2AFI

crystal structure of mgadp bound av2-av1 complex

• Total interactions analyzed: 120
• Total true interactions: 33
• Strongest Interaction:
  • Chains: B-D
  • Int. Res.: 263
  • Norm. En. per Res.: -4.2614
• Hub Node: B(6)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-232.5286	-58.1468	-1290.97	-1581.6454	405	77	38	52266	17	119	100
A-D	-15.8532	-61.2634	-338.148	-415.2646	134	17	6	13057	4	37	42
A-E	-20.342	-27.7717	-30.3413	-78.455	52	4	0	1874	2	32	12
A-F	-8.5553	-20.6715	-79.7801	-109.0068	51	4	2	3446	1	18	12
B-C	-30.8005	-59.9726	-328.405	-419.1782	134	15	7	12897	4	36	43
B-D	-163.7053	-129.4335	-827.606	-1120.7448	263	38	8	32082	27	180	169
B-E	0.0	-1.5914	-67.1556	-68.747	52	11	2	3507	0	3	16
B-F	0.0	-2.3988	-3.4287	-5.8274	20	0	0	380	0	7	3
B-I	0.0	3.291	-7.111	-3.82	17	0	1	568	0	11	11
B-J	-7.3263	0.1628	-12.0012	-19.1647	30	1	0	800	2	22	19
C-D	-255.789	-57.6697	-1319.81	-1633.2688	410	81	39	53196	16	120	102
C-G	-11.1251	-30.1655	-47.8277	-89.1182	54	1	0	2557	2	36	17
C-H	0.0	-0.8024	-33.4601	-34.2625	36	3	1	1740	0	9	8
D-G	0.0	-5.3972	-32.4936	-37.8908	38	10	1	2441	0	4	11
D-H	-16.2334	5.8121	-10.063	-20.4843	31	2	0	813	0	9	3
E-F	-13.4984	-48.013	-258.287	-319.7984	142	44	5	12997	6	51	32
F-L	-12.0258	5.5186	-53.9857	-60.493	60	13	1	3421	0	29	30
G-H	-58.1938	-17.336	-264.078	-339.6077	129	23	5	11687	2	37	22
I-J	-245.5569	-56.5837	-1309.44	-1611.5806	408	79	39	52985	17	120	101
I-L	-33.171	-62.0758	-343.248	-438.4949	133	18	6	13148	4	40	42
I-M	0.0	-12.9291	-12.9894	-25.9185	44	0	0	1209	0	31	11
I-N	-6.5126	-28.9592	-46.2043	-81.6761	44	4	1	2569	1	19	15
J-K	-44.4106	-59.9302	-322.069	-426.4097	134	21	7	12775	4	37	42
J-L	-178.4206	-127.4523	-832.613	-1138.4859	268	39	8	32116	26	180	169
J-M	0.0	-2.6914	-43.6619	-46.3533	45	5	2	2562	0	4	19
J-N	0.0	0.0	-3.0595	-3.0595	19	0	0	372	0	5	3
K-L	-246.8566	-52.8279	-1319.81	-1619.4945	410	70	39	52994	17	120	101
K-O	-18.5202	-62.3834	-41.0711	-121.9747	63	10	0	2674	9	50	18
K-P	-8.7436	4.6565	-69.1885	-73.2756	50	11	2	3409	0	19	16
L-O	0.0	-26.3929	-33.5856	-59.9785	28	5	1	1794	1	3	7
L-P	0.0	0.0	-1.0186	-1.0186	11	0	0	185	0	2	2
M-N	-21.9745	-21.1914	-182.202	-225.3678	131	36	3	10119	4	37	18
O-P	-27.4259	-17.0495	-249.897	-294.3724	123	24	5	11368	2	39	21

Interface residues

• A-B: ALA108A, ALA10B, ALA122B, ALA123B, ALA132A, ALA140B, ALA155B, ALA217A, ALA235A, ALA24A, ALA251A, ALA25B, ALA265B, ALA337A, ALA340A, ALA457A, ALA460A, ALA477A, ALA61B, ALA63A, ALA65A, ALA67B, ALA69B, ALA94A, ALA97B, ARG100B, ARG105B, ARG108B, ARG187A, ARG210A, ARG239A, ARG248A, ARG25A, ARG270B, ARG28A, ARG28B, ARG345A, ARG431B, ARG453B, ARG461A, ARG481B, ARG59B, ARG60A, ARG93A, ARG96A, ARG97A, ASN104B, ASN107A, ASN113A, ASN130B, ASN137B, ASN145A, ASN230A, ASN397B, ASN445B, ASN56B, ASN65B, ASP116B, ASP117A, ASP121B, ASP122A, ASP133B, ASP136A, ASP17B, ASP19B, ASP222A, ASP22B, ASP234A, ASP256A, ASP262B, ASP266B, ASP27A, ASP29B, ASP38B, ASP403A, ASP41B, ASP426B, ASP445A, ASP454A, ASP454B, ASP462A, ASP6B, ASP77A, CYS113B, CYS138B, CYS153B, CYS154A, CYS249A, CYS62A, CYS70B, CYS88A, CYS95B, GLN119A, GLN129B, GLN136B, GLN18B, GLN191A, GLN252A, GLN268B, GLN37B, GLN3B, GLN432A, GLN45B, GLN476A, GLN4B, GLN53A, GLN53B, GLN58B, GLN71B, GLN90A, GLN93B, GLU109B, GLU120A, GLU120B, GLU137A, GLU139A, GLU153A, GLU156B, GLU184A, GLU18A, GLU22A, GLU243A, GLU244A, GLU259B, GLU261A, GLU263A, GLU32B, GLU334A, GLU336A, GLU33B, GLU380A, GLU408A, GLU410A, GLU411A, GLU427A, GLU42B, GLU440A, GLU51B, GLU54B, GLU60B, GLY102A, GLY105A, GLY127A, GLY134B, GLY157A, GLY159B, GLY160A, GLY185A, GLY188A, GLY191B, GLY232A, GLY233A, GLY255A, GLY257A, GLY267B, GLY30B, GLY406A, GLY424A, GLY424B, GLY435A, GLY448A, GLY448B, GLY452A, GLY455A, GLY55A, GLY61A, GLY66A, GLY69A, GLY74B, GLY84A, GLY87A, GLY89A, GLY91B, GLY94B, GLY95A, HIS106B, HIS193B, HIS396B, HIS429B, HIS442A, HIS451A, HIS457B, HIS477B, HIS478B, HIS83A, HIS90B, ILE101A, ILE123A, ILE135A, ILE147B, ILE148A, ILE156A, ILE158B, ILE159A, ILE197A, ILE225A, ILE231A, ILE240A, ILE259A, ILE262A, ILE40B, ILE425A, ILE430A, ILE436A, ILE451B, ILE458A, ILE59A, ILE79A, ILE81A, ILE8B, LEU131A, LEU134A, LEU135B, LEU141A, LEU144A, LEU14B, LEU158A, LEU16B, LEU193A, LEU241A, LEU24B, LEU261B, LEU264A, LEU427B, LEU475A, LEU55B, LEU56A, LEU62B, LEU73B, LYS121A, LYS129A, LYS130A, LYS132B, LYS133A, LYS139B, LYS143B, LYS146A, LYS176A, LYS209A, LYS21B, LYS23A, LYS267A, LYS26B, LYS27B, LYS330A, LYS341A, LYS34B, LYS39B, LYS414A, LYS426A, LYS428A, LYS433A, LYS449B, LYS474A, LYS50A, LYS51A, LYS68A, LYS68B, LYS76A, LYS7B, LYS9B, MET112A, MET118B, MET131B, MET154B, MET23B, MET271B, MET434A, MET465A, MET57A, MET86B, PHE103B, PHE107B, PHE109A, PHE