2B9V

acetobacter turbidans alpha-amino acid ester hydrolase

• Total interactions analyzed: 120
• Total true interactions: 33
• Strongest Interaction:
  • Chains: B-D
  • Int. Res.: 167
  • Norm. En. per Res.: -3.9588
• Hub Node: F(5)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-34.4186	-87.4193	-155.829	-277.6669	93	3	0	5640	10	50	53
A-C	-72.3583	-76.2045	-449.918	-598.4808	165	12	8	17806	7	34	30
A-D	-33.9701	-94.5305	-321.435	-449.9356	139	18	3	12589	5	67	75
B-C	-33.0315	-97.6932	-317.23	-447.9547	138	15	3	12479	5	67	76
B-D	-87.4199	-78.8653	-494.835	-661.1202	167	15	8	18925	7	34	32
B-L	-8.7008	11.3893			10
C-D	-14.633	-91.8995	-149.442	-255.9745	91	0	0	5354	10	47	52
D-L	-10.5228	0.0			4
E-F	-18.827	-83.4305	-146.322	-248.5795	92	1	0	5302	10	48	52
E-G	-89.4567	-70.3034	-462.45	-622.2101	168	9	8	18242	6	34	32
E-H	-36.0613	-96.7612	-323.902	-456.7245	138	14	3	12535	4	67	76
E-M	0.0	-5.876			3
F-G	-27.9028	-95.9187	-306.279	-430.1005	137	18	3	12223	4	67	75
F-H	-73.4232	-75.0118	-432.94	-581.375	164	14	8	17514	8	34	30
F-I	0.0	0.0	-0.5221	-0.5221	7	0	0	142	0	2	2
F-K	0.0	0.0	-0.2855	-0.2855	6	0	0	103	0	2	0
F-L	0.0	-1.2645			3
G-H	-32.3312	-83.0204	-156.091	-271.4427	92	4	0	5528	11	48	52
G-M	0.0	4.9203			6
H-I	0.0	11.692	-14.515	-2.823	24	0	0	1006	0	5	4
H-K	-9.125	-32.5522	-119.662	-161.3392	74	9	0	5690	2	17	21
I-J	-31.3194	-79.8244	-154.573	-265.7168	95	6	0	5566	10	48	52
I-K	-73.2769	-76.3987	-473.901	-623.5766	169	12	8	18359	8	35	31
I-L	-36.8171	-96.3935			27
J-K	-37.5294	-101.3356	-55.5218	-194.3868	57	2	1	2136	0	14	19
J-L	-95.1226	-81.3958			16
K-L	-18.0357	-94.0877			21
M-N	-35.4033	-93.2259			22
M-O	-80.2568	-79.908			14
M-P	-27.7517	-106.4191			25
N-O	-35.0444	-106.1326			26
N-P	-54.2483	-76.4339			14
O-P	-26.3942	-85.5133			21

Interface residues

• A-B: ALA124A, ALA124B, ALA553A, ALA553B, ALA607B, ARG120A, ARG120B, ARG128A, ARG128B, ARG394A, ARG394B, ARG395A, ARG395B, ASN376A, ASN376B, ASP135A, ASP135B, ASP136A, ASP136B, ASP388A, ASP388B, ASP396A, ASP396B, ASP425A, ASP425B, ASP557A, ASP557B, ASP558A, ASP558B, GLN133A, GLN133B, GLN392A, GLN392B, GLN426A, GLN426B, GLU129A, GLU129B, GLU140A, GLU140B, GLU384A, GLU384B, GLU386A, GLU386B, GLY134A, GLY134B, GLY141A, GLY141B, GLY387A, GLY387B, GLY424A, GLY424B, HIS391A, HIS391B, LEU125A, LEU125B, LEU131A, LEU131B, LYS427A, LYS427B, LYS608A, LYS608B, MET127A, MET127B, MET554A, MET554B, PHE385A, PHE385B, PRO132A, PRO132B, PRO552A, PRO552B, PRO556A, PRO556B, PRO559A, PRO559B, SER378A, SER378B, THR126A, THR126B, THR379A, THR379B, THR389A, THR389B, THR555A, THR555B, TYR375A, TYR375B, TYR421A, TYR421B, VAL121A, VAL121B, VAL130A, VAL130B
