2BFG

crystal structure of beta-xylosidase (fam gh39) in complex with dinitrophenyl-beta-xyloside and covalently bound xyloside

• Total interactions analyzed: 28
• Total true interactions: 15
• Strongest Interaction:
  • Chains: E-G
  • Int. Res.: 247
  • Norm. En. per Res.: -5.1895
• Hub Node: A(3)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	0.0	-27.2641	-19.8941	-47.1582	40	2	2	1171	0	12	18
A-C	-207.1612	-92.9265	-934.837	-1234.9246	243	79	9	32786	8	89	65
A-D	-87.5176	-73.423	-451.548	-612.4886	157	26	8	17433	4	77	89
B-C	-95.2225	-78.4681	-441.393	-615.0836	154	30	8	17118	4	73	87
B-D	-226.3303	-97.3984	-911.895	-1235.6237	246	88	8	32670	8	90	64
C-D	0.0	-17.5236	-21.6481	-39.1717	40	3	2	1312	0	14	19
C-E	-5.8822	2.3457	-118.419	-121.9555	59	3	0	4501	1	20	30
D-E	-4.387	-24.0712	-24.5129	-52.971	38	0	0	1277	2	23	23
D-F	0.0	-1.0613	-22.0673	-23.1286	19	5	0	1100	0	9	11
E-F	0.0	-29.0744	-23.6724	-52.7468	41	1	2	1273	0	14	18
E-G	-250.7621	-102.148	-928.908	-1281.8181	247	74	10	32729	8	89	64
E-H	-80.9189	-77.0209	-451.527	-609.4668	162	29	8	17376	4	74	88
F-G	-86.424	-77.6627	-449.226	-613.3127	159	23	8	17447	4	76	89
F-H	-191.6933	-93.3935	-917.835	-1202.9217	250	69	10	32906	9	89	65
G-H	0.0	-16.6375	-19.0421	-35.6796	38	1	2	1223	0	14	19

Interface residues

• A-B: ARG144A, ARG144B, ARG484A, ARG484B, ASP70A, ASP70B, GLU143A, GLU143B, GLU486A, GLU486B, GLU68A, GLU68B, GLY492A, GLY492B, HIS140A, HIS140B, ILE142A, ILE142B, ILE69A, ILE69B, LYS74A, LYS74B, PHE76A, PHE76B, PHE79A, PHE79B, SER139A, SER139B, SER488A, SER488B, THR489A, THR489B, TYR490A, TYR490B, TYR77A, TYR77B, VAL491A, VAL491B, VAL67A, VAL67B
• A-C: ALA293A, ALA293C, ALA296A, ALA296C, ALA297A, ALA297C, ALA330A, ALA330C, ALA408A, ALA408C, ALA423A, ALA423C, ALA440A, ALA440C, ALA448A, ALA448C, ARG374A, ARG374C, ARG413A, ARG413C, ARG425A, ARG425C, ARG432A, ARG432C, ARG434A, ARG434C, ARG445A, ARG445C, ARG457A, ARG457C, ARG484A, ARG484C, ASN287A, ASN287C, ASN295A, ASN295C, ASN417A, ASN417C, ASN422A, ASN422C, ASN473A, ASN473C, ASP291A, ASP291C, ASP376A, ASP485A, ASP485C, ASP494A, ASP494C, ASP495A, ASP495C, GLN245A, GLN245C, GLN414A, GLN414C, GLN419A, GLN419C, GLN429A, GLN429C, GLN439A, GLN439C, GLN446A, GLN446C, GLN449A, GLN449C, GLN456A, GLN456C, GLN482A, GLN482C, GLU241A, GLU241C, GLU246A, GLU246C, GLU248A, GLU248C, GLU389A, GLU389C, GLU392A, GLU392C, GLU418A, GLU418C, GLU442A, GLU442C, GLU455A, GLU455C, GLU479A, GLU479C, GLU481A, GLU481C, GLU486A, GLU486C, GLU497A, GLU497C, GLY334A, GLY334C, GLY391A, GLY391C, GLY431A, GLY431C, GLY492A, GLY492C, GLY496A, GLY496C, HIS