114A, PHE118A, PHE142A, PHE15B, PHE174B, PHE186A, PHE189B, PHE216A, PHE230B, PHE269B, PHE31B, PHE381A, PHE409A, PHE429A, PHE431A, PHE44B, PHE450B, PHE453A, PHE456A, PHE459A, PHE471B, PHE474B, PHE57B, PHE99B, PRO110B, PRO13B, PRO143A, PRO155A, PRO187B, PRO21A, PRO264B, PRO333A, PRO36B, PRO449A, PRO472B, PRO54A, PRO66B, PRO72B, PRO85A, PRO87B, SER101B, SER112B, SER115B, SER116A, SER117B, SER11B, SER188B, SER190A, SER192A, SER192B, SER218A, SER237A, SER238A, SER254A, SER258A, SER260A, SER2B, SER432B, SER443A, SER446B, SER447A, SER52A, SER82A, SER92A, SER92B, THR103A, THR104A, THR111A, THR115A, THR119B, THR140A, THR141B, THR152B, THR219A, THR263B, THR405A, THR47B, THR48B, THR58A, THR63B, TRP236A, TRP335A, TRP428B, TRP444A, TRP46B, TRP472A, TYR100A, TYR102B, TYR12B, TYR142B, TYR20A, TYR20B, TYR272B, TYR331A, TYR342A, TYR35B, TYR407A, TYR446A, TYR447B, TYR450A, TYR52B, TYR64A, TYR88B, TYR91A, TYR98B, TYR99A, VAL106A, VAL111B, VAL114B, VAL124A, VAL124B, VAL138A, VAL157B, VAL16A, VAL189A, VAL190B, VAL19A, VAL223A, VAL250A, VAL260B, VAL268A, VAL338A, VAL339A, VAL404A, VAL43B, VAL5B, VAL64B, VAL70A, VAL86A, VAL89B, VAL96B
• A-D: ALA108A, ALA342D, ALA477A, ALA514D, ALA94A, ARG345A, ARG348D, ARG350D, ARG439A, ARG461A, ARG523D, ARG93A, ARG96A, ARG97A, ASN107A, ASN230A, ASN468A, ASN469A, ASN518D, ASN98A, ASP256A, ASP323D, ASP326D, ASP353D, ASP357D, ASP445A, ASP462A, ASP464A, ASP516D, ASP520D, CYS388D, CYS471A, GLN432A, GLN476A, GLN513D, GLN90A, GLU327D, GLU347D, GLU385D, GLU440A, GLU480A, GLY102A, GLY105A, GLY232A, GLY233A, GLY349D, GLY364D, GLY387D, GLY435A, GLY511D, GLY95A, HIS359D, HIS363D, HIS519D, ILE101A, ILE340D, ILE425A, ILE436A, LEU322D, LEU329D, LEU344D, LEU351D, LEU362D, LEU383D, LEU384D, LEU386D, LEU467A, LEU475A, LEU502D, LEU505D, LEU521D, LYS331D, LYS341A, LYS346D, LYS365D, LYS381D, LYS417D, LYS428A, LYS433A, LYS473A, LYS474A, LYS76A, MET330D, MET354D, MET355D, MET434A, MET463A, MET465A, MET512D, PHE328D, PHE382D, PHE429A, PHE431A, PHE438A, PRO339D, PRO341D, PRO414D, PRO437A, PRO449A, PRO470A, PRO478A, SER333D, SER358D, SER413D, SER443A, SER447A, SER92A, THR103A, THR104A, THR111A, THR325D, THR345D, THR356D, THR360D, THR466A, THR509D, THR515D, TRP236A, TRP324D, TRP361D, TRP444A, TRP472A, TRP479A, TYR100A, TYR342A, TYR415D, TYR446A, TYR487D, TYR517D, TYR91A, TYR99A, VAL106A, VAL352D, VAL522D
• A-E: ALA64E, ARG100E, ARG140E, ARG182A, ARG187A, ASN107E, ASN173E, ASN49A, ASP161A, ASP162A, ASP27A, ASP69E, CYS154A, CYS97E, GLN53A, GLU111E, GLU164A, GLU184A, GLU63E, GLU68E, GLY133E, GLY134E, GLY157A, GLY160A, GLY65E, GLY96E, ILE103E, ILE156A, ILE159A, ILE163A, LEU158A, LEU193A, LYS168A, LYS170E, LYS23A, LYS30A, LYS50A, LYS51A, PHE186A, PRO155A, PRO54A, SER165A, SER174E, SER48A, SER52A, THR104E, THR66E, TYR171E, VAL169A, VAL189A, VAL67E, VAL95E
• A-F: ALA136F, ARG100F, ARG140F, ARG182A, ASN107F, ASP122A, ASP128A, ASP161A, ASP162A, CYS132F, CYS97F, GLU110F, GLU111F, GLU120A, GLU141F, GLU164A, GLY101F, GLY126A, GLY127A, GLY133F, GLY134F, GLY160A, GLY94F, GLY96F, GLY99F, ILE103F, ILE106F, ILE123A, ILE156A, ILE159A, ILE163A, LEU158A, LYS121A, LYS129A, LYS133A, LYS143F, MET137F, MET58F, PHE108F, PHE118A, PHE125A, PRO138F, PRO155A, PRO91F, SER165A, THR104F, THR66F, VAL124A, VAL166A, VAL67F, VAL95F
• B-C: ALA108C, ALA342B, ALA477C, ALA514B, ALA94C, ARG345C, ARG348B, ARG350B, ARG439C, ARG461C, ARG523B, ARG93C, ARG96C, ARG97C, ASN107C, ASN230C, ASN468C, ASN469C, ASN518B, ASN98C, ASP256C, ASP323B, ASP326B, ASP353B, ASP357B, ASP445C, ASP462C, ASP464C, ASP516B, ASP520B, CYS388B, CYS471C, GLN432C, GLN476C, GLN513B, GLN90C, GLU327B, GLU347B, GLU385B, GLU440C, GLU480C, GLY102C, GLY105C, GLY232C, GLY233C, GLY349B, GLY364B, GLY387B, GLY435C, GLY511B, GLY95C, HIS359B, HIS363B, HIS519B, ILE101C, ILE340B, ILE425C, ILE436C, LEU322B, LEU329B, LEU344B, LEU351B, LEU362B, LEU383B, LEU384B, LEU386B, LEU467C, LEU475C, LEU502B, LEU505B, LEU521B, LYS331B, LYS341C, LYS346B, LYS365B, LYS381B, LYS417B, LYS428C, LYS433C, LYS473C, LYS474C, LYS76C, MET330B, MET354B, MET355B, MET463C, MET465C, MET512B, PHE328B, PHE382B, PHE429C, PHE431C, PHE438C, PRO339B, PRO341B, PRO414B, PRO437C, PRO449C, PRO470C, PRO478C, SER333B, SER343B, SER358B, SER413B, SER443C, SER447C, SER92C, THR103C, THR104C, THR111C, THR325B, THR345B, THR356B, THR360B, THR466C, THR509B, THR515B, TRP236C, TRP324B, TRP361B, TRP444C, TRP472C, TRP479C, TYR100C, TYR342C, TYR415B, TYR446C, TYR487B, TYR517B, TYR91C, TYR99C, VAL106C, VAL352B, VAL522B
