2A8Y

crystal structure of 5'-deoxy-5'methylthioadenosine phosphorylase complexed with 5'-deoxy- 5'methylthioadenosine and sulfate

• Total interactions analyzed: 66
• Total true interactions: 24
• Strongest Interaction:
  • Chains: J-K
  • Int. Res.: 109
  • Norm. En. per Res.: -4.8903
• Hub Node: A(4)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-89.7579	-66.3863	-343.666	-499.8102	111	22	8	13871	5	45	39
A-C	-86.4328	-64.5283	-337.291	-488.2521	112	14	7	13925	5	45	39
A-J	-37.6997	-28.6686	-70.6811	-137.0494	37	2	0	2921	0	14	20
A-K	-2.5268	0.0	-275.944	-278.4708	92	5	5	10893	0	10	6
B-C	-83.2055	-58.8075	-346.314	-488.327	110	14	7	14079	4	45	39
B-J	-10.8859	0.0	-297.832	-308.7179	91	6	5	10783	0	10	6
B-L	-37.3394	-8.5193	-72.6265	-118.4852	38	2	0	2751	0	13	20
C-K	-37.3759	-8.6254	-68.8225	-114.8238	37	2	0	2697	0	14	20
C-L	-2.3068	0.0	-290.543	-292.8498	92	10	5	11013	0	10	7
D-E	-77.0042	-65.8132	-347.844	-490.6614	110	23	7	14191	5	45	39
D-F	-94.7923	-60.4815	-363.532	-518.8058	112	22	7	14444	4	45	39
D-G	-24.2369	-9.802	-61.3051	-95.344	39	1	0	2544	0	14	20
D-H	-2.5165	0.0	-275.391	-277.9075	94	8	5	10825	0	10	6
E-F	-89.3525	-63.4691	-360.755	-513.5766	110	15	8	14176	5	45	38
E-G	-10.1141	0.0	-276.026	-286.1401	92	8	5	10873	0	10	6
E-I	-28.8027	-8.4765	-72.8879	-110.1671	38	1	0	2738	0	13	20
F-H	-37.9353	-8.6035	-71.0215	-117.5604	40	2	0	2693	0	14	20
F-I	0.0	0.0	-273.249	-273.249	91	4	4	10761	0	10	6
G-H	-99.7951	-62.6263	-354.246	-516.6674	110	16	7	14080	5	44	39
G-I	-96.3859	-64.8624	-355.757	-517.0052	108	18	8	13835	4	45	38
H-I	-89.1305	-61.2671	-357.682	-508.0796	111	22	7	14371	5	45	39
J-K	-113.1222	-60.9808	-358.938	-533.041	109	19	7	14193	4	44	39
J-L	-88.2386	-56.3768	-356.023	-500.6384	111	25	7	14456	4	45	39
K-L	-77.8333	-68.5458	-349.754	-496.1331	110	26	8	14107	5	44	39

Interface residues

• A-B: ALA129B, ALA134B, ALA174A, ALA185B, ALA225A, ALA268B, ARG118A, ARG118B, ARG169A, ARG173A, ARG177A, ARG61A, ARG64A, ARG73B, ASN117A, ASN117B, ASN197B, ASP109B, ASP113B, ASP124B, ASP135B, ASP216A, CYS164B, CYS200B, GLN110B, GLU119B, GLU166A, GLU166B, GLU175A, GLU181A, GLU181B, GLU201B, GLU226A, GLU227A, GLY125B, GLY160B, GLY167A, GLY17A, GLY62A, HIS130B, HIS59A, HIS63A, HIS68A, ILE112B, ILE163B, ILE165A, ILE165B, ILE221A, ILE65A, ILE70A, LEU192B, LEU198B, LEU265B, LEU269B, LYS116A, LYS116B, LYS184A, LYS184B, LYS266B, LYS69A, MET114A, MET114B, MET133B, MET190A, PHE111B, PHE122B, PHE123B, PHE137B, PHE170A, PHE218A, PRO126B, PRO136B, PRO168A, PRO194B, PRO222A, PRO66A, PRO67A, SER121B, SER132B, SER16A, SER171A, SER176A, SER264B, THR115A, THR115B, THR161B, THR172A, THR178A, THR178B, THR191A, THR224A, THR229A, THR267B, TRP179A, TRP179B, TYR120A, TYR120B, TYR162B, TYR183A, TYR183B, VAL127B, VAL128B, VAL131B, VAL182A, VAL182B, VAL193B, VAL196B, VAL217A, VAL223A, VAL228A, VAL270B
