2A6E

crystal structure of the t. thermophilus rna polymerase holoenzyme

• Total interactions analyzed: 66
• Total true interactions: 21
• Strongest Interaction:
  • Chains: B-C
  • Int. Res.: 36
  • Norm. En. per Res.: -4.0774
• Hub Node: A(3)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-21.6845	5.9756	-390.989	-406.6979	144	50	14	17677	0	27	34
A-C	-81.8302	-138.9111	-423.862	-644.6034	195	51	8	20330	16	120	98
A-D	0.0	2.3948	-0.6117	1.7831	7	0	0	101	0	6	4
B-C	-15.3556	-80.4728	-50.9587	-146.7871	36	4	0	1889	5	13	18
B-D	-13.9613	-114.3445	-135.524	-263.8298	110	27	8	7650	7	53	40
B-E	0.0	0.0	-0.1497	-0.1497	4	0	0	31	0	0	0
C-D	-321.8168	-240.8814	-2316.8	-2879.4982	758	250	80	102488	25	316	274
C-E	0.0	-33.8766	-16.3137	-50.1903	25	3	0	969	1	11	8
C-F	-29.9838	-43.6733	-268.541	-342.1981	168	35	9	13761	6	64	62
D-E	-69.7068	-75.8572	-514.499	-660.0629	172	53	22	23771	7	72	57
D-F	-132.7378	-226.3767	-761.628	-1120.7426	375	108	13	35745	19	212	160
K-L	-6.3839	1.1457	-373.596	-378.8342	141	34	16	16943	0	26	32
K-M	-52.3471	-140.5607	-376.945	-569.8528	191	42	7	18792	10	114	100
K-N	0.0	2.6262	-0.383	2.2432	6	0	0	77	0	7	5
L-M	-9.1513	-45.1564	-25.3652	-79.6729	27	3	0	1172	2	11	17
L-N	-16.1998	-78.2946	-200.053	-294.5475	125	24	8	9659	10	57	43
M-N	-368.453	-304.2507	-2121.73	-2794.4337	706	204	71	92709	30	281	239
M-O	-5.8918	-29.7883			4
M-P	-28.3185	46.6499			22
N-O	-131.698	-78.9563			38
N-P	-99.7206	-200.3929			83

Interface residues

• A-B: ALA214A, ALA214B, ALA8A, ALA8B, ARG14A, ARG14B, ARG189A, ARG189B, ARG219A, ARG219B, ARG30A, ARG30B, ARG41A, ARG41B, ARG42A, ARG42B, ASN212A, ASN212B, ASN227A, ASN227B, ASN38A, ASN38B, ASP191A, ASP191B, ASP193A, ASP193B, GLN188B, GLN213B, GLN229A, GLN229B, GLU154B, GLU216A, GLU216B, GLU220A, GLU220B, GLU22B, GLU29A, GLU29B, GLY149A, GLY149B, GLY157B, GLY31A, GLY31B, GLY33A, GLY33B, GLY37A, GLY37B, HIS156B, HIS221A, HIS221B, ILE199B, ILE217A, ILE217B, ILE43A, ILE43B, ILE48A, ILE48B, LEU195A, LEU195B, LEU197A, LEU197B, LEU208A, LEU208B, LEU211A, LEU211B, LEU218A, LEU218B, LEU222A, LEU222B, LEU25A, LEU25B, LEU28A, LEU28B, LEU36A, LEU36B, LEU40A, LEU40B, LEU44A, LEU44B, LEU45A, LEU6A, LYS155A, LYS155B, LYS5A, LYS5B, LYS7A, LYS7B, MET1A, PHE11A, PHE11B, PHE179A, PHE179B, PHE225A, PHE225B, PHE23A, PHE23B, PHE32A, PHE32B, PRO152B, PRO228A, PRO228B, PRO27A, PRO27B, PRO39A, PRO39B, PRO9A, PRO9B, SER226A, SER226B, SER46A, SER46B, SER47A, SER47B, SER4A, SER4B, THR12A, THR12B, THR15A, THR15B, THR190B, THR196B, THR223A, THR223B, THR35A, THR35B, TYR150A, TYR150B, TYR224A, TYR224B, VAL10A, VAL10B, VAL13A, VAL13B, VAL148A, VAL148B, VAL151B, VAL181A, VAL181B, VAL215A, VAL215B, VAL24A, VAL24B, VAL34A, VAL34B
• A-C: ALA153A, ALA164A, ALA169A, ALA178A, ALA604C, ALA656C, ALA747C, ALA828C, ARG14A, ARG175A, ARG176A, ARG198A, ARG30A, ARG41A, ARG42A, ARG573C, ARG610C, ARG627C, ARG640C, ARG642C, ARG697C, ARG744C, ARG802C, ARG831C, ARG929C, ARG939C, ARG945C, ARG978C, ASN163A, ASN38A, ASN609C, ASP168A, ASP183A, ASP191A, ASP193A, ASP607C, ASP638C, ASP698C, ASP738C, ASP74A, ASP857C, ASP863C, ASP937C, ASP976C, GLN180A, GLN639C, GLN829C, GLU108A, GLU133A, GLU134A, GLU154A, GLU182A, GLU22A, GLU29A, GLU64A, GLU692C, GLU693C, GLU739C, GLU73A, GLU748C, GLU77A, GLU796C, GLU84A, GLU856C, GLU932C, GLU940C, GLU942C, GLU981C, GLY135A, GLY136A, GLY149A, GLY157A, GLY31A, GLY33A, GLY37A, GLY608C, GLY70A, GLY746C, GLY797C, GLY798C, GLY864C, GLY931C, GLY933C, GLY935C, GLY977C, GLY980C, HIS128A, HIS63A, HIS704C, HIS860C, ILE162A, ILE165A, ILE199A, ILE43A, ILE572C, ILE611C, ILE68A, ILE703C, ILE705C, ILE745C, ILE78A, ILE799C, ILE79A, LEU132A, LEU192A, LEU195A, LEU197A, LEU28A, LEU36A, LEU44A, LEU45A, LEU625C, LEU62A, LEU655C, LEU694C, LEU695C, LEU80A, LEU861C, LYS155A, LYS194A, LYS605C, LYS696C, LYS72A, LYS750C, LYS830C, LYS832C, LYS83A, LYS928C, LYS930C, LYS938C, MET858C, PHE171A, PHE179A, PHE23A, PHE32A, PHE628C, PHE65A, PHE699C, PHE926C, PHE934C, PRO106A, PRO152A, PRO166A, PRO39A, PRO641C, PRO69A, PRO854C, PRO859C, PRO862C, PRO866C, PRO959C, PRO982C, SER172A, SER46A, SER47A, SER66A, THR131A, THR184A, THR190A, THR196A, THR35A, THR67A, THR701C, THR865C, THR979C, TRP200A, TYR150A, TYR20A, TYR895C, TYR925C, TYR975C, VAL151A, VAL167A, VAL170A, VAL174A, VAL177A, VAL181A, VAL24A, VAL34A, VAL606C, VAL612C, VAL61A, VAL643C, VAL644C, VAL645C, VAL71A, VAL75A, VAL76A, VAL800C, VAL801C, VAL827C, VAL855C, VAL867C, VAL936C, VAL941C
