2AF6

crystal structure of mycobacterium tuberculosis flavin dependent thymidylate synthase (mtb thyx) in the presence of co-factor fad and substrate analog 5-bromo-2'-deoxyuridine-5'-monophosphate (brdump)

• Total interactions analyzed: 28
• Total true interactions: 15
• Strongest Interaction:
  • Chains: F-H
  • Int. Res.: 152
  • Norm. En. per Res.: -4.283
• Hub Node: B(4)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-16.4315	10.7247	-11.4508	-17.1576	30	4	0	1037	8	13	33
A-C	-135.9418	-61.6243	-440.135	-637.7011	153	26	26	17403	4	18	25
A-D	-88.7823	-101.8234	-480.303	-670.9087	195	20	18	20408	7	74	85
B-C	-63.1014	-103.8083	-459.977	-626.8866	192	19	18	19856	10	74	85
B-D	-116.4448	-57.102	-453.532	-627.0788	151	20	26	17599	5	18	23
B-F	-11.8075	11.57	-96.9538	-97.1913	58	3	2	4386	0	10	6
B-H	-23.5574	-17.6426	-30.2076	-71.4076	45	2	0	1455	3	12	15
C-D	-17.8599	10.6402	-16.0243	-23.244	30	4	0	1042	8	12	34
D-H	-11.0841	-25.1964	-17.893	-54.1735	26	0	0	944	4	9	10
E-F	-14.5767	10.5171	-12.5144	-16.574	30	4	0	1047	8	11	31
E-G	-119.8801	-42.6365	-445.732	-608.2486	154	18	26	17375	3	18	24
E-H	-62.8742	-93.6373	-451.214	-607.7256	191	19	19	19848	8	74	84
F-G	-103.3535	-107.186	-482.331	-692.8704	192	19	18	20041	8	74	84
F-H	-125.4066	-59.6439	-465.959	-651.0094	152	25	27	18002	4	18	24
G-H	-16.3311	10.7451	-9.4175	-15.0036	30	4	0	1064	8	12	33

Interface residues

• A-B: ALA247A, ALA247B, ARG190A, ARG190B, ARG95A, ARG95B, ARG97A, ARG97B, ASN188A, ASN188B, CYS43A, CYS43B, GLU74A, GLU74B, HIS194A, HIS194B, HIS203A, HIS203B, HIS75A, HIS75B, HIS98A, HIS98B, PHE70A, PHE70B, SER71A, SER71B, VAL67A, VAL67B, VAL72A, VAL72B
• A-C: ALA13A, ALA13C, ALA19A, ALA19C, ALA34A, ALA34C, ALA39A, ALA39C, ALA42A, ALA42C, ALA76A, ALA76C, ARG107A, ARG107C, ARG115A, ARG115C, ARG164A, ARG168C, ARG182A, ARG182C, ARG190A, ARG190C, ARG41A, ARG41C, ARG8A, ARG8C, ARG97A, ARG97C, ASN188A, ASN188C, ASP16A, ASP16C, ASP22A, ASP22C, CYS43A, CYS43C, GLN103A, GLN103C, GLN106A, GLN106C, GLN10A, GLN10C, GLN45A, GLN45C, GLU111C, GLU180A, GLU180C, GLU37A, GLU37C, GLU74A, GLU74C, GLY187A, GLY187C, GLY31A, GLY31C, GLY32A, GLY32C, GLY40A, GLY40C, HIS63C, HIS69A, HIS75A, HIS75C, HIS98A, HIS98C, ILE12A, ILE12C, ILE161A, ILE161C, ILE183A, ILE183C, ILE82A, ILE82C, LEU104A, LEU104C, LEU11A, LEU11C, LEU18A, LEU18C, LEU35A, LEU35C, LEU73A, LEU73C, LYS14A, LYS14C, LYS165A, LYS165C, PHE17A, PHE17C, PHE38A, PHE38C, PHE80A, PHE80C, PHE99A, PHE99C, PRO110A, PRO110C, PRO20A, PRO20C, PRO21A, PRO21C, PRO24A, PRO24C, SER100A, SER100C, SER102A, SER102C, SER105A, SER105C, SER46A, SER46C, SER71A, SER71C, SER77A, SER77C, SER79A, SER79C, THR15A, THR15C, THR181C, THR186A, THR186C, THR83A, THR83C, TRP25A, TRP25C, TRP47A, TRP47C, TYR101A, TYR101C, TYR108A, TYR108C, TYR44A, TYR44C, TYR81A, TYR81C, VAL109A, VAL109C, VAL184A, VAL184C, VAL185A, VAL185C, VAL23A, VAL23C, VAL36A, VAL36C, VAL67A, VAL67C, VAL72A, VAL72C, VAL78A, VAL78C, VAL9A
