	1
D-E	-52.503	-85.2083	-300.492	-438.2034	124	15	14	12859	6	22	22
D-M	0.0	0.0	-17.8748	-17.8748	23	0	8	1485	0	0	1
D-N	0.0	7.6808	-0.0811	7.5998	4	0	0	15	0	6	6
E-F	-29.354	-69.553	-287.742	-386.649	117	8	12	12317	6	21	21
E-L	0.0	0.0	-30.5644	-30.5644	23	0	10	1753	0	1	1
E-M	0.0	5.3071	-0.1241	5.183	6	0	0	33	0	13	11
F-G	-33.6402	-65.1144	-269.494	-368.2486	113	18	12	12013	6	21	21
F-K	0.0	0.0	-28.3498	-28.3498	23	0	9	1723	0	0	1
F-L	0.0	7.7244	-0.3641	7.3604	7	0	0	36	0	12	9
G-J	0.0	0.0	-21.6919	-21.6919	26	0	9	1493	0	0	1
G-K	0.0	4.102	-0.0815	4.0205	4	0	0	16	0	12	9
H-I	-28.531	-69.1018	-269.643	-367.2757	120	11	12	11911	6	20	21
H-N	-33.1111	-65.2316	-261.838	-360.1807	115	11	12	11589	6	19	21
I-J	-42.0404	-61.8498	-275.742	-379.6322	123	13	12	12199	5	22	21
J-K	-39.6622	-67.2763	-257.515	-364.4535	115	10	12	11750	6	21	21
K-L	-54.993	-64.8241	-294.426	-414.2432	123	20	16	12985	5	23	22
L-M	-34.124	-59.0312	-273.971	-367.1261	117	9	12	11954	5	20	22
M-N	-24.6036	-68.6203	-280.156	-373.38	114	12	12	12299	6	21	21

Interface residues

• A-B: ALA114B, ALA118B, ALA137A, ALA140A, ALA144A, ALA177B, ALA41A, ALA46A, ALA52A, ALA53A, ALA73A, ALA76A, ALA84A, ALA92B, ALA97B, ARG119B, ARG152A, ARG171B, ARG173B, ARG23A, ARG23B, ARG28A, ARG28B, ARG43A, ASN37A, ASN42A, ASN65B, ASP172B, ASP18A, ASP18B, ASP38A, ASP79A, CYS45A, GLN139A, GLN142A, GLN47A, GLU141A, GLU149A, GLU179B, GLU22A, GLU22B, GLU27A, GLU27B, GLU39A, GLU54A, GLY33B, GLY74A, GLY94B, HIS117B, HIS123B, ILE120B, ILE138A, ILE146A, ILE190B, ILE29B, ILE30A, ILE30B, ILE40A, ILE48A, ILE64B, ILE71A, ILE77A, LEU115B, LEU121B, LEU153A, LEU16B, LEU24A, LEU24B, LEU25A, LEU25B, LEU32B, LEU44A, LEU49A, LEU50A, LEU51A, LEU83A, LYS148A, MET122B, MET150A, MET75A, MET81A, MET93B, MET95B, PHE102A, PHE143A, PHE157A, PHE175B, PHE31A, PHE31B, PRO116B, PRO67B, PRO85A, SER15A, SER15B, SER19A, SER19B, SER26A, SER26B, SER34B, SER61B, SER66B, SER70A, SER72A, THR176B, THR17A, THR17B, THR191B, THR80A, TRP174B, TYR113B, TYR21A, TYR21B, TYR63B, TYR78A, TYR91B, VAL145A, VAL20A, VAL20B, VAL82A
• A-G: ALA114A, ALA118A, ALA137G, ALA140G, ALA144G, ALA177A, ALA41G, ALA46G, ALA52G, ALA53G, ALA73G, ALA76G, ALA84G, ALA92A, ALA97A, ARG119A, ARG152G, ARG171A, ARG173A, ARG23A, ARG23G, ARG28G, ARG43G, ASN37G, ASN42G, ASN65A, ASP172A, ASP18A, ASP18G, ASP38G, ASP79G, CYS45G, GLN139G, GLN142G, GLN47G, GLU141G, GLU149G, GLU179A, GLU22A, GLU22G, GLU27A, GLU27G, GLU39G, GLU54G, GLY33A, GLY74G, GLY94A, HIS117A, HIS123A, ILE120A, ILE136G, ILE138G, ILE146G, ILE189A, ILE190A, ILE29A, ILE30A, ILE30G, ILE40G, ILE48G, ILE64A, ILE71G, ILE77G, LEU115A, LEU121A, LEU153G, LEU16A, LEU24A, LEU24G, LEU25A, LEU25G, LEU32A, LEU44G, LEU49G, LEU50G, LEU51G, LEU83G, LYS147G, MET122A, MET150G, MET75G, MET81G, MET93A, MET95A, PHE102G, PHE143G, PHE157G, PHE175A, PHE31A, PHE31G, PRO116A, PRO67A, PRO85G, SER15A, SER15G, SER19A, SER19G, SER26A, SER26G, SER34A, SER61A, SER66A, SER70G, SER72G, THR176A, THR17A, THR17G, THR191A, THR80G, TRP174A, TYR113A, TYR21A, TYR21G, TYR63A, TYR78G, TYR91A, VAL145G, VAL20A, VAL20G, VAL82G
• A-I: ALA137A, ALA137I, ALA140A, ALA140I, ALA144A, ALA144I, GLN124A, GLN139A, GLN139I, GLN142A, GLN142I, GLU141A, GLU141I, ILE136A, ILE136I, ILE138A, ILE138I, ILE146I, ILE71A, ILE71I, LYS147A, LYS147I, PHE143A, PHE143I, PRO125A, PRO125I
• A-J: ARG171A, ARG171J, ASP170A, ASP170J, GLN124A
• B-C: ALA114C, ALA118C, ALA140B, ALA144B, ALA177C, ALA41B, ALA46B, ALA52B, ALA53B, ALA73B, ALA76B, ALA84B, ALA92C, ARG119C, ARG152B, ARG171C, ARG173C, ARG23B, ARG23C, ARG28B, ARG28C, ARG43B, ASN37B, ASN42B, ASN65C, ASP172C, ASP18B, ASP18C, ASP38B, ASP79B, CYS45B, GLN139B, GLN142B, GLN47B, GLU141B, GLU149B, GLU179C, GLU22B, GLU22C, GLU27B, GLU27C, GLU39B, GLU54B, GLY33C, GLY94C, HIS117C, ILE120C, ILE138B, ILE146B, ILE190C, ILE29C, ILE30B, ILE30C, ILE40B, ILE48B, ILE64C, ILE71B, ILE77B, LEU115C, LEU121C, LEU153B, LEU16C, LEU24B, LEU24C, LEU25B, LEU25C, LEU32C, LEU44B, LEU49B, LEU50B, LEU51B, LEU83B, LYS148B, MET150B, MET75B, MET81B, MET93C, MET95C, PHE102B, PHE143B, PHE157B, PHE175C, PHE31B, PHE31C, PRO116C, PRO67C, PRO85B, SER15B, SER15C, SER19B, SER19C, SER26B, SER26C, SER34C, SER61C, SER66C, SER70B, SER72B, THR176C, THR17B, THR17C, THR191C, THR80B, TRP174C, TYR113C, TYR21B, TYR21C, TYR63C, TYR78B, TYR91C, VAL145B, VAL20B, VAL20C, VAL82B
• B-F: HIS1B, LYS58F
• B-H: ALA137B, ALA137H, ALA140B, ALA140H, ALA144B, ALA144H, GLN124H, GLN139B, GLN139H, GLN142B, GLN142H, GLU141B, GLU141H, ILE136B, ILE136H, ILE138B, ILE138H, ILE71B, ILE71H, LYS147B, LYS147H, PHE143B, PHE143H, PRO125B, PRO125H
• B-I: ARG171B, ARG171I, ASP170B, ASP170I, ASP172B, ASP172I, GLN124B, GLN124I
