1Z9H

microsomal prostaglandin e synthase type-2

• Total interactions analyzed: 6
• Total true interactions: 5
• Strongest Interaction:
  • Chains: B-D
  • Int. Res.: 22
  • Norm. En. per Res.: -3.3972
• Hub Node: A(2)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-2.5638	-43.3789	-299.056	-344.9987	121	35	0	13132	2	50	55
A-D	-10.0381	25.0243	-57.347	-42.3608	44	6	0	2490	0	22	18
B-C	0.0	22.9199	-56.3256	-33.4057	44	8	0	2523	0	22	18
B-D	0.0	-54.8218	-19.9177	-74.7395	22	0	0	1218	4	13	25
C-D	-5.2651	-42.5717	-298.973	-346.8097	121	33	0	13051	2	49	55

Interface residues

• A-B: ALA191A, ALA191B, ALA194A, ALA194B, ALA218A, ALA238A, ALA238B, ARG228A, ARG228B, ARG296A, ARG296B, ARG298A, ARG298B, ASN196A, ASN196B, ASN207A, ASN207B, ASN214A, ASN214B, ASP197A, ASP197B, ASP239A, ASP239B, ASP240A, ASP240B, GLN180A, GLN180B, GLN198A, GLN198B, GLN236A, GLN236B, GLU183A, GLU184A, GLU184B, GLU201A, GLU201B, GLU204A, GLU204B, GLU215A, GLU215B, GLU217A, GLU217B, GLU226A, GLU226B, GLU230A, GLU230B, GLY199A, GLY199B, GLY206A, GLY206B, GLY224B, HIS244A, HIS244B, HIS297A, HIS297B, ILE185A, ILE185B, ILE186A, ILE186B, LEU211A, LEU211B, LEU213A, LEU213B, LEU242A, LEU242B, LEU293A, LEU293B, LEU299A, LEU299B, LYS193A, LYS193B, LYS200A, LYS200B, LYS208A, LYS208B, LYS216A, LYS216B, LYS225A, LYS225B, LYS233A, LYS233B, LYS313A, LYS313B, MET192A, MET192B, MET212A, MET212B, MET232A, MET232B, PHE205A, PHE205B, PRO181A, PRO181B, PRO190A, PRO190B, SER178A, SER178B, SER295A, SER295B, THR187A, THR187B, THR203A, THR203B, THR229A, THR229B, TRP210A, TRP210B, TRP237A, TRP237B, TRP241A, TRP241B, TYR188A, TYR188B, TYR189A, TYR189B, TYR209A, TYR209B, VAL195A, VAL195B, VAL202A, VAL202B
• A-D: ALA138A, ALA257D, ALA259D, ALA283D, ALA284D, ARG137A, ARG146A, ARG252D, ASN133A, ASN302D, ASP301D, ASP348D, GLN198A, GLN300D, GLU139A, GLU201A, GLU256D, GLU274A, GLY199A, ILE140A, LEU136A, LEU258D, LEU288D, LEU299D, LYS141A, LYS193A, LYS200A, LYS279D, LYS291D, LYS294D, PRO134A, PRO254D, SER143A, SER144A, SER295D, THR203A, THR253D, THR255D, TYR280D, TYR287D, VAL135A, VAL195A, VAL202A, VAL273A
• B-C: ALA138C, ALA257B, ALA259B, ALA283B, ALA284B, ARG137C, ARG146C, ARG252B, ASN133C, ASN302B, ASP301B, ASP348B, GLN198C, GLN300B, GLU139C, GLU201C, GLU256B, GLU274C, GLY199C, ILE140C, LEU136C, LEU258B, LEU288B, LEU299B, LYS141C, LYS193C, LYS200C, LYS279B, LYS291B, LYS294B, PRO134C, PRO254B, SER143C, SER144C, SER295B, THR203C, THR253B, THR255B, TYR280B, TYR287B, VAL135C, VAL195C, VAL202C, VAL273C
• B-D: ARG296B, ARG296D, ARG298B, ARG298D, ASN302B, ASN302D, ASP301B, ASP301D, ASP306B, GLN300B, GLN300D, HIS297B, HIS297D, LEU299B, LEU299D, LYS291B, LYS291D, LYS294B, LYS294D, SER295B, SER295D, VAL303B
• C-D: ALA191C, ALA191D, ALA194C, ALA194D, ALA218C, ALA238C, ALA238D, ARG228C, ARG228D, ARG296C, ARG296D, ARG298C, ARG298D, ASN196C, ASN196D, ASN207C, ASN207D, ASN214C, ASN214D, ASP197C, ASP197D, ASP239C, ASP239D, ASP240C, ASP240D, GLN180C, GLN180D, GLN198C, GLN198D, GLN236C, GLN236D, GLU183C, GLU184C, GLU184D, GLU201C, GLU201D, GLU204C, GLU204D, GLU215C, GLU215D, GLU217C, GLU217D, GLU226C, GLU226D, GLU230C, GLU230D, GLY199C, GLY199D, GLY206C, GLY206D, GLY224D, HIS244C, HIS244D, HIS297C, HIS297D, ILE185C, ILE185D, ILE186C, ILE186D, LEU211C, LEU211D, LEU213C, LEU213D, LEU242C, LEU242D, LEU293C, LEU293D, LEU299C, LEU299D, LYS193C, LYS193D, LYS200C, LYS200D, LYS208C, LYS208D, LYS216C, LYS216D, LYS225C, LYS225D, LYS233C, LYS233D, LYS313C, LYS313D, MET192C, MET192D, MET212C, MET212D, MET232C, MET232D, PHE205C, PHE205D, PRO181C, PRO181D, PRO190C, PRO190D, SER178C, SER178D, SER295C, SER295D, THR187C, THR187D, THR203C, THR203D, THR229C, THR229D, TRP210C, TRP210D, TRP237C, TRP237D, TRP241C, TRP241D, TYR188C, TYR188D, TYR189C, TYR189D, TYR209C, TYR209D, VAL195C, VAL195D, VAL202C, VAL202D