236A, HIS236C, HIS290A, HIS290C, HIS333A, HIS333C, HIS350C, HIS451A, HIS451C, ILE411A, ILE411C, ILE415C, ILE498A, ILE498C, LEU247A, LEU247C, LEU294A, LEU294C, LEU331A, LEU331C, LEU386A, LEU386C, LEU394A, LEU394C, LEU444A, LEU444C, LEU477A, LEU477C, LEU493A, LEU493C, LYS237A, LYS237C, LYS238A, LYS238C, LYS329A, LYS329C, LYS390A, LYS390C, LYS412A, LYS412C, LYS428A, LYS428C, LYS45A, LYS45C, LYS472A, LYS472C, MET388A, MET388C, MET430A, MET430C, MET453A, MET453C, PHE240A, PHE240C, PHE332A, PHE332C, PHE354A, PHE354C, PHE410A, PHE410C, PHE435A, PHE435C, PRO249A, PRO249C, PRO250A, PRO250C, PRO288A, PRO288C, PRO347A, PRO347C, PRO433A, PRO433C, PRO436A, PRO436C, PRO450A, PRO450C, SER232A, SER232C, SER282A, SER282C, SER437A, SER437C, SER488A, SER488C, SER500A, SER500C, SER502A, SER502C, THR239A, THR239C, THR281A, THR281C, THR292A, THR292C, THR353C, THR443A, THR443C, THR454A, THR454C, THR487A, THR487C, THR489A, THR489C, THR499A, THR499C, TRP424A, TRP424C, TRP427A, TRP427C, TYR242A, TYR242C, TYR243A, TYR243C, TYR244A, TYR244C, TYR298A, TYR298C, TYR420A, TYR420C, TYR490A, TYR490C, TYR501A, TYR501C, VAL289A, VAL289C, VAL387A, VAL387C, VAL409A, VAL409C, VAL426A, VAL426C, VAL441C, VAL447A, VAL447C, VAL452A, VAL452C, VAL483A, VAL483C, VAL491A, VAL491C
• A-D: ALA30A, ALA30D, ALA330A, ALA330D, ALA340A, ALA340D, ALA440A, ALA440D, ALA91A, ALA91D, ARG144A, ARG144D, ARG26A, ARG26D, ARG434A, ARG434D, ARG438A, ARG438D, ARG65A, ARG65D, ARG84A, ARG84D, ASN78A, ASN78D, ASP320A, ASP320D, ASP326A, ASP326D, ASP37A, ASP37D, ASP59A, ASP59D, ASP60A, ASP60D, ASP70A, ASP70D, ASP83A, ASP83D, ASP87A, ASP87D, GLN32A, GLN32D, GLN439A, GLN439D, GLU143A, GLU143D, GLU241A, GLU241D, GLU323A, GLU323D, GLU34A, GLU34D, GLU66A, GLU66D, GLU68A, GLU68D, GLU72D, GLY28A, GLY28D, GLY62A, GLY62D, HIS140A, HIS140D, HIS333A, HIS333D, HIS342A, HIS342D, HIS38A, HIS38D, ILE63A, ILE63D, ILE69A, ILE69D, ILE82A, ILE82D, ILE85A, ILE85D, LEU29A, LEU29D, LEU31A, LEU31D, LEU331A, LEU331D, LEU341A, LEU341D, LEU36A, LEU36D, LEU90A, LEU90D, LEU92A, LEU92D, LYS105A, LYS105D, LYS118A, LYS118D, LYS238D, LYS329A, LYS329D, LYS33A, LYS33D, LYS74A, LYS74D, MET325A, MET325D, MET73A, MET73D, PHE240A, PHE240D, PHE322A, PHE322D, PHE435A, PHE435D, PHE76A, PHE76D, PHE79A, PHE79D, PRO328A, PRO328D, PRO433A, PRO433D, PRO436A, PRO436D, SER319A, SER319D, SER343A, SER343D, SER437A, SER437D, SER58A, SER88A, SER88D, THR239A, THR239D, THR80A, THR80D, TYR116A, TYR116D, TYR145A, TYR145D, TYR35A, TYR35D, TYR64A, TYR64D, TYR77A, TYR77D, TYR81A, TYR81D, VAL321A, VAL321D, VAL327A, VAL327D, VAL441A, VAL441D, VAL61A, VAL61D, VAL67A, VAL67D
