1Z7N

atp phosphoribosyl transferase (hiszg atp-prtase) from lactococcus lactis with bound prpp substrate

• Total interactions analyzed: 28
• Total true interactions: 20
• Strongest Interaction:
  • Chains: B-G
  • Int. Res.: 108
  • Norm. En. per Res.: -3.7121
• Hub Node: A(6)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-43.9243	-25.1984	-422.335	-491.4577	179	33	9	21105	2	47	71
A-C	0.0	-4.6464	-41.0987	-45.7451	46	1	0	2286	0	20	20
A-D	0.0	-4.1116	-6.5256	-10.6373	14	0	1	620	0	4	7
A-E	-17.3098	-72.5456	-172.374	-262.2294	95	12	3	8060	8	46	42
A-F	0.0	-11.8506	-3.0797	-14.9303	31	0	0	492	0	16	20
A-H	0.0	-21.6546	-7.7612	-29.4159	27	0	0	772	1	9	16
B-C	0.0	-5.776	-15.8957	-21.6717	13	0	1	890	0	4	6
B-D	0.0	16.544	-61.7303	-45.1863	43	4	3	3310	0	18	17
B-F	0.0	0.0	-0.1975	-0.1975	10	0	0	67	0	5	6
B-G	-54.1947	-103.5599	-243.147	-400.9016	108	14	4	10840	8	76	57
B-H	-6.9567	-6.082	-98.9531	-111.9918	54	4	1	4394	3	35	40
C-D	-19.4017	-74.2286	-431.107	-524.7373	170	36	9	20967	5	45	64
C-E	0.0	1.2492	-12.5871	-11.3379	27	0	0	1033	1	11	14
C-G	-6.4135	-5.9307	-11.6928	-24.037	23	2	0	641	0	10	11
C-H	-26.0745	-21.638	-158.317	-206.0295	89	11	4	7680	2	40	40
D-E	-2.4048	-9.168	-71.2412	-82.814	50	6	2	3966	4	36	41
D-F	-35.3561	-100.1321	-224.496	-359.9842	103	4	4	10102	8	65	48
D-G	0.0	0.0	-0.2227	-0.2227	16	0	0	64	0	6	5
E-F	-45.9597	14.3614	-216.436	-248.0343	105	22	11	10594	0	34	34
G-H	-34.8764	20.2803	-198.328	-212.9241	99	9	11	9793	0	32	31

Interface residues

• A-B: ALA102A, ALA102B, ALA13A, ALA13B, ALA55A, ARG103A, ARG103B, ARG112A, ARG112B, ARG116A, ARG116B, ARG24A, ARG24B, ARG31A, ARG31B, ARG82A, ARG82B, ARG91A, ARG91B, ASN124A, ASN124B, ASN18A, ASN18B, ASN297A, ASN297B, ASN38A, ASN38B, ASP312A, ASP312B, GLN19A, GLN19B, GLN25A, GLN25B, GLN299B, GLN40A, GLN40B, GLN51A, GLN51B, GLN70A, GLN70B, GLN77A, GLN77B, GLN95A, GLN95B, GLU10A, GLU10B, GLU114A, GLU114B, GLU11A, GLU11B, GLU123A, GLU123B, GLU14A, GLU14B, GLU27A, GLU27B, GLU41A, GLU41B, GLU48A, GLU48B, GLU66A, GLU66B, GLU75A, GLU75B, GLY108A, GLY108B, GLY28A, GLY28B, GLY76A, GLY76B, HIS117A, HIS117B, HIS74A, HIS74B, ILE110A, ILE110B, ILE72A, ILE72B, ILE79A, ILE79B, ILE96A, ILE96B, LEU17A, LEU17B, LEU23A, LEU23B, LEU315A, LEU315B, LEU52A, LEU52B, LEU56A, LEU7A, LEU7B, LEU81A, LEU81B, LEU89A, LEU89B, LEU8A, LEU8B, LEU92A, LEU92B, LYS109A, LYS109B, LYS113A, LYS113B, LYS115A, LYS115B, LYS21A, LYS21B, LYS32A, LYS32B, LYS67A, LYS67B, LYS73A, LYS73B, MET15A, MET15B, MET311A, MET311B, MET43A, MET43B, PHE107A, PHE107B, PHE111A, PHE111B, PHE298