• A-C: ALA124A, ALA124C, ALA260A, ALA260C, ALA272A, ALA291A, ALA291C, ALA304A, ALA304C, ALA310A, ALA310C, ARG151A, ARG151C, ARG164A, ARG164C, ARG261A, ARG261C, ARG269A, ARG269C, ARG270A, ARG270C, ARG301A, ARG301C, ARG73A, ARG73C, ASN119A, ASN119C, ASN123A, ASN123C, ASN171A, ASN171C, ASN265A, ASN265C, ASN277A, ASN277C, ASP159A, ASP159C, ASP266A, ASP266C, ASP271A, ASP271C, ASP294A, ASP294C, ASP309A, ASP309C, ASP51A, ASP51C, ASP60A, ASP60C, ASP74A, ASP74C, GLN257A, GLN257C, GLN290A, GLN290C, GLN295A, GLN295C, GLN300A, GLN300C, GLN315A, GLN315C, GLN56A, GLN56C, GLN72A, GLN72C, GLU129A, GLU129C, GLY152A, GLY152C, GLY158A, GLY158C, GLY168A, GLY168C, GLY262A, GLY262C, GLY292A, GLY292C, GLY58A, GLY58C, HIS303A, HIS303C, HIS305A, HIS305C, HIS50A, HIS50C, ILE267A, ILE267C, ILE61A, ILE61C, LEU125A, LEU125C, LEU170A, LEU170C, LEU293A, LEU293C, LEU53A, LEU53C, LYS115A, LYS115C, LYS153A, LYS153C, MET162A, MET162C, MET258A, MET258C, MET302A, MET302C, PHE254A, PHE254C, PHE287C, PHE298A, PHE298C, PHE311A, PHE311C, PRO122A, PRO122C, PRO165A, PRO165C, PRO169A, PRO169C, PRO172A, PRO172C, PRO268A, PRO268C, PRO297A, PRO297C, PRO52A, PRO52C, PRO62A, PRO62C, SER54A, SER54C, SER59A, SER59C, THR126A, THR126C, THR163A, THR163C, THR173A, THR173C, THR259A, THR259C, THR289A, THR289C, THR57A, THR57C, TRP299A, TRP299C, TRP312A, TYR154A, TYR154C, TYR160A, TYR160C, TYR296A, TYR296C, TYR75A, TYR75C, VAL121A, VAL121C, VAL161A, VAL161C, VAL255A, VAL255C, VAL55A, VAL55C
• A-D: ALA272A, ALA272D, ALA475A, ALA475D, ALA486A, ALA486D, ALA488D, ALA504A, ALA504D, ALA553A, ALA553D, ARG269A, ARG269D, ARG270A, ARG270D, ARG483A, ARG483D, ARG502A, ARG502D, ARG507A, ARG507D, ARG611A, ARG611D, ASN277A, ASN277D, ASP271A, ASP271D, ASP273A, ASP273D, ASP274A, ASP274D, ASP468A, ASP468D, ASP473A, ASP473D, ASP500A, ASP500D, ASP509A, ASP509D, ASP558A, ASP558D, GLN489A, GLN489D, GLN501A, GLN501D, GLN551A, GLN551D, GLN615A, GLN615D, GLU503A, GLU503D, GLU505A, GLU505D, GLU514A, GLU514D, GLU516A, GLU516D, GLU565A, GLU565D, GLY562A, GLY562D, GLY563A, GLY563D, HIS455A, HIS455D, HIS476A, HIS476D, ILE267D, ILE481A, LEU279A, LEU279D, LYS280A, LYS280D, LYS560A, LYS560D, MET554A, MET554D, MET561A, MET561D, MET613A, MET613D, PHE485A, PHE485D, PHE621A, PHE621D, PRO268A, PRO268D, PRO474A, PRO474D, PRO477A, PRO477D, PRO479A, PRO479D, PRO484A, PRO484D, PRO508A, PRO508D, PRO552A, PRO552D, PRO556A, PRO556D, PRO559A, PRO559D, SER469A, SER469D, SER472A, SER472D, SER482A, SER482D, SER506A, SER506D, THR276A, THR276D, THR512A, THR512D, THR515A, THR555A, THR555D, THR647A, TYR275A, TYR275D, TYR470A, TYR470D, TYR564A, TYR564D, VAL471A, VAL471D, VAL478A, VAL478D, VAL510A, VAL510D, VAL511A, VAL511D, VAL517A, VAL517D, VAL550A, VAL550D, VAL645A, VAL645D
