2BJ0

crystal structure of achbp from bulinus truncatus revals the conserved structural scaffold and sites of variation in nicotinic acetylcholine receptors

• Total interactions analyzed: 10
• Total true interactions: 5
• Strongest Interaction:
  • Chains: A-E
  • Int. Res.: 135
  • Norm. En. per Res.: -3.019
• Hub Node: A(2)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-42.8423	-16.5077	-300.561	-359.911	131	10	7	12880	2	39	39
A-E	-63.0543	-10.1301	-334.383	-407.5674	135	12	7	13982	1	41	40
B-C	-34.6075	-5.5951	-293.873	-334.0756	134	11	7	12976	2	40	36
C-D	-29.7456	-15.2683	-294.969	-339.9829	132	11	8	12671	4	39	39
D-E	-30.0742	-1.5314	-283.061	-314.6666	131	14	7	12732	2	38	35

Interface residues

• A-B: ALA39B, ALA54B, ALA90A, ALA92A, ALA93A, ALA99B, ARG101B, ARG117B, ARG119A, ASN146A, ASN189A, ASN21A, ASN22A, ASN30B, ASN35B, ASN89A, ASP100B, ASP123A, ASP145A, ASP15A, ASP166B, ASP40A, ASP40B, ASP44A, ASP71B, ASP84A, CYS122A, CYS186A, CYS187A, GLN116B, GLN148A, GLN1B, GLN45A, GLN53B, GLN72B, GLN9A, GLU13A, GLU163B, GLU188A, GLU38B, GLU42A, GLU47B, GLU95A, GLU95B, GLY12A, GLY140A, HIS144A, ILE10A, ILE111B, ILE125A, ILE17A, ILE2B, ILE36B, ILE91A, LEU124A, LEU19A, LEU50B, LEU64B, LEU65B, LEU70B, LEU75B, LEU7B, LEU85A, LEU96B, LEU97B, LYS138A, LYS147A, LYS169B, LYS183A, LYS202B, LYS203B, LYS32B, LYS43A, LYS79B, MET190A, MET34B, MET80A, PHE120A, PHE149A, PHE170B, PHE87A, PRO114B, PRO168B, PRO18A, PRO76B, PRO83A, PRO94A, SER105B, SER115B, SER141A, SER14A, SER167B, SER185A, SER20A, SER55B, SER68B, SER69B, SER74B, SER78B, SER86A, SER98B, THR11A, THR11B, THR121A, THR143A, THR23A, THR41A, THR52B, THR82A, TRP142A, TRP4B, TRP51B, TRP81A, TYR112B, TYR164B, TYR184A, TYR191A, TYR60A, TYR88A, VAL102B, VAL103B, VAL104B, VAL113B, VAL158B, VAL16A, VAL37B, VAL48B, VAL49B, VAL58A, VAL73B, VAL77B
• A-E: ALA39A, ALA54A, ALA90E, ALA92E, ALA93E, ALA99A, ARG101A, ARG117A, ARG119A, ARG119E, ARG136E, ARG3A, ASN146E, ASN160A, ASN189E, ASN21E, ASN22E, ASN30A, ASN35A, ASN89E, ASP100A, ASP123E, ASP145E, ASP15E, ASP166A, ASP40A, ASP40E, ASP44E, ASP71A, ASP84E, CYS122E, CYS186E, CYS187E, GLN116A, GLN148E, GLN1A, GLN45E, GLN53A, GLN72A, GLN9E, GLU13E, GLU155A, GLU156A, GLU163A, GLU188E, GLU38A, GLU42E, GLU47A, GLU95A, GLY12E, GLY140E, HIS144E, ILE111A, ILE125E, ILE17E, ILE2A, ILE36A, ILE91E, LEU124E, LEU19E, LEU25E, LEU50A, LEU64A, LEU65A, LEU70A, LEU75A, LEU7A, LEU85E, LEU96A, LEU97A, LYS138E, LYS147E, LYS169A, LYS182E, LYS183E, LYS203A, LYS32A, LYS43E, LYS79A, MET34A, MET80E, PHE120E, PHE170A, PHE87E, PRO114A, PRO168A, PRO18E, PRO24E, PRO76A, PRO83E, PRO94E, SER105A, SER115A, SER141E, SER14E, SER167A, SER185E, SER20E, SER55A, SER68A, SER69A, SER74A, SER78A, SER86E, SER98A, THR11A, THR11E, THR121E, THR143E, THR23E, THR41E, THR52A, THR82E, TRP142E, TRP4A, TRP51A, TRP81E, TYR112A, TYR164A, TYR184E, TYR191E, TYR60E, TYR88E, VAL102A, VAL103A, VAL104A, VAL113A, VAL118E, VAL16E, VAL37A, VAL48A, VAL49A, VAL58E, VAL73A, VAL77A
