2BZR

crystal structure of accd5 (rv3280), an acyl-coa carboxylase beta-subunit from mycobacterium tuberculosis

• Total interactions analyzed: 15
• Total true interactions: 15
• Strongest Interaction:
  • Chains: B-E
  • Int. Res.: 413
  • Norm. En. per Res.: -4.4295
• Hub Node: A(5)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-65.0415	-20.0881	-322.76	-407.8896	143	19	8	14236	5	48	56
A-C	-54.8986	-36.8621	-326.164	-417.9247	147	9	8	14232	4	47	56
A-D	-202.9665	-238.6082	-1399.73	-1841.3047	418	49	61	55830	20	72	107
A-E	0.0	0.0	-0.0376	-0.0376	2	0	0	13	0	0	0
A-F	0.0	4.9518	-3.8042	1.1476	21	0	0	401	0	12	10
B-C	-46.4114	-5.7393	-313.861	-366.0116	140	21	8	13821	5	47	55
B-D	0.0	5.0577	-4.8264	0.2313	20	0	0	430	0	12	8
B-E	-214.5333	-212.62	-1402.25	-1829.4033	413	46	60	55584	18	72	107
B-F	0.0	0.0	-0.0106	-0.0106	2	0	0	7	0	0	0
C-D	0.0	0.0	-0.0354	-0.0354	2	0	0	12	0	0	0
C-E	0.0	4.9921	-4.6402	0.3519	20	0	0	454	0	12	10
C-F	-202.1878	-215.1245	-1394.13	-1811.4424	413	57	60	55494	21	70	106
D-E	-61.0767	-33.3465	-330.495	-424.9182	142	17	8	14144	7	47	55
D-F	-90.6826	-49.8177	-334.639	-475.1392	143	15	8	14431	6	47	57
E-F	-50.6178	-37.8376	-325.746	-414.2015	146	15	8	14489	7	49	54

Interface residues

• A-B: ALA139B, ALA26B, ALA30B, ALA451A, ALA455A, ALA505A, ALA506A, ALA513A, ALA527A, ALA77B, ALA79B, ARG108B, ARG144B, ARG347A, ARG35B, ARG36B, ARG429A, ARG508A, ARG529A, ARG533A, ARG82B, ARG92B, ASN272B, ASN292A, ASN449A, ASN501A, ASP109B, ASP21B, ASP301A, ASP306A, ASP447A, ASP497A, ASP68B, ASP70B, ASP76B, ASP96B, CYS111B, CYS446A, GLN456A, GLN493A, GLU126B, GLU130B, GLU137B, GLU290A, GLU291A, GLU31B, GLU494A, GLU496A, GLU507A, GLU532A, GLU69B, GLU74B, GLY101B, GLY103B, GLY107B, GLY143B, GLY27B, GLY287A, GLY445A, GLY509A, GLY512A, GLY522A, GLY525A, GLY95B, HIS23B, HIS33B, HIS519A, HIS81B, ILE140B, ILE22B, ILE289A, ILE304A, ILE424A, ILE515A, ILE524A, LEU138B, LEU298A, LEU29B, LEU300A, LEU303A, LEU32B, LEU450A, LEU528A, LEU530A, LEU531A, LEU75B, LEU78B, LEU94B, LYS131B, LYS134B, LYS141B, LYS28B, LYS34B, LYS423A, LYS442A, LYS534A, LYS80B, PHE72B, PRO145B, PRO271B, PRO285A, PRO288A, PRO305A, PRO308A, PRO422A, PRO453A, PRO502A, PRO516A, PRO517A, PRO93B, SER274B, SER307A, SER518A, SER71B, THR100B, THR104B, THR142B, THR24B, THR25B, THR275B, THR286A, THR302A, THR420A, THR428A, THR454A, THR498A, THR526A, TRP452A, TYR102B, TYR503A, TYR510A, TYR523A, VAL110B, VAL127B, VAL135B, VAL162B, VAL421A, VAL448A, VAL500A, VAL504A, VAL511A, VAL514A, VAL73B
