2AFK

crystal structure of mgamppcp-bound av2-av1 complex

• Total interactions analyzed: 28
• Total true interactions: 15
• Strongest Interaction:
  • Chains: B-D
  • Int. Res.: 272
  • Norm. En. per Res.: -4.2099
• Hub Node: A(4)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-221.1407	-45.1983	-1304.67	-1571.009	412	62	37	52700	14	118	103
A-D	-39.8815	-63.9395	-324.394	-428.215	135	14	7	12835	4	39	39
A-E	-16.0161	-62.8177	-88.1554	-166.9892	73	6	0	4441	2	38	23
A-F	-12.3583	-18.2388	-115.538	-146.1351	51	9	2	4836	1	9	12
B-C	-32.2909	-61.0905	-314.837	-408.2185	135	15	7	12681	4	37	37
B-D	-218.0527	-118.7128	-808.329	-1145.0945	272	52	7	32267	22	184	174
B-E	-20.9044	-12.0823	-110.949	-143.9357	55	12	1	4948	1	4	13
B-F	-12.4672	-48.1819	-125.462	-186.1111	87	5	1	5722	2	43	22
C-D	-228.4871	-43.1084	-1313.64	-1585.2355	411	71	38	52773	14	118	103
C-G	-13.1319	-60.3758	-103.814	-177.3217	75	2	0	5024	2	38	23
C-H	-5.1368	-9.556	-118.523	-133.2158	51	4	1	4980	1	10	13
D-G	-19.3972	-12.4945	-107.658	-139.5497	54	8	1	4587	1	4	12
D-H	-11.5319	-59.9236	-131.464	-202.9195	89	7	1	5908	3	43	22
E-F	-35.6233	20.5745	-278.475	-293.5237	157	32	4	12992	11	52	33
G-H	-60.0234	-17.91	-300.357	-378.2905	157	31	7	13581	9	48	31

Interface residues

• A-B: ALA108A, ALA10B, ALA122B, ALA123B, ALA132A, ALA140B, ALA155B, ALA217A, ALA235A, ALA24A, ALA251A, ALA25B, ALA265B, ALA337A, ALA340A, ALA457A, ALA460A, ALA477A, ALA61B, ALA63A, ALA65A, ALA67B, ALA69B, ALA94A, ALA97B, ARG100B, ARG105B, ARG108B, ARG187A, ARG210A, ARG239A, ARG248A, ARG25A, ARG270B, ARG28A, ARG28B, ARG345A, ARG431B, ARG453B, ARG461A, ARG481B, ARG59B, ARG60A, ARG93A, ARG96A, ARG97A, ASN104B, ASN107A, ASN113A, ASN130B, ASN137B, ASN145A, ASN230A, ASN397B, ASN445B, ASN56B, ASN65B, ASP116B, ASP117A, ASP121B, ASP122A, ASP133B, ASP136A, ASP17B, ASP19B, ASP222A, ASP22B, ASP234A, ASP256A, ASP262B, ASP266B, ASP27A, ASP38B, ASP403A, ASP41B, ASP426B, ASP445A, ASP454A, ASP454B, ASP462A, ASP6B, ASP77A, CYS113B, CYS138B, CYS153B, CYS154A, CYS249A, CYS471A, CYS62A, CYS70B, CYS88A, CYS95B, GLN119A, GLN129B, GLN136B, GLN18B, GLN191A, GLN252A, GLN268B, GLN37B, GLN3B, GLN432A, GLN45B, GLN476A, GLN4B, GLN53A, GLN53B, GLN58B, GLN71B, GLN90A, GLN93B, GLU109B, GLU120A, GLU120B, GLU137A, GLU139A, GLU153A, GLU156B, GLU184A, GLU18A, GLU22A, GLU243A, GLU244A, GLU259B, GLU261A, GLU263A, GLU32B, GLU334A, GLU336A, GLU33B, GLU380A, GLU408A, GLU410A, GLU411A, GLU427A, GLU42B, GLU440A, GLU480A, GLU51B, GLU54B, GLU60B, GLY102A, GLY105A, GLY127A, GLY134B, GLY147A, GLY157A, GLY159B, GLY160A, GLY185A, GLY188A, GLY191B, GLY232A, GLY