2BP7

new crystal form of the pseudomonas putida branched-chain dehydrogenase (e1)

• Total interactions analyzed: 28
• Total true interactions: 14
• Strongest Interaction:
  • Chains: E-F
  • Int. Res.: 171
  • Norm. En. per Res.: -3.8904
• Hub Node: A(4)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-100.1383	27.5947	-579.228	-651.7716	170	34	8	21223	1	43	48
A-C	-46.9993	16.8226	-502.276	-532.4526	177	22	13	20023	3	28	43
A-D	-54.8361	10.8948	-408.354	-452.2953	171	14	11	16915	4	38	44
A-F	0.0	-19.0169	-45.0252	-64.0421	31	4	0	1685	1	4	5
B-C	-56.8837	12.0169	-407.11	-451.9768	172	20	10	16837	3	37	44
B-D	-47.8138	18.1298	-545.039	-574.723	182	21	4	19379	6	32	41
C-D	-80.2295	33.5382	-572.922	-619.6133	170	30	8	20968	1	43	48
C-F	-16.9107	2.0607	-29.0753	-43.9253	33	13	1	2095	0	12	14
E-F	-122.0867	32.6834	-575.849	-665.2523	171	35	7	20985	1	44	49
E-G	-47.7212	16.5045	-499.09	-530.3067	178	26	13	20113	4	28	45
E-H	-39.5498	9.8777	-392.654	-422.3261	173	17	10	16466	3	37	44
F-G	-40.7724	17.0722	-422.378	-446.0782	176	17	11	17221	4	39	46
F-H	-56.4305	17.9019	-554.491	-593.0196	183	29	4	19666	6	32	43
G-H	-55.1769	30.6108	-585.165	-609.731	172	24	6	21165	1	45	49

Interface residues

• A-B: ALA101B, ALA108B, ALA113B, ALA175A, ALA185A, ALA191A, ALA195A, ALA197A, ALA199A, ALA207A, ALA224A, ALA228A, ALA233A, ALA58B, ALA69B, ALA74B, ALA92B, ARG102B, ARG104B, ARG106B, ARG146B, ARG164A, ARG173A, ARG403A, ARG54B, ARG78B, ASN183A, ASN25B, ASP159A, ASP167B, ASP168B, ASP203A, ASP212B, ASP220A, ASP23B, ASP24B, ASP258B, ASP260B, ASP392A, ASP399A, ASP57B, ASP94B, CYS129A, CYS143B, CYS166B, GLN152A, GLN165A, GLN187A, GLN190A, GLN31B, GLN404A, GLN95B, GLU110B, GLU165B, GLU174A, GLU218A, GLU294B, GLU391A, GLU396A, GLU407A, GLU62B, GLU99B, GLY109B, GLY144B, GLY163A, GLY176A, GLY182A, GLY193A, GLY202A, GLY30B, GLY64B, GLY67B, GLY71B, GLY73B, GLY76B, HIS222A, HIS295B, HIS400A, ILE112B, ILE180A, ILE200A, ILE206A, ILE60B, ILE65B, LEU103B, LEU115B, LEU145B, LEU161A, LEU166A, LEU184A, LEU257B, LEU259B, LEU291B, LEU401A, LEU77B, LYS162A, LYS201A, LYS205A, LYS395A, LYS52B, MET100B, MET128A, MET169A, MET196A, MET389A, MET397A, MET72B, PHE111B, PHE130A, PHE139B, PHE177A, PHE178A, PHE188A, PHE221A, PHE227A, PHE390A, PHE56B, PRO114B, PRO131A, PRO160A, PRO169B, PRO256B, PRO398A, PRO59B, PRO79B, PRO91B, SER107B, SER171A, SER181A, SER198A, SER219A, SER388A, SER53B, SER61B, SER63B, SER98B, THR126A, THR140B, THR147B, THR179A, THR186A, THR204A, THR223A, THR226A, THR68B, TRP194A, TRP255B, TYR105B, TYR170A, TYR231A, TYR29B, TYR394A, TYR75B, VAL142B, VAL170B, VAL172A, VAL189A, VAL192A, VAL230A, VAL235A, VAL263B, VAL26B, VAL27B, VAL28B, VAL393A, VAL55B, VAL66B, VAL70B, VAL81B, VAL97B