• C-D: ALA114D, ALA118D, ALA140C, ALA144C, ALA177D, ALA41C, ALA46C, ALA52C, ALA53C, ALA73C, ALA76C, ALA84C, ALA92D, ALA97D, ARG119D, ARG152C, ARG171D, ARG173D, ARG23C, ARG23D, ARG28C, ARG43C, ASN37C, ASN42C, ASN65D, ASP172D, ASP18C, ASP18D, ASP38C, ASP79C, CYS45C, GLN139C, GLN142C, GLN47C, GLU141C, GLU149C, GLU22C, GLU22D, GLU27C, GLU27D, GLU39C, GLU54C, GLY33D, GLY94D, HIS117D, ILE120D, ILE136C, ILE138C, ILE146C, ILE189D, ILE190D, ILE29D, ILE30C, ILE30D, ILE40C, ILE48C, ILE64D, ILE71C, ILE77C, LEU115D, LEU121D, LEU153C, LEU16D, LEU24C, LEU24D, LEU25C, LEU25D, LEU32D, LEU44C, LEU49C, LEU50C, LEU51C, LEU83C, MET122D, MET150C, MET75C, MET81C, MET93D, MET95D, PHE102C, PHE143C, PHE157C, PHE175D, PHE31C, PHE31D, PRO116D, PRO67D, PRO85C, SER15C, SER15D, SER19C, SER19D, SER26C, SER26D, SER34D, SER61D, SER66D, SER70C, SER72C, THR176D, THR17C, THR17D, THR191D, THR80C, TRP174D, TYR113D, TYR21C, TYR21D, TYR63D, TYR78C, TYR91D, VAL145C, VAL20C, VAL20D, VAL82C
• C-N: ALA137C, ALA137N, ALA140C, ALA140N, ALA144C, ALA144N, GLN124C, GLN124N, GLN139C, GLN139N, GLU141C, GLU141N, ILE136C, ILE136N, ILE138C, ILE138N, ILE71N, LYS147C, LYS147N, PHE143C, PHE143N, PRO125C, PRO125N
• D-E: ALA114E, ALA118E, ALA137D, ALA140D, ALA144D, ALA177E, ALA193E, ALA41D, ALA46D, ALA52D, ALA53D, ALA56D, ALA73D, ALA76D, ALA84D, ALA92E, ALA97E, ARG119E, ARG152D, ARG171E, ARG173E, ARG192E, ARG23D, ARG23E, ARG28D, ARG28E, ARG43D, ASN37D, ASN42D, ASN65E, ASP172E, ASP18D, ASP18E, ASP38D, ASP55D, ASP79D, ASP87D, CYS45D, CYS86D, GLN139D, GLN142D, GLN47D, GLU141D, GLU149D, GLU179E, GLU22D, GLU22E, GLU27D, GLU27E, GLU39D, GLU54D, GLY33E, GLY74D, GLY94E, HIS117E, ILE120E, ILE136D, ILE138D, ILE146D, ILE190E, ILE29E, ILE30D, ILE30E, ILE40D, ILE48D, ILE64E, ILE71D, ILE77D, LEU115E, LEU121E, LEU153D, LEU16E, LEU24D, LEU24E, LEU25D, LEU25E, LEU32E, LEU44D, LEU49D, LEU50D, LEU51D, LEU83D, MET122E, MET150D, MET75D, MET81D, MET93E, MET95E, PHE102D, PHE143D, PHE157D, PHE175E, PHE31D, PHE31E, PRO116E, PRO67E, PRO85D, SER15D, SER15E, SER19D, SER19E, SER26D, SER26E, SER34E, SER61E, SER66E, SER70D, SER72D, THR176E, THR17D, THR17E, THR191E, THR80D, TRP174E, TYR113E, TYR21D, TYR21E, TYR63E, TYR78D, TYR91E, VAL145D, VAL20D, VAL20E, VAL82D
• D-M: ALA137D, ALA137M, ALA140D, ALA140M, ALA144D, ALA144M, GLN124D, GLN139D, GLN139M, GLN142D, GLU141D, GLU141M, ILE136D, ILE136M, ILE138D, ILE138M, ILE71M, LYS147D, LYS147M, PHE143D, PHE143M, PRO125D, PRO125M
• D-N: ARG171D, ARG171N, ASP170D, ASP170N
