2C9B

lumazine synthase from mycobacterium tuberculosis bound to 3-(1,3,7-trihydro-9-d-ribityl-2,6,8-purinetrione-7-yl)

• Total interactions analyzed: 45
• Total true interactions: 35
• Strongest Interaction:
  • Chains: E-G
  • Int. Res.: 12
  • Norm. En. per Res.: -5.8873
• Hub Node: A(7)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-18.1644	-14.4709	-212.023	-244.6583	102	8	4	10178	3	15	17
A-C	0.0	0.0	-0.0126	-0.0126	4	0	0	9	0	0	4
A-D	0.0	0.0	-0.0061	-0.0061	5	0	0	9	0	0	4
A-E	-18.3647	13.1072	-217.131	-222.3886	105	5	5	10314	3	17	17
A-F	-10.2831	-40.1007	-15.2017	-65.5854	13	3	0	676	4	2	2
A-G	-14.6058	53.6509	-123.034	-83.9888	70	12	2	5628	4	30	29
A-H	0.0	0.0	-29.6444	-29.6444	16	2	2	1110	0	4	9
B-C	-26.1377	15.8492	-241.853	-252.1415	105	10	8	11258	2	16	17
B-D	0.0	0.0	-0.0008	-0.0008	3	0	0	2	0	0	3
B-E	0.0	0.0	-0.001	-0.001	4	0	0	3	0	0	3
B-F	-22.3288	28.5388	-135.391	-129.181	70	12	2	5444	6	31	29
B-G	0.0	0.0	-24.4207	-24.4207	15	2	2	1012	0	4	9
B-J	0.0	-17.9218	-22.1641	-40.0859	14	1	0	717	2	3	2
C-D	-11.1515	17.6889	-221.336	-214.7987	105	5	5	10590	3	17	17
C-E	0.0	0.0	-0.001	-0.001	5	0	0	3	0	0	4
C-F	0.0	-2.5053	-29.0751	-31.5804	16	2	2	1089	0	4	9
C-I	-12.2812	-39.5768	-24.4203	-76.2783	14	0	0	707	4	3	2
C-J	-26.38	43.2164	-133.625	-116.7886	66	4	2	5194	6	31	30
D-E	-3.4275	10.3551	-238.212	-231.2845	105	6	5	10768	3	18	17
D-H	-8.6053	-40.0219	-17.2324	-65.8596	12	1	0	672	4	3	2
D-I	-8.6192	44.5438	-120.54	-84.6153	69	11	2	5358	7	31	31
D-J	0.0	0.0	-20.8715	-20.8715	14	1	2	930	0	4	9
E-G	-12.9338	-35.9057	-21.808	-70.6475	12	1	0	683	4	3	2
E-H	-31.979	22.9402	-132.051	-141.0898	69	8	2	5493	6	30	31
E-I	0.0	-1.3882	-30.7134	-32.1016	15	2	2	1121	0	4	9
F-G	-16.2834	16.2518	-211.918	-211.9496	106	3	4	10319	3	18	17
F-H	0.0	0.0	-0.0119	-0.0119	4	0	0	7	0	0	5
F-I	0.0	0.0	-0.0076	-0.0076	5	0	0	8	0	0	4
F-J	-13.9899	-15.0877	-236.731	-265.8085	108	6	6	10979	3	18	17
G-H	-17.3195	19.6618	-238.034	-235.6917	103	15	5	11190	3	16	16
G-I	0.0	0.0	-0.0033	-0.0033	5	0	0	4	0	0	4
G-J	0.0	0.0	-0.0012	-0.0012	5	0	0	3	0	0	3
H-I	-12.2441	-25.3052	-211.538	-249.0874	105	6	6	10275	3	17	17
H-J	0.0	0.0	-0.0008	-0.0008	4	0	0	2	0	0	4
I-J	-6.2932	12.995	-222.336	-215.6342	105	4	4	10369	3	14	17

Interface residues