• A-C: ALA139A, ALA26A, ALA30A, ALA451C, ALA455C, ALA505C, ALA506C, ALA513C, ALA527C, ALA77A, ALA79A, ARG108A, ARG144A, ARG347C, ARG35A, ARG36A, ARG429C, ARG508C, ARG529C, ARG533C, ARG82A, ARG92A, ASN272A, ASN292C, ASN449C, ASN501C, ASP106A, ASP109A, ASP21A, ASP21A5, ASP301C, ASP306C, ASP447C, ASP497C, ASP68A, ASP70A, ASP76A, ASP96A, CB8.1403727.48586, CYS111A, CYS446C, GLN456C, GLN493C, GLU126A, GLU130A, GLU137A, GLU290C, GLU291C, GLU31A, GLU494C, GLU496C, GLU507C, GLU532C, GLU69A, GLU74A, GLY101A, GLY103A, GLY107A, GLY143A, GLY27A, GLY287C, GLY445C, GLY509C, GLY512C, GLY522C, GLY525C, GLY95A, HIS23A, HIS33A, HIS519C, HIS81A, ILE105A, ILE140A, ILE22A, ILE289C, ILE304C, ILE424C, ILE515C, ILE524C, LEU138A, LEU293C, LEU298C, LEU29A, LEU300C, LEU303C, LEU32A, LEU450C, LEU528C, LEU530C, LEU531C, LEU75A, LEU78A, LEU94A, LYS131A, LYS134A, LYS141A, LYS28A, LYS34A, LYS423C, LYS442C, LYS534C, LYS80A, PHE72A, PRO145A, PRO271A, PRO285C, PRO288C, PRO305C, PRO308C, PRO422C, PRO453C, PRO502C, PRO516C, PRO517C, PRO93A, SER274A, SER307C, SER518C, SER71A, THR100A, THR104A, THR142A, THR24A, THR25A, THR275A, THR286C, THR302C, THR420C, THR454C, THR498C, THR526C, TRP452C, TYR102A, TYR503C, TYR510C, TYR523C, VAL110A, VAL127A, VAL135A, VAL162A, VAL421C, VAL448C, VAL500C, VAL504C, VAL511C, VAL514C, VAL73A
• A-D: ALA153A, ALA153D, ALA155A, ALA155D, ALA177A, ALA177D, ALA191A, ALA191D, ALA192A, ALA192D, ALA200A, ALA200D, ALA243A, ALA243D, ALA248A, ALA248D, ALA371A, ALA371D, ALA372A, ALA372D, ALA410A, ALA410D, ALA415A, ALA415D, ALA419A, ALA419D, ALA431A, ALA431D, ALA435A, ALA435D, ALA458A, ALA458D, ALA462A, ALA462D, ALA465A, ALA465D, ALA505A, ALA505D, ALA506A, ALA506D, ARG156A, ARG156D, ARG169A, ARG169D, ARG172A, ARG172D, ARG373A, ARG373D, ARG376A, ARG376D, ARG407A, ARG407D, ARG408A, ARG408D, ARG471A, ARG471D, ARG508A, ARG508D, ARG82A, ARG82D, ASN173A, ASN173D, ASN174A, ASN174D, ASN273A, ASN273D, ASN366A, ASN366D, ASN382A, ASN382D, ASN403A, ASN403D, ASN501A, ASN501D, ASN545A, ASN545D, ASN85A, ASN85D, ASN87A, ASN87D, ASP203A, ASP203D, ASP220A, ASP220D, ASP364A, ASP364D, ASP379A, ASP379D, ASP399A, ASP399D, ASP443A, ASP443D, ASP447A, ASP447D, CYS362A, CYS378A, CYS378D, CYS380A, CYS380D, CYS437A, CYS437D, CYS446A, CYS446D, GLN158A, GLN158D, GLN183A, GLN183D, GLN213A, GLN213D, GLN330A, GLN330D, GLN400A, GLN400D, GLN472A, GLN472D, GLN473A, GLU126A, GLU126D, GLU130A, GLU130D, GLU159A, GLU159D, GLU228A, GLU228D, GLU229A, GLU229D, GLU233A, GLU233D, GLU234A, GLU234D, GLU369A, GLU369D, GLU401A, GLU401D, GLU418A, GLU418D, GLU494A, GLU494D, GLU507A, GLU507D, GLU90D, GLY125A, GLY154A, GLY154D, GLY160A, GLY160D, GLY165A, GLY165D, GLY179A, GLY179D, GLY193A, GLY193D, GLY194A, GLY194D, GLY218A, GLY218D, GLY227A, GLY227D, GLY236A, GLY236D, GLY237A, GLY237D, GLY246A, GLY246D, GLY393A, GLY393D, GLY397A, GLY397D, GLY404A, GLY404D, GLY409A, GLY409D, GLY417A, GLY417D, GLY433A, GLY433D, GLY434A, GLY434D, GLY440A, GLY440D, GLY445A, GLY445D, GLY461A, GLY461D, GLY464A, GLY464D, GLY467A, GLY467D, GLY544A, GLY544D, HIS195A, HIS195D, HIS241A, HIS241D, HIS249A, HIS249D, HIS543A, HIS543D, ILE157A, ILE157D, ILE170A, ILE170D, ILE175A, ILE175D, ILE181A, ILE181D, ILE187A, ILE187D, ILE216A, ILE216D, ILE222A, ILE222D, ILE365A, ILE365D, ILE383A, ILE383D, ILE385A, ILE385D, ILE405A, ILE405D, ILE406A, ILE406D, ILE427A, ILE427D, ILE457A, ILE457D, LEU124A, LEU124D, LEU164A, LEU164D, LEU166A, LEU166D, LEU176A, LEU176D, LEU201A, LEU201D, LEU235A, LEU235D, LEU363A, LEU363D, LEU395A, LEU395D, LEU412A, LEU412D, LEU413A, LEU413D, LEU491A, LEU491D, LEU499A, LEU499D, LEU548A, LEU548D, LEU88A, LEU88D, LYS223A, LYS223D, LYS244A, LYS244D, LYS370A, LYS370D, LYS411A, LYS411D, LYS423A, LYS423D, LYS442A, LYS442D, LYS534A, LYS534D, LYS541A, LYS541D, LYS542A, LYS542D, MET207A, MET207D, MET214A, MET214D, MET232A, MET232D, MET439A, MET439D, MET444A, MET444D, MET460A, MET460D, PHE120D, PHE171A, PHE171D, PHE204A, PHE204D, PHE215A, PHE215D, PHE374A, PHE374D, PHE381A, PHE381D, PHE394A, PHE394D, PHE468A, PHE468D, PHE86A, PHE86D, PRO182A, PRO199A, PRO199D, PRO219A, PRO219D, PRO396A, PRO396D, PRO422A, PRO422D, PRO502A, PRO502D, PRO547A, PRO547D, SER123A, SER123D, SER163A, SER163D, SER168A, SER168D, SER178A, SER178D, SER198A, SER198D, SER245A, SER245D, SER274A, SER274D, SER368A, SER368D, SER441A, SER441D, SER83A, SER83D, THR202A, THR202D, THR217A, THR217D, THR224A, THR224D, THR226A, THR226D, THR231A, THR231D, THR240A, THR240D, THR247A, THR247D, THR377A, THR377D, THR398A, THR398D, THR420A, THR420D, THR498A, THR498D, TYR167A, TYR167D, TYR197A, TYR197D, TYR333A, TYR333D, TYR402A, TYR402D, TYR414A, TYR414D, TYR416A, TYR416D, TYR432A, TYR432D, TYR436A, TYR436D, TYR470A, TYR470D, TYR495A, TYR495D, TYR503A, TYR503D, TYR510A, TYR510D, VAL133A, VAL133D, VAL161A, VAL161D, VAL162A, VAL162D, VAL180A, VAL180D, VAL196A, VAL196D, VAL205A, VAL205D, VAL221A, VAL221D, VAL225A, VAL225D, VAL230A, VAL230D, VAL375A, VAL375D, VAL421A, VAL421D, VAL438A, VAL438D, VAL459A, VAL459D, VAL466A, VAL466D, VAL469A, VAL469D, VAL500A, VAL500D, VAL504A, VAL504D, VAL511A, VAL511D, VAL546A, VAL546D
• A-E: ARG508A, ARG508E
• A-F: ARG169A, ARG169F, ARG172A, ARG172F, ARG82A, ARG82F, ASN85A, ASN85F, GLU126A, GLU126F, GLU130A, GLU130F, GLU137F, LYS141A, LYS141F, SER83A, SER83F, THR84A, THR84F, VAL162A, VAL162F