• A-D: ALA126A, ALA126D, ALA135A, ALA135D, ALA136A, ALA136D, ALA138A, ALA138D, ALA139A, ALA139D, ALA141A, ALA141D, ALA148A, ALA148D, ALA152A, ALA152D, ALA167A, ALA167D, ALA170A, ALA170D, ALA171A, ALA171D, ALA173A, ALA173D, ALA178A, ALA178D, ALA204A, ALA204D, ALA236A, ALA236D, ARG107A, ARG107D, ARG129A, ARG129D, ARG168A, ARG168D, ARG172A, ARG172D, ARG199A, ARG199D, ARG209A, ARG209D, ARG87A, ARG87D, ARG95A, ARG95D, ARG97A, ARG97D, ASN159A, ASN177A, ASN177D, ASP124A, ASP124D, ASP125A, ASP125D, ASP127A, ASP127D, ASP156A, ASP156D, ASP205A, ASP205D, ASP237A, ASP237D, CYS89A, CYS89D, GLN103A, GLN103D, GLN106A, GLN106D, GLN157A, GLN157D, GLN166A, GLN166D, GLN169A, GLN169D, GLU111A, GLU111D, GLU123A, GLU123D, GLU134A, GLU134D, GLU145A, GLU145D, GLU151A, GLU151D, GLU202A, GLU202D, GLU207A, GLU207D, GLU92A, GLU92D, GLY121A, GLY121D, GLY238D, HIS130A, HIS130D, HIS203A, HIS203D, HIS91A, HIS91D, HIS96A, HIS96D, HIS98A, HIS98D, ILE131A, ILE131D, ILE183A, ILE183D, ILE208A, ILE208D, ILE85A, ILE85D, ILE94A, ILE94D, LEU104A, LEU104D, LEU128A, LEU128D, LEU132A, LEU132D, LEU146A, LEU146D, LEU147A, LEU147D, LEU150A, LEU150D, LEU162A, LEU162D, LEU235A, LEU235D, LEU93A, LEU93D, LYS149A, LYS149D, LYS153A, LYS153D, LYS165A, LYS165D, PHE154A, PHE154D, PHE99A, PHE99D, PRO119A, PRO119D, PRO120A, PRO120D, PRO158A, PRO176A, PRO176D, SER100A, SER100D, SER102A, SER102D, SER105A, SER105D, SER144A, SER144D, SER201A, SER201D, SER86A, SER86D, SER88A, SER88D, THR133A, THR133D, THR142A, THR142D, THR179A, THR179D, THR181A, THR181D, THR186A, THR186D, THR239A, THR239D, THR90A, THR90D, TYR101A, TYR101D, TYR108D, TYR143A, TYR143D, VAL116A, VAL116D, VAL117A, VAL117D, VAL118A, VAL118D, VAL174A, VAL174D, VAL184A, VAL184D, VAL185A, VAL206A, VAL206D
• B-C: ALA126B, ALA126C, ALA135B, ALA135C, ALA136B, ALA136C, ALA138B, ALA138C, ALA139B, ALA139C, ALA141B, ALA141C, ALA148B, ALA148C, ALA152B, ALA152C, ALA167B, ALA167C, ALA170B, ALA170C, ALA171B, ALA171C, ALA173B, ALA173C, ALA178B, ALA178C, ALA204B, ALA204C, ALA236B, ALA236C, ARG107B, ARG107C, ARG129B, ARG129C, ARG168B, ARG168C, ARG172B, ARG172C, ARG199B, ARG199C, ARG209B, ARG209C, ARG87B, ARG87C, ARG95B, ARG95C, ARG97B, ARG97C, ASN177B, ASN177C, ASP124B, ASP124C, ASP125B, ASP125C, ASP127B, ASP127C, ASP156B, ASP156C, ASP205B, ASP205C, ASP237B, ASP237C, CYS89B, CYS89C, GLN103B, GLN103C, GLN106B, GLN106C, GLN157B, GLN157C, GLN166B, GLN166C, GLN169B, GLN169C, GLU111B, GLU111C, GLU123B, GLU123C, GLU134B, GLU134C, GLU145B, GLU145C, GLU151B, GLU151C, GLU202B, GLU202C, GLU207B, GLU207C, GLU92B, GLU92C, GLY121B, GLY121C, HIS130B, HIS130C, HIS203B, HIS203C, HIS91B, HIS91C, HIS96B, HIS96C, HIS98B, HIS98C, ILE131B, ILE131C, ILE183B, ILE183C, ILE208B, ILE208C, ILE85B, ILE85C, ILE94B, ILE94C, LEU104B, LEU104C, LEU128B, LEU128C, LEU132B, LEU132C, LEU146B, LEU146C, LEU147B, LEU147C, LEU150B, LEU150C, LEU162B, LEU162C, LEU235B, LEU235C, LEU93B, LEU93C, LYS149B, LYS149C, LYS153B, LYS153C, LYS165B, LYS165C, PHE154B, PHE154C, PHE99B, PHE99C, PRO119B, PRO119C, PRO120B, PRO120C, PRO158B, PRO176B, PRO176C, SER100B, SER100C, SER102B, SER102C, SER105B, SER105C, SER201B, SER201C, SER86B, SER86C, SER88B, SER88C, THR133B, THR133C, THR142B, THR142C, THR179B, THR179C, THR181B, THR181C, THR186B, THR186C, THR239B, THR239C, THR90B, THR90C, TYR101B, TYR101C, TYR108B, TYR108C, TYR143B, TYR143C, VAL116B, VAL116C, VAL117B, VAL117C, VAL118B, VAL118C, VAL174B, VAL174C, VAL184B, VAL184C, VAL185B, VAL206B, VAL206C
• B-D: ALA13B, ALA13D, ALA19B, ALA19D, ALA34B, ALA34D, ALA39B, ALA39D, ALA42B, ALA42D, ALA76B, ALA76D, ARG107B, ARG107D, ARG168B, ARG168D, ARG182B, ARG182D, ARG190B, ARG190D, ARG41B, ARG41D, ARG8B, ARG8D, ARG97B, ARG97D, ASN188B, ASN188D, ASP16B, ASP16D, ASP22B, ASP22D, CYS43B, CYS43D, GLN103B, GLN103D, GLN106B, GLN106D, GLN10B, GLN10D, GLN45B, GLN45D, GLU111D, GLU180B, GLU180D, GLU37B, GLU37D, GLU74B, GLU74D, GLY187B, GLY187D, GLY31B, GLY31D, GLY32B, GLY32D, GLY40B, GLY40D, HIS69B, HIS69D, HIS75B, HIS75D, HIS98B, HIS98D, ILE12B, ILE12D, ILE161D, ILE183B, ILE183D, ILE82B, ILE82D, LEU104B, LEU104D, LEU11B, LEU11D, LEU18B, LEU18D, LEU35B, LEU35D, LEU73B, LEU73D, LYS14B, LYS14D, LYS165B, LYS165D, PHE17B, PHE17D, PHE38B, PHE38D, PHE80B, PHE80D, PHE99B, PHE99D, PRO110B, PRO110D, PRO20B, PRO20D, PRO21B, PRO21D, PRO24B, PRO24D, SER100B, SER100D, SER102B, SER102D, SER105B, SER105D, SER46B, SER46D, SER71B, SER71D, SER77B, SER77D, SER79B, SER79D, THR15B, THR15D, THR181B, THR181D, THR186B, THR186D, THR83B, THR83D, TRP25B, TRP25D, TRP47B, TRP47D, TYR101B, TYR101D, TYR108B, TYR108D, TYR44B, TYR44D, TYR81B, TYR81D, VAL109B, VAL109D, VAL184B, VAL184D, VAL185B, VAL185D, VAL23B, VAL23D, VAL36B, VAL36D, VAL67D, VAL72B, VAL72D, VAL78B, VAL78D, VAL9B, VAL9D
