1ZNJ

insulin, monoclinic crystal form

• Total interactions analyzed: 66
• Total true interactions: 39
• Strongest Interaction:
  • Chains: J-L
  • Int. Res.: 56
  • Norm. En. per Res.: -4.1879
• Hub Node: B(7)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-22.7932	-23.4011	694.238	648.0438	50	14	9	6049	1	3	2
A-D	0.0	0.0	-1.6004	-1.6004	11	0	0	150	0	0	0
A-F	0.0	0.0	-33.2056	-33.2056	17	1	1	1243	0	0	0
A-G	0.0	0.0	-3.3129	-3.3129	8	0	1	205	0	0	1
A-H	0.0	0.0	-8.6542	-8.6542	13	0	1	439	0	0	0
B-C	0.0	0.0	-3.6014	-3.6014	11	2	0	248	0	0	0
B-D	-56.0313	7.9038	-187.653	-235.7805	57	8	6	6596	0	8	6
B-F	0.0	11.4703	-24.1123	-12.642	22	1	1	1050	0	3	3
B-G	0.0	0.0	-9.7272	-9.7272	15	1	1	554	0	0	0
B-H	0.0	-1.2493	-6.6392	-7.8885	16	0	3	623	0	2	2
B-I	0.0	0.0	-44.0636	-44.0636	17	0	1	1459	0	0	0
B-J	0.0	11.165	-25.3399	-14.1749	21	1	1	1101	0	3	3
C-D	-18.8831	-30.295	1348.27	1299.0919	49	21	7	6160	2	3	2
C-I	0.0	0.0	-1.6115	-1.6115	6	0	0	173	0	0	0
C-J	0.0	0.0	-7.6561	-7.6561	12	0	1	448	0	0	0
C-L	0.0	0.0	-14.0446	-14.0446	16	4	1	1093	0	0	0
D-G	0.0	0.0	-37.0304	-37.0304	17	2	1	1297	0	0	0
D-H	0.0	10.9081	-23.1588	-12.2507	21	1	1	1039	0	3	3
D-I	0.0	0.0	-5.1371	-5.1371	12	0	0	352	0	0	0
D-J	0.0	10.7747	-11.6037	-0.829	16	0	3	748	0	2	2
D-L	0.0	12.0681	-24.2763	-12.2082	22	1	1	1048	0	3	3
E-F	-17.3183	-16.9313	1351.48	1317.2304	48	20	9	5777	1	3	2
E-H	0.0	0.0	-8.5052	-8.5052	12	0	0	299	0	0	1
E-J	-4.5912	0.0	-39.9883	-44.5795	16	1	1	1311	0	0	0
E-K	0.0	0.0	-1.8649	-1.8649	6	0	1	192	0	0	1
E-L	0.0	0.0	-8.6627	-8.6627	13	0	0	607	0	0	0
F-G	0.0	0.0	-5.2469	-5.2469	9	1	0	232	0	0	1
F-H	-75.2652	12.9235	442.589	380.2472	53	63	7	7125	0	7	5
F-J	0.0	11.75	-42.2566	-30.5066	23	3	1	1600	0	3	3
F-K	0.0	0.0	-9.1985	-9.1985	16	0	2	517	0	0	0
F-L	0.0	2.7388	-17.323	-14.5842	19	0	3	1009	0	2	2
G-H	-22.7634	-18.6565	586.913	545.4931	48	17	7	5639	1	2	2
H-K	0.0	0.0	-41.6224	-41.6224	17	0	1	1421	0	0	0
H-L	0.0	11.4442	-24.9793	-13.5351	21	2	1	1060	0	3	4
I-J	-19.4526	-16.0835	644.137	608.6009	49	17	8	6356	1	3	2
I-L	0.0	0.0	-8.8997	-8.8997	11	3	0	326	0	0	1
J-K	0.0	0.0	-1.4902	-1.4902	8	0	0	134	0	0	1
J-L	-44.4901	7.8673	-197.9	-234.5228	56	6	6	6594	0	8	6
K-L	-19.4361	-31.0546	636.39	585.8992	50	19	7	5983	2	3	2

Interface residues

