2CB4

crystal structure of the catalytic domain of the mosquitocidal toxin from bacillus sphaericus, mutant e197q

• Total interactions analyzed: 91
• Total true interactions: 28
• Strongest Interaction:
  • Chains: G-I
  • Int. Res.: 69
  • Norm. En. per Res.: -2.8621
• Hub Node: A(4)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	0.0	-0.5725	-134.731	-135.3035	83	3	0	5636	2	17	18
A-G	-3.0972	-5.4009	-142.138	-150.636	82	5	0	5728	2	18	18
A-H	-36.2481	7.8293	-165.095	-193.5138	68	4	1	6326	0	12	12
A-I	0.0	0.0	-4.4494	-4.4494	11	1	0	228	0	4	4
B-C	0.0	-5.7327	-135.535	-141.2677	83	3	0	5686	1	18	18
B-H	0.0	0.0	-4.6416	-4.6416	10	1	0	218	0	4	4
B-N	-31.2102	7.7441	-153.771	-177.2371	67	2	1	6194	0	12	12
C-D	0.0	-5.0837	-126.708	-131.7917	79	3	0	5434	2	17	18
C-M	-38.9646	8.089	-163.655	-194.5306	68	2	1	6237	0	12	12
C-N	0.0	0.0	-4.9289	-4.9289	11	0	0	211	0	4	4
D-E	0.0	-3.2526	-133.071	-136.3236	84	1	0	5604	2	17	18
D-L	-42.1663	7.9757	-162.642	-196.8326	69	4	1	6407	0	12	12
D-M	0.0	0.0	-5.7119	-5.7119	11	0	0	231	0	4	4
E-F	0.0	-3.6806	-131.885	-135.5656	82	2	0	5584	2	17	18
E-K	-32.5518	7.7172	-159.303	-184.1375	68	3	1	6218	0	12	12
E-L	0.0	0.0	-4.9369	-4.9369	10	0	0	211	0	4	4
F-G	0.0	-3.4691	-134.03	-137.4991	82	3	0	5644	1	17	17
F-J	-41.6351	7.8127	-158.95	-192.7724	68	2	1	6198	0	12	12
F-K	0.0	0.0	-4.5049	-4.5049	10	0	0	196	0	4	4
G-I	-36.5233	6.8631	-167.826	-197.4862	69	4	1	6500	0	12	12
G-J	0.0	0.0	-4.6533	-4.6533	11	1	0	224	0	4	4
H-I	0.0	-3.321	-138.777	-142.098	83	3	0	5653	2	18	18
H-N	0.0	-3.6709	-128.356	-132.0269	83	2	0	5493	1	17	18
I-J	0.0	0.505	-144.572	-144.067	83	3	0	5823	2	17	17
J-K	0.0	-4.4953	-137.934	-142.4293	81	2	0	5644	2	17	18
K-L	0.0	-3.8009	-136.577	-140.3779	84	2	0	5628	2	17	18
L-M	0.0	-4.2874	-127.448	-131.7354	84	3	0	5453	2	17	17
M-N	0.0	-3.022	-124.564	-127.586	82	2	0	5362	1	17	17

Interface residues

• A-B: ALA163A, ALA278A, ALA43B, ALA44B, ARG100A, ARG114A, ARG133A, ARG205B, ARG63A, ASN109B, ASN130A, ASN135A, ASN164A, ASN165A, ASN166A, ASN188A, ASN194A, ASN226B, ASN228B, ASN231B, ASN252B, ASN271A, ASN280A, ASN38B, ASN83B, ASP125A, ASP260A, ASP275A, ASP51B, GLN118B, GLN272A, GLN42B, GLN86B, GLU124A, GLU207B, GLU251B, GLU282A, GLY110B, GLY281A, GLY85B, HIS127A, HIS161A, HIS250B, HIS253B, ILE106B, ILE230B, ILE80B, ILE87B, LEU108B, LEU129A, LEU235B, LEU46B, LEU49B, PHE107B, PHE192A, PHE208B, PHE229B, PHE248B, PHE274A, PHE277A, PRO122A, PRO137A, PRO160A, PRO176B, PRO191A, PRO206B, PRO227B, PRO232B, PRO279A, SER136A, SER138A, SER162A, SER254B, SER261A, SER45B, THR134A, THR47B, THR84B, TRP249B, TRP48B, TYR131A, TYR270A, VAL123A