• A-C: ALA129A, ALA134A, ALA174C, ALA185A, ALA225C, ALA268A, ARG118A, ARG118C, ARG169C, ARG173C, ARG177C, ARG180A, ARG61C, ARG64C, ARG73A, ASN117A, ASN117C, ASN197A, ASP109A, ASP113A, ASP124A, ASP135A, ASP216C, CYS164A, CYS200A, GLN110A, GLU119A, GLU166A, GLU166C, GLU175C, GLU181A, GLU181C, GLU201A, GLU226C, GLU227C, GLY125A, GLY160A, GLY167C, GLY17C, GLY62C, HIS130A, HIS59C, HIS63C, HIS68C, ILE112A, ILE112C, ILE163A, ILE163C, ILE165A, ILE165C, ILE221C, ILE65C, ILE70C, LEU192A, LEU198A, LEU265A, LEU269A, LYS116A, LYS116C, LYS184A, LYS266A, LYS69C, MET114A, MET114C, MET133A, MET190C, PHE111A, PHE122A, PHE123A, PHE137A, PHE170C, PHE218C, PRO126A, PRO136A, PRO168C, PRO194A, PRO222C, PRO66C, PRO67C, SER121A, SER132A, SER16C, SER171C, SER176C, THR115A, THR115C, THR161A, THR172C, THR178A, THR178C, THR191C, THR224C, THR229C, THR267A, TRP179A, TRP179C, TYR120A, TYR120C, TYR162A, TYR183A, TYR183C, VAL127A, VAL128A, VAL131A, VAL182A, VAL182C, VAL193A, VAL196A, VAL217C, VAL223C, VAL228C, VAL270A
• A-J: ARG61A, ARG61J, ARG64A, ARG64J, ASP41A, ASP41J, GLN38A, GLN38J, GLU29A, GLU29J, GLY37A, GLY37J, GLY60A, GLY60J, GLY62A, GLY62J, HIS59A, HIS59J, HIS63A, HIS63J, ILE65A, ILE65J, ILE70A, ILE70J, LYS31A, LYS31J, LYS69A, LYS69J, PHE42A, PHE42J, PRO39A, PRO39J, PRO66A, PRO66J, SER40A, SER40J, TYR19A
• A-K: ALA129A, ALA129K, ALA199A, ALA199K, ALA202A, ALA202K, ALA74A, ALA74K, ALA78A, ALA78K, ARG64A, ARG64K, ARG73A, ARG73K, ASN71A, ASN71K, ASP124A, ASP124K, ASP41A, ASP41K, GLN203A, GLN203K, GLN38A, GLN38K, GLN4A, GLN4K, GLU201A, GLU201K, GLU3A, GLU3K, GLU81A, GLU81K, GLY125A, GLY125K, GLY37A, GLY37K, ILE2A, ILE2K, ILE30A, ILE30K, ILE43A, ILE43K, ILE76A, ILE76K, LEU198A, LEU198K, LEU265A, LEU265K, LEU269A, LEU269K, LEU79A, LEU79K, LYS266K, LYS31A, LYS31K, LYS80A, LYS80K, MET1A, MET1K, MET204A, MET204K, PHE122A, PHE122K, PHE123A, PHE123K, PHE42A, PHE42K, PRO126A, PRO126K, PRO35A, PRO35K, PRO39A, PRO39K, SER121A, SER121K, SER40A, THR34A, THR34K, TRP77A, TRP77K, TYR33A, TYR33K, TYR36A, TYR36K, VAL127A, VAL127K, VAL128A, VAL128K, VAL270A, VAL270K, VAL32A, VAL32K