• B-C: ALA272B, ALA272C, ALA475B, ALA475C, ALA486B, ALA486C, ALA488B, ALA488C, ALA504B, ALA504C, ALA553B, ALA553C, ARG269B, ARG269C, ARG270B, ARG270C, ARG483B, ARG483C, ARG502B, ARG502C, ARG507B, ARG507C, ARG611B, ARG611C, ASN277B, ASN277C, ASP271B, ASP271C, ASP273B, ASP273C, ASP274B, ASP274C, ASP468B, ASP468C, ASP473B, ASP473C, ASP500B, ASP500C, ASP509B, ASP509C, ASP558B, ASP558C, GLN489B, GLN489C, GLN501B, GLN501C, GLN551B, GLN551C, GLN615B, GLN615C, GLU503B, GLU503C, GLU505B, GLU505C, GLU514B, GLU514C, GLU516B, GLU516C, GLU565B, GLU565C, GLY562B, GLY562C, GLY563B, GLY563C, HIS455B, HIS455C, HIS476B, HIS476C, ILE267B, LEU279B, LEU279C, LYS280B, LYS280C, LYS560B, LYS560C, MET554B, MET554C, MET561B, MET561C, MET613B, MET613C, PHE485B, PHE485C, PHE621B, PHE621C, PRO268B, PRO268C, PRO474B, PRO474C, PRO477B, PRO477C, PRO479B, PRO479C, PRO484B, PRO484C, PRO508B, PRO508C, PRO552B, PRO552C, PRO556B, PRO556C, PRO559B, PRO559C, SER469B, SER469C, SER472B, SER472C, SER482B, SER482C, SER506B, SER506C, THR276B, THR276C, THR512B, THR512C, THR515C, THR555B, THR555C, TYR275B, TYR275C, TYR470B, TYR470C, TYR564B, TYR564C, VAL471B, VAL471C, VAL478B, VAL478C, VAL510B, VAL510C, VAL511B, VAL511C, VAL517B, VAL517C, VAL550B, VAL550C, VAL645B, VAL645C
• B-D: ALA124B, ALA124D, ALA260B, ALA260D, ALA291B, ALA291D, ALA304B, ALA304D, ALA310B, ALA310D, ARG151B, ARG151D, ARG164B, ARG164D, ARG261B, ARG261D, ARG269B, ARG269D, ARG270B, ARG270D, ARG301B, ARG301D, ARG73B, ARG73D, ASN119B, ASN119D, ASN123B, ASN123D, ASN171B, ASN171D, ASN265B, ASN265D, ASN277B, ASN277D, ASP159B, ASP159D, ASP266B, ASP266D, ASP271B, ASP271D, ASP294B, ASP309B, ASP309D, ASP51B, ASP51D, ASP60B, ASP60D, ASP74B, ASP74D, GLN257B, GLN257D, GLN290B, GLN290D, GLN295B, GLN295D, GLN300B, GLN300D, GLN315B, GLN315D, GLN56B, GLN56D, GLN72B, GLN72D, GLU129B, GLU129D, GLY152B, GLY152D, GLY158B, GLY158D, GLY168B, GLY168D, GLY262B, GLY262D, GLY292B, GLY292D, GLY58B, GLY58D, HIS303B, HIS303D, HIS305B, HIS305D, HIS50B, HIS50D, ILE267B, ILE267D, ILE61B, ILE61D, LEU125B, LEU125D, LEU170B, LEU170D, LEU293B, LEU293D, LEU53B, LEU53D, LYS115B, LYS115D, LYS153B, LYS153D, LYS174D, MET127B, MET162B, MET162D, MET258B, MET258D, MET302B, MET302D, PHE254B, PHE254D, PHE287B, PHE287D, PHE298B, PHE298D, PHE311B, PHE311D, PRO122B, PRO122D, PRO165B, PRO165D, PRO169B, PRO169D, PRO172B, PRO172D, PRO268B, PRO268D, PRO297B, PRO297D, PRO52B, PRO52D, PRO62B, PRO62D, SER286D, SER54B, SER54D, SER59B, SER59D, THR126B, THR126D, THR163B, THR163D, THR173B, THR173D, THR259B, THR259D, THR289B, THR289D, THR57B, THR57D, TRP299B, TRP299D, TRP312B, TYR154B, TYR154D, TYR160B, TYR160D, TYR296B, TYR296D, TYR75B, TYR75D, VAL121B, VAL121D, VAL161B, VAL161D, VAL255B, VAL255D, VAL55B, VAL55D
• B-L: ARG324L, ARG73B, ARG78B, ASN102L, HIS190B, HIS190L, HIS219L, LYS358L, LYS89B, PRO62B
