2C9T

crystal structure of acetylcholine binding protein (achbp) from aplysia californica in complex with alpha-conotoxin imi

• Total interactions analyzed: 153
• Total true interactions: 36
• Strongest Interaction:
  • Chains: F-P
  • Int. Res.: 45
  • Norm. En. per Res.: -4.5682
• Hub Node: A(6)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-43.477	-49.9093	-320.544	-413.9302	125	17	2	12677	5	26	20
A-E	-27.2567	-11.8514	-291.496	-330.6041	118	11	2	11920	1	23	20
A-H	0.0	0.0	-1.1706	-1.1706	6	0	0	192	0	0	2
A-I	-10.8191	-21.324	-69.3199	-101.4629	35	5	0	2750	3	12	15
A-K	-15.8489	-47.9267	-137.744	-201.5196	45	3	0	4398	3	9	9
A-O	-4.4771	-6.3336	-73.1835	-83.9942	45	1	1	3178	0	6	6
B-C	-43.2474	-13.2126	-306.111	-362.571	127	19	2	12651	1	24	20
B-G	0.0	0.0	-0.6597	-0.6597	6	0	0	143	0	0	2
B-H	0.0	-22.0677	-69.6721	-91.7398	35	8	0	2801	4	12	16
B-K	0.0	-8.7004	-68.7887	-77.4891	44	2	1	3062	0	5	7
C-D	-31.8036	-14.5139	-316.516	-362.8335	123	10	2	12345	1	25	20
C-F	0.0	0.0	-0.3575	-0.3575	6	0	0	105	0	0	1
C-G	-7.8181	-17.0648	-61.1697	-86.0525	31	4	0	2528	4	12	15
C-M	-15.3319	-38.1953	-134.343	-187.8703	45	8	0	4510	0	9	9
D-E	-54.5071	-11.0354	-329.341	-394.8836	135	13	2	13005	3	24	21
D-F	0.0	-20.8536	-64.0883	-84.9419	31	5	0	2579	4	12	15
D-J	0.0	0.0	-0.6276	-0.6276	6	0	0	142	0	0	2
D-M	0.0	-10.3655	-74.4767	-84.8422	41	2	1	3152	0	6	6
E-I	0.0	0.0	-1.0338	-1.0338	7	0	0	181	0	0	2
E-J	0.0	-15.7198	-63.8362	-79.556	37	6	0	2728	4	12	15
E-O	-8.1924	-49.7293	-141.795	-199.7167	45	3	0	4568	3	9	9
F-G	-33.2272	-25.74	-317.604	-376.5712	123	11	2	12566	3	25	20
F-J	-37.0907	-12.745	-310.025	-359.8607	127	8	2	12351	3	25	20
F-P	-13.9413	-48.749	-142.879	-205.5693	45	2	0	4464	2	9	9
F-T	-8.4715	-8.4215	-66.268	-83.161	40	4	1	3111	0	5	6
G-H	-35.9156	-27.8635	-316.246	-380.0251	120	7	2	12519	2	25	20
G-P	-5.87	-8.969	-87.7869	-102.6259	42	2	1	3368	0	5	6
G-Q	-14.9777	-37.3054	-132.656	-184.9391	45	7	0	4597	1	9	9
H-I	-38.1004	-2.4985	-310.012	-350.6109	129	11	2	12496	2	25	20
H-Q	-13.6409	-11.3967	-74.4785	-99.516	46	6	1	3183	0	7	7
H-R	-15.3493	-31.0752	-131.651	-178.0755	44	7	0	4352	0	9	9
I-J	-42.2329	-1.3346	-313.655	-357.2225	125	11	2	12328	1	24	20
I-R	-13.3328	-12.1904	-70.3592	-95.8824	42	6	1	3075	0	7	6
I-S	-3.2327	-38.0941	-138.708	-180.0348	44	4	0	4400	2	9	9
J-S	0.0	-6.3945	-77.0801	-83.4746	41	2	1	3176	0	6	7
J-T	-9.2499	-53.0882	-136.443	-198.7811	44	3	0	4388	4	9	9

Interface residues