• A-B: ALA14B, ARG22B, ASN18A, ASN21A, ASN3B, CYS11A, CYS19B, CYS20A, CYS6A, CYS7A, CYS7B, GLN15A, GLN4B, GLN5A, GLU13B, GLU17A, GLU21B, GLU4A, GLY1A, GLY20B, GLY23B, GLY8B, HIS10B, HIS5B, ILE10A, ILE2A, LEU11B, LEU13A, LEU15B, LEU16A, LEU17B, LEU6B, LYS29B, PHE1B, PHE24B, PHE25B, PRO28B, SER12A, SER9A, SER9B, THR27B, THR30B, THR8A, TYR14A, TYR16B, TYR19A, TYR26B, VAL12B, VAL18B, VAL3A
• A-D: ASN21A, CYS20A, CYS7A, ILE2A, LYS29D, PHE25D, PRO28D, THR27D, TYR16D, TYR26D, VAL3A
• A-F: ASN3F, CYS11A, CYS6A, CYS7A, GLN4F, GLN5A, HIS5F, ILE10A, LEU13A, LEU16A, LEU6F, PHE1F, SER12A, SER9A, THR8A, VAL2F, VAL3A
• A-G: GLU17A, GLU17G, LEU13A, LEU13G, LEU16A, LEU16G, TYR14A, TYR14G
• A-H: ALA14H, CYS11A, CYS19H, GLU21H, GLY20H, ILE10A, LEU13A, LEU15H, LEU16A, LEU17H, SER12A, TYR16H, VAL18H
• B-C: ASN21C, CYS20C, CYS7C, ILE2C, PHE24B, PHE25B, PRO28B, THR27B, TYR16B, TYR26B, VAL3C
• B-D: ALA14B, ALA14D, ARG22B, ARG22D, ASN3B, ASN3D, CYS19B, CYS19D, CYS7B, CYS7D, GLN4B, GLN4D, GLU13B, GLU13D, GLU21B, GLU21D, GLY20B, GLY20D, GLY23B, GLY23D, GLY8B, GLY8D, HIS10B, HIS10D, HIS5B, HIS5D, LEU11B, LEU11D, LEU15B, LEU15D, LEU17B, LEU17D, LEU6B, LEU6D, LYS29B, LYS29D, PHE24B, PHE24D, PHE25B, PHE25D, PRO28B, PRO28D, SER9B, SER9D, THR27B, THR27D, THR30B, TYR16B, TYR16D, TYR26B, TYR26D, VAL12B, VAL12D, VAL18B, VAL18D, VAL2B, VAL2D
• B-F: ALA14B, ASN3B, ASN3F, CYS7B, CYS7F, GLN4B, GLU13B, GLU13F, GLY8B, GLY8F, HIS10B, HIS10F, HIS5B, HIS5F, LEU11B, LEU6B, LEU6F, PHE1F, SER9B, SER9F, VAL2B, VAL2F
• B-G: ALA14B, ARG22B, CYS11G, CYS19B, GLU21B, GLY20B, ILE10G, LEU13G, LEU15B, LEU16G, LEU17B, SER12G, TYR14G, TYR16B, VAL18B
• B-H: ALA14B, ALA14H, GLU13B, GLU13H, HIS10B, HIS10H, LEU11B, LEU11H, LEU15B, LEU15H, LEU17B, LEU17H, TYR16B, TYR16H, VAL18B, VAL18H
• B-I: ASN3B, CYS11I, CYS6I, CYS7I, GLN4B, GLN5I, HIS5B, ILE10I, LEU13I, LEU16I, LEU6B, PHE1B, SER12I, SER9I, THR8I, VAL2B, VAL3I
• B-J: ALA14J, ASN3B, ASN3J, CYS7B, CYS7J, GLN4J, GLU13B, GLU13J, GLY8B, GLY8J, HIS10B, HIS10J, HIS5B, HIS5J, LEU11J, LEU6B, LEU6J, PHE1J, SER9B, SER9J, VAL2B
• C-D: ALA14D, ARG22D, ASN18C, ASN21C, ASN3D, CYS11C, CYS19D, CYS20C, CYS6C, CYS7C, CYS7D, GLN15C, GLN4D, GLN5C, GLU13D, GLU17C, GLU21D, GLU4C, GLY1C, GLY20D, GLY23D, GLY8D, HIS10D, HIS5D, ILE10C, ILE2C, LEU11D, LEU13C, LEU15D, LEU16C, LEU17D, LEU6D, LYS29D, PHE1D, PHE24D, PHE25D, PRO28D, SER12C, SER9C, SER9D, THR27D, THR8C, TYR14C, TYR16D, TYR19C, TYR26D, VAL12D, VAL18D, VAL3C
• C-I: GLU17C, GLU17I, LEU13C, LEU13I, LEU16I, TYR14C
