1ZY8

the crystal structure of dihydrolipoamide dehydrogenase and dihydrolipoamide dehydrogenase-binding protein (didomain) subcomplex of human pyruvate dehydrogenase complex.

• Total interactions analyzed: 105
• Total true interactions: 28
• Strongest Interaction:
  • Chains: B-K
  • Int. Res.: 51
  • Norm. En. per Res.: -3.7386
• Hub Node: A(4)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-104.4584	1.4047	-710.24	-813.2937	320	51	32	35333	0	105	118
A-E	0.0	0.0	-1.2964	-1.2964	5	0	0	66	0	4	3
A-F	-33.6251	4.4329	-127.156	-156.3482	84	5	1	6055	1	51	56
A-K	0.0	0.0	-80.9058	-80.9058	48	12	1	4375	0	18	17
B-H	0.0	-9.3452	-32.3059	-41.6511	25	2	0	1670	0	12	17
B-I	0.0	25.2671	188.937	214.2041	30	44	0	842	0	4	4
B-J	-19.2789	-6.7781	-126.532	-152.589	86	10	1	6201	2	55	57
B-K	-25.3789	-75.6068	-89.6816	-190.6673	51	7	1	3642	5	17	12
C-D	-95.8581	0.6744	-539.012	-634.1957	310	27	34	28623	0	108	117
C-E	-32.4802	-10.9788	-121.668	-165.1269	83	8	0	5901	1	53	53
C-G	0.0	0.0	-0.4313	-0.4313	6	0	0	78	0	4	4
C-L	0.0	0.0	-91.2637	-91.2637	47	6	1	4407	0	17	18
D-E	0.0	0.0	-0.9877	-0.9877	5	0	0	61	0	4	4
D-G	-17.3458	3.6917	-102.36	-116.0141	79	3	0	5083	0	53	53
D-L	-11.2454	0.0	-75.7352	-86.9806	48	4	0	3513	0	19	10
E-F	-177.8901	-31.3467	-785.077	-994.3138	336	75	30	42803	17	107	116
E-H	0.0	0.0	-0.0138	-0.0138	7	0	0	17	0	3	7
E-M	-29.4619	-28.2581	-124.143	-181.863	50	11	0	4657	1	18	18
F-G	0.0	0.0	-1.892	-1.892	20	0	0	223	0	7	14
F-M	-15.9871	-56.9808	-68.6499	-141.6178	51	27	1	3926	2	18	12
G-H	-80.2834	-7.4312	-709.018	-796.7326	325	30	34	34917	1	106	119
G-K	0.0	0.0	-0.1793	-0.1793	5	0	0	24	0	1	0
G-N	0.0	0.0	-98.8159	-98.8159	47	7	0	4659	0	19	16
H-K	0.0	-1.3663	-2.8059	-4.1723	9	0	0	206	0	4	6
H-N	-8.5025	-57.7979	-83.6325	-149.9329	50	6	1	3417	4	18	12
I-J	-194.9142	-60.998	-969.847	-1225.7592	342	62	34	43271	16	106	119
I-O	-13.9947	-38.8681	-89.2145	-142.0773	48	3	1	4072	2	15	16
J-O	-22.4	-52.9272	-84.9849	-160.3121	50	15	0	3626	2	18	10

Interface residues

• A-B: ALA21A, ALA21B, ALA22A, ALA25A, ALA25B, ALA26A, ALA26B, ALA328A, ALA328B, ALA331A, ALA331B, ALA346A, ALA346B, ALA365A, ALA365B, ALA389A, ALA389B, ALA390A, ALA390B, ALA394A, ALA394B, ALA398A, ALA398B, ALA425A, ALA425B, ALA432A, ALA432B, ALA433A, ALA433B, ALA435A, ALA435B, ALA440A, ALA440B, ALA446A, ALA446B, ALA451A, ALA451B, ALA458A, ALA458B, ALA465A, ALA55A, ALA55B, ALA66A, ALA66B, ALA72A, ALA72B, ALA95A, ALA95B, ALA98A, ALA98B, ARG393A, ARG393B, ARG447A, ARG447B, ARG460A, ARG460B, ARG74A, ARG74B, ARG82A, ARG82B, ASN110A, ASN110B, ASN352B, ASN391A, ASN391B, ASN397A, ASN397B, ASN430A, ASN430B, ASN473A, ASN473B, ASN58A, ASN58B, ASN59A, ASN59B, ASN84A, ASN84B, ASP333A, ASP333B, ASP350A, ASP350B, ASP399A, ASP399B, ASP444A, ASP444B, ASP70A, ASP70B, ASP86A, ASP86B, CYS353A, CYS353B, CYS449A, CYS449B, CYS45A, CYS45B, CYS50A, CYS50B, GLN109A, GLN109B, GLN27A, GLN27B, GLN91A, GLN91B, GLU192A, GLU332A, GLU332B, GLU334A, GLU340A, GLU340B, GLU363A, GLU363B, GLU427A, GLU427B, GLU431A, GLU431B, GLU437A, GLU437B, GLU443A, GLU443B, GLU457A, GLU457B, GLU461A, GLU461B, GLU77A, GLU77B, GLU80A, GLU80B, GLU90A, GLU90B, GLY102A, GLY102B, GLY29A, GLY29B, GLY345A, GLY345B, GLY424A, GLY424B, GLY426A, GLY426B, GLY439A, GLY439B, GLY469A, GLY469B, GLY49A, GLY49B, GLY75A, GLY75B, HIS105B, HIS329A, HIS329B, HIS348A, HIS348B, HIS361B, HIS450A, HIS450B, HIS452A, HIS452B, HIS61A, HIS61B, HIS64A, HIS64B, HIS67A, HIS67B, ILE103A, ILE103B, ILE23A, ILE23B, ILE336A, ILE336B, ILE337A, ILE337B, ILE349A, ILE349B, ILE358A, ILE445A, ILE445B, ILE472A, ILE472B, ILE51A, ILE51B, ILE76A, ILE76B, LEU106A, LEU106B, LEU200A, LEU28A, LEU28B, LEU327A, LEU327B, LEU434A, LEU434B, LEU436A, LEU436B, LEU455A, LEU455B, LEU464A, LEU464B, LEU46A, LEU46B, LEU56A, LEU56B, LEU57A, LEU57B, LEU83A, LEU83B, LEU85A, LEU85B, LEU99A, LEU99B, LYS111A, LYS111B, LYS24A, LYS24B, LYS330A, LYS330B, LYS395A, LYS395B, LYS470A, LYS470B, LYS54A, LYS54B, LYS69A, LYS69B, LYS87A, LYS87B, LYS92A, LYS92B, LYS97A, LYS97B, MET428A, MET428B, MET65A, MET65B, MET78A, MET78B, MET88A, MET88B, MET89A, MET89B, PHE386A, PHE386B, PHE388A, PHE388B, PHE459A, PHE459B, PHE468A, PHE468B, PHE474A, PHE474B, PHE71A, PHE71B, PRO16A, PRO16B, PRO325A, PRO355A, PRO355B, PRO423A, PRO423B, PRO453A, PRO453B, PRO52A, PRO52B, SER356A, SER356B, SER392A, SER392B, SER441A, SER441B, SER456A, SER456B, SER471A, SER471B, SER53A, SER53B, SER60A, SER60B, SER73A, SER73B, SER79A, SER79B, THR100B, THR360A, THR396A, THR396B, THR454A, THR454B, THR94A, THR94B, TRP366A, TRP366B, TYR19A, TYR19B, TYR351A, TYR351B, TYR359A, TYR359B, TYR438A, TYR438B, TYR62A, TYR62B, TYR63A, TYR63B, VAL20A, VAL20B, VAL347A, VAL347B, VAL354A, VAL354B, VAL357A, VAL357B, VAL367A, VAL367B, VAL429A, VAL429B, VAL448A, VAL448B, VAL81A, VAL81B, VAL96A, VAL96B
• A-E: GLU380A, GLU77E, GLY378A, GLY75E, LYS410A
• A-F: ALA202F, ALA246F, ALA266F, ALA317A, ALA323A, ARG299A, ARG301A, ARG307A, ARG82F, ASN305A, ASN352A, ASN84F, ASP251F, ASP255F, ASP297A, ASP350A, ASP86F, CYS338A, GLN309A, GLN373A, GLN409A, GLU179F, GLU295A, GLU334A, GLU371A, GLU372A, GLU376A, GLU377A, GLU380A, GLU80F, GLY201F, GLY245F, GLY252F, GLY319A, GLY324A, GLY378A, HIS348A, HIS67F, ILE269F, ILE302A, ILE318A, ILE349A, ILE379A, LEU200F, LEU296A, LEU374A, LEU83F, LEU85F, LYS175F, LYS176F, LYS248F, LYS249F, LYS253F, LYS311A, LYS330A, LYS369A, LYS375A, LYS382A, LYS410A, LYS87F, MET88F, PHE308A, PRO178F, PRO298A, PRO303A, PRO325A, SER250F, SER257F, SER411A, THR247F, THR270F, THR306A, THR412A, TRP197F, TYR351A, TYR381A, TYR63F, VAL177F, VAL268F, VAL304A, VAL322A, VAL347A, VAL383A, VAL81F
• A-K: ALA134K, ALA135K, ALA435A, ALA440A, ALA446A, ALA466A, ARG130K, ARG136K, ARG155K, ARG414A, ARG447A, ASN137K, ASP162K, ASP413A, ASP444A, CYS442A, CYS449A, GLN409A, GLU161K, GLU437A, GLU443A, GLY153K, GLY439A, ILE138K, ILE157K, ILE445A, LEU131K, LEU164K, LEU434A, LEU436A, LYS141K, LYS160K, LYS165K, LYS382A, PHE158K, PHE468A, PRO133K, PRO154K, SER132K, SER411A, SER441A, SER467A, THR152K, THR159K, THR412A, TYR438A, VAL415A, VAL448A
• B-H: ASN125B, ASN314B, ASP161H, ASP163H, ASP251H, GLY123B, GLY252H, GLY293B, ILE254H, ILE294B, ILE312B, ILE315B, LEU292B, LYS124B, LYS142B, LYS248H, LYS249H, LYS253H, LYS311B, PRO313B, SER250H, THR159H, THR164H, THR247H, THR310B