233A, GLY255A, GLY257A, GLY267B, GLY30B, GLY406A, GLY424A, GLY424B, GLY435A, GLY448A, GLY448B, GLY452A, GLY455A, GLY55A, GLY61A, GLY66A, GLY69A, GLY74B, GLY84A, GLY87A, GLY89A, GLY91B, GLY94B, GLY95A, HIS106B, HIS193B, HIS396B, HIS429B, HIS442A, HIS451A, HIS457B, HIS477B, HIS478B, HIS480B, HIS80A, HIS83A, HIS90B, ILE101A, ILE123A, ILE135A, ILE147B, ILE148A, ILE156A, ILE158B, ILE159A, ILE197A, ILE225A, ILE231A, ILE240A, ILE259A, ILE262A, ILE40B, ILE425A, ILE430A, ILE436A, ILE451B, ILE458A, ILE59A, ILE79A, ILE81A, ILE8B, LEU131A, LEU134A, LEU135B, LEU141A, LEU144A, LEU14B, LEU158A, LEU16B, LEU17A, LEU193A, LEU241A, LEU242A, LEU24B, LEU261B, LEU264A, LEU427B, LEU475A, LEU55B, LEU56A, LEU62B, LEU73B, LYS121A, LYS129A, LYS130A, LYS132B, LYS133A, LYS139B, LYS143B, LYS146A, LYS176A, LYS21B, LYS23A, LYS26B, LYS27B, LYS330A, LYS341A, LYS34B, LYS39B, LYS414A, LYS426A, LYS428A, LYS433A, LYS449B, LYS474A, LYS50A, LYS51A, LYS68A, LYS68B, LYS76A, LYS7B, LYS9B, MET112A, MET118B, MET131B, MET154B, MET23B, MET271B, MET434A, MET465A, MET57A, MET86B, PHE103B, PHE107B, PHE109A, PHE114A, PHE118A, PHE142A, PHE15B, PHE174B, PHE186A, PHE189B, PHE216A, PHE230B, PHE269B, PHE31B, PHE381A, PHE409A, PHE429A, PHE431A, PHE44B, PHE450B, PHE453A, PHE456A, PHE459A, PHE471B, PHE474B, PHE57B, PHE99B, PRO110B, PRO13B, PRO143A, PRO144B, PRO155A, PRO187B, PRO21A, PRO264B, PRO333A, PRO36B, PRO449A, PRO472B, PRO54A, PRO66B, PRO72B, PRO85A, PRO87B, SER101B, SER112B, SER115B, SER116A, SER117B, SER11B, SER188B, SER190A, SER192B, SER218A, SER237A, SER238A, SER254A, SER258A, SER260A, SER2B, SER432B, SER443A, SER446B, SER447A, SER52A, SER67A, SER82A, SER92A, SER92B, THR103A, THR104A, THR111A, THR115A, THR119B, THR140A, THR141B, THR152B, THR215A, THR219A, THR263B, THR405A, THR47B, THR48B, THR58A, THR63B, TRP236A, TRP335A, TRP370B, TRP428B, TRP444A, TRP46B, TRP472A, TYR100A, TYR102B, TYR12B, TYR142B, TYR20A, TYR20B, TYR272B, TYR331A, TYR342A, TYR35B, TYR407A, TYR446A, TYR447B, TYR450A, TYR52B, TYR64A, TYR88B, TYR91A, TYR98B, TYR99A, VAL106A, VAL111B, VAL114B, VAL124A, VAL124B, VAL138A, VAL157B, VAL16A, VAL189A, VAL190B, VAL19A, VAL223A, VAL250A, VAL260B, VAL268A, VAL338A, VAL339A, VAL404A, VAL43B, VAL5B, VAL64B, VAL70A, VAL86A, VAL89B, VAL96B
