2C91

mouse succinic semialdehyde reductase, akr7a5

• Total interactions analyzed: 45
• Total true interactions: 10
• Strongest Interaction:
  • Chains: I-J
  • Int. Res.: 94
  • Norm. En. per Res.: -3.1968
• Hub Node: C(3)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-F	-5.4838	-49.8898	-59.9313	-115.3049	61	2	4	3696	2	9	18
B-F	-42.7995	3.563	-221.263	-260.4995	103	13	0	7983	1	51	43
C-D	-9.3819	-7.905	-249.849	-267.1358	94	5	2	8595	3	36	32
C-G	-18.039	-48.0789	-76.6973	-142.8152	60	3	4	3562	3	9	18
C-J	0.0	11.0006	-0.5493	10.4513	12	0	0	137	0	6	8
D-E	-52.3575	4.8215	-228.099	-275.635	102	9	0	7912	1	53	44
E-F	-11.2541	-9.0922	-249.078	-269.4243	94	5	2	8603	3	37	32
G-H	-5.044	-6.6505	-256.918	-268.6125	94	1	2	8581	2	36	33
G-J	-61.0807	3.4192	-215.548	-273.2095	104	16	0	7918	1	51	44
I-J	-41.1226	-13.7817	-245.597	-300.5013	94	6	2	8421	4	32	31

Interface residues

• A-F: ALA21A, ALA23A, ALA256F, ALA25A, ALA25F, ALA26A, ALA26F, ALA296F, ALA297F, ALA30A, ALA30F, ARG258F, ARG29A, ARG29F, ARG34F, ASN255F, ASN294F, ASN52A, ASP20A, ASP65A, CYS100A, CYS66A, GLN290F, GLN293F, GLN49A, GLN99A, GLU289F, GLU292F, GLU299F, GLU300F, GLU33F, GLY35F, GLY55A, GLY56A, GLY58A, GLY60A, GLY62A, GLY64A, HIS36F, ILE53A, LEU288A, LEU288F, LEU291F, LEU295F, LEU32F, LEU54A, LEU57A, LEU59A, LEU98A, LYS96A, MET19A, PHE31F, PRO101A, SER22A, SER24A, SER27A, SER27F, SER63A, THR254F, VAL28A, VAL28F
• B-F: ALA110B, ALA110F, ALA225B, ALA225F, ALA42B, ALA42F, ARG17B, ARG17F, ARG18B, ARG18F, ARG229B, ARG229F, ARG327B, ARG327F, ARG88B, ARG88F, ARG97B, ARG97F, ASN222B, ASN222F, ASN223B, ASN223F, ASN230B, ASN230F, ASN52B, ASN52F, ASN75B, ASN75F, ASP209B, ASP209F, ASP211B, ASP211F, ASP47B, ASP47F, ASP85B, ASP85F, CYS46B, CYS46F, GLN214B, GLN214F, GLN49B, GLN49F, GLN90B, GLN90F, GLU14F, GLU226B, GLU226F, GLU51B, GLU51F, GLU78B, GLU78F, GLU92B, GLU92F, GLY16B, GLY16F, GLY212B, GLY212F, GLY221B, GLY221F, GLY48B, GLY48F, GLY79B, GLY79F, ILE87B, ILE87F, LYS210B, LYS210F, LYS213B, LYS213F, LYS80B, LYS80F, LYS96B, LYS96F, MET44B, MET44F, PHE220B, PHE220F, PHE43B, PHE43F, PRO215B, PRO215F, PRO76B, PRO76F, SER114B, SER114F, SER50B, SER50F, SER86B, SER86F, SER89B, SER89F, THR227B, THR227F, THR93B, THR93F, TRP224B, TRP224F, TRP77B, TRP77F, TYR45B, TYR45F, VAL216B, VAL216F
• C-D: ALA142C, ALA142D, ALA147C, ALA147D, ALA177C, ALA177D, ALA319C, ALA319D, ARG184C, ARG184D, ASN156C, ASN156D, ASN316C, ASN316D, ASN324C, ASN324D, ASP312C, ASP312D, CYS150C, CYS150D, CYS153C, CYS153D, CYS182C, CYS182D, CYS322C, CYS322D, GLN174C, GLN174D, GLN313C, GLN313D, GLU118C, GLU118D, GLU145C, GLU145D, GLU148C, GLU148D, GLU176C, GLU176D, GLU178C, GLU178D, GLU321C, GLU321D, HIS113C, HIS113D, HIS185C, HIS185D, HIS236C, HIS236D, HIS320C, HIS320D, ILE149C, ILE149D, LEU152C, LEU152D, LEU179C, LEU179D, LEU180C, LEU180D, LEU183C, LEU183D, LYS154C, LYS154D, MET317C, MET317D, PHE186C, PHE186D, PHE326C, PHE326D, PRO116C, PRO116D, PRO181C, PRO181D, SER143C, SER143D, SER155C, SER155D, THR151C, THR151D, TRP144C, TRP144D, TRP315C, TRP315D, TYR141C, TYR141D, TYR325C, TYR325D, VAL117C, VAL117D, VAL146C, VAL146D, VAL175C, VAL175D, VAL318C, VAL318D
• C-G: ALA21G, ALA23G, ALA256C, ALA25C, ALA25G, ALA26C, ALA26G, ALA296C, ALA297C, ALA30C, ALA30G, ARG258C, ARG29C, ARG29G, ARG34C, ASN255C, ASN294C, ASN52G, ASP20G, ASP65G, CYS100G, CYS66G, GLN290C, GLN293C, GLN49G, GLN99G, GLU289C, GLU292C, GLU299C, GLU300C, GLU33C, GLY35C, GLY55G, GLY56G, GLY58G, GLY60G, GLY62G, GLY64G, ILE53G, LEU288C, LEU288G, LEU291C, LEU295C, LEU32C, LEU54G, LEU57G, LEU59G, LEU98G, LYS96G, MET19G, PHE31C, PRO101G, SER22G, SER24G, SER27C, SER27G, SER63G, THR254C, VAL28C, VAL28G
• C-J: ALA21C, ASP20C, ASP20J, GLU289C, GLY212J, LYS206J, LYS213C, LYS213J, PRO215C, SER22C, VAL216C, VAL216J
• D-E: ALA110D, ALA110E, ALA225D, ALA225E, ALA42D, ALA42E, ARG17D, ARG17E, ARG229D, ARG229E, ARG327D, ARG327E, ARG88D, ARG88E, ARG97D, ARG97E, ASN222D, ASN222E, ASN223D, ASN223E, ASN230D, ASN230E, ASN52D, ASN52E, ASN75D, ASN75E, ASP209D, ASP209E, ASP211D, ASP211E, ASP47D, ASP47E, ASP85D, ASP85E, CYS46D, CYS46E, GLN214D, GLN214E, GLN49D, GLN49E, GLN90D, GLN90E, GLU226D, GLU226E, GLU51D, GLU51E, GLU78D, GLU78E, GLU92D, GLU92E, GLY212D, GLY212E, GLY221D, GLY221E, GLY48D, GLY48E, GLY79D, GLY79E, HIS113D, HIS113E, ILE87D, ILE87E, LYS210D, LYS210E, LYS213D, LYS213E, LYS80D, LYS80E, LYS96D, LYS96E, MET44D, MET44E, PHE220D, PHE220E, PHE43D, PHE43E, PRO215D, PRO215E, PRO76D, PRO76E, SER114D, SER114E, SER50D, SER50E, SER86D, SER86E, SER89D, SER89E, SER94D, SER94E, THR227D, THR227E, THR93D, THR93E, TRP224D, TRP224E, TRP77D, TRP77E, TYR45D, TYR45E, VAL216D, VAL216E
• E-F: ALA142E, ALA142F, ALA147E, ALA147F, ALA177E, ALA177F, ALA319E, ALA319F, ARG184E, ARG184F, ASN156E, ASN156F, ASN316E, ASN316F, ASN324E, ASN324F, ASP312E, ASP312F, CYS150E, CYS150F, CYS153E, CYS153F, CYS182E, CYS182F, CYS322E, CYS322F, GLN174E, GLN174F, GLN313E, GLN313F, GLU118E, GLU118F, GLU145E, GLU145F, GLU148E, GLU148F, GLU176E, GLU176F, GLU178E, GLU178F, GLU321E, GLU321F, HIS113E, HIS113F, HIS185E, HIS185F, HIS236E, HIS236F, HIS320E, HIS320F, ILE149E, ILE149F, LEU152E, LEU152F, LEU179E, LEU179F, LEU180E, LEU180F, LEU183E, LEU183F, LYS154E, LYS154F, MET317E, MET317F, PHE186E, PHE186F, PHE326E, PHE326F, PRO116E, PRO116F, PRO181E, PRO181F, SER143E, SER143F, SER155E, SER155F, THR151E, THR151F, TRP144E, TRP144F, TRP315E, TRP315F, TYR141E, TYR141F, TYR325E, TYR325F, VAL117E, VAL117F, VAL146E, VAL146F, VAL175E, VAL175F, VAL318E, VAL318F