• A-G: ALA163G, ALA278G, ALA43A, ALA44A, ARG100G, ARG114G, ARG133G, ARG205A, ARG63G, ASN109A, ASN130G, ASN135G, ASN164G, ASN165G, ASN166G, ASN188G, ASN194G, ASN226A, ASN228A, ASN231A, ASN252A, ASN271G, ASN280G, ASN38A, ASP125G, ASP260G, ASP275G, ASP51A, GLN118A, GLN272G, GLN42A, GLN86A, GLU124G, GLU207A, GLU251A, GLU282G, GLY110A, GLY281G, GLY85A, HIS127G, HIS161G, HIS250A, HIS253A, ILE106A, ILE230A, ILE80A, ILE87A, LEU108A, LEU129G, LEU235A, LEU46A, LEU49A, PHE107A, PHE192G, PHE208A, PHE229A, PHE248A, PHE274G, PHE277G, PRO122G, PRO137G, PRO160G, PRO176A, PRO191G, PRO206A, PRO227A, PRO232A, PRO279G, PRO65G, SER136G, SER162G, SER254A, SER261G, SER45A, THR134G, THR47A, THR84A, TRP249A, TRP48A, TYR131G, TYR270G, VAL123G
• A-H: ARG222A, ARG222H, ASN164A, ASN164H, ASN165A, ASN165H, ASN166A, ASN166H, ASN217A, ASN217H, ASN243A, ASN243H, ASN258A, ASN258H, ASN285A, ASN285H, ASN291A, ASN291H, ASN292A, ASN292H, ASN295A, ASN295H, GLN298A, GLN298H, GLU214A, GLU214H, GLU219A, GLU219H, GLU255A, GLU255H, GLY218A, GLY218H, HIS216A, HIS216H, ILE167A, ILE167H, ILE220A, ILE220H, ILE223A, ILE223H, ILE244A, ILE244H, ILE297A, ILE297H, LEU294A, LEU294H, LYS246A, LYS246H, PRO241A, PRO241H, SER242A, SER242H, SER245A, SER245H, SER254A, SER254H, SER293A, SER293H, TRP224A, TRP224H, TYR215A, TYR215H, VAL221A, VAL221H, VAL247A, VAL247H, VAL296A, VAL296H
• A-I: ARG222A, ARG222I, ASN252A, GLU255A, GLU255I, HIS250A, HIS250I, HIS253A, HIS253I, SER254A, SER254I
• B-C: ALA163B, ALA278B, ALA43C, ALA44C, ARG100B, ARG114B, ARG133B, ARG205C, ARG63B, ASN109C, ASN130B, ASN135B, ASN164B, ASN165B, ASN166B, ASN188B, ASN190B, ASN194B, ASN226C, ASN228C, ASN231C, ASN252C, ASN271B, ASN280B, ASN38C, ASP125B, ASP260B, ASP275B, ASP51C, GLN118C, GLN272B, GLN42C, GLN86C, GLU124B, GLU207C, GLU251C, GLU282B, GLY110C, GLY281B, GLY85C, HIS127B, HIS161B, HIS250C, HIS253C, ILE106C, ILE230C, ILE80C, LEU108C, LEU129B, LEU235C, LEU46C, LEU49C, PHE107C, PHE192B, PHE208C, PHE229C, PHE248C, PHE274B, PHE277B, PRO122B, PRO137B, PRO160B, PRO176C, PRO191B, PRO193B, PRO206C, PRO227C, PRO232C, PRO279B, PRO65B, SER136B, SER162B, SER254C, SER261B, SER45C, THR134B, THR47C, THR84C, TRP249C, TRP48C, TYR131B, TYR270B, VAL123B
• B-H: ARG222B, ARG222H, GLU255B, GLU255H, HIS250B, HIS250H, HIS253B, HIS253H, SER254B, SER254H