• B-C: ALA129C, ALA134C, ALA174B, ALA185C, ALA225B, ALA268C, ARG118B, ARG118C, ARG169B, ARG173B, ARG177B, ARG230B, ARG61B, ARG64B, ARG73C, ASN117B, ASN117C, ASN197C, ASP109C, ASP113C, ASP124C, ASP135C, ASP216B, CYS164C, CYS200C, GLN110C, GLU119C, GLU166B, GLU166C, GLU175B, GLU181B, GLU181C, GLU201C, GLU226B, GLU227B, GLY125C, GLY160C, GLY167B, GLY17B, GLY62B, HIS130C, HIS59B, HIS63B, HIS68B, ILE112C, ILE163B, ILE163C, ILE165B, ILE165C, ILE221B, ILE65B, ILE70B, LEU192C, LEU198C, LEU265C, LEU269C, LYS116B, LYS116C, LYS184C, LYS266C, LYS69B, MET114B, MET114C, MET133C, MET190B, PHE111C, PHE122C, PHE123C, PHE137C, PHE170B, PHE218B, PRO126C, PRO136C, PRO168B, PRO194C, PRO222B, PRO66B, PRO67B, SER121C, SER132C, SER16B, SER171B, SER176B, THR115B, THR115C, THR161C, THR172B, THR178B, THR178C, THR191B, THR224B, THR229B, THR267C, TRP179B, TRP179C, TYR120C, TYR162C, TYR183B, TYR183C, VAL127C, VAL128C, VAL131C, VAL182B, VAL182C, VAL193C, VAL196C, VAL217B, VAL223B, VAL228B, VAL270C
• B-J: ALA129B, ALA129J, ALA199B, ALA199J, ALA202B, ALA202J, ALA74B, ALA74J, ALA78B, ALA78J, ARG64B, ARG64J, ARG73B, ARG73J, ASN71B, ASN71J, ASP124B, ASP124J, ASP41B, ASP41J, GLN203B, GLN203J, GLN38B, GLN38J, GLN4B, GLN4J, GLU201B, GLU201J, GLU3B, GLU3J, GLU81B, GLU81J, GLY125B, GLY125J, GLY37B, GLY37J, ILE2B, ILE2J, ILE30B, ILE30J, ILE43B, ILE43J, ILE76B, ILE76J, LEU198B, LEU198J, LEU265B, LEU265J, LEU269B, LEU269J, LEU79B, LEU79J, LYS266B, LYS31B, LYS31J, LYS80B, LYS80J, MET1B, MET1J, MET204B, MET204J, PHE122B, PHE122J, PHE123B, PHE123J, PHE42B, PHE42J, PRO126B, PRO126J, PRO35B, PRO35J, PRO39B, PRO39J, SER121B, SER121J, THR34B, THR34J, TRP77B, TRP77J, TYR33B, TYR33J, TYR36B, TYR36J, VAL127B, VAL127J, VAL128B, VAL128J, VAL270B, VAL270J, VAL32B, VAL32J
• B-L: ARG61B, ARG61L, ARG64B, ARG64L, ASP41B, ASP41L, GLN38B, GLN38L, GLU29B, GLU29L, GLY37B, GLY37L, GLY60B, GLY60L, GLY62B, GLY62L, HIS59B, HIS59L, HIS63B, HIS63L, ILE65B, ILE65L, ILE70B, ILE70L, LYS31B, LYS31L, LYS69B, LYS69L, PHE42B, PHE42L, PRO39B, PRO39L, PRO66B, PRO66L, SER40B, SER40L, TYR19B, TYR19L
• C-K: ARG61C, ARG61K, ARG64C, ARG64K, ASP41C, ASP41K, GLN38C, GLN38K, GLU29C, GLU29K, GLY37C, GLY37K, GLY60C, GLY60K, GLY62C, GLY62K, HIS59C, HIS59K, HIS63C, HIS63K, ILE65C, ILE65K, ILE70C, ILE70K, LYS31C, LYS31K, LYS69C, LYS69K, PHE42C, PHE42K, PRO39C, PRO39K, PRO66C, PRO66K, SER40C, SER40K, TYR19C