• C-D: ALA124C, ALA124D, ALA553C, ALA553D, ARG120C, ARG120D, ARG128C, ARG128D, ARG394C, ARG394D, ARG395C, ARG395D, ASN374C, ASN376C, ASN376D, ASP135C, ASP135D, ASP136C, ASP136D, ASP388C, ASP388D, ASP396C, ASP396D, ASP425C, ASP425D, ASP557C, ASP557D, ASP558C, ASP558D, GLN133C, GLN133D, GLN392C, GLN392D, GLN426C, GLN426D, GLU129C, GLU129D, GLU140C, GLU140D, GLU384C, GLU384D, GLU386C, GLU386D, GLY134C, GLY134D, GLY141C, GLY387C, GLY387D, GLY424C, GLY424D, HIS391C, HIS391D, LEU125C, LEU125D, LEU131C, LEU131D, LYS427C, LYS427D, LYS608C, LYS608D, MET127C, MET127D, MET554C, MET554D, PHE385C, PHE385D, PRO132C, PRO132D, PRO552C, PRO552D, PRO556C, PRO556D, PRO559C, PRO559D, SER378C, SER378D, THR126C, THR126D, THR379C, THR379D, THR389C, THR389D, THR555C, THR555D, TYR375C, TYR375D, VAL121C, VAL121D, VAL130C, VAL130D, VAL139C
• D-L: ARG101L, GLN295D, GLN300D, PRO193L
• E-F: ALA124E, ALA124F, ALA553E, ALA553F, ARG120E, ARG120F, ARG128E, ARG128F, ARG394E, ARG394F, ARG395E, ARG395F, ASN374F, ASN376E, ASN376F, ASP135E, ASP135F, ASP136E, ASP136F, ASP388E, ASP388F, ASP396E, ASP396F, ASP425E, ASP425F, ASP557E, ASP557F, ASP558E, ASP558F, GLN133E, GLN133F, GLN392E, GLN392F, GLN426E, GLN426F, GLU129E, GLU129F, GLU140E, GLU140F, GLU384E, GLU384F, GLU386E, GLU386F, GLY134E, GLY134F, GLY141F, GLY387E, GLY387F, GLY424E, GLY424F, HIS391E, HIS391F, LEU125E, LEU125F, LEU131E, LEU131F, LYS427E, LYS427F, LYS608E, LYS608F, MET127E, MET127F, MET554E, MET554F, PHE385E, PHE385F, PRO132E, PRO132F, PRO552E, PRO552F, PRO556E, PRO556F, PRO559E, PRO559F, SER378E, SER378F, THR126E, THR126F, THR379E, THR379F, THR389E, THR389F, THR555E, THR555F, TYR375E, TYR375F, TYR421E, TYR421F, VAL121E, VAL121F, VAL130E, VAL130F
• E-G: ALA124E, ALA124G, ALA260E, ALA260G, ALA272G, ALA291E, ALA291G, ALA304E, ALA304G, ALA310E, ALA310G, ARG151E, ARG151G, ARG164E, ARG164G, ARG261E, ARG261G, ARG269E, ARG269G, ARG270E, ARG270G, ARG301E, ARG301G, ARG73E, ARG73G, ASN119E, ASN119G, ASN123E, ASN123G, ASN171E, ASN171G, ASN265E, ASN265G, ASN277E, ASN277G, ASP159E, ASP159G, ASP266E, ASP266G, ASP271E, ASP271G, ASP294E, ASP294G, ASP309E, ASP309G, ASP51E, ASP51G, ASP60E, ASP60G, ASP74E, ASP74G, GLN257E, GLN257G, GLN290E, GLN290G, GLN295E, GLN295G, GLN300E, GLN300G, GLN315E, GLN315G, GLN56E, GLN56G, GLN72E, GLN72G, GLU129E, GLU129G, GLY152E, GLY152G, GLY158E, GLY158G, GLY168E, GLY168G, GLY262E, GLY262G, GLY292E, GLY292G, GLY58E, GLY58G, HIS303E, HIS303G, HIS305E, HIS305G, HIS50E, HIS50G, ILE267E, ILE267G, ILE61E, ILE61G, LEU125E, LEU125G, LEU170E, LEU170G, LEU293E, LEU293G, LEU53E, LEU53G, LYS115E, LYS115G, LYS153E, LYS153G, MET127G, MET162E, MET162G, MET258E, MET258G, MET302E, MET302G, PHE254E, PHE254G, PHE287E, PHE287G, PHE298E, PHE298G, PHE311E, PHE311G, PRO122E, PRO122G, PRO165E, PRO165G, PRO169E, PRO169G, PRO172E, PRO172G, PRO268E, PRO268G, PRO297E, PRO297G, PRO52E, PRO52G, PRO62E, PRO62G, SER286E, SER54E, SER54G, SER59E, SER59G, THR126E, THR126G, THR163E, THR163G, THR173E, THR173G, THR259E, THR259G, THR289E, THR289G, THR57E, THR57G, TRP299E, TRP299G, TRP312E, TYR154E, TYR154G, TYR160E, TYR160G, TYR296E, TYR296G, TYR75E, TYR75G, VAL121E, VAL121G, VAL161E, VAL161G, VAL255E, VAL255G, VAL55E, VAL55G
• E-H: ALA272E, ALA272H, ALA475E, ALA475H, ALA486E, ALA486H, ALA488E, ALA504E, ALA504H, ALA553E, ALA553H, ARG269E, ARG269H, ARG270E, ARG270H, ARG483E, ARG483H, ARG502E, ARG502H, ARG507E, ARG507H, ARG611E, ARG611H, ASN277E, ASN277H, ASP271E, ASP271H, ASP273E, ASP273H, ASP274E, ASP274H, ASP468E, ASP468H, ASP473E, ASP473H, ASP500E, ASP500H, ASP509E, ASP509H, ASP558E, ASP558H, GLN489E, GLN489H, GLN501E, GLN501H, GLN551E, GLN551H, GLN615E, GLN615H, GLU503E, GLU503H, GLU505E, GLU505H, GLU514E, GLU514H, GLU516E, GLU516H, GLU565E, GLU565H, GLY562E, GLY562H, GLY563E, GLY563H, HIS455E, HIS455H, HIS476E, HIS476H, ILE267E, LEU279E, LEU279H, LYS280E, LYS280H, LYS560E, LYS560H, MET554E, MET554H, MET561E, MET561H, MET613E, MET613H, PHE485E, PHE485H, PHE621E, PHE621H, PRO268E, PRO268H, PRO474E, PRO474H, PRO477E, PRO477H, PRO479E, PRO479H, PRO484E, PRO484H, PRO508E, PRO508H, PRO552E, PRO552H, PRO556E, PRO556H, PRO559E, PRO559H, SER469E, SER469H, SER472E, SER472H, SER482E, SER482H, SER506E, SER506H, SER619H, THR276E, THR276H, THR512E, THR512H, THR515H, THR555E, THR555H, TYR275E, TYR275H, TYR470E, TYR470H, TYR564E, TYR564H, VAL471E, VAL471H, VAL478E, VAL478H, VAL510E, VAL510H, VAL511E, VAL511H, VAL517E, VAL517H, VAL550E, VAL550H, VAL645E, VAL645H
• E-M: ARG101M, ASP294E, GLU194M
• F-G: ALA272F, ALA272G, ALA475F, ALA475G, ALA486F, ALA486G, ALA488F, ALA488G, ALA504F, ALA504G, ALA553F, ALA553G, ARG269F, ARG269G, ARG270F, ARG270G, ARG483F, ARG483G, ARG502F, ARG502G, ARG507F, ARG507G, ARG611F, ARG611G, ASN277F, ASN277G, ASP271F, ASP271G, ASP273F, ASP273G, ASP274F, ASP274G, ASP468F, ASP468G, ASP473F, ASP473G, ASP500F, ASP500G, ASP509F, ASP509G, ASP558F, GLN489F, GLN489G, GLN501F, GLN501G, GLN551F, GLN551G, GLN615F, GLN615G, GLU503F, GLU503G, GLU505F, GLU505G, GLU514F, GLU514G, GLU516F, GLU516G, GLU565F, GLU565G, GLY562F, GLY562G, GLY563F, GLY563G, HIS455F, HIS455G, HIS476F, HIS476G, ILE267G, ILE481F, LEU279F, LEU279G, LYS280F, LYS280G, LYS560F, LYS560G, MET554F, MET554G, MET561F, MET561G, MET613F, MET613G, PHE485F, PHE485G, PHE621F, PHE621G, PRO268F, PRO268G, PRO474F, PRO474G, PRO477F, PRO477G, PRO479F, PRO479G, PRO484F, PRO484G, PRO508F, PRO508G, PRO552F, PRO552G, PRO556F, PRO556G, PRO559F, PRO559G, SER469F, SER469G, SER472F, SER472G, SER482F, SER482G, SER506F, SER506G, THR276F, THR276G, THR512F, THR512G, THR555F, THR555G, TYR275F, TYR275G, TYR470F, TYR470G, TYR564F, TYR564G, VAL471F, VAL471G, VAL478F, VAL478G, VAL510F, VAL510G, VAL511F, VAL511G, VAL517F, VAL517G, VAL550F, VAL550G, VAL645F, VAL645G