• B-N: ARG222B, ARG222N, ASN164B, ASN164N, ASN165B, ASN165N, ASN166B, ASN166N, ASN217B, ASN217N, ASN243B, ASN243N, ASN258B, ASN258N, ASN285B, ASN285N, ASN291B, ASN291N, ASN292B, ASN292N, ASN295B, ASN295N, GLN298B, GLN298N, GLU214B, GLU214N, GLU219B, GLU219N, GLU255B, GLU255N, GLY218B, GLY218N, HIS216B, HIS216N, ILE167B, ILE167N, ILE220B, ILE220N, ILE223N, ILE244B, ILE244N, ILE297B, ILE297N, LEU294B, LEU294N, LYS246B, LYS246N, PRO241B, PRO241N, SER242B, SER242N, SER245B, SER245N, SER254B, SER254N, SER293B, SER293N, TRP224B, TRP224N, TYR215B, TYR215N, VAL221B, VAL221N, VAL247B, VAL247N, VAL296B, VAL296N
• C-D: ALA163C, ALA278C, ALA43D, ALA44D, ARG100C, ARG114C, ARG133C, ARG205D, ARG63C, ASN109D, ASN130C, ASN135C, ASN165C, ASN166C, ASN194C, ASN226D, ASN228D, ASN231D, ASN252D, ASN271C, ASN280C, ASN38D, ASP125C, ASP260C, ASP275C, ASP51D, GLN118D, GLN272C, GLN42D, GLN86D, GLU124C, GLU207D, GLU251D, GLU282C, GLY110D, GLY281C, GLY85D, HIS127C, HIS161C, HIS250D, HIS253D, ILE106D, ILE230D, ILE80D, ILE87D, LEU108D, LEU129C, LEU235D, LEU46D, LEU49D, PHE107D, PHE192C, PHE208D, PHE229D, PHE248D, PHE274C, PHE277C, PRO122C, PRO137C, PRO160C, PRO176D, PRO191C, PRO206D, PRO227D, PRO232D, PRO279C, PRO65C, SER136C, SER162C, SER254D, SER261C, SER45D, THR134C, THR47D, TRP249D, TRP48D, TYR131C, TYR270C, VAL123C
• C-M: ARG222C, ARG222M, ASN164C, ASN164M, ASN165C, ASN165M, ASN166C, ASN166M, ASN217C, ASN217M, ASN243C, ASN243M, ASN258C, ASN258M, ASN285C, ASN285M, ASN291C, ASN291M, ASN292C, ASN292M, ASN295C, ASN295M, GLN298C, GLN298M, GLU214C, GLU214M, GLU219C, GLU219M, GLU255C, GLU255M, GLY218C, GLY218M, HIS216C, HIS216M, ILE167C, ILE167M, ILE220C, ILE220M, ILE223C, ILE223M, ILE244C, ILE244M, ILE297C, ILE297M, LEU294C, LEU294M, LYS246C, LYS246M, PRO241C, PRO241M, SER242C, SER242M, SER245C, SER245M, SER254C, SER254M, SER293C, SER293M, TRP224C, TRP224M, TYR215C, TYR215M, VAL221C, VAL221M, VAL247C, VAL247M, VAL296C, VAL296M
• C-N: ARG222C, ARG222N, ASN252N, GLU255C, GLU255N, HIS250C, HIS250N, HIS253C, HIS253N, SER254C, SER254N
• D-E: ALA163D, ALA278D, ALA43E, ALA44E, ARG100D, ARG114D, ARG133D, ARG205E, ARG63D, ASN109E, ASN130D, ASN135D, ASN164D, ASN165D, ASN166D, ASN188D, ASN194D, ASN226E, ASN228E, ASN231E, ASN252E, ASN271D, ASN280D, ASN38E, ASN83E, ASP125D, ASP260D, ASP275D, ASP51E, GLN118E, GLN272D, GLN42E, GLN86E, GLU124D, GLU207E, GLU251E, GLU282D, GLY110E, GLY281D, GLY85E, HIS127D, HIS161D, HIS250E, HIS253E, ILE106E, ILE230E, ILE80E, ILE87E, LEU108E, LEU129D, LEU235E, LEU46E, LEU49E, PHE107E, PHE192D, PHE208E, PHE229E, PHE248E, PHE274D, PHE277D, PRO122D, PRO137D, PRO160D, PRO176E, PRO191D, PRO193D, PRO206E, PRO227E, PRO232E, PRO279D, PRO65D, SER136D, SER162D, SER254E, SER261D, SER45E, THR134D, THR47E, THR84E, TRP249E, TRP48E, TYR131D, TYR270D, VAL123D
