2BEX

crystal structure of placental ribonuclease inhibitor in complex with human eosinophil derived neurotoxin at 2a resolution

• Total interactions analyzed: 6
• Total true interactions: 5
• Strongest Interaction:
  • Chains: A-C
  • Int. Res.: 176
  • Norm. En. per Res.: -4.191
• Hub Node: A(3)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-5.2884	6.0059	-30.2757	-29.5581	84	7	0	2498	3	39	40
A-C	-137.2121	-121.8232	-478.582	-737.6173	176	29	1	17365	9	50	23
A-D	-18.0212	0.0	-30.5644	-48.5856	21	2	0	1088	0	5	2
B-C	-11.7464	0.0	-59.1498	-70.8962	41	1	1	3196	0	13	7
B-D	-111.5086	-134.2951	-376.769	-622.5727	160	16	1	13721	9	47	21

Interface residues

• A-B: ALA326A, ALA327A, ALA337A, ALA390A, ALA391A, ALA395A, ALA56B, ALA58B, ARG229B, ARG258B, ARG301A, ARG33B, ARG351A, ARG358A, ARG372B, ARG400B, ARG457B, ASN349A, ASP297A, ASP378A, ASP380A, ASP8B, CYS29B, CYS361A, GLN115B, GLN30B, GLN338A, GLN362A, GLN366A, GLN416A, GLN423A, GLN430B, GLN5B, GLN87B, GLU116B, GLU144B, GLU173B, GLU201B, GLU294A, GLU298A, GLU305A, GLU315B, GLU353A, GLU401B, GLU419A, GLU429B, GLU59B, GLY296A, GLY363A, GLY365A, HIS331A, HIS397A, ILE4B, LEU343B, LEU394A, LEU415A, LEU427B, LEU456B, LEU7B, LYS145B, LYS172B, LYS286B, LYS88B, PRO367A, PRO424B, PRO454B, SER227B, SER321A, SER323A, SER330A, SER333A, SER334A, SER387A, SER388A, SER398B, SER420A, SER455B, SER6B, THR325A, THR392A, VAL31B, VAL32B, VAL370B, VAL373B
• A-C: ALA110C, ALA232A, ALA26C, ALA291A, ALA377A, ALA448A, ALA99C, ARG118C, ARG132C, ARG33A, ARG351A, ARG35C, ARG36C, ARG372A, ARG445A, ARG457A, ARG63A, ARG68C, ARG97C, ASN113C, ASN122A, ASN178A, ASN25C, ASN31C, ASN32C, ASN349A, ASN350A, ASN39C, ASN406A, ASN407A, ASN41C, ASN61A, ASN65C, ASN70C, ASN84C, ASN92C, ASN93A, ASN95C, ASP112C, ASP121A, ASP131C, ASP35A, ASP36A, ASP378A, ASP380A, ASP383A, ASP403A, ASP411A, ASP435A, ASP444A, ASP8A, CYS111C, CYS11A, CYS23C, CYS379A, CYS37C, CYS408A, CYS62C, CYS83C, CYS94A, CYS96C, GLN100C, GLN10A, GLN147A, GLN14C, GLN21C, GLN22C, GLN28C, GLN346A, GLN34C, GLN40C, GLN430A, GLN447A, GLN92A, GLU12A, GLU149A, GLU173A, GLU206A, GLU230A, GLU264A, GLU287A, GLU344A, GLU401A, GLU440A, GLU443A, GLU450A, GLU59A, GLU66A, GLY234A, GLY292A, GLY410A, HIS118A, HIS129C, HIS15C, HIS82C, ILE30C, ILE347A, ILE414A, ILE436A, ILE459A, ILE93C, ILE9A, LEU123A, LEU130C, LEU148A, LEU205A, LEU374A, LEU376A, LEU402A, LEU404A, LEU409A, LEU431A, LEU433A, LEU446A, LEU449A, LEU85