• A-B: ALA113B, ALA125B, ALA140B, ALA142B, ALA145B, ALA146B, ALA148B, ALA150B, ALA158B, ALA66A, ALA96A, ALA96B, ARG103A, ARG103B, ARG128B, ARG154B, ARG157B, ARG55A, ARG71A, ARG84B, ASN114B, ASN120B, ASN72A, ASP107A, ASP107B, ASP91A, ASP91B, ASP95A, ASP95B, CYS94A, CYS94B, GLN124B, GLN141B, GLN67A, GLN86A, GLN99A, GLN99B, GLU136B, GLU155B, GLU61A, GLU68A, GLY100A, GLY100B, GLY115B, GLY58A, GLY85A, HIS73A, HIS89A, ILE112B, ILE60A, ILE62A, ILE83B, LEU101A, LEU101B, LEU106B, LEU117B, LEU147B, LEU153B, LEU156B, LEU57A, LEU69A, LYS138B, PHE90A, PHE90B, PRO111B, PRO63A, PRO88A, SER105A, SER105B, SER108B, SER109B, THR102A, THR102B, THR110B, THR118B, THR119B, THR121B, THR143B, THR149B, THR152B, THR52A, THR87A, THR98A, THR98B, TRP27A, TYR92A, TYR92B, VAL104A, VAL104B, VAL116B, VAL144B, VAL23A, VAL53A, VAL54A, VAL56A, VAL64A, VAL65A, VAL82B, VAL93A, VAL93B, VAL97A, VAL97B
• A-C: ARG103A, GLN99A, GLN99C, LEU106C
• A-D: ARG103D, GLN99A, GLN99D, LEU106A, THR102A
• A-E: ALA113A, ALA125A, ALA142A, ALA145A, ALA146A, ALA148A, ALA150A, ALA158A, ALA21E, ALA66E, ALA96A, ALA96E, ARG103A, ARG103E, ARG128A, ARG154A, ARG157A, ARG55E, ARG71E, ARG84A, ASN114A, ASN120A, ASN72E, ASP107A, ASP107E, ASP127A, ASP137A, ASP74A, ASP91A, ASP91E, ASP95A, ASP95E, CYS94A, CYS94E, GLN124A, GLN141A, GLN67E, GLN86E, GLN99A, GLN99E, GLU136A, GLU155A, GLU61E, GLU68E, GLY100A, GLY100E, GLY115A, GLY58E, GLY85E, HIS73E, HIS89E, ILE112A, ILE60E, ILE62E, ILE83A, LEU101A, LEU101E, LEU106A, LEU117A, LEU147A, LEU153A, LEU156A, LEU57E, LEU69E, LYS138A, PHE90A, PHE90E, PRO111A, PRO63E, PRO88E, SER105A, SER105E, SER108A, SER109A, THR102A, THR102E, THR110A, THR118A, THR119A, THR121A, THR143A, THR149A, THR152A, THR52E, THR87E, THR98A, THR98E, TRP27E, TYR92A, TYR92E, VAL104A, VAL104E, VAL116A, VAL144A, VAL23E, VAL53E, VAL54E, VAL56E, VAL64E, VAL65E, VAL82A, VAL93A, VAL93E, VAL97A, VAL97E
• A-F: ALA70F, ARG71A, ARG71F, ASN72A, ASN72F, GLN67A, GLN67F, GLU68A, GLU68F, LEU69A, LEU69F, VAL64A, VAL64F
• A-G: ALA150A, ALA150G, ALA158A, ALA158G, ALA21A, ALA21G, ALA70A, ALA70G, ALA75G, ARG154A, ARG154G, ARG157A, ARG157G, ARG19A, ARG19G, ARG40A, ARG40G, ARG71A, ARG71G, ASN72A, ASN72G, ASP107G, ASP50A, ASP50G, ASP74A, ASP74G, GLU155A, GLU155G, GLU68A, GLU68G, GLY17A, GLY17G, HIS159A, HIS159G, HIS73A, HIS73G, ILE22A, ILE22G, LEU106A, LEU106G, LEU151A, LEU151G, LEU153A, LEU153G, LEU156A, LEU156G, LEU20A, LEU20G, LEU69A, LEU69G, PRO51A, PRO51G, SER108A, SER108G, SER109A, SER109G, SER160A, SER160G, THR110A, THR110G, THR52A, THR52G, VAL18A, VAL18G, VAL53A, VAL53G, VAL54A, VAL54G, VAL65A, VAL65G