• C-L: ALA129C, ALA129L, ALA199C, ALA199L, ALA202C, ALA202L, ALA268L, ALA74C, ALA74L, ALA78C, ALA78L, ARG64C, ARG64L, ARG73C, ARG73L, ASN71C, ASN71L, ASP124C, ASP124L, ASP41C, ASP41L, GLN203C, GLN203L, GLN38C, GLN38L, GLN4C, GLN4L, GLU201C, GLU201L, GLU3C, GLU3L, GLU81C, GLU81L, GLY125C, GLY125L, GLY37C, GLY37L, ILE2C, ILE2L, ILE30C, ILE30L, ILE43C, ILE43L, ILE76C, ILE76L, LEU198C, LEU198L, LEU265C, LEU265L, LEU269C, LEU269L, LEU79C, LEU79L, LYS266L, LYS31C, LYS31L, LYS80C, LYS80L, MET1C, MET1L, MET204C, MET204L, PHE122C, PHE122L, PHE123C, PHE123L, PHE42C, PHE42L, PRO126C, PRO126L, PRO35C, PRO35L, PRO39C, PRO39L, SER121C, SER121L, THR34C, THR34L, TRP77C, TRP77L, TYR33C, TYR33L, TYR36C, TYR36L, VAL127C, VAL127L, VAL128C, VAL128L, VAL270C, VAL270L, VAL32C, VAL32L
• D-E: ALA129E, ALA134E, ALA174D, ALA185E, ALA225D, ALA268E, ARG118D, ARG118E, ARG169D, ARG173D, ARG177D, ARG61D, ARG64D, ARG73E, ASN117D, ASN117E, ASN197E, ASP109E, ASP113E, ASP124E, ASP135E, ASP216D, CYS164E, CYS200E, GLN110E, GLU119E, GLU166D, GLU166E, GLU175D, GLU181D, GLU181E, GLU201E, GLU226D, GLU227D, GLY125E, GLY160E, GLY167D, GLY17D, GLY62D, HIS130E, HIS59D, HIS63D, HIS68D, ILE112E, ILE163D, ILE163E, ILE165D, ILE165E, ILE221D, ILE65D, LEU192E, LEU198E, LEU265E, LEU269E, LYS116D, LYS116E, LYS184E, LYS266E, LYS69D, MET114D, MET114E, MET133E, MET190D, PHE111E, PHE122E, PHE123E, PHE137E, PHE170D, PHE218D, PRO126E, PRO136E, PRO168D, PRO194E, PRO222D, PRO66D, PRO67D, SER121E, SER132E, SER16D, SER171D, SER176D, SER264E, THR115D, THR115E, THR161E, THR172D, THR178D, THR178E, THR191D, THR224D, THR229D, THR267E, TRP179D, TRP179E, TYR120D, TYR120E, TYR162E, TYR183D, TYR183E, VAL127E, VAL128E, VAL131E, VAL182D, VAL182E, VAL193E, VAL196E, VAL217D, VAL223D, VAL228D, VAL270E
• D-F: ALA129D, ALA134D, ALA174F, ALA185D, ALA225F, ALA268D, ARG118D, ARG118F, ARG169F, ARG173F, ARG177F, ARG180D, ARG61F, ARG64F, ARG73D, ASN117D, ASN117F, ASN197D, ASP109D, ASP113D, ASP124D, ASP135D, ASP216F, CYS164D, CYS200D, GLN110D, GLU119D, GLU166D, GLU166F, GLU175F, GLU181D, GLU181F, GLU201D, GLU226F, GLU227F, GLY125D, GLY160D, GLY167F, GLY17F, GLY62F, HIS130D, HIS59F, HIS63F, HIS68F, ILE112D, ILE112F, ILE163D, ILE163F, ILE165D, ILE165F, ILE221F, ILE65F, ILE70F, LEU192D, LEU198D, LEU265D, LEU269D, LYS116D, LYS116F, LYS184D, LYS266D, LYS69F, MET114D, MET114F, MET133D, MET190F, PHE111D, PHE122D, PHE123D, PHE137D, PHE170F, PHE218F, PRO126D, PRO136D, PRO168F, PRO194D, PRO222F, PRO66F, PRO67F, SER121D, SER132D, SER16F, SER171F, SER176F, THR115D, THR115F, THR161D, THR172F, THR178D, THR178F, THR191F, THR224F, THR229F, THR267D, TRP179D, TRP179F, TYR120D, TYR120F, TYR162D, TYR183D, TYR183F, VAL127D, VAL128D, VAL131D, VAL182D, VAL182F, VAL193D, VAL196D, VAL217F, VAL223F, VAL228F, VAL270D