• A-B: ALA105B, ALA118B, ALA139A, ALA168B, ALA2B, ALA90A, ARG120B, ARG205B, ARG6B, ARG77B, ARG95A, ARG95B, ASN13B, ASN3B, ASN46A, ASN61A, ASN72B, ASP126A, ASP24A, ASP25A, ASP37B, ASP42A, ASP49B, ASP75B, ASP87A, CYS125A, CYS138A, GLN103B, GLN119B, GLN1B, GLN36B, GLN55B, GLN98A, GLN98B, GLU151A, GLU191A, GLU204B, GLU47A, GLU54B, GLY143A, GLY20A, GLY71B, ILE104B, ILE116B, ILE152A, ILE38B, ILE73B, ILE88A, LEU100B, LEU121A, LEU121B, LEU4B, LEU50B, LEU60A, LEU7B, LYS141A, LYS171B, LYS23A, LYS40A, LYS40B, LYS8B, MET114B, MET124A, MET17A, MET5B, PHE115B, PHE123A, PHE150A, PHE76B, PRO102B, PRO117B, PRO127A, PRO16A, PRO19A, PRO21A, PRO86A, PRO96A, SER101B, SER122A, SER122B, SER144A, SER148A, SER15A, SER165B, SER169B, SER170B, SER43A, SER44A, SER62A, SER79B, SER92A, SER93A, SER9B, THR128A, THR137A, THR22A, THR34B, THR45A, THR74B, THR78B, THR85A, THR89A, THR94A, TRP145A, TRP84A, TYR147A, TYR166B, TYR167B, TYR172B, TYR18A, TYR193A, TYR52B, TYR53B, TYR70B, TYR91A, VAL106B, VAL140A, VAL146A, VAL39B, VAL41B, VAL48A, VAL51B, VAL97A, VAL97B, VAL99B
• A-E: ALA105A, ALA118A, ALA139E, ALA168A, ALA2A, ALA90E, ARG120A, ARG205A, ARG6A, ARG77A, ARG95E, ASN13A, ASN3A, ASN46E, ASN61E, ASN72A, ASP126E, ASP24E, ASP25E, ASP37A, ASP42E, ASP49A, ASP75A, ASP87E, CYS125E, CYS138E, GLN103A, GLN119A, GLN1A, GLN36A, GLN98A, GLN98E, GLU151E, GLU191E, GLU47E, GLU54A, GLY143E, GLY20E, GLY71A, ILE104A, ILE116A, ILE152E, ILE38A, ILE73A, ILE88E, LEU100A, LEU121E, LEU4A, LEU50A, LEU60E, LEU7A, LYS141E, LYS171A, LYS23E, LYS40A, LYS8A, MET114A, MET124E, MET17E, MET5A, PHE115A, PHE123E, PHE76A, PRO102A, PRO117A, PRO127E, PRO16E, PRO19E, PRO21E, PRO86E, PRO96E, SER101A, SER122E, SER144E, SER148E, SER15E, SER164A, SER165A, SER169A, SER170A, SER43E, SER44E, SER62E, SER79A, SER92E, SER93E, SER9A, THR128E, THR137E, THR22E, THR34A, THR45E, THR74A, THR78A, THR85E, THR89E, THR94E, TRP145E, TRP84E, TYR147E, TYR166A, TYR167A, TYR172A, TYR186E, TYR18E, TYR193E, TYR52A, TYR53A, TYR91E, VAL106A, VAL146E, VAL39A, VAL41A, VAL48E, VAL51A, VAL97A, VAL97E, VAL99A
• A-H: ARG14A, ARG14H, PRO16A, PRO16H, SER15A, SER15H
• A-I: ALA2A, ALA2I, ARG14A, ARG14I, ARG6A, ARG6I, ASN13A, ASN3A, ASN3I, ASN68A, ASN68I, ASN72A, ASN72I, ASP10A, ASP10I, ASP66A, ASP66I, GLN1I, GLU69A, GLU69I, GLY71A, GLY71I, LEU4I, LEU7A, LEU7I, MET5A, MET5I, PRO67A, PRO67I, SER9A, SER9I, TRP65A, TRP65I, TYR70A, TYR70I
• A-K: ALA9K, ARG11K, ARG7K, ASP195A, ASP5K, ASP87A, CYS12K, CYS188A, CYS189A, CYS2K, CYS3K, CYS8K, GLN182A, GLN184A, GLU151A, GLU191A, GLY143A, GLY149A, GLY1K, HIS185A, ILE152A, ILE194A, ILE88A, LEU154A, LYS141A, LYS23A, PHE142A, PHE150A, PRO190A, PRO192A, PRO6K, SER144A, SER148A, SER187A, SER4K, THR89A, TRP10K, TRP145A, TYR147A, TYR186A, TYR193A, TYR91A, VAL146A, VAL183A, VAL196A