• A-D: ALA108A, ALA342D, ALA477A, ALA514D, ALA94A, ARG345A, ARG348D, ARG350D, ARG439A, ARG461A, ARG523D, ARG93A, ARG96A, ARG97A, ASN107A, ASN230A, ASN468A, ASN469A, ASN518D, ASN98A, ASP256A, ASP323D, ASP326D, ASP353D, ASP357D, ASP445A, ASP462A, ASP464A, ASP516D, ASP520D, CYS388D, CYS471A, GLN432A, GLN476A, GLN513D, GLN90A, GLU327D, GLU347D, GLU385D, GLU440A, GLU480A, GLY102A, GLY105A, GLY232A, GLY233A, GLY349D, GLY364D, GLY387D, GLY435A, GLY448A, GLY511D, GLY95A, HIS359D, HIS363D, HIS519D, ILE101A, ILE340D, ILE425A, ILE436A, LEU322D, LEU329D, LEU344D, LEU351D, LEU362D, LEU383D, LEU384D, LEU386D, LEU420A, LEU467A, LEU475A, LEU502D, LEU505D, LEU521D, LYS331D, LYS341A, LYS346D, LYS365D, LYS381D, LYS417D, LYS428A, LYS433A, LYS473A, LYS474A, LYS76A, MET330D, MET354D, MET355D, MET434A, MET463A, MET465A, MET512D, PHE328D, PHE429A, PHE431A, PHE438A, PRO339D, PRO341D, PRO414D, PRO437A, PRO449A, PRO470A, PRO478A, SER333D, SER343D, SER358D, SER413D, SER443A, SER447A, SER92A, THR103A, THR104A, THR111A, THR325D, THR345D, THR356D, THR360D, THR466A, THR509D, THR515D, TRP236A, TRP361D, TRP444A, TRP472A, TRP479A, TYR100A, TYR342A, TYR415D, TYR446A, TYR487D, TYR517D, TYR91A, TYR99A, VAL106A, VAL352D, VAL522D
• A-E: ALA136E, ALA61E, ALA62E, ALA64E, ALA98E, ARG100E, ARG140E, ARG182A, ARG187A, ARG60A, ASN107E, ASN142E, ASN49A, ASP128A, ASP161A, ASP162A, ASP200A, ASP69E, CYS132E, CYS154A, CYS97E, GLU111E, GLU141E, GLU153A, GLU164A, GLU184A, GLU63E, GLU68E, GLY101E, GLY126A, GLY133E, GLY134E, GLY157A, GLY160A, GLY175E, GLY188A, GLY65E, GLY96E, GLY99E, HIS196A, HIS383A, ILE103E, ILE123A, ILE156A, ILE159A, ILE163A, ILE197A, LEU158A, LEU193A, LYS129A, LYS168A, LYS170E, LYS50A, LYS51A, MET137E, MET58E, PHE108E, PHE135E, PHE186A, PRO155A, SER152A, SER165A, SER174E, SER190A, SER192A, THR104E, THR66E, TYR171E, VAL124A, VAL131E, VAL169A, VAL189A, VAL67E
• A-F: ALA105F, ALA61F, ALA62F, ALA64F, ALA98F, ARG100F, ASN107F, ASP122A, ASP128A, ASP161A, ASP162A, CYS97F, GLN119A, GLU120A, GLU59F, GLU63F, GLU68F, GLU92F, GLY101F, GLY126A, GLY127A, GLY160A, GLY65F, GLY89F, GLY90F, GLY94F, GLY96F, GLY99F, ILE103F, ILE123A, ILE159A, ILE57F, LEU158A, LYS121A, LYS129A, MET58F, MET60F, PHE108F, PHE118A, PHE125A, PRO155A, PRO40F, PRO91F, SER88F, THR104F, THR56F, THR66F, VAL102F, VAL124A, VAL67F, VAL95F
• B-C: ALA108C, ALA342B, ALA477C, ALA514B, ALA94C, ARG345C, ARG348B, ARG350B, ARG439C, ARG461C, ARG523B, ARG93C, ARG96C, ARG97C, ASN107C, ASN230C, ASN468C, ASN469C, ASN518B, ASN98C, ASP256C, ASP323B, ASP326B, ASP353B, ASP357B, ASP445C, ASP462C, ASP464C, ASP516B, ASP520B, CYS388B, CYS471C, GLN432C, GLN476C, GLN513B, GLN90C, GLU327B, GLU347B, GLU385B, GLU440C, GLU480C, GLY102C, GLY105C, GLY232C, GLY233C, GLY349B, GLY364B, GLY387B, GLY435C, GLY448C, GLY511B, GLY95C, HIS359B, HIS363B, HIS519B, ILE101C, ILE340B, ILE425C, ILE436C, LEU322B, LEU329B, LEU344B, LEU351B, LEU362B, LEU383B, LEU384B, LEU386B, LEU420C, LEU467C, LEU475C, LEU502B, LEU505B, LEU521B, LYS331B, LYS341C, LYS346B, LYS365B, LYS381B, LYS417B, LYS428C, LYS433C, LYS473C, LYS474C, LYS76C, MET330B, MET354B, MET355B, MET434C, MET463C, MET465C, MET512B, PHE328B, PHE429C, PHE431C, PHE438C, PRO339B, PRO341B, PRO414B, PRO437C, PRO449C, PRO470C, PRO478C, SER333B, SER343B, SER358B, SER413B, SER443C, SER447C, SER92C, THR103C, THR104C, THR111C, THR325B, THR345B, THR356B, THR360B, THR466C, THR509B, THR515B, TRP236C, TRP361B, TRP444C, TRP472C, TRP479C, TYR100C, TYR342C, TYR415B, TYR446C, TYR487B, TYR517B, TYR91C, TYR99C, VAL106C, VAL352B, VAL522B
• B-D: ALA10B, ALA10D, ALA265B, ALA265D, ALA273B, ALA273D, ALA342B, ALA342D, ALA514B, ALA514D, ARG105B, ARG105D, ARG108B, ARG108D, ARG238B, ARG238D, ARG270B, ARG270D, ARG28B, ARG28D, ARG348B, ARG348D, ARG350B, ARG350D, ARG366B, ARG366D, ARG431B, ARG431D, ARG453B, ARG453D, ARG468B, ARG468D, ARG476B, ARG476D, ARG481B, ARG481D, ARG504B, ARG504D, ARG510B, ARG510D, ARG523B, ARG523D, ASN445B, ASN445D, ASN499B, ASN499D, ASN518B, ASN518D, ASP17B, ASP17D, ASP262B, ASP262D, ASP266B, ASP266D, ASP353B, ASP353D, ASP357B, ASP357D, ASP41B, ASP41D, ASP440B, ASP440D, ASP454B, ASP454D, ASP475B, ASP475D, ASP506B, ASP506D, ASP516B, ASP516D, ASP520B, ASP520D, GLN37B, GLN37D, GLN452B, GLN452D, GLN492B, GLN492D, GLN513B, GLN513D, GLU109B, GLU109D, GLU258B, GLU258D, GLU259B, GLU259D, GLU347B, GLU347D, GLU461B, GLU461D, GLU463B, GLU463D, GLU488B, GLU488D, GLU503B, GLU503D, GLU507B, GLU507D, GLU508B, GLU508D, GLY267B, GLY267D, GLY274B, GLY274D, GLY349B, GLY349D, GLY364B, GLY364D, GLY448B, GLY448D, GLY511B, GLY511D, HIS106B, HIS106D, HIS359B, HIS359D, HIS457B, HIS457D, HIS477B, HIS477D, HIS478B, HIS478D, HIS480B, HIS480D, HIS519B, HIS519D, ILE40B, ILE40D, ILE451B, ILE451D, ILE473B, ILE473D, ILE501B, ILE501D, LEU14B, LEU14D, LEU16B, LEU16D, LEU234B, LEU234D, LEU24B, LEU24D, LEU261B, LEU261D, LEU351B, LEU351D, LEU362B, LEU362D, LEU456B, LEU456D, LEU466B, LEU466D, LEU479B, LEU479D, LEU494B, LEU494D, LEU497B, LEU497D, LEU502B, LEU502D, LEU505B, LEU505D, LEU521B, LEU521D, LYS21B, LYS21D, LYS346B, LYS346D, LYS34B, LYS34D, LYS365B, LYS365D, LYS438B, LYS438D, LYS449B, LYS449D, LYS458B, LYS458D, LYS460B, LYS460D, LYS7B, LYS7D, MET354B, MET354D, MET355B, MET355D, MET491B, MET491D, MET512B, MET512D, PHE107B, PHE107D, PHE15B, PHE15D, PHE435B, PHE435D, PHE44B, PHE44D, PHE450B, PHE450D, PHE474B, PHE474D, PRO110B, PRO110D, PRO13B, PRO13D, PRO257B, PRO257D, PRO264B, PRO264D, PRO465B, PRO465D, PRO472B, PRO472D, SER101B, SER101D, SER11B, SER11D, SER358B, SER358D, SER446B, SER446D, SER482B, SER482D, SER500B, SER