A, PHE298B, PHE47A, PHE47B, PHE69A, PHE69B, PHE71A, PHE71B, PHE85A, PHE85B, PRO44A, PRO44B, PRO45A, PRO45B, PRO88A, PRO88B, PRO9A, PRO9B, SER105A, SER105B, SER12A, SER12B, SER35A, SER35B, SER46A, SER46B, SER78A, SER78B, SER94A, SER94B, THR122B, THR16A, THR16B, THR50A, THR50B, THR80A, THR80B, TYR104A, TYR104B, TYR106A, TYR106B, TYR125A, TYR125B, TYR39A, TYR39B, TYR49A, TYR49B, TYR6A, TYR6B, TYR93B, VAL20A, VAL20B, VAL42A, VAL42B
• A-C: ARG116A, ASN64A, ASN64C, GLN51A, GLN51C, GLN65A, GLN65C, GLN70A, GLN70C, GLN77A, GLN77C, GLU114A, GLU114C, GLU11A, GLU66A, GLU66C, GLU75A, GLU75C, GLY76A, GLY76C, HIS74C, ILE72A, ILE72C, ILE79A, LYS113A, LYS113C, LYS115A, LYS115C, LYS61A, LYS67A, LYS67C, LYS73A, LYS73C, MET68A, MET68C, PHE63A, PHE69A, PHE71A, PHE71C, SER78A, SER78C, THR50A, THR50C, THR54A, THR54C, THR62A
• A-D: ARG116A, ARG116D, GLN70A, GLU75A, GLU75D, GLY76A, GLY76D, HIS74A, HIS74D, ILE72A, ILE72D, LYS73A, LYS73D, PHE71A
• A-E: ALA197A, ALA276A, ALA280A, ALA281A, ARG116A, ARG119E, ARG180E, ARG223A, ARG320A, ASN184E, ASN196A, ASN219A, ASN282A, ASN76E, ASP191A, ASP193E, ASP259A, ASP64E, ASP74E, ASP77E, ASP79E, ASP80E, GLN283A, GLU162A, GLU185A, GLU200A, GLU200E, GLU203E, GLU214A, GLU220A, GLU59E, GLU83E, GLY194A, GLY261A, GLY61E, HIS117A, HIS60E, ILE182E, ILE195E, ILE196E, ILE215A, ILE217A, ILE257A, ILE258A, ILE285A, ILE62E, LEU186A, LEU187A, LEU188A, LEU192A, LEU195A, LEU260A, LEU58E, LEU73E, LEU84E, LEU85E, LEU87E, LYS115A, LYS158A, LYS185E, LYS189A, LYS189E, LYS190A, LYS191E, LYS192E, LYS213A, LYS254A, LYS275A, LYS3E, LYS70E, LYS88E, MET181E, MET262A, PHE161A, PHE188E, PHE190E, PHE216A, PHE78E, PRO284A, SER186E, SER187E, SER193A, SER278A, SER279A, THR159A, THR218A, THR56E, TYR277A, TYR81E, TYR82E, TYR86E, VAL160A, VAL183E, VAL199E, VAL263A
• A-F: ALA126F, ARG109F, ARG112F, ARG116A, ARG320A, ASN18A, ASP131F, GLN108F, GLN129F, GLN19A, GLU10A, GLU130F, GLU133F, GLU14A, GLU319A, GLU322A, HIS110F, HIS117A, ILE132F, ILE134F, ILE135F, LEU323A, LEU7A, LEU8A, LYS105F, LYS122F, LYS136F, LYS316A, PRO9A, THR16A, TYR6A
• A-H: ARG109H, ARG119H, ARG91A, ASN106H, ASN297A, ASP131H, ASP77H, ASP98A, GLN108H, GLN129H, GLN299A, GLN77A, GLN95A, GLU130H, GLU75A, HIS110H, ILE132H, ILE96A, LEU92A, LYS111H, LYS122H, LYS128H, LYS73A, LYS97A, PHE298A, SER94A, TYR49A
• B-C: GLN70C, GLN77C, GLU75B, GLU75C, GLY76B, GLY76C, HIS74B, HIS74C, ILE72B, ILE72C, LYS73B, LYS73C, PHE71C