• D-L: ARG222D, ARG222L, ASN164D, ASN164L, ASN165D, ASN165L, ASN166D, ASN166L, ASN217D, ASN217L, ASN243D, ASN243L, ASN258D, ASN258L, ASN285D, ASN285L, ASN287D, ASN291D, ASN291L, ASN292D, ASN292L, ASN295D, ASN295L, GLN298D, GLN298L, GLU214D, GLU214L, GLU219D, GLU219L, GLU255D, GLU255L, GLY218D, GLY218L, HIS216D, HIS216L, ILE167D, ILE167L, ILE220D, ILE220L, ILE223D, ILE223L, ILE244D, ILE244L, ILE297D, ILE297L, LEU294D, LEU294L, LYS246D, LYS246L, PRO241D, PRO241L, SER242D, SER242L, SER245D, SER245L, SER254D, SER254L, SER293D, SER293L, TRP224D, TRP224L, TYR215D, TYR215L, VAL221D, VAL221L, VAL247D, VAL247L, VAL296D, VAL296L
• D-M: ARG222D, ARG222M, ASN252M, GLU255D, GLU255M, HIS250D, HIS250M, HIS253D, HIS253M, SER254D, SER254M
• E-F: ALA163E, ALA278E, ALA43F, ALA44F, ARG100E, ARG114E, ARG133E, ARG205F, ARG63E, ASN109F, ASN130E, ASN135E, ASN164E, ASN165E, ASN166E, ASN188E, ASN194E, ASN226F, ASN228F, ASN231F, ASN252F, ASN271E, ASN280E, ASN38F, ASN83F, ASP125E, ASP260E, ASP275E, ASP51F, GLN118F, GLN272E, GLN42F, GLN86F, GLU124E, GLU207F, GLU251F, GLU282E, GLY110F, GLY281E, GLY85F, HIS127E, HIS161E, HIS250F, HIS253F, ILE106F, ILE230F, ILE80F, ILE87F, LEU108F, LEU129E, LEU235F, LEU46F, LEU49F, PHE107F, PHE192E, PHE208F, PHE229F, PHE248F, PHE274E, PHE277E, PRO122E, PRO137E, PRO160E, PRO176F, PRO191E, PRO206F, PRO227F, PRO232F, PRO279E, SER136E, SER162E, SER254F, SER261E, SER45F, THR134E, THR47F, THR84F, TRP249F, TRP48F, TYR131E, TYR270E, VAL123E
• E-K: ARG222E, ARG222K, ASN164E, ASN164K, ASN165E, ASN165K, ASN166E, ASN166K, ASN217E, ASN217K, ASN243E, ASN243K, ASN258E, ASN258K, ASN285E, ASN285K, ASN291E, ASN291K, ASN292E, ASN292K, ASN295E, ASN295K, GLN298E, GLN298K, GLU214E, GLU214K, GLU219E, GLU219K, GLU255E, GLU255K, GLY218E, GLY218K, HIS216E, HIS216K, ILE167E, ILE167K, ILE220E, ILE220K, ILE223E, ILE223K, ILE244E, ILE244K, ILE297E, ILE297K, LEU294E, LEU294K, LYS246E, LYS246K, PRO241E, PRO241K, SER242E, SER242K, SER245E, SER245K, SER254E, SER254K, SER293E, SER293K, TRP224E, TRP224K, TYR215E, TYR215K, VAL221E, VAL221K, VAL247E, VAL247K, VAL296E, VAL296K
• E-L: ARG222E, ARG222L, GLU255E, GLU255L, HIS250E, HIS250L, HIS253E, HIS253L, SER254E, SER254L
