2A27

human drp-1 kinase, w305s s308a d40 mutant, crystal form with 8 monomers in the asymmetric unit

• Total interactions analyzed: 28
• Total true interactions: 7
• Strongest Interaction:
  • Chains: F-H
  • Int. Res.: 140
  • Norm. En. per Res.: -2.8116
• Hub Node: A(2)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	0.0	16.4317	-152.964	-136.5323	94	2	3	6810	0	44	53
A-E	-45.0926	-58.0136	-274.985	-378.0912	141	3	9	12610	3	48	67
B-C	-46.08	-52.5284	-273.778	-372.3865	138	7	9	12652	2	48	67
C-D	0.0	15.9443	-147.105	-131.1607	87	6	2	6767	0	45	54
D-G	-32.9378	-52.0898	-282.34	-367.3675	142	27	9	13006	1	51	65
E-F	0.0	31.0939	-164.417	-133.3231	90	4	1	7036	0	47	57
F-H	-35.0241	-50.1181	-308.482	-393.6242	140	21	8	13547	1	54	67

Interface residues

• A-B: ARG271B, ARG286A, ARG286B, ARG31A, ARG31B, ASN75A, ASN75B, ASP125A, ASP125B, ASP149A, ASP149B, GLN122A, GLN122B, GLN70B, GLU114A, GLU114B, GLU115A, GLU115B, GLU32A, GLU32B, GLU38A, GLU38B, GLU94A, GLU94B, GLY36A, GLY36B, HIS156A, HIS156B, HIS73A, HIS73B, HIS74A, HIS74B, HIS80A, HIS80B, ILE120A, ILE120B, ILE123A, ILE123B, ILE152A, ILE152B, ILE154A, ILE154B, ILE157A, ILE157B, ILE275A, ILE275B, LEU124A, LEU124B, LEU148A, LEU148B, LEU270A, LEU270B, LEU37A, LEU37B, LEU72A, LEU72B, LEU79A, LEU95A, LEU95B, LYS121A, LYS121B, LYS133B, LYS33A, LYS33B, LYS5A, PHE119A, PHE119B, PHE12A, PHE12B, PRO153A, PRO153B, PRO155A, PRO155B, PRO277A, PRO277B, SER118A, SER118B, SER34A, SER34B, THR117A, THR117B, THR276A, THR276B, THR35A, THR35B, THR78A, THR78B, TYR129A, TYR129B, TYR13A, TYR39A, TYR39B, VAL71A, VAL71B
• A-E: ALA214A, ALA214E, ALA227A, ALA227E, ALA231A, ALA231E, ALA51A, ALA51E, ARG302A, ARG302E, ARG303A, ARG303E, ARG304A, ARG304E, ARG47A, ARG47E, ARG50A, ARG50E, ARG53A, ARG53E, ARG54A, ARG54E, ARG58A, ARG58E, ARG63A, ARG63E, ASN144A, ASN144E, ASN176A, ASN176E, ASN190A, ASN190E, ASN228A, ASN228E, ASP220A, ASP220E, GLN223A, GLN223E, GLN23A, GLN23E, GLN299A, GLN299E, GLN48A, GLN48E, GLU100A, GLU100E, GLU143A, GLU143E, GLU173A, GLU173E, GLU182A, GLU182E, GLU192A, GLU192E, GLU224A, GLU224E, GLU59A, GLU59E, GLU60A, GLU60E, GLY179A, GLY179E, GLY219A, GLY219E, HIS166A, HIS166E, ILE177A, ILE177E, ILE188A, ILE188E, ILE229A, ILE229E, LEU164A, LEU164E, LEU194A, LEU194E, LEU218A, LEU218E, LEU226A, LEU226E, LYS141A, LYS141E, LYS175A, LYS175E, LYS222A, LYS222E, LYS258A, LYS258E, LYS298A, LYS298E, LYS45E, PHE174A, PHE174E, PHE178A, PHE178E, PHE183A, PHE183E, PHE217A, PHE217E, PHE240A, PHE240E, PHE24A, PHE24E, PRO142A, PRO142E, PRO181A, PRO181E, PRO186A, PRO186E, PRO216A, PRO216E, SER215A, SER215E, SER305A, SER49A, SER49E, SER52A, SER52E, SER57A, SER57E, THR180A, THR180E, THR221A, THR221E, THR225A, THR225E, THR230A, THR230E, THR87E, TYR191A, TYR191E, TYR300A, TYR300E, VAL172A, VAL172E, VAL184A, VAL184E, VAL189A, VAL189E, VAL301A, VAL301E