500D, THR263B, THR263D, THR345B, THR345D, THR356B, THR356D, THR360B, THR360D, THR455B, THR455D, THR47B, THR47D, THR495B, THR495D, THR496B, THR496D, THR509B, THR509D, THR515B, THR515D, TRP361B, TRP361D, TRP428B, TRP428D, TYR102B, TYR102D, TYR12B, TYR12D, TYR20B, TYR20D, TYR35B, TYR35D, TYR447B, TYR447D, TYR517B, TYR517D, VAL260B, VAL260D, VAL352B, VAL352D, VAL464B, VAL464D, VAL498B, VAL498D, VAL522B, VAL522D
• B-E: ALA105E, ALA122B, ALA123B, ALA164B, ALA61E, ALA62E, ALA64E, ALA98E, ARG100E, ASN107E, ASP121B, ASP160B, ASP161B, CYS97E, GLN128B, GLN129B, GLU120B, GLU59E, GLU63E, GLU68E, GLU92E, GLY101E, GLY126B, GLY127B, GLY159B, GLY65E, GLY89E, GLY90E, GLY94E, GLY96E, GLY99E, HIS90B, ILE103E, ILE158B, ILE57E, LEU70E, MET118B, MET154B, MET58E, MET60E, PHE108E, PHE125B, PHE165B, PRO40E, PRO91E, SER88E, THR104E, THR119B, THR56E, THR66E, VAL102E, VAL124B, VAL157B, VAL67E, VAL95E
• B-F: ALA123B, ALA136F, ALA155B, ALA164B, ALA172F, ALA64F, ALA98F, ARG100F, ARG140F, ARG206B, ARG401B, ASN107F, ASN142F, ASN163B, ASN167B, ASN168B, ASN173F, ASN199B, ASN399B, ASP160B, ASP161B, ASP69F, CYS132F, CYS153B, CYS97F, GLN128B, GLN129B, GLN71B, GLU110F, GLU111F, GLU112F, GLU141F, GLU156B, GLU172B, GLU299B, GLU63F, GLU68F, GLY101F, GLY113F, GLY126B, GLY133F, GLY134F, GLY159B, GLY175F, GLY191B, GLY65F, GLY96F, GLY99F, HIS185B, ILE103F, ILE139F, ILE158B, ILE166B, LEU162B, LEU210B, LYS132B, LYS170B, LYS170F, LYS171B, LYS211B, LYS300B, LYS303B, LYS400B, MET137F, PHE125B, PHE135F, PHE165B, PHE183B, PHE189B, PRO187B, SER169B, SER174F, SER176F, SER188B, THR104F, THR151B, THR152B, THR186B, THR195B, THR66F, TYR171F, VAL124B, VAL131F, VAL157B, VAL169F, VAL190B, VAL67F
• C-D: ALA108C, ALA10D, ALA122D, ALA123D, ALA132C, ALA140D, ALA155D, ALA217C, ALA235C, ALA24C, ALA251C, ALA25D, ALA265D, ALA337C, ALA340C, ALA457C, ALA460C, ALA477C, ALA61D, ALA63C, ALA65C, ALA67D, ALA69D, ALA94C, ALA97D, ARG100D, ARG105D, ARG108D, ARG187C, ARG210C, ARG239C, ARG248C, ARG25C, ARG270D, ARG28C, ARG28D, ARG345C, ARG431D, ARG453D, ARG461C, ARG481D, ARG59D, ARG60C, ARG93C, ARG96C, ARG97C, ASN104D, ASN107C, ASN113C, ASN130D, ASN137D, ASN145C, ASN230C, ASN397D, ASN445D, ASN56D, ASN65D, ASP116D, ASP117C, ASP121D, ASP122C, ASP133D, ASP136C, ASP17D, ASP19D, ASP222C, ASP22D, ASP234C, ASP256C, ASP262D, ASP266D, ASP27C, ASP38D, ASP403C, ASP41D, ASP426D, ASP445C, ASP454C, ASP454D, ASP462C, ASP6D, ASP77C, CYS113D, CYS138D, CYS153D, CYS154C, CYS249C, CYS471C, CYS62C, CYS70D, CYS88C, CYS95D, GLN119C, GLN129D, GLN136D, GLN18D, GLN191C, GLN252C, GLN268D, GLN37D, GLN3D, GLN432C, GLN45D, GLN476C, GLN4D, GLN53