• A-O: ALA105A, ALA118A, ALA9O, ARG11O, ARG57A, ARG77A, ARG7O, ASP157A, ASP162A, ASP5O, ASP75A, CYS12O, CYS2O, CYS3O, CYS8O, GLN36A, GLN55A, GLN56A, GLY1O, HIS109A, ILE116A, LEU163A, LEU35A, MET114A, PHE115A, PHE33A, PHE76A, PRO102A, PRO117A, PRO6O, SER101A, SER112A, SER164A, SER165A, SER4O, THR108A, THR158A, THR34A, THR74A, TRP10O, TYR166A, TYR53A, VAL106A, VAL107A, VAL113A
• B-C: ALA105C, ALA118C, ALA139B, ALA168C, ALA2C, ALA80C, ALA90B, ARG120C, ARG205C, ARG6C, ARG77C, ARG95B, ARG95C, ASN13C, ASN3C, ASN46B, ASN61B, ASN72C, ASP126B, ASP24B, ASP25B, ASP37C, ASP42B, ASP49C, ASP75C, ASP87B, CYS125B, CYS138B, CYS188B, CYS189B, GLN103C, GLN119C, GLN1C, GLN36C, GLN55C, GLN98B, GLN98C, GLU151B, GLU191B, GLU47B, GLU54C, GLY143B, GLY20B, GLY71C, ILE104C, ILE116C, ILE152B, ILE38C, ILE73C, ILE88B, LEU100C, LEU121B, LEU35C, LEU4C, LEU50C, LEU60B, LEU7C, LYS141B, LYS171C, LYS23B, LYS40C, LYS8C, MET114C, MET124B, MET17B, MET5C, PHE115C, PHE123B, PHE150B, PHE76C, PRO102C, PRO117C, PRO127B, PRO16B, PRO19B, PRO21B, PRO86B, PRO96B, SER101C, SER122B, SER122C, SER144B, SER148B, SER15B, SER164C, SER165C, SER169C, SER170C, SER43B, SER44B, SER62B, SER79C, SER92B, SER93B, SER9C, THR128B, THR137B, THR22B, THR34C, THR45B, THR74C, THR78C, THR85B, THR89B, THR94B, TRP145B, TRP84B, TYR147B, TYR166C, TYR167C, TYR172C, TYR186B, TYR18B, TYR193B, TYR52C, TYR53C, TYR91B, VAL106C, VAL140B, VAL146B, VAL39C, VAL41C, VAL48B, VAL51C, VAL97B, VAL97C, VAL99C
• B-G: ARG14B, ARG14G, PRO16B, PRO16G, SER15B, SER15G
• B-H: ALA2B, ALA2H, ARG14B, ARG14H, ARG6B, ARG6H, ASN13B, ASN3B, ASN3H, ASN68B, ASN68H, ASN72B, ASN72H, ASP10B, ASP10H, ASP66B, ASP66H, GLN1B, GLU69B, GLU69H, GLY71B, GLY71H, LEU4B, LEU7B, LEU7H, LYS8B, MET5B, MET5H, PRO67B, PRO67H, SER9B, SER9H, TRP65B, TYR70B, TYR70H
• B-K: ALA105B, ALA118B, ALA9K, ARG11K, ARG57B, ARG77B, ARG7K, ASP157B, ASP162B, ASP5K, ASP75B, CYS12K, CYS2K, CYS3K, CYS8K, GLN55B, GLN56B, GLY1K, HIS109B, ILE104B, ILE116B, LEU163B, LEU35B, MET114B, PHE115B, PHE76B, PRO102B, PRO117B, PRO6K, SER101B, SER112B, SER164B, SER165B, SER4K, THR108B, THR30B, THR34B, THR74B, TRP10K, TYR166B, TYR53B, VAL106B, VAL107B, VAL113B
