1ZYC

crystal structure of eif2alpha protein kinase gcn2: wild- type in apo form.

• Total interactions analyzed: 6
• Total true interactions: 5
• Strongest Interaction:
  • Chains: C-D
  • Int. Res.: 114
  • Norm. En. per Res.: -3.5899
• Hub Node: A(2)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-39.2299	19.7587	-345.266	-364.7372	109	20	8	13695	2	18	17
A-C	-7.724	-19.9539	-87.7998	-115.4777	45	13	0	3969	0	27	28
B-C	0.0	0.0	-0.0004	-0.0004	2	0	0	1	0	1	0
B-D	0.0	1.1771	-0.1215	1.0556	4	0	0	28	0	4	5
C-D	-82.0217	20.0245	-347.25	-409.2472	114	24	10	14298	2	17	18

Interface residues

• A-B: ALA596A, ALA596B, ALA619A, ALA648A, ALA648B, ALA660A, ALA660B, ALA661A, ALA661B, ARG594A, ARG594B, ARG623A, ARG623B, ARG657A, ARG657B, ARG768A, ARG768B, ARG769A, ARG769B, ASN618A, ASN651A, ASN651B, ASN770A, ASN770B, ASP598A, ASP598B, ASP621A, ASP621B, GLN787A, GLN787B, GLN829A, GLN829B, GLU634A, GLU634B, GLU635A, GLU643A, GLU643B, GLU664A, GLU664B, GLY830A, GLY830B, HIS652A, HIS652B, HIS827A, ILE640A, ILE640B, ILE786A, ILE786B, ILE826A, ILE826B, ILE831A, ILE831B, ILE832B, LEU593A, LEU593B, LEU620A, LEU620B, LEU637A, LEU637B, LEU641A, LEU641B, LEU646A, LEU646B, LEU647A, LEU647B, LEU650A, LEU650B, LEU663A, LEU663B, LEU784A, LEU784B, LYS780A, MET645A, MET645B, PHE599A, PHE599B, PHE785A, PHE785B, SER592A, SER592B, SER597A, SER597B, SER638A, SER638B, SER642A, SER642B, SER649A, SER649B, SER782A, SER782B, SER828A, SER828B, THR639A, THR639B, THR783A, THR783B, TRP662A, TRP662B, TYR595A, TYR595B, TYR625B, TYR658A, TYR658B, TYR659A, TYR659B, TYR825A, TYR825B, VAL644A, VAL644B
• A-C: ALA596A, ALA603A, ALA616A, ALA619A, ALA892C, ARG617A, ARG623A, ARG959C, ARG969C, ASN618A, ASN903C, ASN967C, ASP598A, ASP621A, ASP897C, ASP963C, ASP965C, GLU600A, GLU601A, GLU792A, GLU845A, GLU894C, GLY898C, GLY900C, HIS901C, HIS964C, ILE602A, ILE940C, LEU620A, LEU896C, LYS615A, LYS905C, LYS968C, PHE599A, PRO966C, SER597A, SER622A, SER939C, THR893C, THR899C, TYR624A, TYR790A, TYR902C, VAL895C, VAL938C
• B-C: ARG623B, HIS901C
• B-D: GLU635D, GLU845B, SER846B, THR633D
• C-D: ALA596C, ALA596D, ALA648C, ALA648D, ALA660C, ALA660D, ALA661C, ALA661D, ARG594C, ARG594D, ARG623C, ARG623D, ARG657C, ARG657D, ARG768C, ARG768D, ARG769C, ARG769D, ASN618C, ASN618D, ASN651C, ASN651D, ASN770C, ASN770D, ASP598C, ASP598D, ASP621C, ASP621D, GLN787C, GLN787D, GLN829C, GLN829D, GLU634C, GLU634D, GLU635C, GLU635D, GLU643C, GLU643D, GLU664C, GLU664D, GLU904D, GLY830C, GLY830D, HIS652C, HIS652D, HIS827C, HIS827D, ILE640C, ILE640D, ILE786C, ILE786D, ILE826C, ILE826D, ILE831C, ILE831D, ILE832D, LEU593C, LEU593D, LEU620C, LEU620D, LEU637C, LEU637D, LEU641C, LEU641D, LEU646C, LEU646D, LEU647C, LEU647D, LEU650C, LEU650D, LEU663C, LEU663D, LEU784C, LEU784D, MET645C, MET645D, MET788D, PHE599C, PHE599D, PHE771C, PHE785C, PHE785D, SER592C, SER592D, SER597C, SER597D, SER638C, SER638D, SER642C, SER642D, SER649C, SER649D, SER782C, SER782D, SER828C, SER828D, THR639C, THR639D, THR783C, THR783D, TRP662C, TRP662D, TYR595C, TYR595D, TYR625D, TYR658C, TYR658D, TYR659C, TYR659D, TYR825C, TYR825D, VAL644C, VAL644D, VAL772C