• B-C: ALA30B, ALA30C, ALA330B, ALA330C, ALA340B, ALA440B, ALA440C, ALA91B, ALA91C, ARG144B, ARG144C, ARG26B, ARG26C, ARG434B, ARG434C, ARG438B, ARG438C, ARG65B, ARG65C, ARG84B, ARG84C, ASN78B, ASN78C, ASP320B, ASP320C, ASP326B, ASP326C, ASP37B, ASP37C, ASP59B, ASP59C, ASP60B, ASP60C, ASP70B, ASP70C, ASP83B, ASP83C, ASP87B, ASP87C, GLN32B, GLN32C, GLN439B, GLN439C, GLU143B, GLU143C, GLU241B, GLU241C, GLU323B, GLU323C, GLU34B, GLU34C, GLU66B, GLU66C, GLU68B, GLU68C, GLY28B, GLY28C, GLY62B, GLY62C, HIS140B, HIS140C, HIS333B, HIS333C, HIS342B, HIS342C, HIS38B, HIS38C, ILE63B, ILE63C, ILE69B, ILE69C, ILE82B, ILE82C, ILE85B, ILE85C, LEU29B, LEU29C, LEU31B, LEU31C, LEU331B, LEU331C, LEU341B, LEU341C, LEU36B, LEU36C, LEU90B, LEU90C, LEU92B, LEU92C, LYS105B, LYS105C, LYS118B, LYS118C, LYS238C, LYS329B, LYS329C, LYS33B, LYS33C, LYS40B, LYS74B, MET325B, MET325C, MET73B, MET73C, PHE240B, PHE240C, PHE322B, PHE322C, PHE435B, PHE435C, PHE76B, PHE76C, PHE79B, PHE79C, PRO328B, PRO328C, PRO433B, PRO433C, PRO436B, PRO436C, SER319B, SER319C, SER343B, SER437B, SER437C, SER58B, SER88B, SER88C, THR239B, THR239C, THR80B, THR80C, TYR116B, TYR116C, TYR145B, TYR145C, TYR35B, TYR35C, TYR64B, TYR64C, TYR77B, TYR77C, TYR81B, TYR81C, VAL321B, VAL321C, VAL327B, VAL327C, VAL441B, VAL441C, VAL61B, VAL61C, VAL67B, VAL67C
• B-D: ALA293B, ALA293D, ALA296B, ALA296D, ALA297B, ALA297D, ALA330B, ALA330D, ALA408B, ALA408D, ALA423B, ALA423D, ALA440B, ALA440D, ALA448B, ALA448D, ARG374B, ARG374D, ARG413B, ARG413D, ARG425B, ARG425D, ARG432B, ARG432D, ARG434B, ARG434D, ARG445B, ARG445D, ARG457B, ARG457D, ARG484B, ARG484D, ASN287B, ASN287D, ASN295B, ASN295D, ASN417B, ASN417D, ASN422B, ASN422D, ASN473B, ASN473D, ASP291B, ASP291D, ASP376B, ASP376D, ASP485B, ASP485D, ASP494B, ASP494D, ASP495B, ASP495D, GLN245B, GLN245D, GLN414B, GLN414D, GLN419B, GLN419D, GLN429B, GLN429D, GLN439B, GLN439D, GLN446B, GLN446D, GLN449B, GLN449D, GLN456B, GLN456D, GLN482B, GLN482D, GLU241B, GLU241D, GLU246B, GLU246D, GLU248B, GLU248D, GLU389B, GLU389D, GLU392B, GLU392D, GLU418B, GLU418D, GLU442B, GLU442D, GLU455B, GLU455D, GLU479B, GLU479D, GLU481B, GLU481D, GLU486B, GLU486D, GLU497B, GLU497D, GLY334B, GLY334D, GLY391B, GLY391D, GLY431B, GLY431D, GLY492B, GLY492D, GLY496B, GLY496D, HIS236B, HIS236D, HIS290B, HIS290D, HIS333B, HIS333D, HIS350B, HIS451B, HIS451D, ILE411B, ILE411D, ILE415B, ILE498B, ILE498D, LEU247B, LEU247D, LEU294B, LEU294D, LEU331B, LEU331D, LEU386B, LEU386D, LEU394B, LEU394D, LEU444B, LEU444D, LEU477B, LEU477D, LEU493B, LEU493D, LYS237B, LYS237D, LYS238