2C7D

fitted coordinates for groel-adp7-groes cryo-em complex (emd-1181)

• Total interactions analyzed: 210
• Total true interactions: 47
• Strongest Interaction:
  • Chains: A-H
  • Int. Res.: 23
  • Norm. En. per Res.: -3.4266
• Hub Node: B(6)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-148.9371	8.8241	-418.609	-558.722	196	17	11	18605	1	60	78
A-C	0.0	0.0	-0.0023	-0.0023	2	0	0	2	0	0	0
A-G	-146.5931	1.5561	-420.136	-565.1731	185	20	13	18257	2	66	85
A-H	-23.5208	-7.3043	-47.9864	-78.8115	23	2	1	1746	1	8	6
A-O	-25.4263	0.0			5
B-C	-152.2788	-2.8716	-420.298	-575.4484	194	21	14	18613	3	59	81
B-D	0.0	0.0	-0.0003	-0.0003	2	0	0	1	0	0	0
B-G	0.0	0.0	-0.0038	-0.0038	2	0	0	3	0	0	0
B-H	0.0	0.0	-29.2556	-29.2556	32	0	5	1407	0	7	6
B-I	-3.5272	2.6437	-41.7515	-42.635	22	2	1	1587	0	7	6
B-P	-25.647	3.8439			7
C-D	-142.3983	-3.1009	-457.784	-603.2832	191	22	14	19718	3	66	77
C-E	0.0	0.0	-0.0348	-0.0348	2	0	0	14	0	0	0
C-I	0.0	0.0	-20.6757	-20.6757	29	0	3	1101	0	8	7
C-J	0.0	3.8001	-42.7418	-38.9417	22	2	1	1663	0	9	6
C-Q	-26.5889	0.0			4
D-E	-150.2554	-1.9352	-418.44	-570.6306	179	22	12	17742	3	59	72
D-F	0.0	0.0	-0.0003	-0.0003	2	0	0	1	0	0	0
D-J	0.0	0.0	-37.2871	-37.2871	40	0	5	1671	0	14	8
D-K	-10.47	1.4489	-46.1983	-55.2195	22	2	1	1636	0	8	7
D-R	-25.5949	0.0			5
E-F	-176.6318	-6.0076	-464.394	-647.0334	192	20	13	19359	2	68	78
E-G	0.0	0.0	-0.0784	-0.0784	3	0	0	21	0	0	0
E-K	0.0	0.0	-24.2903	-24.2903	31	0	4	1180	0	12	7
E-L	0.0	2.4287	-51.8787	-49.45	23	4	1	1796	0	8	6
E-S	-24.5682	0.0			5
F-G	-158.6597	6.2576	-443.266	-595.6681	187	22	14	18788	2	58	80
F-L	0.0	0.0	-27.7229	-27.7229	33	0	5	1392	0	14	8
F-M	0.0	3.7493	0.0	3.7493	2	0	0	0	0	0	0
F-T	-17.4408	0.0			3
G-M	0.0	0.0	-27.3001	-27.3001	29	0	3	1223	0	8	6
G-N	-7.6396	5.1631			4
G-U	-35.3417	0.0			5
H-I	-7.8591	22.196	-98.672	-84.3351	97	6	3	5095	0	42	51
H-N	-37.5944	64.9476			17
I-J	-16.8937	42.7365	-102.989	-77.1462	87	2	2	4733	0	41	44
J-K	-17.0853	29.472	-122.967	-110.5802	111	3	3	5848	0	48	52
K-L	-22.6497	22.8135	-105.339	-105.1752	108	4	2	5712	0	42	49
L-M	-44.7776	29.8267	-109.053	-124.0039	99	3	3	5852	1	47	45
M-N	-19.9414	45.8886			14
O-P	-84.8507	-14.896			18
O-U	-91.6018	-18.6793			17
P-Q	-83.1761	-4.6047			19
Q-R	-79.2192	3.4179			18
R-S	-83.8305	-9.9747			18
S-T	-75.9739	-19.5435			18
T-U	-86.9901	-1.1238			16

Interface residues

• A-B: ALA12B, ALA152A, ALA212A, ALA24A, ALA260A, ALA26A, ALA2B, ALA356B, ALA383A, ALA384A, ALA3B, ALA46A, ALA480A, ALA481A, ALA507B, ALA508B, ALA511B, ALA57A, ALA71B, ALA81B, ALA84B, ARG118B, ARG13B, ARG268A, ARG345B, ARG36A, ARG395A, ARG501B, ARG58A, ASN112B, ASN153A, ASN21A, ASN37A, ASN433B, ASN457A, ASN68A, ASN68B, ASP115B, ASP121B, ASP155A, ASP224B, ASP25A, ASP283B, ASP328A, ASP359B, ASP361B, ASP41A, ASP435B, ASP523B, ASP5B, ASP64A, ASP83B, CYS458A, CYS519B, GLN184A, GLN290B, GLN348B, GLN351