• A-H: ALA158A, ALA158H, ARG157A, ARG157H, GLU155A, GLU155H, HIS159A, HIS159H, LEU153A, LEU153H, LEU156A, LEU156H, SER160A, SER160H, THR152A, THR152H
• B-C: ALA113C, ALA125C, ALA140C, ALA142C, ALA145C, ALA146C, ALA148C, ALA150C, ALA158C, ALA21B, ALA66B, ALA96B, ALA96C, ARG103B, ARG103C, ARG128C, ARG154C, ARG157C, ARG55B, ARG71B, ARG84C, ASN114C, ASN120C, ASN72B, ASP107B, ASP107C, ASP127C, ASP137C, ASP91B, ASP91C, ASP95B, ASP95C, CYS94B, CYS94C, GLN124C, GLN141C, GLN67B, GLN86B, GLN99B, GLN99C, GLU136C, GLU155C, GLU61B, GLU68B, GLY100B, GLY100C, GLY115C, GLY58B, GLY85B, HIS73B, HIS89B, ILE112C, ILE60B, ILE62B, ILE83C, LEU101B, LEU101C, LEU106C, LEU117C, LEU147C, LEU153C, LEU156C, LEU57B, LEU69B, LYS138C, PHE90B, PHE90C, PRO111C, PRO63B, PRO88B, SER105B, SER105C, SER108C, SER109C, THR102B, THR102C, THR110C, THR118C, THR119C, THR121C, THR143C, THR149C, THR152C, THR52B, THR87B, THR98B, THR98C, TRP27B, TYR92B, TYR92C, VAL104B, VAL104C, VAL116C, VAL144C, VAL23B, VAL53B, VAL54B, VAL56B, VAL64B, VAL65B, VAL82C, VAL93B, VAL93C, VAL97B, VAL97C
• B-D: GLN99B, GLN99D, THR102D
• B-E: ARG103E, GLN99B, GLN99E, LEU106B
• B-F: ALA150B, ALA150F, ALA158B, ALA158F, ALA21B, ALA21F, ALA70B, ALA70F, ARG154B, ARG154F, ARG157B, ARG157F, ARG19B, ARG19F, ARG40B, ARG40F, ARG71B, ARG71F, ASN72B, ASN72F, ASP107B, ASP107F, ASP50B, ASP50F, ASP74B, ASP74F, GLU155B, GLU155F, GLU68B, GLU68F, GLY17B, GLY17F, HIS159B, HIS159F, HIS73B, HIS73F, ILE22B, ILE22F, LEU106B, LEU106F, LEU151B, LEU153B, LEU153F, LEU156B, LEU156F, LEU20F, LEU69B, LEU69F, PRO51B, PRO51F, SER108B, SER108F, SER109B, SER109F, SER160B, SER160F, SER16B, SER16F, THR110B, THR110F, THR52B, THR52F, VAL18B, VAL18F, VAL53B, VAL53F, VAL54B, VAL54F, VAL65B, VAL65F
• B-G: ALA158B, ALA158G, ARG157B, ARG157G, GLU155B, GLU155G, HIS159B, HIS159G, LEU153B, LEU153G, LEU156B, LEU156G, SER160B, SER160G, THR152G
• B-J: ALA70B, ALA70J, ARG71B, ARG71J, ASN72B, ASN72J, GLN67B, GLN67J, GLU68B, GLU68J, LEU69B, LEU69J, VAL64B, VAL64J
