1YY9

structure of the extracellular domain of the epidermal growth factor receptor in complex with the fab fragment of cetuximab/erbitux/imc- c225

• Total interactions analyzed: 3
• Total true interactions: 3
• Strongest Interaction:
  • Chains: A-D
  • Int. Res.: 63
  • Norm. En. per Res.: -3.4879
• Hub Node: A(2)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-C	-16.3127	-2.154	-103.236	-121.7027	44	4	0	3796	0	6	4
A-D	-38.1443	-26.5737	-155.021	-219.739	63	9	4	5864	3	7	6
C-D	-45.2136	-37.5328	-409.793	-492.5394	183	18	13	17029	1	19	17

Interface residues

• A-C: ARG470A, ASN32C, ASN442A, ASN444A, ASN449A, ASN469A, ASN473A, ASN91C, ASN92C, ASN93C, ASP1C, CYS475A, GLN27C, GLN89C, GLN90C, GLU472A, GLU53C, GLY30C, GLY441A, GLY471A, HIS34C, ILE29C, ILE2C, ILE438A, ILE466A, ILE467A, LEU445A, LYS443A, LYS463A, LYS465A, LYS474A, LYS49C, PRO95C, SER26C, SER28C, SER418A, SER440A, SER468A, THR31C, THR464A, THR96C, THR97C, TRP94C, TYR50C
• A-D: ALA385A, ALA415A, ALA98D, ARG353A, ASN31D, ASN442A, ASN469A, ASN56D, ASN60D, ASN73D, ASP103D, ASP58D, GLN384A, GLN408A, GLN411A, GLU105D, GLY410A, GLY441A, GLY54D, GLY55D, HIS35D, HIS409A, ILE383A, ILE438A, ILE439A, ILE466A, ILE467A, ILE51D, LEU325A, LEU348A, LEU382A, LEU414A, LEU419A, LEU99D, LYS443A, LYS465A, LYS71D, PHE352A, PHE380A, PHE412A, PRO349A, SER418A, SER440A, SER468A, SER53D, THR100D, THR30D, THR57D, THR61D, THR64D, TRP386A, TRP47D, TRP52D, TYR101D, TYR102D, TYR104D, TYR32D, TYR59D, VAL350A, VAL416A, VAL417A, VAL437A, VAL50D
• C-D: ALA100C, ALA107D, ALA130C, ALA131D, ALA142D, ALA143D, ALA174D, ALA96D, ALA98D, ARG142C, ARG38D, ARG45C, ARG97D, ASN137C, ASN138C, ASN32C, ASN41C, ASN60D, ASN91C, ASN92C, ASP103D, ASP122C, ASP150D, ASP167C, ASP170C, ASP1C, ASP58D, ASP85C, CYS134C, CYS146D, CYS88C, CYS95D, GLN111D, GLN124C, GLN160C, GLN166C, GLN177D, GLN38C, GLN39D, GLN6C, GLN6D, GLN89C, GLN90C, GLU105D, GLU123C, GLU161C, GLU165C, GLU46D, GLU53C, GLY101C, GLY110D, GLY112D, GLY145D, GLY157C, GLY168D, GLY180D, GLY42C, GLY42D, GLY44D, GLY49D, GLY99C, HIS170D, HIS34C, HIS35D, ILE117C, ILE33C, ILE48C, ILE55C, ILE58C, ILE92D, LEU125C, LEU130D, LEU135C, LEU136C, LEU144D, LEU147D, LEU175C, LEU176D, LEU179C, LEU181C, LEU181D, LEU184D, LEU45D, LEU46C, LEU47C, LEU48D, LEU99D, LYS135D, LYS149D, LYS169C, LYS207C, LYS220D, LYS43D, LYS49C, PHE106D, PHE116C, PHE118C, PHE128D, PHE139C, PHE172D, PHE209C, PHE63D, PHE98C, PRO119C, PRO120C, PRO129D, PRO132D, PRO173D, PRO41D, PRO44C, PRO62D, PRO95C, SER114C, SER121C, SER126D, SER127C, SER131C, SER133D, SER159C, SER162C, SER167D, SER168C, SER174C, SER176C, SER177C, SER178D, SER179D, SER183D, SER185D, SER186D, SER192D, SER208C, SER40D, SER43C, SER54C, SER56C, THR100D, THR129C, THR141D, THR164C, THR166D, THR171D, THR172C, THR178C, THR180C, THR189D, THR40C, THR61D, THR64D, THR96C, THR97C, TRP109D, TRP35C, TRP36D, TRP47D, TRP52D, TRP94C, TYR101D, TYR102D, TYR104D, TYR108D, TYR173C, TYR182D, TYR36C, TYR50C, TYR59D, TYR86C, TYR87C, TYR94D, VAL115C, VAL127D, VAL132C, VAL133C, VAL148D, VAL163C, VAL169D, VAL175D, VAL187D, VAL188D, VAL190D, VAL217D, VAL37D, VAL50D