B, GLN352B, GLN432B, GLN436B, GLN505B, GLN72A, GLN72B, GLU156A, GLU209A, GLU257A, GLU303B, GLU304B, GLU308B, GLU355B, GLU386A, GLU388A, GLU391A, GLU409B, GLU460A, GLU483A, GLU518B, GLU59A, GLU61A, GLU61B, GLU63A, GLU76B, GLY110B, GLY180A, GLY182A, GLY211A, GLY256A, GLY306B, GLY32A, GLY344B, GLY35A, GLY459A, GLY45A, GLY512B, GLY70B, GLY9B, ILE205A, ILE301B, ILE305B, ILE49A, ILE515B, ILE60A, LEU183A, LEU200A, LEU23A, LEU259A, LEU262A, LEU365B, LEU40A, LEU504B, LEU513B, LEU524B, LEU62A, LYS117B, LYS132B, LYS207A, LYS286B, LYS28A, LYS327A, LYS34A, LYS364B, LYS390A, LYS392A, LYS42A, LYS498B, LYS4B, LYS51A, LYS65A, LYS65B, LYS75A, LYS75B, LYS7B, LYS80B, MET111B, MET114B, MET16B, MET267A, MET307B, MET389A, MET514B, MET520B, MET69B, MET73B, PHE44A, PHE66B, PHE8B, PRO113B, PRO202A, PRO208A, PRO33A, PRO47A, PRO525B, SER151A, SER154A, SER201A, SER302B, SER358B, SER43A, SER502B, SER509B, SER55A, THR125B, THR181A, THR210A, THR261A, THR299B, THR30A, THR357B, THR385A, THR482A, THR48A, THR50A, THR516B, THR517B, THR522B, TYR203A, TYR506B, VAL107B, VAL124B, VAL128B, VAL22A, VAL263A, VAL264A, VAL27A, VAL29A, VAL300B, VAL387A, VAL38A, VAL39A, VAL510B, VAL521B, VAL56A, VAL6B, VAL74B, VAL77B
• A-C: ALA2C, SER43A
• A-G: ALA12A, ALA152G, ALA212G, ALA24G, ALA260G, ALA26G, ALA2A, ALA347A, ALA356A, ALA383G, ALA384G, ALA3A, ALA46G, ALA480G, ALA481G, ALA507A, ALA508A, ALA511A, ALA57G, ALA71A, ALA84A, ARG118A, ARG13A, ARG268G, ARG345A, ARG36G, ARG395G, ARG501A, ARG58G, ASN112A, ASN153G, ASN21G, ASN37G, ASN433A, ASN457G, ASN68A, ASN68G, ASP115A, ASP121A, ASP155G, ASP224A, ASP25G, ASP283A, ASP41G, ASP435A, ASP523A, ASP5A, ASP64A, ASP64G, ASP83A, CYS458G, CYS519A, GLN184G, GLN290A, GLN348A, GLN351A, GLN352A, GLN432A, GLN436A, GLN505A, GLN72A, GLU156G, GLU209G, GLU255G, GLU257G, GLU303A, GLU304A, GLU354A, GLU355A, GLU386G, GLU388G, GLU391G, GLU483G, GLU518A, GLU59G, GLU61A, GLU61G, GLU63G, GLU76A, GLY110A, GLY211G, GLY256G, GLY306A, GLY32G, GLY344A, GLY35G, GLY459G, GLY45G, GLY512A, GLY70A, GLY9A, ILE205G, ILE301A, ILE305A, ILE349A, ILE49G, ILE515A, ILE60G, LEU183G, LEU200G, LEU23G, LEU259G, LEU40G, LEU513A, LEU524A, LEU62G, LYS117A, LYS132A, LYS207G, LYS286A, LYS28G, LYS311A, LYS327G, LYS34G, LYS364A, LYS390G, LYS392G, LYS42G, LYS4A, LYS51G, LYS65A, LYS65G, LYS75A, LYS75G, LYS7A, LYS80A, MET111A, MET114A, MET16A, MET267G, MET307A, MET389G, MET514A, MET520A, MET69A, MET73A, PHE44G, PHE66A, PHE8A, PRO113A, PRO202G, PRO208G, PRO33G, PRO47G, PRO525A, SER154G, SER201G, SER302A, SER43G, SER502A, SER509A, SER55G, SER79A, THR181G, THR210G, THR261G, THR30G, THR357A, THR385G, THR482G, THR48G, THR50G, THR516A, THR517A, THR522A, TYR203G, TYR506A, VAL107A, VAL124A, VAL128A, VAL22G, VAL263G, VAL264G, VAL27G, VAL29G, VAL300A, VAL387G, VAL38G, VAL39G, VAL510A, VAL521A, VAL56G, VAL6A, VAL74A, VAL77A