• C-D: ALA113D, ALA125D, ALA140D, ALA142D, ALA145D, ALA146D, ALA148D, ALA150D, ALA158D, ALA21C, ALA66C, ALA70C, ALA96C, ALA96D, ARG103C, ARG103D, ARG128D, ARG154D, ARG157D, ARG55C, ARG71C, ARG84D, ASN114D, ASN120D, ASN72C, ASP107C, ASP107D, ASP137D, ASP91C, ASP91D, ASP95C, ASP95D, CYS94C, CYS94D, GLN124D, GLN141D, GLN67C, GLN86C, GLN99C, GLN99D, GLU136D, GLU155D, GLU61C, GLU68C, GLY100C, GLY100D, GLY115D, GLY58C, GLY85C, HIS73C, HIS89C, ILE112D, ILE60C, ILE62C, ILE83D, LEU101C, LEU101D, LEU106D, LEU117D, LEU147D, LEU153D, LEU156D, LEU57C, LEU69C, LYS138D, PHE90C, PHE90D, PRO111D, PRO63C, PRO88C, SER105C, SER105D, SER108D, SER109D, THR102C, THR102D, THR110D, THR118D, THR119D, THR121D, THR143D, THR149D, THR152D, THR52C, THR87C, THR98C, THR98D, TRP27C, TYR92C, TYR92D, VAL104C, VAL104D, VAL116D, VAL144D, VAL23C, VAL53C, VAL54C, VAL56C, VAL64C, VAL65C, VAL82D, VAL93C, VAL93D, VAL97C, VAL97D
• C-E: ARG103C, GLN99C, GLN99E, LEU106E, THR102E
• C-F: ALA158C, ALA158F, ARG157C, ARG157F, GLU155C, GLU155F, HIS159C, HIS159F, LEU153C, LEU153F, LEU156C, LEU156F, SER160C, SER160F, THR152C, THR152F
• C-I: ALA70C, ALA70I, ARG71C, ARG71I, ASN72C, ASN72I, GLN67C, GLN67I, GLU68C, GLU68I, LEU69C, LEU69I, VAL64C, VAL64I
• C-J: ALA150C, ALA150J, ALA158C, ALA158J, ALA21C, ALA21J, ALA70C, ALA70J, ARG154C, ARG154J, ARG157C, ARG157J, ARG19C, ARG19J, ARG40C, ARG71C, ARG71J, ASN72C, ASN72J, ASP107J, ASP50C, ASP50J, ASP74C, ASP74J, GLU155C, GLU155J, GLU68C, GLU68J, GLY17C, GLY17J, HIS159C, HIS159J, HIS73C, HIS73J, LEU106C, LEU106J, LEU151C, LEU151J, LEU153C, LEU153J, LEU156C, LEU156J, LEU20J, LEU69C, LEU69J, PRO51C, PRO51J, SER108C, SER108J, SER109C, SER109J, SER160C, SER160J, SER16C, SER16J, THR110C, THR52C, THR52J, VAL18C, VAL18J, VAL53C, VAL53J, VAL54C, VAL54J, VAL65C, VAL65J
• D-E: ALA113E, ALA125E, ALA140E, ALA142E, ALA145E, ALA146E, ALA148E, ALA150E, ALA158E, ALA21D, ALA66D, ALA96D, ALA96E, ARG103D, ARG103E, ARG128E, ARG154E, ARG157E, ARG55D, ARG71D, ARG84E, ASN114E, ASN120E, ASN72D, ASP107D, ASP107E, ASP127E, ASP137E, ASP91D, ASP91E, ASP95D, ASP95E, CYS94D, CYS94E, GLN124E, GLN141E, GLN67D, GLN86D, GLN99D, GLN99E, GLU136E, GLU155E, GLU61D, GLU68D, GLY100D, GLY100E, GLY115E, GLY58D, GLY85D, HIS73D, HIS89D, ILE112E, ILE60D, ILE62D, ILE83E, LEU101D, LEU101E, LEU106E, LEU117