• B-C: ALA139C, ALA26C, ALA30C, ALA451B, ALA455B, ALA505B, ALA506B, ALA513B, ALA527B, ALA77C, ALA79C, ARG108C, ARG144C, ARG35C, ARG36C, ARG429B, ARG508B, ARG529B, ARG533B, ARG82C, ARG92C, ASN272C, ASN292B, ASN449B, ASN501B, ASP109C, ASP21C, ASP301B, ASP306B, ASP447B, ASP497B, ASP70C, ASP76C, ASP96C, CYS111C, CYS446B, GLN456B, GLN493B, GLU126C, GLU130C, GLU137C, GLU290B, GLU291B, GLU31C, GLU494B, GLU496B, GLU507B, GLU532B, GLU69C, GLU74C, GLY101C, GLY103C, GLY107C, GLY143C, GLY27C, GLY287B, GLY445B, GLY509B, GLY512B, GLY522B, GLY525B, GLY95C, HIS23C, HIS33C, HIS519B, HIS81C, ILE140C, ILE22C, ILE289B, ILE304B, ILE424B, ILE515B, ILE524B, LEU138C, LEU298B, LEU29C, LEU300B, LEU303B, LEU32C, LEU450B, LEU499B, LEU528B, LEU530B, LEU531B, LEU75C, LEU78C, LEU94C, LYS131C, LYS134C, LYS141C, LYS28C, LYS34C, LYS423B, LYS442B, LYS534B, LYS80C, PHE72C, PRO145C, PRO271C, PRO285B, PRO288B, PRO305B, PRO308B, PRO422B, PRO453B, PRO502B, PRO516B, PRO517B, PRO93C, SER274C, SER307B, SER518B, SER71C, THR104C, THR142C, THR24C, THR25C, THR275C, THR286B, THR302B, THR420B, THR428B, THR454B, THR498B, THR526B, TRP452B, TYR102C, TYR503B, TYR510B, TYR523B, VAL110C, VAL127C, VAL135C, VAL421B, VAL448B, VAL500B, VAL504B, VAL511B, VAL514B, VAL73C
• B-D: ARG169B, ARG169D, ARG172B, ARG172D, ARG82B, ARG82D, ASN85B, ASN85D, GLU126B, GLU126D, GLU130B, GLU130D, LYS141B, LYS141D, SER83B, SER83D, THR84B, THR84D, VAL162B, VAL162D
• B-E: ALA153B, ALA153E, ALA155B, ALA155E, ALA177B, ALA177E, ALA191B, ALA191E, ALA192B, ALA192E, ALA200B, ALA200E, ALA243B, ALA243E, ALA248B, ALA248E, ALA371B, ALA371E, ALA372B, ALA372E, ALA410B, ALA410E, ALA415B, ALA415E, ALA419B, ALA419E, ALA431B, ALA431E, ALA435B, ALA435E, ALA458B, ALA458E, ALA462B, ALA462E, ALA465B, ALA465E, ALA505B, ALA505E, ALA506B, ALA506E, ARG156B, ARG156E, ARG169B, ARG169E, ARG172B, ARG172E, ARG373B, ARG373E, ARG376B, ARG376E, ARG407B, ARG407E, ARG408B, ARG408E, ARG471E, ARG508B, ARG508E, ARG82B, ARG82E, ASN173B, ASN173E, ASN174B, ASN174E, ASN273B, ASN273E, ASN366B, ASN366E, ASN382B, ASN382E, ASN403B, ASN403E, ASN501B, ASN501E, ASN545B, ASN545E, ASN85B, ASN85E, ASN87B, ASN87E, ASP203B, ASP203E, ASP220B, ASP220E, ASP364B, ASP364E, ASP379B, ASP379E, ASP399B, ASP399E, ASP443B, ASP443E, ASP447B, ASP447E, CYS362B, CYS378B, CYS378E, CYS380B, CYS380E, CYS437B, CYS437E, CYS446B, CYS446E, GLN158B, GLN158E, GLN183B, GLN183E, GLN213B, GLN213E, GLN330B, GLN330E, GLN400B, GLN400E, GLN456B, GLN456E, GLU126B, GLU126E, GLU130B, GLU130E, GLU159B, GLU159E, GLU228B, GLU228E, GLU229B, GLU229E, GLU233B, GLU233E, GLU234B, GLU234E, GLU369B, GLU369E, GLU401B, GLU401E, GLU418B, GLU418E, GLU494B, GLU494E, GLU507B, GLY125E, GLY154B, GLY154E, GLY160B, GLY160E, GLY165B, GLY165E, GLY179B, GLY179E, GLY193B, GLY193E, GLY194B, GLY194E, GLY218B, GLY218E, GLY227B, GLY227E, GLY236B, GLY236E, GLY237B, GLY237E, GLY246B, GLY246E, GLY393B, GLY393E, GLY397B, GLY397E, GLY404B, GLY404E, GLY409B, GLY409E, GLY417B, GLY417E, GLY433B, GLY433E, GLY434B, GLY434E, GLY440B, GLY440E, GLY445B, GLY445E, GLY461B, GLY461E, GLY464B, GLY464E, GLY467B, GLY467E, GLY544B, GLY544E, HIS195B, HIS195E, HIS241B, HIS241E, HIS249B, HIS249E, HIS543B, HIS543E, ILE140B, ILE140E, ILE157B, ILE157E, ILE170B, ILE170E, ILE175B, ILE175E, ILE181B, ILE181E, ILE187B, ILE187E, ILE216B, ILE216E, ILE222B, ILE222E, ILE365B, ILE365E, ILE383B, ILE383E, ILE385B, ILE385E, ILE405B, ILE405E, ILE406B, ILE406E, ILE427E, ILE457B, ILE457E, LEU124B, LEU124E, LEU164B, LEU164E, LEU166B, LEU166E, LEU176B, LEU176E, LEU201B, LEU201E, LEU235B, LEU235E, LEU363B, LEU363E, LEU395B, LEU395E, LEU412B, LEU412E, LEU413B, LEU413E, LEU491B, LEU491E, LEU499B, LEU499E, LEU548B, LEU548E, LEU88B, LEU88E, LYS223B, LYS223E, LYS244B, LYS244E, LYS370B, LYS370E, LYS411B, LYS411E, LYS423B, LYS423E, LYS442B, LYS442E, LYS534B, LYS534E, LYS541B, LYS541E, LYS542B, LYS542E, MET207B, MET207E, MET214B, MET214E, MET232B, MET232E, MET439B, MET439E, MET444B, MET444E, MET460B, MET460E, PHE171B, PHE171E, PHE204B, PHE204E, PHE215B, PHE215E, PHE374B, PHE374E, PHE381B, PHE381E, PHE394B, PHE394E, PHE468B, PHE468E, PHE86B, PHE86E, PRO182B, PRO199B, PRO199E, PRO219B, PRO219E, PRO396B, PRO396E, PRO422B, PRO422E, PRO502B, PRO502E, PRO547B, PRO547E, SER123B, SER123E, SER163B, SER163E, SER168B, SER168E, SER178B, SER178E, SER198B, SER198E, SER245B, SER245E, SER274B, SER274E, SER368B, SER368E, SER441B, SER441E, SER83B, SER83E, THR202B, THR202E, THR217B, THR217E, THR224B, THR224E, THR226B, THR226E, THR231B, THR231E, THR240B, THR240E, THR247B, THR247E, THR377B, THR377E, THR398B, THR398E, THR420B, THR420E, THR498B, THR498E, TYR167B, TYR167E, TYR197B, TYR197E, TYR333B, TYR333E, TYR402B, TYR402E, TYR414B, TYR414E, TYR416B, TYR416E, TYR432B, TYR432E, TYR436B, TYR436E, TYR470B, TYR470E, TYR495B, TYR495E, TYR503B, TYR510B, TYR510E, VAL133B, VAL133E, VAL161B, VAL161E, VAL162B, VAL162E, VAL180B, VAL180E, VAL196B, VAL196E, VAL205B, VAL205E, VAL221B, VAL221E, VAL225B, VAL225E, VAL230B, VAL230E, VAL375B, VAL375E, VAL421B, VAL421E, VAL438B, VAL438E, VAL459B, VAL459E, VAL466B, VAL466E, VAL469B, VAL469E, VAL500B, VAL500E, VAL504B, VAL504E, VAL511B, VAL511E, VAL546B, VAL546E