• A-H: ALA466A, ALA466H, ARG452A, ARG452H, ASN467A, ASN467H, GLU448H, GLU460A, GLU461A, GLU461H, GLY471H, LYS470A, LYS470H, PRO462A, PRO462H, SER463A, SER463H, THR468A, THR468H, VAL464A, VAL464H, VAL465A, VAL465H
• A-O: ASN265A, GLU238A, ILE25O, LEU27O, VAL26O
• B-C: ALA12C, ALA152B, ALA212B, ALA24B, ALA260B, ALA26B, ALA287C, ALA2C, ALA347C, ALA356C, ALA383B, ALA384B, ALA3C, ALA46B, ALA480B, ALA481B, ALA507C, ALA508C, ALA511C, ALA57B, ALA71B, ALA71C, ALA81C, ALA84C, ARG118C, ARG13C, ARG268B, ARG345C, ARG36B, ARG395B, ARG501C, ARG58B, ASN112C, ASN153B, ASN21B, ASN37B, ASN433C, ASN457B, ASN68B, ASN68C, ASP115C, ASP121C, ASP155B, ASP224C, ASP25B, ASP283C, ASP328B, ASP41B, ASP435C, ASP523C, ASP5C, ASP64B, ASP83C, CYS458B, CYS519C, GLN184B, GLN290C, GLN348C, GLN351C, GLN352C, GLN432C, GLN436C, GLN505C, GLN72B, GLN72C, GLU156B, GLU209B, GLU255B, GLU257B, GLU303C, GLU304C, GLU308C, GLU354C, GLU355C, GLU386B, GLU388B, GLU391B, GLU483B, GLU518C, GLU59B, GLU61B, GLU61C, GLU63B, GLU76C, GLY110C, GLY180B, GLY182B, GLY211B, GLY256B, GLY306C, GLY32B, GLY344C, GLY35B, GLY459B, GLY45B, GLY512C, GLY70C, GLY9C, ILE205B, ILE301C, ILE305C, ILE49B, ILE515C, ILE60B, LEU183B, LEU200B, LEU23B, LEU259B, LEU262B, LEU289C, LEU40B, LEU504C, LEU513C, LEU524C, LEU62B, LEU62C, LYS117C, LYS132C, LYS207B, LYS286C, LYS28B, LYS327B, LYS34B, LYS390B, LYS392B, LYS42B, LYS498C, LYS4C, LYS51B, LYS65B, LYS65C, LYS75B, LYS75C, LYS7C, LYS80C, MET111C, MET114C, MET16C, MET267B, MET307C, MET389B, MET514C, MET520C, MET69C, MET73C, PHE204B, PHE44B, PHE66C, PHE8C, PRO113C, PRO202B, PRO208B, PRO33B, PRO47B, SER154B, SER201B, SER302C, SER43B, SER502C, SER509C, SER55B, SER79C, THR181B, THR210B, THR261B, THR30B, THR357C, THR385B, THR482B, THR48B, THR50B, THR516C, THR517C, THR522C, TYR203B, TYR506C, VAL107C, VAL124C, VAL128C, VAL22B, VAL263B, VAL264B, VAL27B, VAL29B, VAL300C, VAL387B, VAL38B, VAL39B, VAL510C, VAL521C, VAL56B, VAL6C, VAL74C, VAL77C
• B-D: ALA2D, SER43B
• B-G: ALA2B, SER43G
• B-H: ALA106B, ALA106H, ALA108B, ALA108H, ALA109B, ALA109H, ARG18B, ARG445B, ARG445H, ASN10B, ASN10H, ASP435H, GLU102B, GLU102H, GLU434H, GLY110B, GLY110H, LEU104B, LEU104H, LEU17B, LYS105B, LYS105H, MET111B, MET111H, THR101B, VAL107B, VAL107H, VAL14B, VAL14H, VAL438B, VAL438H, VAL442H
• B-I: ALA466B, ALA466I, ARG452B, ARG452I, ASN467B, ASN467I, GLU448I, GLU460B, GLU461B, GLU461I, LYS470B, LYS470I, PRO462B, PRO462I, SER463B, SER463I, THR468B, THR468I, VAL464B, VAL464I, VAL465B, VAL465I
• B-P: ASN265B, GLU18P, GLU238B, GLU257B, ILE25P, LEU27P, VAL26P
• C-D: ALA12D, ALA152C, ALA212C, ALA24C, ALA258C, ALA260C, ALA26C, ALA287D, ALA293D, ALA2D, ALA347D, ALA356D, ALA383C, ALA384C, ALA3D, ALA46C, ALA480C, ALA481C, ALA507D, ALA508D, ALA511D, ALA57C, ALA71D, ALA81D, ALA84D, ARG118D, ARG13D, ARG268C, ARG345D, ARG36C, ARG395C, ARG501D, ARG58C, ASN112D, ASN153C, ASN21C, ASN265C, ASN37C, ASN433D, ASN457C, ASN68C, ASN68D, ASP115D, ASP121D, ASP155C, ASP224D, ASP25C, ASP283D, ASP328C, ASP41C, ASP435D, ASP523D, ASP5D, ASP64C, ASP83D, CYS458C, CYS519D, GLN184C, GLN290D, GLN348D, GLN351D, GLN352D, GLN432D, GLN436D, GLN505D, GLN72D, GLU156C, GLU209C, GLU257C, GLU303D, GLU304D, GLU308D, GLU355D, GLU386C, GLU388C, GLU391C, GLU483C, GLU518D, GLU59C, GLU61C, GLU61D, GLU63C, GLU76D, GLY110D, GLY211C, GLY256C, GLY306D, GLY32C, GLY344D, GLY35C, GLY459C, GLY45C, GLY512D, GLY70D, GLY9D, ILE205C, ILE301D, ILE305D, ILE49C, ILE515D, ILE60C, LEU183C, LEU200C, LEU23C, LEU259C, LEU262C, LEU289D, LEU40C, LEU504D, LEU513D, LEU524D, LEU62C, LYS117D, LYS132D, LYS207C, LYS286D, LYS28C, LYS327C, LYS34C, LYS390C, LYS392C, LYS42C, LYS498D, LYS4D, LYS51C, LYS65C, LYS65D, LYS75C, LYS75D, LYS7D, LYS80D, MET111D, MET114D, MET16D, MET267C, MET307D, MET389C, MET514D, MET520D, MET69D, MET73D, PHE204C, PHE44C, PHE66D, PHE8D, PRO113D, PRO202C, PRO208C, PRO33C, PRO47C, SER154C, SER201C, SER302D, SER358D, SER43C, SER502D, SER509D, SER55C, THR181C, THR210C, THR261C, THR299D, THR30C, THR357D, THR385C, THR482C, THR48C, THR50C, THR516D, THR517D, THR522D, TYR203C, TYR506D, VAL107D, VAL124D, VAL128D, VAL22C, VAL263C, VAL264C, VAL27C, VAL29C, VAL300D, VAL387C, VAL38C, VAL39C, VAL510D, VAL521D, VAL56C, VAL6D, VAL74D, VAL77D
• C-E: ALA2E, SER43C
• C-I: ALA106C, ALA106I, ALA108C, ALA108I, ALA109C, ALA109I, ARG18C, ARG445C, ARG445I, ASN10C, ASN10I, GLU102C, GLU434I, GLY110C, GLY110I, LEU104C, LEU104I, LYS105C, LYS105I, LYS15C, MET111C, MET111I, THR101C, VAL107C, VAL107I, VAL14C, VAL14I, VAL438C, VAL438I
• C-J: ALA466C, ALA466J, ARG452C, ARG452J, ASN467C, ASN467J, GLU448J, GLU460C, GLU461C, GLU461J, LYS470J, PRO462C, PRO462J, SER463C, SER463J, THR468C, THR468J, VAL455C, VAL464C, VAL464J, VAL465C, VAL465J
• C-Q: GLU238C, GLY24Q, ILE25Q, VAL26Q
• D-E: ALA12E, ALA152D, ALA24D, ALA260D, ALA26D, ALA2E, ALA383D, ALA384D, ALA3E, ALA46D, ALA480D, ALA481D, ALA507E, ALA508E, ALA511E, ALA57D, ALA71E, ALA78E, ALA81E, ALA84E, ARG118E, ARG13E, ARG268D, ARG345E, ARG36D, ARG395D, ARG501E, ARG58D, ASN112E, ASN153D, ASN21D, ASN37D, ASN433E, ASN457D, ASN68D, ASN68E, ASP115E, ASP121E, ASP155D, ASP25D, ASP41D, ASP435E, ASP523E, ASP5E, ASP64D, ASP64E, ASP83E, CYS458D, CYS519E, GLN184D, GLN290E, GLN348E, GLN351E, GLN352E, GLN432E, GLN436E, GLN505E, GLN72E, GLU156D, GLU209D, GLU257D, GLU303E, GLU304E, GLU308E, GLU355E, GLU386D, GLU388D, GLU391D, GLU483D, GLU518E, GLU59D, GLU61D, GLU61E, GLU63D, GLU67E, GLU76E, GLY110E, GLY211D, GLY256D, GLY306E, GLY32D, GLY35D, GLY459D, GLY45D, GLY512E, GLY70E, GLY9E, ILE205D, ILE305E, ILE49D, ILE515E, ILE60D, LEU116E, LEU183D, LEU200D, LEU23D, LEU259D, LEU40D, LEU513E, LEU524E, LEU62D, LEU62E, LYS117E, LYS132E, LYS207D, LYS286E, LYS28D, LYS327D, LYS34D, LYS390D, LYS392D, LYS42D, LYS4E, LYS51D, LYS65D, LYS65E, LYS75D, LYS75E, LYS7E, LYS80E, MET111E, MET114E, MET16E, MET267D, MET307E, MET389D, MET514E, MET520E, MET69E, MET73E, PHE44D, PHE66E, PHE8E, PRO113E, PRO202D, PRO208D, PRO33D, PRO47D, PRO525D, SER154D, SER201D, SER302E, SER43D, SER502E, SER509E, SER55D, SER79E, THR181D, THR210D, THR261D, THR299E, THR30D, THR357E, THR385D, THR482D, THR48D, THR50D, THR516E, THR517E, THR522E, TYR203D, TYR506E, VAL107E, VAL124E, VAL128E, VAL22D, VAL263D, VAL264D, VAL27D, VAL29D, VAL300E, VAL387D, VAL38D, VAL39D, VAL510E, VAL521E, VAL56D, VAL6E, VAL77E
• D-F: ALA2F, SER43D
• D-J: ALA106D, ALA106J, ALA108D, ALA108J, ALA109D, ALA109J, ARG18D, ARG430J, ARG445D, ARG445J, ASN10D, ASN10J, ASN112J, ASP11J, ASP435J, GLU102D, GLU102J, GLU434D, GLU434J, GLY103D, GLY110D, GLY110J, LEU104D, LEU104J, LEU116J, LEU17D, LEU17J, LYS105D, LYS105J, LYS441J, MET111D, MET111J, THR101D, VAL107D, VAL107J, VAL14D, VAL14J, VAL438D, VAL438J, VAL442J
• D-K: ALA466D, ALA466K, ARG452D, ARG452K, ASN467D, ASN467K, GLU448K, GLU460D, GLU461D, GLU461K, LYS470D, LYS470K, PRO462D, PRO462K, SER463D, SER463K, THR468D, THR468K, VAL464D, VAL464K, VAL465D, VAL465K
• D-R: ASN265D, GLU238D, ILE25R, LEU27R, VAL26R
• E-F: ALA12F, ALA152E, ALA212E, ALA24E, ALA260E, ALA26E, ALA287F, ALA2F, ALA347F, ALA383E, ALA384E, ALA3F, ALA46E, ALA480E, ALA481E, ALA507F, ALA508F, ALA511F, ALA57E, ALA71F, ALA78F, ALA81F, ALA84F, ARG118F, ARG13F, ARG268E, ARG345F, ARG36E, ARG395E, ARG501F, ARG58E, ASN112F, ASN153E, ASN21E, ASN326E, ASN37E, ASN433F, ASN457E, ASN68E, ASN68F, ASP115F, ASP121F, ASP155E, ASP224F, ASP25E, ASP283F, ASP361F, ASP41E, ASP435F, ASP523F, ASP5F, ASP64E, ASP64F, ASP83F, CYS458E, CYS519F, GLN184E, GLN290F, GLN348F, GLN351F, GLN352F, GLN432F, GLN505F, GLN72F, GLU156E, GLU209E, GLU257E, GLU303F, GLU304F, GLU354F, GLU355F, GLU386E, GLU388E, GLU391E, GLU409F, GLU483E, GLU518F, GLU59E, GLU61E, GLU61F, GLU63E, GLU67F, GLU76F, GLY110F, GLY180E, GLY182E, GLY211E, GLY256E, GLY306F, GLY32E, GLY344F, GLY35E, GLY459E, GLY45E, GLY512F, GLY70F, GLY9F, ILE205E, ILE305F, ILE349F, ILE49E, ILE515F, ILE60E, LEU183E, LEU200E, LEU23E, LEU259E, LEU40E, LEU513F, LEU524F, LEU62E, LEU62F, LYS117F, LYS132F, LYS207E, LYS286F, LYS28E, LYS327E, LYS34E, LYS364F, LYS380E, LYS390E, LYS392E, LYS42E, LYS4F, LYS51E, LYS65E, LYS65F, LYS75E, LYS75F, LYS7F, LYS80F, MET111F, MET114F, MET16F, MET267E, MET307F, MET389E, MET514F, MET520F, MET69F, MET73F, PHE44E, PHE66F, PHE8F, PRO113F, PRO202E, PRO208E, PRO33E, PRO47E, SER154E, SER201E, SER302F, SER43E, SER502F, SER509F, SER55E, SER79F, THR125F, THR181E, THR210E, THR261E, THR299F, THR30E, THR357F, THR385E, THR482E, THR48E, THR50E, THR516F, THR517F, THR522F, TYR203E, TYR506F, VAL107F, VAL124F, VAL128F, VAL22E, VAL263E, VAL264E, VAL27E, VAL29E, VAL300F, VAL387E, VAL38E, VAL39E, VAL510F, VAL521F, VAL56E, VAL6F, VAL74F, VAL77F