• B-D: ASN64B, ASN64D, GLN51B, GLN51D, GLN65B, GLN65D, GLN70B, GLN70D, GLN77B, GLN77D, GLU66B, GLU66D, GLU75B, GLU75D, GLY76B, GLY76D, HIS74B, HIS74D, ILE72B, ILE72D, ILE79B, ILE79D, LYS113B, LYS113D, LYS115B, LYS115D, LYS67B, LYS67D, LYS73B, LYS73D, MET68B, MET68D, PHE69B, PHE69D, PHE71B, PHE71D, SER78B, SER78D, THR50B, THR50D, THR54B, THR54D, THR80D
• B-F: ASN106F, ASP131F, GLN129F, GLN95B, GLU130F, GLU75B, HIS110F, LYS122F, LYS128F, LYS97B
• B-G: ALA197B, ALA276B, ALA280B, ALA281B, ARG116B, ARG119G, ARG120B, ARG180G, ARG223B, ARG320B, ASN184G, ASN196B, ASN219B, ASN282B, ASN52G, ASN76G, ASP191B, ASP193G, ASP259B, ASP64G, ASP74G, ASP77G, ASP79G, ASP80G, GLN206G, GLN283B, GLU114B, GLU162B, GLU185B, GLU200G, GLU203G, GLU214B, GLU220B, GLU59G, GLU66B, GLU75G, GLU83G, GLY119B, GLY194B, GLY261B, GLY61G, HIS117B, HIS60G, ILE182G, ILE195G, ILE196G, ILE215B, ILE217B, ILE257B, ILE258B, ILE285B, ILE55G, ILE62G, LEU186B, LEU187B, LEU188B, LEU192B, LEU195B, LEU58G, LEU73G, LEU84G, LEU85G, LEU87G, LYS115B, LYS118B, LYS123G, LYS158B, LYS185G, LYS189B, LYS189G, LYS190B, LYS191G, LYS192G, LYS213B, LYS254B, LYS275B, LYS316B, LYS3G, LYS61B, LYS67B, LYS70G, LYS88G, MET181G, MET262B, PHE161B, PHE188G, PHE190G, PHE216B, PHE57G, PHE78G, PRO284B, SER186G, SER187G, SER193B, SER278B, SER279B, THR159B, THR218B, THR56G, TYR277B, TYR81G, TYR82G, TYR86G, VAL160B, VAL183G, VAL199G, VAL263B, VAL63G
• B-H: ALA126H, ALA13B, ARG109H, ARG112H, ARG116B, ARG119H, ARG120B, ARG320B, ASN18B, ASP131H, GLN108H, GLN127H, GLN129H, GLN19B, GLU10B, GLU11B, GLU130H, GLU133H, GLU14B, GLU319B, GLU75H, GLY119B, HIS110H, HIS117B, ILE132H, ILE134H, ILE135H, LEU137H, LEU149H, LEU17B, LEU323B, LEU7B, LEU8B, LYS105H, LYS111H, LYS118B, LYS122H, LYS123H, LYS128H, LYS136H, LYS316B, MET15B, PHE107H, PHE125H, PRO118H, PRO9B, SER115H, SER121B, SER12B, THR121H, THR16B, TYR117H, TYR124H, TYR6B
• C-D: ALA102C, ALA102D, ALA13C, ALA13D, ALA55D, ARG103C, ARG103D, ARG112C, ARG112D, ARG116D, ARG120D, ARG24C, ARG24D, ARG31C, ARG31D, ARG82C, ARG82D, ARG91C, ARG91D, ASN124C, ASN124D, ASN18C, ASN18D, ASN297C, ASN297D, ASN38D, GLN19C, GLN19D, GLN40C, GLN40D, GLN51C, GLN51D, GLN70C, GLN70D, GLN77C, GLN77D, GLN95C, GLN95D, GLU10C, GLU10D, GLU114C, GLU114D, GLU11C, GLU11D, GLU123D, GLU14C, GLU14D, GLU27C, GLU27D, GLU41C, GLU41D, GLU48C, GLU48D, GLU66C, GLU66D, GLU75C, GLU75D, GLY108C, GLY108D, GLY76C, GLY76D, HIS117D, HIS74C, HIS74D, ILE110C, ILE110D, ILE72C, ILE72D, ILE79C, ILE79D, ILE96C, ILE96D, LEU17C, LEU17D, LEU23C, LEU23D, LEU315C, LEU315D, LEU52C, LEU52D, LEU7C, LEU7D, LEU81C, LEU81D, LEU89C, LEU89D, LEU8C, LEU8D, LEU92C, LEU92D, LYS109C, LYS109D, LYS113C, LYS113D, LYS115C, LYS115D, LYS21C, LYS21D, LYS32C, LYS32D, LYS67C, LYS67D, LYS73C, LYS73D, MET15C, MET15D, MET311C, MET311D, MET43C, MET43D, PHE107C, PHE107D, PHE111C, PHE111D, PHE298C, PHE298D, PHE47C, PHE47D, PHE69C, PHE69D, PHE71C, PHE71D, PHE85C, PHE85D, PRO44C, PRO44D, PRO45C, PRO45D, PRO88C, PRO88D, PRO9C, PRO9D, SER105C, SER105D, SER121D, SER12C, SER12D, SER35C, SER35D, SER46C, SER46D, SER78C, SER78D, SER94C, SER94D, THR122D, THR16C, THR16D, THR50C, THR50D, THR54C, THR80C, THR80D, TYR104C, TYR104D, TYR106C, TYR106D, TYR125C, TYR125D, TYR39C, TYR39D, TYR49C, TYR49D, TYR53C, TYR6C, TYR6D, VAL20C, VAL20D, VAL42C, VAL42D
• C-E: ARG119E, ARG91C, ASN106E, ASN297C, ASP131E, ASP77E, ASP98C, GLN129E, GLN299C, GLN95C, GLU130E, GLU172E, GLU75C, HIS110E, ILE132E, ILE96C, LEU92C, LYS111E, LYS122E, LYS128E, LYS73C, LYS97C, PHE125E, PHE298C, SER94C, TYR49C, TYR93C
• C-G: ALA126G, ARG109G, ARG112G, ASN18C, ASP131G, GLN108G, GLN129G, GLN19C, GLU10C, GLU130G, GLU14C, GLU319C, HIS110G, ILE132G, LEU17C, LEU323C, LEU7C, LEU8C, LYS122G, MET15C, PHE125G, THR16C, TYR6C
• C-H: ALA197C, ALA276C, ALA280C, ALA281C, ARG180H, ARG223C, ARG320C, ASN184H, ASN196C, ASN219C, ASN282C, ASP191C, ASP259C, ASP64H, ASP74H, ASP77H, ASP79H, ASP80H, GLN283C, GLU162C, GLU185C, GLU200C, GLU200H, GLU203H, GLU214C, GLU220C, GLU59H, GLU83H, GLY194C, GLY261C, GLY61H, HIS60H, ILE182H, ILE195H, ILE196H, ILE215C, ILE217C, ILE257C, ILE258C, ILE285C, ILE62H, LEU186C, LEU187C, LEU188C, LEU192C, LEU195C, LEU58H, LEU73H, LEU84H, LEU85H, LEU87H, LYS115C, LYS158C, LYS185H, LYS189C, LYS189H, LYS190C, LYS191H, LYS192H, LYS213C, LYS254C, LYS275C, LYS3H, LYS70H, LYS88H, MET181H, MET262C, PHE161C, PHE188H, PHE190H, PHE216C, PHE78H, PRO284C, SER186H, SER187H, SER193C, SER278C, SER279C, THR159C, THR218C, TYR277C, TYR81H, TYR82H, TYR86H, VAL160C, VAL183H, VAL199H, VAL263C, VAL63H
• D-E: ALA126E, ALA13D, ARG109E, ARG112E, ARG116D, ARG119E, ARG120D, ARG320D, ASN106E, ASN18D, ASP131E, ASP77E, GLN108E, GLN127E, GLN129E, GLN19D, GLU10D, GLU11D, GLU130E, GLU133E, GLU14D, GLU319D, GLY119D, HIS110E, HIS117D, ILE132E, ILE134E, ILE135E, LEU149E, LEU17D, LEU323D, LEU7D, LEU8D, LYS105E, LYS118D, LYS122E, LYS123E, LYS128E, LYS136E, LYS316D, MET15D, PHE107E, PHE125E, PRO118E, PRO9D, SER12D, THR121E, THR16D, TYR124E, TYR6D