• B-F: ARG508B, ARG508F
• C-D: ARG508C, ARG508D
• C-E: ARG169C, ARG169E, ARG172C, ARG172E, ARG82C, ARG82E, ASN85C, ASN85E, GLU126C, GLU126E, GLU130C, GLU130E, LYS141C, LYS141E, SER83C, SER83E, THR84C, THR84E, VAL162C, VAL162E
• C-F: ALA153C, ALA153F, ALA155C, ALA155F, ALA177C, ALA177F, ALA191C, ALA191F, ALA192C, ALA192F, ALA200C, ALA200F, ALA243C, ALA243F, ALA248C, ALA248F, ALA371C, ALA371F, ALA372C, ALA372F, ALA410C, ALA410F, ALA415C, ALA415F, ALA419C, ALA419F, ALA431C, ALA431F, ALA435C, ALA435F, ALA458C, ALA458F, ALA462C, ALA462F, ALA465C, ALA465F, ALA505C, ALA505F, ALA506C, ALA506F, ARG156C, ARG156F, ARG169C, ARG169F, ARG172C, ARG172F, ARG373C, ARG373F, ARG376C, ARG376F, ARG407C, ARG407F, ARG408C, ARG408F, ARG471C, ARG508C, ARG508F, ARG82C, ARG82F, ASN173C, ASN173F, ASN174C, ASN174F, ASN273C, ASN273F, ASN366C, ASN366F, ASN382C, ASN382F, ASN403C, ASN403F, ASN501C, ASN501F, ASN545C, ASN545F, ASN85C, ASN85F, ASN87C, ASN87F, ASP203C, ASP203F, ASP220C, ASP220F, ASP364C, ASP364F, ASP379C, ASP379F, ASP399C, ASP399F, ASP443C, ASP443F, ASP447C, ASP447F, CYS362C, CYS378C, CYS378F, CYS380C, CYS380F, CYS437C, CYS437F, CYS446C, CYS446F, GLN158C, GLN158F, GLN183C, GLN183F, GLN213C, GLN213F, GLN330C, GLN330F, GLN400C, GLN400F, GLN456F, GLU126C, GLU126F, GLU130C, GLU130F, GLU159C, GLU159F, GLU228C, GLU228F, GLU229C, GLU229F, GLU233C, GLU233F, GLU234C, GLU234F, GLU369C, GLU369F, GLU401C, GLU401F, GLU418C, GLU418F, GLU494C, GLU494F, GLU507C, GLU507F, GLY125F, GLY154C, GLY154F, GLY160C, GLY160F, GLY165C, GLY165F, GLY179C, GLY179F, GLY193C, GLY193F, GLY194C, GLY194F, GLY218C, GLY218F, GLY227C, GLY227F, GLY236C, GLY236F, GLY237C, GLY237F, GLY246C, GLY246F, GLY393C, GLY393F, GLY397C, GLY397F, GLY404C, GLY404F, GLY409C, GLY409F, GLY417C, GLY417F, GLY433C, GLY433F, GLY434C, GLY434F, GLY440C, GLY440F, GLY445C, GLY445F, GLY461C, GLY461F, GLY464C, GLY464F, GLY467C, GLY467F, GLY544C, GLY544F, HIS195C, HIS195F, HIS241C, HIS241F, HIS249C, HIS249F, HIS543C, HIS543F, ILE157C, ILE157F, ILE170C, ILE170F, ILE175C, ILE175F, ILE181C, ILE181F, ILE187C, ILE187F, ILE216C, ILE216F, ILE222C, ILE222F, ILE365C, ILE365F, ILE383C, ILE383F, ILE385C, ILE385F, ILE405C, ILE405F, ILE406C, ILE406F, ILE427C, ILE457C, ILE457F, LEU124C, LEU124F, LEU164C, LEU164F, LEU166C, LEU166F, LEU176C, LEU176F, LEU201C, LEU201F, LEU235C, LEU235F, LEU363C, LEU363F, LEU395C, LEU395F, LEU412C, LEU412F, LEU413C, LEU413F, LEU491C, LEU491F, LEU499C, LEU499F, LEU548C, LEU548F, LEU88C, LEU88F, LYS223C, LYS223F, LYS244C, LYS244F, LYS370C, LYS370F, LYS411C, LYS411F, LYS423C, LYS423F, LYS442C, LYS442F, LYS534