• B-F: ALA19F, ALA220B, ALA221B, ALA223B, ALA225B, ALA228B, ALA29B, ALA55B, ALA55F, ALA58B, ARG217B, ARG41F, ARG62B, ASN51F, ASN57B, ASP22F, ASP28B, GLN218B, GLN45F, GLU214B, GLU231B, GLU240B, GLY59B, ILE213B, LEU216B, LEU219B, LEU235B, LEU61B, LYS49F, LYS53B, LYS53F, PHE227B, PHE230B, PRO20F, PRO21F, PRO224B, PRO24F, PRO33B, PRO50F, PRO52B, PRO52F, SER46F, SER48F, THR233B, THR234B, THR239B, THR26F, THR54B, THR56B, THR56F, TRP25F, TRP47F, TYR60B, VAL222B, VAL226B, VAL232B, VAL23F, VAL241B
• B-H: ALA160H, ALA19B, ALA221B, ALA29B, ALA34B, ALA55B, ALA5H, ARG115H, ARG140H, ARG163H, ARG164H, ARG182H, ARG8B, ARG8H, ASN57B, ASP113H, ASP16B, ASP28B, ASP30B, GLN10B, GLN10H, GLN218B, GLU151H, GLU180H, GLU214B, GLU3H, GLY31B, LEU11B, LEU18B, LYS112H, LYS14B, PHE17B, PRO110H, PRO52B, PRO6H, SER114H, THR15B, THR26B, THR27B, THR4H, THR56B, THR83H, TRP25B, VAL222B, VAL9B
• C-D: ARG190C, ARG190D, ARG95C, ARG95D, ARG97C, ARG97D, ASN188C, ASN188D, CYS43C, CYS43D, GLU74C, GLU74D, HIS194C, HIS194D, HIS203C, HIS203D, HIS69D, HIS75C, HIS75D, HIS96D, HIS98C, HIS98D, PHE70C, PHE70D, SER71C, SER71D, VAL67C, VAL67D, VAL72C, VAL72D
• D-H: ALA148H, ALA152H, ALA155H, ALA160H, ALA19D, ARG163H, ARG164H, ARG168H, ASP113H, ASP16D, ASP22D, GLU151H, LEU147H, LEU150H, LEU18D, LYS112H, LYS149H, PHE17D, PRO110H, PRO20D, PRO21D, PRO24D, SER144H, THR26D, TYR143H, VAL23D
• E-F: ARG190E, ARG190F, ARG95E, ARG95F, ARG97E, ARG97F, ASN188E, ASN188F, CYS43E, CYS43F, GLU74E, GLU74F, HIS194E, HIS194F, HIS203E, HIS203F, HIS69F, HIS75E, HIS75F, HIS96F, HIS98E, HIS98F, PHE70E, PHE70F, SER71E, SER71F, VAL67E, VAL67F, VAL72E, VAL72F
• E-G: ALA13E, ALA13G, ALA19E, ALA19G, ALA34E, ALA34G, ALA39E, ALA39G, ALA42E, ALA42G, ALA76E, ALA76G, ARG107E, ARG107G, ARG115E, ARG115G, ARG168E, ARG168G, ARG182E, ARG182G, ARG190E, ARG190G, ARG41E, ARG41G, ARG8E, ARG8G, ARG97E, ARG97G, ASN188E, ASN188G, ASP16E, ASP16G, ASP22E, ASP22G, CYS43E, CYS43G, GLN103E, GLN103G, GLN106E, GLN106G, GLN10E, GLN10G, GLN45E, GLN45G, GLU111E, GLU180E, GLU180G, GLU37E, GLU37G, GLU74E, GLU74G, GLY187E, GLY187G, GLY31E, GLY31G, GLY32E, GLY32G, GLY40E, GLY40G, HIS69E, HIS69G, HIS75E, HIS75G, HIS98E, HIS98G, ILE12E, ILE12G, ILE161E, ILE161G, ILE183E, ILE183G, ILE64E, ILE82E, ILE82G, LEU104E, LEU104G, LEU11E, LEU11G, LEU18E, LEU18G, LEU35E, LEU35G, LEU73E, LEU73G, LYS14E, LYS14G, LYS165E, LYS165G, PHE17E, PHE17G, PHE38E, PHE38G, PHE80E, PHE80G, PHE99E, PHE99G, PRO110E, PRO110G, PRO20E, PRO20G, PRO21E, PRO21G, PRO24E, PRO24G, SER100E, SER100G, SER102E, SER102G, SER105E, SER105G, SER46E, SER46G, SER71E, SER71G, SER77E, SER77G, SER79E, SER79G, THR15E, THR15G, THR181E, THR181G, THR186E, THR186G, THR83E, THR83G, TRP25E, TRP25G, TRP47E, TRP47G, TYR101E, TYR101G, TYR108E, TYR108G, TYR44E, TYR44G, TYR81E, TYR81G, VAL109E, VAL109G, VAL184E, VAL184G, VAL185E, VAL185G, VAL23E, VAL23G, VAL36E, VAL36G, VAL67E, VAL67G, VAL72E, VAL72G, VAL78E, VAL78G