• A-C: ALA195A, ALA195C, ALA197A, ALA197C, ALA199A, ALA199C, ALA207A, ALA207C, ALA215A, ALA215C, ALA217A, ALA217C, ALA228A, ALA228C, ALA233A, ALA233C, ALA251A, ALA251C, ALA253A, ALA253C, ALA261A, ALA261C, ALA290A, ALA290C, ALA293A, ALA293C, ALA44A, ALA44C, ALA45A, ALA45C, ALA48A, ALA48C, ALA5A, ALA5C, ARG232A, ARG232C, ARG263A, ARG263C, ARG287A, ARG28A, ARG28C, ARG292A, ARG292C, ARG294A, ARG294C, ARG295A, ARG295C, ARG8A, ARG8C, ASN124A, ASN124C, ASN2A, ASN2C, ASP127A, ASP203A, ASP203C, ASP220A, ASP220C, ASP43A, ASP43C, CYS267A, CYS267C, GLN250A, GLN250C, GLU218A, GLU218C, GLU256A, GLU256C, GLU291A, GLU291C, GLU3A, GLU3C, GLY193A, GLY193C, GLY202A, GLY202C, GLY214A, GLY214C, GLY254A, GLY254C, GLY255A, GLY255C, GLY262A, GLY262C, GLY264A, GLY264C, GLY266A, GLY266C, GLY268A, GLY268C, GLY296A, GLY296C, GLY298A, GLY298C, HIS10A, HIS10C, HIS222A, HIS222C, HIS229A, HIS229C, ILE200A, ILE200C, ILE206A, ILE206C, ILE211C, ILE252A, ILE252C, ILE269A, ILE269C, LEU225A, LEU225C, LEU297A, LEU297C, LEU7A, LEU7C, LEU9A, LEU9C, LYS201A, LYS201C, LYS205A, LYS205C, MET196A, MET196C, PHE221A, PHE221C, PHE227A, PHE227C, PHE260A, PHE260C, PRO12A, PRO12C, PRO234A, PRO234C, PRO299A, PRO299C, PRO6A, PRO6C, SER198A, SER198C, SER219A, SER219C, SER257A, SER257C, SER51A, SER51C, THR204A, THR204C, THR216A, THR216C, THR223A, THR223C, THR226A, THR226C, THR248A, THR248C, THR258A, THR258C, THR259A, THR259C, TRP194A, TRP194C, TYR231A, TYR231C, TYR4A, TYR4C, TYR52A, TYR52C, VAL11A, VAL11C, VAL189C, VAL192A, VAL192C, VAL230A, VAL230C, VAL265A, VAL265C, VAL40A
• A-D: ALA185A, ALA215A, ALA217A, ALA245A, ALA251A, ALA253A, ALA317D, ALA321D, ALA332D, ALA386A, ALA387A, ALA58D, ALA86D, ALA92D, ARG164A, ARG17A, ARG280D, ARG306D, ARG322A, ARG328D, ARG403A, ARG405A, ARG41D, ARG54D, ARG8A, ASN156A, ASN183A, ASP159A, ASP213A, ASP220A, ASP311D, ASP316A, ASP317A, ASP32D, ASP392A, ASP57D, ASP87D, GLN129D, GLN133D, GLN152A, GLN165A, GLN318D, GLN31D, GLN404A, GLN406A, GLN47D, GLN84D, GLU13A, GLU157A, GLU218A, GLU305D, GLU319D, GLU391A, GLU407A, GLU44D, GLU62D, GLY127D, GLY128D, GLY163A, GLY182A, GLY212A, GLY214A, GLY254A, GLY309D, GLY30D, GLY34D, GLY37D, GLY381A, GLY38D, GLY51D, GLY64D, HIS10A, HIS131D, HIS312A, HIS316D, HIS382A, HIS400A, ILE125D, ILE168A, ILE180A, ILE211A, ILE246A, ILE252A, ILE383A, ILE60D, ILE65D, LEU153A, LEU154A, LEU161A, LEU166A, LEU184A, LEU378A, LEU401A, LEU408A, LEU77D, LEU7A, LEU9A, LYS162A, LYS320A, LYS335D, LYS52D, MET103A, MET107A, MET169A, MET389A, MET72D, PHE105A, PHE249A, PHE323D, PHE36D, PHE390A, PHE40D, PHE56D, PHE85D, PHE89D, PRO12A, PRO14A, PRO167A, PRO18A, PRO313D, PRO315D, PRO318A, PRO384A, PRO398A, PRO59D, PRO91D, SER104A, SER132D, SER155A, SER181A, SER219A, SER247A, SER313A, SER315A, SER319A, SER385A, SER388A, SER53D, SER61D, SER63D, THR130D, THR179A, THR186A, THR216A, THR248A, THR279D, THR281D, THR308D, THR312D, THR377A, TRP244A, TRP310D, TRP320D, TYR126D, TYR133A, TYR29D, TYR314D, TYR321A, TYR322D, TYR35D, TYR394A, TYR75D, TYR88D, TYR90D, VAL11A, VAL27D, VAL307D, VAL33D, VAL393A, VAL39D, VAL55D
• A-F: ALA201F, ALA246F, ALA2F, ALA5A, ARG218F, ARG8A, ASN152F, ASN2A, GLN236F, GLU240F, GLU247F, GLU3A, GLY220F, HIS197F, HIS199F, ILE216F, LYS196F, PRO182F, PRO198F, PRO203F, PRO219F, PRO6A, SER200F, SER257A, THR217F, TRP194F, TYR154F, TYR233F, TYR4A, VAL232F, VAL248F
• B-C: ALA185C, ALA215C, ALA217C, ALA245C, ALA251C, ALA253C, ALA317B, ALA321B, ALA332B, ALA386C, ALA387C, ALA58B, ALA92B, ARG164C, ARG17C, ARG280B, ARG306B, ARG322C, ARG328B, ARG403C, ARG405C, ARG41B, ARG54B, ARG8C, ASN156C, ASN183C, ASP159C, ASP213C, ASP220C, ASP311B, ASP316C, ASP317C, ASP32B, ASP392C, ASP57B, ASP87B, CYS20C, GLN129B, GLN133B, GLN152C, GLN165C, GLN318B, GLN31B, GLN404C, GLN406C, GLN47B, GLN84B, GLU13C, GLU157C, GLU218C, GLU305B, GLU319B, GLU391C, GLU407C, GLU44B, GLU62B, GLY127B, GLY128B, GLY163C, GLY16C, GLY182C, GLY212C, GLY214C, GLY254C, GLY309B, GLY30B, GLY34B, GLY37B, GLY381C, GLY38B, GLY51B, GLY64B, HIS10C, HIS131B, HIS312C, HIS316B, HIS382C, HIS400C, ILE125B, ILE168C, ILE180C, ILE211C, ILE246C, ILE252C, ILE383C, ILE60B, ILE65B, LEU153C, LEU154C, LEU161C, LEU166C, LEU184C, LEU378C, LEU401C, LEU408C, LEU77B, LEU7C, LEU9C, LYS162C, LYS320C, LYS335B, LYS52B, MET103C, MET107C, MET169C, MET389C, MET397C, MET72B, PHE105C, PHE249C, PHE323B, PHE36B, PHE390C, PHE56B, PHE85B, PHE89B, PRO12C, PRO14C, PRO167C, PRO18C, PRO313B, PRO315B, PRO318C, PRO384C, PRO398C, PRO59B, PRO91B, SER104C, SER132B, SER155C, SER181C, SER219C, SER247C, SER313C, SER315C, SER319C, SER327B, SER385C, SER388C, SER53B, SER61B, SER63B, THR130B, THR186C, THR216C, THR248C, THR279B, THR281B, THR308B, THR312B, THR377C, TRP244C, TRP310B, TRP320B, TYR126B, TYR133C, TYR29B, TYR314B, TYR321C, TYR322B, TYR35B, TYR394C, TYR75B, TYR88B, TYR90B, VAL11C, VAL27B, VAL307B, VAL33B, VAL393C, VAL39B, VAL55B