C, GLN53D, GLN58D, GLN71D, GLN90C, GLN93D, GLU109D, GLU120C, GLU120D, GLU137C, GLU139C, GLU153C, GLU156D, GLU184C, GLU18C, GLU22C, GLU243C, GLU244C, GLU259D, GLU261C, GLU263C, GLU32D, GLU334C, GLU336C, GLU33D, GLU380C, GLU408C, GLU410C, GLU411C, GLU427C, GLU42D, GLU440C, GLU480C, GLU51D, GLU54D, GLU60D, GLY102C, GLY105C, GLY127C, GLY134D, GLY147C, GLY157C, GLY159D, GLY160C, GLY185C, GLY188C, GLY191D, GLY232C, GLY233C, GLY255C, GLY257C, GLY267D, GLY30D, GLY406C, GLY424C, GLY424D, GLY435C, GLY448C, GLY448D, GLY452C, GLY455C, GLY55C, GLY61C, GLY66C, GLY69C, GLY74D, GLY84C, GLY87C, GLY89C, GLY91D, GLY94D, GLY95C, HIS106D, HIS193D, HIS396D, HIS429D, HIS442C, HIS451C, HIS457D, HIS477D, HIS478D, HIS480D, HIS80C, HIS83C, HIS90D, ILE101C, ILE123C, ILE135C, ILE147D, ILE148C, ILE156C, ILE158D, ILE159C, ILE197C, ILE225C, ILE231C, ILE240C, ILE259C, ILE262C, ILE40D, ILE425C, ILE430C, ILE436C, ILE451D, ILE458C, ILE59C, ILE79C, ILE81C, ILE8D, LEU131C, LEU134C, LEU135D, LEU141C, LEU144C, LEU14D, LEU158C, LEU16D, LEU193C, LEU241C, LEU242C, LEU24D, LEU261D, LEU264C, LEU427D, LEU475C, LEU55D, LEU56C, LEU62D, LEU73D, LYS121C, LYS129C, LYS130C, LYS132D, LYS133C, LYS139D, LYS143D, LYS146C, LYS176C, LYS21D, LYS23C, LYS26D, LYS27D, LYS330C, LYS341C, LYS34D, LYS39D, LYS414C, LYS426C, LYS428C, LYS433C, LYS449D, LYS474C, LYS50C, LYS51C, LYS68C, LYS68D, LYS76C, LYS7D, LYS9D, MET112C, MET118D, MET131D, MET154D, MET23D, MET271D, MET434C, MET465C, MET57C, MET86D, PHE103D, PHE107D, PHE109C, PHE114C, PHE118C, PHE142C, PHE15D, PHE174D, PHE186C, PHE189D, PHE216C, PHE230D, PHE269D, PHE31D, PHE381C, PHE409C, PHE429C, PHE431C, PHE44D, PHE450D, PHE453C, PHE456C, PHE459C, PHE471D, PHE474D, PHE57D, PHE99D, PRO110D, PRO13D, PRO143C, PRO155C, PRO187D, PRO21C, PRO264D, PRO333C, PRO36D, PRO449C, PRO472D, PRO54C, PRO66D, PRO72D, PRO85C, PRO87D, SER101D, SER112D, SER115D, SER116C, SER117D, SER11D, SER188D, SER190C, SER192D, SER218C, SER237C, SER238C, SER254C, SER258C, SER260C, SER2D, SER432D, SER443C, SER446D, SER447C, SER52C, SER67C, SER82C, SER92C, SER92D, THR103C, THR104C, THR111C, THR115C, THR119D, THR140C, THR141D, THR152D, THR215C, THR219C, THR263D, THR405C, THR47D, THR48D, THR58C, THR63D, TRP236C, TRP253C, TRP335C, TRP370D, TRP428D, TRP444C, TRP46D, TRP472C, TYR100C, TYR102D, TYR12D, TYR142D, TYR20C, TYR20D, TYR272D, TYR331C, TYR342C, TYR35D, TYR407C, TYR446C, TYR447D, TYR450C, TYR52D, TYR64C, TYR88D, TYR91C, TYR98D, TYR99C, VAL106C, VAL111D, VAL114D, VAL124C, VAL124D, VAL138C, VAL157D, VAL16C, VAL189C, VAL190D, VAL19C, VAL223C, VAL250C, VAL260D, VAL268C, VAL338C, VAL339C, VAL404C, VAL43D, VAL5D, VAL64D, VAL70C, VAL86C, VAL89D, VAL96D