• D-F: ALA197D, ALA276D, ALA280D, ALA281D, ARG116D, ARG119F, ARG120D, ARG180F, ARG223D, ARG320D, ASN184F, ASN196D, ASN219D, ASN282D, ASN52F, ASN76F, ASP191D, ASP193F, ASP259D, ASP64F, ASP74F, ASP77F, ASP79F, ASP80F, GLN283D, GLU114D, GLU162D, GLU185D, GLU200D, GLU200F, GLU203F, GLU214D, GLU220D, GLU59F, GLU75F, GLU83F, GLY119D, GLY194D, GLY261D, GLY61F, HIS117D, HIS60F, ILE182F, ILE195F, ILE196F, ILE215D, ILE217D, ILE257D, ILE258D, ILE285D, ILE55F, ILE62F, LEU186D, LEU187D, LEU188D, LEU192D, LEU195D, LEU58F, LEU73F, LEU84F, LEU85F, LEU87F, LYS115D, LYS118D, LYS158D, LYS185F, LYS189D, LYS189F, LYS190D, LYS191F, LYS192F, LYS213D, LYS254D, LYS275D, LYS316D, LYS3F, LYS70F, LYS88F, MET181F, MET262D, PHE161D, PHE188F, PHE190F, PHE216D, PHE78F, PRO284D, SER186F, SER187F, SER193D, SER278D, SER279D, THR159D, THR218D, THR56F, TYR277D, TYR81F, TYR82F, TYR86F, VAL160D, VAL183F, VAL199F, VAL263D, VAL63F
• D-G: ASN106G, ASP131G, ASP98D, GLN108G, GLN129G, GLN95D, GLU130G, GLU75D, HIS110G, ILE96D, LEU92D, LYS122G, LYS128G, LYS73D, LYS97D, TYR49D
• E-F: ALA114E, ALA114F, ALA150E, ALA150F, ALA165E, ALA165F, ALA5E, ALA5F, ARG112E, ARG112F, ARG34E, ARG34F, ASN161E, ASN161F, ASN166E, ASN166F, ASN52E, ASN52F, ASN76E, ASN76F, ASP53E, ASP53F, GLN37E, GLN37F, GLN45E, GLN45F, GLU133E, GLU133F, GLU138E, GLU138F, GLU142E, GLU142F, GLU35E, GLU35F, GLU59E, GLU59F, GLY139E, GLY139F, GLY144E, GLY144F, GLY148E, GLY148F, GLY49E, GLY49F, GLY61E, GLY61F, HIS60E, HIS60F, ILE134E, ILE134F, ILE135E, ILE135F, ILE46E, ILE47E, ILE47F, ILE62E, ILE62F, LEU137E, LEU137F, LEU143E, LEU143F, LEU149E, LEU149F, LEU168F, LEU36E, LEU36F, LEU58E, LEU58F, LYS116E, LYS116F, LYS136E, LYS136F, LYS3E, LYS3F, LYS50E, LYS50F, LYS8E, LYS8F, PHE48E, PHE48F, PHE57E, PHE57F, PRO145E, PRO145F, PRO51E, PRO51F, SER115F, SER140E, SER140F, THR162E, THR162F, THR56E, THR56F, THR72E, THR72F, VAL141E, VAL141F, VAL146E, VAL146F, VAL147E, VAL147F, VAL54E, VAL54F, VAL63E, VAL63F
• G-H: ALA114G, ALA114H, ALA150G, ALA150H, ALA165H, ALA5G, ALA5H, ARG112G, ARG112H, ARG34G, ASN161H, ASN166G, ASN166H, ASN52G, ASN52H, ASN76G, ASN76H, ASP53G, ASP53H, GLN37G, GLN37H, GLN45G, GLN45H, GLU133G, GLU133H, GLU138G, GLU138H, GLU142G, GLU142H, GLU35G, GLU59G, GLU59H, GLY139G, GLY139H, GLY144G, GLY144H, GLY148G, GLY148H, GLY49G, GLY49H, GLY61G, GLY61H, HIS60G, HIS60H, ILE134G, ILE134H, ILE135G, ILE135H, ILE38G, ILE46G, ILE46H, ILE47G, ILE47H, ILE62G, ILE62H, LEU137G, LEU137H, LEU143G, LEU143H, LEU149G, LEU149H, LEU168H, LEU36G, LEU58G, LEU58H, LYS116G, LYS116H, LYS136G, LYS136H, LYS3G, LYS3H, LYS50G, LYS50H, LYS8G, LYS8H, PHE48G, PHE48H, PHE57G, PHE57H, PRO145H, PRO51G, PRO51H, SER140G, SER140H, THR159H, THR162H, THR56G, THR56H, TYR99G, VAL141G, VAL141H, VAL146G, VAL146H, VAL147G, VAL147H, VAL54G, VAL54H, VAL63G, VAL63H