2BE6

2.0 a crystal structure of the cav1.2 iq domain-ca/cam complex

• Total interactions analyzed: 15
• Total true interactions: 7
• Strongest Interaction:
  • Chains: C-F
  • Int. Res.: 111
  • Norm. En. per Res.: -5.1924
• Hub Node: A(3)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-D	-35.4909	-105.0803	-409.862	-550.4332	115	23	12	16681	9	60	31
A-E	0.0	0.0	-0.0071	-0.0071	4	0	0	4	0	0	2
A-C	-9.6609	-3.1394	-60.2745	-73.0747	39	2	0	2208	0	17	19
D-C	0.0	0.0	-0.0241	-0.0241	3	0	0	9	0	1	0
B-E	0.0	-3.1236	-209.436	-212.5596	78	5	6	9410	0	14	13
B-C	-11.2345	-24.0771	-68.1215	-103.4331	42	3	0	2863	2	12	19
C-F	-42.283	-162.6754	-371.397	-576.3554	111	19	12	16070	12	56	26

Interface residues

• A-D: ALA10A, ALA128A, ALA15A, ALA1620D, ALA73A, ALA88A, ARG106A, ARG126A, ARG1629D, ARG1634D, ARG74A, ARG86A, ARG90A, ASN111A, ASN137A, ASN42A, ASN53A, ASP122A, ASP129A, ASP50A, ASP56A, ASP93A, GLN143A, GLN1625D, GLN41A, GLN8A, GLU104A, GLU114A, GLU119A, GLU11A, GLU120A, GLU123A, GLU127A, GLU140A, GLU14A, GLU1612D, GLU1626D, GLU47A, GLU54A, GLU7A, GLU82A, GLU83A, GLU84A, GLU87A, GLY113A, GLY1616D, HIS107A, ILE100A, ILE125A, ILE1624D, ILE27A, ILE52A, ILE63A, ILE85A, ILE9A, LEU105A, LEU112A, LEU116A, LEU1623D, LEU1639D, LEU18A, LEU32A, LEU39A, LEU48A, LYS115A, LYS13A, LYS1617D, LYS1630D, LYS1632D, LYS1635D, LYS75A, LYS77A, MET109A, MET124A, MET144A, MET145A, MET36A, MET51A, MET71A, MET72A, MET76A, PHE12A, PHE141A, PHE1618D, PHE1622D, PHE1628D, PHE1631D, PHE16A, PHE19A, PHE68A, PHE89A, PHE92A, PRO43A, SER17A, SER38A, SER81A, THR110A, THR117A, THR146A, THR1614D, THR1621D, THR28A, THR29A, TYR1619D, TYR1627D, VAL108A, VAL121A, VAL136A, VAL142A, VAL1613D, VAL1615D, VAL1640D, VAL35A, VAL55A, VAL91A
• A-E: ASP50A, GLU1612E, GLU54A, VAL1613E
• A-C: ALA46C, ALA57C, ALA73C, ARG74C, ARG86A, ARG90A, ASN42A, ASN53C, ASN60C, ASN97A, ASP50C, ASP56C, ASP58C, ASP93A, ASP95A, GLN41A, GLN49C, GLU104A, GLU45A, GLU47A, GLU47C, GLU54C, GLU67C, GLU83A, GLU87A, GLY40A, GLY59C, GLY61C, GLY96A, GLY98A, ILE52C, LYS75C, LYS94A, MET51C, PRO43A, THR44A, THR70C, TYR99A, VAL55C
• D-C: ALA57C, ARG74C, LYS1617D
• B-E: ALA10B, ALA15B, ALA1620E, ALA73B, ALA88B, ARG74B, ARG86B, ARG90B, ASN42B, ASN53B, ASP50B, ASP56B, ASP78B, GLN1625E, GLN41B, GLN8B, GLU114B, GLU11B, GLU14B, GLU1612E, GLU47B, GLU54B, GLU7B, GLU82B, GLU83B, GLU84B, GLU87B, GLY1616E, ILE1624E, ILE27B, ILE52B, ILE63B, ILE85B, ILE9B, LEU105B, LEU112B, LEU1623E, LEU18B, LEU32B, LEU39B, LEU48B, LYS13B, LYS1617E, LYS21B, LYS75B, LYS77B, MET109B, MET144B, MET145B, MET36B, MET51B, MET71B, MET72B, MET76B, PHE12B, PHE141B, PHE1618E, PHE1622E, PHE16B, PHE19B, PHE68B, PHE89B, PHE92B, PRO43B, SER38B, THR146B, THR1614E, THR1621E, THR28B, THR29B, TYR1619E, VAL108B, VAL142B, VAL1613E, VAL1615E, VAL35B, VAL55B, VAL91B
• B-C: ALA10C, ALA46B, ARG37B, ARG90B, ASN111B, ASN42B, ASN60C, ASN97B, ASP58C, ASP64C, ASP93B, ASP95B, GLN41B, GLN8C, GLU104B, GLU45B, GLU47B, GLU67C, GLU6C, GLU7C, GLY25C, GLY40B, GLY96B, HIS107B, ILE9C, LEU39B, LEU4C, LEU69C, LYS13C, LYS94B, MET36B, PHE65C, PHE92B, PRO43B, PRO66C, SER38B, THR26C, THR44B, THR5C, THR70C, VAL108B, VAL91B
• C-F: ALA10C, ALA128C, ALA15C, ALA1620F, ALA73C, ALA88C, ARG106C, ARG126C, ARG1629F, ARG1634F, ARG37C, ARG74C, ARG86C, ARG90C, ASN111C, ASN42C, ASN53C, ASP122C, ASP129C, ASP20C, ASP50C, GLN1625F, GLN41C, GLN8C, GLU104C, GLU114C, GLU119C, GLU11C, GLU120C, GLU123C, GLU127C, GLU140C, GLU14C, GLU1626F, GLU31C, GLU47C, GLU54C, GLU7C, GLU82C, GLU83C, GLU84C, GLU87C, GLY113C, GLY1616F, GLY33C, HIS107C, ILE100C, ILE125C, ILE1624F, ILE27C, ILE52C, ILE63C, ILE85C, LEU105C, LEU112C, LEU116C, LEU1623F, LEU18C, LEU32C, LEU39C, LEU48C, LYS115C, LYS13C, LYS1617F, LYS1630F, LYS1632F, LYS1633F, LYS1635F, LYS21C, LYS75C, LYS94C, MET109C, MET124C, MET144C, MET145C, MET36C, MET51C, MET71C, MET72C, PHE12C, PHE141C, PHE1618F, PHE1622F, PHE1628F, PHE1631F, PHE16C, PHE19C, PHE65C, PHE68C, PHE89C, PHE92C, PRO43C, SER17C, SER38C, THR110C, THR117C, THR146C, THR1621F, THR28C, THR29C, THR34C, TYR1619F, TYR1627F, VAL108C, VAL121C, VAL136C, VAL142C, VAL1615F, VAL35C, VAL55C, VAL91C