• A-D: ARG30A, GLU722D, GLY31A, GLY856D, HIS855D, ILE857D, LYS155A
• B-C: ARG30B, ARG41B, ARG42B, ARG939C, ARG978C, ASN38B, ASP183B, ASP191B, ASP193B, ASP857C, ASP976C, GLU29B, GLU692C, GLU693C, GLU856C, GLU942C, GLU981C, GLY31B, GLY33B, GLY977C, GLY980C, ILE852C, LEU853C, LYS696C, LYS851C, LYS938C, PHE179B, PHE32B, PRO39B, PRO854C, PRO982C, THR35B, THR979C, VAL181B, VAL34B, VAL855C
• B-D: ALA153B, ALA169B, ALA178B, ALA690D, ALA814D, ALA844D, ALA849D, ALA852D, ALA854D, ALA887D, ARG175B, ARG176B, ARG185B, ARG189B, ARG198B, ARG41B, ARG42B, ARG818D, ARG838D, ARG867D, ARG872D, ARG884D, ASN124B, ASN81B, ASN845D, ASP168B, ASP183B, ASP191B, ASP685D, ASP689D, ASP74B, ASP847D, GLN180B, GLN188B, GLN636D, GLU154B, GLU182B, GLU64B, GLU686D, GLU692D, GLU722D, GLU73B, GLU77B, GLU810D, GLU817D, GLU820D, GLU848D, GLU84B, GLU888D, GLY149B, GLY187B, GLY856D, HIS128B, HIS63B, HIS855D, ILE78B, ILE79B, ILE857D, ILE885D, LEU127B, LEU45B, LEU720D, LEU80B, LEU813D, LEU82B, LEU839D, LEU850D, LEU851D, LEU881D, LYS155B, LYS646D, LYS72B, LYS83B, LYS840D, PHE171B, PHE179B, PHE65B, PHE806D, PHE843D, PRO152B, PRO809D, PRO846D, SER172B, SER46B, SER47B, THR190B, THR834D, THR865D, TRP200B, TRP688D, TYR150B, TYR841D, TYR936D, TYR937D, VAL148B, VAL151B, VAL167B, VAL170B, VAL174B, VAL177B, VAL181B, VAL721D, VAL75B, VAL76B, VAL821D, VAL842D, VAL853D, VAL858D, VAL864D, VAL866D
• B-E: ARG185B, GLN49E, LYS194B, THR50E
• C-D: ALA1007C, ALA1024D, ALA1025C, ALA1028D, ALA1039C, ALA1042C, ALA1045C, ALA1046C, ALA1066C, ALA1069C, ALA1077D, ALA1082D, ALA1085D, ALA1089D, ALA1094C, ALA1096C, ALA1116C, ALA11D, ALA1220D, ALA1225D, ALA1226D, ALA1247D, ALA13D, ALA1438D, ALA1450D, ALA1451D, ALA1474D, ALA153C, ALA447C, ALA497C, ALA499C, ALA515C, ALA516D, ALA536D, ALA555C, ALA558C, ALA649D, ALA673D, ALA675C, ALA687C, ALA705D, ALA715D, ALA732C, ALA733C, ALA735D, ALA738D, ALA746D, ALA755D, ALA757D, ALA759D, ALA840C, ALA850C, ALA852D, ALA854D, ALA909C, ALA947C, ALA954D, ARG1008C, ARG1029D, ARG1031C, ARG1042D, ARG1058D, ARG1062D, ARG1063C, ARG1078D, ARG1086C, ARG1096D, ARG1119C, ARG1239D, ARG1470D, ARG1482D, ARG154C, ARG19D, ARG35D, ARG428C, ARG432C, ARG437C, ARG48D, ARG512C, ARG516C, ARG517C, ARG525D, ARG534D, ARG557C, ARG601D, ARG613D, ARG615D, ARG622D, ARG628D, ARG647D, ARG65D, ARG674D, ARG675D, ARG679D, ARG681D, ARG6D, ARG704D, ARG710D, ARG713C, ARG735C, ARG760D, ARG783D, ARG791C, ARG796D, ARG86D, ARG879C, ARG87D, ARG89D, ARG939C, ARG945C, ARG946C, ARG969D, ARG978C, ARG988D, ARG9D, ASN1014D, ASN1018D, ASN1031D, ASN1064C, ASN1107C, ASN1465D, ASN448C, ASN500C, ASN507D, ASN556C, ASN617D, ASN669D, ASN683C, ASN703D, ASN737D, ASN768D, ASN845C, ASN872C, ASN881C, ASP1003C, ASP1058C, ASP1059C, ASP1075C, ASP1083D, ASP1098C, ASP1100D, ASP1103C, ASP1106C, ASP1110C, ASP1457D, ASP324C, ASP326C, ASP426C, ASP429C, ASP523D, ASP531D, ASP533C, ASP553C, ASP554C, ASP579D, ASP583D, ASP605D, ASP624D, ASP680C, ASP682D, ASP686C, ASP714C, ASP736C, ASP739D, ASP741D, ASP743D, ASP753C, ASP784D, ASP837C, ASP859D, ASP862D, ASP907C, ASP952D, ASP953D, ASP968D, ASP976C, CYS1039D, CYS439C, CYS733D, GLN1018C, GLN1019C, GLN1026C, GLN1030C, GLN1033D, GLN1034D, GLN1037D, GLN1046D, GLN1050C, GLN1093C, GLN1100C, GLN1227D, GLN498C, GLN529D, GLN538C, GLN616D, GLN636D, GLN680D, GLN714D, GLN724D, GLN727D, GLN744D, GLN756D, GLN762D, GLN834C, GLN861D, GLN884C, GLN969C, GLN973D, GLN976D, GLU1002C, GLU1034C, GLU1036C, GLU1041C, GLU1051C, GLU1051D, GLU1054D, GLU1061C, GLU1063D, GLU1068C, GLU1069D, GLU1074C, GLU1078C, GLU1083C, GLU1091C, GLU1104C, GLU1113C, GLU1219D, GLU1449D, GLU1458D, GLU16D, GLU25D, GLU442C, GLU445C, GLU4D, GLU520C, GLU551C, GLU57D, GLU651D, GLU662D, GLU663D, GLU678D, GLU685C, GLU711C, GLU722D, GLU731C, GLU734D, GLU748C, GLU758D, GLU764C, GLU766C, GLU770C, GLU796C, GLU798D, GLU79D, GLU887C, GLU911C, GLU942C, GLU948C, GLU975D, GLU979D, GLU981C, GLU984C, GLY1011C, GLY1022C, GLY1027D, GLY1028C, GLY1029C, GLY1030D, GLY1033C, GLY1044C, GLY1050D, GLY1064D, GLY1073C, GLY1076D, GLY1080D, GLY1081D, GLY1092D, GLY1114C, GLY1218D, GLY1222D, GLY1230D, GLY1248D, GLY1454D, GLY1461D, GLY1469D, GLY1475D, GLY1477D, GLY24D, GLY424C, GLY436C, GLY446C, GLY450C, GLY519C, GLY532D, GLY533D, GLY612D, GLY620D, GLY627D, GLY634D, GLY681C, GLY70D, GLY712D, GLY723D, GLY742D, GLY752C, GLY77D, GLY788D, GLY795C, GLY797C, GLY818C, GLY836C, GLY844C, GLY847C, GLY856D, GLY875C, GLY883C, GLY91D, GLY938D, GLY946D, GLY950D, GLY951C, GLY956C, GLY970C, GLY985C, HIS1006C, HIS101D, HIS1047C, HIS1075D, HIS1103D, HIS1445D, HIS431C, HIS434C, HIS552C, HIS709D, HIS728C, HIS729D, HIS748D, HIS767D, HIS855D, HIS889C, HIS92D, HIS999C, ILE1016C, ILE102D, ILE1035D, ILE1060C, ILE1070C, ILE1071C, ILE1072D, ILE10D, ILE1111C, ILE1223D, ILE1452D, ILE1467D, ILE1472D, ILE18D, ILE438C, ILE449C, ILE452C, ILE496C, ILE49D, ILE513D, ILE523C, ILE53D, ILE547C, ILE606D, ILE631D, ILE676C, ILE688C, ILE713D, ILE726D, ILE754C, ILE761D, ILE785D, ILE786D, ILE792D, ILE827D, ILE84D, ILE852C, ILE857D, ILE870C, ILE885C, ILE905C, ILE914C, ILE947D, ILE949D, ILE951D, ILE956D, ILE983C, ILE987C, ILE992D, ILE9C, LEU1015C, LEU1020D, LEU1021C, LEU1038D, LEU1040C, LEU1044D, LEU1049C, LEU1053C, LEU1055C, LEU1065D, LEU1068D, LEU1086D, LEU1088C, LEU1092C, LEU1094D, LEU1095C, LEU1097C, LEU1098D, LEU1102C, LEU1115C, LEU1209D, LEU12D, LEU1435D, LEU1447D, LEU1459D, LEU1462D, LEU1468D, LEU1471D, LEU37D, LEU451C, LEU514D, LEU520D, LEU524D, LEU540D, LEU550C, LEU559C, LEU581D, LEU582D, LEU603D, LEU607D, LEU618D, LEU619D, LEU637D, LEU644D, LEU650D, LEU652D, LEU657D, LEU658D, LEU701D, LEU702D, LEU708D, LEU711D, LEU717C, LEU728D, LEU729C, LEU731D, LEU734C, LEU751D, LEU764D, LEU787D, LEU823D, LEU839C, LEU860D, LEU871C, LEU874C, LEU882C, LEU886C, LEU890C, LEU918C, LEU950C, LEU952C, LEU968C, LEU971D, LEU972D, LEU974C, LEU997C, LYS1004C, LYS1024C, LYS1047D, LYS1056C, LYS1072C, LYS1079D, LYS1090C, LYS1097D, LYS1105C, LYS1118C, LYS1455D, LYS1456D, LYS1463D, LYS17D, LYS2D, LYS38D, LYS3D, LYS518C, LYS537C, LYS54D, LYS621D, LYS646D, LYS64D, LYS654D, LYS659D, LYS660D, LYS671D, LYS698D, LYS716C, LYS71D, LYS750C, LYS780D, LYS797D, LYS799D, LYS7D, LYS816C, LYS828D, LYS82D, LYS838C, LYS846C, LYS851C, LYS910C, LYS915C, LYS935D, LYS938C, LYS949C, LYS971C, MET1000C, MET1005C, MET1023D, MET1035C, MET1045D, MET1052C, MET1238D, MET512D, MET527D, MET560C, MET564C, MET648D, MET677C, MET745D, MET763D, MET880C, MET90D, PHE1017D, PHE1027C, PHE1032C, PHE104D, PHE1053D, PHE1061D, PHE1071D, PHE1085C, PHE1112C, PHE425C, PHE50D, PHE535D, PHE540C, PHE549C, PHE614D, PHE653D, PHE656D, PHE679C, PHE684C, PHE736D, PHE740D, PHE754D, PHE906C, PHE939D, PHE941D, PRO1012C, PRO1016D, PRO1019D, PRO1020C, PRO1048D, PRO1056D, PRO1077C, PRO1079C, PRO1082C, PRO1108C, PRO1473D, PRO152C, PRO155C, PRO15D, PRO440C, PRO444C, PRO518D, PRO521C, PRO521D, PRO522D, PRO526D, PRO52D, PRO536C, PRO635D, PRO645D, PRO655D, PRO678C, PRO706D, PRO730D, PRO750D, PRO751C, PRO767C, PRO769C, PRO772D, PRO781D, PRO793C, PRO794C, PRO817C, PRO826D, PRO859C, PRO873C, PRO877C, PRO877D, PRO912C, PRO955C, PRO982C, PRO986C, SER1009C, SER1014C, SER1026D, SER1049D, SER1057C, SER1059D, SER1060D, SER1073D, SER1074D, SER1080C, SER1084C, SER1091D, SER1117C, SER1210D, SER1478D, SER14D, SER20D, SER22D, SER505D, SER535C, SER538D, SER602D, SER608D, SER626D, SER629D, SER725D, SER730C, SER752D, SER753D, SER765C, SER765D, SER782D, SER83D, SER878C, SER942D, SER945D, THR1010C, THR1017C, THR1048C, THR1052D, THR1054C, THR1066D, THR1084D, THR1088D, THR1095D, THR1101C, THR1443D, THR1444D, THR1448D, THR1476D, THR36D, THR433C, THR443C, THR453C, THR501C, THR537D, THR544C, THR604D, THR707D, THR715C, THR768C, THR81D, THR888C, THR940D, THR943D, THR944D, THR948D, THR979C, TRP1038C, TRP103D, TRP1434D, TRP21D, TRP511D, TRP996D, TYR1013C, TYR1015D, TYR1021D, TYR1043C, TYR1067C, TYR1070D, TYR1093D, TYR23D, TYR435C, TYR471C, TYR544D, TYR625D, TYR682C, TYR791D, TYR841D, TYR88D, TYR936D, TYR937D, TYR989D, VAL1001C, VAL1022D, VAL1037C, VAL1055D, VAL1057D, VAL1067D, VAL1076C, VAL1081C, VAL1087C, VAL1089C, VAL1099C, VAL1099D, VAL1106D, VAL1109C, VAL1221D, VAL1224D, VAL1246D, VAL1466D, VAL427C, VAL430C, VAL441C, VAL514C, VAL517D, VAL519D, VAL522C, VAL528D, VAL530D, VAL539C, VAL5D, VAL623D, VAL630D, VAL632D, VAL633D, VAL670D, VAL689C, VAL694D, VAL700D, VAL721D, VAL72D, VAL732D, VAL747D, VAL749C, VAL749D, VAL78D, VAL792C, VAL80D, VAL819C, VAL835C, VAL848C, VAL849C, VAL853D, VAL858D, VAL85D, VAL863D, VAL876C, VAL8D, VAL943C, VAL955D, VAL972C, VAL988C, VAL989C
• C-E: ALA1042C, ALA1045C, ALA1046C, ALA1069C, ALA24E, ALA27E, ARG32E, ASP1075C, GLN28E, GLU1041C, GLU1074C, GLU1078C, GLY1044C, GLY1073C, HIS1047C, LEU1040C, LEU31E, LYS16E, LYS25E, PRO1077C, THR20E, TYR1043C, TYR17E, VAL1076C, VAL21E
• C-F: ALA1065C, ALA1066C, ALA1069C, ALA275F, ALA344F, ALA345F, ALA366F, ALA370C, ALA404F, ARG1008C, ARG1031C, ARG1063C, ARG276F, ARG284F, ARG358C, ARG372F, ARG376C, ARG383C, ARG406F, ARG416F, ARG419F, ARG713C, ARG772C, ARG775C, ASN1064C, ASN374C, ASN402F, ASN448C, ASP323F, ASP331F, ASP335F, ASP343F, ASP377F, ASP420F, ASP423F, ASP714C, GLN1018C, GLN1019C, GLN1026C, GLN279F, GLN280F, GLN312F, GLN347F, GLN390C, GLU1061C, GLU1068C, GLU1083C, GLU281F, GLU285F, GLU305F, GLU306F, GLU318F, GLU324F, GLU336F, GLU352F, GLU353F, GLU379C, GLU401F, GLU412F, GLU421C, GLU764C, GLU770C, GLU771C, GLU780C, GLY1011C, GLY1022C, GLY1023C, GLY1062C, GLY283F, GLY330F, GLY374F, GLY378F, GLY779C, GLY818C, HIS117C, HIS337F, HIS411F, HIS728C, ILE1016C, ILE1060C, ILE1070C, ILE1071C, ILE310F, ILE333F, ILE376F, ILE777C, LEU1015C, LEU1021C, LEU1055C, LEU115C, LEU278F, LEU282F, LEU308F, LEU317F, LEU338F, LEU349F, LEU350F, LEU354F, LEU358F, LEU369F, LEU371F, LEU375F, LEU405F, LEU408F, LEU413C, LEU418F, LEU422F, LEU729C, LEU773C, LEU774C, LEU815C, LYS1024C, LYS1072C, LYS302F, LYS309F, LYS325F, LYS370F, LYS371C, LYS373F, LYS409F, LYS716C, LYS762C, LYS786C, LYS816C, MET367F, PHE114C, PHE328F, PHE332F, PHE421F, PHE778C, PHE78C, PRO1012C, PRO1020C, PRO286F, PRO334F, PRO339F, PRO341F, PRO369C, PRO377C, PRO767C, PRO769C, PRO77C, PRO817C, PRO93C, SER1009C, SER1014C, SER340F, SER348F, SER351F, SER375C, SER413F, SER730C, SER776C, THR1010C, THR1017C, THR346F, THR715C, THR768C, TYR1013C, TYR1067C, TYR288F, TYR329F, TYR410F, VAL113C, VAL342F, VAL368F, VAL373C, VAL819C
• D-E: ALA1220D, ALA1474D, ALA1494D, ALA1498D, ALA1502D, ALA24E, ALA27E, ALA2E, ALA60E, ALA64E, ALA690D, ALA755D, ALA757D, ALA759D, ALA766D, ALA928D, ARG1213D, ARG1482D, ARG1499D, ARG18E, ARG26E, ARG32E, ARG710D, ARG72E, ARG760D, ARG84E, ARG91E, ARG929D, ASN37E, ASN59E, ASN768D, ASN78E, ASP1479D, ASP1488D, ASP14E, ASP56E, ASP57E, ASP689D, ASP7E, ASP83E, ASP932D, GLN1202D, GLN1485D, GLN1489D, GLN28E, GLN29E, GLN49E, GLN641D, GLN717D, GLN756D, GLN762D, GLN86E, GLU1219D, GLU1496D, GLU1497D, GLU1501D, GLU3E, GLU41E, GLU61E, GLU663D, GLU67E, GLU692D, GLU693D, GLU758D, GLU77E, GLU82E, GLU88E, GLU90E, GLU925D, GLY11E, GLY1218D, GLY1475D, GLY1477D, GLY5E, GLY697D, GLY71E, GLY76E, GLY923D, HIS33E, HIS640D, HIS696D, HIS767D, ILE1217D, ILE1495D, ILE695D, ILE6E, ILE761D, ILE92E, LEU1209D, LEU1492D, LEU19E, LEU30E, LEU31E, LEU40E, LEU51E, LEU54E, LEU639D, LEU68E, LEU69E, LEU73E, LEU764D, LEU769D, LEU79E, LEU85E, LEU922D, LEU931D, LEU9E, LYS1490D, LYS1493D, LYS16E, LYS25E, LYS36E, LYS47E, LYS638D, LYS660D, LYS664D, LYS66E, LYS698D, LYS87E, LYS8E, LYS926D, MET1211D, MET48E, MET65E, MET763D, MET89E, MET924D, PHE10E, PHE1480D, PHE1483D, PHE656D, PHE754D, PHE75E, PHE919D, PRO1214D, PRO46E, PRO4E, PRO58E, PRO81E, SER1210D, SER1216D, SER1478D, SER15E, SER752D, SER753D, SER765D, THR1476D, THR1484D, THR1491D, THR20E, THR38E, THR50E, THR62E, THR927D, TRP63E, TYR17E, TYR93E, VAL1107D, VAL1215D, VAL1224D, VAL13E, VAL1481D, VAL1486D, VAL1487D, VAL21E, VAL22E, VAL23E, VAL39E, VAL694D, VAL699D, VAL74E, VAL80E