• E-F: ALA114F, ALA118F, ALA137E, ALA140E, ALA144E, ALA177F, ALA41E, ALA46E, ALA52E, ALA53E, ALA73E, ALA76E, ALA84E, ALA92F, ALA97F, ARG119F, ARG152E, ARG171F, ARG173F, ARG23E, ARG23F, ARG28E, ARG43E, ASN42E, ASN65F, ASP172F, ASP18E, ASP18F, ASP38E, ASP79E, CYS45E, GLN139E, GLN142E, GLN47E, GLU141E, GLU149E, GLU179F, GLU22E, GLU22F, GLU27E, GLU27F, GLU35F, GLU39E, GLU54E, GLY33F, GLY94F, HIS117F, HIS123F, ILE120F, ILE136E, ILE138E, ILE146E, ILE190F, ILE29F, ILE30E, ILE30F, ILE40E, ILE48E, ILE64F, ILE71E, ILE77E, LEU115F, LEU121F, LEU153E, LEU16F, LEU24E, LEU24F, LEU25E, LEU25F, LEU32F, LEU44E, LEU49E, LEU50E, LEU51E, LEU83E, MET122F, MET150E, MET75E, MET81E, MET93F, MET95F, PHE102E, PHE143E, PHE157E, PHE175F, PHE31E, PHE31F, PRO116F, PRO67F, PRO85E, SER15E, SER15F, SER19E, SER19F, SER26E, SER26F, SER34F, SER61F, SER66F, SER70E, SER72E, THR176F, THR17E, THR17F, THR191F, THR80E, TRP174F, TYR113F, TYR21E, TYR21F, TYR63F, TYR78E, TYR91F, VAL145E, VAL20E, VAL20F, VAL82E
• E-L: ALA137E, ALA137L, ALA140E, ALA140L, ALA144E, ALA144L, GLN139E, GLN139L, GLN142E, GLN142L, GLU141E, GLU141L, ILE136E, ILE136L, ILE138E, ILE138L, ILE71E, LYS147E, LYS147L, PHE143E, PHE143L, PRO125E, PRO125L
• E-M: ARG171E, ARG171M, ASP170E, ASP170M, ASP172M, GLN124E
• F-G: ALA114G, ALA118G, ALA137F, ALA140F, ALA144F, ALA177G, ALA41F, ALA46F, ALA52F, ALA53F, ALA73F, ALA76F, ALA84F, ALA92G, ALA97G, ARG119G, ARG152F, ARG171G, ARG173G, ARG23F, ARG23G, ARG28F, ARG43F, ASN42F, ASN65G, ASP172G, ASP18F, ASP18G, ASP38F, ASP79F, CYS45F, GLN139F, GLN142F, GLN47F, GLU141F, GLU149F, GLU179G, GLU22F, GLU22G, GLU27G, GLU39F, GLU54F, GLY33G, GLY94G, HIS117G, ILE120G, ILE138F, ILE146F, ILE190G, ILE29F, ILE29G, ILE30F, ILE30G, ILE40F, ILE48F, ILE71F, ILE77F, LEU115G, LEU121G, LEU153F, LEU16G, LEU24F, LEU24G, LEU25F, LEU25G, LEU32G, LEU44F, LEU49F, LEU50F, LEU51F, LEU83F, MET122G, MET150F, MET75F, MET81F, MET93G, MET95G, PHE102F, PHE143F, PHE157F, PHE175G, PHE31F, PHE31G, PRO116G, PRO67G, PRO85F, SER15F, SER15G, SER19F, SER19G, SER26F, SER26G, SER34G, SER61G, SER66G, SER70F, SER72F, THR176G, THR17F, THR17G, THR191G, THR80F, TRP174G, TYR113G, TYR21F, TYR21G, TYR63G, TYR78F, TYR91G, VAL145F, VAL20F, VAL20G, VAL82F
• F-K: ALA137F, ALA137K, ALA140F, ALA140K, ALA144F, ALA144K, GLN139F, GLN139K, GLN142F, GLN142K, GLU141F, GLU141K, ILE136F, ILE136K, ILE138F, ILE138K, ILE71K, LYS147F, LYS147K, PHE143F, PHE143K, PRO125F, PRO125K
• F-L: ARG171F, ARG171L, ASP170F, ASP170L, ASP172F, GLN124F, GLN124L