• E-G: ALA2G, ALA3G, SER43E
• E-K: ALA106E, ALA106K, ALA108E, ALA108K, ALA109E, ALA109K, ARG18E, ARG445E, ARG445K, ASN10E, ASN10K, ASP435K, GLU102E, GLU434E, GLU434K, GLY110E, GLY110K, LEU104E, LEU17E, LEU17K, LYS105E, LYS105K, MET111E, MET111K, THR101E, VAL107E, VAL107K, VAL14E, VAL14K, VAL438E, VAL438K
• E-L: ALA466E, ALA466L, ARG452E, ARG452L, ASN467E, ASN467L, GLU448E, GLU448L, GLU460E, GLU461E, GLU461L, LYS470E, LYS470L, PRO462E, PRO462L, SER463E, SER463L, THR468E, THR468L, VAL464E, VAL464L, VAL465E, VAL465L
• E-S: ASN265E, GLU238E, ILE25S, LEU27S, VAL26S
• F-G: ALA12G, ALA152F, ALA212F, ALA24F, ALA260F, ALA26F, ALA287G, ALA2G, ALA347G, ALA356G, ALA383F, ALA384F, ALA3G, ALA46F, ALA480F, ALA481F, ALA507G, ALA508G, ALA511G, ALA57F, ALA71G, ALA81G, ALA84G, ARG118G, ARG13G, ARG268F, ARG345G, ARG36F, ARG395F, ARG501G, ARG58F, ASN112G, ASN153F, ASN21F, ASN37F, ASN433G, ASN457F, ASN68F, ASN68G, ASP115G, ASP121G, ASP155F, ASP224G, ASP25F, ASP283G, ASP328F, ASP41F, ASP435G, ASP523G, ASP5G, ASP64F, ASP64G, ASP83G, CYS458F, CYS519G, GLN184F, GLN290G, GLN348G, GLN351G, GLN352G, GLN432G, GLN436G, GLN505G, GLN72F, GLN72G, GLU156F, GLU209F, GLU257F, GLU303G, GLU304G, GLU355G, GLU386F, GLU388F, GLU391F, GLU483F, GLU518G, GLU59F, GLU61F, GLU61G, GLU63F, GLU76G, GLY110G, GLY211F, GLY306G, GLY32F, GLY344G, GLY35F, GLY459F, GLY45F, GLY512G, GLY70G, GLY9G, ILE205F, ILE301G, ILE305G, ILE49F, ILE515G, ILE60F, LEU183F, LEU200F, LEU23F, LEU259F, LEU40F, LEU504G, LEU513G, LEU524G, LEU62F, LYS117G, LYS207F, LYS286G, LYS28F, LYS311G, LYS327F, LYS34F, LYS390F, LYS392F, LYS42F, LYS498G, LYS4G, LYS51F, LYS65F, LYS65G, LYS75F, LYS75G, LYS7G, LYS80G, MET111G, MET114G, MET16G, MET267F, MET307G, MET389F, MET514G, MET520G, MET69G, MET73G, PHE204F, PHE44F, PHE66G, PHE8G, PRO113G, PRO202F, PRO208F, PRO33F, PRO47F, SER154F, SER201F, SER302G, SER358G, SER43F, SER502G, SER509G, SER55F, THR149F, THR157F, THR181F, THR210F, THR261F, THR30F, THR357G, THR385F, THR482F, THR48F, THR50F, THR516G, THR517G, THR522G, TYR203F, TYR506G, VAL107G, VAL124G, VAL128G, VAL22F, VAL263F, VAL264F, VAL27F, VAL29F, VAL300G, VAL387F, VAL38F, VAL39F, VAL510G, VAL521G, VAL56F, VAL6G, VAL74G, VAL77G
• F-L: ALA106F, ALA106L, ALA108F, ALA108L, ALA109F, ALA109L, ARG18F, ARG430L, ARG445F, ARG445L, ASN10F, ASN10L, ASN112L, ASN437L, ASP11L, ASP435L, GLU102F, GLU434F, GLU434L, GLY110F, GLY110L, LEU104F, LEU17F, LYS105F, LYS105L, MET111F, MET111L, THR101F, VAL107F, VAL14F, VAL14L, VAL438F, VAL438L
• F-M: GLU461F, GLU461M
• F-T: GLU238F, ILE25T, VAL26T
• G-M: ALA106G, ALA106M, ALA108G, ALA108M, ALA109G, ALA109M, ARG18G, ARG445G, ASN10G, ASN10M, ASP11G, ASP11M, GLU102G, GLU434M, GLY110G, GLY110M, LEU104G, LEU104M, LEU17M, LYS105G, LYS105M, LYS15G, MET111G, MET111M, VAL107G, VAL107M, VAL14G, VAL14M, VAL438M