• B-D: ALA10B, ALA10D, ALA265B, ALA265D, ALA273B, ALA273D, ALA342B, ALA514B, ALA514D, ARG105B, ARG105D, ARG108B, ARG108D, ARG238B, ARG238D, ARG270B, ARG270D, ARG28B, ARG28D, ARG348B, ARG348D, ARG350B, ARG350D, ARG366B, ARG366D, ARG431B, ARG431D, ARG453B, ARG453D, ARG468B, ARG468D, ARG476B, ARG476D, ARG481B, ARG481D, ARG504B, ARG504D, ARG510B, ARG510D, ARG523B, ARG523D, ASN104B, ASN445B, ASN445D, ASN499B, ASN499D, ASN518B, ASN518D, ASP17B, ASP17D, ASP262B, ASP262D, ASP266B, ASP266D, ASP353B, ASP353D, ASP357B, ASP357D, ASP41B, ASP41D, ASP440B, ASP440D, ASP454B, ASP454D, ASP475B, ASP475D, ASP506B, ASP506D, ASP516B, ASP516D, ASP520B, ASP520D, GLN37B, GLN37D, GLN452B, GLN452D, GLN492B, GLN492D, GLN513B, GLN513D, GLU109B, GLU109D, GLU258B, GLU258D, GLU259B, GLU259D, GLU347B, GLU347D, GLU461B, GLU461D, GLU463B, GLU463D, GLU488B, GLU488D, GLU503B, GLU503D, GLU507B, GLU507D, GLU508B, GLU508D, GLY267B, GLY267D, GLY274B, GLY274D, GLY349B, GLY349D, GLY448B, GLY448D, GLY511B, GLY511D, HIS106B, HIS106D, HIS359B, HIS359D, HIS457B, HIS457D, HIS477B, HIS477D, HIS478B, HIS478D, HIS480B, HIS480D, HIS519B, HIS519D, ILE40B, ILE40D, ILE451B, ILE451D, ILE467B, ILE467D, ILE473B, ILE473D, ILE501B, ILE501D, LEU14B, LEU14D, LEU16B, LEU16D, LEU234B, LEU234D, LEU24B, LEU24D, LEU261B, LEU261D, LEU351B, LEU351D, LEU362B, LEU362D, LEU456B, LEU456D, LEU466B, LEU466D, LEU479B, LEU479D, LEU494B, LEU494D, LEU497D, LEU502B, LEU502D, LEU505B, LEU505D, LEU521B, LEU521D, LYS21B, LYS21D, LYS346B, LYS346D, LYS34B, LYS34D, LYS438B, LYS438D, LYS449B, LYS449D, LYS458B, LYS458D, LYS460B, LYS460D, LYS7B, LYS7D, MET354B, MET354D, MET355B, MET355D, MET491B, MET491D, MET512B, MET512D, PHE107B, PHE107D, PHE15B, PHE15D, PHE435B, PHE435D, PHE44B, PHE44D, PHE450B, PHE450D, PHE474B, PHE474D, PRO110B, PRO110D, PRO13B, PRO13D, PRO264B, PRO264D, PRO465B, PRO465D, PRO472B, PRO472D, SER101B, SER101D, SER11B, SER11D, SER358B, SER358D, SER446B, SER446D, SER482B, SER482D, SER500B, SER500D, THR263B, THR263D, THR345B, THR345D, THR356B, THR356D, THR360B, THR360D, THR455B, THR455D, THR495B, THR495D, THR496B, THR496D, THR509B, THR509D, THR515B, THR515D, TRP361B, TRP361D, TRP428B, TRP428D, TYR102B, TYR102D, TYR12B, TYR12D, TYR35B, TYR35D, TYR447B, TYR447D, TYR517B, TYR517D, VAL260B, VAL260D, VAL352B, VAL352D, VAL464B, VAL464D, VAL498B, VAL498D, VAL522B, VAL522D
• B-E: ALA105E, ALA122B, ALA123B, ALA61E, ALA62E, ALA64E, ALA98E, ARG100E, ASN107E, ASN130B, ASP121B, ASP133B, ASP160B, ASP69E, CYS97E, GLN128B, GLN129B, GLU120B, GLU172B, GLU59E, GLU63E, GLU68E, GLU92E, GLY101E, GLY126B, GLY159B, GLY65E, GLY89E, GLY90E, GLY94E, GLY96E, ILE103E, ILE158B, ILE57E, LEU70E, LYS132B, MET118B, MET58E, MET60E, PHE125B, PHE165B, PRO91E, SER117B, SER88E, THR104E, THR119B, THR56E, THR66E, VAL124B, VAL157B, VAL67E, VAL95E
• B-F: ALA164B, ARG100F, ARG140F, ASN163B, ASN173F, ASP160B, ASP161B, GLU156B, GLU60B, GLU68F, GLY126B, GLY127B, GLY133F, GLY159B, ILE158B, LYS170F, PHE125B, PHE165B, TYR171F, VAL157B
• B-I: ARG415I, ASN221B, ASP214B, ASP215B, GLU15I, GLU18I, GLY219B, LEU17I, LYS222B, LYS414I, SER220B, TYR20I, TYR407I, VAL16I, VAL19I, VAL217B, VAL218B
• B-J: ALA140J, ASN289B, ASP145J, ASP177J, GLN136J, GLU172J, GLU178J, GLU312B, GLU334B, GLY173J, ILE175J, ILE335B, LYS139J, LYS143J, LYS170J, LYS171J, LYS310B, LYS315B, LYS331B, LYS84J, PHE174J, PHE179J, PRO144J, PRO176J, PRO180J, PRO314B, TRP309B, VAL217B, VAL218B, VAL313B
• C-D: ALA108C, ALA10D, ALA122D, ALA123D, ALA132C, ALA140D, ALA155D, ALA217C, ALA235C, ALA24C, ALA251C, ALA25D, ALA265D, ALA337C, ALA340C, ALA457C, ALA460C, ALA477C, ALA61D, ALA63C, ALA65C, ALA67D, ALA69D, ALA94C, ALA97D, ARG100D, ARG105D, ARG108D, ARG187C, ARG210C, ARG239C, ARG248C, ARG25C, ARG270D, ARG28C, ARG28D, ARG345C, ARG431D, ARG453D, ARG461C, ARG481D, ARG59D, ARG60C, ARG93C, ARG96C, ARG97C, ASN104D, ASN107C, ASN113C, ASN130D, ASN137D, ASN145C, ASN230C, ASN397D, ASN445D, ASN56D, ASN65D, ASP116D, ASP117C, ASP121D, ASP122C, ASP133D, ASP136C, ASP17D, ASP19D, ASP222C, ASP22D, ASP234C, ASP256C, ASP262D, ASP266D, ASP27C, ASP29D, ASP38D, ASP403C, ASP41D, ASP426D, ASP445C, ASP454C, ASP454D, ASP462C, ASP6D, ASP77C, CYS113D, CYS138D, CYS153D, CYS154C, CYS249C, CYS62C, CYS70D, CYS88C, CYS95D, GLN119C, GLN129D, GLN136D, GLN18D, GLN191C, GLN252C, GLN268D, GLN37D, GLN3D, GLN432C, GLN45D, GLN476C, GLN4D, GLN53C, GLN53D, GLN58D, GLN71D, GLN90C, GLN93D, GLU109D, GLU120C, GLU120D, GLU137C, GLU139C, GLU153C, GLU156D, GLU184C, GLU18C, GLU22C, GLU243C, GLU244C, GLU259D, GLU261C, GLU263C, GLU32D, GLU334C, GLU336C, GLU33D, GLU380C, GLU408C, GLU410C, GLU411C, GLU427C, GLU42D, GLU440C, GLU51D, GLU54D, GLU60D, GLY102C, GLY105C, GLY127C, GLY134D, GLY147C, GLY157C, GLY159D, GLY160C, GLY185C, GLY188C, GLY191D, GLY232C, GLY233C, GLY255C, GLY257C, GLY267D, GLY30D, GLY406C, GLY424C, GLY424D, GLY435C, GLY448C, GLY448D, GLY452C, GLY455C, GLY55C, GLY61C, GLY66C, GLY69C, GLY74D, GLY84C, GLY87C, GLY89C, GLY91D, GLY94D, GLY95C, HIS106D, HIS193D, HIS396D, HIS429D, HIS442C, HIS451C, HIS457D, HIS477D, HIS478D, HIS80C, HIS83C, HIS90D, ILE101C, ILE123C, ILE135C, ILE147D, ILE148C, ILE156C, ILE158D, ILE159C, ILE197C, ILE225C, ILE231C, ILE240C, ILE259C, ILE262C, ILE40D, ILE425C, ILE430C, ILE436C, ILE451D, ILE458C, ILE59C, ILE79C, ILE81C, ILE8D, LEU131C, LEU134C, LEU135D, LEU141C, LEU144C, LEU14D, LEU158C, LEU16D, LEU17C, LEU193C, LEU241C, LEU24D, LEU261D, LEU264C, LEU427D, LEU475C, LEU55D, LEU56C, LEU62D, LEU73D, LYS121C, LYS129C, LYS130C, LYS132D, LYS133C, LYS139D, LYS143D, LYS146C, LYS176C, LYS209C, LYS21D, LYS23C, LYS267C, LYS26D, LYS27D, LYS330C, LYS341C, LYS34D, LYS39D, LYS414C, LYS426C, LYS428C, LYS433C, LYS449D, LYS474C, LYS50C, LYS51C, LYS68C, LYS68D, LYS76C, LYS7D, LYS9D, MET112C, MET118D, MET131D, MET154D, MET23D, MET271D, MET434C, MET465C, MET57C, MET86D, PHE103D, PHE107D, PHE109C, PHE114C, PHE118C, PHE142C, PHE15D, PHE174D, PHE186C, PHE189D, PHE216C, PHE230D, PHE269D, PHE31D, PHE381C, PHE409C, PHE429C, PHE431C, PHE44D, PHE450D, PHE453C, PHE456C, PHE459C, PHE471D, PHE474D, PHE57D, PHE99D, PRO110D, PRO13D, PRO143C, PRO144D, PRO155C, PRO187D, PRO21C, PRO264D, PRO333C, PRO36D, PRO449C, PRO472D, PRO54C, PRO66D, PRO72D, PRO85C, PRO87D, SER101D, SER112D, SER115D, SER116C, SER117D, SER11D, SER188D, SER190C, SER192C, SER192D, SER218C, SER237C, SER238C, SER254C, SER258C, SER260C, SER2D, SER432D, SER443C, SER446D, SER447C, SER52C, SER82C, SER92C, SER92D, THR103C, THR104C, THR111C, THR115C, THR119D, THR140C, THR141D, THR152D, THR219C, THR263D, THR265C, THR405C, THR47D, THR48D, THR58C, THR63D, TRP236C, TRP335C, TRP428D, TRP444C, TRP46D, TRP472C, TYR100C, TYR102D, TYR12D, TYR142D, TYR20C, TYR20D, TYR272D, TYR331C, TYR342C, TYR35D, TYR407C, TYR446C, TYR447D, TYR450C, TYR52D, TYR64C, TYR88D, TYR91C, TYR98D, TYR99C, VAL106C, VAL111D, VAL114D, VAL124C, VAL124D, VAL138C, VAL157D, VAL16C, VAL189C, VAL190D, VAL19C, VAL223C, VAL250C, VAL260D, VAL268C, VAL338C, VAL339C, VAL404C, VAL43D, VAL5D, VAL64D, VAL70C, VAL86C, VAL89D, VAL96D
• C-G: ALA172C, ALA172G, ALA64G, ARG100G, ARG140G, ARG182C, ARG187C, ASN107G, ASN173G, ASN49C, ASP128C, ASP161C, ASP162C, ASP27C, ASP69G, GLN53C, GLU111G, GLU141G, GLU164C, GLU184C, GLU68G, GLY133G, GLY157C, GLY160C, GLY175G, GLY65G, ILE103G, ILE156C, ILE159C, ILE163C, LEU158C, LEU193C, LYS129C, LYS168C, LYS170G, LYS23C, LYS26C, LYS30C, LYS50C, LYS51C, MET137G, PHE186C, PRO155C, PRO180C, SER165C, SER174G, SER48C, THR66G, TRP205C, TYR171G, VAL166C, VAL169C, VAL189C, VAL67G
• C-H: ALA61H, ALA62H, ALA64H, ARG100H, ARG182C, ASP122C, ASP128C, ASP161C, ASP162C, ASP69H, CYS97H, GLU120C, GLU68H, GLU92H, GLY101H, GLY126C, GLY157C, GLY160C, GLY65H, GLY94H, GLY96H, ILE103H, ILE123C, ILE159C, ILE57H, LEU158C, LYS121C, LYS129C, MET58H, PHE125C, PRO91H, THR104H, THR66H, VAL124C, VAL67H, VAL95H
• D-G: ALA105G, ALA122D, ALA123D, ALA61G, ALA62G, ALA98G, ARG100G, ASN107G, ASP121D, ASP160D, CYS97G, GLN128D, GLN129D, GLU120D, GLU68G, GLU92G, GLY101G, GLY126D, GLY65G, GLY90G, GLY96G, GLY99G, ILE103G, ILE158D, ILE57G, MET154D, MET58G, PHE125D, PHE165D, PRO91G, THR104G, THR119D, THR66G, VAL102G, VAL124D, VAL157D, VAL67G, VAL95G
• D-H: ALA123D, ALA155D, ALA164D, ARG100H, ARG140H, ASN163D, ASN167D, ASN168D, ASN173H, ASP160D, ASP161D, GLN128D, GLU141H, GLU156D, GLU172D, GLY126D, GLY133H, GLY159D, ILE103H, ILE158D, LYS132D, LYS170H, LYS171D, MET154D, PHE125D, PHE165D, PHE189D, SER174H, TYR171H, VAL124D, VAL157D
• E-F: ALA136E, ALA136F, ALA157E, ALA157F, ALA160E, ALA160F, ALA42E, ALA42F, ALA53E, ALA53F, ALA98E, ALA98F, ARG100E, ARG100F, ARG140E, ARG140F, ARG187E, ARG187F, ARG213E, ARG213F, ARG219E, ARG223E, ARG224E, ARG224F, ARG46E, ARG46F, ASN162E, ASN162F, ASN163E, ASN163F, ASN215E, ASP129E, ASP129F, ASP262E, ASP262F, ASP39E, ASP39F, ASP43E, ASP43F, CYS132E, CYS132F, CYS97E, CYS97F, GLN218E, GLN54E, GLU154E, GLU154F, GLU221E, GLU221F, GLU263F, GLU265E, GLU265F, GLU266E, GLU266F, GLU275F, GLU92E, GLU92F, GLY11E, GLY11F, GLY128E, GLY128F, GLY12E, GLY12F, GLY133E, GLY133F, GLY134E, GLY134F, GLY14E, GLY14F, GLY167E, GLY167F, GLY94E, GLY94F, GLY96E, GLY96F, GLY99E, GLY99F, ILE139E, ILE139F, ILE13E, ILE13F, ILE164E, ILE164F, ILE168E, ILE168F, ILE222E, ILE222F, ILE273F, LEU127E, LEU127F, LEU264E, LEU264F, LYS10E, LYS10F, LYS15E, LYS15F, LYS166E, LYS166F, LYS170E, LYS170F, LYS41E, LYS41F, LYS52E, LYS52F, MET137E, MET137F, MET155E, MET155F, MET156E, MET156F, MET261E, MET261F, MET269E, MET269F, MET274F, PHE135E, PHE135F, PRO258E, PRO258F, PRO40E, PRO40F, PRO91E, PRO91F, PRO93E, PRO93F, SER165E, SER165F, SER16E, SER16F, THR260F, TYR159E, TYR159F, TYR171E, TYR171F, VAL130E, VAL130F, VAL131E, VAL131F, VAL169E, VAL169F, VAL95E, VAL95F