• C-D: ALA105D, ALA118D, ALA139C, ALA168D, ALA2D, ALA90C, ARG120D, ARG205D, ARG6D, ARG77D, ARG95C, ARG95D, ASN13D, ASN3D, ASN46C, ASN61C, ASN72D, ASP126C, ASP24C, ASP25C, ASP37D, ASP42C, ASP49D, ASP75D, ASP87C, CYS125C, CYS138C, GLN103D, GLN119D, GLN1D, GLN36D, GLN55D, GLN98C, GLN98D, GLU151C, GLU191C, GLU47C, GLU54D, GLY143C, GLY20C, GLY71D, ILE104D, ILE116D, ILE152C, ILE38D, ILE73D, ILE88C, LEU100D, LEU121C, LEU121D, LEU35D, LEU4D, LEU50D, LEU60C, LEU7D, LYS141C, LYS171D, LYS23C, LYS40D, LYS8D, MET114D, MET124C, MET17C, MET5D, PHE115D, PHE123C, PHE76D, PRO102D, PRO117D, PRO127C, PRO16C, PRO19C, PRO21C, PRO26C, PRO86C, PRO96C, SER101D, SER122C, SER122D, SER144C, SER148C, SER15C, SER165D, SER169D, SER170D, SER43C, SER44C, SER62C, SER79D, SER92C, SER93C, SER9D, THR128C, THR137C, THR22C, THR34D, THR45C, THR74D, THR78D, THR85C, THR89C, THR94C, TRP145C, TRP84C, TYR147C, TYR166D, TYR167D, TYR172D, TYR18C, TYR193C, TYR52D, TYR53D, TYR91C, VAL106D, VAL140C, VAL146C, VAL39D, VAL41D, VAL48C, VAL51D, VAL97C, VAL97D, VAL99D
• C-F: ARG14C, ARG14F, PRO16C, PRO16F, SER15C, SER15F
• C-G: ALA2C, ALA2G, ARG14C, ARG14G, ARG6C, ARG6G, ASN3C, ASN3G, ASN68C, ASN68G, ASN72C, ASN72G, ASP10C, ASP10G, ASP66C, ASP66G, GLU69C, GLU69G, GLY71C, GLY71G, LEU7C, LEU7G, MET5C, MET5G, PRO67C, PRO67G, SER9C, SER9G, TRP65C, TYR70C, TYR70G
• C-M: ALA9M, ARG11M, ARG7M, ASP195C, ASP5M, ASP87C, CYS12M, CYS188C, CYS189C, CYS2M, CYS3M, CYS8M, GLN182C, GLN184C, GLU151C, GLU191C, GLY143C, GLY149C, GLY1M, HIS185C, ILE152C, ILE194C, ILE88C, LEU154C, LYS141C, LYS23C, PHE142C, PHE150C, PRO190C, PRO192C, PRO6M, SER144C, SER148C, SER187C, SER4M, THR89C, TRP10M, TRP145C, TYR147C, TYR186C, TYR193C, TYR91C, VAL146C, VAL183C, VAL196C
• D-E: ALA105E, ALA118E, ALA139D, ALA168E, ALA2E, ALA80E, ALA90D, ARG120E, ARG205E, ARG6E, ARG77E, ARG95D, ARG95E, ASN13E, ASN3E, ASN46D, ASN61D, ASN72E, ASP126D, ASP24D, ASP25D, ASP37E, ASP42D, ASP49E, ASP75E, ASP87D, CYS125D, CYS138D, CYS188D, CYS189D, GLN103E, GLN119E, GLN1E, GLN36E, GLN55E, GLN98D, GLN98E, GLU151D, GLU191D, GLU47D, GLU54E, GLY143D, GLY149D, GLY20D, GLY71E, ILE104E, ILE116E, ILE152D, ILE38E, ILE73E, ILE88D, LEU100E, LEU121D, LEU121E, LEU27D, LEU35E, LEU4E, LEU50E, LEU60D, LEU7E, LYS141D, LYS171E, LYS23D, LYS40E, LYS8E, MET114E, MET124D, MET17D, MET5E, PHE115E, PHE123D, PHE150D, PHE76E, PRO102E, PRO117E, PRO127D, PRO16D, PRO19D, PRO21D, PRO26D, PRO67E, PRO86D, PRO96D, PRO96E, SER101E, SER122D, SER122E, SER144D, SER148D, SER15D, SER164E, SER165E, SER169E, SER170E, SER43D, SER44D, SER62D, SER79E, SER92D, SER93D, SER9E, THR128D, THR137D, THR22D, THR34E, THR45D, THR74E, THR78E, THR85D, THR89D, THR94D, TRP145D, TRP84D, TYR147D, TYR166E, TYR167E, TYR172E, TYR186D, TYR18D, TYR193D, TYR52E, TYR53E, TYR70E, TYR91D, VAL106E, VAL107E, VAL140D, VAL146D, VAL39E, VAL41E, VAL48D, VAL51E, VAL97D, VAL97E, VAL99E