• G-N: ASN467N, GLU461G, GLU461N, SER463G
• G-U: ASN265G, GLU238G, ILE25U, LEU27U, VAL26U
• H-I: ALA241I, ALA243I, ALA26I, ALA384I, ALA3H, ALA46I, ALA480I, ALA481I, ARG118H, ARG18I, ARG197H, ARG231H, ARG36I, ASN112H, ASN21I, ASN229H, ASN37I, ASN433H, ASN457I, ASN68I, ASP115H, ASP25I, ASP328H, ASP41I, ASP523H, ASP5H, ASP64I, CYS458I, CYS519H, GLN432H, GLN436H, GLN72H, GLU216I, GLU255H, GLU257H, GLU386I, GLU460I, GLU461I, GLU483I, GLU518H, GLU59I, GLU61I, GLU63I, GLU67I, GLU76H, GLY182I, GLY19I, GLY244I, GLY35I, GLY459I, GLY512H, ILE49I, ILE515H, ILE60I, LEU23I, LEU259H, LEU40I, LEU456I, LEU513H, LEU524H, LEU62I, LYS117H, LYS242I, LYS245I, LYS272I, LYS327H, LYS34I, LYS4H, LYS51I, LYS65I, LYS7H, MET114H, MET520H, MET69H, MET73H, PHE8H, PRO113H, PRO246I, PRO33I, PRO47I, SER228H, SER43I, THR181I, THR385I, THR482I, THR516H, THR517H, THR522H, TYR478I, VAL22I, VAL29I, VAL38I, VAL39I, VAL455I, VAL521H, VAL56I, VAL6H
• H-N: ALA3N, ASP115N, ASP41H, ASP435N, ASP523N, ASP5N, ASP64H, GLU460H, GLU483H, GLU518N, GLU59H, GLU61H, GLU63H, GLU67H, LYS28H, LYS4N, LYS65N
• I-J: ALA24J, ALA26J, ALA3I, ALA480J, ALA481J, ARG118I, ARG18J, ARG231I, ARG36J, ASN112I, ASN21J, ASN229I, ASN37J, ASN433I, ASN457J, ASN68J, ASP115I, ASP25J, ASP41J, ASP435I, ASP523I, ASP5I, ASP64J, CYS458J, CYS519I, GLN432I, GLN436I, GLN72I, GLU216J, GLU255I, GLU257I, GLU460J, GLU483J, GLU484J, GLU518I, GLU59J, GLU61J, GLU63J, GLU67J, GLY19J, GLY244J, GLY35J, GLY459J, GLY512I, ILE515I, ILE60J, LEU23J, LEU40J, LEU456J, LEU513I, LEU524I, LEU62J, LYS117I, LYS242J, LYS277I, LYS28J, LYS327I, LYS34J, LYS4I, LYS51J, LYS65J, LYS7I, LYS80I, MET114I, MET520I, MET69I, MET73I, PHE8I, PRO113I, PRO33J, PRO47J, SER43J, THR181J, THR385J, THR482J, THR516I, THR517I, THR522I, VAL22J, VAL27J, VAL29J, VAL38J, VAL39J, VAL455J, VAL521I, VAL56J, VAL6I
• J-K: ALA241K, ALA24K, ALA26K, ALA3J, ALA46K, ALA480K, ALA481K, ALA57K, ARG118J, ARG18K, ARG231J, ARG36K, ARG58K, ASN112J, ASN21K, ASN229J, ASN37K, ASN433J, ASN457K, ASN68K, ASP115J, ASP253J, ASP25K, ASP41K, ASP435J, ASP523J, ASP5J, ASP64K, CYS458K, CYS519J, GLN432J, GLN436J, GLN72J, GLU216K, GLU255J, GLU257J, GLU386K, GLU460K, GLU461K, GLU483K, GLU518J, GLU59K, GLU61K, GLU63K, GLU67K, GLU76J, GLY180K, GLY182K, GLY19K, GLY244K, GLY32K, GLY35K, GLY459K, GLY512J, GLY9J, ILE270K, ILE49K, ILE515J, ILE60K, LEU200J, LEU23K, LEU40K, LEU456K, LEU513J, LEU524J, LEU62K, LYS117J, LYS242K, LYS272K, LYS277J, LYS28K, LYS327J, LYS34K, LYS390K, LYS4J, LYS51K, LYS65K, LYS75J, LYS75K, LYS7J, LYS80J, MET111J, MET114J, MET514J, MET520J, MET69J, MET73J, PHE8J, PRO113J, PRO33K, PRO47K, SER228J, SER43K, THR181K, THR385K, THR482K, THR516J, THR517J, THR522J, TYR478K, VAL22K, VAL27K, VAL29K, VAL387K, VAL38K, VAL39K, VAL455K, VAL510J, VAL521J, VAL56K, VAL6J