• B-I: ARG228I, ASN225I, ASP219I, GLN227I, GLU221I, GLU380B, GLU77I, GLY211I, GLY214I, GLY378B, GLY75I, HIS212I, HIS6I, ILE218I, ILE222I, ILE5B, LEU239I, LEU421I, LYS224I, LYS410B, MET220I, PHE226I, PHE7I, SER223I, TRP1B, TRP1I, TYR381B, VAL213I, VAL364I, VAL9B
• B-J: ALA202J, ALA246J, ALA266J, ALA317B, ALA323B, ARG299B, ARG301B, ARG307B, ARG82J, ASN305B, ASN84J, ASP251J, ASP255J, ASP297B, ASP350B, ASP86J, GLN309B, GLN373B, GLN409B, GLU179J, GLU295B, GLU334B, GLU376B, GLU377B, GLU380B, GLU80J, GLU90J, GLY201J, GLY245J, GLY252J, GLY324B, GLY378B, HIS348B, HIS67J, ILE254J, ILE269J, ILE302B, ILE318B, ILE337B, ILE349B, ILE379B, ILE5B, LEU200J, LEU296B, LEU374B, LEU416B, LEU83J, LEU85J, LYS175J, LYS176J, LYS248J, LYS249J, LYS253J, LYS311B, LYS330B, LYS369B, LYS375B, LYS410B, LYS87J, MET88J, PHE308B, PRO178J, PRO298B, PRO303B, PRO325B, SER250J, SER257J, SER411B, THR244J, THR247J, THR270J, THR306B, THR412B, TRP197J, TYR351B, TYR381B, TYR63J, TYR6J, VAL177J, VAL256J, VAL268J, VAL304B, VAL322B, VAL347B, VAL81J, VAL9B
• B-K: ALA134K, ALA135K, ALA343B, ALA346B, ALA433B, ALA435B, ALA440B, ARG130K, ARG136K, ARG155K, ARG307B, ARG414B, ASN137K, ASN352B, ASP350B, ASP413B, ASP444B, CYS353B, GLU140K, GLU340B, GLU437B, GLU443B, GLY341B, GLY344B, GLY345B, GLY439B, HIS142K, HIS348B, ILE138K, ILE157K, ILE337B, ILE349B, ILE445B, LEU131K, LEU139K, LEU434B, LEU436B, LYS141K, LYS160K, PHE158K, PRO133K, PRO154K, SER132K, SER143K, SER441B, THR159K, THR306B, THR412B, TYR351B, TYR438B, VAL347B
• C-D: ALA21C, ALA21D, ALA25C, ALA26C, ALA26D, ALA328C, ALA328D, ALA331C, ALA331D, ALA346C, ALA346D, ALA365C, ALA365D, ALA389C, ALA389D, ALA390C, ALA390D, ALA394C, ALA394D, ALA398C, ALA398D, ALA425C, ALA425D, ALA432C, ALA432D, ALA433C, ALA433D, ALA435C, ALA435D, ALA440C, ALA440D, ALA446C, ALA446D, ALA451C, ALA451D, ALA458C, ALA458D, ALA55C, ALA55D, ALA66C, ALA66D, ALA72C, ALA72D, ALA95C, ALA95D, ALA98C, ALA98D, ARG393C, ARG393D, ARG414D, ARG447C, ARG447D, ARG460C, ARG460D, ARG74C, ARG74D, ARG82C, ARG82D, ASN110C, ASN110D, ASN391C, ASN391D, ASN397C, ASN397D, ASN430C, ASN430D, ASN473C, ASN473D, ASN58C, ASN58D, ASN59C, ASN59D, ASN84C, ASN84D, ASP333C, ASP333D, ASP350C, ASP350D, ASP399C, ASP399D, ASP444C, ASP444D, ASP70C, ASP70D, ASP86C, ASP86D, CYS353C, CYS353D, CYS449C, CYS449D, CYS45C, CYS45D, CYS50C, CYS50D, GLN109C, GLN109D, GLN27C, GLN27D, GLN91C, GLN91D, GLU332C, GLU332D, GLU334C, GLU334D, GLU340C, GLU340D, GLU363C, GLU363D, GLU427C, GLU427D, GLU431C, GLU431D, GLU437C, GLU437D, GLU443C, GLU443D, GLU457C, GLU457D, GLU461C, GLU461D, GLU77C, GLU77D, GLU80C, GLU80D, GLU90C, GLU90D, GLY102C, GLY102D, GLY29C, GLY29D, GLY345C, GLY345D, GLY424C, GLY424D, GLY426C, GLY426D, GLY439C, GLY439D, GLY469C, GLY469D, GLY49C, GLY75C, GLY75D, HIS105C, HIS105D, HIS329C, HIS329D, HIS348C, HIS348D, HIS361D, HIS450C, HIS450D, HIS452C, HIS452D, HIS61C, HIS61D, HIS64C, HIS64D, HIS67C, HIS67D, ILE103C, ILE103D, ILE23C, ILE23D, ILE336C, ILE336D, ILE337C, ILE337D, ILE349C, ILE349D, ILE445C, ILE445D, ILE472C, ILE472D, ILE51C, ILE51D, ILE76C, ILE76D, LEU106C, LEU106D, LEU28C, LEU28D, LEU327C, LEU327D, LEU434C, LEU434D, LEU436C, LEU436D, LEU455C, LEU455D, LEU464C, LEU464D, LEU46C, LEU46D, LEU56C, LEU56D, LEU57C, LEU57D, LEU83C, LEU83D, LEU85C, LEU85D, LEU99C, LEU99D, LYS111D, LYS24C, LYS24D, LYS330C, LYS330D, LYS395C, LYS395D, LYS470C, LYS470D, LYS54C, LYS54D, LYS69C, LYS69D, LYS87C, LYS87D, LYS92C, LYS92D, LYS97C, LYS97D, MET428C, MET428D, MET65C, MET65D, MET78C, MET78D, MET88C, MET88D, MET89C, MET89D, PHE459C, PHE459D, PHE468C, PHE468D, PHE474C, PHE474D, PHE71C, PHE71D, PRO16C, PRO16D, PRO355C, PRO355D, PRO423C, PRO423D, PRO453C, PRO453D, PRO52C, PRO52D, SER356C, SER356D, SER392C, SER392D, SER441C, SER441D, SER456C, SER456D, SER467C, SER467D, SER471C, SER471D, SER53C, SER53D, SER60C, SER60D, SER73C, SER73D, SER79C, SER79D, THR100C, THR100D, THR396C, THR396D, THR454C, THR454D, THR94C, THR94D, TRP366C, TRP366D, TYR19C, TYR19D, TYR351C, TYR351D, TYR359C, TYR359D, TYR438C, TYR438D, TYR62C, TYR62D, TYR63C, TYR63D, VAL20C, VAL20D, VAL347C, VAL354C, VAL354D, VAL357C, VAL357D, VAL367C, VAL367D, VAL429C, VAL429D, VAL448C, VAL448D, VAL81C, VAL81D, VAL96C, VAL96D
• C-E: ALA202C, ALA266C, ALA317E, ALA323E, ARG299E, ARG301E, ARG307E, ARG82C, ASN305E, ASN352E, ASN84C, ASP251C, ASP255C, ASP297E, ASP350E, ASP86C, CYS338E, GLN309E, GLN373E, GLN409E, GLU179C, GLU267C, GLU295E, GLU334E, GLU371E, GLU372E, GLU376E, GLU377E, GLU380E, GLU80C, GLY201C, GLY252C, GLY319E, GLY324E, GLY378E, HIS348E, ILE269C, ILE302E, ILE318E, ILE337E, ILE349E, ILE379E, LEU174C, LEU200C, LEU296E, LEU374E, LEU83C, LEU85C, LYS175C, LYS176C, LYS248C, LYS249C, LYS253C, LYS311E, LYS330E, LYS369E, LYS375E, LYS382E, LYS410E, LYS87C, MET88C, PHE308E, PRO178C, PRO298E, PRO303E, PRO325E, SER250C, SER257C, SER411E, THR247C, THR270C, THR306E, THR412E, TYR351E, TYR381E, TYR63C, VAL177C, VAL268C, VAL304E, VAL322E, VAL347E, VAL383E, VAL81C
• C-G: GLU380G, GLU77C, GLY378G, GLY75C, LYS410G, TYR381G
• C-L: ALA134L, ALA135L, ALA163L, ALA435C, ALA440C, ALA446C, ARG130L, ARG136L, ARG155L, ARG414C, ARG447C, ASN137L, ASP162L, ASP413C, ASP444C, CYS442C, CYS449C, GLN409C, GLU161L, GLU437C, GLU443C, GLY153L, GLY156L, GLY439C, ILE138L, ILE157L, ILE445C, LEU131L, LEU164L, LEU436C, LYS141L, LYS160L, LYS165L, LYS382C, PHE158L, PHE468C, PRO133L, PRO154L, SER132L, SER411C, SER441C, SER467C, THR159L, THR412C, TYR438C, VAL415C, VAL448C
• D-E: GLU380E, GLU77D, GLY378E, GLY75D, LYS410E
• D-G: ALA202D, ALA266D, ALA317G, ALA323G, ARG299G, ARG301G, ARG307G, ARG82D, ASN305G, ASN352G, ASN84D, ASP251D, ASP255D, ASP297G, ASP350G, ASP86D, GLN309G, GLN373G, GLN409G, GLU179D, GLU267D, GLU295G, GLU334G, GLU371G, GLU372G, GLU376G, GLU377G, GLU380G, GLU80D, GLY201D, GLY252D, GLY324G, GLY378G, HIS348G, ILE269D, ILE302G, ILE318G, ILE349G, ILE379G, LEU200D, LEU296G, LEU374G, LEU83D, LEU85D, LYS175D, LYS176D, LYS180D, LYS248D, LYS249D, LYS253D, LYS311G, LYS330G, LYS369G, LYS375G, LYS410G, LYS87D, MET88D, PHE308G, PRO178D, PRO298G, PRO303G, PRO325G, SER250D, SER257D, SER411G, THR247D, THR270D, THR306G, THR310G, THR412G, TYR351G, TYR381G, TYR63D, VAL177D, VAL268D, VAL304G, VAL322G, VAL347G, VAL81D