• D-F: ALA2D, ALA2F, ARG14D, ARG14F, ARG6D, ARG6F, ASN3D, ASN3F, ASN68D, ASN68F, ASN72D, ASN72F, ASP10D, ASP10F, ASP66D, ASP66F, GLU69D, GLU69F, GLY71D, GLY71F, LEU7D, LEU7F, MET5D, MET5F, PRO67D, PRO67F, SER9D, SER9F, TRP65D, TYR70D, TYR70F
• D-J: ARG14D, ARG14J, PRO16D, PRO16J, SER15D, SER15J
• D-M: ALA105D, ALA118D, ALA9M, ARG11M, ARG57D, ARG77D, ARG7M, ASP157D, ASP162D, ASP5M, ASP75D, CYS12M, CYS2M, CYS3M, CYS8M, GLN55D, GLN56D, GLY1M, HIS109D, ILE104D, ILE116D, LEU163D, MET114D, PHE115D, PHE76D, PRO102D, PRO117D, PRO6M, SER101D, SER112D, SER164D, SER165D, SER4M, THR108D, THR34D, THR74D, TRP10M, TYR53D, VAL106D, VAL107D, VAL113D
• E-I: ARG14E, ARG14I, ASN13E, PRO16E, PRO16I, SER15E, SER15I
• E-J: ALA2E, ALA2J, ARG14E, ARG14J, ARG6E, ARG6J, ASN13E, ASN13J, ASN3E, ASN3J, ASN68E, ASN68J, ASN72E, ASN72J, ASP10E, ASP10J, ASP66E, ASP66J, GLN1E, GLN1J, GLU69E, GLU69J, GLY71E, GLY71J, ILE73J, LEU11J, LEU7E, LEU7J, MET5E, MET5J, PRO67E, PRO67J, SER9E, SER9J, TRP65J, TYR70E, TYR70J
• E-O: ALA9O, ARG11O, ARG7O, ASP195E, ASP5O, ASP87E, CYS12O, CYS188E, CYS189E, CYS2O, CYS3O, CYS8O, GLN182E, GLN184E, GLU151E, GLU191E, GLY143E, GLY149E, GLY1O, HIS185E, ILE152E, ILE194E, ILE88E, LEU154E, LYS141E, LYS23E, PHE142E, PHE150E, PRO190E, PRO192E, PRO6O, SER144E, SER148E, SER187E, SER4O, THR89E, TRP10O, TRP145E, TYR147E, TYR186E, TYR193E, TYR91E, VAL146E, VAL183E, VAL196E
• F-G: ALA105G, ALA118G, ALA139F, ALA168G, ALA2G, ALA90F, ARG120G, ARG205G, ARG6G, ARG77G, ARG95F, ARG95G, ASN13G, ASN3G, ASN46F, ASN61F, ASN72G, ASP126F, ASP24F, ASP25F, ASP37G, ASP42F, ASP49G, ASP75G, ASP87F, CYS125F, CYS138F, GLN103G, GLN119G, GLN1G, GLN36G, GLN55G, GLN98F, GLN98G, GLU151F, GLU191F, GLU47F, GLU54G, GLY143F, GLY20F, GLY71G, ILE104G, ILE116G, ILE152F, ILE38G, ILE73G, ILE88F, LEU100G, LEU121F, LEU121G, LEU27F, LEU4G, LEU50G, LEU60F, LEU7G, LYS141F, LYS171G, LYS23F, LYS40G, LYS8G, MET114G, MET124F, MET17F, MET5G, PHE115G, PHE123F, PHE76G, PRO102G, PRO117G, PRO127F, PRO16F, PRO19F, PRO21F, PRO86F, PRO96F, PRO96G, SER101G, SER122F, SER122G, SER144F, SER148F, SER15F, SER165G, SER169G, SER170G, SER43F, SER44F, SER62F, SER79G, SER92F, SER93F, SER9G, THR128F, THR137F, THR22F, THR34G, THR45F, THR74G, THR78G, THR85F, THR89F, THR94F, TRP145F, TRP84F, TYR147F, TYR166G, TYR167G, TYR172G, TYR18F, TYR193F, TYR52G, TYR53G, TYR91F, VAL106G, VAL140F, VAL146F, VAL39G, VAL41G, VAL48F, VAL51G, VAL97F, VAL97G, VAL99G