• D-G: ARG61D, ARG61G, ARG64D, ARG64G, ASP41D, ASP41G, GLN38D, GLN38G, GLU29D, GLU29G, GLY37D, GLY37G, GLY60D, GLY60G, GLY62D, GLY62G, HIS59D, HIS59G, HIS63D, HIS63G, ILE65D, ILE65G, ILE70D, ILE70G, LYS31D, LYS31G, LYS69D, LYS69G, PHE42D, PHE42G, PRO39D, PRO39G, PRO66D, PRO66G, SER40D, SER40G, TYR19D, TYR19G, TYR36G
• D-H: ALA129D, ALA129H, ALA199D, ALA199H, ALA202D, ALA202H, ALA268H, ALA74D, ALA74H, ALA78D, ALA78H, ARG64D, ARG64H, ARG73D, ARG73H, ASN71D, ASN71H, ASP124D, ASP124H, ASP41D, ASP41H, GLN203D, GLN203H, GLN38D, GLN38H, GLN4D, GLN4H, GLU201D, GLU201H, GLU3D, GLU3H, GLU81D, GLU81H, GLY125D, GLY125H, GLY37D, GLY37H, ILE2D, ILE2H, ILE30D, ILE30H, ILE43D, ILE43H, ILE76D, ILE76H, LEU198D, LEU198H, LEU265D, LEU265H, LEU269D, LEU269H, LEU79D, LEU79H, LYS266H, LYS31D, LYS31H, LYS80D, LYS80H, MET1D, MET1H, MET204D, MET204H, PHE122D, PHE122H, PHE123D, PHE123H, PHE42D, PHE42H, PRO126D, PRO126H, PRO35D, PRO35H, PRO39D, PRO39H, SER121D, SER121H, SER40D, SER40H, THR34D, THR34H, TRP77D, TRP77H, TYR33D, TYR33H, TYR36D, TYR36H, VAL127D, VAL127H, VAL128D, VAL128H, VAL270D, VAL270H, VAL32D, VAL32H
• E-F: ALA129F, ALA134F, ALA174E, ALA185F, ALA225E, ALA268F, ARG118E, ARG118F, ARG169E, ARG173E, ARG177E, ARG61E, ARG64E, ARG73F, ASN117E, ASN117F, ASN197F, ASP109F, ASP113F, ASP124F, ASP135F, ASP216E, CYS164F, CYS200F, GLN110F, GLU119F, GLU166E, GLU166F, GLU175E, GLU181E, GLU181F, GLU201F, GLU226E, GLU227E, GLY125F, GLY160F, GLY167E, GLY17E, GLY62E, HIS130F, HIS59E, HIS63E, HIS68E, ILE112F, ILE163E, ILE163F, ILE165E, ILE165F, ILE221E, ILE65E, ILE70E, LEU192F, LEU198F, LEU265F, LEU269F, LYS116E, LYS116F, LYS184F, LYS266F, LYS69E, MET114E, MET114F, MET133F, MET190E, PHE111F, PHE122F, PHE123F, PHE137F, PHE170E, PHE218E, PRO126F, PRO136F, PRO168E, PRO194F, PRO222E, PRO66E, PRO67E, SER121F, SER132F, SER16E, SER171E, SER176E, THR115E, THR115F, THR161F, THR172E, THR178E, THR178F, THR191E, THR224E, THR229E, THR267F, TRP179E, TRP179F, TYR120E, TYR120F, TYR162F, TYR183E, TYR183F, VAL127F, VAL128F, VAL131F, VAL182E, VAL182F, VAL193F, VAL196F, VAL217E, VAL223E, VAL228E, VAL270F
• E-G: ALA129E, ALA129G, ALA199E, ALA199G, ALA202E, ALA202G, ALA268E, ALA74E, ALA74G, ALA78E, ALA78G, ARG64E, ARG64G, ARG73E, ARG73G, ASN71E, ASN71G, ASP124E, ASP124G, ASP41E, ASP41G, GLN203E, GLN203G, GLN38E, GLN38G, GLN4E, GLN4G, GLU201E, GLU201G, GLU3E, GLU3G, GLU81E, GLU81G, GLY125E, GLY125G, GLY37E, GLY37G, ILE2E, ILE2G, ILE30E, ILE30G, ILE43E, ILE43G, ILE76E, ILE76G, LEU198E, LEU198G, LEU265E, LEU265G, LEU269E, LEU269G, LEU79E, LEU79G, LYS266E, LYS31E, LYS31G, LYS80E, LYS80G, MET1E, MET1G, MET204E, MET204G, PHE122E, PHE122G, PHE123E, PHE123G, PHE42E, PHE42G, PRO126E, PRO126G, PRO35E, PRO35G, PRO39E, PRO39G, SER121E, SER121G, THR34E, THR34G, TRP77E, TRP77G, TYR33E, TYR33G, TYR36E, TYR36G, VAL127E, VAL127G, VAL128E, VAL128G, VAL270E, VAL270G, VAL32E, VAL32G