• G-H: ALA142G, ALA142H, ALA147G, ALA147H, ALA177G, ALA177H, ALA319G, ALA319H, ARG184G, ARG184H, ASN156G, ASN156H, ASN316G, ASN316H, ASN324G, ASN324H, ASP312G, ASP312H, CYS150G, CYS150H, CYS153G, CYS153H, CYS182G, CYS182H, CYS322G, CYS322H, GLN174G, GLN174H, GLN313G, GLN313H, GLU118G, GLU118H, GLU145G, GLU145H, GLU148G, GLU148H, GLU176G, GLU176H, GLU178G, GLU178H, GLU321G, GLU321H, HIS113G, HIS113H, HIS185G, HIS185H, HIS236G, HIS236H, HIS320G, HIS320H, ILE149G, ILE149H, LEU152G, LEU152H, LEU179G, LEU179H, LEU180G, LEU180H, LEU183G, LEU183H, LYS154G, LYS154H, MET317G, MET317H, PHE186G, PHE186H, PHE326G, PHE326H, PRO116G, PRO116H, PRO181G, PRO181H, SER143G, SER143H, SER155G, SER155H, THR151G, THR151H, TRP144G, TRP144H, TRP315G, TRP315H, TYR141G, TYR141H, TYR325G, TYR325H, VAL117G, VAL117H, VAL146G, VAL146H, VAL175G, VAL175H, VAL318G, VAL318H
• G-J: ALA110G, ALA110J, ALA225G, ALA225J, ALA42G, ALA42J, ARG17G, ARG17J, ARG229G, ARG229J, ARG231G, ARG231J, ARG327G, ARG327J, ARG88G, ARG88J, ARG97G, ARG97J, ASN222G, ASN222J, ASN223G, ASN223J, ASN230G, ASN230J, ASN52G, ASN52J, ASN75G, ASN75J, ASP209G, ASP209J, ASP211G, ASP47G, ASP47J, ASP85G, ASP85J, CYS46G, CYS46J, GLN214G, GLN214J, GLN49G, GLN49J, GLN90G, GLN90J, GLU226G, GLU226J, GLU51G, GLU51J, GLU78G, GLU78J, GLU92G, GLU92J, GLY212G, GLY212J, GLY221G, GLY221J, GLY48G, GLY48J, GLY79G, GLY79J, HIS113G, HIS113J, ILE87G, ILE87J, LYS210G, LYS210J, LYS213G, LYS213J, LYS80G, LYS80J, LYS83G, LYS96G, LYS96J, MET44G, MET44J, PHE220G, PHE220J, PHE43G, PHE43J, PRO215G, PRO215J, PRO76G, PRO76J, SER114G, SER114J, SER50G, SER50J, SER81J, SER86G, SER86J, SER89G, SER89J, SER94J, THR227G, THR227J, THR93G, THR93J, TRP224G, TRP224J, TRP77G, TRP77J, TYR45G, TYR45J, VAL216G, VAL216J
• I-J: ALA142I, ALA142J, ALA147I, ALA147J, ALA177I, ALA177J, ALA319I, ALA319J, ARG184I, ARG184J, ASN156I, ASN156J, ASN316I, ASN316J, ASN324I, ASN324J, ASP312I, ASP312J, CYS150I, CYS150J, CYS153I, CYS153J, CYS182I, CYS182J, CYS322I, CYS322J, GLN174I, GLN174J, GLN313I, GLN313J, GLU118I, GLU118J, GLU145I, GLU145J, GLU148I, GLU148J, GLU176I, GLU176J, GLU178I, GLU178J, GLU321I, GLU321J, HIS113I, HIS113J, HIS185I, HIS185J, HIS236I, HIS236J, HIS320I, HIS320J, ILE149I, ILE149J, LEU152I, LEU152J, LEU179I, LEU179J, LEU180I, LEU180J, LEU183I, LEU183J, LYS154I, LYS154J, MET317I, MET317J, PHE186I, PHE186J, PHE326I, PHE326J, PRO116I, PRO116J, PRO181I, PRO181J, SER143I, SER143J, SER155I, SER155J, THR151I, THR151J, TRP144I, TRP144J, TRP315I, TRP315J, TYR141I, TYR141J, TYR325I, TYR325J, VAL117I, VAL117J, VAL146I, VAL146J, VAL175I, VAL175J, VAL318I, VAL318J