• D-L: ALA134L, ALA135L, ALA343D, ALA346D, ALA433D, ALA435D, ALA440D, ARG130L, ARG136L, ARG155L, ARG307D, ARG414D, ARG447D, ASN137L, ASP350D, ASP444D, CYS353D, GLU140L, GLU340D, GLU437D, GLU443D, GLY341D, GLY344D, GLY345D, GLY439D, HIS142L, HIS348D, ILE138L, ILE157L, ILE337D, ILE349D, ILE445D, LEU131L, LEU139L, LEU434D, LEU436D, LYS141L, LYS160L, PRO133L, PRO154L, SER132L, SER143L, SER441D, THR159L, THR306D, TYR438D, VAL347D, VAL415D
• E-F: ALA21E, ALA21F, ALA22E, ALA22F, ALA25E, ALA25F, ALA26E, ALA26F, ALA328E, ALA328F, ALA331E, ALA331F, ALA346E, ALA346F, ALA365E, ALA365F, ALA389E, ALA389F, ALA390E, ALA390F, ALA394E, ALA394F, ALA398E, ALA398F, ALA425E, ALA425F, ALA432E, ALA432F, ALA433E, ALA433F, ALA435E, ALA435F, ALA440E, ALA440F, ALA446E, ALA446F, ALA451E, ALA451F, ALA458E, ALA458F, ALA465E, ALA55E, ALA55F, ALA66E, ALA66F, ALA72E, ALA72F, ALA95E, ALA95F, ALA98E, ALA98F, ARG393E, ARG393F, ARG447E, ARG447F, ARG460E, ARG460F, ARG74E, ARG74F, ARG82E, ARG82F, ASN110E, ASN110F, ASN391E, ASN391F, ASN397E, ASN397F, ASN430E, ASN430F, ASN463F, ASN473E, ASN473F, ASN58E, ASN58F, ASN59E, ASN59F, ASN84E, ASN84F, ASP333E, ASP333F, ASP350E, ASP350F, ASP399E, ASP399F, ASP444E, ASP444F, ASP70E, ASP70F, ASP86E, ASP86F, CYS353E, CYS353F, CYS442E, CYS449E, CYS449F, CYS45E, CYS45F, CYS50E, CYS50F, GLN109E, GLN109F, GLN27E, GLN27F, GLN91E, GLN91F, GLU332E, GLU332F, GLU334F, GLU340E, GLU340F, GLU363E, GLU363F, GLU427E, GLU427F, GLU431E, GLU431F, GLU437E, GLU437F, GLU443E, GLU443F, GLU457E, GLU457F, GLU461E, GLU461F, GLU77E, GLU77F, GLU80E, GLU80F, GLU90E, GLU90F, GLY101F, GLY102E, GLY102F, GLY17F, GLY29E, GLY29F, GLY345E, GLY345F, GLY424E, GLY424F, GLY426E, GLY426F, GLY439E, GLY439F, GLY469E, GLY469F, GLY49E, GLY75E, GLY75F, HIS105E, HIS105F, HIS329E, HIS329F, HIS348E, HIS348F, HIS361E, HIS361F, HIS450E, HIS450F, HIS452E, HIS452F, HIS61E, HIS61F, HIS64E, HIS64F, HIS67E, HIS67F, HIS6E, ILE103E, ILE103F, ILE23E, ILE23F, ILE336E, ILE336F, ILE337E, ILE337F, ILE349E, ILE349F, ILE358F, ILE445E, ILE445F, ILE472E, ILE472F, ILE51E, ILE51F, ILE5F, ILE76E, ILE76F, LEU106E, LEU106F, LEU200E, LEU200F, LEU28E, LEU28F, LEU327E, LEU327F, LEU434E, LEU434F, LEU436E, LEU436F, LEU455E, LEU455F, LEU464E, LEU464F, LEU46E, LEU46F, LEU56E, LEU56F, LEU57E, LEU57F, LEU83E, LEU83F, LEU85E, LEU85F, LEU99E, LEU99F, LYS111E, LYS24E, LYS24F, LYS330E, LYS330F, LYS395E, LYS395F, LYS470E, LYS470F, LYS54E, LYS54F, LYS69E, LYS69F, LYS87E, LYS87F, LYS92E, LYS92F, LYS97E, LYS97F, MET428E, MET428F, MET65E, MET65F, MET78E, MET78F, MET88E, MET88F, MET89E, MET89F, PHE107E, PHE107F, PHE386E, PHE386F, PHE388E, PHE388F, PHE459E, PHE459F, PHE468E, PHE468F, PHE474E, PHE474F, PHE71E, PHE71F, PRO16E, PRO16F, PRO355E, PRO355F, PRO423E, PRO423F, PRO453E, PRO453F, PRO52E, PRO52F, SER356E, SER356F, SER392E, SER392F, SER441E, SER441F, SER456E, SER456F, SER471E, SER471F, SER53E, SER53F, SER60E, SER60F, SER73E, SER73F, SER79E, SER79F, THR100E, THR100F, THR360E, THR360F, THR396E, THR396F, THR400E, THR400F, THR454E, THR454F, THR94E, THR94F, TRP366E, TRP366F, TYR19E, TYR19F, TYR351E, TYR351F, TYR359E, TYR359F, TYR438E, TYR438F, TYR62E, TYR62F, TYR63E, TYR63F, TYR6F, VAL112F, VAL20E, VAL20F, VAL347E, VAL347F, VAL354E, VAL354F, VAL357E, VAL357F, VAL367E, VAL367F, VAL415E, VAL415F, VAL429E, VAL429F, VAL448E, VAL448F, VAL81E, VAL81F, VAL96E, VAL96F, VAL9F