• F-H: ALA124F, ALA124H, ALA260F, ALA260H, ALA291F, ALA291H, ALA304F, ALA304H, ALA310F, ALA310H, ARG151F, ARG151H, ARG164F, ARG164H, ARG261F, ARG261H, ARG269F, ARG269H, ARG270F, ARG270H, ARG301F, ARG301H, ARG73F, ARG73H, ASN119F, ASN119H, ASN123F, ASN123H, ASN171F, ASN171H, ASN265F, ASN265H, ASN277F, ASN277H, ASP159F, ASP159H, ASP266F, ASP266H, ASP271F, ASP271H, ASP294F, ASP294H, ASP309F, ASP309H, ASP51F, ASP51H, ASP60F, ASP60H, ASP74F, ASP74H, GLN257F, GLN257H, GLN290F, GLN290H, GLN295F, GLN295H, GLN300F, GLN300H, GLN315F, GLN315H, GLN56F, GLN56H, GLN72F, GLN72H, GLU129F, GLU129H, GLY152F, GLY152H, GLY158F, GLY158H, GLY168F, GLY168H, GLY262F, GLY262H, GLY292F, GLY292H, GLY58F, GLY58H, HIS303F, HIS303H, HIS305F, HIS305H, HIS50F, HIS50H, ILE267F, ILE267H, ILE61F, ILE61H, LEU125F, LEU125H, LEU170F, LEU170H, LEU293F, LEU293H, LEU53F, LEU53H, LYS115F, LYS115H, LYS153F, LYS153H, MET127F, MET162F, MET162H, MET258F, MET258H, MET302F, MET302H, PHE254F, PHE254H, PHE298F, PHE298H, PHE311F, PHE311H, PRO122F, PRO122H, PRO165F, PRO165H, PRO169F, PRO169H, PRO172F, PRO172H, PRO268F, PRO268H, PRO297F, PRO297H, PRO52F, PRO52H, PRO62F, PRO62H, SER54F, SER54H, SER59F, SER59H, THR126F, THR126H, THR163F, THR163H, THR173F, THR173H, THR259F, THR259H, THR289F, THR289H, THR57F, THR57H, TRP299F, TRP299H, TRP312F, TYR154F, TYR154H, TYR160F, TYR160H, TYR296F, TYR296H, TYR75F, TYR75H, VAL121F, VAL121H, VAL161F, VAL161H, VAL255F, VAL255H, VAL55F, VAL55H
• F-I: ALA641I, GLY168F, HIS167F, LYS639I, PRO169F, PRO172F, PRO640I
• F-K: ARG101K, ASN99K, GLN295F, ILE76K, LYS98K, THR259F
• F-L: ASP453L, ASP86F, LYS174F
• G-H: ALA124G, ALA124H, ALA553G, ALA553H, ALA607G, ARG120G, ARG120H, ARG128G, ARG128H, ARG394G, ARG394H, ARG395G, ARG395H, ASN376G, ASN376H, ASP135G, ASP135H, ASP136G, ASP136H, ASP388G, ASP388H, ASP396G, ASP396H, ASP425G, ASP425H, ASP557G, ASP557H, ASP558G, ASP558H, GLN133G, GLN133H, GLN392G, GLN392H, GLN426G, GLN426H, GLU129G, GLU129H, GLU140G, GLU140H, GLU384G, GLU384H, GLU386G, GLU386H, GLY134G, GLY134H, GLY141H, GLY387G, GLY387H, GLY424G, GLY424H, HIS391G, HIS391H, LEU125G, LEU125H, LEU131G, LEU131H, LYS427G, LYS427H, LYS608G, LYS608H, MET127G, MET127H, MET554G, MET554H, PHE385G, PHE385H, PRO132G, PRO132H, PRO552G, PRO552H, PRO556G, PRO556H, PRO559G, PRO559H, SER378G, SER378H, THR126G, THR126H, THR379G, THR379H, THR389G, THR389H, THR555G, THR555H, TYR375G, TYR375H, VAL121G, VAL121H, VAL130G, VAL130H, VAL139G, VAL517G
• G-M: ARG73G, HIS190G, HIS190M, LYS325M, LYS358M, LYS89G