• D-F: ALA133F, ALA139F, ALA177F, ALA182F, ALA190F, ALA223F, ALA250F, ALA255F, ALA344F, ALA345F, ALA416D, ALA422D, ALA454D, ALA536D, ALA559D, ALA562D, ALA667D, ALA672D, ALA673D, ALA96D, ARG104F, ARG128F, ARG132F, ARG140F, ARG142F, ARG159D, ARG162D, ARG172F, ARG178F, ARG184F, ARG19D, ARG205F, ARG212D, ARG222F, ARG232F, ARG249F, ARG256F, ARG259F, ARG35D, ARG414D, ARG416F, ARG419F, ARG41D, ARG434D, ARG455D, ARG525D, ARG534D, ARG545D, ARG546D, ARG550D, ARG553D, ARG568D, ARG572D, ARG587D, ARG598D, ARG601D, ARG613D, ARG615D, ARG622D, ARG65D, ARG674D, ARG675D, ARG67D, ARG82F, ARG86D, ARG87D, ASN191F, ASN217F, ASN33D, ASN442D, ASN541D, ASN549D, ASN552D, ASN569D, ASN593D, ASN669D, ASP155D, ASP160F, ASP211F, ASP253F, ASP323F, ASP326F, ASP331F, ASP335F, ASP343F, ASP377F, ASP413D, ASP419D, ASP420F, ASP423D, ASP423F, ASP438D, ASP451D, ASP453D, ASP523D, ASP531D, ASP539D, ASP542D, ASP55D, ASP605D, ASP624D, ASP79F, CYS60D, GLN125D, GLN161F, GLN185F, GLN214F, GLN218F, GLN254F, GLN312F, GLN347F, GLN462D, GLN463D, GLN529D, GLN560D, GLN611D, GLN616D, GLN66D, GLN83F, GLN90F, GLU101F, GLU122D, GLU129F, GLU156D, GLU157F, GLU160D, GLU167D, GLU179F, GLU181F, GLU189F, GLU214D, GLU215F, GLU225F, GLU305F, GLU306F, GLU30D, GLU313F, GLU318F, GLU324F, GLU336F, GLU353F, GLU355F, GLU375D, GLU376D, GLU382D, GLU389D, GLU40D, GLU412F, GLU436D, GLU459D, GLU515D, GLU564D, GLU570D, GLU576D, GLU57D, GLU662D, GLU678D, GLU87F, GLU94D, GLU97F, GLU98F, GLY137F, GLY146F, GLY204F, GLY206F, GLY216F, GLY219F, GLY330F, GLY374F, GLY378F, GLY383D, GLY412D, GLY418D, GLY424D, GLY425D, GLY532D, GLY533D, GLY561D, GLY588D, GLY595D, GLY609D, GLY612D, GLY61D, GLY89F, HIS175F, HIS186F, HIS263F, HIS337F, HIS386D, HIS388D, HIS86F, ILE135F, ILE144F, ILE176F, ILE188F, ILE213F, ILE221F, ILE258F, ILE260F, ILE310F, ILE321F, ILE32D, ILE333F, ILE376F, ILE452D, ILE53D, ILE548D, ILE565D, ILE566D, ILE567D, ILE606D, ILE75F, ILE84D, ILE88F, LEU102F, LEU136F, LEU147F, LEU163F, LEU171D, LEU174F, LEU187F, LEU192F, LEU207F, LEU210F, LEU212F, LEU220F, LEU227D, LEU317F, LEU338F, LEU349F, LEU350F, LEU354F, LEU371F, LEU375F, LEU37D, LEU387D, LEU418F, LEU421D, LEU422F, LEU439D, LEU44D, LEU524D, LEU540D, LEU543D, LEU554D, LEU557D, LEU558D, LEU574D, LEU600D, LEU619D, LEU658D, LEU85F, LEU94F, LEU95D, LEU96F, LYS105F, LYS106D, LYS131D, LYS134F, LYS164F, LYS168F, LYS171F, LYS230F, LYS28D, LYS309F, LYS325F, LYS370F, LYS373F, LYS38D, LYS417F, LYS426D, LYS428D, LYS54D, LYS555D, LYS556D, LYS571D, LYS610D, LYS62D, LYS64D, LYS654D, LYS671D, LYS74F, LYS82D, MET264F, MET456D, MET527D, MET573D, MET676D, PHE129D, PHE209F, PHE328F, PHE332F, PHE421F, PHE45D, PHE535D, PHE68D, PRO145F, PRO167F, PRO261F, PRO29D, PRO314F, PRO320F, PRO334F, PRO339F, PRO341F, PRO390D, PRO417D, PRO526D, PRO52D, PRO563D, PRO594D, PRO599D, PRO655D, PRO668D, PRO80F, PRO92F, PRO98D, SER130D, SER138F, SER208F, SER316F, SER327F, SER340F, SER348F, SER351F, SER410D, SER538D, SER596D, SER76F, SER78F, SER83D, THR257F, THR319F, THR31D, THR346F, THR36D, THR415F, THR537D, THR592D, THR77F, THR97D, TYR132D, TYR158D, TYR163D, TYR169D, TYR173F, TYR215D, TYR229F, TYR329F, TYR34D, TYR625D, TYR63D, TYR84F, VAL100F, VAL126D, VAL131F, VAL141F, VAL195F, VAL196F, VAL224F, VAL315F, VAL342F, VAL377D, VAL384D, VAL385D, VAL409D, VAL420D, VAL427D, VAL435D, VAL437D, VAL528D, VAL530D, VAL670D, VAL81F, VAL91F