• B-C: ALA214B, ALA214C, ALA227B, ALA227C, ALA231B, ALA231C, ALA51B, ALA51C, ARG302B, ARG302C, ARG303B, ARG303C, ARG304B, ARG304C, ARG47B, ARG47C, ARG50B, ARG50C, ARG53B, ARG53C, ARG54B, ARG54C, ARG58B, ARG58C, ARG63B, ARG63C, ASN144B, ASN176B, ASN176C, ASN190B, ASN190C, ASN228B, ASN228C, ASP220B, ASP220C, GLN223B, GLN223C, GLN23B, GLN23C, GLN299B, GLN299C, GLN48B, GLN48C, GLU100B, GLU100C, GLU143B, GLU143C, GLU173B, GLU173C, GLU182B, GLU182C, GLU192B, GLU192C, GLU224B, GLU224C, GLU59B, GLU59C, GLU60B, GLU60C, GLY179B, GLY179C, GLY219B, GLY219C, HIS166B, HIS166C, ILE177B, ILE177C, ILE188B, ILE188C, ILE229B, ILE229C, LEU164B, LEU164C, LEU194B, LEU194C, LEU218B, LEU218C, LEU226B, LEU226C, LYS141B, LYS141C, LYS175B, LYS175C, LYS222B, LYS222C, LYS258B, LYS258C, LYS298B, LYS298C, PHE102B, PHE174B, PHE174C, PHE178B, PHE178C, PHE183B, PHE183C, PHE217B, PHE217C, PHE240B, PHE240C, PHE24B, PHE24C, PRO142B, PRO142C, PRO181B, PRO181C, PRO186B, PRO186C, PRO216B, PRO216C, SER215B, SER215C, SER49B, SER49C, SER52B, SER52C, SER57B, SER57C, THR180B, THR180C, THR221B, THR221C, THR225B, THR225C, THR230B, THR230C, TYR191B, TYR191C, TYR300B, TYR300C, VAL172B, VAL172C, VAL184B, VAL184C, VAL189B, VAL189C, VAL301B, VAL301C
• C-D: ARG286C, ARG286D, ARG31C, ARG31D, ASN75C, ASN75D, ASP125C, ASP125D, ASP149C, ASP149D, GLN122C, GLN122D, GLU114C, GLU114D, GLU115C, GLU115D, GLU32C, GLU32D, GLU38C, GLU38D, GLU94C, GLU94D, GLY36C, GLY36D, HIS156C, HIS156D, HIS73C, HIS73D, HIS74C, HIS74D, HIS80C, HIS80D, ILE120C, ILE120D, ILE123C, ILE123D, ILE152C, ILE152D, ILE154C, ILE154D, ILE157C, ILE157D, ILE275C, ILE275D, LEU124C, LEU124D, LEU148C, LEU148D, LEU270C, LEU270D, LEU37C, LEU37D, LEU72C, LEU72D, LEU95C, LEU95D, LYS121C, LYS121D, LYS29C, LYS33C, LYS33D, PHE119C, PHE119D, PHE12C, PHE12D, PRO153C, PRO153D, PRO155C, PRO155D, PRO277C, PRO277D, SER118C, SER118D, SER34C, SER34D, THR117C, THR117D, THR276C, THR276D, THR35C, THR35D, THR78C, THR78D, TYR129C, TYR129D, TYR39C, TYR39D
• D-G: ALA214D, ALA214G, ALA227D, ALA227G, ALA231D, ALA231G, ALA51D, ALA51G, ARG302D, ARG302G, ARG303D, ARG303G, ARG304D, ARG304G, ARG47D, ARG47G, ARG50D, ARG50G, ARG53D, ARG53G, ARG54D, ARG54G, ARG58D, ARG58G, ARG63D, ARG63G, ASN176D, ASN176G, ASN190D, ASN190G, ASN228D, ASN228G, ASP220D, ASP220G, GLN223D, GLN223G, GLN23D, GLN23G, GLN299D, GLN299G, GLN48D, GLN48G, GLU100D, GLU100G, GLU143D, GLU143G, GLU173D, GLU173G, GLU182D, GLU182G, GLU192D, GLU192G, GLU224D, GLU224G, GLU59D, GLU59G, GLU60D, GLU60G, GLY179D, GLY179G, GLY219D, GLY219G, GLY55G, HIS166D, HIS166G, ILE177D, ILE177G, ILE188D, ILE188G, ILE229D, ILE229G, LEU164D, LEU164G, LEU194D, LEU194G, LEU218D, LEU218G, LEU226D, LEU226G, LYS141D, LYS141G, LYS175D, LYS175G, LYS222D, LYS222G, LYS258D, LYS258G, LYS298D, LYS298G, LYS45G, LYS46G, PHE102D, PHE102G, PHE174D, PHE174G, PHE178D, PHE178G, PHE183D, PHE183G, PHE217D, PHE217G, PHE240D, PHE240G, PHE24D, PHE24G, PRO142D, PRO142G, PRO181D, PRO181G, PRO186D, PRO186G, PRO216D, PRO216G, SER215D, SER215G, SER305D, SER49D, SER49G, SER52D, SER52G, SER57D, SER57G, THR180D, THR180G, THR221D, THR221G, THR225D, THR225G, THR230D, THR230G, THR87G, TYR191D, TYR191G, TYR300D, TYR300G, VAL184D, VAL184G, VAL189D, VAL189G, VAL301D, VAL301G, VAL56G
• E-F: ARG286E, ARG286F, ARG31E, ARG31F, ASN75E, ASN75F, ASP125E, ASP125F, ASP149E, ASP149F, GLN122E, GLN122F, GLU114E, GLU114F, GLU115E, GLU115F, GLU32E, GLU32F, GLU38E, GLU38F, GLU94E, GLU94F, GLY126F, GLY36E, GLY36F, HIS156E, HIS156F, HIS73E, HIS73F, HIS74E, HIS74F, HIS80E, HIS80F, ILE120E, ILE120F, ILE123E, ILE123F, ILE152E, ILE152F, ILE154E, ILE154F, ILE157E, ILE157F, ILE275E, ILE275F, LEU124E, LEU124F, LEU148E, LEU148F, LEU270E, LEU270F, LEU37E, LEU37F, LEU72E, LEU72F, LEU95E, LEU95F, LYS121E, LYS121F, LYS158F, LYS33E, LYS33F, PHE119E, PHE119F, PHE12E, PHE12F, PRO153E, PRO153F, PRO155E, PRO155F, PRO277E, PRO277F, SER118E, SER118F, SER34E, SER34F, THR117E, THR117F, THR276E, THR276F, THR35E, THR35F, THR78E, THR78F, TYR129E, TYR129F, TYR39E, TYR39F, VAL71E, VAL71F
• F-H: ALA214F, ALA214H, ALA227F, ALA227H, ALA231F, ALA231H, ALA51F, ALA51H, ARG302F, ARG302H, ARG303F, ARG303H, ARG304F, ARG304H, ARG47F, ARG47H, ARG50F, ARG50H, ARG53F, ARG53H, ARG54F, ARG54H, ARG58F, ARG58H, ARG63F, ARG63H, ASN176F, ASN176H, ASN190F, ASN190H, ASN228F, ASN228H, ASP220F, ASP220H, GLN223F, GLN223H, GLN23F, GLN23H, GLN299F, GLN299H, GLN48F, GLN48H, GLU100F, GLU100H, GLU143F, GLU143H, GLU173F, GLU173H, GLU182F, GLU182H, GLU192F, GLU192H, GLU224F, GLU224H, GLU59F, GLU59H, GLU60F, GLU60H, GLY179F, GLY179H, GLY219F, GLY219H, GLY55F, HIS166F, HIS166H, ILE177F, ILE177H, ILE188F, ILE188H, ILE229F, ILE229H, LEU164F, LEU164H, LEU194F, LEU194H, LEU218F, LEU218H, LEU226F, LEU226H, LYS141F, LYS141H, LYS175F, LYS175H, LYS222F, LYS222H, LYS258F, LYS258H, LYS298F, LYS298H, PHE102F, PHE102H, PHE174F, PHE174H, PHE178F, PHE178H, PHE183F, PHE183H, PHE217F, PHE217H, PHE240F, PHE240H, PHE24F, PHE24H, PRO142F, PRO142H, PRO181F, PRO181H, PRO186F, PRO186H, PRO216F, PRO216H, SER215F, SER215H, SER305H, SER49F, SER49H, SER52F, SER52H, SER57F, SER57H, THR180F, THR180H, THR221F, THR221H, THR225F, THR225H, THR230F, THR230H, TYR191F, TYR191H, TYR300F, TYR300H, VAL172F, VAL184F, VAL184H, VAL189F, VAL189H, VAL301F, VAL301H, VAL56F