• F-G: ALA163F, ALA278F, ALA43G, ALA44G, ARG100F, ARG114F, ARG133F, ARG205G, ARG63F, ASN109G, ASN130F, ASN135F, ASN164F, ASN165F, ASN166F, ASN188F, ASN194F, ASN226G, ASN228G, ASN231G, ASN252G, ASN271F, ASN280F, ASN38G, ASN83G, ASP125F, ASP260F, ASP275F, ASP51G, GLN118G, GLN272F, GLN42G, GLN86G, GLU124F, GLU207G, GLU251G, GLU282F, GLY110G, GLY281F, GLY85G, HIS127F, HIS161F, HIS250G, HIS253G, ILE106G, ILE230G, ILE80G, ILE87G, LEU108G, LEU129F, LEU235G, LEU46G, LEU49G, PHE107G, PHE192F, PHE208G, PHE229G, PHE248G, PHE274F, PHE277F, PRO122F, PRO137F, PRO160F, PRO176G, PRO191F, PRO206G, PRO227G, PRO232G, PRO279F, SER136F, SER162F, SER254G, SER261F, SER45G, THR134F, THR47G, THR84G, TRP249G, TRP48G, TYR131F, TYR270F, VAL123F
• F-J: ARG222F, ARG222J, ASN164F, ASN164J, ASN165F, ASN165J, ASN166F, ASN166J, ASN217F, ASN217J, ASN243F, ASN243J, ASN258F, ASN258J, ASN285F, ASN285J, ASN291F, ASN291J, ASN292F, ASN292J, ASN295F, ASN295J, GLN298F, GLN298J, GLU214F, GLU214J, GLU219F, GLU219J, GLU255F, GLU255J, GLY218F, GLY218J, HIS216F, HIS216J, ILE167F, ILE167J, ILE220F, ILE220J, ILE223F, ILE223J, ILE244F, ILE244J, ILE297F, ILE297J, LEU294F, LEU294J, LYS246F, LYS246J, PRO241F, PRO241J, SER242F, SER242J, SER245F, SER245J, SER254F, SER254J, SER293F, SER293J, TRP224F, TRP224J, TYR215F, TYR215J, VAL221F, VAL221J, VAL247F, VAL247J, VAL296F, VAL296J
• F-K: ARG222F, ARG222K, GLU255F, GLU255K, HIS250F, HIS250K, HIS253F, HIS253K, SER254F, SER254K
• G-I: ARG222G, ARG222I, ASN164G, ASN164I, ASN165G, ASN165I, ASN166G, ASN166I, ASN217G, ASN217I, ASN243G, ASN243I, ASN258G, ASN258I, ASN285G, ASN285I, ASN287I, ASN291G, ASN291I, ASN292G, ASN292I, ASN295G, ASN295I, GLN298G, GLN298I, GLU214G, GLU214I, GLU219G, GLU219I, GLU255G, GLU255I, GLY218G, GLY218I, HIS216G, HIS216I, ILE167G, ILE167I, ILE220G, ILE220I, ILE223G, ILE223I, ILE244G, ILE244I, ILE297G, ILE297I, LEU294G, LEU294I, LYS246G, LYS246I, PRO241G, PRO241I, SER242G, SER242I, SER245G, SER245I, SER254G, SER254I, SER293G, SER293I, TRP224G, TRP224I, TYR215G, TYR215I, VAL221G, VAL221I, VAL247G, VAL247I, VAL296G, VAL296I
• G-J: ARG222G, ARG222J, ASN252G, GLU255G, GLU255J, HIS250G, HIS250J, HIS253G, HIS253J, SER254G, SER254J