• K-L: ALA214K, ALA214L, ALA8K, ALA8L, ARG14K, ARG14L, ARG189K, ARG189L, ARG219K, ARG219L, ARG30K, ARG30L, ARG41K, ARG41L, ARG42K, ARG42L, ASN212K, ASN212L, ASN227K, ASN227L, ASN38K, ASN38L, ASP191K, ASP191L, ASP193K, ASP193L, GLN229K, GLN229L, GLU216K, GLU216L, GLU220K, GLU220L, GLU26K, GLU26L, GLU29K, GLU29L, GLY149L, GLY157L, GLY31K, GLY31L, GLY33K, GLY33L, GLY37K, GLY37L, HIS156L, HIS221K, HIS221L, ILE199L, ILE217K, ILE217L, ILE43K, ILE43L, ILE48K, ILE48L, LEU195K, LEU195L, LEU197K, LEU197L, LEU208K, LEU208L, LEU211K, LEU211L, LEU218K, LEU218L, LEU222K, LEU222L, LEU25K, LEU25L, LEU28K, LEU28L, LEU36K, LEU36L, LEU40K, LEU40L, LEU44K, LEU44L, LEU45L, LEU6K, LEU6L, LYS155K, LYS155L, LYS5K, LYS5L, LYS7K, LYS7L, MET1K, PHE11K, PHE11L, PHE171L, PHE179K, PHE225K, PHE225L, PHE23K, PHE23L, PHE32K, PHE32L, PRO152L, PRO228K, PRO228L, PRO27K, PRO27L, PRO39K, PRO39L, PRO9K, PRO9L, SER226K, SER226L, SER46K, SER46L, SER47K, SER47L, SER4K, SER4L, THR12K, THR12L, THR15K, THR196K, THR196L, THR223K, THR223L, THR35K, THR35L, TYR150K, TYR150L, TYR224K, TYR224L, VAL10K, VAL10L, VAL13K, VAL13L, VAL148K, VAL148L, VAL151L, VAL181K, VAL181L, VAL215K, VAL215L, VAL24K, VAL24L, VAL34K, VAL34L
• K-M: ALA153K, ALA164K, ALA169K, ALA178K, ALA604M, ALA636M, ALA747M, ALA828M, ARG14K, ARG161K, ARG175K, ARG176K, ARG198K, ARG30K, ARG41K, ARG42K, ARG573M, ARG610M, ARG626M, ARG627M, ARG640M, ARG642M, ARG697M, ARG744M, ARG802M, ARG831M, ARG929M, ARG939M, ARG978M, ASN163K, ASN38K, ASN609M, ASN81K, ASP168K, ASP183K, ASP191K, ASP193K, ASP607M, ASP638M, ASP698M, ASP74K, ASP857M, ASP863M, ASP937M, ASP976M, GLN180K, GLN639M, GLN647M, GLN829M, GLU108K, GLU133K, GLU134K, GLU154K, GLU182K, GLU22K, GLU29K, GLU64K, GLU692M, GLU693M, GLU73K, GLU748M, GLU77K, GLU84K, GLU856M, GLU932M, GLU940M, GLU981M, GLY135K, GLY136K, GLY149K, GLY157K, GLY31K, GLY33K, GLY37K, GLY608M, GLY646M, GLY70K, GLY746M, GLY798M, GLY864M, GLY931M, GLY933M, GLY935M, GLY977M, GLY980M, HIS128K, HIS63K, HIS704M, HIS860M, ILE162K, ILE165K, ILE43K, ILE572M, ILE611M, ILE68K, ILE703M, ILE705M, ILE745M, ILE799M, ILE79K, LEU132K, LEU192K, LEU195K, LEU28K, LEU44K, LEU45K, LEU625M, LEU62K, LEU655M, LEU694M, LEU695M, LEU80K, LEU861M, LYS155K, LYS159K, LYS194K, LYS605M, LYS696M, LYS72K, LYS750M, LYS830M, LYS832M, LYS83K, LYS928M, LYS930M, LYS938M, MET858M, PHE171K, PHE179K, PHE23K, PHE32K, PHE628M, PHE65K, PHE699M, PHE896M, PHE934M, PRO106K, PRO152K, PRO166K, PRO39K, PRO641M, PRO69K, PRO854M, PRO859M, PRO862M, PRO866M, PRO982M, SER172K, SER46K, SER47K, SER66K, SER702M, THR131K, THR184K, THR190K, THR196K, THR35K, THR67K, THR701M, THR865M, THR979M, TRP200K, TYR150K, TYR20K, TYR895M, TYR975M, VAL151K, VAL167K, VAL170K, VAL174K, VAL177K, VAL181K, VAL24K, VAL34K, VAL603M, VAL606M, VAL612M, VAL61K, VAL643M, VAL644M, VAL645M, VAL71K, VAL75K, VAL76K, VAL800M, VAL801M, VAL827M, VAL855M, VAL867M, VAL936M, VAL941M
• K-N: ARG30K, GLU722N, GLY856N, HIS855N, ILE857N, LYS155K
• L-M: ARG30L, ARG42L, ARG939M, ARG978M, ASN38L, ASP183L, ASP191L, ASP857M, ASP976M, GLU29L, GLU692M, GLU856M, GLU981M, GLY31L, GLY977M, GLY980M, ILE852M, LEU853M, LYS851M, PHE179L, PHE32L, PRO39L, PRO854M, PRO982M, THR35L, THR979M, VAL34L
• L-N: ALA153L, ALA169L, ALA178L, ALA690N, ALA812N, ALA814N, ALA844N, ALA849N, ALA852N, ALA854N, ALA887N, ARG175L, ARG176L, ARG185L, ARG189L, ARG198L, ARG41L, ARG42L, ARG818N, ARG838N, ARG867N, ARG872N, ARG884N, ASN124L, ASN81L, ASN845N, ASP168L, ASP183L, ASP191L, ASP202L, ASP685N, ASP689N, ASP74L, ASP847N, GLN180L, GLN188L, GLN636N, GLN727N, GLU154L, GLU182L, GLU64L, GLU686N, GLU692N, GLU693N, GLU722N, GLU73L, GLU77L, GLU810N, GLU817N, GLU820N, GLU848N, GLU84L, GLU888N, GLU891N, GLY149L, GLY187L, GLY856N, HIS128L, HIS63L, HIS855N, ILE129L, ILE78L, ILE79L, ILE857N, ILE880N, ILE885N, LEU127L, LEU44L, LEU45L, LEU62L, LEU691N, LEU720N, LEU80L, LEU813N, LEU82L, LEU839N, LEU850N, LEU851N, LEU85L, LEU881N, LYS155L, LYS638N, LYS646N, LYS72L, LYS83L, LYS840N, PHE171L, PHE179L, PHE65L, PHE806N, PHE843N, PRO152L, PRO173L, PRO809N, PRO846N, SER172L, SER46L, SER47L, SER66L, THR190L, THR67L, THR834N, THR865N, TRP200L, TRP688N, TYR150L, TYR841N, TYR936N, TYR937N, VAL148L, VAL151L, VAL167L, VAL170L, VAL174L, VAL177L, VAL181L, VAL719N, VAL721N, VAL75L, VAL76L, VAL821N, VAL842N, VAL853N, VAL858N, VAL866N