• F-L: ALA198F, ALA200F, ALA242F, ARG191F, ARG245F, ASN201F, ASN221L, ASN250F, ASN286L, ASP193F, ASP214L, ASP215L, ASP249F, ASP283L, GLN206F, GLN338L, GLU192F, GLU194F, GLU246L, GLU279L, GLY180F, GLY181F, GLY204F, GLY219L, GLY248L, GLY250L, GLY337L, HIS209F, ILE183F, ILE196F, ILE197F, ILE208F, LEU182F, LEU195F, LEU243F, LEU244L, LEU252F, LEU253F, LEU288L, LYS216L, LYS222L, LYS223L, LYS246F, LYS251F, MET207F, MET247L, PHE210F, PHE271F, PRO339L, SER220L, SER245L, SER336L, THR205F, TYR148F, TYR251L, VAL217L, VAL218L, VAL247F, VAL249L, VAL254F
• G-H: ALA136G, ALA136H, ALA157G, ALA157H, ALA160G, ALA160H, ALA42G, ALA42H, ALA53G, ALA53H, ALA98G, ALA98H, ARG100G, ARG100H, ARG140G, ARG140H, ARG187G, ARG187H, ARG213G, ARG213H, ARG224G, ARG46G, ARG46H, ASN162G, ASN162H, ASN163G, ASN163H, ASP129G, ASP129H, ASP262G, ASP262H, ASP39G, ASP39H, ASP43G, ASP43H, CYS132G, CYS132H, CYS97G, CYS97H, GLN54G, GLU154G, GLU154H, GLU263H, GLU265H, GLU266H, GLU59G, GLU92G, GLU92H, GLY11G, GLY11H, GLY12G, GLY12H, GLY133G, GLY133H, GLY134G, GLY134H, GLY14G, GLY14H, GLY167G, GLY167H, GLY94G, GLY94H, GLY96G, GLY96H, GLY99G, GLY99H, ILE139G, ILE139H, ILE13G, ILE13H, ILE164G, ILE164H, ILE168G, ILE168H, ILE222G, LEU127G, LEU127H, LEU264H, LEU268H, LYS10G, LYS10H, LYS15G, LYS15H, LYS166G, LYS166H, LYS170G, LYS170H, LYS41G, LYS41H, LYS52G, LYS52H, MET137G, MET137H, MET155G, MET155H, MET156G, MET156H, MET158H, MET261G, MET261H, MET269H, PHE135G, PHE135H, PRO258G, PRO258H, PRO40G, PRO40H, PRO91G, PRO91H, PRO93G, PRO93H, SER165G, SER165H, SER16G, SER16H, THR260H, THR56G, TYR159G, TYR159H, TYR171G, TYR171H, VAL130G, VAL130H, VAL131G, VAL131H, VAL169G, VAL169H, VAL95G, VAL95H
• I-J: ALA108I, ALA10J, ALA122J, ALA123J, ALA132I, ALA140J, ALA155J, ALA217I, ALA235I, ALA24I, ALA251I, ALA25J, ALA265J, ALA337I, ALA340I, ALA457I, ALA460I, ALA477I, ALA61J, ALA63I, ALA65I, ALA67J, ALA69J, ALA94I, ALA97J, ARG100J, ARG105J, ARG108J, ARG187I, ARG210I, ARG239I, ARG248I, ARG25I, ARG270J, ARG28I, ARG28J, ARG345I, ARG431J, ARG453J, ARG461I, ARG481J, ARG59J, ARG60I, ARG93I, ARG96I, ARG97I, ASN104J, ASN107I, ASN113I, ASN130J, ASN137J, ASN145I, ASN230I, ASN397J, ASN445J, ASN56J, ASN65J, ASP116J, ASP117I, ASP121J, ASP122I, ASP133J, ASP136I, ASP17J, ASP19J, ASP222I, ASP22J, ASP234I, ASP256I, ASP262J, ASP266J, ASP27I, ASP29J, ASP38J, ASP403I, ASP41J, ASP426J, ASP445I, ASP454I, ASP454J, ASP462I, ASP6J, ASP77I, CYS113J, CYS138J, CYS153J, CYS154I, CYS249I, CYS62I, CYS70J, CYS88I, CYS95J, GLN119I, GLN129J, GLN136J, GLN18J, GLN191I, GLN252I, GLN268J, GLN37J, GLN3J, GLN432I, GLN45J, GLN476I, GLN4J, GLN53I, GLN53J, GLN58J, GLN71J, GLN90I, GLN93J, GLU109J, GLU120I, GLU120J, GLU137I, GLU139I, GLU153I, GLU156J, GLU184I, GLU18I, GLU22I, GLU243I, GLU244I, GLU259J, GLU261I, GLU263I, GLU32J, GLU334I, GLU336I, GLU33J, GLU380I, GLU408I, GLU410I, GLU411I, GLU427I, GLU42J, GLU440I, GLU51J, GLU54J, GLU60J, GLY102I, GLY105I, GLY127I, GLY134J, GLY147I, GLY157I, GLY159J, GLY160I, GLY185I, GLY188I, GLY191J, GLY232I, GLY233I, GLY255I, GLY257I, GLY267J, GLY30J, GLY406I, GLY424I, GLY424J, GLY435I, GLY448I, GLY448J, GLY452I, GLY455I, GLY55I, GLY61I, GLY66I, GLY69I, GLY74J, GLY84I, GLY87I, GLY89I, GLY91J, GLY94J, GLY95I, HIS106J, HIS193J, HIS396J, HIS429J, HIS442I, HIS451I, HIS457J, HIS477J, HIS478J, HIS80I, HIS83I, HIS90J, ILE101I, ILE123I, ILE135I, ILE147J, ILE148I, ILE156I, ILE158J, ILE159I, ILE197I, ILE225I, ILE231I, ILE240I, ILE259I, ILE262I, ILE40J, ILE425I, ILE430I, ILE436I, ILE451J, ILE458I, ILE59I, ILE79I, ILE81I, ILE8J, LEU131I, LEU134I, LEU135J, LEU141I, LEU144I, LEU14J, LEU158I, LEU16J, LEU193I, LEU241I, LEU242I, LEU24J, LEU261J, LEU264I, LEU427J, LEU475I, LEU55J, LEU56I, LEU62J, LEU73J, LYS121I, LYS129I, LYS130I, LYS132J, LYS133I, LYS139J, LYS143J, LYS146I, LYS176I, LYS209I, LYS21J, LYS23I, LYS267I, LYS26J, LYS27J, LYS330I, LYS341I, LYS34J, LYS39J, LYS414I, LYS426I, LYS428I, LYS433I, LYS449J, LYS474I, LYS50I, LYS51I, LYS68I, LYS68J, LYS76I, LYS7J, LYS9J, MET112I, MET118J, MET131J, MET154J, MET23J, MET271J, MET434I, MET57I, MET86J, PHE103J, PHE107J, PHE109I, PHE114I, PHE118I, PHE142I, PHE15J, PHE174J, PHE186I, PHE189J, PHE216I, PHE230J, PHE269J, PHE31J, PHE381I, PHE409I, PHE429I, PHE431I, PHE44J, PHE450J, PHE453I, PHE456I, PHE459I, PHE471J, PHE474J, PHE57J, PHE99J, PRO110J, PRO13J, PRO143I, PRO144J, PRO155I, PRO187J, PRO21I, PRO264J, PRO333I, PRO36J, PRO449I, PRO472J, PRO54I, PRO66J, PRO72J, PRO85I, PRO87J, SER101J, SER112J, SER115J, SER116I, SER117J, SER11J, SER188J, SER190I, SER192I, SER192J, SER218I, SER237I, SER238I, SER254I, SER258I, SER260I, SER2J, SER432J, SER443I, SER446J, SER447I, SER52I, SER82I, SER92I, SER92J, THR103I, THR104I, THR111I, THR115I, THR119J, THR140I, THR141J, THR152J, THR219I, THR263J, THR265I, THR405I, THR47J, THR48J, THR58I, THR63J, TRP236I, TRP335I, TRP428J, TRP444I, TRP46J, TRP472I, TYR100I, TYR102J, TYR12J, TYR142J, TYR20I, TYR20J, TYR272J, TYR331I, TYR342I, TYR35J, TYR407I, TYR446I, TYR447J, TYR450I, TYR52J, TYR64I, TYR88J, TYR91I, TYR98J, TYR99I, VAL106I, VAL111J, VAL114J, VAL124I, VAL124J, VAL138I, VAL157J, VAL16I, VAL189I, VAL190J, VAL19I, VAL223I, VAL250I, VAL260J, VAL268I, VAL338I, VAL339I, VAL43J, VAL5J, VAL64J, VAL70I, VAL86I, VAL89J, VAL96J