• E-I: ARG61E, ARG61I, ARG64E, ARG64I, ASP41E, ASP41I, GLN38E, GLN38I, GLU29E, GLU29I, GLY37E, GLY37I, GLY60E, GLY60I, GLY62E, GLY62I, HIS59E, HIS59I, HIS63E, HIS63I, ILE65E, ILE65I, ILE70E, ILE70I, LYS31E, LYS31I, LYS69E, LYS69I, PHE42E, PHE42I, PRO39E, PRO39I, PRO66E, PRO66I, SER40E, SER40I, TYR19E, TYR19I
• F-H: ARG61F, ARG61H, ARG64F, ARG64H, ASP41F, ASP41H, GLN38F, GLN38H, GLU29F, GLU29H, GLY37F, GLY37H, GLY60F, GLY60H, GLY62F, GLY62H, HIS59F, HIS59H, HIS63F, HIS63H, ILE65F, ILE65H, ILE70F, ILE70H, LYS31F, LYS31H, LYS69F, LYS69H, PHE42F, PHE42H, PRO39F, PRO39H, PRO66F, PRO66H, SER40F, SER40H, TYR19F, TYR19H, TYR36F, TYR36H
• F-I: ALA129F, ALA129I, ALA199F, ALA199I, ALA202F, ALA202I, ALA74F, ALA74I, ALA78F, ALA78I, ARG64F, ARG73F, ARG73I, ASN71F, ASN71I, ASP124F, ASP124I, ASP41F, ASP41I, GLN203F, GLN203I, GLN38F, GLN38I, GLN4F, GLN4I, GLU201F, GLU201I, GLU3F, GLU3I, GLU81F, GLU81I, GLY125F, GLY125I, GLY37F, GLY37I, ILE2F, ILE2I, ILE30F, ILE30I, ILE43F, ILE43I, ILE76F, ILE76I, LEU198F, LEU198I, LEU265F, LEU265I, LEU269F, LEU269I, LEU79F, LEU79I, LYS31F, LYS31I, LYS80F, LYS80I, MET1F, MET1I, MET204F, MET204I, PHE122F, PHE122I, PHE123F, PHE123I, PHE42F, PHE42I, PRO126F, PRO126I, PRO35F, PRO35I, PRO39F, PRO39I, SER121F, SER121I, SER40F, SER40I, THR34F, THR34I, TRP77F, TRP77I, TYR33F, TYR33I, TYR36F, TYR36I, VAL127F, VAL127I, VAL128F, VAL128I, VAL270F, VAL270I, VAL32F, VAL32I
• G-H: ALA129H, ALA134H, ALA174G, ALA185H, ALA225G, ALA268H, ARG118G, ARG118H, ARG169G, ARG173G, ARG177G, ARG177H, ARG61G, ARG64G, ARG73H, ASN117G, ASN117H, ASN197H, ASP109H, ASP113H, ASP124H, ASP135H, ASP216G, CYS164H, CYS200H, GLN110H, GLU119H, GLU166G, GLU166H, GLU175G, GLU181G, GLU181H, GLU201H, GLU226G, GLU227G, GLY125H, GLY160H, GLY167G, GLY17G, GLY62G, HIS130H, HIS59G, HIS63G, HIS68G, ILE112H, ILE163G, ILE163H, ILE165G, ILE165H, ILE221G, ILE65G, ILE70G, LEU192H, LEU198H, LEU265H, LEU269H, LYS116G, LYS116H, LYS184H, LYS266H, LYS69G, MET114G, MET114H, MET133H, MET190G, PHE111H, PHE122H, PHE123H, PHE137H, PHE170G, PHE218G, PRO126H, PRO136H, PRO168G, PRO194H, PRO222G, PRO66G, PRO67G, SER121H, SER132H, SER16G, SER171G, SER176G, THR115G, THR115H, THR161H, THR172G, THR178G, THR178H, THR191G, THR224G, THR229G, THR267H, TRP179G, TRP179H, TYR120H, TYR162H, TYR183G, TYR183H, VAL127H, VAL128H, VAL131H, VAL182G, VAL182H, VAL193H, VAL196H, VAL217G, VAL223G, VAL228G, VAL270H
