1ZMD

crystal structure of human dihydrolipoamide dehydrogenase complexed to nadh

• Total interactions analyzed: 28
• Total true interactions: 11
• Strongest Interaction:
  • Chains: G-H
  • Int. Res.: 340
  • Norm. En. per Res.: -4.2188
• Hub Node: A(5)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-254.6276	-78.5933	-1021.78	-1355.0009	337	55	32	42941	23	107	117
A-E	-5.447	-21.5912	-55.8323	-82.8705	55	0	0	2645	1	18	11
A-F	-39.8915	-71.6442	-135.66	-247.1957	84	6	1	4768	4	27	28
A-G	0.0	0.0	-0.1452	-0.1452	10	0	0	45	0	9	6
A-H	-7.205	0.0	-11.802	-19.007	12	1	0	377	0	3	3
B-D	0.0	14.2114	-4.6901	9.5213	25	0	0	516	1	11	10
B-F	-3.5828	-19.3354	-60.1787	-83.0969	55	0	0	2705	1	18	11
C-D	-255.3767	-127.8802	-1049.53	-1432.7869	343	55	32	43644	23	110	117
E-F	-237.4217	-77.6356	-1081.95	-1397.0073	341	41	33	43338	23	108	117
F-G	0.0	-14.6006	-104.802	-119.4026	90	0	1	5673	0	46	51
G-H	-291.1555	-73.0721	-1070.16	-1434.3876	340	46	32	43380	22	107	118

Interface residues

• A-B: ALA21A, ALA21B, ALA22A, ALA22B, ALA25A, ALA25B, ALA26A, ALA26B, ALA328A, ALA328B, ALA331A, ALA331B, ALA346A, ALA346B, ALA365A, ALA365B, ALA389A, ALA389B, ALA390A, ALA390B, ALA394A, ALA394B, ALA398A, ALA398B, ALA425A, ALA425B, ALA432A, ALA432B, ALA433A, ALA433B, ALA435A, ALA435B, ALA440A, ALA440B, ALA446A, ALA446B, ALA451A, ALA451B, ALA458A, ALA458B, ALA55A, ALA55B, ALA66A, ALA66B, ALA72A, ALA72B, ALA95A, ALA95B, ALA98A, ALA98B, ARG393A, ARG393B, ARG447A, ARG447B, ARG460A, ARG460B, ARG74A, ARG74B, ARG82A, ARG82B, ASN110A, ASN110B, ASN391A, ASN391B, ASN397A, ASN397B, ASN430A, ASN430B, ASN463A, ASN463B, ASN473A, ASN473B, ASN58A, ASN58B, ASN59A, ASN59B, ASN84A, ASN84B, ASP333A, ASP333B, ASP350A, ASP350B, ASP399A, ASP399B, ASP444A, ASP444B, ASP70A, ASP70B, ASP86A, ASP86B, CYS353A, CYS353B, CYS442A, CYS449A, CYS449B, CYS45A, CYS45B, CYS50A, CYS50B, GLN109A, GLN109B, GLN27A, GLN27B, GLN91A, GLN91B, GLU192A, GLU192B, GLU332A, GLU332B, GLU334A, GLU334B, GLU340A, GLU340B, GLU363A, GLU363B, GLU427A, GLU427B, GLU431A, GLU431B, GLU437A, GLU437B, GLU443A, GLU443B, GLU457A, GLU457B, GLU461A, GLU461B, GLU77A, GLU77B, GLU80A, GLU80B, GLU90A, GLU90B, GLY102A, GLY102B, GLY29A, GLY29B, GLY345A, GLY345B, GLY424A, GLY424B, GLY426A, GLY426B, GLY439A, GLY439B, GLY469A, GLY469B, GLY49A, GLY49B, GLY75A, GLY75B, HIS105B, HIS329A, HIS329B, HIS348A, HIS348B, HIS361A, HIS361B, HIS450A, HIS450B, HIS452A, HIS452B, HIS61A, HIS61B, HIS64A, HIS64B, HIS67A, HIS67B, ILE103A, ILE103B, ILE23A, ILE23B, ILE336A, ILE336B, ILE337A, ILE337B, ILE349A, ILE349B, ILE358A, ILE358B, ILE445A, ILE445B, ILE472A, ILE472B, ILE51A, ILE51B, ILE76A, ILE76B, LEU106A, LEU106B, LEU200A, LEU200B, LEU28A, LEU28B, LEU327A, LEU327B, LEU434A, LEU434B, LEU436A, LEU436B, LEU455A, LEU455B, LEU464A, LEU464B, LEU46A, LEU46B, LEU56A, LEU56B, LEU57A, LEU57B, LEU83A, LEU83B, LEU85A, LEU85B, LEU99A, LEU99B, LYS111A, LYS24A, LYS24B, LYS330A, LYS330B, LYS395A, LYS395B, LYS470A, LYS470B, LYS54A, LYS54B, LYS87A, LYS87B, LYS92A, LYS92B, LYS97A, LYS97B, MET428A, MET428B, MET65A, MET65B, MET78A, MET78B, MET88A, MET88B, MET89A, MET89B, PHE107A, PHE107B, PHE386A, PHE386B, PHE388A, PHE388B, PHE459A, PHE459B, PHE468A, PHE468B, PHE474A, PHE474B, PHE71A, PHE71B, PRO16A, PRO16B, PRO325A, PRO325B, PRO355A, PRO355B, PRO423A, PRO423B, PRO453A, PRO453B, PRO52A, PRO52B, SER356A, SER356B, SER392A, SER392B, SER441A, SER441B, SER456A, SER456B, SER467A, SER471A, SER471B, SER53A, SER53B, SER60A, SER60B, SER73A, SER73B, SER79A, SER79B, THR100A, THR360A, THR360B, THR396A, THR396B, THR400A, THR400B, THR454A, THR454B, THR69A, THR69B, THR94A, THR94B, TRP366A, TRP366B, TYR19A, TYR19B, TYR351A, TYR351B, TYR359A, TYR359B, TYR438A, TYR438B, TYR62A, TYR62B, TYR63A, TYR63B, VAL20A, VAL20B, VAL339A, VAL339B, VAL347A, VAL347B, VAL354A, VAL354B, VAL357A, VAL357B, VAL367A, VAL367B, VAL415A, VAL415B, VAL429A, VAL429B, VAL448A, VAL448B, VAL81A, VAL81B, VAL96A, VAL96B
• A-E: ALA343A, ALA346A, ALA346E, ALA435E, ALA440E, ARG307A, ARG414E, ARG447E, ASN143A, ASN305A, ASN314A, ASP413E, ASP444E, ASP8A, CYS442E, GLN309A, GLN409E, GLU291A, GLU340A, GLU437E, GLU443E, GLY293A, GLY29A, GLY341A, GLY344A, GLY345A, GLY439E, HIS348A, HIS348E, ILE312A, ILE349E, ILE379E, ILE445E, LEU28A, LEU292A, LEU436E, LYS124A, LYS142A, LYS311A, LYS382E, MET342A, PHE30A, PRO313A, SER411E, SER441E, SER467E, THR306A, THR310A, THR412E, TYR316A, TYR438E, VAL347A, VAL347E, VAL415E, VAL448E
• A-F: ALA323F, ALA346A, ALA346F, ALA435A, ALA435F, ALA440A, ALA440F, ARG301A, ARG301F, ARG307A, ARG307F, ARG414A, ARG414F, ARG447A, ARG447F, ASN305A, ASN305F, ASP297A, ASP297F, ASP350A, ASP350F, ASP413A, ASP444A, ASP444F, CYS353A, CYS353F, GLN309A, GLN309F, GLU295A, GLU295F, GLU377A, GLU377F, GLU437A, GLU437F, GLU443A, GLU443F, GLY341A, GLY341F, GLY344A, GLY344F, GLY345A, GLY345F, GLY439A, GLY439F, HIS348A, HIS348F, ILE312F, ILE349A, ILE349F, LEU434A, LEU434F, LEU436A, LEU436F, LYS311A, LYS311F, MET342A, MET342F, PHE308A, PHE308F, PRO298A, PRO298F, PRO303A, PRO303F, PRO313A, PRO313F, SER411A, SER411F, SER441A, SER441F, THR306A, THR306F, THR310A, THR310F, THR412A, THR412F, TYR316A, TYR316F, TYR438A, TYR438F, VAL304A, VAL304F, VAL347A, VAL347F, VAL448A
• A-G: ARG228G, GLN231G, GLU267G, GLU376A, GLU380A, GLY378A, LYS236G, LYS238G, LYS265G, SER411A
