1ZH7

structural and biochemical basis for selective repression of the orphan nuclear receptor lrh-1 by shp

• Total interactions analyzed: 6
• Total true interactions: 3
• Strongest Interaction:
  • Chains: A-C
  • Int. Res.: 46
  • Norm. En. per Res.: -2.8506
• Hub Node: A(2)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-4.5095	-2.8469	-67.237	-74.5934	46	8	4	2875	0	15	15
A-C	-2.3874	-2.3318	-126.407	-131.1262	46	13	5	5767	0	3	4
B-D	-9.615	-2.3318	-123.064	-135.0107	48	5	5	5832	0	3	4

Interface residues

• A-B: ALA442A, ALA442B, ALA532B, ALA560A, ALA560B, ARG559A, ARG559B, ASN444A, ASN445A, ASN445B, ASN542A, ASN542B, ASP534A, ASP534B, ASP544A, ASP544B, GLN531A, GLN531B, GLU440A, GLU440B, GLU533B, GLY543B, HIS540B, LEU446A, LEU446B, LEU449A, LEU449B, LEU536B, LYS530A, LYS530B, LYS539A, LYS539B, LYS558B, PHE443A, PHE443B, THR439A, TYR535A, TYR535B, TYR537A, TYR537B, TYR538A, TYR538B, VAL441A, VAL441B, VAL541A, VAL541B
• A-C: ALA379A, ALA557A, ARG380A, ARG386A, ASN399A, ASN548A, ASN549A, ASP369A, ASP391A, ASP392A, GLN370A, GLN393A, GLN398A, GLU377A, GLU553A, HIS17C, HIS556A, ILE20C, ILE375A, LEU21C, LEU24C, LEU25C, LEU372A, LEU388A, LEU396A, LEU397A, LEU550A, LEU551A, LYS389A, LYS395A, LYS558A, MET394A, MET554A, PHE373A, PHE385A, PRO18C, SER16C, SER26C, SER374A, THR19C, THR23C, TRP401A, TYR22C, TYR547A, VAL376A, VAL390A
• B-D: ALA379B, ALA557B, ARG380B, ARG386B, ASN399B, ASN548B, ASN549B, ASP369B, ASP391B, ASP392B, GLN393B, GLN398B, GLU377B, GLU553B, HIS17D, HIS556B, ILE20D, ILE375B, ILE552B, LEU21D, LEU24D, LEU25D, LEU372B, LEU388B, LEU396B, LEU397B, LEU550B, LEU551B, LYS340B, LYS389B, LYS395B, LYS558B, MET394B, MET554B, PHE373B, PHE385B, PRO18D, SER16D, SER26D, SER374B, SER381B, THR19D, THR23D, TRP401B, TYR22D, TYR547B, VAL376B, VAL390B