C, LYS534F, LYS541C, LYS541F, LYS542C, LYS542F, MET207C, MET207F, MET214C, MET214F, MET232C, MET232F, MET439C, MET444C, MET444F, MET460C, MET460F, PHE171C, PHE171F, PHE204C, PHE204F, PHE215C, PHE215F, PHE374C, PHE374F, PHE381C, PHE381F, PHE394C, PHE394F, PHE468C, PHE468F, PHE86C, PHE86F, PRO182C, PRO182F, PRO199C, PRO199F, PRO219C, PRO219F, PRO384F, PRO396C, PRO396F, PRO422C, PRO422F, PRO502C, PRO502F, PRO547C, PRO547F, SER123F, SER163C, SER163F, SER168C, SER168F, SER178C, SER178F, SER198C, SER198F, SER245C, SER245F, SER274C, SER274F, SER368C, SER368F, SER441C, SER441F, SER463F, SER83C, SER83F, THR202C, THR202F, THR217C, THR217F, THR224C, THR224F, THR226C, THR226F, THR231C, THR231F, THR240C, THR240F, THR247C, THR247F, THR377C, THR377F, THR398C, THR398F, THR420C, THR420F, THR498C, THR498F, TYR167C, TYR167F, TYR197C, TYR197F, TYR333C, TYR333F, TYR402C, TYR402F, TYR414C, TYR414F, TYR416C, TYR416F, TYR432C, TYR432F, TYR436C, TYR436F, TYR470C, TYR470F, TYR495C, TYR495F, TYR503C, TYR503F, TYR510C, TYR510F, VAL133C, VAL133F, VAL161C, VAL161F, VAL162C, VAL162F, VAL180C, VAL180F, VAL196C, VAL196F, VAL205C, VAL205F, VAL221C, VAL221F, VAL225C, VAL225F, VAL230C, VAL230F, VAL375C, VAL375F, VAL421C, VAL421F, VAL438C, VAL438F, VAL459C, VAL459F, VAL466C, VAL466F, VAL469C, VAL469F, VAL500C, VAL500F, VAL504C, VAL504F, VAL511C, VAL511F, VAL546C, VAL546F
• D-E: ALA139D, ALA26D, ALA30D, ALA451E, ALA455E, ALA505E, ALA506E, ALA513E, ALA527E, ALA77D, ALA79D, ARG108D, ARG144D, ARG347E, ARG35D, ARG36D, ARG429E, ARG508E, ARG529E, ARG533E, ARG82D, ARG92D, ASN272D, ASN292E, ASN449E, ASN501E, ASP106D, ASP109D, ASP21D, ASP301E, ASP306E, ASP447E, ASP497E, ASP68D, ASP70D, ASP76D, ASP96D, CYS111D, CYS446E, GLN456E, GLN493E, GLU126D, GLU130D, GLU137D, GLU290E, GLU291E, GLU31D, GLU494E, GLU496E, GLU507E, GLU532E, GLU69D, GLU74D, GLY101D, GLY103D, GLY107D, GLY143D, GLY27D, GLY287E, GLY445E, GLY509E, GLY512E, GLY522E, GLY525E, GLY95D, HIS23D, HIS33D, HIS519E, HIS81D, ILE105D, ILE140D, ILE22D, ILE289E, ILE304E, ILE424E, ILE515E, ILE524E, LEU138D, LEU293E, LEU298E, LEU29D, LEU300E, LEU303E, LEU32D, LEU450E, LEU528E, LEU530E, LEU531E, LEU75D, LEU78D, LEU94D, LYS131D, LYS134D, LYS141D, LYS28D, LYS423E, LYS442E, LYS534E, LYS80D, PHE72D, PRO145D, PRO271D, PRO285E, PRO288E, PRO305E, PRO308E, PRO422E, PRO453E, PRO502E, PRO516E, PRO517E, SER307E, SER518E, SER71D, THR104D, THR142D, THR24D, THR25D, THR275D, THR286E, THR302E, THR420E, THR428E, THR454E, THR498E, THR526E, TRP452E, TYR102D, TYR503E, TYR510E, TYR523E, VAL110D, VAL127D, VAL135D, VAL162D, VAL421E, VAL448E, VAL500E, VAL504E, VAL511E, VAL514E, VAL73D