• A-H: ALA260A, ALA261A, ALA98H, GLU259A, GLU39H, GLY101H, GLY263A, GLY264A, LYS242A, LYS265A, LYS97H, SER262A
• B-D: ALA132D, ASN305B, ASP133D, ASP140B, ASP161D, ASP163D, ASP251D, ASP6B, GLN126B, GLN309B, GLU39D, GLY134D, GLY252D, ILE312B, LEU292B, LYS124B, LYS248D, LYS249D, LYS311B, PRO313B, PRO4B, SER250D, THR164D, THR310B, VAL138B
• B-F: ALA343F, ALA346B, ALA346F, ALA440B, ARG307F, ARG414B, ARG447B, ASN143F, ASN305F, ASN314F, ASP350B, ASP413B, ASP444B, ASP8F, CYS442B, GLN309F, GLN409B, GLU291F, GLU340F, GLU437B, GLU443B, GLY293F, GLY29F, GLY341F, GLY344F, GLY345B, GLY345F, GLY439B, HIS348B, HIS348F, ILE312F, ILE349B, ILE445B, LEU28F, LEU292F, LEU436B, LYS124F, LYS142F, LYS311F, LYS382B, MET342F, PHE30F, PRO313F, SER411B, SER441B, SER467B, THR306F, THR310F, THR412B, TYR316F, TYR438B, VAL347B, VAL347F, VAL415B, VAL448B
• C-D: ALA21C, ALA21D, ALA22C, ALA22D, ALA25C, ALA25D, ALA26C, ALA26D, ALA328C, ALA328D, ALA331C, ALA331D, ALA346C, ALA346D, ALA365C, ALA365D, ALA389C, ALA389D, ALA390C, ALA390D, ALA394C, ALA394D, ALA398C, ALA398D, ALA425C, ALA425D, ALA432C, ALA432D, ALA433C, ALA433D, ALA435C, ALA435D, ALA440C, ALA440D, ALA446C, ALA446D, ALA451C, ALA451D, ALA458C, ALA458D, ALA465C, ALA465D, ALA55C, ALA55D, ALA66C, ALA66D, ALA72C, ALA72D, ALA95C, ALA95D, ALA98C, ALA98D, ARG393C, ARG393D, ARG447C, ARG447D, ARG460C, ARG460D, ARG74C, ARG74D, ARG82C, ARG82D, ASN110C, ASN110D, ASN391C, ASN391D, ASN397C, ASN397D, ASN430C, ASN430D, ASN463C, ASN463D, ASN473C, ASN473D, ASN58C, ASN58D, ASN59C, ASN59D, ASN84C, ASN84D, ASP333C, ASP333D, ASP350C, ASP350D, ASP399C, ASP399D, ASP444C, ASP444D, ASP70C, ASP70D, ASP86C, ASP86D, CYS353C, CYS353D, CYS442D, CYS449C, CYS449D, CYS45C, CYS45D, CYS50C, CYS50D, GLN109C, GLN109D, GLN27C, GLN27D, GLN91C, GLN91D, GLU192C, GLU192D, GLU332C, GLU332D, GLU334C, GLU334D, GLU340C, GLU340D, GLU363C, GLU363D, GLU427C, GLU427D, GLU431C, GLU431D, GLU437C, GLU437D, GLU443C, GLU443D, GLU457C, GLU457D, GLU461C, GLU461D, GLU77C, GLU77D, GLU80C, GLU80D, GLU90C, GLU90D, GLY102C, GLY102D, GLY29C, GLY29D, GLY335C, GLY345C, GLY345D, GLY424C, GLY424D, GLY426C, GLY426D, GLY439C, GLY439D, GLY469C, GLY469D, GLY49C, GLY49D, GLY75C, GLY75D, HIS105C, HIS105D, HIS329C, HIS329D, HIS348C, HIS348D, HIS361C, HIS361D, HIS450C, HIS450D, HIS452C, HIS452D, HIS61C, HIS61D, HIS64C, HIS64D, HIS67C, HIS67D, ILE103C, ILE103D, ILE23C, ILE23D, ILE336C, ILE336D, ILE337C, ILE337D, ILE349C, ILE349D, ILE358C, ILE358D, ILE445C, ILE445D, ILE472C, ILE472D, ILE51C, ILE51D, ILE76C, ILE76D, LEU106C, LEU106D, LEU200C, LEU200D, LEU28C, LEU28D, LEU327C, LEU327D, LEU434C, LEU434D, LEU436C, LEU436D, LEU455C, LEU455D, LEU464C, LEU464D, LEU46C, LEU46D, LEU56C, LEU56D, LEU57C, LEU57D, LEU83C, LEU83D, LEU85C, LEU85D, LEU99C, LEU99D, LYS111C, LYS111D, LYS24C, LYS24D, LYS330C, LYS330D, LYS395C, LYS395D, LYS470C, LYS470D, LYS54C, LYS54D, LYS87C, LYS87D, LYS92C, LYS92D, LYS97C, LYS97D, MET428C, MET428D, MET65C, MET65D, MET78C, MET78D, MET88C, MET88D, MET89C, MET89D, PHE107C, PHE107D, PHE386C, PHE386D, PHE388C, PHE388D, PHE459C, PHE459D, PHE468C, PHE468D, PHE474C, PHE474D, PHE71C, PHE71D, PRO16C, PRO16D, PRO325C, PRO325D, PRO355C, PRO355D, PRO423C, PRO423D, PRO453C, PRO453D, PRO52C, PRO52D, SER356C, SER356D, SER392C, SER392D, SER441C, SER441D, SER456C, SER456D, SER467C, SER467D, SER471C, SER471D, SER53C, SER53D, SER60C, SER60D, SER73C, SER73D, SER79C, SER79D, THR100D, THR360C, THR360D, THR396C, THR396D, THR400C, THR400D, THR454C, THR454D, THR69C, THR69D, THR94C, THR94D, TRP366C, TRP366D, TYR19C, TYR19D, TYR351C, TYR351D, TYR359C, TYR359D, TYR438C, TYR438D, TYR62C, TYR62D, TYR63C, TYR63D, VAL20C, VAL20D, VAL339C, VAL339D, VAL347C, VAL347D, VAL354C, VAL354D, VAL357C, VAL357D, VAL367C, VAL367D, VAL415C, VAL415D, VAL429C, VAL429D, VAL448C, VAL448D, VAL81C, VAL81D, VAL96C, VAL96D
• E-F: ALA21E, ALA21F, ALA22E, ALA22F, ALA25E, ALA25F, ALA26E, ALA26F, ALA328E, ALA328F, ALA331E, ALA331F, ALA346E, ALA346F, ALA365E, ALA365F, ALA389E, ALA389F, ALA390E, ALA390F, ALA394E, ALA394F, ALA398E, ALA398F, ALA425E, ALA425F, ALA432E, ALA432F, ALA433E, ALA433F, ALA435E, ALA435F, ALA440E, ALA440F, ALA446E, ALA446F, ALA451E, ALA451F, ALA458E, ALA458F, ALA465E, ALA55E, ALA55F, ALA66E, ALA66F, ALA72E, ALA72F, ALA95E, ALA95F, ALA98E, ALA98F, ARG393E, ARG393F, ARG414E, ARG414F, ARG447E, ARG447F, ARG460E, ARG460F, ARG74E, ARG74F, ARG82E, ARG82F, ASN110E, ASN110F, ASN391E, ASN391F, ASN397E, ASN397F, ASN430E, ASN430F, ASN463E, ASN463F, ASN473E, ASN473F, ASN58E, ASN58F, ASN59E, ASN59F, ASN84E, ASN84F, ASP333E, ASP333F, ASP350E, ASP350F, ASP399E, ASP399F, ASP444E, ASP444F, ASP70E, ASP70F, ASP86E, ASP86F, CYS353E, CYS353F, CYS449E, CYS449F, CYS45E, CYS45F, CYS50E, CYS50F, GLN109E, GLN109F, GLN27E, GLN27F, GLN91E, GLN91F, GLU192E, GLU192F, GLU332E, GLU332F, GLU334E, GLU334F, GLU340E, GLU340F, GLU363E, GLU363F, GLU427E, GLU427F, GLU431E, GLU431F, GLU437E, GLU437F, GLU443E, GLU443F, GLU457E, GLU457F, GLU461E, GLU461F, GLU77E, GLU77F, GLU80E, GLU80F, GLU90E, GLU90F, GLY102E, GLY102F, GLY29E, GLY29F, GLY345E, GLY345F, GLY424E, GLY424F, GLY426E, GLY426F, GLY439E, GLY439F, GLY469E, GLY469F, GLY49E, GLY49F, GLY75E, GLY75F, HIS105E, HIS105F, HIS329E, HIS329F, HIS348E, HIS348F, HIS361E, HIS361F, HIS450E, HIS450F, HIS452E, HIS452F, HIS61E, HIS61