• C-G: ALA136G, ALA61G, ALA62G, ALA64G, ALA98G, ARG100G, ARG140G, ARG182C, ARG187C, ARG203C, ASN107G, ASN142G, ASN173G, ASN49C, ASP128C, ASP161C, ASP162C, ASP200C, ASP69G, CYS132G, CYS154C, CYS183C, CYS97G, GLU111G, GLU141G, GLU164C, GLU184C, GLU63G, GLU68G, GLY101G, GLY126C, GLY133G, GLY134G, GLY157C, GLY160C, GLY175G, GLY188C, GLY65G, GLY96G, GLY99G, HIS196C, HIS383C, ILE103G, ILE123C, ILE139G, ILE156C, ILE159C, ILE163C, ILE197C, LEU158C, LEU193C, LYS129C, LYS168C, LYS170G, LYS50C, LYS51C, MET137G, PHE108G, PHE135G, PHE186C, PRO155C, SER152C, SER165C, SER174G, SER190C, SER192C, THR104G, THR66G, TYR171G, VAL124C, VAL131G, VAL166C, VAL169C, VAL189C, VAL67G
• C-H: ALA105H, ALA61H, ALA62H, ALA64H, ALA98H, ARG100H, ASN107H, ASP122C, ASP128C, ASP161C, ASP162C, CYS97H, GLN119C, GLU120C, GLU59H, GLU63H, GLU68H, GLU92H, GLY101H, GLY126C, GLY127C, GLY160C, GLY65H, GLY89H, GLY90H, GLY94H, GLY96H, GLY99H, ILE103H, ILE123C, ILE159C, ILE57H, LEU158C, LYS121C, LYS129C, MET58H, MET60H, PHE108H, PHE118C, PHE125C, PRO155C, PRO40H, PRO91H, SER88H, THR104H, THR56H, THR66H, VAL102H, VAL124C, VAL67H, VAL95H
• D-G: ALA105G, ALA122D, ALA123D, ALA155D, ALA164D, ALA61G, ALA62G, ALA64G, ALA98G, ARG100G, ASN107G, ASP121D, ASP160D, ASP161D, CYS97G, GLN128D, GLN129D, GLU120D, GLU59G, GLU63G, GLU68G, GLU92G, GLY101G, GLY126D, GLY127D, GLY159D, GLY65G, GLY89G, GLY90G, GLY94G, GLY96G, GLY99G, ILE103G, ILE158D, ILE57G, MET118D, MET154D, MET58G, MET60G, PHE108G, PHE125D, PHE165D, PRO40G, PRO91G, SER88G, THR104G, THR119D, THR56G, THR66G, VAL102G, VAL124D, VAL157D, VAL67G, VAL95G
• D-H: ALA123D, ALA136H, ALA155D, ALA164D, ALA172H, ALA64H, ARG100H, ARG140H, ARG206D, ARG401D, ASN107H, ASN142H, ASN163D, ASN167D, ASN168D, ASN173H, ASN199D, ASN399D, ASP160D, ASP161D, ASP69H, CYS132H, CYS153D, CYS97H, GLN128D, GLN71D, GLU110H, GLU111H, GLU112H, GLU141H, GLU156D, GLU172D, GLU202D, GLU299D, GLU63H, GLU68H, GLY101H, GLY113H, GLY126D, GLY133H, GLY134H, GLY159D, GLY175H, GLY191D, GLY65H, GLY96H, GLY99H, HIS185D, ILE103H, ILE139H, ILE158D, ILE166D, ILE255H, LEU162D, LEU210D, LYS132D, LYS170D, LYS170H, LYS171D, LYS211D, LYS300D, LYS303D, LYS400D, MET137H, MET154D, PHE125D, PHE135H, PHE165D, PHE183D, PHE189D, PRO187D, SER169D, SER174H, SER176H, SER188D, THR104H, THR151D, THR152D, THR186D, THR195D, THR66H, TYR171H, VAL124D, VAL131H, VAL157D, VAL169H, VAL177H, VAL190D, VAL67H