• E-H: GLN231E, GLN3H, LYS108H, LYS111H, LYS236E, LYS238E, THR270E
• E-M: ALA134M, ALA135M, ALA163M, ALA435E, ALA440E, ALA446E, ARG130M, ARG136M, ARG155M, ARG414E, ARG447E, ASN137M, ASP162M, ASP413E, ASP444E, CYS442E, CYS449E, GLN409E, GLU161M, GLU437E, GLU443E, GLY153M, GLY156M, GLY439E, HIS348E, ILE138M, ILE157M, ILE445E, LEU131M, LEU139M, LEU164M, LEU434E, LEU436E, LYS141M, LYS160M, LYS382E, PHE158M, PHE468E, PRO133M, PRO154M, SER132M, SER411E, SER441E, SER467E, THR152M, THR159M, THR412E, TYR438E, VAL415E, VAL448E
• F-G: ASP251G, ASP6F, GLN231G, GLN3F, GLU179G, GLU267G, GLY234G, GLY29F, LYS108F, LYS111F, LYS232G, LYS236G, LYS238G, LYS253G, LYS265G, LYS31F, PHE237G, PRO4F, THR270G, VAL268G
• F-M: ALA134M, ALA135M, ALA343F, ALA346F, ALA433F, ALA435F, ALA440F, ARG130M, ARG136M, ARG155M, ARG307F, ARG414F, ARG447F, ASN137M, ASP350F, ASP444F, CYS353F, CYS442F, GLU140M, GLU340F, GLU437F, GLU443F, GLY341F, GLY344F, GLY345F, GLY439F, HIS142M, HIS348F, ILE138M, ILE157M, ILE337F, ILE349F, ILE445F, LEU131M, LEU139M, LEU28F, LEU434F, LEU436F, LYS141M, LYS160M, PHE158M, PRO133M, SER132M, SER143M, SER441F, THR159M, THR306F, TYR351F, TYR438F, VAL347F, VAL415F
• G-H: ALA21G, ALA21H, ALA22G, ALA22H, ALA25G, ALA25H, ALA26G, ALA26H, ALA328G, ALA328H, ALA331G, ALA331H, ALA346G, ALA346H, ALA365G, ALA365H, ALA389G, ALA389H, ALA390G, ALA390H, ALA394G, ALA394H, ALA398G, ALA398H, ALA425G, ALA425H, ALA432G, ALA432H, ALA433G, ALA433H, ALA435G, ALA435H, ALA440G, ALA440H, ALA446G, ALA446H, ALA451G, ALA451H, ALA458G, ALA458H, ALA465G, ALA55G, ALA55H, ALA66G, ALA66H, ALA72G, ALA72H, ALA95G, ALA95H, ALA98G, ALA98H, ARG393G, ARG393H, ARG414H, ARG447G, ARG447H, ARG460G, ARG460H, ARG74G, ARG74H, ARG82G, ARG82H, ASN110G, ASN110H, ASN391G, ASN391H, ASN397G, ASN397H, ASN430G, ASN430H, ASN463G, ASN473G, ASN473H, ASN58G, ASN58H, ASN59G, ASN59H, ASN84G, ASN84H, ASP333G, ASP333H, ASP350G, ASP350H, ASP399G, ASP399H, ASP444G, ASP444H, ASP70G, ASP70H, ASP86G, ASP86H, CYS353G, CYS353H, CYS449G, CYS449H, CYS45G, CYS45H, CYS50G, CYS50H, GLN109G, GLN109H, GLN27G, GLN27H, GLN91G, GLN91H, GLU192G, GLU192H, GLU332G, GLU332H, GLU334G, GLU334H, GLU340G, GLU340H, GLU363G, GLU363H, GLU427G, GLU427H, GLU431G, GLU431H, GLU437G, GLU437H, GLU443G, GLU443H, GLU457G, GLU457H, GLU461G, GLU461H, GLU77G, GLU77H, GLU80G, GLU80H, GLU90G, GLU90H, GLY102G, GLY102H, GLY29G, GLY29H, GLY345G, GLY345H, GLY424G, GLY424H, GLY426G, GLY426H, GLY439G, GLY439H, GLY469G, GLY469H, GLY49G, GLY75G, GLY75H, HIS105H, HIS329G, HIS329H, HIS348G, HIS348H, HIS361H, HIS450G, HIS450H, HIS452G, HIS452H, HIS61G, HIS61H, HIS64G, HIS64H, HIS67G, HIS67H, ILE103G, ILE103H, ILE23G, ILE23H, ILE336G, ILE336H, ILE337G, ILE337H, ILE349G, ILE349H, ILE