• B-D: ALA101B, ALA101D, ALA108B, ALA108D, ALA137B, ALA137D, ALA278B, ALA278D, ALA286B, ALA286D, ALA302B, ALA302D, ALA92B, ALA92D, ARG102B, ARG102D, ARG104B, ARG104D, ARG106B, ARG106D, ARG271B, ARG271D, ARG280B, ARG280D, ARG306B, ARG306D, ASP311B, ASP311D, ASP87B, ASP87D, ASP94B, ASP94D, CYS143B, CYS143D, CYS272B, CYS272D, CYS282B, CYS282D, CYS296B, CYS296D, GLN129B, GLN129D, GLN133B, GLN133D, GLN141B, GLN141D, GLN293B, GLN293D, GLN318B, GLN318D, GLN95B, GLN95D, GLU136B, GLU136D, GLU287B, GLU287D, GLU294B, GLU294D, GLU301B, GLU301D, GLU305B, GLU305D, GLU338B, GLU338D, GLU62B, GLU62D, GLU99B, GLU99D, GLY128D, GLY144B, GLY144D, GLY270B, GLY270D, GLY283B, GLY283D, GLY285B, GLY285D, GLY309D, HIS131B, HIS131D, HIS276B, HIS295B, HIS295D, HIS298B, HIS298D, HIS299B, HIS299D, HIS316B, HIS316D, ILE304B, ILE304D, ILE96B, ILE96D, LEU103B, LEU103D, LEU145B, LEU145D, LEU254B, LEU254D, LEU257B, LEU257D, LEU288B, LEU288D, LEU291B, LEU291D, LEU300B, LEU300D, LYS335B, LYS335D, MET138B, MET138D, PHE139B, PHE139D, PHE284B, PHE284D, PHE297B, PHE297D, PHE89B, PHE89D, PRO135B, PRO135D, PRO256B, PRO256D, PRO303B, PRO303D, PRO313B, PRO313D, PRO315B, PRO315D, PRO91B, PRO91D, SER107B, SER107D, SER132B, SER132D, SER134B, SER134D, SER290B, SER290D, SER63B, SER63D, SER93B, SER93D, SER98B, SER98D, THR130B, THR130D, THR140B, THR140D, THR147B, THR279B, THR279D, THR281B, THR281D, THR312B, THR312D, TRP255B, TRP255D, TRP310B, TRP310D, TYR105B, TYR105D, TYR314B, TYR314D, TYR322B, TYR322D, TYR88B, TYR88D, TYR90B, TYR90D, VAL142B, VAL142D, VAL274B, VAL274D, VAL289B, VAL289D, VAL292B, VAL292D, VAL339B, VAL339D, VAL97B, VAL97D
• C-D: ALA101D, ALA108D, ALA113D, ALA175C, ALA185C, ALA191C, ALA195C, ALA197C, ALA199C, ALA207C, ALA224C, ALA228C, ALA233C, ALA58D, ALA69D, ALA74D, ALA92D, ARG102D, ARG104D, ARG106D, ARG146D, ARG164C, ARG173C, ARG403C, ARG54D, ARG78D, ASN183C, ASN25D, ASP159C, ASP167D, ASP168D, ASP203C, ASP212D, ASP220C, ASP23D, ASP24D, ASP258D, ASP260D, ASP392C, ASP399C, ASP57D, ASP94D, CYS129C, CYS143D, CYS166D, GLN152C, GLN165C, GLN187C, GLN190C, GLN31D, GLN404C, GLN95D, GLU110D, GLU165D, GLU174C, GLU218C, GLU287D, GLU294D, GLU391C, GLU396C, GLU407C, GLU62D, GLU99D, GLY109D, GLY144D, GLY163C, GLY176C, GLY182C, GLY193C, GLY202C, GLY30D, GLY64D, GLY67D, GLY71D, GLY73D, GLY76D, HIS222C, HIS295D, HIS400C, ILE112D, ILE180C, ILE200C, ILE206C, ILE60D, ILE65D, LEU103D, LEU115D, LEU145D, LEU161C, LEU166C, LEU184C, LEU257D, LEU259D, LEU291D, LEU401C, LEU77D, LYS162C, LYS201C, LYS205C, LYS395C, LYS52D, MET100D, MET128C, MET169C, MET196C, MET389C, MET397C, MET72D, PHE111D, PHE130C, PHE139D, PHE177C, PHE178C, PHE188C, PHE227C, PHE390C, PHE56D, PRO114D, PRO131C, PRO160C, PRO169D, PRO256D, PRO398C, PRO59D, PRO79D, PRO91D, SER107D, SER171C, SER181C, SER198C, SER219C, SER388C, SER53D, SER61D, SER63D, SER98D, THR126C, THR140D, THR147D, THR179C, THR186C, THR204C, THR223C, THR226C, THR68D, TRP194C, TRP255D, TYR105D, TYR170C, TYR231C, TYR29D, TYR394C, TYR75D, VAL142D, VAL170D, VAL172C, VAL189C, VAL192C, VAL230C, VAL235C, VAL263D, VAL26D, VAL27D, VAL28D, VAL393C, VAL55D, VAL66D, VAL70D, VAL81D, VAL97D
• C-F: ALA201F, ALA2F, ARG232C, ARG287C, ARG292C, ARG294C, ARG295C, ASP204F, ASP41C, ASP43C, ASP71C, GLU291C, GLU70C, GLY296C, HIS197F, HIS199F, LEU297C, LYS196F, LYS37C, MET6F, PRO182F, PRO198F, PRO203F, PRO39C, SER195F, SER200F, THR3F, THR4F, THR5F, TRP194F, VAL202F, VAL40C, VAL42C
• E-F: ALA101F, ALA108F, ALA113F, ALA175E, ALA185E, ALA191E, ALA195E, ALA197E, ALA199E, ALA207E, ALA224E, ALA228E, ALA233E, ALA58F, ALA69F, ALA74F, ALA92F, ARG102F, ARG104F, ARG106F, ARG146F, ARG164E, ARG173E, ARG403E, ARG54F, ARG78F, ASN183E, ASN25F, ASP127E, ASP159E, ASP167F, ASP168F, ASP203E, ASP212F, ASP220E, ASP23F, ASP24F, ASP258F, ASP260F, ASP392E, ASP399E, ASP57F, ASP94F, CYS129E, CYS143F, CYS166F, GLN152E, GLN165E, GLN187E, GLN190E, GLN31F, GLN404E, GLN95F, GLU110F, GLU165F, GLU174E, GLU218E, GLU294F, GLU391E, GLU396E, GLU407E, GLU62F, GLU99F, GLY109F, GLY144F, GLY163E, GLY176E, GLY182E, GLY193E, GLY202E, GLY30F, GLY64F, GLY67F, GLY71F, GLY73F, GLY76F, HIS222E, HIS295F, HIS400E, ILE112F, ILE180E, ILE200E, ILE206E, ILE60F, ILE65F, LEU103F, LEU115F, LEU145F, LEU161E, LEU166E, LEU184E, LEU257F, LEU259F, LEU291F, LEU401E, LEU77F, LYS162E, LYS201E, LYS205E, LYS395E, LYS52F, MET100F, MET128E, MET169E, MET196E, MET389E, MET397E, MET72F, PHE111F, PHE130E, PHE139F, PHE177E, PHE178E, PHE188E, PHE221E, PHE227E, PHE390E, PHE56F, PRO114F, PRO131E, PRO160E, PRO169F, PRO256F, PRO398E, PRO59F, PRO79F, PRO91F, SER107F, SER171E, SER181E, SER198E, SER219E, SER388E, SER53F, SER61F, SER63F, SER98F, THR126E, THR140F, THR147F, THR179E, THR186E, THR204E, THR223E, THR226E, THR68F, TRP194E, TRP255F, TYR105F, TYR170E, TYR231E, TYR29F, TYR394E, TYR75F, VAL142F, VAL170F, VAL172E, VAL189E, VAL192E, VAL230E, VAL235E, VAL263F, VAL26F, VAL27F, VAL28F, VAL393E, VAL55F, VAL66F, VAL70F, VAL81F, VAL97F