• H-I: ALA163H, ALA278H, ALA43I, ALA44I, ARG100H, ARG114H, ARG133H, ARG205I, ARG63H, ASN109I, ASN130H, ASN135H, ASN164H, ASN165H, ASN166H, ASN188H, ASN194H, ASN226I, ASN228I, ASN231I, ASN252I, ASN271H, ASN280H, ASN38I, ASP125H, ASP260H, ASP273H, ASP275H, ASP51I, GLN118I, GLN272H, GLN42I, GLN86I, GLU124H, GLU207I, GLU251I, GLU282H, GLY110I, GLY281H, GLY85I, HIS127H, HIS161H, HIS250I, HIS253I, ILE106I, ILE230I, ILE80I, ILE87I, LEU108I, LEU129H, LEU235I, LEU46I, LEU49I, PHE107I, PHE192H, PHE208I, PHE229I, PHE248I, PHE274H, PHE277H, PRO122H, PRO137H, PRO160H, PRO176I, PRO191H, PRO206I, PRO227I, PRO232I, PRO279H, PRO65H, SER136H, SER162H, SER254I, SER261H, SER45I, THR134H, THR47I, THR84I, TRP249I, TRP48I, TYR131H, TYR270H, VAL123H
• H-N: ALA163N, ALA278N, ALA43H, ALA44H, ARG100N, ARG114N, ARG133N, ARG205H, ARG63N, ASN109H, ASN130N, ASN135N, ASN164N, ASN165N, ASN166N, ASN188N, ASN194N, ASN226H, ASN228H, ASN231H, ASN252H, ASN271N, ASN280N, ASN38H, ASN83H, ASP125N, ASP260N, ASP275N, ASP51H, GLN118H, GLN272N, GLN42H, GLN86H, GLU124N, GLU207H, GLU251H, GLU282N, GLY110H, GLY281N, GLY85H, HIS127N, HIS161N, HIS250H, HIS253H, ILE106H, ILE230H, ILE80H, ILE87H, LEU108H, LEU129N, LEU235H, LEU46H, LEU49H, PHE107H, PHE192N, PHE208H, PHE229H, PHE248H, PHE274N, PHE277N, PRO122N, PRO137N, PRO160N, PRO176H, PRO191N, PRO193N, PRO206H, PRO227H, PRO232H, PRO279N, SER136N, SER162N, SER254H, SER261N, SER45H, THR134N, THR47H, THR84H, TRP249H, TRP48H, TYR131N, TYR270N, VAL123N
• I-J: ALA163I, ALA278I, ALA43J, ALA44J, ARG100I, ARG133I, ARG205J, ARG63I, ASN109J, ASN130I, ASN135I, ASN164I, ASN165I, ASN166I, ASN188I, ASN194I, ASN226J, ASN228J, ASN231J, ASN252J, ASN271I, ASN280I, ASN38J, ASN83J, ASP125I, ASP260I, ASP275I, ASP51J, GLN118J, GLN272I, GLN42J, GLN86J, GLU124I, GLU207J, GLU251J, GLU282I, GLY110J, GLY281I, GLY85J, HIS127I, HIS161I, HIS250J, HIS253J, ILE106J, ILE230J, ILE80J, ILE87J, LEU108J, LEU129I, LEU235J, LEU46J, LEU49J, PHE107J, PHE192I, PHE208J, PHE229J, PHE248J, PHE274I, PHE277I, PRO122I, PRO137I, PRO160I, PRO176J, PRO191I, PRO193I, PRO206J, PRO227J, PRO232J, PRO279I, SER136I, SER162I, SER254J, SER261I, SER45J, SER82J, THR134I, THR47J, THR84J, TRP249J, TRP48J, TYR131I, TYR270I, VAL123I
• J-K: ALA163J, ALA278J, ALA43K, ALA44K, ARG100J, ARG114J, ARG133J, ARG205K, ARG63J, ASN109K, ASN130J, ASN135J, ASN164J, ASN165J, ASN166J, ASN188J, ASN194J, ASN226K, ASN228K, ASN231K, ASN252K, ASN271J, ASN280J, ASN38K, ASP125J, ASP260J, ASP275J, ASP51K, GLN118K, GLN272J, GLN42K, GLN86K, GLU124J, GLU207K, GLU251K, GLU282J, GLY110K, GLY281J, GLY85K, HIS127J, HIS161J, HIS250K, HIS253K, ILE106K, ILE230K, ILE87K, LEU108K, LEU129J, LEU235K, LEU46K, LEU49K, PHE107K, PHE192J, PHE208K, PHE229K, PHE248K, PHE274J, PHE277J, PRO122J, PRO137J, PRO160J, PRO176K, PRO191J, PRO206K, PRO227K, PRO232K, PRO279J, PRO65J, SER136J, SER162J, SER254K, SER261J, SER45K, THR134J, THR47K, THR84K, TRP249K, TRP48K, TYR131J, TYR270J, VAL123J