• D-F: ALA139F, ALA26F, ALA30F, ALA451D, ALA455D, ALA505D, ALA506D, ALA513D, ALA527D, ALA77F, ALA79F, ARG108F, ARG144F, ARG347D, ARG35F, ARG36F, ARG429D, ARG508D, ARG529D, ARG533D, ARG82F, ARG92F, ASN272F, ASN292D, ASN449D, ASN501D, ASP106F, ASP109F, ASP21F, ASP301D, ASP306D, ASP447D, ASP497D, ASP68F, ASP70F, ASP76F, ASP96F, CYS111F, CYS446D, GLN456D, GLN493D, GLU126F, GLU130F, GLU137F, GLU290D, GLU291D, GLU31F, GLU494D, GLU496D, GLU507D, GLU532D, GLU69F, GLU74F, GLY101F, GLY103F, GLY107F, GLY143F, GLY27F, GLY287D, GLY445D, GLY509D, GLY512D, GLY522D, GLY525D, GLY95F, HIS23F, HIS33F, HIS519D, HIS81F, ILE105F, ILE140F, ILE22F, ILE289D, ILE304D, ILE424D, ILE515D, ILE524D, LEU138F, LEU293D, LEU298D, LEU29F, LEU300D, LEU303D, LEU32F, LEU450D, LEU528D, LEU530D, LEU531D, LEU75F, LEU78F, LEU94F, LYS131F, LYS134F, LYS141F, LYS28F, LYS34F, LYS423D, LYS442D, LYS534D, LYS80F, PHE72F, PRO145F, PRO271F, PRO285D, PRO288D, PRO305D, PRO308D, PRO422D, PRO453D, PRO502D, PRO516D, PRO517D, PRO93F, SER307D, SER518D, SER71F, THR104F, THR142F, THR24F, THR25F, THR275F, THR286D, THR302D, THR420D, THR454D, THR498D, THR526D, TRP452D, TYR102F, TYR503D, TYR510D, TYR523D, VAL110F, VAL127F, VAL135F, VAL162F, VAL421D, VAL448D, VAL500D, VAL504D, VAL511D, VAL514D, VAL73F
• E-F: ALA139E, ALA26E, ALA30E, ALA451F, ALA455F, ALA505F, ALA506F, ALA513F, ALA527F, ALA77E, ALA79E, ARG108E, ARG144E, ARG347F, ARG35E, ARG36E, ARG429F, ARG508F, ARG529F, ARG533F, ARG82E, ARG92E, ASN272E, ASN273E, ASN292F, ASN382E, ASN449F, ASN501F, ASP109E, ASP21E, ASP276E, ASP301F, ASP306F, ASP447F, ASP497F, ASP68E, ASP70E, ASP76E, ASP96E, CYS111E, CYS446F, GLN456F, GLN493F, GLU126E, GLU130E, GLU137E, GLU290F, GLU291F, GLU31E, GLU494F, GLU496F, GLU507F, GLU532F, GLU69E, GLU74E, GLY101E, GLY103E, GLY107E, GLY143E, GLY27E, GLY287F, GLY445F, GLY509F, GLY512F, GLY522F, GLY525F, GLY95E, HIS23E, HIS33E, HIS519F, HIS81E, ILE105E, ILE140E, ILE22E, ILE289F, ILE304F, ILE424F, ILE515F, ILE524F, LEU138E, LEU293F, LEU298F, LEU29E, LEU300F, LEU303F, LEU32E, LEU450F, LEU528F, LEU530F, LEU531F, LEU75E, LEU78E, LEU94E, LYS131E, LYS134E, LYS141E, LYS28E, LYS423F, LYS442F, LYS534F, LYS80E, PHE72E, PRO145E, PRO270E, PRO271E, PRO285F, PRO288F, PRO305F, PRO308F, PRO422F, PRO453F, PRO502F, PRO516F, PRO517F, PRO93E, SER274E, SER307F, SER518F, SER71E, THR104E, THR142E, THR24E, THR25E, THR275E, THR286F, THR302F, THR420F, THR428F, THR454F, THR498F, THR526F, TRP452F, TYR102E, TYR503F, TYR510F, TYR523F, VAL110E, VAL127E, VAL135E, VAL421F, VAL448F, VAL500F, VAL504F, VAL511F, VAL514F, VAL73E