E, LEU147E, LEU153E, LEU156E, LEU57D, LEU69D, LYS138E, PHE90D, PHE90E, PRO111E, PRO63D, PRO88D, SER105D, SER105E, SER108E, SER109E, THR102D, THR102E, THR110E, THR118E, THR119E, THR121E, THR143E, THR149E, THR152E, THR52D, THR87D, THR98D, THR98E, TRP27D, TYR92D, TYR92E, VAL104D, VAL104E, VAL116E, VAL144E, VAL23D, VAL53D, VAL54D, VAL56D, VAL64D, VAL65D, VAL82E, VAL93D, VAL93E, VAL97D, VAL97E
• D-H: ALA70D, ARG71D, ARG71H, ASN72D, ASN72H, GLN67D, GLN67H, GLU68D, GLU68H, LEU69H, VAL64D, VAL64H
• D-I: ALA150D, ALA150I, ALA158D, ALA158I, ALA21D, ALA21I, ALA70D, ALA70I, ALA75D, ARG154D, ARG154I, ARG157D, ARG157I, ARG19D, ARG19I, ARG40I, ARG71D, ARG71I, ASN72D, ASN72I, ASP107D, ASP50D, ASP50I, ASP74D, ASP74I, GLN67D, GLU155D, GLU155I, GLU68D, GLU68I, GLY17D, GLY17I, HIS159D, HIS159I, HIS73D, HIS73I, ILE22D, ILE22I, LEU106I, LEU151D, LEU151I, LEU153D, LEU153I, LEU156D, LEU156I, LEU20D, LEU20I, LEU69D, LEU69I, PRO51D, PRO51I, SER108D, SER108I, SER109D, SER109I, SER160D, SER160I, SER16I, THR110I, THR52D, THR52I, VAL18D, VAL18I, VAL53D, VAL53I, VAL54D, VAL54I, VAL65D, VAL65I
• D-J: ALA158D, ALA158J, ARG157D, ARG157J, GLU155D, GLU155J, HIS159D, HIS159J, LEU153D, LEU153J, LEU156D, LEU156J, SER160D, SER160J
• E-G: ARG71E, ARG71G, ASN72E, ASN72G, GLN67E, GLN67G, GLU68E, GLU68G, LEU69E, LEU69G, VAL64E, VAL64G
• E-H: ALA150E, ALA150H, ALA158E, ALA158H, ALA21E, ALA21H, ALA70E, ALA70H, ARG154E, ARG154H, ARG157E, ARG157H, ARG19E, ARG19H, ARG40E, ARG71E, ARG71H, ASN72E, ASN72H, ASP107E, ASP107H, ASP50E, ASP50H, ASP74E, ASP74H, GLU155E, GLU155H, GLU68E, GLU68H, GLY17E, GLY17H, HIS159E, HIS159H, HIS73E, HIS73H, ILE22E, LEU106E, LEU106H, LEU151E, LEU151H, LEU153E, LEU153H, LEU156E, LEU156H, LEU20E, LEU69E, LEU69H, PRO51E, PRO51H, SER108E, SER108H, SER109E, SER109H, SER160E, SER160H, SER16E, SER16H, THR110E, THR110H, THR52E, THR52H, VAL18E, VAL18H, VAL53E, VAL53H, VAL54E, VAL54H, VAL65E, VAL65H
• E-I: ALA158E, ALA158I, ARG157E, ARG157I, GLU155E, GLU155I, HIS159E, HIS159I, LEU153E, LEU153I, LEU156E, LEU156I, SER160E, SER160I, THR152E