• F-J: ALA105F, ALA118F, ALA139J, ALA168F, ALA2F, ALA90J, ARG120F, ARG205F, ARG6F, ARG77F, ARG95F, ARG95J, ASN13F, ASN3F, ASN46J, ASN61J, ASN72F, ASP126J, ASP24J, ASP25J, ASP37F, ASP42J, ASP49F, ASP75F, ASP87J, CYS125J, CYS138J, GLN103F, GLN119F, GLN1F, GLN36F, GLN55F, GLN98F, GLN98J, GLU151J, GLU191J, GLU47J, GLU54F, GLY143J, GLY20J, GLY71F, ILE104F, ILE116F, ILE152J, ILE38F, ILE73F, ILE88J, LEU100F, LEU121F, LEU121J, LEU27J, LEU35F, LEU4F, LEU50F, LEU60J, LEU7F, LYS141J, LYS171F, LYS23J, LYS40F, LYS8F, MET114F, MET124J, MET17J, MET5F, PHE115F, PHE123J, PHE150J, PHE76F, PRO102F, PRO117F, PRO127J, PRO16J, PRO19J, PRO21J, PRO26J, PRO67F, PRO86J, PRO96F, PRO96J, SER101F, SER122F, SER122J, SER144J, SER148J, SER15J, SER165F, SER169F, SER170F, SER43J, SER44J, SER62J, SER79F, SER92J, SER93J, SER9F, THR128J, THR137J, THR22J, THR34F, THR45J, THR74F, THR78F, THR85J, THR89J, THR94J, TRP145J, TRP84J, TYR147J, TYR166F, TYR167F, TYR172F, TYR18J, TYR193J, TYR52F, TYR53F, TYR91J, VAL106F, VAL140J, VAL146J, VAL39F, VAL41F, VAL48J, VAL51F, VAL97F, VAL97J, VAL99F
• F-P: ALA9P, ARG11P, ARG7P, ASP195F, ASP5P, ASP87F, CYS12P, CYS188F, CYS189F, CYS2P, CYS3P, CYS8P, GLN182F, GLN184F, GLU151F, GLU191F, GLY143F, GLY149F, GLY1P, HIS185F, ILE152F, ILE194F, ILE88F, LEU154F, LYS141F, LYS23F, PHE142F, PHE150F, PRO190F, PRO192F, PRO6P, SER144F, SER148F, SER187F, SER4P, THR89F, TRP10P, TRP145F, TYR147F, TYR186F, TYR193F, TYR91F, VAL146F, VAL183F, VAL196F
• F-T: ALA105F, ALA118F, ALA9T, ARG11T, ARG57F, ARG77F, ARG7T, ASP157F, ASP162F, ASP5T, ASP75F, CYS12T, CYS2T, CYS3T, CYS8T, GLN36F, GLN55F, GLY1T, HIS109F, ILE116F, LEU163F, MET114F, PHE115F, PHE76F, PRO102F, PRO117F, PRO6T, SER101F, SER112F, SER164F, SER165F, SER4T, THR108F, THR34F, THR74F, TRP10T, TYR53F, VAL106F, VAL107F, VAL113F
• G-H: ALA105H, ALA118H, ALA139G, ALA168H, ALA2H, ALA90G, ARG120H, ARG205H, ARG6H, ARG77H, ARG95G, ASN13H, ASN3H, ASN46G, ASN61G, ASN72H, ASP126G, ASP24G, ASP25G, ASP37H, ASP42G, ASP49H, ASP75H, ASP87G, CYS125G, CYS138G, GLN103H, GLN119H, GLN1H, GLN36H, GLN98G, GLN98H, GLU151G, GLU191G, GLU47G, GLU54H, GLY143G, GLY20G, GLY71H, ILE104H, ILE116H, ILE152G, ILE38H, ILE73H, ILE88G, LEU100H, LEU121G, LEU121H, LEU35H, LEU4H, LEU50H, LEU60G, LEU7H, LYS141G, LYS171H, LYS23G, LYS40H, LYS8H, MET114H, MET124G, MET17G, MET5H, PHE115H, PHE123G, PHE76H, PRO102H, PRO117H, PRO127G, PRO16G, PRO19G, PRO21G, PRO86G, PRO96G, SER101H, SER122G, SER122H, SER144G, SER148G, SER15G, SER165H, SER169H, SER170H, SER43G, SER44G, SER62G, SER79H, SER92G, SER93G, SER9H, THR128G, THR137G, THR22G, THR34H, THR45G, THR74H, THR78H, THR85G, THR89G, THR94G, TRP145G, TRP84G, TYR147G, TYR166H, TYR167H, TYR172H, TYR18G, TYR193G, TYR52H, TYR53H, TYR70H, TYR91G, VAL106H, VAL146G, VAL39H, VAL41H, VAL48G, VAL51H, VAL97G, VAL97H, VAL99H