B, LYS238D, LYS329B, LYS329D, LYS390B, LYS390D, LYS412B, LYS412D, LYS428B, LYS428D, LYS45B, LYS45D, LYS472B, LYS472D, MET388B, MET388D, MET430B, MET430D, MET453B, MET453D, PHE240B, PHE240D, PHE332B, PHE332D, PHE354B, PHE354D, PHE410B, PHE410D, PHE435B, PHE435D, PRO249B, PRO249D, PRO250B, PRO250D, PRO288B, PRO288D, PRO347B, PRO347D, PRO433B, PRO433D, PRO436B, PRO436D, PRO450B, PRO450D, SER232B, SER232D, SER282B, SER282D, SER437B, SER437D, SER488B, SER488D, SER500B, SER500D, SER502B, SER502D, THR239B, THR239D, THR281B, THR281D, THR292B, THR292D, THR353B, THR353D, THR443B, THR443D, THR454B, THR454D, THR487B, THR487D, THR489B, THR489D, THR499B, THR499D, TRP424B, TRP424D, TRP427B, TRP427D, TYR242B, TYR242D, TYR243B, TYR243D, TYR244B, TYR244D, TYR298B, TYR298D, TYR420B, TYR420D, TYR490B, TYR490D, TYR501B, TYR501D, VAL289B, VAL289D, VAL387B, VAL387D, VAL409B, VAL409D, VAL426B, VAL426D, VAL441B, VAL441D, VAL447B, VAL447D, VAL452B, VAL452D, VAL483B, VAL483D, VAL491B, VAL491D
• C-D: ARG144C, ARG144D, ARG484C, ARG484D, ASP70C, ASP70D, GLU143C, GLU143D, GLU486C, GLU486D, GLU68C, GLU68D, GLU72D, GLY492C, GLY492D, GLY71C, GLY71D, ILE142C, ILE142D, ILE69C, ILE69D, LYS74C, LYS74D, PHE76C, PHE76D, PHE79C, PHE79D, PRO75C, SER488C, SER488D, THR489C, THR489D, TYR490C, TYR490D, TYR77C, TYR77D, VAL491C, VAL491D, VAL67C, VAL67D
• C-E: ALA183C, ALA216C, ALA216E, ARG131E, ARG151C, ARG184C, ARG184E, ARG218E, ARG219C, ARG219E, ARG265E, ASP190C, ASP210E, ASP223C, ASP311C, CYS215C, CYS215E, GLN173E, GLN194C, GLN266E, GLU148C, GLU180E, GLU217E, HIS192C, HIS213E, HIS271C, HIS271E, HIS275C, ILE147C, LEU154C, LEU193C, LEU212E, LEU272C, LEU272E, LYS177E, LYS187C, PHE176E, PHE214E, PHE224C, PHE269C, PHE269E, PRO191C, PRO221C, PRO221E, PRO268C, PRO268E, PRO270E, PRO273C, SER188C, SER188E, SER267E, THR209E, VAL186C, VAL189C, VAL195C, VAL220C, VAL220E, VAL222C, VAL222E
• D-E: ALA262D, ARG11D, ARG11E, ARG261D, ARG265D, ARG365E, ARG373E, ARG374E, ASN17D, ASN9D, ASN9E, ASP308D, ASP308E, ASP311D, ASP360E, GLN266D, GLU12D, GLU12E, GLU305E, GLU361E, GLY10E, GLY307D, GLY377E, HIS271D, LEU362E, LYS13D, LYS13E, LYS15D, LYS15E, LYS258D, LYS258E, LYS375E, PRO270D, SER405E, SER8E, TYR309D, TYR309E, VAL310D
• D-F: ALA216D, ARG151F, ARG184D, ARG218D, ARG219D, ARG219F, ASP190F, CYS215D, GLU217D, HIS192F, ILE147F, LEU193F, LYS187F, PHE269D, PRO191F, PRO221D, SER188F, VAL189F, VAL220D
• E-F: ARG144E, ARG144F, ARG484E, ARG484F, ASP70E, ASP70F, GLU143E, GLU143F, GLU486E, GLU486F, GLU68E, GLU68F, GLY492E, GLY492F, HIS140E, HIS140F, ILE142E, ILE142F, ILE69E, ILE69F, LYS74E, LYS74F, PHE76E, PHE76F, PHE79E, PHE79F, PRO75F, SER139E, SER139F, SER488E, SER488F, THR489E, THR489F, TYR490E, TYR490F, TYR77E, TYR77F, VAL491E, VAL491F, VAL67E, VAL67F