• K-L: ALA163K, ALA278K, ALA43L, ALA44L, ARG100K, ARG114K, ARG133K, ARG205L, ARG63K, ASN109L, ASN130K, ASN135K, ASN164K, ASN165K, ASN166K, ASN188K, ASN194K, ASN226L, ASN228L, ASN231L, ASN252L, ASN271K, ASN280K, ASN38L, ASN83L, ASP125K, ASP260K, ASP275K, ASP51L, GLN118L, GLN272K, GLN42L, GLN86L, GLU124K, GLU207L, GLU251L, GLU282K, GLY110L, GLY281K, GLY85L, HIS127K, HIS161K, HIS250L, HIS253L, ILE106L, ILE230L, ILE80L, ILE87L, LEU108L, LEU129K, LEU235L, LEU46L, LEU49L, PHE107L, PHE192K, PHE208L, PHE229L, PHE248L, PHE274K, PHE277K, PRO122K, PRO137K, PRO160K, PRO176L, PRO191K, PRO206L, PRO227L, PRO232L, PRO279K, PRO65K, SER136K, SER162K, SER254L, SER261K, SER45L, SER82L, THR134K, THR47L, THR84L, TRP249L, TRP48L, TYR131K, TYR270K, VAL123K
• L-M: ALA163L, ALA278L, ALA43M, ALA44M, ARG100L, ARG114L, ARG133L, ARG205M, ARG63L, ASN109M, ASN130L, ASN135L, ASN164L, ASN165L, ASN166L, ASN188L, ASN194L, ASN226M, ASN228M, ASN231M, ASN252M, ASN271L, ASN280L, ASN38M, ASN83M, ASP125L, ASP260L, ASP275L, ASP51M, GLN118M, GLN272L, GLN42M, GLN86M, GLU124L, GLU207M, GLU251M, GLU282L, GLY110M, GLY281L, GLY85M, HIS127L, HIS161L, HIS250M, HIS253M, ILE106M, ILE230M, ILE87M, LEU108M, LEU129L, LEU235M, LEU46M, LEU49M, PHE107M, PHE192L, PHE208M, PHE229M, PHE248M, PHE274L, PHE277L, PRO122L, PRO137L, PRO160L, PRO176M, PRO191L, PRO193L, PRO206M, PRO227M, PRO232M, PRO279L, PRO65L, SER136L, SER162L, SER254M, SER261L, SER45M, SER82M, THR134L, THR47M, THR84M, TRP249M, TRP48M, TYR131L, TYR270L, VAL123L
• M-N: ALA163M, ALA278M, ALA43N, ALA44N, ARG100M, ARG114M, ARG133M, ARG205N, ARG63M, ASN109N, ASN130M, ASN135M, ASN164M, ASN165M, ASN166M, ASN188M, ASN194M, ASN226N, ASN228N, ASN231N, ASN252N, ASN271M, ASN280M, ASN38N, ASN83N, ASP260M, ASP275M, ASP51N, GLN118N, GLN272M, GLN42N, GLN86N, GLU124M, GLU207N, GLU251N, GLU282M, GLY110N, GLY281M, GLY85N, HIS127M, HIS161M, HIS250N, HIS253N, ILE106N, ILE230N, ILE87N, LEU108N, LEU129M, LEU235N, LEU46N, LEU49N, PHE107N, PHE192M, PHE208N, PHE229N, PHE248N, PHE274M, PHE277M, PRO122M, PRO137M, PRO160M, PRO176N, PRO191M, PRO193M, PRO206N, PRO227N, PRO232N, PRO279M, PRO65M, SER136M, SER162M, SER254N, SER261M, SER45N, THR134M, THR47N, THR84N, TRP249N, TRP48N, TYR131M, TYR270M, VAL123M