• H-I: ALA281I, ALA291I, ALA638I, ASP294I, ASP51H, ASP637I, GLN290I, GLY282I, GLY285I, GLY292I, HIS50H, LEU53H, LYS280I, LYS639I, PHE287I, PHE636I, PRO52H, PRO640I, SER283I, SER286I, SER54H, THR289I, THR57H, VAL55H
• H-K: ALA100H, ALA221K, ALA411K, ARG101H, ARG101K, ARG198K, ARG73H, ARG78H, ASN102H, ASN102K, ASN123H, ASN191H, ASN191K, ASN196K, ASN99H, ASN99K, ASP183K, ASP186K, GLN72H, GLN72K, GLU194H, GLU194K, GLU404K, GLU79H, GLY197K, GLY409K, GLY87H, HIS190H, HIS190K, HIS219K, ILE76H, ILE94H, ILE96H, LEU188H, LEU188K, LEU222K, LEU406K, LEU90H, LYS115H, LYS223K, LYS407K, LYS77H, LYS89H, LYS98H, LYS98K, MET81H, MET84H, PRO193H, PRO193K, PRO220K, PRO408K, PRO52H, PRO62H, PRO83H, PRO97H, SER195H, SER195K, SER410K, SER412K, THR92H, TRP182K, TRP187H, TRP187K, TYR405K, TYR75H, TYR91H, VAL185K, VAL189K, VAL192H, VAL192K, VAL199K, VAL80H, VAL82H, VAL93H
• I-J: ALA124I, ALA124J, ALA553I, ALA553J, ARG120I, ARG120J, ARG128I, ARG128J, ARG394I, ARG394J, ARG395I, ARG395J, ASN374J, ASN376I, ASN376J, ASP135I, ASP135J, ASP136I, ASP136J, ASP388I, ASP388J, ASP396I, ASP396J, ASP425I, ASP425J, ASP557I, ASP557J, ASP558I, ASP558J, GLN133I, GLN133J, GLN392I, GLN392J, GLN426I, GLN426J, GLU129I, GLU129J, GLU140I, GLU140J, GLU384I, GLU384J, GLU386I, GLU386J, GLY134I, GLY134J, GLY141I, GLY141J, GLY387I, GLY387J, GLY424I, GLY424J, HIS391I, HIS391J, LEU125I, LEU125J, LEU131I, LEU131J, LYS427I, LYS427J, LYS608I, LYS608J, MET127I, MET127J, MET554I, MET554J, PHE385I, PHE385J, PRO132I, PRO132J, PRO552I, PRO552J, PRO556I, PRO556J, PRO559I, PRO559J, SER378I, SER378J, THR126I, THR126J, THR379I, THR379J, THR389I, THR389J, THR555I, THR555J, TYR375I, TYR375J, TYR421I, TYR421J, VAL121I, VAL121J, VAL130I, VAL130J, VAL139I, VAL139J
• I-K: ALA124I, ALA124K, ALA260I, ALA260K, ALA272K, ALA291I, ALA291K, ALA304I, ALA304K, ALA310I, ALA310K, ARG151I, ARG151K, ARG164I, ARG164K, ARG261I, ARG261K, ARG269I, ARG269K, ARG270I, ARG270K, ARG301I, ARG301K, ARG73I, ARG73K, ASN119I, ASN119K, ASN123I, ASN123K, ASN171I, ASN171K, ASN265I, ASN265K, ASN277I, ASN277K, ASP159I, ASP159K, ASP266I, ASP266K, ASP271I, ASP271K, ASP294I, ASP294K, ASP309I, ASP309K, ASP51I, ASP51K, ASP60I, ASP60K, ASP74I, ASP74K, GLN257I, GLN257K, GLN290I, GLN290K, GLN295I, GLN295K, GLN300I, GLN300K, GLN315I, GLN315K, GLN56I, GLN56K, GLN72I, GLN72K, GLU129I, GLU129K, GLY152I, GLY152K, GLY158I, GLY158K, GLY168I, GLY168K, GLY262I, GLY262K, GLY292I, GLY292K, GLY58I, GLY58K, HIS303I, HIS303K, HIS305I, HIS305K, HIS50I, HIS50K, ILE267I, ILE267K, ILE61I, ILE61K, LEU125I, LEU125K, LEU170I, LEU170K, LEU293I, LEU293K, LEU53I, LEU53K, LYS115I, LYS115K, LYS153I, LYS153K, MET127I, MET162I, MET162K, MET258I, MET258K, MET302I, MET302K, PHE254I, PHE254K, PHE287I, PHE287K, PHE