• K-L: ALA241L, ALA24L, ALA26L, ALA383L, ALA384L, ALA3K, ALA480L, ALA481L, ARG118K, ARG13K, ARG18L, ARG197K, ARG231K, ARG36L, ASN112K, ASN21L, ASN229K, ASN37L, ASN433K, ASN457L, ASN68L, ASP115K, ASP25L, ASP328K, ASP41L, ASP523K, ASP5K, ASP64L, CYS458L, CYS519K, GLN432K, GLN436K, GLN72K, GLN72L, GLN97L, GLU255K, GLU257K, GLU386L, GLU460L, GLU483L, GLU518K, GLU59L, GLU61L, GLU63L, GLU67L, GLU76K, GLY182L, GLY19L, GLY244L, GLY280K, GLY32L, GLY35L, GLY459L, ILE270L, ILE49L, ILE515K, ILE60L, LEU183L, LEU23L, LEU259K, LEU40L, LEU456L, LEU513K, LEU524K, LEU62L, LYS117K, LYS226K, LYS242L, LYS245L, LYS277K, LYS28L, LYS327K, LYS34L, LYS42L, LYS4K, LYS51L, LYS65L, LYS7K, MET114K, MET520K, MET69K, MET73K, PHE281K, PHE8K, PRO113K, PRO33L, PRO47L, SER217L, SER228K, SER43L, THR181L, THR30L, THR385L, THR482L, THR516K, THR517K, THR522K, VAL107K, VAL22L, VAL27L, VAL29L, VAL387L, VAL38L, VAL39L, VAL455L, VAL521K, VAL56L, VAL6K
• L-M: ALA241M, ALA243M, ALA24M, ALA26M, ALA384M, ALA3L, ALA46M, ARG118L, ARG13L, ARG18M, ARG231L, ARG36M, ARG58M, ASN112L, ASN21M, ASN229L, ASN37M, ASN433L, ASN68L, ASN68M, ASP115L, ASP25M, ASP328L, ASP41M, ASP435L, ASP523L, ASP5L, ASP64M, CYS519L, GLN432L, GLN436L, GLN72L, GLU257L, GLU386M, GLU388M, GLU460M, GLU483M, GLU518L, GLU59M, GLU61L, GLU61M, GLU63M, GLU67M, GLU76L, GLY19M, GLY244M, GLY32M, GLY35M, GLY512L, ILE49M, ILE515L, ILE60M, LEU23M, LEU40M, LEU513L, LEU524L, LEU62M, LYS117L, LYS242M, LYS277L, LYS28M, LYS327L, LYS34M, LYS42M, LYS4L, LYS51M, LYS65L, LYS75L, LYS75M, LYS7L, LYS80L, MET114L, MET514L, MET520L, MET69L, MET73L, PHE8L, PRO113L, PRO33M, PRO47M, SER228L, SER43M, SER509L, THR181M, THR385M, THR516L, THR517L, THR522L, VAL107L, VAL22M, VAL27M, VAL29M, VAL387M, VAL38M, VAL39M, VAL510L, VAL521L, VAL56M, VAL6L
• M-N: ALA3M, ASN112M, ASP115M, ASP41N, ASP523M, GLN432M, GLU460N, GLU483N, GLU59N, GLU61N, GLU63N, LEU62N, LYS34N, LYS4M
• O-P: ARG37P, ARG4O, ARG9O, ASN45O, ASN51O, ASN80O, ASP58P, GLU50O, GLU50P, GLU76O, GLU88P, GLY23P, HIS7O, ILE91P, ILE94P, LEU6O, LEU92P, LYS55P
• O-U: ARG37O, ARG4U, ASN51U, ASN80U, ASP58O, GLU50O, GLU50U, GLU76U, GLU88O, GLY23O, GLY52O, HIS7U, ILE94O, LEU6U, LEU92O, LYS55O, SER21O
• P-Q: ARG37Q, ARG4P, ARG9P, ASN51P, ASN68Q, ASN80P, ASP58Q, GLU50P, GLU50Q, GLU76P, GLU88Q, GLY23Q, HIS7P, ILE91Q, ILE94Q, LEU6P, LEU92Q, LYS55Q, LYS74P
• Q-R: ARG37R, ARG4Q, ARG9Q, ASN45Q, ASN51Q, ASN68R, ASP58R, GLU50Q, GLU50R, GLU76Q, GLU88R, HIS7Q, ILE91R, ILE94R, LEU6Q, LEU92R, LYS55R, LYS74Q
• R-S: ALA22S, ARG37S, ARG4R, ASN45R, ASN51R, ASN68S, ASN80R, ASP58S, GLU50R, GLU50S, GLU76R, GLU88S, HIS7R, ILE94S, LEU6R, LEU92S, LYS55S, LYS74R
• S-T: ALA22T, ARG37T, ARG4S, ARG9S, ASN45S, ASN51S, ASN80S, ASP58T, GLU50S, GLU50T, GLU76S, GLU88T, HIS7S, ILE91T, ILE94T, LEU6S, LEU92T, LYS55T
• T-U: ARG37U, ARG4T, ARG9T, ASN45T, ASN51T, ASP58U, GLU50T, GLU50U, GLU76T, GLU88U, HIS7T, ILE91U, ILE94U, LEU6T, LEU92U, LYS55U