2B0U

the structure of the follistatin:activin complex

• Total interactions analyzed: 6
• Total true interactions: 6
• Strongest Interaction:
  • Chains: C-D
  • Int. Res.: 78
  • Norm. En. per Res.: -3.7721
• Hub Node: A(3)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-30.1902	-14.4098	475.374	430.7741	139	31	11	16172	0	26	23
A-C	0.0	-2.2167	-59.1494	-61.3661	31	3	1	2525	0	4	2
A-D	-61.4531	-64.4584	-243.224	-369.1355	155	30	9	13343	1	44	32
B-C	-57.4022	-51.4734	-275.903	-384.7786	153	40	10	12755	4	43	30
B-D	-7.4301	-2.5317	-69.6312	-79.5929	31	1	1	2921	0	5	4
C-D	-69.7319	-94.1367	-130.356	-294.2246	78	18	0	5360	4	41	15

Interface residues

• A-B: ALA37A, ALA37B, ALA75A, ALA75B, ARG67A, ARG67B, ARG69A, ARG69B, ARG87A, ASN107A, ASN107B, ASN38A, ASN38B, ASN64A, ASN64B, ASN76A, ASN76B, ASP22A, ASP22B, CYS113A, CYS113B, CYS115A, CYS115B, CYS40A, CYS40B, CYS44B, CYS80A, CYS80B, CYS81A, CYS81B, GLN106A, GLN106B, GLN15A, GLN15B, GLU112A, GLU112B, GLU41A, GLU41B, GLY114A, GLY114B, GLY24A, GLY24B, GLY34B, GLY42A, GLY42B, GLY53A, GLY53B, HIS36A, HIS36B, HIS59A, HIS59B, HIS65A, HIS65B, HIS71A, HIS71B, ILE105A, ILE105B, ILE109A, ILE109B, ILE23A, ILE23B, ILE29A, ILE29B, ILE63A, ILE63B, LEU56A, LEU56B, LEU77A, LEU77B, LEU86A, LEU86B, LYS13A, LYS14A, LYS14B, LYS21A, LYS21B, LYS78A, LYS78B, LYS85A, LYS85B, MET108A, MET108B, MET68A, MET89A, MET89B, MET91A, MET91B, PHE16A, PHE16B, PHE17A, PHE17B, PHE20A, PHE20B, PHE58A, PHE58B, PHE74A, PHE74B, PRO73A, PRO73B, PRO83A, PRO83B, PRO88A, SER116A, SER116B, SER19A, SER19B, SER54A, SER54B, SER55A, SER55B, SER57A, SER57B, SER60A, SER60B, SER72B, SER79A, SER79B, THR61A, THR61B, THR84A, THR84B, TRP25A, TRP25B, TRP28A, TRP28B, TYR35A, TYR35B, TYR39A, TYR39B, TYR66A, TYR66B, VAL110A, VAL110B, VAL18A, VAL18B, VAL62A, VAL62B, VAL82A, VAL82B
• A-C: ASN44C, ASN53C, ASP104A, ASP27A, ASP95A, ASP96A, GLN106A, GLN98A, GLY24A, GLY54C, GLY97A, ILE101A, ILE105A, ILE23A, ILE29A, ILE51C, LYS103A, LYS48C, MET108A, MET50C, MET91A, PHE20A, PHE47C, PHE52C, PRO57C, THR45C, TRP25A, TRP28A, TRP49C, TYR93A, TYR94A
• A-D: ALA158D, ALA188D, ALA194D, ALA205D, ALA31A, ALA37A, ALA49A, ALA56D, ARG120D, ARG192D, ARG200D, ARG237D, ARG31D, ARG69A, ARG6D, ARG87A, ASN156D, ASN157D, ASN164D, ASN180D, ASN26A, ASN2D, ASN38A, ASN42D, ASN44D, ASN99A, ASN9A, ASP104A, ASP106D, ASP153D, ASP27A, ASP43D, ASP5A, ASP70D, ASP95A, ASP96A, CYS11A, CYS12A, CYS13D, CYS150D, CYS160D, CYS163D, CYS189D, CYS196D, CYS238D, CYS3D, CYS4A, CYS71D, GLN124D, GLN130D, GLN14D, GLN154D, GLN15A, GLN98A, GLU111A, GLU112A, GLU123D, GLU126D, GLU128D, GLU207D, GLU3A, GLY107D, GLY179D, GLY199D, GLY1A, GLY203D, GLY24A, GLY34A, GLY50A, GLY53A, GLY55D, GLY97A, HIS36A, HIS47A, HIS59A, HIS65A, ILE100A, ILE101A, ILE109A, ILE10A, ILE202D, ILE29A, ILE30A, ILE48A, ILE51D, LEU105D, LEU127D, LEU16D, LEU177D, LEU191D, LEU197D, LEU198D, LEU204D, LEU240D, LEU2A, LEU46D, LEU5D, LEU92A, LYS102A, LYS103A, LYS108D, LYS122D, LYS18D, LYS193D, LYS225D, LYS48D, LYS7A, MET108A, MET50D, MET89A, MET91A, PHE16A, PHE17A, PHE20A, PHE47D, PHE58A, PRO125D, PRO32A, PRO45A, SER187D, SER201D, SER239D, SER33A, SER33D, SER46A, SER52A, SER54A, SER57A, SER60A, SER90A, THR155D, THR162D, THR195D, THR19D, THR29D, THR34D, THR45D, THR51A, THR61A, TRP25A, TRP28A, TRP49D, TRP4D, TYR159D, TYR17D, TYR35A, TYR93A, TYR94A, VAL151D, VAL152D, VAL15D, VAL161D, VAL18A, VAL62A, VAL8A
• B-C: ALA158C, ALA188C, ALA194C, ALA205C, ALA31B, ALA37B, ALA49B, ALA56C, ALA8C, ARG120C, ARG192C, ARG200C, ARG237C, ARG31C, ARG69B, ARG6C, ARG87B, ASN156C, ASN157C, ASN164C, ASN180C, ASN26B, ASN2C, ASN38B, ASN42C, ASN44C, ASN99B, ASN9B, ASP104B, ASP106C, ASP153C, ASP27B, ASP43C, ASP5B, ASP95B, ASP96B, CYS11B, CYS12B, CYS13C, CYS150C, CYS160C, CYS163C, CYS167C, CYS189C, CYS196C, CYS238C, CYS3C, CYS4B, GLN124C, GLN130C, GLN14C, GLN154C, GLN15B, GLN98B, GLU111B, GLU123C, GLU126C, GLU128C, GLU207C, GLU3B, GLY107C, GLY179C, GLY199C, GLY1B, GLY203C, GLY34B, GLY50B, GLY53B, GLY55C, GLY6B, GLY97B, HIS190C, HIS36B, HIS47B, HIS59B, HIS65B, ILE100B, ILE101B, ILE109B, ILE10B, ILE202C, ILE29B, ILE30B, ILE48B, ILE51C, LEU105C, LEU127C, LEU16C, LEU177C, LEU191C, LEU197C, LEU198C, LEU204C, LEU240C, LEU2B, LEU46C, LEU56B, LEU5C, LEU92B, LYS102B, LYS103B, LYS122C, LYS18C, LYS193C, LYS225C, LYS48C, LYS75C, LYS7B, MET108B, MET50C, MET89B, MET91B, PHE16B, PHE17B, PHE47C, PHE58B, PRO125C, PRO32B, PRO45B, PRO88B, SER187C, SER201C, SER33B, SER46B, SER52B, SER54B, SER57B, SER60B, SER90B, THR155C, THR162C, THR195C, THR19C, THR29C, THR51B, THR61B, TRP25B, TRP28B, TRP49C, TRP4C, TYR159C, TYR17C, TYR185C, TYR35B, TYR93B, TYR94B, VAL151C, VAL152C, VAL15C, VAL161C, VAL18B, VAL62B, VAL8B
• B-D: ASN44D, ASN53D, ASP104B, ASP27B, ASP95B, ASP96B, GLN106B, GLN98B, GLY24B, GLY54D, GLY97B, ILE101B, ILE105B, ILE23B, ILE29B, ILE51D, LYS103B, LYS48D, MET108B, MET50D, MET91B, PHE20B, PHE47D, PHE52D, PRO57D, THR45D, TRP25B, TRP28B, TRP49D, TYR93B, TYR94B
• C-D: ALA188D, ALA56C, ALA56D, ALA8C, ALA8D, ARG12C, ARG12D, ARG192C, ARG192D, ASN10C, ASN10D, ASN53C, ASN53D, ASN58C, ASN58D, ASN80C, ASP242C, ASP242D, ASP247C, ASP247D, CYS13C, CYS13D, CYS241C, CYS241D, CYS245C, CYS245D, CYS266C, CYS266D, CYS59C, CYS59D, GLN7C, GLN7D, GLU243C, GLU243D, GLU38C, GLU38D, GLU39C, GLU39D, GLY11C, GLY11D, GLY223C, GLY223D, GLY224C, GLY224D, GLY54C, GLY54D, GLY55D, ILE60C, ILE60D, LEU240C, LEU240D, LEU244C, LEU244D, LYS225C, LYS225D, LYS226D, LYS48C, LYS48D, LYS81C, LYS82C, LYS82D, LYS84C, LYS84D, LYS9C, LYS9D, PHE52C, PHE52D, PRO246C, PRO246D, PRO57C, PRO57D, PRO61C, SER239C, SER248C, THR222C, THR222D, TRP49C, TRP49D