• G-P: ALA105G, ALA118G, ALA9P, ARG11P, ARG57G, ARG77G, ARG7P, ASP157G, ASP162G, ASP5P, ASP75G, CYS12P, CYS2P, CYS3P, CYS8P, GLN55G, GLN56G, GLY1P, HIS109G, ILE104G, ILE116G, LEU163G, MET114G, PHE115G, PHE76G, PRO102G, PRO117G, PRO6P, SER101G, SER112G, SER164G, SER165G, SER4P, THR108G, THR30G, THR34G, THR74G, TRP10P, TYR53G, VAL106G, VAL107G, VAL113G
• G-Q: ALA9Q, ARG11Q, ARG7Q, ASP195G, ASP5Q, ASP87G, CYS12Q, CYS188G, CYS189G, CYS2Q, CYS3Q, CYS8Q, GLN182G, GLN184G, GLU151G, GLU191G, GLY143G, GLY149G, GLY1Q, HIS185G, ILE152G, ILE194G, ILE88G, LEU154G, LYS141G, LYS23G, PHE142G, PHE150G, PRO190G, PRO192G, PRO6Q, SER144G, SER148G, SER187G, SER4Q, THR89G, TRP10Q, TRP145G, TYR147G, TYR186G, TYR193G, TYR91G, VAL146G, VAL183G, VAL196G
• H-I: ALA105I, ALA118I, ALA139H, ALA168I, ALA2I, ALA80I, ALA90H, ARG120I, ARG205I, ARG6I, ARG77I, ARG95H, ARG95I, ASN13I, ASN3I, ASN46H, ASN61H, ASN72I, ASP126H, ASP24H, ASP25H, ASP37I, ASP42H, ASP49I, ASP75I, ASP87H, CYS125H, CYS138H, GLN103I, GLN119I, GLN1I, GLN36I, GLN55I, GLN98H, GLN98I, GLU151H, GLU191H, GLU47H, GLU54I, GLY143H, GLY20H, GLY71I, ILE104I, ILE116I, ILE152H, ILE38I, ILE73I, ILE88H, LEU100I, LEU121H, LEU121I, LEU27H, LEU35I, LEU4I, LEU50I, LEU60H, LEU63H, LEU7I, LYS141H, LYS171I, LYS23H, LYS40I, LYS59H, LYS8I, MET114I, MET124H, MET17H, MET5I, PHE115I, PHE123H, PHE76I, PRO102I, PRO117I, PRO127H, PRO16H, PRO19H, PRO21H, PRO26H, PRO86H, PRO96H, PRO96I, SER101I, SER122H, SER122I, SER144H, SER148H, SER15H, SER165I, SER169I, SER170I, SER43H, SER44H, SER62H, SER79I, SER92H, SER93H, SER9I, THR128H, THR137H, THR22H, THR34I, THR45H, THR74I, THR78I, THR85H, THR89H, THR94H, TRP145H, TRP84H, TYR147H, TYR166I, TYR167I, TYR172I, TYR18H, TYR193H, TYR52I, TYR53I, TYR70I, TYR91H, VAL106I, VAL140H, VAL146H, VAL39I, VAL41I, VAL48H, VAL51I, VAL97H, VAL97I, VAL99I
• H-Q: ALA105H, ALA118H, ALA9Q, ARG11Q, ARG57H, ARG77H, ARG7Q, ASP157H, ASP162H, ASP5Q, ASP75H, CYS12Q, CYS2Q, CYS3Q, CYS8Q, GLN36H, GLN55H, GLN56H, GLY1Q, HIS109H, ILE104H, ILE116H, LEU163H, LEU35H, MET114H, PHE115H, PHE33H, PHE76H, PRO102H, PRO117H, PRO6Q, SER101H, SER112H, SER164H, SER165H, SER4Q, THR108H, THR30H, THR34H, THR74H, TRP10Q, TYR166H, TYR53H, VAL106H, VAL107H, VAL113H
• H-R: ALA9R, ARG11R, ARG7R, ASP195H, ASP5R, ASP87H, CYS12R, CYS188H, CYS189H, CYS2R, CYS3R, CYS8R, GLN182H, GLN184H, GLU151H, GLU191H, GLY143H, GLY149H, GLY1R, HIS185H, ILE152H, ILE194H, ILE88H, LEU154H, LYS141H, LYS23H, PHE142H, PRO190H, PRO192H, PRO6R, SER144H, SER148H, SER187H, SER4R, THR89H, TRP10R, TRP145H, TYR147H, TYR186H, TYR193H, TYR91H, VAL146H, VAL183H, VAL196H
