1ZXE

crystal structure of eif2alpha protein kinase gcn2: d835n inactivating mutant in apo form

• Total interactions analyzed: 15
• Total true interactions: 9
• Strongest Interaction:
  • Chains: A-E
  • Int. Res.: 51
  • Norm. En. per Res.: -4.2099
• Hub Node: A(4)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-38.3796	14.9231	-300.818	-324.2745	114	11	9	12462	4	18	21
A-C	0.0	0.0	-9.9735	-9.9735	16	0	2	647	0	6	4
A-E	-22.6038	-73.9249	-118.176	-214.7046	51	7	0	4539	5	39	38
A-F	0.0	0.0	-0.1338	-0.1338	7	0	0	50	0	3	1
B-C	-8.9307	25.4118	-46.6907	-30.2096	44	9	0	2334	0	35	24
B-D	0.0	0.0	-0.0016	-0.0016	2	0	0	1	0	2	2
B-F	0.0	0.0	-0.0275	-0.0275	2	0	0	5	0	3	1
C-D	-27.8493	-32.1014	-316.38	-376.3307	116	12	8	12673	5	18	23
E-F	-34.71	-41.0178	-291.386	-367.1137	111	14	8	11876	5	19	21

Interface residues

• A-B: ALA596A, ALA596B, ALA619A, ALA648A, ALA648B, ALA660A, ALA660B, ALA661A, ALA661B, ARG594A, ARG594B, ARG623A, ARG623B, ARG657A, ARG657B, ARG768A, ARG768B, ARG769A, ARG769B, ASN618A, ASN618B, ASN651A, ASN651B, ASN770A, ASN770B, ASN903B, ASP598A, ASP598B, ASP621A, ASP621B, GLN787A, GLN787B, GLN829A, GLN829B, GLU634A, GLU634B, GLU635A, GLU635B, GLU643A, GLU643B, GLU664A, GLU664B, GLU904B, GLY830A, GLY830B, HIS652A, HIS652B, HIS827A, HIS827B, ILE640A, ILE640B, ILE826A, ILE826B, ILE831A, ILE831B, ILE832A, ILE832B, LEU593A, LEU593B, LEU620A, LEU620B, LEU637A, LEU637B, LEU641A, LEU641B, LEU646A, LEU646B, LEU647A, LEU647B, LEU650A, LEU650B, LEU663A, LEU663B, LEU784A, LEU784B, LYS858A, PHE599A, PHE599B, PHE771A, PHE785A, PHE785B, SER592A, SER592B, SER597A, SER597B, SER638A, SER638B, SER642A, SER642B, SER649A, SER649B, SER782A, SER782B, SER828A, SER828B, THR639A, THR639B, THR783A, THR783B, TRP662A, TRP662B, TYR595A, TYR595B, TYR625A, TYR625B, TYR658A, TYR658B, TYR659A, TYR659B, TYR825A, TYR825B, VAL644A, VAL644B, VAL772A
• A-C: ALA619A, ARG617A, ARG959C, ASN618A, ASP598A, ASP621A, GLU941C, HIS964C, ILE940C, LEU620A, LYS934C, SER597A, SER622A, SER937C, SER939C, VAL938C
• A-E: ALA603E, ALA616E, ALA619E, ALA892A, ARG617E, ARG623E, ARG794E, ARG936A, ARG959A, ARG969A, ASN618E, ASN793E, ASN903A, ASN967A, ASP621E, ASP844E, ASP897A, ASP963A, ASP965A, CYS791E, GLU600E, GLU601E, GLU789E, GLU792E, GLU845E, GLU894A, GLY900A, HIS901A, HIS964A, ILE602E, ILE906A, ILE940A, LEU605E, LEU620E, LEU896A, LEU960A, LYS615E, LYS905A, LYS968A, PRO966A, SER622E, SER937A, SER939A, THR893A, TYR624E, TYR625E, TYR790E, TYR902A, TYR909A, VAL895A, VAL938A
• A-F: ARG623F, ASN967A, ASP621F, ASP965A, HIS901A, LEU620F, LYS968A