• E-F: ALA136E, ALA136F, ALA157F, ALA160F, ALA220E, ALA220F, ALA42E, ALA42F, ALA53E, ALA53F, ALA98E, ALA98F, ARG100E, ARG100F, ARG140E, ARG140F, ARG187E, ARG187F, ARG213E, ARG213F, ARG219E, ARG219F, ARG223E, ARG223F, ARG224E, ARG224F, ARG46E, ARG46F, ASN162F, ASN163E, ASN163F, ASN185E, ASN185F, ASN215E, ASN215F, ASP129E, ASP129F, ASP190E, ASP190F, ASP262E, ASP262F, ASP39E, ASP39F, ASP43E, ASP43F, CYS132E, CYS132F, CYS97E, CYS97F, GLN218E, GLN218F, GLU154E, GLU154F, GLU221E, GLU221F, GLU263E, GLU265E, GLU266E, GLU270E, GLU92E, GLU92F, GLY11E, GLY11F, GLY128E, GLY128F, GLY12E, GLY12F, GLY133E, GLY133F, GLY134E, GLY134F, GLY14E, GLY14F, GLY153E, GLY153F, GLY167E, GLY167F, GLY90E, GLY90F, GLY94E, GLY94F, GLY96E, GLY96F, GLY99E, GLY99F, ILE139E, ILE139F, ILE13E, ILE13F, ILE164E, ILE164F, ILE168F, ILE222E, ILE222F, LEU127E, LEU127F, LEU268E, LEU47E, LEU47F, LYS10E, LYS10F, LYS15E, LYS15F, LYS166E, LYS166F, LYS170E, LYS170F, LYS41E, LYS41F, LYS52E, LYS52F, MET137E, MET137F, MET155E, MET155F, MET156E, MET156F, MET261E, MET261F, MET269E, PHE135E, PHE135F, PRO138F, PRO40E, PRO40F, PRO91E, PRO91F, PRO93E, PRO93F, SER152E, SER152F, SER165F, SER16F, SER186E, SER51E, THR17E, THR189E, THR189F, THR260F, TYR159E, TYR159F, TYR171E, TYR171F, TYR8E, TYR8F, VAL102E, VAL102F, VAL126E, VAL126F, VAL130E, VAL130F, VAL131E, VAL131F, VAL217E, VAL217F, VAL95E, VAL95F
• G-H: ALA136G, ALA136H, ALA160G, ALA160H, ALA220H, ALA42G, ALA98G, ALA98H, ARG100G, ARG100H, ARG140G, ARG140H, ARG187G, ARG187H, ARG213G, ARG213H, ARG219G, ARG219H, ARG223G, ARG223H, ARG224G, ARG224H, ARG46G, ARG46H, ASN162G, ASN162H, ASN163G, ASN163H, ASN188G, ASN215G, ASN215H, ASP129G, ASP129H, ASP190G, ASP262G, ASP262H, ASP39G, ASP39H, ASP43G, ASP43H, CYS132G, CYS132H, CYS38G, CYS97G, CYS97H, GLN218G, GLN218H, GLU154G, GLU154H, GLU221G, GLU221H, GLU263G, GLU265G, GLU266G, GLU92G, GLU92H, GLY11G, GLY11H, GLY128G, GLY128H, GLY12G, GLY12H, GLY133G, GLY133H, GLY134G, GLY134H, GLY14G, GLY14H, GLY153G, GLY167G, GLY167H, GLY272G, GLY90G, GLY90H, GLY94G, GLY94H, GLY96G, GLY96H, GLY99G, GLY99H, ILE139G, ILE139H, ILE13G, ILE13H, ILE164G, ILE164H, ILE168G, ILE168H, ILE222G, ILE222H, LEU127G, LEU127H, LEU195G, LEU264G, LEU268G, LEU47H, LYS10G, LYS10H, LYS15G, LYS15H, LYS166G, LYS166H, LYS170G, LYS170H, LYS41G, LYS41H, LYS52G, LYS52H, MET137G, MET137H, MET155G, MET155H, MET156G, MET156H, MET261G, MET261H, MET269G, PHE135G, PHE135H, PRO138G, PRO258G, PRO40G, PRO40H, PRO91G, PRO91H, PRO93G, PRO93H, SER152G, SER165G, SER165H, SER16H, SER186G, SER51H, THR189G, THR189H, THR260G, THR260H, TYR159G, TYR159H, TYR171G, TYR171H, TYR8G, TYR8H, VAL102G, VAL102H, VAL126G, VAL126H, VAL130G, VAL130H, VAL131G, VAL131H, VAL169G, VAL169H, VAL217G, VAL217H, VAL95G, VAL95H