• E-H: ALA126E, ALA126H, ALA135E, ALA135H, ALA136E, ALA136H, ALA138E, ALA138H, ALA139E, ALA139H, ALA141E, ALA141H, ALA148E, ALA148H, ALA152E, ALA152H, ALA167E, ALA167H, ALA170E, ALA170H, ALA171E, ALA171H, ALA173E, ALA173H, ALA178E, ALA178H, ALA204E, ALA204H, ALA236E, ALA236H, ARG107E, ARG107H, ARG129E, ARG129H, ARG168E, ARG168H, ARG172E, ARG172H, ARG199E, ARG199H, ARG209E, ARG209H, ARG87E, ARG87H, ARG95E, ARG95H, ARG97E, ARG97H, ASN177E, ASN177H, ASP124E, ASP124H, ASP125E, ASP125H, ASP127E, ASP127H, ASP156E, ASP156H, ASP205E, ASP205H, ASP237E, ASP237H, CYS89E, CYS89H, GLN103E, GLN103H, GLN106E, GLN106H, GLN157E, GLN157H, GLN166E, GLN166H, GLN169E, GLN169H, GLU111E, GLU111H, GLU123E, GLU123H, GLU134E, GLU134H, GLU145E, GLU145H, GLU151E, GLU151H, GLU202E, GLU202H, GLU207E, GLU207H, GLU92E, GLU92H, GLY121E, GLY121H, HIS130E, HIS130H, HIS203E, HIS203H, HIS91E, HIS91H, HIS96E, HIS96H, HIS98E, HIS98H, ILE131E, ILE131H, ILE183E, ILE183H, ILE208E, ILE208H, ILE85E, ILE85H, ILE94E, ILE94H, LEU104E, LEU104H, LEU128E, LEU128H, LEU132E, LEU132H, LEU146E, LEU146H, LEU147E, LEU147H, LEU150E, LEU150H, LEU162E, LEU162H, LEU235E, LEU235H, LEU93E, LEU93H, LYS149E, LYS149H, LYS153E, LYS153H, LYS165E, LYS165H, PHE154E, PHE154H, PHE99E, PHE99H, PRO119E, PRO119H, PRO120E, PRO120H, PRO176E, PRO176H, SER100E, SER100H, SER102E, SER102H, SER105E, SER105H, SER201E, SER201H, SER86E, SER86H, SER88E, SER88H, THR133E, THR133H, THR142E, THR142H, THR179E, THR179H, THR181E, THR181H, THR186E, THR186H, THR239E, THR239H, THR90E, THR90H, TYR101E, TYR101H, TYR108E, TYR108H, TYR143E, TYR143H, VAL116E, VAL116H, VAL117E, VAL117H, VAL118E, VAL118H, VAL174E, VAL174H, VAL184E, VAL184H, VAL185H, VAL206E, VAL206H
• F-G: ALA126F, ALA126G, ALA135F, ALA135G, ALA136F, ALA136G, ALA138F, ALA138G, ALA139F, ALA139G, ALA141F, ALA141G, ALA148F, ALA148G, ALA152F, ALA152G, ALA167F, ALA167G, ALA170F, ALA170G, ALA171F, ALA171G, ALA173F, ALA173G, ALA178F, ALA178G, ALA204F, ALA204G, ALA236F, ALA236G, ARG107F, ARG107G, ARG129F, ARG129G, ARG168F, ARG168G, ARG172F, ARG172G, ARG199F, ARG199G, ARG209F, ARG209G, ARG87F, ARG87G, ARG95F, ARG95G, ARG97F, ARG97G, ASN177F, ASN177G, ASP124F, ASP124G, ASP125F, ASP125G, ASP127F, ASP127G, ASP156F, ASP156G, ASP205F, ASP205G, ASP237F, ASP237G, CYS89F, CYS89G, GLN103F, GLN103G, GLN106F, GLN106G, GLN157F, GLN157G, GLN166F, GLN166G, GLN169F, GLN169G, GLU111F, GLU111G, GLU123F, GLU123G, GLU134F, GLU134G, GLU145F, GLU145G, GLU151F, GLU151G, GLU202F, GLU202G, GLU207F, GLU207G, GLU92F, GLU92G, GLY121F, GLY121G, HIS130F, HIS130G, HIS203F, HIS203G, HIS91F, HIS91G, HIS96F, HIS96G, HIS98F, HIS98G, ILE131F, ILE131G, ILE183F, ILE183G, ILE208F, ILE208G, ILE85F, ILE85G, ILE94F, ILE94G, LEU104F, LEU104G, LEU128F, LEU128G, LEU132F, LEU132G, LEU146F, LEU146G, LEU147F, LEU147G, LEU150F, LEU150G, LEU162F, LEU162G, LEU235F, LEU235G, LEU93F, LEU93G, LYS149F, LYS149G, LYS153F, LYS153G, LYS165F, LYS165G, PHE154F, PHE154G, PHE99F, PHE99G, PRO119F, PRO119G, PRO120F, PRO120G, PRO176F, PRO176G, SER100F, SER100G, SER102F, SER102G, SER105F, SER105G, SER201F, SER201G, SER86F, SER86G, SER88F, SER88G, THR133F, THR133G, THR142F, THR142G, THR179F, THR179G, THR181F, THR181G, THR186F, THR186G, THR239F, THR239G, THR90F, THR90G, TYR101F, TYR101G, TYR108F, TYR108G, TYR143F, TYR143G, VAL116F, VAL116G, VAL117F, VAL117G, VAL118F, VAL118G, VAL174F, VAL174G, VAL184F, VAL184G, VAL185F, VAL185G, VAL206F, VAL206G
• F-H: ALA13F, ALA13H, ALA19F, ALA19H, ALA34F, ALA34H, ALA39F, ALA39H, ALA42F, ALA42H, ALA76F, ALA76H, ARG107F, ARG107H, ARG168F, ARG182F, ARG182H, ARG190F, ARG190H, ARG41F, ARG41H, ARG8F, ARG8H, ARG97F, ARG97H, ASN188F, ASN188H, ASP16F, ASP16H, ASP22F, ASP22H, CYS43F, CYS43H, GLN103F, GLN103H, GLN106F, GLN106H, GLN10F, GLN10H, GLN45F, GLN45H, GLU111H, GLU180F, GLU180H, GLU37H, GLU74F, GLU74H, GLY187F, GLY187H, GLY31F, GLY31H, GLY32F, GLY32H, GLY40F, GLY40H, HIS69F, HIS69H, HIS75F, HIS75H, HIS98F, HIS98H, ILE12F, ILE12H, ILE161F, ILE161H, ILE183F, ILE183H, ILE82F, ILE82H, LEU104F, LEU104H, LEU11F, LEU11H, LEU18F, LEU18H, LEU35F, LEU35H, LEU73F, LEU73H, LYS14F, LYS14H, LYS165F, LYS165H, PHE17F, PHE17H, PHE38F, PHE38H, PHE80F, PHE80H, PHE99F, PHE99H, PRO110F, PRO110H, PRO20F, PRO20H, PRO21F, PRO21H, PRO24F, PRO24H, SER100F, SER100H, SER102F, SER102H, SER105F, SER105H, SER46F, SER46H, SER71F, SER71H, SER77F, SER77H, SER79F, SER79H, THR15F, THR15H, THR181F, THR181H, THR186F, THR186H, THR83F, THR83H, TRP25F, TRP25H, TRP47F, TRP47H, TYR101F, TYR101H, TYR108F, TYR108H, TYR44F, TYR44H, TYR81F, TYR81H, VAL109F, VAL109H, VAL184F, VAL184H, VAL185F, VAL185H, VAL222F, VAL23F, VAL23H, VAL36F, VAL36H, VAL67F, VAL67H, VAL72F, VAL72H, VAL78F, VAL78H, VAL9F, VAL9H
• G-H: ARG190G, ARG190H, ARG95G, ARG95H, ARG97G, ARG97H, ASN188G, ASN188H, CYS43G, CYS43H, GLU74G, GLU74H, HIS194G, HIS194H, HIS203G, HIS203H, HIS69G, HIS75G, HIS75H, HIS98G, HIS98H, PHE70G, PHE70H, SER71G, SER71H, THR248G, VAL67G, VAL67H, VAL72G, VAL72H