• E-G: ALA195E, ALA195G, ALA197E, ALA197G, ALA199E, ALA199G, ALA207E, ALA215E, ALA215G, ALA217E, ALA217G, ALA228E, ALA228G, ALA233E, ALA233G, ALA251E, ALA251G, ALA253E, ALA253G, ALA261E, ALA261G, ALA290E, ALA290G, ALA293E, ALA293G, ALA44E, ALA44G, ALA45E, ALA45G, ALA48E, ALA48G, ALA5E, ALA5G, ARG232E, ARG232G, ARG263E, ARG263G, ARG287E, ARG28E, ARG28G, ARG292E, ARG292G, ARG294E, ARG294G, ARG295E, ARG295G, ARG8E, ARG8G, ASN124E, ASN124G, ASN2E, ASN2G, ASP203E, ASP203G, ASP220E, ASP220G, ASP43E, ASP43G, CYS267E, CYS267G, GLN250E, GLN250G, GLU218E, GLU218G, GLU256E, GLU256G, GLU291E, GLU291G, GLU3E, GLU3G, GLY193E, GLY193G, GLY202E, GLY202G, GLY214E, GLY214G, GLY254E, GLY254G, GLY255E, GLY255G, GLY262E, GLY262G, GLY264E, GLY264G, GLY266E, GLY266G, GLY268E, GLY268G, GLY296E, GLY296G, GLY298E, GLY298G, HIS10E, HIS10G, HIS222E, HIS222G, HIS229E, HIS229G, ILE200E, ILE200G, ILE206E, ILE206G, ILE211E, ILE252E, ILE252G, ILE269E, ILE269G, LEU225E, LEU225G, LEU297E, LEU297G, LEU7E, LEU7G, LEU9E, LEU9G, LYS201E, LYS201G, LYS205E, LYS205G, MET196E, MET196G, PHE221E, PHE221G, PHE227E, PHE227G, PHE249G, PHE260E, PHE260G, PRO12E, PRO12G, PRO234E, PRO234G, PRO299E, PRO299G, PRO6E, PRO6G, SER198E, SER198G, SER219E, SER219G, SER257E, SER257G, SER51E, SER51G, THR204E, THR204G, THR216E, THR216G, THR223E, THR223G, THR226E, THR226G, THR248E, THR248G, THR258E, THR258G, THR259E, THR259G, TRP194E, TRP194G, TYR231E, TYR231G, TYR4E, TYR4G, TYR52E, TYR52G, VAL11E, VAL11G, VAL189E, VAL192E, VAL192G, VAL230E, VAL230G, VAL235E, VAL265E, VAL265G, VAL40E, VAL40G
• E-H: ALA185E, ALA215E, ALA217E, ALA245E, ALA251E, ALA253E, ALA317H, ALA321H, ALA332H, ALA386E, ALA387E, ALA58H, ALA86H, ALA92H, ARG164E, ARG17E, ARG280H, ARG306H, ARG322E, ARG328H, ARG403E, ARG405E, ARG41H, ARG54H, ARG8E, ASN156E, ASN183E, ASP159E, ASP213E, ASP220E, ASP311H, ASP316E, ASP317E, ASP32H, ASP392E, ASP57H, ASP87H, CYS20E, GLN129H, GLN133H, GLN152E, GLN165E, GLN318H, GLN31H, GLN404E, GLN406E, GLN47H, GLN84H, GLU13E, GLU157E, GLU218E, GLU305H, GLU319H, GLU391E, GLU407E, GLU44H, GLU62H, GLY127H, GLY128H, GLY163E, GLY16E, GLY182E, GLY212E, GLY214E, GLY254E, GLY255E, GLY309H, GLY30H, GLY34H, GLY37H, GLY381E, GLY38H, GLY51H, GLY64H, HIS10E, HIS131H, HIS312E, HIS316H, HIS382E, HIS400E, ILE125H, ILE180E, ILE211E, ILE246E, ILE252E, ILE383E, ILE60H, ILE65H, LEU153E, LEU154E, LEU161E, LEU166E, LEU184E, LEU378E, LEU401E, LEU408E, LEU77H, LEU7E, LEU9E, LYS102E, LYS162E, LYS320E, LYS335H, LYS52H, MET103E, MET107E, MET169E, MET389E, MET72H, PHE105E, PHE249E, PHE323H, PHE36H, PHE390E, PHE56H, PHE85H, PHE89H, PRO12E, PRO14E, PRO167E, PRO18E, PRO313H, PRO315H, PRO318E, PRO384E, PRO398E, PRO59H, PRO91H, SER104E, SER132H, SER155E, SER181E, SER219E, SER247E, SER313E, SER315E, SER319E, SER385E, SER388E, SER53H, SER61H, SER63H, THR130H, THR179E, THR186E, THR216E, THR248E, THR279H, THR281H, THR308H, THR312H, THR377E, TRP244E, TRP310H, TRP320H, TYR126H, TYR133E, TYR29H, TYR314H, TYR321E, TYR322H, TYR35H, TYR394E, TYR75H, TYR88H, TYR90H, VAL11E, VAL27H, VAL307H, VAL33H, VAL393E, VAL39H, VAL55H
