2A7R

crystal structure of human guanosine monophosphate reductase 2 (gmpr2)

• Total interactions analyzed: 6
• Total true interactions: 4
• Strongest Interaction:
  • Chains: B-D
  • Int. Res.: 124
  • Norm. En. per Res.: -3.8061
• Hub Node: A(2)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-C	-89.1578	-5.5899	-366.951	-461.6987	123	40	7	15717	3	47	37
A-D	-94.2485	-61.6318	-323.326	-479.2064	132	34	9	16219	5	51	35
B-C	-102.9173	-33.6927	-378.507	-515.1171	138	28	8	16430	6	51	37
B-D	-76.085	-57.6232	-338.25	-471.9582	124	26	7	15848	4	41	34

Interface residues

• A-C: ALA131C, ALA206A, ALA229A, ALA231A, ALA234A, ALA236A, ALA321A, ARG189C, ARG18A, ARG21A, ARG258C, ARG27A, ARG313A, ARG329A, ARG330A, ARG335A, ARG335C, ASN132C, ASN158C, ASN6C, ASP11C, ASP14A, ASP14C, ASP207A, ASP227A, ASP307A, ASP5C, ASP7A, ASP7C, CYS186C, CYS224A, CYS316A, GLN198C, GLN338A, GLN338C, GLU136C, GLU163C, GLU167C, GLU204C, GLU326A, GLY133C, GLY162C, GLY179C, GLY181C, GLY193C, GLY195C, GLY226A, GLY233A, GLY235A, GLY310A, GLY311A, GLY320A, HIS137C, HIS210A, HIS3C, ILE180C, ILE308A, ILE312A, ILE334A, ILE4C, LEU10A, LEU10C, LEU16A, LEU17A, LEU199A, LEU24A, LEU327A, LYS13A, LYS13C, LYS190C, LYS191C, LYS20A, LYS230A, LYS25A, LYS261A, LYS9C, MET164C, MET1C, MET203A, MET244A, PHE12A, PHE138C, PHE232A, PHE333A, PRO182C, PRO197C, PRO19A, PRO225A, PRO2C, SER135C, SER200A, SER200C, SER223A, SER22A, SER26A, SER314A, SER328A, THR161C, THR187C, THR188C, THR192C, THR23A, THR315A, THR317A, THR331A, THR332A, THR337A, THR337C, TYR134C, TYR196C, TYR318A, VAL130C, VAL139C, VAL159C, VAL15A, VAL160C, VAL194C, VAL202A, VAL228A, VAL319A, VAL336A, VAL336C, VAL8C
• A-D: ALA131A, ALA206D, ALA229D, ALA231D, ALA234D, ALA236D, ALA283A, ALA287A, ALA321D, ARG189A, ARG18D, ARG21D, ARG27D, ARG286A, ARG313D, ARG329D, ARG330D, ARG335D, ASN132A, ASN158A, ASN6A, ASP11A, ASP11D, ASP14A, ASP14D, ASP207D, ASP227D, ASP307D, ASP5A, ASP7A, ASP7D, CYS224D, CYS316D, GLN198A, GLN338D, GLN339D, GLU136A, GLU163A, GLU166A, GLU167A, GLU204A, GLU284A, GLU289A, GLU326D, GLY133A, GLY162A, GLY179A, GLY181A, GLY193A, GLY195A, GLY226D, GLY233D, GLY235D, GLY310D, GLY311D, GLY320D, HIS137A, HIS210D, HIS3A, ILE180A, ILE308D, ILE312D, ILE334D, ILE4A, LEU10A, LEU10D, LEU168A, LEU16D, LEU170A, LEU17D, LEU199D, LEU24D, LEU327D, LYS13A, LYS13D, LYS190A, LYS191A, LYS20D, LYS230D, LYS25D, LYS9A, LYS9D, MET164A, MET1A, MET203D, MET244D, PHE12D, PHE138A, PHE232D, PHE333D, PRO182A, PRO197A, PRO19D, PRO225D, PRO2A, SER135A, SER171A, SER200A, SER200D, SER223D, SER22D, SER26D, SER288A, SER28D, SER314D, SER328D, THR161A, THR188A, THR192A, THR23D, THR315D, THR317D, THR331D, THR332D, THR337A, THR337D, TYR134A, TYR196A, TYR318D, VAL139A, VAL159A, VAL15D, VAL160A, VAL165A, VAL194A, VAL202D, VAL228D, VAL319D, VAL336A, VAL336D, VAL8A, VAL8D