• G-J: ALA137G, ALA137J, ALA140G, ALA140J, ALA144G, ALA144J, GLN124G, GLN124J, GLN139G, GLN139J, GLN142G, GLN142J, GLU141G, GLU141J, ILE136G, ILE136J, ILE138G, ILE138J, ILE71G, ILE71J, LYS147G, LYS147J, PHE143G, PHE143J, PRO125G, PRO125J
• G-K: ARG171G, ARG171K, ASP170G, ASP170K
• H-I: ALA114I, ALA118I, ALA137H, ALA140H, ALA144H, ALA177I, ALA41H, ALA46H, ALA52H, ALA53H, ALA73H, ALA76H, ALA84H, ALA92I, ALA97I, ARG119I, ARG152H, ARG171I, ARG173I, ARG23H, ARG23I, ARG28H, ARG28I, ARG43H, ASN37H, ASN42H, ASN65I, ASP172I, ASP18H, ASP18I, ASP38H, ASP55H, ASP79H, CYS45H, GLN139H, GLN142H, GLN47H, GLU141H, GLU149H, GLU179I, GLU22H, GLU22I, GLU27H, GLU27I, GLU39H, GLU54H, GLY33I, GLY74H, GLY94I, HIS117I, HIS123I, ILE120I, ILE136H, ILE138H, ILE146H, ILE190I, ILE29I, ILE30H, ILE30I, ILE40H, ILE48H, ILE64I, ILE71H, ILE77H, LEU115I, LEU121I, LEU153H, LEU16I, LEU24H, LEU24I, LEU25H, LEU25I, LEU32I, LEU44H, LEU49H, LEU50H, LEU51H, LEU83H, MET122I, MET150H, MET75H, MET81H, MET93I, MET95I, PHE102H, PHE143H, PHE157H, PHE175I, PHE31H, PHE31I, PRO116I, PRO67I, PRO85H, SER15H, SER15I, SER19H, SER19I, SER26H, SER26I, SER34I, SER61I, SER66I, SER70H, SER72H, THR176I, THR17H, THR17I, THR191I, THR80H, TRP174I, TYR113I, TYR21H, TYR21I, TYR63I, TYR78H, TYR91I, VAL145H, VAL20H, VAL20I, VAL82H
• H-N: ALA114H, ALA118H, ALA140N, ALA144N, ALA177H, ALA41N, ALA46N, ALA52N, ALA53N, ALA73N, ALA76N, ALA84N, ALA92H, ALA97H, ARG119H, ARG152N, ARG171H, ARG173H, ARG23H, ARG23N, ARG28N, ARG43N, ASN37N, ASN42N, ASN65H, ASP172H, ASP18H, ASP18N, ASP38N, ASP79N, CYS45N, GLN139N, GLN142N, GLN47N, GLU141N, GLU149N, GLU22H, GLU22N, GLU27H, GLU27N, GLU39N, GLU54N, GLY33H, GLY94H, HIS117H, HIS123H, ILE120H, ILE136N, ILE138N, ILE146N, ILE189H, ILE190H, ILE29H, ILE30H, ILE30N, ILE40N, ILE48N, ILE64H, ILE71N, ILE77N, LEU115H, LEU121H, LEU153N, LEU16H, LEU24H, LEU24N, LEU25H, LEU25N, LEU32H, LEU44N, LEU49N, LEU50N, LEU51N, LEU83N, MET122H, MET150N, MET75N, MET81N, MET93H, MET95H, PHE102N, PHE143N, PHE157N, PHE175H, PHE31H, PHE31N, PRO116H, PRO67H, PRO85N, SER15H, SER15N, SER19H, SER19N, SER26H, SER26N, SER34H, SER61H, SER66H, SER72N, THR176H, THR17H, THR17N, THR191H, THR80N, TRP174H, TYR113H, TYR21H, TYR21N, TYR63H, TYR78N, TYR91H, VAL145N, VAL20H, VAL20N, VAL82N