• F-G: ALA185G, ALA215G, ALA217G, ALA245G, ALA251G, ALA253G, ALA317F, ALA321F, ALA331F, ALA332F, ALA379G, ALA386G, ALA387G, ALA58F, ALA86F, ALA92F, ARG164G, ARG17G, ARG280F, ARG306F, ARG322G, ARG328F, ARG403G, ARG405G, ARG41F, ARG54F, ARG8G, ASN156G, ASN183G, ASP159G, ASP213G, ASP220G, ASP311F, ASP316G, ASP317G, ASP32F, ASP392G, ASP57F, ASP87F, CYS20G, GLN129F, GLN133F, GLN152G, GLN165G, GLN318F, GLN31F, GLN404G, GLN406G, GLN47F, GLN84F, GLU13G, GLU157G, GLU218G, GLU305F, GLU319F, GLU391G, GLU407G, GLU44F, GLU62F, GLY127F, GLY128F, GLY163G, GLY16G, GLY182G, GLY212G, GLY214G, GLY254G, GLY255G, GLY309F, GLY30F, GLY34F, GLY37F, GLY381G, GLY38F, GLY51F, GLY64F, HIS10G, HIS131F, HIS312G, HIS316F, HIS382G, HIS400G, ILE125F, ILE180G, ILE246G, ILE252G, ILE383G, ILE60F, ILE65F, LEU153G, LEU154G, LEU161G, LEU166G, LEU184G, LEU378G, LEU401G, LEU408G, LEU77F, LEU7G, LEU9G, LYS102G, LYS162G, LYS320G, LYS335F, LYS52F, MET103G, MET107G, MET169G, MET389G, MET72F, PHE105G, PHE249G, PHE323F, PHE36F, PHE390G, PHE40F, PHE56F, PHE85F, PHE89F, PRO12G, PRO14G, PRO167G, PRO18G, PRO313F, PRO315F, PRO318G, PRO323G, PRO384G, PRO398G, PRO59F, PRO91F, SER104G, SER132F, SER155G, SER181G, SER219G, SER247G, SER313G, SER315G, SER319G, SER327F, SER385G, SER388G, SER53F, SER61F, SER63F, THR130F, THR186G, THR216G, THR248G, THR279F, THR281F, THR308F, THR312F, THR377G, TRP244G, TRP310F, TRP320F, TYR126F, TYR133G, TYR29F, TYR314F, TYR321G, TYR322F, TYR35F, TYR394G, TYR75F, TYR88F, TYR90F, VAL11G, VAL27F, VAL307F, VAL33F, VAL393G, VAL39F, VAL55F
• F-H: ALA101F, ALA101H, ALA108F, ALA108H, ALA137F, ALA137H, ALA278F, ALA278H, ALA286F, ALA286H, ALA302F, ALA302H, ALA317F, ALA92F, ALA92H, ARG102F, ARG102H, ARG104F, ARG104H, ARG106F, ARG106H, ARG271F, ARG271H, ARG280F, ARG280H, ARG306F, ARG306H, ASP311F, ASP311H, ASP87F, ASP87H, ASP94F, ASP94H, CYS143F, CYS143H, CYS272F, CYS272H, CYS282F, CYS282H, CYS296F, CYS296H, GLN129F, GLN129H, GLN133F, GLN133H, GLN141F, GLN141H, GLN293F, GLN293H, GLN318F, GLN318H, GLN95F, GLN95H, GLU136F, GLU136H, GLU287F, GLU287H, GLU294F, GLU294H, GLU301F, GLU301H, GLU305F, GLU305H, GLU338F, GLU338H, GLU62F, GLU62H, GLU99F, GLU99H, GLY128F, GLY144F, GLY144H, GLY270F, GLY270H, GLY283F, GLY283H, GLY285F, GLY285H, GLY309F, HIS131F, HIS131H, HIS276F, HIS295F, HIS295H, HIS298F, HIS298H, HIS299F, HIS299H, HIS316F, HIS316H, ILE304F, ILE304H, ILE96F, ILE96H, LEU103F, LEU103H, LEU145F, LEU145H, LEU254F, LEU254H, LEU257F, LEU257H, LEU288F, LEU288H, LEU291F, LEU291H, LEU300F, LEU300H, LYS335F, LYS335H, MET138F, MET138H, PHE139F, PHE139H, PHE284F, PHE284H, PHE297F, PHE297H, PHE89F, PHE89H, PRO135F, PRO135H, PRO256F, PRO256H, PRO303F, PRO303H, PRO313F, PRO313H, PRO315F, PRO315H, PRO91F, PRO91H, SER107F, SER107H, SER132F, SER132H, SER134F, SER134H, SER290F, SER290H, SER63F, SER63H, SER93F, SER93H, SER98F, SER98H, THR130F, THR130H, THR140F, THR140H, THR147F, THR279F, THR279H, THR281F, THR281H, THR312F, THR312H, TRP255F, TRP255H, TRP310F, TRP310H, TYR105F, TYR105H, TYR314F, TYR314H, TYR322F, TYR322H, TYR88F, TYR88H, TYR90F, TYR90H, VAL142F, VAL142H, VAL274F, VAL274H, VAL289F, VAL289H, VAL292F, VAL292H, VAL339F, VAL339H, VAL97F, VAL97H
• G-H: ALA101H, ALA108H, ALA113H, ALA175G, ALA185G, ALA191G, ALA195G, ALA197G, ALA199G, ALA207G, ALA224G, ALA228G, ALA233G, ALA387G, ALA58H, ALA69H, ALA74H, ALA92H, ARG102H, ARG104H, ARG106H, ARG146H, ARG164G, ARG173G, ARG403G, ARG54H, ARG78H, ASN183G, ASN25H, ASP159G, ASP167H, ASP168H, ASP203G, ASP212H, ASP220G, ASP23H, ASP24H, ASP258H, ASP260H, ASP392G, ASP399G, ASP57H, ASP94H, CYS129G, CYS143H, CYS166H, GLN152G, GLN165G, GLN187G, GLN190G, GLN31H, GLN404G, GLN95H, GLU110H, GLU165H, GLU174G, GLU218G, GLU294H, GLU391G, GLU396G, GLU407G, GLU62H, GLU99H, GLY109H, GLY144H, GLY163G, GLY176G, GLY182G, GLY193G, GLY202G, GLY30H, GLY64H, GLY67H, GLY71H, GLY73H, GLY76H, HIS222G, HIS295H, HIS400G, ILE112H, ILE180G, ILE200G, ILE206G, ILE60H, ILE65H, ILE96H, LEU103H, LEU115H, LEU145H, LEU161G, LEU166G, LEU184G, LEU257H, LEU259H, LEU291H, LEU401G, LEU77H, LYS162G, LYS201G, LYS205G, LYS395G, LYS52H, MET100H, MET128G, MET169G, MET196G, MET389G, MET397G, MET72H, PHE111H, PHE130G, PHE139H, PHE177G, PHE178G, PHE188G, PHE227G, PHE390G, PHE56H, PRO114H, PRO131G, PRO160G, PRO169H, PRO256H, PRO398G, PRO59H, PRO79H, PRO91H, SER107H, SER171G, SER181G, SER198G, SER219G, SER388G, SER53H, SER61H, SER63H, SER93H, SER98H, THR126G, THR140H, THR147H, THR179G, THR186G, THR204G, THR223G, THR226G, THR68H, TRP194G, TRP255H, TYR105H, TYR170G, TYR231G, TYR29H, TYR394G, TYR75H, VAL142H, VAL170H, VAL172G, VAL189G, VAL192G, VAL230G, VAL235G, VAL263H, VAL26H, VAL27H, VAL28H, VAL393G, VAL55H, VAL66H, VAL70H, VAL81H, VAL97H