• B-C: ALA131B, ALA206C, ALA229C, ALA231C, ALA234C, ALA236C, ALA283B, ALA321C, ARG189B, ARG18C, ARG21C, ARG27C, ARG286B, ARG306C, ARG313C, ARG329C, ARG330C, ARG335B, ARG335C, ASN132B, ASN158B, ASN6B, ASP11B, ASP14B, ASP14C, ASP207C, ASP227C, ASP307C, ASP5B, ASP7B, ASP7C, CYS186B, CYS224C, CYS316C, GLN198B, GLN338B, GLN338C, GLU136B, GLU163B, GLU166B, GLU167B, GLU204B, GLU284B, GLU289B, GLU29C, GLY133B, GLY162B, GLY179B, GLY181B, GLY193B, GLY195B, GLY226C, GLY233C, GLY235C, GLY310C, GLY311C, GLY320C, HIS137B, HIS210C, HIS3B, ILE180B, ILE308C, ILE312C, ILE334C, ILE4B, LEU10B, LEU10C, LEU168B, LEU16C, LEU170B, LEU17C, LEU199C, LEU24C, LEU327C, LYS13B, LYS13C, LYS143B, LYS190B, LYS191B, LYS20C, LYS230C, LYS25C, LYS9B, LYS9C, MET164B, MET1B, MET203C, MET244C, PHE12C, PHE138B, PHE232C, PHE333C, PRO182B, PRO197B, PRO19C, PRO225C, PRO2B, SER135B, SER200B, SER200C, SER223C, SER22C, SER26C, SER270B, SER288B, SER28C, SER314C, SER328C, THR161B, THR187B, THR188B, THR192B, THR23C, THR315C, THR317C, THR331C, THR332C, THR337B, THR337C, TYR134B, TYR196B, TYR285B, TYR318C, VAL130B, VAL139B, VAL159B, VAL15C, VAL160B, VAL165B, VAL194B, VAL202C, VAL228C, VAL30C, VAL319C, VAL336B, VAL336C, VAL8B, VAL8C
• B-D: ALA131D, ALA206B, ALA229B, ALA231B, ALA234B, ALA236B, ALA321B, ARG189D, ARG18B, ARG21B, ARG258D, ARG27B, ARG313B, ARG329B, ARG330B, ARG335B, ARG335D, ASN132D, ASN158D, ASN6D, ASP11B, ASP11D, ASP14B, ASP14D, ASP207B, ASP227B, ASP307B, ASP5D, ASP7D, CYS224B, CYS316B, GLN338B, GLU136D, GLU140D, GLU163D, GLU167D, GLU204D, GLY133D, GLY162D, GLY179D, GLY181D, GLY193D, GLY195D, GLY226B, GLY233B, GLY235B, GLY310B, GLY311B, GLY320B, HIS137D, HIS210B, HIS3D, ILE180D, ILE308B, ILE312B, ILE334B, ILE4D, LEU10B, LEU10D, LEU168D, LEU16B, LEU17B, LEU199B, LEU24B, LEU327B, LYS13B, LYS13D, LYS190D, LYS191D, LYS20B, LYS230B, LYS25B, LYS261B, LYS9B, LYS9D, MET164D, MET1D, MET203B, MET244B, PHE12B, PHE138D, PHE232B, PHE333B, PRO182D, PRO197D, PRO19B, PRO225B, PRO2D, SER135D, SER171D, SER200B, SER200D, SER223B, SER22B, SER26B, SER314B, SER328B, THR161D, THR187D, THR188D, THR192D, THR23B, THR315B, THR317B, THR331B, THR332B, THR337B, THR337D, TYR134D, TYR196D, TYR318B, VAL130D, VAL139D, VAL159D, VAL15B, VAL160D, VAL194D, VAL202B, VAL228B, VAL319B, VAL336B, VAL336D, VAL8B, VAL8D