• C-J: ALA14J, CYS11C, CYS19J, GLY20J, ILE10C, LEU13C, LEU15J, LEU16C, LEU17J, SER12C, TYR16J, VAL18J
• C-L: ASN3L, CYS11C, CYS6C, CYS7C, GLN4L, HIS5L, ILE10C, LEU13C, LEU16C, LEU6L, PHE1L, SER12C, SER9C, THR8C, VAL2L, VAL3C
• D-G: ASN3D, CYS11G, CYS6G, CYS7G, GLN4D, GLN5G, HIS5D, ILE10G, LEU13G, LEU16G, LEU6D, PHE1D, SER12G, SER9G, THR8G, VAL2D, VAL3G
• D-H: ALA14H, ASN3D, ASN3H, CYS7D, CYS7H, GLN4H, GLU13D, GLU13H, GLY8D, GLY8H, HIS10D, HIS10H, HIS5D, HIS5H, LEU11H, LEU6D, LEU6H, SER9D, SER9H, VAL2D, VAL2H
• D-I: ALA14D, CYS19D, GLU21D, GLY20D, ILE10I, LEU13I, LEU15D, LEU16I, LEU17D, SER12I, TYR16D, VAL18D
• D-J: ALA14D, ALA14J, GLU13D, GLU13J, HIS10D, HIS10J, LEU11D, LEU15D, LEU15J, LEU17D, LEU17J, TYR16D, TYR16J, VAL12D, VAL18D, VAL18J
• D-L: ALA14D, ASN3D, ASN3L, CYS7D, CYS7L, GLN4D, GLU13D, GLU13L, GLY8D, GLY8L, HIS10D, HIS10L, HIS5D, HIS5L, LEU11D, LEU11L, LEU6D, LEU6L, SER9D, SER9L, VAL2D, VAL2L
• E-F: ALA14F, ARG22F, ASN18E, ASN21E, ASN3F, CYS11E, CYS19F, CYS20E, CYS6E, CYS7E, CYS7F, GLN15E, GLN4F, GLN5E, GLU13F, GLU17E, GLU21F, GLU4E, GLY1E, GLY20F, GLY23F, GLY8F, HIS10F, HIS5F, ILE10E, ILE2E, LEU11F, LEU13E, LEU15F, LEU16E, LEU17F, LEU6F, LYS29F, PHE24F, PHE25F, PRO28F, SER12E, SER9E, SER9F, THR27F, THR8E, TYR14E, TYR16F, TYR19E, TYR26F, VAL12F, VAL18F, VAL3E
• E-H: ASN21E, CYS20E, CYS7E, ILE2E, PHE24H, PHE25H, PRO28H, THR27H, TYR16H, TYR19E, TYR26H, VAL3E
• E-J: ASN3J, CYS11E, CYS6E, CYS7E, GLN4J, GLN5E, HIS5J, ILE10E, LEU13E, LEU16E, LEU6J, PHE1J, SER9E, THR8E, VAL2J, VAL3E
• E-K: GLU17E, GLU17K, LEU13E, LEU13K, LEU16E, TYR14K
• E-L: ALA14L, ARG22L, CYS11E, CYS19L, GLU21L, GLY20L, ILE10E, LEU13E, LEU16E, LEU17L, SER12E, TYR16L, VAL18L
• F-G: ASN21G, CYS20G, ILE2G, PHE25F, PRO28F, THR27F, TYR16F, TYR26F, VAL3G
• F-H: ALA14F, ALA14H, ARG22F, ARG22H, ASN3H, CYS19F, CYS19H, CYS7F, CYS7H, GLN4F, GLN4H, GLU13F, GLU13H, GLU21F, GLU21H, GLY20F, GLY20H, GLY23F, GLY23H, GLY8F, GLY8H, HIS10F, HIS10H, HIS5F, HIS5H, LEU11F, LEU11H, LEU15F, LEU15H, LEU17F, LEU17H, LEU6F, LEU6H, LYS29F, PHE24F, PHE24H, PHE25F, PHE25H, PRO28F, PRO28H, SER9F, SER9H, THR27F, THR27H, TYR16F, TYR16H, TYR26F, TYR26H, VAL12F, VAL12H, VAL18F, VAL18H, VAL2H
• F-J: ALA14F, ASN3F, ASN3J, CYS7F, CYS7J, GLN4F, GLU13F, GLU13J, GLY8F, GLY8J, HIS10F, HIS10J, HIS5F, HIS5J, LEU11F, LEU11J, LEU6F, LEU6J, PHE1J, SER9F, SER9J, VAL2F, VAL2J