• G-I: ALA129G, ALA134G, ALA174I, ALA185G, ALA225I, ALA268G, ARG118G, ARG118I, ARG169I, ARG173I, ARG177I, ARG61I, ARG64I, ARG73G, ASN117G, ASN117I, ASN197G, ASP109G, ASP113G, ASP124G, ASP135G, ASP216I, CYS164G, CYS200G, GLN110G, GLU119G, GLU166G, GLU166I, GLU175I, GLU181G, GLU181I, GLU201G, GLU226I, GLU227I, GLY125G, GLY160G, GLY167I, GLY17I, GLY62I, HIS130G, HIS59I, HIS63I, HIS68I, ILE112G, ILE163G, ILE165G, ILE165I, ILE221I, ILE65I, ILE70I, LEU192G, LEU198G, LEU265G, LEU269G, LYS116G, LYS116I, LYS184G, LYS266G, LYS69I, MET114G, MET114I, MET133G, MET190I, PHE111G, PHE122G, PHE123G, PHE137G, PHE170I, PHE218I, PRO126G, PRO136G, PRO168I, PRO194G, PRO222I, PRO66I, PRO67I, SER121G, SER132G, SER16I, SER171I, SER176I, THR115G, THR115I, THR161G, THR172I, THR178G, THR178I, THR191I, THR224I, THR229I, THR267G, TRP179G, TRP179I, TYR120G, TYR162G, TYR183G, TYR183I, VAL127G, VAL128G, VAL131G, VAL182G, VAL182I, VAL193G, VAL196G, VAL217I, VAL223I, VAL228I, VAL270G
• H-I: ALA129I, ALA134I, ALA174H, ALA185I, ALA225H, ALA268I, ARG118H, ARG118I, ARG169H, ARG173H, ARG177H, ARG180I, ARG61H, ARG64H, ARG73I, ASN117H, ASN117I, ASN197I, ASP109I, ASP113I, ASP124I, ASP135I, ASP216H, CYS164I, CYS200I, GLN110I, GLU119I, GLU166H, GLU166I, GLU175H, GLU181H, GLU181I, GLU201I, GLU226H, GLU227H, GLY125I, GLY160I, GLY167H, GLY17H, GLY62H, HIS130I, HIS59H, HIS63H, HIS68H, ILE112I, ILE163H, ILE163I, ILE165H, ILE165I, ILE221H, ILE65H, ILE70H, LEU192I, LEU198I, LEU265I, LEU269I, LYS116H, LYS116I, LYS184I, LYS266I, LYS69H, MET114H, MET114I, MET133I, MET190H, PHE111I, PHE122I, PHE123I, PHE137I, PHE170H, PHE218H, PRO126I, PRO136I, PRO168H, PRO194I, PRO222H, PRO66H, PRO67H, SER121I, SER132I, SER16H, SER171H, SER176H, SER264I, THR115H, THR115I, THR161I, THR172H, THR178H, THR178I, THR191H, THR224H, THR229H, THR267I, TRP179H, TRP179I, TYR120I, TYR162I, TYR183H, TYR183I, VAL127I, VAL128I, VAL131I, VAL182H, VAL182I, VAL193I, VAL196I, VAL217H, VAL223H, VAL228H, VAL270I
• J-K: ALA129K, ALA134K, ALA174J, ALA185K, ALA225J, ALA268K, ARG118J, ARG118K, ARG169J, ARG173J, ARG177J, ARG61J, ARG64J, ARG73K, ASN117J, ASN117K, ASN197K, ASP109K, ASP113K, ASP124K, ASP135K, ASP216J, CYS164K, CYS200K, GLN110K, GLU119K, GLU166J, GLU166K, GLU175J, GLU181J, GLU181K, GLU201K, GLU226J, GLU227J, GLY125K, GLY160K, GLY167J, GLY17J, GLY62J, HIS130K, HIS59J, HIS63J, HIS68J, ILE112K, ILE163J, ILE163K, ILE165J, ILE165