• E-G: ALA293E, ALA293G, ALA296E, ALA296G, ALA297E, ALA297G, ALA330E, ALA330G, ALA408E, ALA408G, ALA423E, ALA423G, ALA440E, ALA440G, ALA448E, ALA448G, ARG374E, ARG374G, ARG413E, ARG413G, ARG425E, ARG425G, ARG432E, ARG432G, ARG434E, ARG434G, ARG445E, ARG445G, ARG457E, ARG457G, ARG458G, ARG484E, ARG484G, ASN287E, ASN287G, ASN295E, ASN295G, ASN417E, ASN417G, ASN422E, ASN422G, ASN473E, ASN473G, ASP291E, ASP291G, ASP376G, ASP485E, ASP485G, ASP494E, ASP494G, ASP495E, ASP495G, GLN245E, GLN245G, GLN414E, GLN414G, GLN419E, GLN419G, GLN429E, GLN429G, GLN439E, GLN439G, GLN446E, GLN446G, GLN449E, GLN449G, GLN456E, GLN456G, GLN482E, GLN482G, GLU241E, GLU241G, GLU246E, GLU246G, GLU248E, GLU248G, GLU389E, GLU389G, GLU392E, GLU392G, GLU418E, GLU418G, GLU442E, GLU442G, GLU455E, GLU455G, GLU479E, GLU479G, GLU481E, GLU481G, GLU486E, GLU486G, GLU497E, GLU497G, GLY334E, GLY334G, GLY391E, GLY391G, GLY431E, GLY431G, GLY492E, GLY492G, GLY496E, GLY496G, HIS236E, HIS236G, HIS290E, HIS290G, HIS333E, HIS333G, HIS350E, HIS451E, HIS451G, ILE411E, ILE411G, ILE415E, ILE415G, ILE498E, ILE498G, LEU247E, LEU247G, LEU294E, LEU294G, LEU331E, LEU331G, LEU386E, LEU386G, LEU394E, LEU394G, LEU444E, LEU444G, LEU477E, LEU477G, LEU493E, LEU493G, LYS233E, LYS237E, LYS237G, LYS238E, LYS238G, LYS329E, LYS329G, LYS390E, LYS390G, LYS412E, LYS412G, LYS428E, LYS428G, LYS45E, LYS45G, LYS472E, LYS472G, MET388E, MET388G, MET430E, MET430G, MET453E, MET453G, PHE240E, PHE240G, PHE332E, PHE332G, PHE354E, PHE354G, PHE410E, PHE410G, PHE435E, PHE435G, PRO249E, PRO249G, PRO250E, PRO250G, PRO288E, PRO288G, PRO347E, PRO347G, PRO433E, PRO433G, PRO436E, PRO436G, PRO450E, PRO450G, SER232E, SER232G, SER282E, SER282G, SER437E, SER437G, SER488E, SER488G, SER500E, SER500G, SER502E, SER502G, THR239E, THR239G, THR281E, THR281G, THR292E, THR292G, THR353E, THR353G, THR443E, THR443G, THR454E, THR454G, THR487E, THR487G, THR489E, THR489G, THR499E, THR499G, TRP424E, TRP424G, TRP427E, TRP427G, TYR242E, TYR242G, TYR243E, TYR243G, TYR244E, TYR244G, TYR298E, TYR298G, TYR420E, TYR420G, TYR490E, TYR490G, TYR501E, TYR501G, VAL289E, VAL289G, VAL387E, VAL387G, VAL409E, VAL409G, VAL426E, VAL426G, VAL441E, VAL447E, VAL447G, VAL452E, VAL452G, VAL483E, VAL483G, VAL491E, VAL491G
