2BBZ

crystal structure of mc159 reveals molecular mechanism of disc assembly and vflip inhibition

• Total interactions analyzed: 6
• Total true interactions: 6
• Strongest Interaction:
  • Chains: B-C
  • Int. Res.: 51
  • Norm. En. per Res.: -3.0572
• Hub Node: A(3)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-5.8968	-21.8721	-125.929	-153.6979	75	17	4	5916	1	4	10
A-C	-36.3656	9.9002	-83.4487	-109.9141	60	33	2	5288	1	20	20
A-D	-12.5265	-50.6905	-87.084	-150.3011	51	10	2	4682	4	23	18
B-C	-15.4558	-54.5612	-85.8981	-155.9151	51	13	2	4824	5	23	18
B-D	0.0	0.0	-29.8311	-29.8311	31	11	3	2181	0	8	4
C-D	-2.5739	-23.5162	-122.188	-148.2781	75	31	5	6436	0	5	10

Interface residues

• A-B: ALA119B, ALA158B, ALA182A, ALA182B, ALA189A, ALA189B, ALA190A, ALA190B, ARG162A, ARG162B, ARG183A, ARG185A, ARG185B, ASN121A, ASN121B, ASN123A, ASN123B, ASP159A, ASP159B, CYS120B, CYS170B, CYS187A, CYS187B, GLN178A, GLN181A, GLN181B, GLU177A, GLU177B, GLU180A, GLY147A, GLY147B, LEU117B, LEU122A, LEU122B, LEU148A, LEU148B, LEU157A, LEU157B, LEU161B, LEU164B, MET160A, MET160B, PHE118A, PHE118B, PRO124A, PRO124B, PRO151A, PRO151B, SER150A, SER150B, SER152A, SER152B, SER153A, SER153B, SER155A, SER155B, SER191A, SER191B, THR163A, THR163B, TYR184A, TYR184B, TYR186A, TYR186B, TYR188A, TYR188B, VAL146A, VAL146B, VAL149A, VAL149B, VAL154A, VAL154B, VAL156A, VAL156B, VAL174B
• A-C: ALA158A, ALA158C, ALA182A, ALA182C, ARG162A, ARG162C, ARG165A, ARG165C, ARG166A, ARG166C, ARG183C, ARG185A, ARG185C, ASP159A, ASP159C, ASP168A, ASP168C, CYS170A, CYS170C, GLN171A, GLN171C, GLN172A, GLN172C, GLN178A, GLN178C, GLN179A, GLN179C, GLN181A, GLN181C, GLU175A, GLU175C, GLU177A, GLU177C, GLU180A, GLU180C, LEU164A, LEU164C, LEU167A, LEU167C, LEU169A, LEU169C, LEU173A, LEU173C, SER152A, SER152C, SER153A, SER153C, SER155A, SER155C, TYR176A, TYR176C, TYR184C, TYR186A, TYR186C, VAL154A, VAL154C, VAL156A, VAL156C, VAL174A, VAL174C
• A-D: ALA114A, ALA158D, ARG113A, ARG116A, ARG162A, ARG162D, ARG165A, ARG165D, ARG166A, ARG166D, ASN121A, ASP108A, ASP159A, ASP159D, ASP168A, ASP168D, CYS170D, GLN171D, GLN172D, GLN178D, GLN181D, GLU111A, GLU175D, GLU177D, LEU112A, LEU115A, LEU117A, LEU122A, LEU157D, LEU161A, LEU161D, LEU164A, LEU167A, LEU167D, LEU169D, LEU173D, MET160A, MET160D, PHE118A, SER109A, SER110A, SER153D, SER155D, THR163A, THR163D, TYR176D, TYR186D, VAL154D, VAL156A, VAL156D, VAL174D
• B-C: ALA114C, ALA158B, ARG113C, ARG116C, ARG162B, ARG162C, ARG165B, ARG165C, ARG166B, ARG166C, ASN121C, ASP108C, ASP159B, ASP159C, ASP168B, ASP168C, CYS170B, GLN171B, GLN172B, GLN178B, GLN181B, GLU111C, GLU175B, GLU177B, LEU112C, LEU115C, LEU117C, LEU122C, LEU157B, LEU161B, LEU161C, LEU164C, LEU167B, LEU167C, LEU169B, LEU173B, MET160B, MET160C, PHE118C, SER109C, SER110C, SER153B, SER155B, THR163B, THR163C, TYR176B, TYR186B, VAL154B, VAL156B, VAL156C, VAL174B
• B-D: ALA182B, ALA182D, ALA189B, ALA189D, ALA190B, ALA190D, ARG183B, ARG183D, ARG185B, ARG185D, ARG95B, ARG95D, CYS187B, CYS187D, GLN178B, GLN178D, GLN179B, GLN179D, GLN181B, GLN181D, GLU175B, GLU175D, GLU177B, GLU177D, GLU180B, GLU180D, SER191B, SER191D, TYR184D, TYR186B, TYR186D
• C-D: ALA119D, ALA158C, ALA158D, ALA182C, ALA182D, ALA189C, ALA189D, ALA190C, ALA190D, ARG162C, ARG162D, ARG183C, ARG185C, ARG185D, ASN121C, ASN121D, ASN123C, ASN123D, ASP159C, ASP159D, CYS120D, CYS170D, CYS187C, CYS187D, GLN178C, GLN181C, GLN181D, GLU177C, GLU177D, GLU180C, GLY147C, GLY147D, LEU117D, LEU122C, LEU122D, LEU148C, LEU148D, LEU157C, LEU157D, LEU161D, LEU164D, MET160C, MET160D, PHE118C, PHE118D, PRO124C, PRO124D, PRO151C, PRO151D, SER150C, SER150D, SER152C, SER152D, SER153C, SER153D, SER155C, SER155D, SER191C, SER191D, THR163D, TYR184C, TYR184D, TYR186C, TYR186D, TYR188C, TYR188D, VAL146C, VAL146D, VAL149C, VAL149D, VAL154C, VAL154D, VAL156C, VAL156D, VAL174D