• F-G: ALA113G, ALA125G, ALA140G, ALA142G, ALA145G, ALA146G, ALA148G, ALA150G, ALA158G, ALA21F, ALA66F, ALA70F, ALA96F, ALA96G, ARG103F, ARG103G, ARG128G, ARG154G, ARG157G, ARG55F, ARG71F, ARG84G, ASN114G, ASN120G, ASN72F, ASP107F, ASP107G, ASP127G, ASP137G, ASP91F, ASP91G, ASP95F, ASP95G, CYS94F, CYS94G, GLN124G, GLN141G, GLN67F, GLN86F, GLN99F, GLN99G, GLU136G, GLU155G, GLU61F, GLU68F, GLY100F, GLY100G, GLY115G, GLY58F, GLY85F, HIS73F, HIS89F, ILE112G, ILE60F, ILE62F, ILE83G, LEU101F, LEU101G, LEU106G, LEU117G, LEU147G, LEU153G, LEU156G, LEU57F, LEU69F, LYS138G, PHE90F, PHE90G, PRO111G, PRO63F, PRO88F, SER105F, SER105G, SER108G, SER109G, THR102F, THR102G, THR110G, THR118G, THR119G, THR121G, THR143G, THR149G, THR152G, THR52F, THR87F, THR98F, THR98G, TRP27F, TYR92F, TYR92G, VAL104F, VAL104G, VAL116G, VAL144G, VAL23F, VAL53F, VAL54F, VAL56F, VAL64F, VAL65F, VAL82G, VAL93F, VAL93G, VAL97F, VAL97G
• F-H: ARG103F, GLN99F, GLN99H, LEU106H
• F-I: ARG103I, GLN99F, GLN99I, LEU106F, THR102F
• F-J: ALA113F, ALA125F, ALA140F, ALA142F, ALA145F, ALA146F, ALA148F, ALA150F, ALA158F, ALA21J, ALA66J, ALA70J, ALA96F, ALA96J, ARG103F, ARG103J, ARG128F, ARG154F, ARG157F, ARG55J, ARG71J, ARG84F, ASN114F, ASN120F, ASN72J, ASP107F, ASP107J, ASP127F, ASP137F, ASP74F, ASP91F, ASP91J, ASP95F, ASP95J, CYS94F, CYS94J, GLN124F, GLN141F, GLN67J, GLN86J, GLN99F, GLN99J, GLU136F, GLU155F, GLU61J, GLU68J, GLY100F, GLY100J, GLY115F, GLY58J, GLY85J, HIS73J, HIS89F, HIS89J, ILE112F, ILE60J, ILE62J, ILE83F, LEU101F, LEU101J, LEU106F, LEU117F, LEU147F, LEU153F, LEU156F, LEU57J, LEU69J, LYS138F, PHE90F, PHE90J, PRO111F, PRO63J, PRO88J, SER105F, SER105J, SER108F, SER109F, THR102F, THR102J, THR110F, THR118F, THR119F, THR121F, THR143F, THR149F, THR152F, THR52J, THR87J, THR98F, THR98J, TRP27J, TYR92F, TYR92J, VAL104F, VAL104J, VAL116F, VAL144F, VAL23J, VAL53J, VAL54J, VAL56J, VAL64J, VAL65J, VAL82F, VAL93F, VAL93J, VAL97F, VAL97J
• G-H: ALA113H, ALA125H, ALA140H, ALA142H, ALA145H, ALA146H, ALA148H, ALA150H, ALA158H, ALA21G, ALA66G, ALA96G, ALA96H, ARG103G, ARG103H, ARG128H, ARG154H, ARG157H, ARG55G, ARG71G, ARG84H, ASN114H, ASN120H, ASP107G, ASP107H, ASP137H, ASP91G, ASP91H, ASP95G, ASP95H, CYS94G, CYS94H, GLN124H, GLN141H, GLN67G, GLN86G, GLN99G, GLN99H, GLU136H, GLU155H, GLU61G, GLU68G, GLY100G, GLY100H, GLY115H, GLY58G, GLY85G, HIS73G, HIS89G, ILE112H, ILE60G, ILE62G, ILE83H, LEU101G, LEU101H, LEU106H, LEU117H, LEU147H, LEU153H, LEU156H, LEU57G, LEU69G, LYS138H, PHE90G, PHE90H, PRO111H, PRO63G, PRO88G, SER105G, SER105H, SER108H, SER109H, THR102G, THR102H, THR110H, THR118H, THR119H, THR121H, THR143H, THR149H, THR152H, THR52G, THR87G, THR98G, THR98H, TRP27G, TYR92G, TYR92H, VAL104G, VAL104H, VAL116H, VAL144H, VAL23G, VAL53G, VAL54G, VAL56G, VAL64G, VAL65G, VAL82H, VAL93G, VAL93H, VAL97G, VAL97H