• E-H: ALA30E, ALA30H, ALA330E, ALA330H, ALA340E, ALA440E, ALA440H, ALA91E, ALA91H, ARG144E, ARG144H, ARG26E, ARG26H, ARG434E, ARG434H, ARG438E, ARG438H, ARG65E, ARG65H, ARG84E, ARG84H, ASN78E, ASN78H, ASP320E, ASP320H, ASP326E, ASP326H, ASP37E, ASP37H, ASP59E, ASP59H, ASP60E, ASP60H, ASP70E, ASP70H, ASP83E, ASP83H, ASP87E, ASP87H, GLN32E, GLN32H, GLN439E, GLN439H, GLU143E, GLU143H, GLU241E, GLU241H, GLU323E, GLU323H, GLU34E, GLU34H, GLU66E, GLU66H, GLU68E, GLU68H, GLU72E, GLU72H, GLY28E, GLY28H, GLY62E, GLY62H, HIS140E, HIS140H, HIS333E, HIS333H, HIS342E, HIS342H, HIS38E, HIS38H, ILE63E, ILE63H, ILE69E, ILE69H, ILE82E, ILE82H, ILE85H, LEU29E, LEU29H, LEU31E, LEU31H, LEU331E, LEU331H, LEU341E, LEU341H, LEU36E, LEU36H, LEU90E, LEU90H, LEU92E, LEU92H, LYS105E, LYS105H, LYS118E, LYS118H, LYS238E, LYS238H, LYS329E, LYS329H, LYS33E, LYS33H, LYS40E, LYS40H, LYS74E, LYS74H, MET325E, MET325H, MET73E, MET73H, PHE240E, PHE240H, PHE322E, PHE322H, PHE435E, PHE435H, PHE76E, PHE76H, PHE79E, PHE79H, PRO328E, PRO328H, PRO433E, PRO433H, PRO436E, PRO436H, PRO75E, PRO75H, SER319E, SER319H, SER343E, SER343H, SER437E, SER437H, SER58E, SER88E, SER88H, THR239E, THR239H, THR80E, THR80H, TYR116E, TYR116H, TYR145E, TYR145H, TYR35E, TYR35H, TYR64E, TYR64H, TYR77E, TYR77H, TYR81E, TYR81H, VAL321E, VAL321H, VAL327E, VAL327H, VAL441E, VAL441H, VAL61E, VAL61H, VAL67E, VAL67H, VAL86E
• F-G: ALA30F, ALA30G, ALA330F, ALA330G, ALA340F, ALA340G, ALA440F, ALA440G, ALA91F, ALA91G, ARG144F, ARG144G, ARG26F, ARG26G, ARG434F, ARG434G, ARG438F, ARG438G, ARG65F, ARG65G, ARG84F, ARG84G, ASN78F, ASN78G, ASP320F, ASP320G, ASP326F, ASP326G, ASP37F, ASP37G, ASP59F, ASP59G, ASP60F, ASP60G, ASP70F, ASP70G, ASP83F, ASP83G, ASP87F, ASP87G, GLN32F, GLN32G, GLN439F, GLN439G, GLU143F, GLU143G, GLU241F, GLU241G, GLU323F, GLU323G, GLU34F, GLU34G, GLU66F, GLU66G, GLU68F, GLU68G, GLU72G, GLY28F, GLY28G, GLY62F, GLY62G, HIS140F, HIS140G, HIS333F, HIS333G, HIS342F, HIS342G, HIS38F, HIS38G, ILE63F, ILE63G, ILE69F, ILE69G, ILE82F, ILE82G, ILE85F, LEU29F, LEU29G, LEU31F, LEU31G, LEU331F, LEU331G, LEU341F, LEU341G, LEU36F, LEU36G, LEU90F, LEU90G, LEU92F, LEU92G, LYS105F, LYS105G, LYS118F, LYS118G, LYS238F, LYS238G, LYS329F, LYS329G, LYS33F, LYS33G, LYS40F, LYS74F, LYS74G, MET325F, MET325G, MET73F, MET73G, PHE240F, PHE240G, PHE322F, PHE322G, PHE435F, PHE435G, PHE76F, PHE76G, PHE79F, PHE79G, PRO328F, PRO328G, PRO433F, PRO433G, PRO436F, PRO436G, PRO75F, SER319F, SER319G, SER343F, SER343G, SER437F, SER437G, SER58F, SER88F, SER88G, THR239F, THR239G, THR80F, THR80G, TYR116F, TYR116G, TYR145F, TYR145G, TYR35F, TYR35G, TYR64F, TYR64G, TYR77F, TYR77G, TYR81F, TYR81G, VAL321F, VAL321G, VAL327F, VAL327G, VAL441F, VAL441G, VAL61F, VAL61G, VAL67F, VAL67G