• B-C: ALA39C, ALA90B, ALA92B, ALA93B, ALA99C, ARG101C, ARG117C, ARG119B, ARG136B, ARG3C, ASN146B, ASN160C, ASN189B, ASN21B, ASN22B, ASN30C, ASN35C, ASN89B, ASP100C, ASP123B, ASP145B, ASP15B, ASP166C, ASP40B, ASP40C, ASP44B, ASP71C, ASP84B, CYS122B, CYS186B, CYS187B, GLN116C, GLN148B, GLN1C, GLN45B, GLN53C, GLN72C, GLN9B, GLU13B, GLU155C, GLU156C, GLU163C, GLU188B, GLU38C, GLU42B, GLU47C, GLU95C, GLY12B, GLY140B, HIS144B, ILE111C, ILE125B, ILE17B, ILE2C, ILE36C, ILE91B, LEU124B, LEU19B, LEU50C, LEU64C, LEU65C, LEU70C, LEU75C, LEU7C, LEU85B, LEU96C, LEU97C, LYS106C, LYS138B, LYS147B, LYS169C, LYS182B, LYS183B, LYS203C, LYS32C, LYS43B, LYS79C, MET34C, MET80B, PHE120B, PHE170C, PHE87B, PRO114C, PRO168C, PRO18B, PRO76C, PRO83B, PRO94B, SER105C, SER115C, SER141B, SER14B, SER167C, SER185B, SER20B, SER55C, SER68C, SER69C, SER74C, SER78C, SER86B, SER98C, THR11B, THR11C, THR121B, THR143B, THR23B, THR41B, THR52C, THR82B, TRP142B, TRP4C, TRP51C, TRP81B, TYR112C, TYR164C, TYR184B, TYR191B, TYR60B, TYR61B, TYR88B, VAL102C, VAL103C, VAL104C, VAL113C, VAL118B, VAL118C, VAL16B, VAL37C, VAL48C, VAL49C, VAL58B, VAL73C, VAL77C
• C-D: ALA39D, ALA90C, ALA92C, ALA93C, ALA99D, ARG101D, ARG117D, ARG119C, ARG119D, ARG3D, ASN189C, ASN21C, ASN22C, ASN30D, ASN35D, ASN89C, ASP100D, ASP123C, ASP145C, ASP15C, ASP166D, ASP40C, ASP40D, ASP44C, ASP71D, ASP84C, CYS122C, CYS186C, CYS187C, GLN116D, GLN148C, GLN1D, GLN45C, GLN53D, GLN72D, GLN9C, GLU13C, GLU163D, GLU188C, GLU38D, GLU42C, GLU47D, GLU95D, GLY12C, GLY140C, HIS144C, ILE10C, ILE111D, ILE125C, ILE17C, ILE2D, ILE36D, ILE91C, LEU124C, LEU19C, LEU50D, LEU64D, LEU65D, LEU70D, LEU75D, LEU7D, LEU85C, LEU96D, LEU97D, LYS106D, LYS138C, LYS147C, LYS169D, LYS182C, LYS183C, LYS202D, LYS203D, LYS32D, LYS43C, LYS79D, MET34D, MET80C, PHE120C, PHE149C, PHE170D, PHE87C, PRO114D, PRO168D, PRO18C, PRO76D, PRO83C, PRO94C, SER105D, SER115D, SER141C, SER14C, SER167D, SER185C, SER20C, SER55D, SER68D, SER69D, SER74D, SER78D, SER86C, SER98D, THR11C, THR11D, THR121C, THR143C, THR23C, THR41C, THR52D, THR82C, TRP142C, TRP4D, TRP51D, TRP81C, TYR112D, TYR164D, TYR184C, TYR191C, TYR60C, TYR88C, VAL102D, VAL103D, VAL104D, VAL113D, VAL118C, VAL158D, VAL16C, VAL37D, VAL48D, VAL49D, VAL58C, VAL73D, VAL77D
• D-E: ALA39E, ALA54E, ALA90D, ALA92D, ALA93D, ALA99E, ARG101E, ARG117E, ARG119D, ARG119E, ARG3E, ASN146D, ASN189D, ASN21D, ASN22D, ASN35E, ASN89D, ASP100E, ASP123D, ASP145D, ASP15D, ASP166E, ASP40D, ASP40E, ASP44D, ASP71E, ASP84D, CYS122D, CYS186D, CYS187D, GLN116E, GLN148D, GLN1E, GLN45D, GLN53E, GLN72E, GLN9D, GLU13D, GLU163E, GLU188D, GLU38E, GLU42D, GLU47E, GLU95D, GLU95E, GLY12D, GLY140D, HIS144D, ILE111E, ILE125D, ILE17D, ILE2E, ILE36E, ILE91D, LEU124D, LEU19D, LEU50E, LEU64E, LEU65E, LEU70E, LEU75E, LEU7E, LEU85D, LEU96E, LEU97E, LYS138D, LYS147D, LYS169E, LYS183D, LYS202E, LYS203E, LYS32E, LYS43D, LYS79E, MET190D, MET34E, MET80D, PHE120D, PHE170E, PHE87D, PRO114E, PRO168E, PRO18D, PRO24D, PRO76E, PRO83D, PRO94D, SER105E, SER115E, SER141D, SER14D, SER167E, SER185D, SER20D, SER55E, SER68E, SER69E, SER74E, SER78E, SER86D, SER98E, THR11D, THR11E, THR121D, THR143D, THR23D, THR41D, THR52E, THR82D, TRP142D, TRP4E, TRP51E, TRP81D, TYR112E, TYR164E, TYR184D, TYR191D, TYR60D, TYR88D, VAL102E, VAL103E, VAL104E, VAL113E, VAL118D, VAL158E, VAL16D, VAL37E, VAL48E, VAL49E, VAL73E, VAL77E