298I, PHE298K, PHE311I, PHE311K, PRO122I, PRO122K, PRO165I, PRO165K, PRO169I, PRO169K, PRO172I, PRO172K, PRO268I, PRO268K, PRO297I, PRO297K, PRO52I, PRO52K, PRO62I, PRO62K, SER286K, SER54I, SER54K, SER59I, SER59K, THR126I, THR126K, THR163I, THR163K, THR173I, THR173K, THR259I, THR259K, THR289I, THR289K, THR57I, THR57K, TRP299I, TRP299K, TRP312I, TYR154I, TYR154K, TYR160I, TYR160K, TYR206I, TYR296I, TYR296K, TYR75I, TYR75K, VAL121I, VAL121K, VAL161I, VAL161K, VAL255I, VAL255K, VAL55I, VAL55K
• I-L: ALA272I, ALA272L, ALA553I, ALA553L, ARG483I, ARG483L, ARG502I, ARG502L, ARG507I, ARG507L, ASP273I, ASP273L, ASP473I, ASP500I, ASP500L, ASP509I, ASP509L, GLU503I, GLU503L, GLU505I, GLU505L, GLU565I, GLU565L, HIS476I, HIS476L, SER506I, SER506L
• J-K: ALA272J, ALA272K, ALA553J, ALA553K, ARG269K, ARG270K, ARG483J, ARG483K, ARG502J, ARG502K, ARG507J, ARG507K, ARG611J, ASN277K, ASP271K, ASP273J, ASP273K, ASP274K, ASP473J, ASP500J, ASP500K, ASP509J, ASP509K, ASP558J, GLN551J, GLU503J, GLU503K, GLU505J, GLU505K, GLU514J, GLU516J, GLU565J, GLU565K, GLY562J, GLY563J, HIS476J, HIS476K, ILE267K, LEU279K, LYS280K, LYS560J, MET554J, MET561J, MET613J, PRO268K, PRO508J, PRO552J, PRO556J, PRO559J, SER506J, SER506K, THR276K, THR555J, TYR275K, TYR564J, VAL517J, VAL550J
• J-L: ARG301J, ARG301L, ASP159J, ASP159L, ASP60J, ASP60L, HIS305J, HIS305L, LEU53J, LEU53L, MET162J, MET162L, SER54L, SER59J, TYR160J, TYR160L
• K-L: ARG120K, ARG120L, ARG128K, ARG128L, ASP136K, ASP136L, ASP388K, ASP388L, ASP557K, ASP557L, GLU129L, GLU140K, GLU140L, GLU384K, GLU384L, GLU386K, GLU386L, HIS391K, HIS391L, LYS608K, LYS608L
• M-N: ARG120M, ARG120N, ARG128M, ARG128N, ASP136M, ASP136N, ASP388M, ASP388N, ASP557M, ASP557N, GLU129M, GLU129N, GLU140M, GLU140N, GLU384M, GLU384N, GLU386M, GLU386N, HIS391M, HIS391N, LYS608M, LYS608N
• M-O: ARG301M, ARG301O, ASP159M, ASP159O, ASP60M, ASP60O, HIS305M, HIS305O, LEU53M, LEU53O, MET162M, MET162O, TYR160M, TYR160O
• M-P: ALA272M, ALA553P, ARG483M, ARG483P, ARG502M, ARG502P, ARG507M, ARG507P, ASP273M, ASP273P, ASP473P, ASP500M, ASP500P, ASP509M, ASP509P, GLU503M, GLU503P, GLU505M, GLU505P, GLU565M, GLU565P, HIS476M, HIS476P, SER506M, SER506P
• N-O: ALA272N, ALA272O, ALA553N, ALA553O, ARG483N, ARG483O, ARG502N, ARG502O, ARG507N, ARG507O, ASP273N, ASP273O, ASP500N, ASP500O, ASP509N, ASP509O, GLU503N, GLU503O, GLU505N, GLU505O, GLU565N, GLU565O, HIS476N, HIS476O, SER506N, SER506O
• N-P: ARG301N, ARG301P, ASP159N, ASP159P, ASP60N, ASP60P, HIS305N, HIS305P, LEU53N, LEU53P, MET162P, SER54P, TYR160N, TYR160P
• O-P: ARG120O, ARG120P, ARG128O, ARG128P, ASP136O, ASP136P, ASP388O, ASP388P, ASP557O, ASP557P, GLU129O, GLU140O, GLU140P, GLU384O, GLU384P, GLU386O, GLU386P, HIS391O, HIS391P, LYS608O, LYS608P