• I-J: ALA105J, ALA118J, ALA139I, ALA168J, ALA2J, ALA90I, ARG120J, ARG14I, ARG205J, ARG6J, ARG77J, ARG95I, ARG95J, ASN13J, ASN3J, ASN46I, ASN61I, ASN72J, ASP126I, ASP24I, ASP25I, ASP37J, ASP42I, ASP49J, ASP75J, ASP87I, CYS125I, CYS138I, GLN103J, GLN119J, GLN1J, GLN36J, GLN55J, GLN98I, GLN98J, GLU151I, GLU191I, GLU47I, GLU54J, GLY143I, GLY20I, GLY71J, ILE104J, ILE116J, ILE152I, ILE38J, ILE73J, ILE88I, LEU100J, LEU121I, LEU121J, LEU35J, LEU4J, LEU50J, LEU60I, LEU7J, LYS141I, LYS171J, LYS23I, LYS40J, LYS8J, MET114J, MET124I, MET17I, MET5J, PHE115J, PHE123I, PHE76J, PRO102J, PRO117J, PRO127I, PRO16I, PRO19I, PRO21I, PRO26I, PRO86I, PRO96I, SER101J, SER122I, SER122J, SER144I, SER148I, SER15I, SER165J, SER169J, SER170J, SER43I, SER44I, SER62I, SER79J, SER92I, SER93I, SER9J, THR128I, THR137I, THR22I, THR34J, THR45I, THR74J, THR78J, THR85I, THR89I, THR94I, TRP145I, TRP84I, TYR147I, TYR166J, TYR167J, TYR172J, TYR18I, TYR193I, TYR52J, TYR53J, TYR70J, TYR91I, VAL106J, VAL140I, VAL146I, VAL39J, VAL41J, VAL48I, VAL51J, VAL97I, VAL97J, VAL99J
• I-R: ALA105I, ALA118I, ALA9R, ARG11R, ARG57I, ARG77I, ARG7R, ASP157I, ASP162I, ASP5R, ASP75I, CYS12R, CYS2R, CYS3R, CYS8R, GLN55I, GLN56I, GLY1R, HIS109I, ILE104I, ILE116I, LEU163I, MET114I, PHE115I, PHE33I, PHE76I, PRO102I, PRO117I, PRO6R, SER101I, SER112I, SER164I, SER165I, SER4R, THR108I, THR34I, THR74I, TRP10R, TYR53I, VAL106I, VAL107I, VAL113I
• I-S: ALA9S, ARG11S, ARG7S, ASP195I, ASP5S, ASP87I, CYS12S, CYS188I, CYS189I, CYS2S, CYS3S, CYS8S, GLN182I, GLN184I, GLU151I, GLU191I, GLY143I, GLY149I, GLY1S, HIS185I, ILE152I, ILE194I, LEU154I, LYS141I, LYS23I, PHE142I, PHE150I, PRO190I, PRO192I, PRO6S, SER144I, SER148I, SER187I, SER4S, THR89I, TRP10S, TRP145I, TYR147I, TYR186I, TYR193I, TYR91I, VAL146I, VAL183I, VAL196I
• J-S: ALA105J, ALA118J, ALA9S, ARG11S, ARG57J, ARG77J, ARG7S, ASP157J, ASP162J, ASP5S, ASP75J, CYS12S, CYS2S, CYS3S, CYS8S, GLN55J, GLN56J, GLY1S, HIS109J, ILE104J, ILE116J, LEU163J, MET114J, PHE115J, PHE76J, PRO102J, PRO117J, PRO6S, SER101J, SER112J, SER164J, SER165J, SER4S, THR108J, THR34J, THR74J, TRP10S, TYR53J, VAL106J, VAL107J, VAL113J
• J-T: ALA9T, ARG11T, ARG7T, ASP195J, ASP5T, ASP87J, CYS12T, CYS188J, CYS189J, CYS2T, CYS3T, CYS8T, GLN182J, GLN184J, GLU151J, GLU191J, GLY143J, GLY149J, GLY1T, HIS185J, ILE152J, ILE194J, LEU154J, LYS141J, LYS23J, PHE142J, PHE150J, PRO190J, PRO192J, PRO6T, SER144J, SER148J, SER187J, SER4T, THR89J, TRP10T, TRP145J, TYR147J, TYR186J, TYR193J, TYR91J, VAL146J, VAL183J, VAL196J