• B-C: ARG623B, ARG794B, ARG814B, ARG817B, ARG847B, ARG959C, ASN651B, ASN848B, ASN903C, ASN967C, ASP810B, ASP844B, ASP897C, ASP963C, ASP965C, GLN653B, GLN818B, GLU792B, GLU811B, GLU821B, GLU845B, GLU894C, GLY898C, GLY900C, HIS901C, ILE843B, LEU815B, LEU896C, LYS850B, LYS905C, LYS968C, LYS984B, PRO966C, PRO982B, SER622B, SER846B, THR899C, TRP813B, TYR624B, TYR654B, TYR902C, VAL849B, VAL938C, VAL983B
• B-D: GLN807B, GLU635D
• B-F: GLU635B, SER846F
• C-D: ALA596C, ALA596D, ALA619C, ALA619D, ALA648C, ALA648D, ALA660C, ALA660D, ALA661C, ALA661D, ARG594C, ARG594D, ARG623C, ARG623D, ARG657C, ARG657D, ARG768C, ARG768D, ARG769C, ARG769D, ASN618C, ASN618D, ASN651C, ASN651D, ASN770C, ASN770D, ASP598C, ASP598D, ASP621C, ASP621D, GLN787C, GLN787D, GLN829C, GLN829D, GLU634C, GLU634D, GLU635C, GLU635D, GLU643C, GLU643D, GLU664C, GLU664D, GLU904C, GLU904D, GLY830C, GLY830D, HIS652C, HIS652D, HIS827C, HIS827D, ILE640C, ILE640D, ILE826C, ILE826D, ILE831C, ILE831D, ILE832C, ILE832D, LEU593C, LEU593D, LEU620C, LEU620D, LEU637C, LEU637D, LEU641C, LEU641D, LEU646C, LEU646D, LEU647C, LEU647D, LEU650C, LEU650D, LEU663C, LEU663D, LEU784C, LEU784D, PHE599C, PHE599D, PHE771C, PHE771D, PHE785C, PHE785D, SER592C, SER592D, SER597C, SER597D, SER638C, SER638D, SER642C, SER642D, SER649C, SER649D, SER782C, SER782D, SER828C, SER828D, THR639C, THR639D, THR783C, THR783D, TRP662C, TRP662D, TYR595C, TYR595D, TYR625C, TYR625D, TYR658C, TYR658D, TYR659C, TYR659D, TYR825C, TYR825D, VAL644C, VAL644D, VAL772C, VAL772D
• E-F: ALA596E, ALA596F, ALA619E, ALA619F, ALA648E, ALA648F, ALA660E, ALA660F, ALA661E, ALA661F, ARG594E, ARG594F, ARG623E, ARG623F, ARG657E, ARG657F, ARG768E, ARG768F, ARG769E, ARG769F, ARG834F, ASN618E, ASN618F, ASN651E, ASN651F, ASN770E, ASN770F, ASP598E, ASP598F, ASP621E, ASP621F, GLN787E, GLN787F, GLN829E, GLN829F, GLU634E, GLU634F, GLU635E, GLU635F, GLU643E, GLU643F, GLU664E, GLU664F, GLY830E, GLY830F, HIS652E, HIS652F, HIS827F, ILE640E, ILE640F, ILE826E, ILE826F, ILE831E, ILE831F, ILE832E, ILE832F, LEU593E, LEU593F, LEU620E, LEU620F, LEU637E, LEU637F, LEU641E, LEU641F, LEU646E, LEU646F, LEU647E, LEU647F, LEU650E, LEU650F, LEU663E, LEU663F, LEU784E, LEU784F, PHE599E, PHE599F, PHE785E, PHE785F, SER592E, SER592F, SER597E, SER597F, SER622E, SER638E, SER638F, SER642E, SER642F, SER649E, SER649F, SER782E, SER782F, SER828E, SER828F, THR639E, THR639F, THR783E, THR783F, TRP662E, TRP662F, TYR595E, TYR595F, TYR625E, TYR625F, TYR658E, TYR658F, TYR659E, TYR659F, TYR825E, TYR825F, VAL644E, VAL644F