F, HIS64E, HIS64F, HIS67E, HIS67F, ILE103E, ILE103F, ILE23E, ILE23F, ILE336E, ILE336F, ILE337E, ILE337F, ILE349E, ILE349F, ILE358E, ILE358F, ILE445E, ILE445F, ILE472E, ILE472F, ILE51E, ILE51F, ILE76E, ILE76F, LEU106E, LEU106F, LEU200E, LEU200F, LEU28E, LEU28F, LEU327E, LEU327F, LEU434E, LEU434F, LEU436E, LEU436F, LEU455E, LEU455F, LEU464E, LEU464F, LEU46E, LEU46F, LEU56E, LEU56F, LEU57E, LEU57F, LEU83E, LEU83F, LEU85E, LEU85F, LEU99E, LEU99F, LYS111E, LYS111F, LYS24E, LYS24F, LYS330E, LYS330F, LYS395E, LYS395F, LYS470E, LYS470F, LYS54E, LYS54F, LYS87E, LYS87F, LYS92E, LYS92F, LYS97E, LYS97F, MET428E, MET428F, MET65E, MET65F, MET78E, MET78F, MET88E, MET88F, MET89E, MET89F, PHE107E, PHE107F, PHE386E, PHE386F, PHE388E, PHE388F, PHE459E, PHE459F, PHE468E, PHE468F, PHE474E, PHE474F, PHE71E, PHE71F, PRO16E, PRO16F, PRO355E, PRO355F, PRO423E, PRO423F, PRO453E, PRO453F, PRO52E, PRO52F, SER356E, SER356F, SER392E, SER392F, SER441E, SER441F, SER456E, SER456F, SER467E, SER467F, SER471E, SER471F, SER53E, SER53F, SER60E, SER60F, SER73E, SER73F, SER79E, SER79F, THR100E, THR100F, THR360E, THR360F, THR396E, THR396F, THR400E, THR400F, THR454E, THR454F, THR69E, THR69F, THR94E, THR94F, TRP366E, TRP366F, TYR19E, TYR19F, TYR351E, TYR351F, TYR359E, TYR359F, TYR438E, TYR438F, TYR62E, TYR62F, TYR63E, TYR63F, VAL20E, VAL20F, VAL339E, VAL339F, VAL347E, VAL347F, VAL354E, VAL354F, VAL357E, VAL357F, VAL367E, VAL367F, VAL415E, VAL415F, VAL429E, VAL429F, VAL448E, VAL448F, VAL81E, VAL81F, VAL96E, VAL96F
• F-G: ALA260F, ALA260G, ALA261F, ALA261G, ALA266F, ALA266G, ARG228F, ARG228G, ARG280F, ARG280G, ARG281F, ARG281G, ARG299F, ARG299G, ARG301F, ARG301G, ASN240F, ASN240G, ASP297F, ASP297G, GLU208F, GLU208G, GLU221F, GLU221G, GLU259F, GLU259G, GLU267F, GLU267G, GLU371F, GLU371G, GLU372F, GLU372G, GLU376F, GLU376G, GLY211F, GLY211G, GLY215F, GLY263F, GLY263G, GLY264F, GLY264G, GLY279F, GLY279G, GLY300F, GLY300G, GLY378F, GLY378G, HIS212F, ILE278F, ILE278G, LEU210F, LEU210G, LYS224F, LYS224G, LYS242F, LYS242G, LYS265F, LYS265G, LYS375F, LYS375G, LYS385F, LYS385G, LYS405F, LYS405G, MET220F, MET220G, PHE155F, PHE155G, PHE209F, PHE209G, PRO154F, PRO154G, PRO156F, PRO156G, PRO282F, PRO282G, PRO298F, PRO298G, SER262F, SER262G, THR153F, THR153G, THR241F, THR241G, THR244F, THR244G, TYR381F, TYR381G, VAL216F, VAL243G