• M-N: ALA1007M, ALA1024N, ALA1025M, ALA1028N, ALA1039M, ALA1042M, ALA1045M, ALA1046M, ALA1066M, ALA1069M, ALA1077N, ALA1082N, ALA1085N, ALA1089N, ALA1094M, ALA1096M, ALA1116M, ALA11N, ALA1220N, ALA1225N, ALA1226N, ALA13N, ALA1438N, ALA447M, ALA497M, ALA499M, ALA515M, ALA516N, ALA555M, ALA558M, ALA580N, ALA59N, ALA649N, ALA672N, ALA673N, ALA675M, ALA687M, ALA705N, ALA715N, ALA732M, ALA733M, ALA735N, ALA738N, ALA746N, ALA747M, ALA755N, ALA757N, ALA759N, ALA840M, ALA850M, ALA909M, ALA954N, ARG1008M, ARG1029N, ARG1031M, ARG1042N, ARG1062N, ARG1063M, ARG1078N, ARG1086M, ARG1096N, ARG1119M, ARG1239N, ARG19N, ARG35N, ARG422M, ARG428M, ARG432M, ARG437M, ARG48N, ARG512M, ARG516M, ARG525N, ARG534N, ARG557M, ARG601N, ARG613N, ARG615N, ARG622N, ARG628N, ARG647N, ARG65N, ARG674N, ARG675N, ARG679N, ARG681N, ARG6N, ARG704N, ARG710N, ARG713M, ARG735M, ARG760N, ARG772M, ARG775M, ARG783N, ARG791M, ARG796N, ARG831M, ARG86N, ARG879M, ARG87N, ARG89N, ARG939M, ARG945M, ARG946M, ARG978M, ARG9N, ASN1014N, ASN1018N, ASN1031N, ASN1107M, ASN448M, ASN500M, ASN507N, ASN556M, ASN617N, ASN669N, ASN683M, ASN703N, ASN737N, ASN768N, ASN845M, ASN872M, ASN881M, ASP1003M, ASP1058M, ASP1059M, ASP1075M, ASP1083N, ASP1098M, ASP1100N, ASP1103M, ASP1106M, ASP1110M, ASP324M, ASP426M, ASP429M, ASP523N, ASP531N, ASP533M, ASP553M, ASP554M, ASP55N, ASP579N, ASP583N, ASP605N, ASP624N, ASP680M, ASP682N, ASP686M, ASP714M, ASP736M, ASP739N, ASP741N, ASP743N, ASP753M, ASP784N, ASP787M, ASP837M, ASP859N, ASP862N, ASP907M, ASP952N, ASP953N, ASP976M, CYS1039N, CYS439M, CYS58N, CYS733N, GLN1018M, GLN1019M, GLN1026M, GLN1030M, GLN1033N, GLN1034N, GLN1037N, GLN1050M, GLN1093M, GLN1100M, GLN1227N, GLN498M, GLN529N, GLN538M, GLN616N, GLN636N, GLN66N, GLN680N, GLN714N, GLN724N, GLN727N, GLN744N, GLN756N, GLN762N, GLN834M, GLN861N, GLN884M, GLN969M, GLU1002M, GLU1034M, GLU1036M, GLU1041M, GLU1051M, GLU1051N, GLU1054N, GLU1061M, GLU1063N, GLU1068M, GLU1069N, GLU1074M, GLU1078M, GLU1083M, GLU1091M, GLU1104M, GLU1113M, GLU1219N, GLU25N, GLU442M, GLU445M, GLU47N, GLU491M, GLU4N, GLU515N, GLU520M, GLU551M, GLU57N, GLU651N, GLU662N, GLU663N, GLU678N, GLU685M, GLU711M, GLU722N, GLU731M, GLU734N, GLU748M, GLU758N, GLU764M, GLU766M, GLU770M, GLU771M, GLU796M, GLU798N, GLU79N, GLU887M, GLU911M, GLU942M, GLU948M, GLU975N, GLU979N, GLU981M, GLU984M, GLY1011M, GLY1022M, GLY1027N, GLY1028M, GLY1029M, GLY1030N, GLY1033M, GLY1044M, GLY1064N, GLY1073M, GLY1076N, GLY1080N, GLY1081N, GLY1092N, GLY1114M, GLY1218N, GLY1222N, GLY1230N, GLY24N, GLY424M, GLY436M, GLY446M, GLY450M, GLY519M, GLY532N, GLY533N, GLY612N, GLY61N, GLY620N, GLY627N, GLY634N, GLY681M, GLY70N, GLY712N, GLY723N, GLY742N, GLY752M, GLY763M, GLY77N, GLY788N, GLY795M, GLY797M, GLY798M, GLY818M, GLY836M, GLY844M, GLY847M, GLY856N, GLY875M, GLY883M, GLY91N, GLY938N, GLY946N, GLY950N, GLY951M, GLY970M, GLY985M, HIS1006M, HIS101N, HIS1047M, HIS1075N, HIS1103N, HIS431M, HIS434M, HIS552M, HIS709N, HIS728M, HIS729N, HIS748N, HIS767N, HIS889M, HIS999M, ILE1016M, ILE102N, ILE1035N, ILE1060M, ILE1070M, ILE1071M, ILE1072N, ILE10N, ILE1111M, ILE1223N, ILE18N, ILE438M, ILE449M, ILE452M, ILE496M, ILE49N, ILE513N, ILE523M, ILE53N, ILE547M, ILE606N, ILE631N, ILE676M, ILE683N, ILE688M, ILE713N, ILE726M, ILE726N, ILE754M, ILE761N, ILE785N, ILE786N, ILE792N, ILE827N, ILE84N, ILE852M, ILE857N, ILE870M, ILE885M, ILE905M, ILE914M, ILE947N, ILE949N, ILE951N, ILE956N, ILE983M, ILE987M, ILE9M, LEU1015M, LEU1020N, LEU1021M, LEU1038N, LEU1040M, LEU1049M, LEU1053M, LEU1055M, LEU1065N, LEU1068N, LEU1086N, LEU1088M, LEU1092M, LEU1094N, LEU1095M, LEU1097M, LEU1102M, LEU1115M, LEU1209N, LEU12N, LEU1435N, LEU328M, LEU37N, LEU451M, LEU514N, LEU520N, LEU524N, LEU540N, LEU550M, LEU559M, LEU581N, LEU582N, LEU603N, LEU607N, LEU618N, LEU619N, LEU637N, LEU644N, LEU650N, LEU652N, LEU657N, LEU658N, LEU677N, LEU701N, LEU708N, LEU711N, LEU717M, LEU728N, LEU729M, LEU731N, LEU734M, LEU737M, LEU751N, LEU764N, LEU787N, LEU839M, LEU860N, LEU871M, LEU874M, LEU882M, LEU886M, LEU950M, LEU952M, LEU968M, LEU971N, LEU974M, LEU997M, LYS1004M, LYS1047N, LYS1056M, LYS1072M, LYS1079N, LYS1090M, LYS1097N, LYS1105M, LYS1118M, LYS1456N, LYS1463N, LYS17N, LYS2N, LYS38N, LYS3N, LYS518M, LYS537M, LYS54N, LYS621N, LYS646N, LYS64N, LYS654N, LYS659N, LYS660N, LYS671N, LYS698N, LYS716M, LYS71N, LYS750M, LYS780N, LYS7N, LYS816M, LYS828N, LYS82N, LYS838M, LYS846M, LYS851M, LYS910M, LYS915M, LYS935N, LYS949M, LYS971M, MET1000M, MET1005M, MET1023N, MET1035M, MET1052M, MET1238N, MET512N, MET527N, MET560M, MET564M, MET648N, MET677M, MET745N, MET763N, MET880M, MET90N, PHE1017N, PHE1027M, PHE1032M, PHE104N, PHE1053N, PHE1061N, PHE1071N, PHE1085M, PHE1112M, PHE425M, PHE535N, PHE540M, PHE549M, PHE614N, PHE653N, PHE656N, PHE679M, PHE684M, PHE736N, PHE740N, PHE754N, PHE906M, PHE939N, PHE941N, PRO1012M, PRO1016N, PRO1019N, PRO1020M, PRO1048N, PRO1077M, PRO1079M, PRO1082M, PRO1108M, PRO155M, PRO15N, PRO440M, PRO444M, PRO518N, PRO521M, PRO521N, PRO522N, PRO526N, PRO536M, PRO635N, PRO645N, PRO655N, PRO678M, PRO706N, PRO730N, PRO750N, PRO751M, PRO767M, PRO769M, PRO772N, PRO781N, PRO793M, PRO794M, PRO817M, PRO826N, PRO859M, PRO873M, PRO877M, PRO877N, PRO912M, PRO982M, PRO986M, SER1009M, SER1014M, SER1026N, SER1049N, SER1057M, SER1059N, SER1060N, SER1073N, SER1074N, SER1084M, SER1091N, SER1117M, SER1210N, SER1228N, SER14N, SER20N, SER22N, SER454M, SER505N, SER535M, SER538N, SER602N, SER608N, SER626N, SER629N, SER725N, SER730M, SER752N, SER753N, SER765M, SER765N, SER782N, SER83N, SER878M, SER942N, SER945N, THR1010M, THR1017M, THR1048M, THR1054M, THR1066N, THR1084N, THR1088N, THR1095N, THR1101M, THR1240N, THR1476N, THR36N, THR433M, THR443M, THR453M, THR501M, THR544M, THR604N, THR707N, THR715M, THR768M, THR81N, THR888M, THR940N, THR943N, THR944N, THR948N, THR979M, TRP1038M, TRP103N, TRP1434N, TRP21N, TRP511N, TYR1013M, TYR1015N, TYR1021N, TYR1043M, TYR1067M, TYR1070N, TYR1093N, TYR23N, TYR34N, TYR435M, TYR471M, TYR544N, TYR56N, TYR625N, TYR682M, TYR791N, TYR841N, TYR88N, TYR936N, VAL1001M, VAL1022N, VAL1037M, VAL1055N, VAL1067N, VAL1076M, VAL1081M, VAL1087M, VAL1089M, VAL1099M, VAL1099N, VAL1109M, VAL1221N, VAL1224N, VAL1246N, VAL427M, VAL430M, VAL441M, VAL514M, VAL517N, VAL519N, VAL522M, VAL528N, VAL530N, VAL539M, VAL578N, VAL5N, VAL623N, VAL630N, VAL632N, VAL633N, VAL670N, VAL689M, VAL694N, VAL700N, VAL721N, VAL72N, VAL732N, VAL747N, VAL749M, VAL749N, VAL792M, VAL819M, VAL835M, VAL848M, VAL849M, VAL853N, VAL858N, VAL85N, VAL876M, VAL8N, VAL943M, VAL955N, VAL972M, VAL988M, VAL989M
• M-O: ARG32O, ASP1075M, GLU1074M, GLU61O
• M-P: ARG276P, ARG376M, ARG772M, ARG775M, ASP335P, ASP423P, ASP714M, GLU285P, GLU305P, GLU336P, GLU379M, GLU764M, GLU770M, GLU771M, GLY818M, HIS337P, HIS728M, ILE333P, LEU1015M, LYS373P, LYS762M, TYR1013M
• N-O: ARG1213N, ARG18O, ARG26O, ARG72O, ARG760N, ASP1488N, ASP56O, ASP57O, ASP7O, GLN1485N, GLU1219N, GLU1497N, GLU3O, GLU61O, GLU663N, GLU67O, GLU693N, GLU88O, GLU925N, GLY76O, HIS640N, HIS767N, ILE1217N, LYS1490N, LYS16O, LYS25O, LYS698N, LYS8O, LYS926N, MET924N, PHE1480N, SER15O, THR1484N, THR50O, THR62O, VAL1487N, VAL74O, VAL80O
• N-P: ALA416N, ARG132P, ARG140P, ARG159N, ARG178P, ARG184P, ARG232P, ARG256P, ARG259P, ARG455N, ARG545N, ARG546N, ARG550N, ARG553N, ARG572N, ARG587N, ARG598N, ARG601N, ARG622N, ARG675N, ARG86N, ASN569N, ASN593N, ASP155N, ASP160P, ASP211P, ASP331P, ASP377P, ASP419N, ASP420P, ASP423N, ASP423P, ASP438N, ASP453N, ASP523N, ASP539N, ASP542N, ASP55N, ASP79P, GLN254P, GLN560N, GLU101P, GLU156N, GLU179P, GLU189P, GLU214N, GLU215P, GLU30N, GLU313P, GLU318P, GLU324P, GLU389N, GLU40N, GLU436N, GLU459N, GLU564N, GLU570N, GLU87P, GLU97P, GLY206P, HIS175P, HIS337P, HIS86P, LEU317P, LYS131N, LYS134P, LYS164P, LYS168P, LYS171P, LYS426N, LYS54N, LYS610N, LYS62N, LYS64N, LYS671N, LYS74P, LYS82N, SER208P, SER316P, THR537N, TYR84P, VAL315P, VAL384N