358G, ILE445G, ILE445H, ILE472G, ILE472H, ILE51G, ILE51H, ILE76G, ILE76H, LEU106G, LEU106H, LEU200H, LEU28G, LEU28H, LEU327G, LEU327H, LEU434G, LEU434H, LEU436G, LEU436H, LEU455G, LEU455H, LEU464G, LEU464H, LEU46G, LEU46H, LEU56G, LEU56H, LEU57G, LEU57H, LEU83G, LEU83H, LEU85G, LEU85H, LEU99G, LEU99H, LYS111G, LYS111H, LYS24G, LYS24H, LYS330G, LYS330H, LYS395G, LYS395H, LYS470G, LYS470H, LYS54G, LYS54H, LYS69G, LYS87G, LYS87H, LYS92G, LYS92H, LYS97G, LYS97H, MET428G, MET428H, MET65G, MET65H, MET78G, MET78H, MET88G, MET88H, MET89G, MET89H, PHE107H, PHE386G, PHE388G, PHE388H, PHE459G, PHE459H, PHE468G, PHE468H, PHE474G, PHE474H, PHE71G, PHE71H, PRO16G, PRO16H, PRO325G, PRO355G, PRO355H, PRO423G, PRO423H, PRO453G, PRO453H, PRO52G, PRO52H, SER356G, SER356H, SER392G, SER392H, SER441G, SER441H, SER456G, SER456H, SER467G, SER471G, SER471H, SER53G, SER53H, SER60G, SER60H, SER73G, SER73H, SER79G, SER79H, THR100G, THR100H, THR360G, THR396G, THR396H, THR454G, THR454H, THR94G, THR94H, TRP366G, TRP366H, TYR19G, TYR19H, TYR351G, TYR351H, TYR359G, TYR359H, TYR438G, TYR438H, TYR62G, TYR62H, TYR63G, TYR63H, VAL20G, VAL20H, VAL347G, VAL347H, VAL354G, VAL354H, VAL357G, VAL357H, VAL367G, VAL367H, VAL415H, VAL429G, VAL429H, VAL448G, VAL448H, VAL81G, VAL81H, VAL96G, VAL96H
• G-K: ALA72G, GLU77G, GLY173K, LYS69G, SER73G
• G-N: ALA134N, ALA135N, ALA163N, ALA435G, ALA440G, ALA446G, ARG136N, ARG155N, ARG414G, ARG447G, ASN137N, ASP350G, ASP413G, ASP444G, CYS353G, CYS442G, CYS449G, GLN409G, GLU161N, GLU437G, GLU443G, GLY153N, GLY439G, HIS348G, ILE138N, ILE157N, ILE445G, LEU131N, LEU164N, LEU434G, LEU436G, LYS141N, LYS160N, LYS382G, PHE158N, PHE468G, PRO133N, PRO154N, SER132N, SER411G, SER441G, SER467G, THR152N, THR159N, THR412G, TYR438G, VAL448G
• H-K: ASN84H, ASP86H, GLN171K, GLU90H, GLY173K, LEU169K, LYS170K, LYS87H, THR172K
• H-N: ALA134N, ALA135N, ALA343H, ALA346H, ALA433H, ALA435H, ALA440H, ARG130N, ARG136N, ARG155N, ARG307H, ARG414H, ASN137N, ASP333H, ASP350H, ASP444H, CYS353H, GLU140N, GLU340H, GLU437H, GLU443H, GLY156N, GLY341H, GLY344H, GLY345H, GLY439H, HIS142N, HIS348H, ILE138N, ILE157N, ILE337H, ILE349H, ILE445H, LEU131N, LEU139N, LEU434H, LEU436H, LYS141N, LYS160N, PHE158N, PRO133N, PRO154N, SER132N, SER143N, SER441H, THR159N, THR306H, TYR438H, VAL347H, VAL415H
• I-J: ALA21I, ALA21J, ALA22I, ALA22J, ALA25I, ALA25J, ALA26I, ALA26J, ALA328I, ALA328J, ALA331I, ALA331J, ALA343I, ALA346I, ALA346J, ALA365I, ALA365J, ALA389I, ALA389J, ALA390I, ALA390J, ALA394I, ALA394J, ALA398I, ALA398J, ALA425I, ALA425J, ALA432I, ALA432J, ALA433I, ALA433J, ALA435I, ALA435J, ALA440I, ALA440J, ALA446I, ALA446J, ALA451I, ALA451J, ALA458I, ALA458J, ALA465I, ALA55I, ALA55J, ALA66I, ALA66J, ALA72I, ALA72J, ALA95I, ALA95J, ALA98I, ALA98J, ARG393I, ARG393J, ARG447I, ARG447J, ARG460I, ARG460J, ARG74I, ARG74J, ARG82I, ARG82J, ASN110I, ASN110J, ASN391I, ASN391J, ASN397I, ASN397J, ASN430I, ASN430J, ASN463I, ASN463J, ASN473I, ASN473J, ASN58I, ASN58J, ASN59I, ASN59J, ASN84I, ASN84J, ASP333I, ASP333J, ASP350I, ASP350J, ASP399I, ASP399J, ASP444I, ASP444J, ASP70I, ASP70J, ASP86I, ASP86J, CYS353I, CYS353J, CYS449I, CYS449J, CYS45I, CYS45J, CYS50I, CYS50J, GLN109I, GLN109J, GLN27I, GLN27J, GLN91I, GLN91J, GLU192J, GLU332I, GLU332J, GLU334I, GLU334J, GLU340I, GLU340J, GLU363I, GLU363J, GLU427I, GLU427J, GLU431I, GLU431J, GLU437I, GLU437J, GLU443I, GLU443J, GLU457I, GLU457J, GLU461I, GLU461J, GLU77I, GLU77J, GLU80I, GLU80J, GLU90I, GLU90J, GLY102I, GLY102J, GLY17J, GLY263I, GLY29J, GLY341J, GLY345I, GLY345J, GLY424I, GLY424J, GLY426I, GLY426J, GLY42J, GLY439I, GLY439J, GLY469I, GLY469J, GLY49I, GLY49J, GLY75I, GLY75J, HIS105I, HIS105J, HIS329I, HIS329J, HIS348I, HIS348J, HIS361I, HIS361J, HIS450I, HIS450J, HIS452I, HIS452J, HIS61I, HIS61J, HIS64I, HIS64J, HIS67I, HIS67J, HIS6I, ILE103I, ILE103J, ILE23I, ILE23J, ILE336I, ILE336J, ILE337I, ILE337J, ILE349I, ILE349J, ILE445I, ILE445J, ILE472I, ILE472J, ILE51I, ILE51J, ILE76I, ILE76J, LEU106I, LEU106J, LEU200I, LEU200J, LEU28I, LEU28J, LEU327I, LEU327J, LEU434I, LEU434J, LEU436I, LEU436J, LEU455I, LEU455J, LEU464I, LEU464J, LEU46I, LEU46J, LEU56I, LEU56J, LEU57I, LEU57J, LEU83I, LEU83J, LEU85I, LEU85J, LEU99I, LEU99J, LYS111J, LYS24I, LYS24J, LYS330I, LYS330J, LYS395I, LYS395J, LYS470I, LYS470J, LYS54I, LYS54J, LYS69I, LYS69J, LYS87I, LYS87J, LYS92I, LYS92J, LYS97I, LYS97J, MET428I, MET428J, MET65I, MET65J, MET78I, MET78J, MET88I, MET88J, MET89I, MET89J, PHE107I, PHE107J, PHE386I, PHE386J, PHE388I, PHE388J, PHE459I, PHE459J, PHE468I, PHE468J, PHE474I, PHE474J, PHE71I, PHE71J, PHE7I, PRO16I, PRO16J, PRO355I, PRO355J, PRO423I, PRO423J, PRO453I, PRO453J, PRO52I, PRO52J, SER262I, SER356I, SER356J, SER392I, SER392J, SER441I, SER441J, SER456I, SER456J, SER467I, SER467J, SER471I, SER471J, SER53I, SER53J, SER60I, SER60J, SER73I, SER73J, SER79I, SER79J, THR100I, THR100J, THR360I, THR360J, THR396I, THR396J, THR400I, THR400J, THR454I, THR454J, THR94I, THR94J, TRP1J, TRP366I, TRP366J, TYR19I, TYR19J, TYR351I, TYR351J, TYR359I, TYR359J, TYR438I, TYR438J, TYR62I, TYR62J, TYR63I, TYR63J, TYR6J, VAL20I, VAL20J, VAL339I, VAL347I, VAL347J, VAL354I, VAL354J, VAL357I, VAL357J, VAL367I, VAL367J, VAL415J, VAL429I, VAL429J, VAL448I, VAL448J, VAL81I, VAL81J, VAL96I, VAL96J
• I-O: ALA134O, ALA135O, ALA435I, ALA440I, ALA446I, ALA466I, ARG130O, ARG136O, ARG155O, ARG414I, ARG447I, ASN137O, ASP413I, ASP444I, CYS442I, CYS449I, GLN409I, GLU161O, GLU437I, GLU443I, GLY153O, GLY156O, GLY439I, HIS348I, ILE138O, ILE157O, ILE445I, LEU131O, LEU164O, LEU434I, LEU436I, LYS141O, LYS160O, LYS382I, PHE158O, PHE468I, PRO133O, PRO154O, SER132O, SER411I, SER441I, SER467I, THR152O, THR159O, THR412I, TYR438I, VAL415I, VAL448I
• J-O: ALA134O, ALA135O, ALA343J, ALA346J, ALA433J, ALA435J, ALA440J, ARG130O, ARG136O, ARG155O, ARG307J, ARG414J, ARG447J, ASN137O, ASP350J, ASP444J, CYS353J, GLU140O, GLU340J, GLU437J, GLU443J, GLY341J, GLY344J, GLY345J, GLY439J, HIS142O, HIS348J, ILE138O, ILE157O, ILE337J, ILE349J, ILE445J, LEU131O, LEU139O, LEU434J, LEU436J, LYS141O, LYS160O, PHE158O, PRO133O, PRO154O, SER132O, SER143O, SER441J, THR159O, THR306J, THR412J, TYR438J, VAL347J, VAL415J