• I-L: ALA108I, ALA342L, ALA477I, ALA514L, ALA94I, ARG345I, ARG348L, ARG350L, ARG439I, ARG461I, ARG523L, ARG93I, ARG96I, ARG97I, ASN107I, ASN230I, ASN468I, ASN469I, ASN518L, ASN98I, ASP256I, ASP323L, ASP326L, ASP353L, ASP357L, ASP445I, ASP462I, ASP464I, ASP516L, ASP520L, CYS388L, CYS471I, GLN432I, GLN476I, GLN513L, GLN90I, GLU327L, GLU347L, GLU385L, GLU440I, GLU480I, GLY102I, GLY105I, GLY232I, GLY233I, GLY349L, GLY364L, GLY387L, GLY435I, GLY511L, GLY95I, HIS359L, HIS363L, HIS519L, ILE101I, ILE340L, ILE425I, ILE436I, LEU322L, LEU329L, LEU344L, LEU351L, LEU362L, LEU383L, LEU384L, LEU386L, LEU467I, LEU475I, LEU502L, LEU505L, LEU521L, LYS331L, LYS341I, LYS346L, LYS365L, LYS381L, LYS417L, LYS428I, LYS433I, LYS473I, LYS474I, LYS76I, MET330L, MET354L, MET355L, MET463I, MET465I, MET512L, PHE328L, PHE382L, PHE429I, PHE431I, PHE438I, PRO339L, PRO341L, PRO414L, PRO437I, PRO449I, PRO470I, PRO478I, SER333L, SER358L, SER413L, SER443I, SER447I, SER92I, THR103I, THR104I, THR111I, THR325L, THR345L, THR356L, THR360L, THR466I, THR509L, THR515L, TRP236I, TRP324L, TRP361L, TRP444I, TRP472I, TRP479I, TYR100I, TYR342I, TYR415L, TYR446I, TYR487L, TYR517L, TYR91I, TYR99I, VAL106I, VAL352L, VAL522L
• I-M: ALA64M, ARG100M, ARG140M, ARG182I, ARG187I, ARG203I, ASN173M, ASN49I, ASP161I, ASP162I, ASP204I, ASP27I, ASP69M, CYS97M, GLN53I, GLU111M, GLU164I, GLU184I, GLU68M, GLY133M, GLY157I, GLY160I, GLY65M, GLY96M, ILE103M, ILE156I, ILE159I, ILE163I, LEU158I, LYS168I, LYS170M, LYS23I, LYS26I, LYS50I, LYS51I, PHE186I, PRO54I, SER165I, SER174M, THR66M, TYR171M, VAL169I, VAL189I, VAL67M
• I-N: ARG100N, ARG140N, ARG182I, ASN107N, ASN142N, ASP122I, ASP128I, ASP161I, ASP162I, CYS97N, GLU110N, GLU111N, GLU120I, GLU141N, GLU164I, GLY101N, GLY126I, GLY127I, GLY133N, GLY134N, GLY160I, GLY94N, GLY96N, ILE103N, ILE106N, ILE123I, ILE156I, ILE159I, LEU158I, LYS121I, LYS129I, LYS133I, LYS143N, MET137N, MET58N, PHE118I, PHE125I, PRO155I, SER165I, THR104N, THR66N, VAL124I, VAL67N, VAL95N
• J-K: ALA108K, ALA342J, ALA477K, ALA514J, ALA94K, ARG345K, ARG348J, ARG350J, ARG439K, ARG461K, ARG523J, ARG93K, ARG96K, ARG97K, ASN107K, ASN230K, ASN468K, ASN469K, ASN518J, ASN98K, ASP256K, ASP323J, ASP326J, ASP353J, ASP357J, ASP445K, ASP462K, ASP464K, ASP516J, ASP520J, CYS388J, CYS471K, GLN432K, GLN476K, GLN513J, GLN90K, GLU327J, GLU347J, GLU385J, GLU440K, GLU480K, GLY102K, GLY105K, GLY232K, GLY233K, GLY349J, GLY364J, GLY387J, GLY435K, GLY448K, GLY511J, GLY95K, HIS359J, HIS363J, HIS519J, ILE101K, ILE340J, ILE425K, ILE436K, LEU322J, LEU329J, LEU344J, LEU351J, LEU362J, LEU383J, LEU384J, LEU386J, LEU467K, LEU475K, LEU502J, LEU505J, LEU521J, LYS331J, LYS341K, LYS346J, LYS365J, LYS381J, LYS417J, LYS428K, LYS433K, LYS473K, LYS474K, LYS76K, MET330J, MET354J, MET355J, MET463K, MET465K, MET512J, PHE328J, PHE382J, PHE429K, PHE431K, PHE438K, PRO339J, PRO341J, PRO414J, PRO437K, PRO449K, PRO470K, PRO478K, SER333J, SER343J, SER358J, SER413J, SER443K, SER447K, SER92K, THR103K, THR104K, THR111K, THR325J, THR345J, THR356J, THR360J, THR466K, THR509J, THR515J, TRP236K, TRP361J, TRP444K, TRP472K, TRP479K, TYR100K, TYR342K, TYR415J, TYR446K, TYR487J, TYR517J, TYR91K, TYR99K, VAL106K, VAL352J, VAL522J
• J-L: ALA10J, ALA10L, ALA265J, ALA265L, ALA273J, ALA273L, ALA514J, ALA514L, ARG105J, ARG105L, ARG108J, ARG108L, ARG238J, ARG238L, ARG270J, ARG270L, ARG28J, ARG28L, ARG348J, ARG348L, ARG350J, ARG350L, ARG366J, ARG366L, ARG431J, ARG431L, ARG453J, ARG453L, ARG468J, ARG468L, ARG476J, ARG476L, ARG481J, ARG481L, ARG504J, ARG504L, ARG510J, ARG510L, ARG523J, ARG523L, ASN104J, ASN445J, ASN445L, ASN499J, ASN499L, ASN518J, ASN518L, ASP17J, ASP17L, ASP262J, ASP262L, ASP266J, ASP266L, ASP353J, ASP353L, ASP357J, ASP357L, ASP41J, ASP41L, ASP440J, ASP440L, ASP454J, ASP454L, ASP475J, ASP475L, ASP506J, ASP506L, ASP516J, ASP516L, ASP520J, ASP520L, GLN37J, GLN37L, GLN452J, GLN452L, GLN492J, GLN492L, GLN513J, GLN513L, GLU109J, GLU109L, GLU258J, GLU258L, GLU259J, GLU259L, GLU347