K, ILE221J, ILE65J, ILE70J, LEU192K, LEU198K, LEU265K, LEU269K, LYS116J, LYS116K, LYS184K, LYS266K, LYS69J, MET114J, MET114K, MET133K, MET190J, PHE111K, PHE122K, PHE123K, PHE137K, PHE170J, PHE218J, PRO126K, PRO136K, PRO168J, PRO194K, PRO222J, PRO66J, PRO67J, SER121K, SER132K, SER16J, SER171J, SER176J, THR115J, THR115K, THR161K, THR172J, THR178J, THR178K, THR191J, THR224J, THR229J, THR267K, TRP179J, TRP179K, TYR120K, TYR162K, TYR183J, TYR183K, VAL127K, VAL128K, VAL131K, VAL182J, VAL182K, VAL193K, VAL196K, VAL217J, VAL223J, VAL228J, VAL270K
• J-L: ALA129J, ALA134J, ALA174L, ALA185J, ALA225L, ALA268J, ARG118J, ARG118L, ARG169L, ARG173L, ARG177L, ARG230L, ARG61L, ARG64L, ARG73J, ASN117J, ASN117L, ASN197J, ASP109J, ASP113J, ASP124J, ASP135J, ASP216L, CYS164J, CYS200J, GLN110J, GLU119J, GLU166J, GLU166L, GLU175L, GLU181J, GLU181L, GLU201J, GLU226L, GLU227L, GLY125J, GLY160J, GLY167L, GLY17L, GLY62L, HIS130J, HIS59L, HIS63L, HIS68L, ILE112J, ILE163J, ILE163L, ILE165J, ILE165L, ILE221L, ILE65L, ILE70L, LEU192J, LEU198J, LEU265J, LEU269J, LYS116J, LYS116L, LYS184J, LYS266J, LYS69L, MET114J, MET114L, MET133J, MET190L, PHE111J, PHE122J, PHE123J, PHE137J, PHE170L, PHE218L, PRO126J, PRO136J, PRO168L, PRO194J, PRO222L, PRO66L, PRO67L, SER121J, SER132J, SER16L, SER171L, SER176L, THR115J, THR115L, THR161J, THR172L, THR178J, THR178L, THR191L, THR224L, THR229L, THR267J, TRP179J, TRP179L, TYR120J, TYR120L, TYR162J, TYR183J, TYR183L, VAL127J, VAL128J, VAL131J, VAL182J, VAL182L, VAL193J, VAL196J, VAL217L, VAL223L, VAL228L, VAL270J
• K-L: ALA129L, ALA134L, ALA174K, ALA185L, ALA225K, ALA268L, ARG118K, ARG118L, ARG169K, ARG173K, ARG177K, ARG61K, ARG64K, ARG73L, ASN117K, ASN117L, ASN197L, ASP109L, ASP113L, ASP124L, ASP135L, ASP216K, CYS164L, CYS200L, GLN110L, GLU119L, GLU166K, GLU166L, GLU175K, GLU181K, GLU181L, GLU201L, GLU226K, GLU227K, GLY125L, GLY160L, GLY167K, GLY17K, GLY62K, HIS130L, HIS59K, HIS63K, HIS68K, ILE112L, ILE163L, ILE165K, ILE165L, ILE221K, ILE65K, ILE70K, LEU192L, LEU198L, LEU265L, LEU269L, LYS116K, LYS116L, LYS184K, LYS184L, LYS266L, LYS69K, MET114K, MET114L, MET133L, MET190K, PHE111L, PHE122L, PHE123L, PHE137L, PHE170K, PHE218K, PRO126L, PRO136L, PRO168K, PRO194L, PRO222K, PRO66K, PRO67K, SER121L, SER132L, SER16K, SER171K, SER176K, SER264L, THR115K, THR115L, THR161L, THR172K, THR178K, THR178L, THR191K, THR224K, THR229K, THR267L, TRP179K, TRP179L, TYR120L, TYR162L, TYR183K, TYR183L, VAL127L, VAL128L, VAL131L, VAL182K, VAL182L, VAL193L, VAL196L, VAL217K, VAL223K, VAL228K, VAL270L