• I-J: ALA114J, ALA118J, ALA137I, ALA140I, ALA144I, ALA177J, ALA41I, ALA46I, ALA52I, ALA53I, ALA73I, ALA76I, ALA84I, ALA92J, ALA96J, ALA97J, ARG119J, ARG152I, ARG171J, ARG173J, ARG23I, ARG23J, ARG28I, ARG28J, ARG43I, ASN37I, ASN42I, ASN65J, ASP172J, ASP18I, ASP18J, ASP38I, ASP55I, ASP79I, CYS45I, GLN139I, GLN142I, GLN47I, GLU141I, GLU149I, GLU179J, GLU22I, GLU22J, GLU27I, GLU27J, GLU39I, GLU54I, GLY33J, GLY74I, GLY94J, HIS117J, HIS123J, ILE120J, ILE138I, ILE146I, ILE189J, ILE190J, ILE29J, ILE30I, ILE30J, ILE40I, ILE48I, ILE64J, ILE71I, ILE77I, LEU115J, LEU121J, LEU153I, LEU16J, LEU24I, LEU24J, LEU25I, LEU25J, LEU32J, LEU44I, LEU49I, LEU50I, LEU51I, LEU62J, LEU83I, LYS147I, MET122J, MET150I, MET75I, MET81I, MET93J, MET95J, PHE102I, PHE143I, PHE157I, PHE175J, PHE31I, PHE31J, PRO116J, PRO67J, PRO85I, SER15I, SER15J, SER19I, SER19J, SER26I, SER26J, SER34J, SER61J, SER66J, SER70I, SER72I, THR176J, THR17I, THR17J, THR191J, THR80I, TRP174J, TYR113J, TYR21I, TYR21J, TYR63J, TYR78I, TYR91J, VAL145I, VAL20I, VAL20J, VAL82I
• J-K: ALA114K, ALA118K, ALA137J, ALA140J, ALA144J, ALA177K, ALA41J, ALA46J, ALA52J, ALA53J, ALA73J, ALA76J, ALA84J, ALA92K, ALA97K, ARG119K, ARG152J, ARG171K, ARG173K, ARG23J, ARG23K, ARG28J, ARG43J, ASN37J, ASN42J, ASN65K, ASP172K, ASP18J, ASP18K, ASP38J, ASP79J, CYS45J, GLN139J, GLN142J, GLN47J, GLU141J, GLU149J, GLU179K, GLU22J, GLU22K, GLU27K, GLU39J, GLU54J, GLY33K, GLY94K, HIS117K, ILE120K, ILE136J, ILE138J, ILE146J, ILE190K, ILE29K, ILE30J, ILE30K, ILE40J, ILE48J, ILE64K, ILE71J, ILE77J, LEU115K, LEU121K, LEU153J, LEU16K, LEU24J, LEU24K, LEU25J, LEU25K, LEU32K, LEU44J, LEU49J, LEU50J, LEU51J, LEU83J, MET122K, MET150J, MET75J, MET81J, MET93K, MET95K, PHE102J, PHE143J, PHE157J, PHE175K, PHE31J, PHE31K, PRO116K, PRO67K, PRO85J, SER15J, SER15K, SER19J, SER19K, SER26J, SER26K, SER34K, SER61K, SER66K, SER70J, SER72J, THR176K, THR17J, THR17K, THR191K, THR80J, TRP174K, TYR113K, TYR21J, TYR21K, TYR63K, TYR78J, TYR91K, VAL145J, VAL20J, VAL20K, VAL82J
• K-L: ALA114L, ALA118L, ALA137K, ALA140K, ALA144K, ALA177L, ALA193L, ALA41K, ALA46K, ALA52K, ALA53K, ALA56K, ALA73K, ALA76K, ALA84K, ALA92L, ALA97L, ARG119L, ARG152K, ARG171L, ARG173L, ARG192L, ARG23K, ARG23L, ARG28K, ARG43K, ASN37K, ASN42K, ASN65L, ASP172L, ASP18K, ASP18L, ASP38K, ASP79K, ASP87K, CYS45K, CYS86K, GLN139K, GLN142K, GLN47K, GLU141K, GLU149K, GLU179L, GLU22K, GLU22L, GLU27K, GLU27L, GLU35L, GLU39K, GLU54K, GLY33L, GLY94L, HIS117L, ILE120L, ILE136K, ILE138K, ILE146K, ILE190L, ILE29L, ILE30K, ILE30L, ILE40K, ILE48K, ILE64L, ILE71K, ILE77K, LEU115L, LEU121L, LEU153K, LEU16L, LEU24K, LEU24L, LEU25K, LEU25L, LEU32L, LEU44K, LEU49K, LEU50K, LEU51K, LEU83K, MET122L, MET150K, MET75K, MET81K, MET93L, MET95L, PHE102K, PHE143K, PHE157K, PHE175L, PHE31K, PHE31L, PRO116L, PRO67L, PRO85K, SER15K, SER15L, SER19K, SER19L, SER26K, SER26L, SER34L, SER57K, SER61L, SER66L, SER70K, SER72K, THR176L, THR17K, THR17L, THR191L, THR80K, TRP174L, TYR113L, TYR21K, TYR21L, TYR63L, TYR78K, TYR91L, VAL145K, VAL20K, VAL20L, VAL82K
• L-M: ALA114M, ALA118M, ALA137L, ALA140L, ALA144L, ALA177M, ALA41L, ALA46L, ALA52L, ALA53L, ALA73L, ALA76L, ALA84L, ALA92M, ALA97M, ARG119M, ARG152L, ARG171M, ARG173M, ARG23L, ARG23M, ARG28L, ARG28M, ARG43L, ASN42L, ASN65M, ASP172M, ASP18L, ASP18M, ASP38L, ASP79L, CYS45L, GLN139L, GLN142L, GLN47L, GLU141L, GLU149L, GLU179M, GLU22L, GLU22M, GLU27M, GLU39L, GLU54L, GLY33M, GLY94M, HIS117M, HIS123M, ILE120M, ILE136L, ILE138L, ILE146L, ILE190M, ILE29M, ILE30L, ILE30M, ILE40L, ILE48L, ILE64M, ILE71L, ILE77L, LEU115M, LEU121M, LEU153L, LEU16M, LEU24L, LEU24M, LEU25L, LEU25M, LEU32M, LEU44L, LEU49L, LEU50L, LEU51L, LEU83L, LYS148L, MET122M, MET150L, MET75L, MET81L, MET93M, MET95M, PHE102L, PHE143L, PHE157L, PHE175M, PHE31L, PHE31M, PRO116M, PRO67M, PRO85L, SER15L, SER15M, SER19L, SER19M, SER26L, SER26M, SER34M, SER61M, SER66M, SER70L, SER72L, THR176M, THR17L, THR17M, THR191M, THR80L, TRP174M, TYR113M, TYR21L, TYR21M, TYR63M, TYR78L, TYR91M, VAL145L, VAL20L, VAL20M, VAL82L
• M-N: ALA114N, ALA118N, ALA140M, ALA144M, ALA177N, ALA41M, ALA46M, ALA52M, ALA53M, ALA73M, ALA76M, ALA84M, ALA92N, ALA97N, ARG119N, ARG152M, ARG171N, ARG173N, ARG23M, ARG23N, ARG28M, ARG43M, ASN42M, ASN65N, ASP172N, ASP18M, ASP18N, ASP38M, ASP79M, CYS45M, GLN139M, GLN142M, GLN47M, GLU141M, GLU149M, GLU179N, GLU22M, GLU22N, GLU27M, GLU27N, GLU39M, GLU54M, GLY33N, GLY94N, HIS117N, ILE120N, ILE136M, ILE138M, ILE146M, ILE189N, ILE190N, ILE29N, ILE30M, ILE30N, ILE40M, ILE48M, ILE64N, ILE71M, ILE77M, LEU115N, LEU121N, LEU153M, LEU16N, LEU24M, LEU24N, LEU25M, LEU25N, LEU32N, LEU44M, LEU49M, LEU50M, LEU51M, LEU83M, MET150M, MET75M, MET81M, MET93N, MET95N, PHE102M, PHE143M, PHE157M, PHE175N, PHE31M, PHE31N, PRO116N, PRO67N, PRO85M, SER15M, SER15N, SER19M, SER19N, SER26M, SER26N, SER34N, SER61N, SER66N, SER70M, SER72M, THR176N, THR17M, THR17N, THR191N, THR80M, TRP174N, TYR113N, TYR21M, TYR21N, TYR63N, TYR78M, TYR91N, VAL145M, VAL20M, VAL20N, VAL82M