• F-H: ALA293F, ALA293H, ALA296F, ALA296H, ALA297F, ALA297H, ALA330F, ALA330H, ALA408F, ALA408H, ALA423F, ALA423H, ALA440F, ALA440H, ALA448F, ALA448H, ARG374F, ARG374H, ARG413F, ARG413H, ARG425F, ARG425H, ARG432F, ARG432H, ARG434F, ARG434H, ARG445F, ARG445H, ARG457F, ARG457H, ARG458F, ARG458H, ARG484F, ARG484H, ASN287F, ASN287H, ASN295F, ASN295H, ASN417F, ASN417H, ASN422F, ASN422H, ASN473F, ASN473H, ASP291F, ASP291H, ASP376F, ASP376H, ASP485F, ASP485H, ASP494F, ASP494H, ASP495F, ASP495H, GLN245F, GLN245H, GLN414F, GLN414H, GLN419F, GLN419H, GLN429F, GLN429H, GLN439F, GLN439H, GLN446F, GLN446H, GLN449F, GLN449H, GLN456F, GLN456H, GLN482F, GLN482H, GLU241F, GLU241H, GLU246F, GLU246H, GLU248F, GLU248H, GLU389F, GLU389H, GLU392F, GLU392H, GLU418F, GLU418H, GLU442F, GLU442H, GLU455F, GLU455H, GLU479F, GLU479H, GLU481F, GLU481H, GLU486F, GLU486H, GLU497F, GLU497H, GLY334F, GLY334H, GLY391F, GLY391H, GLY431F, GLY431H, GLY492F, GLY492H, GLY496F, GLY496H, HIS236F, HIS236H, HIS290F, HIS290H, HIS333F, HIS333H, HIS350F, HIS451F, HIS451H, ILE411F, ILE411H, ILE415F, ILE415H, ILE498F, ILE498H, LEU247F, LEU247H, LEU294F, LEU294H, LEU331F, LEU331H, LEU386F, LEU386H, LEU394F, LEU394H, LEU444F, LEU444H, LEU477F, LEU493F, LEU493H, LYS233F, LYS237F, LYS237H, LYS238F, LYS238H, LYS329F, LYS329H, LYS390F, LYS390H, LYS412F, LYS412H, LYS428F, LYS428H, LYS45F, LYS45H, LYS472F, LYS472H, MET388F, MET388H, MET430F, MET430H, MET453F, MET453H, PHE240F, PHE240H, PHE332F, PHE332H, PHE354F, PHE354H, PHE410F, PHE410H, PHE435F, PHE435H, PRO249F, PRO249H, PRO250F, PRO250H, PRO288F, PRO288H, PRO347F, PRO347H, PRO433F, PRO433H, PRO436F, PRO436H, PRO450F, PRO450H, SER232F, SER232H, SER282F, SER282H, SER378F, SER437F, SER437H, SER488F, SER488H, SER500F, SER500H, SER502F, SER502H, THR239F, THR239H, THR281F, THR281H, THR292F, THR292H, THR353F, THR353H, THR443F, THR443H, THR454F, THR454H, THR487F, THR487H, THR489F, THR489H, THR499F, THR499H, TRP424F, TRP424H, TRP427F, TRP427H, TYR242F, TYR242H, TYR243F, TYR243H, TYR244F, TYR244H, TYR298F, TYR298H, TYR420F, TYR420H, TYR490F, TYR490H, TYR501F, TYR501H, VAL289F, VAL289H, VAL387F, VAL387H, VAL409F, VAL409H, VAL426F, VAL426H, VAL441F, VAL441H, VAL447F, VAL447H, VAL452F, VAL452H, VAL483F, VAL483H, VAL491F, VAL491H
• G-H: ARG144H, ARG484G, ARG484H, ASP70G, ASP70H, GLU143G, GLU143H, GLU148H, GLU486G, GLU486H, GLU68G, GLU68H, GLY492G, GLY492H, ILE142G, ILE142H, ILE69G, ILE69H, LYS375G, LYS74G, LYS74H, PHE76G, PHE76H, PHE79G, PHE79H, PRO75H, SER488G, SER488H, THR489G, THR489H, TYR490G, TYR490H, TYR77G, TYR77H, VAL491G, VAL491H, VAL67G, VAL67H