• G-I: ARG103G, GLN99G, GLN99I, LEU106I, THR102I
• G-J: ARG103J, GLN99G, GLN99J, LEU106G, THR102G
• H-I: ALA113I, ALA125I, ALA140I, ALA142I, ALA145I, ALA146I, ALA148I, ALA150I, ALA158I, ALA21H, ALA66H, ALA70H, ALA96H, ALA96I, ARG103H, ARG103I, ARG128I, ARG154I, ARG157I, ARG55H, ARG71H, ARG84I, ASN114I, ASN120I, ASN72H, ASP107H, ASP107I, ASP127I, ASP137I, ASP91H, ASP91I, ASP95H, ASP95I, CYS94H, CYS94I, GLN124I, GLN141I, GLN67H, GLN86H, GLN99H, GLN99I, GLU136I, GLU155I, GLU61H, GLU68H, GLY100H, GLY100I, GLY115I, GLY58H, GLY85H, HIS73H, HIS89H, ILE112I, ILE60H, ILE62H, LEU101H, LEU101I, LEU106I, LEU117I, LEU147I, LEU153I, LEU156I, LEU57H, LEU69H, LYS138I, PHE90H, PHE90I, PRO111I, PRO63H, PRO88H, SER105H, SER105I, SER108I, SER109I, THR102H, THR102I, THR110I, THR118I, THR119I, THR121I, THR143I, THR149I, THR152I, THR52H, THR87H, THR98H, THR98I, TRP27H, TYR92H, TYR92I, VAL104H, VAL104I, VAL116I, VAL144I, VAL23H, VAL53H, VAL54H, VAL56H, VAL64H, VAL65H, VAL82I, VAL93H, VAL93I, VAL97H, VAL97I
• H-J: ARG103H, GLN99H, GLN99J, LEU106J
• I-J: ALA113J, ALA125J, ALA140J, ALA142J, ALA145J, ALA146J, ALA148J, ALA150J, ALA158J, ALA66I, ALA96I, ALA96J, ARG103I, ARG103J, ARG128J, ARG154J, ARG157J, ARG55I, ARG71I, ARG84I, ARG84J, ASN114J, ASN120J, ASP107I, ASP107J, ASP127J, ASP91I, ASP91J, ASP95I, ASP95J, CYS94I, CYS94J, GLN124J, GLN141J, GLN67I, GLN86I, GLN99I, GLN99J, GLU136J, GLU155J, GLU61I, GLU68I, GLY100I, GLY100J, GLY115J, GLY58I, GLY85I, HIS73I, HIS89I, HIS89J, ILE112J, ILE60I, ILE62I, ILE83J, LEU101I, LEU101J, LEU106J, LEU117J, LEU147J, LEU153J, LEU156J, LEU57I, LEU69I, LYS138J, PHE90I, PHE90J, PRO111J, PRO63I, PRO88I, PRO88J, SER105I, SER105J, SER108J, SER109J, THR102I, THR102J, THR110J, THR118J, THR119J, THR121J, THR143J, THR149J, THR152J, THR52I, THR87I, THR98I, THR98J, TRP27I, TYR92I, TYR92J, VAL104I, VAL104J, VAL116J, VAL144J, VAL23I, VAL53I, VAL54I, VAL56I, VAL64I, VAL65I, VAL82J, VAL93I, VAL93J, VAL97I, VAL97J