J, GLU347L, GLU461J, GLU461L, GLU463J, GLU463L, GLU488J, GLU488L, GLU503J, GLU503L, GLU507J, GLU507L, GLU508J, GLU508L, GLY267J, GLY267L, GLY274J, GLY274L, GLY349J, GLY349L, GLY448J, GLY448L, GLY511J, GLY511L, HIS106J, HIS106L, HIS359J, HIS359L, HIS457J, HIS457L, HIS477J, HIS477L, HIS478J, HIS478L, HIS480J, HIS480L, HIS519J, HIS519L, ILE40J, ILE40L, ILE451J, ILE451L, ILE467J, ILE467L, ILE473J, ILE473L, ILE501J, ILE501L, LEU14J, LEU14L, LEU16J, LEU16L, LEU234J, LEU234L, LEU24J, LEU24L, LEU261J, LEU261L, LEU351J, LEU351L, LEU362J, LEU362L, LEU456J, LEU456L, LEU466J, LEU466L, LEU479J, LEU479L, LEU494J, LEU494L, LEU497L, LEU502J, LEU502L, LEU505J, LEU505L, LEU521J, LEU521L, LYS21J, LYS21L, LYS346J, LYS346L, LYS34J, LYS34L, LYS438J, LYS438L, LYS449J, LYS449L, LYS458J, LYS458L, LYS460J, LYS460L, LYS7J, LYS7L, LYS9J, LYS9L, MET354J, MET354L, MET355J, MET355L, MET491J, MET491L, MET512J, MET512L, PHE107J, PHE107L, PHE15J, PHE15L, PHE435J, PHE435L, PHE44J, PHE44L, PHE450J, PHE450L, PHE474J, PHE474L, PRO110J, PRO110L, PRO13J, PRO13L, PRO264J, PRO264L, PRO465J, PRO465L, PRO472J, PRO472L, SER101J, SER101L, SER11J, SER11L, SER358J, SER358L, SER446J, SER446L, SER482J, SER482L, SER500J, SER500L, THR263J, THR263L, THR345J, THR345L, THR356J, THR356L, THR360J, THR360L, THR455J, THR455L, THR47J, THR47L, THR495J, THR495L, THR496J, THR496L, THR509J, THR509L, THR515J, THR515L, TRP361J, TRP361L, TRP428J, TRP428L, TYR102J, TYR102L, TYR12J, TYR12L, TYR20J, TYR20L, TYR35J, TYR35L, TYR447J, TYR447L, TYR517J, TYR517L, VAL260J, VAL260L, VAL352J, VAL352L, VAL464J, VAL464L, VAL498J, VAL498L, VAL522J, VAL522L
• J-M: ALA105M, ALA122J, ALA123J, ALA61M, ALA62M, ALA64M, ARG100M, ASN107M, ASN130J, ASP121J, ASP133J, ASP69M, CYS97M, GLN128J, GLN129J, GLU120J, GLU172J, GLU59M, GLU63M, GLU68M, GLU92M, GLY101M, GLY126J, GLY159J, GLY65M, GLY90M, GLY96M, ILE103M, ILE158J, ILE57M, LEU70M, LYS132J, MET58M, MET60M, PHE108M, PHE125J, PRO91M, THR104M, THR119J, THR56M, THR66M, VAL124J, VAL157J, VAL67M, VAL95M
• J-N: ALA164J, ARG100N, ARG140N, ASN163J, ASN173N, ASP160J, ASP161J, GLU156J, GLY126J, GLY127J, GLY159J, ILE158J, LYS170N, PHE125J, PHE165J, SER174N, TYR171N, VAL124J, VAL157J
• K-L: ALA108K, ALA10L, ALA122L, ALA123L, ALA132K, ALA140L, ALA155L, ALA217K, ALA235K, ALA24K, ALA251K, ALA25L, ALA265L, ALA337K, ALA340K, ALA457K, ALA460K, ALA477K, ALA61L, ALA63K, ALA65K, ALA67L, ALA69L, ALA94K, ALA97L, ARG100L, ARG105L, ARG108L, ARG187K, ARG210K, ARG239K, ARG248K, ARG25K, ARG270L, ARG28K, ARG28L, ARG345K, ARG431L, ARG453L, ARG461K, ARG481L, ARG59L, ARG60K, ARG93K, ARG96K, ARG97K, ASN104L, ASN107K, ASN113K, ASN130L, ASN137L, ASN145K, ASN230K, ASN397L, ASN445L, ASN56L, ASN65L, ASP116L, ASP117K, ASP121L, ASP122K, ASP133L, ASP136K, ASP17L, ASP19L, ASP222K, ASP22L, ASP234K, ASP256K, ASP262L, ASP266L, ASP27K, ASP29L, ASP38L, ASP403K, ASP41L, ASP426L, ASP445K, ASP454K, ASP454L, ASP462K, ASP6L, ASP77K, CYS113L, CYS138L, CYS153L, CYS154K, CYS249K, CYS62K, CYS70L, CYS88K, CYS95L, GLN119K, GLN129L, GLN136L, GLN18L, GLN191K, GLN252K, GLN268L, GLN37L, GLN3L, GLN432K, GLN45L, GLN476K, GLN4L, GLN53K, GLN53L, GLN58L, GLN71L, GLN90K, GLN93L, GLU109L, GLU120K, GLU120L, GLU137K, GLU139K, GLU153K, GLU156L, GLU184K, GLU18K, GLU22K, GLU243K, GLU244K, GLU259L, GLU261K, GLU263K, GLU32L, GLU334K, GLU336K, GLU33L, GLU380K, GLU408K, GLU410K, GLU411K, GLU427K, GLU42L, GLU440K, GLU51L, GLU54L, GLU60L, GLY102K, GLY105K, GLY127K, GLY134L, GLY147K, GLY157K, GLY159L, GLY160K, GLY185K, GLY188K, GLY191L, GLY232K, GLY233K, GLY255K, GLY257K, GLY267L, GLY30L, GLY406K, GLY424K, GLY424L, GLY435K, GLY448K, GLY448L, GLY452K, GLY455K, GLY55K, GLY61K, GLY66K, GLY69K, GLY74L, GLY84K, GLY87K, GLY89K, GLY91L, GLY94L, GLY95K, HIS106L, HIS193L, HIS396L, HIS429L, HIS442K, HIS451K, HIS457L, HIS477L, HIS478L, HIS80K, HIS83K, HIS90L, ILE101K, ILE123K, ILE135K, ILE147L, ILE148K, ILE156K, ILE158L, ILE159K, ILE197K, ILE225K, ILE231K, ILE240K, ILE259K, ILE262K, ILE40L, ILE425K, ILE430K, ILE436K, ILE451L, ILE458K, ILE59K, ILE79K, ILE81K, ILE8L, LEU131K, LEU134K, LEU135L, LEU141K, LEU144K, LEU14L, LEU158K, LEU16L, LEU193K, LEU241K, LEU242K, LEU24L, LEU261L, LEU264K, LEU427L, LEU475K, LEU55L, LEU56K, LEU62L, LEU73L, LYS121K, LYS129K, LYS130K, LYS132L, LYS133K, LYS139L, LYS143L, LYS146K, LYS176K, LYS209K, LYS21L, LYS23K, LYS267K, LYS26L, LYS27L, LYS330K, LYS341K, LYS34L, LYS39L, LYS414K, LYS426K, LYS428K, LYS433K, LYS449L, LYS474K, LYS50K, LYS51K, LYS68K, LYS68L, LYS76K, LYS7L, LYS9L, MET112K, MET118L, MET131L, MET154L, MET23L, MET271L, MET434K, MET57K, MET86L, PHE103L, PHE107L, PHE109K, PHE114K, PHE118K, PHE142K, PHE15L, PHE174L, PHE186K, PHE189L, PHE216K, PHE230L, PHE269L, PHE31L, PHE381K, PHE409K, PHE429K, PHE431K, PHE44L, PHE450L, PHE453K, PHE456K, PHE459K, PHE471L, PHE474L, PHE57L, PHE99L, PRO110L, PRO13L, PRO143K, PRO144L, PRO155K, PRO187L, PRO21K, PRO264L, PRO333K, PRO36L, PRO449K, PRO472L, PRO54K, PRO66L, PRO72L, PRO85K, PRO87L, SER101L, SER112L, SER115L, SER116K, SER117L, SER11L, SER188L, SER190K, SER192K, SER192L, SER218K, SER237K, SER238K, SER254K, SER258K, SER260K, SER2L, SER432L, SER443K, SER446L, SER447K, SER52K, SER67K, SER82K, SER92K, SER92L, THR103K, THR104K, THR111K, THR115K, THR119L, THR140K, THR141L, THR152L, THR215K, THR219K, THR263L, THR265K, THR405K, THR47L, THR48L, THR58K, THR63L, TRP236K, TRP335K, TRP428L, TRP444K, TRP46L, TRP472K, TYR100K, TYR102L, TYR12L, TYR142L, TYR20K, TYR20L, TYR272L, TYR331K, TYR342K, TYR35L, TYR407K, TYR446K, TYR447L, TYR450K, TYR52L, TYR64K, TYR88L, TYR91K, TYR98L, TYR99K, VAL106K, VAL111L, VAL114L, VAL124K, VAL124L, VAL138K, VAL157L, VAL16K, VAL189K, VAL190L, VAL19K, VAL223K, VAL250K, VAL260L, VAL268K, VAL338K, VAL339K, VAL43L, VAL5L, VAL64L, VAL70K, VAL86K, VAL89L, VAL96L
• K-O: ALA172O, ALA201K, ALA64O, ARG100O, ARG140O, ARG182K, ARG187K, ARG203K, ASN107O, ASN142O, ASN173O, ASN49K, ASP162K, ASP200K, ASP204K, ASP27K, ASP69O, GLN53K, GLU110O, GLU111O, GLU112O, GLU141O, GLU164K, GLU184K, GLU68O, GLY113O, GLY157K, GLY160K, GLY175O, GLY188K, GLY65O, HIS31K, ILE103O, ILE163K, ILE197K, ILE47K, LEU158K, LEU193K, LEU70O, LYS168K, LYS170O, LYS23K, LYS26K, LYS30K, LYS43K, LYS50K, LYS51K, MET137O, PHE108O, PHE186K, PRO180K, SER165K, SER174O, SER176O, SER48K, THR66O, TRP205K, TYR171O, VAL166K, VAL169K, VAL169O, VAL189K, VAL67O
• K-P: ALA132K, ALA61P, ALA62P, ALA64P, ARG100P, ARG182K, ARG187K, ASN107P, ASP122K, ASP128K, ASP161K, ASP162K, ASP69P, CYS97P, GLU111P, GLU112P, GLU164K, GLU63P, GLU68P, GLU92P, GLY126K, GLY127K, GLY157K, GLY160K, GLY65P, GLY94P, GLY96P, ILE103P, ILE123K, ILE156K, ILE159K, ILE163K, LEU158K, LEU70P, LYS121K, LYS129K, LYS130K, LYS133K, MET58P, PHE108P, PHE125K, PRO155K, PRO91P, SER165K, THR104P, THR66P, VAL124K, VAL169K, VAL67P, VAL95P
• L-O: ALA122L, ALA123L, ALA98O, ARG100O, ARG140O, ASN107O, ASP121L, CYS97O, GLN129L, GLU120L, GLU92O, GLY101O, GLY126L, GLY134O, GLY65O, GLY90O, GLY94O, GLY96O, GLY99O, ILE103O, MET58O, PHE125L, PRO91O, THR104O, THR119L, VAL124L, VAL67O, VAL95O
• L-P: ALA123L, ARG100P, ARG140P, GLY126L, GLY133P, GLY159L, ILE158L, PHE125L, TYR171P, VAL124L, VAL157L
• M-N: ALA136M, ALA136N, ALA160M, ALA160N, ALA161N, ALA42M, ALA42N, ALA53M, ALA53N, ALA98M, ALA98N, ARG100M, ARG100N, ARG140M, ARG140N, ARG187M, ARG187N, ARG224M, ARG224N, ARG46M, ARG46N, ASN162M, ASN162N, ASN163M, ASN163N, ASP129M, ASP129N, ASP262M, ASP262N, ASP39M, ASP39N, ASP43M, ASP43N, CYS132M, CYS132N, CYS97M, CYS97N, GLN218M, GLN54M, GLN54N, GLU154M, GLU154N, GLU263N, GLU265M, GLU265N, GLU266M, GLU266N, GLU59M, GLU59N, GLU92M, GLU92N, GLY11M, GLY11N, GLY128M, GLY128N, GLY12M, GLY12N, GLY133M, GLY133N, GLY134M, GLY134N, GLY167M, GLY167N, GLY89M, GLY90M, GLY94M, GLY94N, GLY96M, GLY96N, GLY99M, GLY99N, ILE139M, ILE139N, ILE13M, ILE164M, ILE164N, ILE168M, ILE168N, ILE222M, ILE222N, ILE273N, LEU127M, LEU127N, LEU264N, LEU268M, LEU268N, LYS10M, LYS10N, LYS166M, LYS166N, LYS170M, LYS170N, LYS41M, LYS41N, LYS52M, LYS52N, MET137N, MET155M, MET155N, MET156M, MET156N, MET261M, MET261N, MET269M, MET269N, PHE135M, PHE135N, PRO258M, PRO258N, PRO40M, PRO40N, PRO91M, PRO91N, PRO93M, PRO93N, SER165M, SER165N, THR56M, TYR159M, TYR159N, TYR171M, TYR171N, TYR8N, VAL130M, VAL130N, VAL131M, VAL131N, VAL169M, VAL169N, VAL95M, VAL95N
• O-P: ALA136O, ALA136P, ALA157P, ALA160O, ALA160P, ALA42O, ALA42P, ALA53O, ALA53P, ALA98O, ALA98P, ARG100O, ARG100P, ARG140O, ARG140P, ARG187O, ARG187P, ARG213O, ARG213P, ARG224O, ARG224P, ARG46O, ARG46P, ASN162O, ASN162P, ASN163O, ASN163P, ASP129O, ASP129P, ASP262O, ASP262P, ASP39O, ASP39P, ASP43O, ASP43P, CYS132O, CYS132P, CYS97O, CYS97P, GLU154O, GLU154P, GLU265P, GLU266P, GLU92O, GLU92P, GLY11O, GLY11P, GLY128O, GLY128P, GLY12O, GLY12P, GLY133O, GLY133P, GLY134O, GLY134P, GLY14O, GLY14P, GLY167O, GLY167P, GLY94O, GLY94P, GLY96O, GLY96P, GLY99O, GLY99P, ILE139O, ILE139P, ILE13O, ILE13P, ILE164O, ILE164P, ILE168O, ILE168P, ILE222O, LEU127O, LEU127P, LEU264P, LYS10O, LYS10P, LYS15O, LYS15P, LYS166O, LYS166P, LYS170O, LYS170P, LYS41O, LYS41P, LYS52O, LYS52P, MET137O, MET137P, MET155O, MET155P, MET156O, MET156P, MET261O, MET261P, MET269P, PHE135O, PHE135P, PRO258O, PRO258P, PRO40O, PRO40P, PRO91O, PRO91P, PRO93O, PRO93P, SER165O, SER165P, SER16P, TYR159O, TYR159P, TYR171O, TYR171P, VAL130O, VAL130P, VAL131O, VAL131P, VAL169O, VAL169P, VAL95O, VAL95P