C, LYS1C, LYS204A, LYS320A, LYS38C, LYS66C, MET0C, MET27C, MET442A, PHE11C, PHE5C, PRO127C, PRO2C, PRO3C, PRO88C, PRO90C, SER120A, SER177A, SER207A, SER20C, SER235A, SER289A, SER316A, SER321A, SER348A, SER382A, SER405A, SER439A, SER460A, SER64A, SER64C, SER89C, SER94C, THR101C, THR175A, THR19C, THR24C, THR259A, THR42C, THR6C, THR86C, THR87C, TRP10C, TRP261A, TRP263A, TRP318A, TRP375A, TRP438A, TRP7C, TYR150A, TYR33C, TYR434A, TYR437A, TYR98C, VAL126C, VAL128C, VAL176A, VAL29C, VAL373A, VAL432A, VAL458A
• A-D: ALA326A, ALA355A, ARG358A, ARG35D, ASN92D, ASP354A, CYS329A, CYS361A, GLN362A, GLN91D, GLU359A, GLY356A, ILE93D, LEU360A, PRO90D, SER330A, SER384A, SER385A, SER388A, SER89D, VAL357A
• B-C: ALA17B, ARG132C, ARG18B, ARG68C, ASN59C, ASN65C, ASP131C, ASP8B, CYS29B, CYS62C, CYS71C, GLN27B, GLN28B, GLN30B, GLN5B, GLN77C, GLU12B, GLU21B, HIS73C, ILE108C, ILE133C, ILE134C, ILE4B, ILE9B, LEU22B, LEU25B, LEU26B, LEU7B, LYS66C, LYS69C, MET105C, MET60C, PHE106C, PRO24B, PRO58C, PRO63C, SER64C, SER6B, THR61C, VAL31B, VAL32B
• B-D: ALA110D, ALA232B, ALA291B, ALA377B, ALA448B, ALA99D, ARG132D, ARG33B, ARG35D, ARG36D, ARG445B, ARG457B, ARG63B, ARG68D, ARG97D, ASN113D, ASN178B, ASN25D, ASN31D, ASN32D, ASN349B, ASN350B, ASN39D, ASN406B, ASN407B, ASN41D, ASN65D, ASN70D, ASN84D, ASN92D, ASN93B, ASN95D, ASP112D, ASP121B, ASP131D, ASP35B, ASP36B, ASP378B, ASP380B, ASP403B, ASP411B, ASP435B, ASP444B, CYS111D, CYS11B, CYS23D, CYS379B, CYS37D, CYS408B, CYS62D, CYS83D, CYS96D, GLN100D, GLN10B, GLN147B, GLN14D, GLN21D, GLN22D, GLN28D, GLN346B, GLN34D, GLN40D, GLN430B, GLN447B, GLN91D, GLN92B, GLU149B, GLU206B, GLU230B, GLU264B, GLU287B, GLU344B, GLU401B, GLU440B, GLU443B, GLU450B, GLY234B, GLY292B, GLY410B, HIS118B, HIS129D, HIS15D, ILE30D, ILE347B, ILE414B, ILE436B, ILE459B, ILE93D, LEU123B, LEU130D, LEU374B, LEU376B, LEU402B, LEU404B, LEU409B, LEU431B, LEU433B, LEU446B, LEU449B, LEU456B, LEU85D, LYS1D, LYS204B, LYS320B, LYS38D, LYS66D, MET0D, MET27D, MET442B, PHE11D, PHE5D, PRO127D, PRO2D, PRO3D, PRO63D, PRO88D, PRO90D, SER120B, SER177B, SER207B, SER20D, SER235B, SER289B, SER316B, SER321B, SER348B, SER382B, SER405B, SER439B, SER460B, SER64B, SER64D, SER89D, SER94D, THR101D, THR175B, THR24D, THR259B, THR42D, THR67D, THR86D, THR87D, TRP10D, TRP261B, TRP263B, TRP318B, TRP375B, TRP438B, TRP7D, TYR150B, TYR33D, TYR434B, TYR437B, TYR98D, VAL126D, VAL128D, VAL29D, VAL373B, VAL432B, VAL458B