• G-H: ALA21G, ALA21H, ALA22G, ALA22H, ALA25G, ALA25H, ALA26G, ALA26H, ALA328G, ALA328H, ALA331G, ALA331H, ALA346G, ALA346H, ALA365G, ALA365H, ALA389G, ALA389H, ALA390G, ALA390H, ALA394G, ALA394H, ALA398G, ALA398H, ALA425G, ALA425H, ALA432G, ALA432H, ALA433G, ALA433H, ALA435G, ALA435H, ALA440G, ALA440H, ALA446G, ALA446H, ALA451G, ALA451H, ALA458G, ALA458H, ALA55G, ALA55H, ALA66G, ALA66H, ALA72G, ALA72H, ALA95G, ALA95H, ALA98G, ALA98H, ARG393G, ARG393H, ARG447G, ARG447H, ARG460G, ARG460H, ARG74G, ARG74H, ARG82G, ARG82H, ASN110G, ASN110H, ASN391G, ASN391H, ASN397G, ASN397H, ASN430G, ASN430H, ASN463G, ASN463H, ASN473G, ASN473H, ASN58G, ASN58H, ASN59G, ASN59H, ASN84G, ASN84H, ASP333G, ASP333H, ASP350G, ASP350H, ASP399G, ASP399H, ASP444G, ASP444H, ASP70G, ASP70H, ASP86G, ASP86H, CYS353G, CYS353H, CYS442G, CYS449G, CYS449H, CYS45G, CYS45H, CYS50G, CYS50H, GLN109G, GLN109H, GLN27G, GLN27H, GLN91G, GLN91H, GLU192G, GLU192H, GLU332G, GLU332H, GLU334G, GLU334H, GLU340G, GLU340H, GLU363G, GLU363H, GLU427G, GLU427H, GLU431G, GLU431H, GLU437G, GLU437H, GLU443G, GLU443H, GLU457G, GLU457H, GLU461G, GLU461H, GLU77G, GLU77H, GLU80G, GLU80H, GLU90G, GLU90H, GLY102G, GLY102H, GLY29G, GLY29H, GLY345G, GLY345H, GLY424G, GLY424H, GLY426G, GLY426H, GLY439G, GLY439H, GLY469G, GLY469H, GLY49G, GLY49H, GLY75G, GLY75H, HIS105G, HIS105H, HIS329G, HIS329H, HIS348G, HIS348H, HIS361G, HIS361H, HIS450G, HIS450H, HIS452G, HIS452H, HIS61G, HIS61H, HIS64G, HIS64H, HIS67G, HIS67H, ILE103G, ILE103H, ILE23G, ILE23H, ILE336G, ILE336H, ILE337G, ILE337H, ILE349G, ILE349H, ILE358G, ILE358H, ILE445G, ILE445H, ILE472G, ILE472H, ILE51G, ILE51H, ILE76G, ILE76H, LEU106G, LEU106H, LEU200G, LEU200H, LEU28G, LEU28H, LEU327G, LEU327H, LEU434G, LEU434H, LEU436G, LEU436H, LEU455G, LEU455H, LEU464G, LEU464H, LEU46G, LEU46H, LEU56G, LEU56H, LEU57G, LEU57H, LEU83G, LEU83H, LEU85G, LEU85H, LEU99G, LEU99H, LYS111G, LYS111H, LYS24G, LYS24H, LYS330G, LYS330H, LYS395G, LYS395H, LYS470G, LYS470H, LYS54G, LYS54H, LYS87G, LYS87H, LYS92G, LYS92H, LYS97G, LYS97H, MET428G, MET428H, MET65G, MET65H, MET78G, MET78H, MET88G, MET88H, MET89G, MET89H, PHE107G, PHE107H, PHE386G, PHE386H, PHE388G, PHE388H, PHE459G, PHE459H, PHE468G, PHE468H, PHE474G, PHE474H, PHE71G, PHE71H, PRO16G, PRO16H, PRO325G, PRO325H, PRO355G, PRO355H, PRO423G, PRO423H, PRO453G, PRO453H, PRO52G, PRO52H, SER356G, SER356H, SER392G, SER392H, SER441G, SER441H, SER456G, SER456H, SER467G, SER471G, SER471H, SER53G, SER53H, SER60G, SER60H, SER73G, SER73H, SER79G, SER79H, THR100G, THR100H, THR360G, THR360H, THR396G, THR396H, THR400G, THR400H, THR454G, THR454H, THR69G, THR69H, THR94G, THR94H, TRP366G, TRP366H, TYR19G, TYR19H, TYR351G, TYR351H, TYR359G, TYR359H, TYR438G, TYR438H, TYR62G, TYR62H, TYR63G, TYR63H, VAL20G, VAL20H, VAL339G, VAL339H, VAL347G, VAL347H, VAL354G, VAL354H, VAL357G, VAL357H, VAL367G, VAL367H, VAL415G, VAL415H, VAL429G, VAL429H, VAL448G, VAL448H, VAL81G, VAL81H, VAL96G, VAL96H