• F-K: ALA14F, ARG22F, CYS11K, CYS19F, GLU13F, GLU21F, GLY20F, ILE10K, LEU13K, LEU15F, LEU16K, LEU17F, SER12K, TYR14K, TYR16F, VAL18F
• F-L: ALA14F, ALA14L, CYS19F, GLU13F, GLU13L, HIS10F, HIS10L, LEU11F, LEU11L, LEU15F, LEU15L, LEU17F, LEU17L, SER9L, TYR16F, TYR16L, VAL12L, VAL18F, VAL18L
• G-H: ALA14H, ARG22H, ASN18G, ASN21G, ASN3H, CYS11G, CYS19H, CYS20G, CYS6G, CYS7G, CYS7H, GLN15G, GLN4H, GLN5G, GLU13H, GLU17G, GLU21H, GLU4G, GLY1G, GLY20H, GLY23H, GLY8H, HIS10H, HIS5H, ILE10G, ILE2G, LEU11H, LEU13G, LEU15H, LEU16G, LEU17H, LEU6H, PHE1H, PHE24H, PHE25H, PRO28H, SER12G, SER9G, SER9H, THR27H, THR8G, TYR14G, TYR16H, TYR19G, TYR26H, VAL12H, VAL18H, VAL3G
• H-K: ASN3H, CYS11K, CYS6K, CYS7K, GLN4H, GLN5K, HIS5H, ILE10K, LEU13K, LEU16K, LEU6H, PHE1H, SER12K, SER9K, THR8K, VAL2H, VAL3K
• H-L: ALA14L, ASN3H, ASN3L, CYS7H, CYS7L, GLN4L, GLU13H, GLU13L, GLY8H, GLY8L, HIS10H, HIS10L, HIS5H, HIS5L, LEU11L, LEU6H, LEU6L, SER9H, SER9L, VAL2H, VAL2L
• I-J: ALA14J, ARG22J, ASN18I, ASN21I, ASN3J, CYS11I, CYS19J, CYS20I, CYS6I, CYS7I, CYS7J, GLN15I, GLN4J, GLN5I, GLU13J, GLU17I, GLU21J, GLU4I, GLY1I, GLY20J, GLY23J, GLY8J, HIS10J, HIS5J, ILE10I, ILE2I, LEU11J, LEU13I, LEU15J, LEU16I, LEU17J, LEU6J, LYS29J, PHE24J, PHE25J, PRO28J, SER12I, SER9I, SER9J, THR27J, THR30J, THR8I, TYR14I, TYR16J, TYR19I, TYR26J, VAL12J, VAL18J, VAL3I
• I-L: ASN21I, CYS20I, ILE2I, PHE24L, PHE25L, PRO28L, THR27L, TYR16L, TYR19I, TYR26L, VAL3I
• J-K: ASN21K, ILE2K, PHE25J, PRO28J, THR27J, TYR16J, TYR26J, VAL3K
• J-L: ALA14J, ALA14L, ARG22J, ARG22L, ASN3L, CYS19J, CYS19L, CYS7J, CYS7L, GLN4J, GLN4L, GLU13J, GLU13L, GLU21J, GLU21L, GLY20J, GLY20L, GLY23J, GLY23L, GLY8J, GLY8L, HIS10J, HIS10L, HIS5J, HIS5L, LEU11J, LEU11L, LEU15J, LEU15L, LEU17J, LEU17L, LEU6J, LEU6L, LYS29J, LYS29L, PHE1L, PHE24J, PHE24L, PHE25J, PHE25L, PRO28J, PRO28L, SER9J, SER9L, THR27J, THR27L, TYR16J, TYR16L, TYR26J, TYR26L, VAL12J, VAL12L, VAL18J, VAL18L, VAL2J, VAL2L
• K-L: ALA14L, ARG22L, ASN18K, ASN21K, ASN3L, CYS11K, CYS19L, CYS20K, CYS6K, CYS7K, CYS7L, GLN15K, GLN4L, GLN5K, GLU13L, GLU17K, GLU21L, GLU4K, GLY1K, GLY20L, GLY23L, GLY8L, HIS10L, HIS5L, ILE10K, ILE2K, LEU11L, LEU13K, LEU15L, LEU16K, LEU17L, LEU6L, LYS29L, PHE1L, PHE24L, PHE25L, PRO28L, SER12K, SER9K, SER9L, THR27L, THR30L, THR8K, TYR14K, TYR16L, TYR19K, TYR26L, VAL12L, VAL18L, VAL3K